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1

Paul, P. H. Applications of planar laser-induced fluorescence imaging diagnostics to reacting flows. Washington, D. C: American Institute of Aeronautics and Astronautics, 1990.

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2

Karsten, König, Tanke H. J, Schneckenburger Herbert, Society of Photo-optical Instrumentation Engineers., European Optical Society, European Laser Association, and Netherlands Medical Laser Association, eds. Laser microscopy: 7-8 July 2000, Amsterdam, Netherlands. Bellingham, Wash., USA: SPIE, 2000.

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3

Brandt, Roland, and Lidia Bakota. Laser scanning microscopy and quantitative image analysis of neuronal tissue. New York: Humana Press, 2014.

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4

R, Hicks Y., and United States. National Aeronautics and Space Administration., eds. Imaging fluorescent combustion species in gas turbine flame tubes: On complexities in real systems. [Washington, DC]: National Aeronautics and Space Administration, 1997.

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5

United States. National Aeronautics and Space Administration., ed. Quantitative PLIF imaging in high-pressure combustion: Final technical report for the period June 11, 1990 to September 20, 1996. Stanford, CA: High Temperature Gasdynamics Laboratory, Mechanical Engineering Department, Stanford University, 1997.

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6

Rinaldo, Cubeddu, Commission of the European Communities. Directorate-General for Science, Research, and Development., and Society of Photo-optical Instrumentation Engineers., eds. Proceedings of optical biopsy and fluorescence spectroscopy and imaging: 9-10 September 1994, Lille, France. Bellingham, Wash., USA: SPIE, 1994.

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7

R, Lakowicz Joseph, and Geddes Chris D, eds. Topics in fluorescence spectroscopy. New York: Plenum Press, 1991.

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8

Basché, T. Single-molecule optical detection, imaging and spectroscopy. Weinheim: VCH, 1997.

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9

1941-, Alfano Robert R., ed. Advances in optical biopsy and optical mammography. New York: New York Academy of Sciences, 1998.

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10

Alfano, Robert R., and Stavros G. Demos. Optical biopsy IX: 24-26 January 2011, San Francisco, California, United States. Bellingham, Wash: SPIE, 2011.

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11

1941-, Alfano Robert R., International Biomedical Optics Society, and Society of Photo-optical Instrumentation Engineers., eds. Proceedings of optical biopsy II: 25-26 January 1998, San Jose, California. Bellingham, Wash., USA: SPIE, 1998.

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12

H, Bearman Gregory, Cabib Dario, Levenson Richard M, Society of Photo-optical Instrumentation Engineers., and International Biomedical Optics Society, eds. Spectral imaging: Instrumentation, applications, and analysis : 25 January 2000, San Jose, California. Bellingham, Wash., USA: SPIE, 2000.

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13

M, Levenson Richard, Bearman Gregory H, Mahadevan-Jansen Anita 1967-, and Society of Photo-optical Instrumentation Engineers., eds. Spectral imaging: Instrumentation, applications, and analysis II : 26 January 2003, San Jose, California, USA. Bellingham, Wash., USA: SPIE, 2000.

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14

Popp, Jürgen, Katarina Svanberg, and Irene Georgakoudi. Clinical and biomedical spectroscopy: 16-18 June 2009, Munich, Germany. Edited by United States. Air Force. Office of Scientific Research. Bellingham, Wash: SPIE, 2009.

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15

E, Cohn Gerald, Society of Photo-optical Instrumentation Engineers., and International Biomedical Optics Society, eds. Proceedings of systems and technologies for clinical diagnostics and drug discovery: 26-27 January 1998, San Jose, California. Bellingham, Wash: SPIE, 1998.

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16

1941-, Alfano Robert R., and Society of Photo-optical Instrumentation Engineers., eds. Optical biopsy IV: 21-23 January 2002, San Jose, USA. Bellingham, Wash., USA: SPIE, 2002.

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17

1941-, Alfano Robert R., International Biomedical Optics Society, and Society of Photo-optical Instrumentation Engineers., eds. Optical biopsy III: 23-24 January 2000, San Jose, California. Bellingham, Wash., USA: SPIE, 2000.

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18

Brandt, Roland, and Lidia Bakota. Laser Scanning Microscopy and Quantitative Image Analysis of Neuronal Tissue. Humana Press, 2016.

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19

Lacowicz, Joseph R. Protein Fluorescence. Springer, 2013.

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20

Lacowicz, Joseph R. Protein Fluorescence. Springer London, Limited, 2006.

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21

Lakowicz, Joseph R. Topics in Fluorescence Spectroscopy: Volume 5: Nonlinear and Two-Photon Induced Fluorescence (Topics in Fluorescence Spectroscopy). Springer, 1997.

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22

Lakowicz, Joseph R. Topics in Fluorescence Spectroscopy: DNA Technology (Topics in Fluorescence Spectroscopy). Springer, 2003.

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23

Lakowicz, Joseph R. Topics in Fluorescence Spectroscopy: Volume 2: Principles (Topics in Fluorescence Spectroscopy). Springer, 1992.

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24

(Editor), Chris D. Geddes, and Joseph R. Lakowicz (Editor), eds. Advanced Concepts in Fluorescence Sensing: Part B: Macromolecular Sensing (Topics in Fluorescence Spectroscopy). Springer, 2005.

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25

(Editor), Chris D. Geddes, and Joseph R. Lakowicz (Editor), eds. Advanced Concepts in Fluorescence Sensing: Part A: Small Molecule Sensing (Topics in Fluorescence Spectroscopy). Springer, 2005.

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26

Lakowicz, Joseph R. Topics in Fluorescence Spectroscopy: Volume 4: Probe Design and Chemical Sensing (Topics in Fluorescence Spectroscopy). Springer, 1994.

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27

(Editor), Chris D. Geddes, and Joseph Lakowicz (Editor), eds. Radiative Decay Engineering (Topics in Fluorescence Spectroscopy). Springer, 2005.

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28

Alfano, Robert, and Stavros Demos. Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis. SPIE, 2016.

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29

Alfano, Robert, and Alvin Katz. Optical Biopsy VI: 24 January 2006, San Jose, California, USA. SPIE, 2008.

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30

Kipnis, Eric, and Benoit Vallet. Tissue perfusion monitoring in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0138.

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Abstract:
Resuscitation endpoints have shifted away from restoring normal values of routinely assessed haemodynamic parameters (central venous pressure, mean arterial pressure, cardiac output) towards optimizing parameters that reflect adequate tissue perfusion. Tissue perfusion-based endpoints have changed outcomes, particularly in sepsis. Tissue perfusion can be explored by monitoring the end result of perfusion, namely tissue oxygenation, metabolic markers, and tissue blood flow. Tissue oxygenation can be directly monitored locally through invasive electrodes or non-invasively using light absorbance (pulse oximetry (SpO2) or tissue (StO2)). Global oxygenation may be monitored in blood, either intermittently through blood gas analysis, or continuously with specialized catheters. Central venous saturation (ScvO2) indirectly assesses tissue oxygenation as the net balance between global O2 delivery and uptake, decreasing when delivery does not meet demand. Lactate, a by-product of anaerobic glycolysis, increases when oxygenation is inadequate, and can be measured either globally in blood, or locally in tissues by microdialysis. Likewise, CO2 (a by-product of cellular respiration) and PCO2 can be measured globally in blood or locally in accessible mucosal tissues (sublingual, gastric) by capnography or tonometry. Increasing PCO2 gradients, either tissue-to-arterial or venous-to-arterial, are due to inadequate perfusion. Metabolically, the oxidoreductive status of mitochondria can be assessed locally through NADH fluorescence, which increases in situations of inadequate oxygenation/perfusion. Finally, local tissue blood flow may be measured by laser-Doppler or visualized through intravital microscopic imaging. These perfusion/oxygenation resuscitation endpoints are increasingly used and studied in critical care.
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31

Deckert, Volker, and Nirmala Ramanujam. Clinical and Biomedical Spectroscopy and Imaging III. SPIE, 2013.

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32

Cohn, Gerald E. Systems and Technologies for Clinical Diagnostics and Drug Discovery (Systems & Technologies for Clinical Diagnostics & Drug Disco). SPIE-International Society for Optical Engine, 1998.

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33

Optical biopsy V: 27-28 January 2004, San Jose, USA. Bellingham, Wash: SPIE, 2004.

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34

Optical biopsy V: 27-28 January 2004, San Jose, California, USA. Bellingham, WA: SPIE, 2004.

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35

Functional Imaging by Controlled Nonlinear Optical Phenomena Wiley Series in Biomedical Engineering and MultiDisciplinar. John Wiley & Sons, 2012.

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