Journal articles on the topic 'Laser development programme'

This paper describes the current and planned optical observations initiatives at ESA’s SSA Programme. Several coordinated observation campaigns comprising some sensors have been performed. First qualification results from one of these sensors, SHOT telescope from Teplice Observatory are presented. The concept of an Expert Centre facilitating the SSA space surveillance and tracking (SST) segment’s use of optical passive and laser ranging data from external sensors is detailed that is found relevant for the community of optical observers in SST. ESA’s two half-metre class telescopes on robotic mounts have been integrated in the frame of a technology development programme. Following an in-factory qualification programme, under human supervision and involving commercial, off-the-shelf processing software, for full-end autonomy and robustness testing, the deployment to final sites, covering both hemispheres, is expected to finalise in 2018. Main figure of merits of these robotic telescopes are described.

Two identical 1.9 litre direct injection (DI) diesel engines having optical access for application of laser diagnostics were operated at Volkswagen and Imperial College as part of the European programme (IDEA) on diesel engines. A variety of complementary laser-based techniques were used to characterize the flow-generating capacity of the intake system under steady flow conditions, the in-cylinder flow during induction and compression as well as the spray development, auto-ignition and combustion under three typical engine operating conditions. The most important results of this programme are presented and discussed here in view of their implications for improved combustion and reduction of exhaust emissions in small direct injection diesel engines, through better matching of the spray characteristics with the in-cylinder flow as a function of engine speed and load. The results were obtained in sufficient detail to allow validation of the multi-dimensional computer code developed within the IDEA programme.

This article describes the current status of the KrF development programme based on the Sprite laser system at the Rutherford Appleton Laboratory. High reliability and high shot rate have been demonstrated. Using a unique KrF-pumped Raman laser architecture, beam brightness exceeding 2×1019 Wcm-2 sterad-1 giving a focussed intensity >5 ×1017 Wcm-2 has been achieved. The development of transform-limited short-pulse oscillators is shown to be of importance in avoiding spectral broadening in air propagation of high-intensity beams. Beam smoothing of KrF beams in a multiplexed configuration has been demonstrated for the first time. The technique of echelon-free induced spatial incoherence has been shown to produce smooth intensity distributions in the far field, which remain essentially unchanged on amplification. The development of pulsed-power systems capable of exciting multikilojoule laser amplifiers for the next phase of development, the Supersprite system, is briefly discussed.

Recent development of non-invasive and remote sensing modalities such as the Laser Doppler Perfusion Imager (LDPI) technology for probing the skin blood perfusion and its spatial variability over a region of interest, allows for detailed analysis of alterations in skin blood perfusion, with virtually no disturbance of the microcirculation under study. In this study, we have investigated perfusion flux pattern changes obtained from the abdominal area of 30 Chinese male patients (mean age of 26, presented only 2 typical cases) undergoing an acupuncture slimming course. The objective was to study the alterations in skin blood flux by detailed analysis of the Doppler images taken before, during which and after the insertion of needles. We explained the correlation of alterations of skin blood flux with the flow of Qi and the losses of body weight and body fat content. The purpose was to quantify a relationship between changes in perfusion flux pattern and the efficacy of weight loss through acupuncture. In conclusion, this study affirmed that skin blood perfusion flux values in the abdominal area were the highest, whilst the acupuncture needles were inserted. There is also evidence that the increased flux values occurred along the meridian channels of acupuncture, thereby acknowledging the flow of Qi in them. Hence, further clinical studies in the use of LDPI to investigate acupuncture with more subjects are warranted.

Charting Terra Incognita is a project grant that brings together the IPN Orsay, CSNSM Orsay and Irfu-SPHN laboratories around the common development of knowhow, equipment and techniques for mass spectrometry and nuclear spectroscopy at the low-energy branch of the new S3 spectrometer at Ganil, where likewise the Reglis set-up for intrajet laser spectroscopy is entering its final phase of construction. At the same time its concerted action initiates and sets the pace for the corresponding precursor physics programme at the Alto on-line isotope-separation facility, based on the photofission of uranium. We also collect a review of the Alto laser ion source, which is an essential instrument at any low-energy facility for the production of purified isotopic beams.

A detailed and comprehensive programme is undertaken in India to fabricate Indian Test Blanket Module (TBM) to be tested in ITER. Development of India-specific Reduced Activation Ferritic/Martensitic (RAFM) steel has been realized through melting and physical and mechanical properties characterization of several heats of 9Cr-RAFM steel with varying tungsten and tantalum contents. The RAFM steel having 1.4 wt. % tungsten and 0.06 wt. % tantalum is found to possess better combination of strength and toughness and is considered as India-specific RAFM steel. Different joining processes for fabrication of TBM have been assessed. Hot Isostatic Pressing (HIP) has been demonstrated to fabricate the first wall of TBM. To avoid channel collapse during HIPing, leachable ceramic cores were inserted in the channels. Electron Beam (EB) and Laser Welding processes are used for fabrication of breeder cassettes and hence, these welding procedures have been developed. Tungsten Inert Gas (TIG), Narrow Gap TIG (NG-TIG) and Laser Hybrid welding processes are being considered for integration of the various components such as first wall, back plate, bottom plate, breeder assembly and flow dividers into TBM. RAFM steel welding consumables have also been developed and qualified. Procedure for laser hybrid welding has also been developed. Necessary technologies for inspection and quality assurance of the fabricated TBM are also being developed. Use of ultrasonic C-Scan imaging to examine the bond integrity of the HIP joint has been demonstrated. Phased Array technique that would enable inspection of welds by longitudinal movement of the probe from an optimised lateral distance of the weld without the requirement of lateral movement has also been developed. The challenges in developing the India-specific RAFM steel and the fabrication and inspection technologies for fabrication of Indian TBM are presented.

Abstract The article describes chosen, yet key parts of newly established European, infrastructural research and development project ARIES (2017-2020) - Accelerator Research and Innovation for European Science and Society, to be realized inside the framework of the H2020 programme. Two institutions from Poland participate in ARIES – these are Warsaw University of Technology and Institute of Nuclear Chemistry and Technology. ARIES is a topical continuation of the previous infrastructural accelerator projects realized uninterruptedly since 2003 – FP6 CARE – Coordinated Accelerator Research in Europe and FP7 TIARA – Test Infrastructure and Accelerator Research Area, EuCARD – European Coordination for Accelerator Research and Development, and EuCARD2. The article is simultaneously a part of a series of papers concerning the participation of Polish doctoral students and young researchers, especially from the Warsaw University of Technology, in large European and world experiments of the discovery class, including building large research infrastructures like: FLASH and EXFEL, ESS, ITER and DEMO, IFMIF, but also satellites built by the ESA, etc. ARIES embraces, among others, the following subjects: energy efficiency and management, cost lowering, miniaturization and ultra-high field gradients, promotion innovation, industrial applications, societal implications, new materials and components, new methods of particles acceleration including laser-plasma-particles interaction, and building new generations of systems.

SummaryAutophagy is a major intracellular pathway for the degradation and recycling of cytosolic components. Emerging evidence has demonstrated its crucial role during the embryo development of invertebrates and vertebrates. We recently demonstrated a massive activation of autophagy in Paracentrotus lividus embryos under cadmium stress conditions, and the existence of a temporal relationship between induced autophagy and apoptosis. Although there have been numerous studies on the role of autophagy in the development of different organisms, information on the autophagic process during oogenesis or at the start of development in marine invertebrates is very limited. Here we report our recent data on the occurrence of autophagy at these key phases of development. In order to investigate autophagy trends we performed in vivo assays to detect autophagolysomes, as well as in situ analysis with anti-LC3 antibody to detect autophagosomes before the fusion with lysosomes. From data generated through confocal laser scanning microscopy and quantification of autophagic signals we have drawn several unequivocal conclusions. The results showed a copious and rising number of autophagic organelles that had specific localization. Interestingly the increase in autophagy that occurred just after fertilization has been proved to be crucial for correct initiation of the developmental programme: irreversible developmental delays and morphologic anomalies were induced by short autophagic inhibition. This work focused on the sea urchin model system and corroborates evidence on the need for self-digestion during development, enriching the knowledge on autophagy, a biological mechanism belonging to evolutionarily different organisms.

BackgroundThe English NHS Diabetic Eye Screening Programme was established in 2003. Eligible people are invited annually for digital retinal photography screening. Those found to have potentially sight-threatening diabetic retinopathy (STDR) are referred to surveillance clinics or to Hospital Eye Services.ObjectivesTo determine whether personalised screening intervals are cost-effective.DesignRisk factors were identified in Gloucestershire, UK using survival modelling. A probabilistic decision hidden (unobserved) Markov model with a misgrading matrix was developed. This informed estimation of lifetime costs and quality-adjusted life-years (QALYs) in patients without STDR. Two personalised risk stratification models were employed: two screening episodes (SEs) (low, medium or high risk) or one SE with clinical information (low, medium–low, medium–high or high risk). The risk factor models were validated in other populations.SettingGloucestershire, Nottinghamshire, South London and East Anglia (all UK).ParticipantsPeople with diabetes in Gloucestershire with risk stratification model validation using data from Nottinghamshire, South London and East Anglia.Main outcome measuresPersonalised risk-based algorithm for screening interval; cost-effectiveness of different screening intervals.ResultsData were obtained in Gloucestershire from 12,790 people with diabetes with known risk factors to derive the risk estimation models, from 15,877 people to inform the uptake of screening and from 17,043 people to inform the health-care resource-usage costs. Two stratification models were developed: one using only results from previous screening events and one using previous screening and some commonly available GP data. Both models were capable of differentiating groups at low and high risk of development of STDR. The rate of progression to STDR was 5 per 1000 person-years (PYs) in the lowest decile of risk and 75 per 1000 PYs in the highest decile. In the absence of personalised risk stratification, the most cost-effective screening interval was to screen all patients every 3 years, with a 46% probability of this being cost-effective at a £30,000 per QALY threshold. Using either risk stratification models, screening patients at low risk every 5 years was the most cost-effective option, with a probability of 99-100% at a £30,000 per QALY threshold. For the medium-risk groups screening every 3 years had a probability of 43 –48% while screening high-risk groups every 2 years was cost-effective with a probability of 55–59%.ConclusionsThe study found that annual screening of all patients for STDR was not cost-effective. Screening this entire cohort every 3 years was most likely to be cost-effective. When personalised intervals are applied, screening those in our low-risk groups every 5 years was found to be cost-effective. Screening high-risk groups every 2 years further improved the cost-effectiveness of the programme. There was considerable uncertainty in the estimated incremental costs and in the incremental QALYs, particularly with regard to implications of an increasing proportion of maculopathy cases receiving intravitreal injection rather than laser treatment. Future work should focus on improving the understanding of risk, validating in further populations and investigating quality issues in imaging and assessment including the potential for automated image grading.Study registrationIntegrated Research Application System project number 118959.Funding detailsThe National Institute for Health Research Health Technology Assessment programme.

Derek Robinson was a leading UK plasma physicist of his generation. After an early success in measuring the electron temperature in the ZETA plasma through the Thomson scattering of laser light, he became a key member of the team from Culham Laboratory sent to Moscow in 1968 to verify the high temperatures claimed by the Russians for their T3 tokamak. On returning to Culham his research activities continued to broaden and he became an acknowledged expert on a range of fusion devices. His management responsibilities grew in parallel and eventually he became Director of Culham. With his strong support, Culham explored the novel spherical tokamak devices START and MAST, and he promoted this concept as an alternative route to the conventional tokamak for developing fusion power. His energetic leadership and his mastery of theory, experiment and fusion politics brought fusion power nearer to reality. His vision of the ‘way forward’ for the international fusion programme remains with us after his life was so sadly cut short by the unexpected development of lung cancer in a non-smoker.

AbstractProject MERIT was an international programme to Monitor Earth Rotation and Intercompare the Techniques of observation and analysis. It was conceived by a working group that was set up by the International Astronomical Union in 1978 and was carried through with additional support from the International Union of Geodesy and Geophysics. The first objective was to encourage the development of the use of new techniques, such as laser ranging and radio interferometry, for the regular determination of universal time and polar motion. A successful ‘short campaign’ of observations by six techniques was carried out during the period 1980 August to October. Operational and analysis centres were set up for each technique and a coordinating centre was established at the Bureau International de l’Heure (BIH). The results were reported and discussed at the first MERIT Workshop in 1981.The preparations for the ‘main campaign’, which was held from 1983 September 1 to 1984 October 31, and the plans for the activities that were to follow it were reviewed at the second MERIT Workshop in 1983. Important additional features of the campaign included the use of ‘MERIT Standards’ for the reduction and analysis of the data, the use of electronic techniques for the distribution of data, the comparison of the results with the changes in the angular momentum of the atmosphere and special emphasis on the improvement of the terrestrial reference frame. Proposals for a new International Earth Rotation Service were prepared at the third MERIT Workshop in 1986. The MERIT programme was continued from 1984 until the new service formally started on 1988 January 1. Over the decade the accuracy of the Earth-rotation parameters improved considerably.

Abstract The aim of the study was to determine the morphological characteristics of selected spring-heads in the Knyszyńska Primeval Forest and to identify lithological conditions in areas where groundwater flows to the surface. During the study, detailed bed level measurements of the spring-head areas were conducted. Lidar laser data obtained from the Central Department of Geodetic and Cartographic Documentation in Warsaw were also used for the analysis of morphometry. Based on the data, the detailed contour maps were created in the Surfer 12 programme and the basic parameters of the morphometry of the studied springs were determined. To detect lithological conditions, granulometric analyses were conducted and the filtration coefficient of aquifers in the individual spring-heads was calculated using Hazen and USBSC empirical models. Due to the morphological situation, the examined objects were classified as sub-slope and riverbank spring-heads. In terms of shape, spring-head alcoves are classified as basin-shaped, bowl-shaped and spindle-shaped alcoves. Different morphological processes prevail in each of these types. Basin-shaped alcoves are formed mainly by lateral erosion, bowlshaped alcoves by seepage erosion, landsliding and accumulation in the bottom, spindle-shaped alcoves by seepage erosion, headward erosion, breaking and collapsing. In the investigated outflows of groundwater aquifers are sands and glacifluvial sands with gravel of varying grain size. The lithological variation of aquifers in the spring-heads, directly affects the rate of groundwater filtration in different parts of the alcoves, which in turn leads to different morphogenetic processes and results in changes in the morphology of the spring-head alcoves.

Abstract. The old town of Gjirokastra (Albania), was included in the World Heritage List in 2005 thanks to the valuable presence of several remarkable examples of Ottoman-styled houses and in the integrity of the vernacular urban landscape. The urban structure is strongly influenced by the orography of the Drino valley and its slopes where the city was founded. Stone is the building material that characterizes the paving of the streets, the walls of the buildings and the roof coverings. The wood, mostly local, was used to build the frame structure of the upper floors and the roofs, in order to provide large windows and bright interior spaces. In December 2018, as part of the activities of the 3D Past project, founded by Eu Creative Europe Programme, Italian and Albanian students took part in a workshop in Gjirokastra. Such an initiative was designed to understand the tangible and intangible components of the vernacular heritage of Gjrokastra. In a multidisciplinary approach, students, professors, researchers and local experts analysed the morphological features of the historic center, the public spaces, and the traditional building systems. Traditional instruments such as the direct survey, the on-site observation and the interviews were adopted in combination with more innovative tools such as the laser scanner and the photogrammetry. This contribution not only illustrates the results of a multi-scale analysis, but it also highlights the transformations and threats that endanger the transmission of the unique characteristics of the city to the future generations. Moreover, it deals with the conservation strategies currently in use and some possible future measures that can contribute to the sustainable safeguard and development of the site.

The management of an urban context in a Smart City perspective requires the development of innovative projects, with new applications in multidisciplinary research areas. They can be related to many aspects of city life and urban management: fuel consumption monitoring, energy efficiency issues, environment, social organization, traffic, urban transformations, etc. Geomatics, the modern discipline of gathering, storing, processing, and delivering digital spatially referenced information, can play a fundamental role in many of these areas, providing new efficient and productive methods for a precise mapping of different phenomena by traditional cartographic representation or by new methods of data visualization and manipulation (e.g. three-dimensional modelling, data fusion, etc.). The technologies involved are based on airborne or satellite remote sensing (in visible, near infrared, thermal bands), laser scanning, digital photogrammetry, satellite positioning and, first of all, appropriate sensor integration (online or offline). The aim of this work is to present and analyse some new opportunities offered by Geomatics technologies for a Smart City management, with a specific interest towards the energy sector related to buildings. Reducing consumption and CO2 emissions is a primary objective to be pursued for a sustainable development and, in this direction, an accurate knowledge of energy consumptions and waste for heating of single houses, blocks or districts is needed. A synoptic information regarding a city or a portion of a city can be acquired through sensors on board of airplanes or satellite platforms, operating in the thermal band. A problem to be investigated at the scale A problem to be investigated at the scale of the whole urban context is the Urban Heat Island (UHI), a phenomenon known and studied in the last decades. UHI is related not only to sensible heat released by anthropic activities, but also to land use variations and evapotranspiration reduction. The availability of thermal satellite sensors is fundamental to carry out multi-temporal studies in order to evaluate the dynamic behaviour of the UHI for a city. Working with a greater detail, districts or single buildings can be analysed by specifically designed airborne surveys. The activity has been recently carried out in the EnergyCity project, developed in the framework of the Central Europe programme established by UE. As demonstrated by the project, such data can be successfully integrated in a GIS storing all relevant data about buildings and energy supply, in order to create a powerful geospatial database for a Decision Support System assisting to reduce energy losses and CO2 emissions. Today, aerial thermal mapping could be furthermore integrated by terrestrial 3D surveys realized with Mobile Mapping Systems through multisensor platforms comprising thermal camera/s, laser scanning, GPS, inertial systems, etc. In this way the product can be a true 3D thermal model with good geometric properties, enlarging the possibilities in respect to conventional qualitative 2D images with simple colour palettes. Finally, some applications in the energy sector could benefit from the availability of a true 3D City Model, where the buildings are carefully described through three-dimensional elements. The processing of airborne LiDAR datasets for automated and semi-automated extraction of 3D buildings can provide such new generation of 3D city models.

A number of authors have described the zoeal development of the Chinese mitten crab, Eriocheir sinensis H. Milne Edwards, 1853, while some of these studies only recognised 5 zoeal stages, two of them described six. The present study re-examined the zoeal stages of E. sinensis from laboratory-reared material using confocal laser scanning microscopy and visualised the images using the open-source software programmes ImageJ and Drishti. From these images 6 zoeal stages were re-described and compared with all previous larval descriptions of the Chinese mitten crab. Comments on the variation of some setal characters are also described in zoeal stages IV−VI.

The general trend of microscopical investigation in biology from the 1950s to the early 1970s was towards obtaining structural information. This goal initially was met using heavy metal and/or aldehyde fixatives, room temperature dehydration with polar organic liquids, embedding with epoxy and acrylate resins, and thin sectioning at room temperature. By the mid 1970s, a perceptible change occurred in the direction of both light and analytical electron microscopy towards investigation of the chemical reactivity and composition of structures made visible with increasingly better spatial resolution for light and electron microscopes. During the past 25 years there have been considerable innovations in microanalytical techniques, including analytical electron and x-ray microscopy and microanalysis, secondary ion mass spectrometry, laser microprobe mass analysis, the scanning probe microscopies, and confocal/multi-photon microscopy. In addition, cryopreservation and the development of chromophores for visualization of molecular and ionic sites within individual living cells as well as membranes have redefined the goal of microscopical preservation: to stabilize cell structure and composition as they exist in the living state.

The European X-ray free-electron laser (XFEL) facility, under construction in the Hamburg region, will provide high-peak brilliance (greater than 10 33 photons s −1 mm −2 mrad −2 per 0.1% BW), ultrashort pulses (approx. 10 fs) of X-rays, with a high repetition rate (up to 27 000 pulses s −1 ) from 2016 onwards. The main features of this exceptional X-ray source, and the instrumentation developments necessary to exploit them fully, for application to a variety of scientific disciplines, are briefly summarized. In the case of structural biology, that has a central role in the scientific case of this new facility, the instruments and ancillary laboratories that are being planned and built within the baseline programme of the European XFEL and by consortia of users are also discussed. It is expected that the unique features of the source and the advanced features of the instrumentation will allow operation modes with more efficient use of sample materials, faster acquisition times, and conditions better approaching feasibility of single molecule imaging.

Aponogeton madagascariensis (Mirb.) H. Bruggen is an aquatic monocot that develops perforations in its leaves through developmentally regulated programmed cell death (PCD). Aponogeton boivinianus Baill. ex Jum. is a close relative found in comparable environments with leaves that have a similar shape with no perforations. Little is known about the early developmental morphology of the family. This study characterized and compared these two species via scanning electron microscopy (SEM) and confocal laser scanning microscopy using both fresh and fixed specimens. The shoot apical meristem (SAM) of A. madagascariensis was significantly larger than that of A. boivinianus, but there was no difference in phyllotaxy observed, as both exhibited a 2/5 spiral pattern. A novel technique using serial dissections and SEM of fresh, hydrated specimens revealed that there are 16 plastochrons before perforation formation in A. madagascariensis and 34 plastochrons until a similar developmental stage in A. boivinianus. The effects on early development of A. madagascariensis plants with supressed ethylene production were also analyzed. Ethylene inhibition alters leaf development by blocking PCD, but had no significant effect on the SAM morphology or early leaf development in A. madagascariensis.

Perforation formation in Aponogeton madagascariensis (Mirb.) H.Bruggen (lace plant) is an excellent model for studying developmentally regulated programmed cell death (PCD). In this study, we isolated and identified two lace plant vacuolar processing enzymes (VPEs) and investigated their involvement in PCD and throughout leaf development. Lace plant VPE transcript levels were determined during seven different stages of leaf development. PCD and non-PCD cells from “window” stage leaves (in which perforations are forming) were separated through laser-capture microscopy and their transcript levels were also determined. VPE activity was also studied between the cell types, through a VPE activity-based probe JOPD1. Additionally, VPE transcript levels were studied in plants treated with an ethylene biosynthesis inhibitor, aminoethoxyvinylglycine (AVG). The two isolated VPEs, AmVPE1 and AmVPE2, are vegetative type VPEs. AmVPE1 had higher transcript levels during a pre-perforation developmental stage, immediately prior to visible signs of PCD. AmVPE2 transcript levels were higher later during window and late window stages. Both VPEs had higher transcript and activity levels in PCD compared with the non-PCD cells. AVG treatment inhibited PCD and associated increases in VPE transcript levels. Our results suggested that VPEs are involved in the execution of the ethylene-related PCD in the lace plant.

Fast technological developments in photogrammetry and remote sensing areas demand quick and steady changes in the education programme and its realization. The university teachers and assistants are faced with ensuring the learning materials, data and software for practical lessons, as well as project proposals for student’s team work and bachelor or master thesis. In this paper the emerging topics that already have a considerable impact in the practice are treated mostly from the educational aspect. These relatively new topics that are considered in this paper are unmanned aerial systems for spatial data collection, terrestrial and aerial laser scanning, mobile mapping systems, and novelties in satellite remote sensing. The focus is given to practical implementation of these topics into the teaching and learning programme of Geodesy and Geoinformation at the University of Ljubljana, Faculty of Civil and Geodetic Engineering, and experiences gained by the authors so far. Together with the technological advances, the teaching approaches must be modernized as well. Classical approaches of teaching, where a lecturer gives lecture <i>ex cathedra</i> and students are only listeners, are not effective enough. The didactics science of teaching has developed and proved in the practice many useful approaches that can better motivate students for more active learning. We can use different methods of team work like pro et contra debate, buzzing groups, press conference, moderated discussion etc. An experimental study on active teaching methods in the class of students of the Master programme of Geodesy and Geoinformation has been made and the results are presented. After using some new teaching methods in the class, the students were asked to answer two types of a questionnaire. First questionnaire was the standard form developed by Noel Entwistle, an educational psychologist who developed the Approaches to Studying Inventory (ASI) for identifying deep and surface approaches to learning. The second questionnaire was developed for our purpose to get the feedback from students on active teaching and learning methods. Although this investigation has been done only for one class of master programme students, the results are encouraging and we could extract some recommendations for the future.

Fast technological developments in photogrammetry and remote sensing areas demand quick and steady changes in the education programme and its realization. The university teachers and assistants are faced with ensuring the learning materials, data and software for practical lessons, as well as project proposals for student’s team work and bachelor or master thesis. In this paper the emerging topics that already have a considerable impact in the practice are treated mostly from the educational aspect. These relatively new topics that are considered in this paper are unmanned aerial systems for spatial data collection, terrestrial and aerial laser scanning, mobile mapping systems, and novelties in satellite remote sensing. The focus is given to practical implementation of these topics into the teaching and learning programme of Geodesy and Geoinformation at the University of Ljubljana, Faculty of Civil and Geodetic Engineering, and experiences gained by the authors so far. Together with the technological advances, the teaching approaches must be modernized as well. Classical approaches of teaching, where a lecturer gives lecture <i>ex cathedra</i> and students are only listeners, are not effective enough. The didactics science of teaching has developed and proved in the practice many useful approaches that can better motivate students for more active learning. We can use different methods of team work like pro et contra debate, buzzing groups, press conference, moderated discussion etc. An experimental study on active teaching methods in the class of students of the Master programme of Geodesy and Geoinformation has been made and the results are presented. After using some new teaching methods in the class, the students were asked to answer two types of a questionnaire. First questionnaire was the standard form developed by Noel Entwistle, an educational psychologist who developed the Approaches to Studying Inventory (ASI) for identifying deep and surface approaches to learning. The second questionnaire was developed for our purpose to get the feedback from students on active teaching and learning methods. Although this investigation has been done only for one class of master programme students, the results are encouraging and we could extract some recommendations for the future.

Fusion of bilateral shelves, to form the definitive mammalian secondary palate, is critically dependent on removal of the medial edge cells that constitute the midline epithelial seam. Conflicting views suggest that programmed apoptotic death or epithelial-mesenchymal transformation of these cells is predominantly involved. Due in part to the potentially ambiguous interpretation of static images and the notable absence of fate mapping studies, the process by which this is achieved has, however, remained mechanistically equivocal. Using an in vitro mouse model, we have selectively labelled palatal epithelia with DiI and examined the fate of medial edge epithelial (MEE) cells during palatal fusion by localisation using a combination of conventional histology and confocal laser scanning microscopy (CLSM). In dynamic studies using CLSM, we have made repetitive observations of the same palatal cultures in time-course investigations. Our results concurred with the established morphological criteria of seam degeneration; however, they provided no evidence of MEE cell death or transformation. Instead we report that MEE cells migrate nasally and orally out of the seam and are recruited into, and constitute, epithelial triangles on both the oral and nasal aspects of the palate. Subsequently these cells become incorporated into the oral and nasal epithelia on the surface of the palate. We hypothesize an alternative method of seam degeneration in vivo which largely conserves the MEE population by recruiting it into the nasal and oral epithelia.

Intergeneric hybridisation between Salix viminalis L. as the female and four Populus species (Populus trichocarpa, P. tremula, P. × canadensis and P. simonii) as male pollen donors was performed by in vitro stigma pollination. To overcome postzygotic barriers, transfer of hybrid embryos to new medium is necessary. We carried out detailed ultrastructural analyses to establish: (i) at which stage of embryo development the first signs of programmed cell death (PCD) could be detected; and (ii) at which stage the lack of serious or irreversible changes guaranteed that advanced development of hybrid plants could occur after embryo rescue. Transmission electron microscopy and confocal laser scanning microscopy revealed the presence of both developing and degenerating embryos. Developing globular, heart-shaped, and early cotyledonary embryos contained cells of correct ultrastructure. The only sign of intergeneric hybridisation was a delay in development for a few days, in comparison with control embryos. The earliest indicators of embryo degeneration were noted at 9 days after pollination (DAP). The most common indicators were excessive embryo vacuolisation, which was characterised by a large number of vesicles and formation of small vacuoles, as well as enlarged central vacuoles. Extended plastid thylakoids, folding of the cell wall, and autophagosomes were observed. Our detailed investigation of PCD in hybrid embryos enabled us to conclude that the embryo rescue technique was most effective in intergeneric willow × poplar crosses if applied between 9 and 16 DAP.

BackgroundThe European multicentre paediatric trials for the drug development programme of LENA (FP7 Grant agreement No. 602295); ‘Labeling of Enalapril from Neonates up to Adolescents’ require the determination of laboratory safety parameters. It was anticipated that the laboratory normal reference values and age range classifications vary depending on the clinical site. Thus, the objective was a seamless and clear depiction of the laboratory parameters to allow an adequate subsequent analysis of data.MethodsFourteen haematological and biochemical safety parameters plus the biomarker N-terminal pro-brain natriuretic peptide were considered. The laboratory normal reference values received from eight clinical sites were screened on data gaps, uncertainties, misclassifications and overlap of age range classifications. These aspects were revised. If further data were necessary for clarification the responsible person of the respective laboratory was contacted by email or telephone.ResultsData gaps and uncertainties of the laboratory normal reference values such as missing data for one sex, missing data for an age range classification, missing data for a parameter or overlap of age range classification were identified. All issues were solved by communication with the sites. Each laboratory parameter was categorized in between 1 and 23 age range classifications between an age from birth to 4744 days depending on the classification of the clinical site. Furthermore, up to 4 various units were recorded per laboratory parameter and subsequently harmonised into one unit.ConclusionThe developed seamless depiction of the laboratory parameters will allow the assessment and classification of the paediatric trial data and are essential for the adequate subsequent analysis.Disclosure(s)Samieh Farahani, Elisabeth Feles, Bjoern B. Burckhardt, Stephanie Laeer declare that there is no conflict of interest. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007–2013) under grand agreement n°602295 (LENA)

<p><strong>Abstract.</strong> The ISPRS Geospatial Week 2019 is a combination of 13 workshops organised by 30 ISPRS Working Groups active in areas of interest of ISPRS. The Geospatial Week 2019 is held from 10–14 June 2019, and is convened by the University of Twente acting as local organiser. The Geospatial Week 2019 is the fourth edition, after Antalya Turkey in 2013, La Grande Motte France in 2015 and Wuhan China in 2017.</p><p>The following 13 workshops provide excellent opportunities to discuss the latest developments in the fields of sensors, photogrammetry, remote sensing, and spatial information sciences:</p> <ul> <li>C3M&amp;amp;GBD – Collaborative Crowdsourced Cloud Mapping and Geospatial Big Data</li> <li>CHGCS – Cryosphere and Hydrosphere for Global Change Studies</li> <li>EuroCow-M3DMaN – Joint European Calibration and Orientation Workshop and Workshop onMulti-sensor systems for 3D Mapping and Navigation</li> <li>HyperMLPA – Hyperspectral Sensing meets Machine Learning and Pattern Analysis</li> <li>Indoor3D</li> <li>ISSDQ – International Symposium on Spatial Data Quality</li> <li>IWIDF – International Workshop on Image and Data Fusion</li> <li>Laser Scanning</li> <li>PRSM – Planetary Remote Sensing and Mapping</li> <li>SarCon – Advances in SAR: Constellations, Signal processing, and Applications</li> <li>Semantics3D – Semantic Scene Analysis and 3D Reconstruction from Images and ImageSequences</li> <li>SmartGeoApps – Advanced Geospatial Applications for Smart Cities and Regions</li> <li>UAV-g – Unmanned Aerial Vehicles in Geomatics</li> </ul> <p>Many of the workshops are part of well-established series of workshops convened in the past. They cover topics like UAV photogrammetry, laser scanning, spatial data quality, scene understanding, hyperspectral imaging, and crowd sourcing and collaborative mapping with applications ranging from indoor mapping and smart cities to global cryosphere and hydrosphere studies and planetary mapping.</p><p>In total 143 full papers and 357 extended abstracts were submitted by authors from 63 countries. 1250 reviews have been delivered by 295 reviewers. A total of 81 full papers have been accepted for the volume IV-2/W5 of the International Annals of Photogrammetry, Remote Sensing and Spatial Information Sciences. Another 289 papers are published in volume XLII-2/W13 of the International Archives of Photogrammetry, Remote Sensing and Spatial Information Sciences.</p><p>The editors would like to thank all contributing authors, reviewers and all workshop organizers for their role in preparing and organizing the Geospatial Week 2019. Thanks to their contributions, we can offer an excessive and varying collection in the Annals and the Archives.</p><p>We hope you enjoy reading the proceedings.</p><p>George Vosselman, Geospatial Week Director 2019, General Chair<br> Sander Oude Elberink, Programme Chair<br> Michael Ying Yang, Programme Chair</p>

<p><strong>Abstract.</strong> The ISPRS Geospatial Week 2019 is a combination of 13 workshops organised by 30 ISPRS Working Groups active in areas of interest of ISPRS. The Geospatial Week 2019 is held from 10–14 June 2019, and is convened by the University of Twente acting as local organiser. The Geospatial Week 2019 is the fourth edition, after Antalya Turkey in 2013, La Grande Motte France in 2015 and Wuhan China in 2017.</p><p>The following 13 workshops provide excellent opportunities to discuss the latest developments in the fields of sensors, photogrammetry, remote sensing, and spatial information sciences:</p> <ul> <li>C3M&amp;amp;GBD – Collaborative Crowdsourced Cloud Mapping and Geospatial Big Data</li> <li>CHGCS – Cryosphere and Hydrosphere for Global Change Studies</li> <li>EuroCow-M3DMaN – Joint European Calibration and Orientation Workshop and Workshop onMulti-sensor systems for 3D Mapping and Navigation</li> <li>HyperMLPA – Hyperspectral Sensing meets Machine Learning and Pattern Analysis</li> <li>Indoor3D</li> <li>ISSDQ – International Symposium on Spatial Data Quality</li> <li>IWIDF – International Workshop on Image and Data Fusion</li> <li>Laser Scanning</li> <li>PRSM – Planetary Remote Sensing and Mapping</li> <li>SarCon – Advances in SAR: Constellations, Signal processing, and Applications</li> <li>Semantics3D – Semantic Scene Analysis and 3D Reconstruction from Images and ImageSequences</li> <li>SmartGeoApps – Advanced Geospatial Applications for Smart Cities and Regions</li> <li>UAV-g – Unmanned Aerial Vehicles in Geomatics</li> </ul> <p>Many of the workshops are part of well-established series of workshops convened in the past. They cover topics like UAV photogrammetry, laser scanning, spatial data quality, scene understanding, hyperspectral imaging, and crowd sourcing and collaborative mapping with applications ranging from indoor mapping and smart cities to global cryosphere and hydrosphere studies and planetary mapping.</p><p>In total 143 full papers and 357 extended abstracts were submitted by authors from 63 countries. 1250 reviews have been delivered by 295 reviewers. A total of 81 full papers have been accepted for the volume IV-2/W5 of the International Annals of Photogrammetry, Remote Sensing and Spatial Information Sciences. Another 289 papers are published in volume XLII-2/W13 of the International Archives of Photogrammetry, Remote Sensing and Spatial Information Sciences.</p><p>The editors would like to thank all contributing authors, reviewers and all workshop organizers for their role in preparing and organizing the Geospatial Week 2019. Thanks to their contributions, we can offer an excessive and varying collection in the Annals and the Archives.</p><p>We hope you enjoy reading the proceedings.</p><p>George Vosselman, Geospatial Week Director 2019, General Chair<br /> Sander Oude Elberink, Programme Chair<br /> Michael Ying Yang, Programme Chair</p>

Based on the analysis of modern literature, a systematization of information of the soft tissues of the oral cavity remodeling mechanisms after surgical interventions was carried out. Priority area in modern medical practice is the development and use of such methods and drugs that combine maximum safety and high biological activity in relation to body tissues. A number of scientists have proposed and introduced into practical medicine the technology of programmed scar remodeling. According to this technique, injections of antihomotoxic substances directly around the surgical wound are required, which reduce the duration of edema in the tissues. A number of authors have studied the use of a minimally invasive microsurgical method based on fractional laser photothermolysis to initiate the regeneration of gums and oral mucosa. As a result of the study, it was found that microscopic thermal wounds in the form of damage islands surrounded by normal viable tissue contribute to stimulation of regeneration, which leads to complete restoration of the tissue without scar formation. Recently, methods of using directed tissue regeneration have been widely introduced into practice. In this technique, cellular structures are used that increase the activity of regenerative processes - fibroblasts, platelet plasma. Great importance in the processes of regeneration of the oral mucosa has the epidermal growth factor EGF. It is a globular protein, acts like a strong mitogen on cells of endodermal, ectodermal and mesodermal origin. The epidermal factor stimulates cell proliferation and, in combination with other cytokines, is a factor that accelerates wound healing and angiogenesis. For the treatment of patients with periodontal tissue damage, a number of scientists have proposed a method for using an adhesive protective wound cover created with biotechnological high molecular weight hyaluronic acid. Thus, the analysis of literary sources and the systematization of the available information proves the relevance of further studying the features of the mechanisms of remodeling of soft tissues of the oral cavity. Needs of modern maxillofacial surgery requires morphological study for improvement of existing and development of new treatments for patients.

Abstract Abstract 2781 Background. Umbilical cord blood (UCB) is a viable alternative source of allogeneic hematopoietic stem cells for the treatment of both malignant and non-malignant disease (Cairo et al BBMT 2008). UCB transplantation (UCBT) is known to be associated with decrease severe acute graft-versus-host disease (GvHD) compared to unrelated bone marrow (BM) and peripheral blood (PB) transplantation; however, it is associated with delayed hematopoietic and immune reconstitution (Szabolcs/Cairo et al Seminars in Hematology 2010). NK cells play important roles in both innate and adaptive immunity and are characterized as a CD56+ cell population. NK cell recovery is prompt by 2 months after hematopoietic stem cell transplantation (HSCT), while T-cell (after at least 9 mo HSCT) and B-cell (after 3 to 4 mo HSCT) reconstitutions are gradual and delayed. CD56+dim cells are primarily cytotoxic and make up 90% of PB NK populations (Shereck/Cairo PBC 2007). We previously demonstrated the ability to ex-vivo expand CB MNC into various phenotypes of CD56+dim and CD56+bright NK cells (totally 60%) and NKT cells (40%) with profound in vitro and in vivo cytotoxicity against hematological malignancies (Ayello/Cairo BBMT 2006 & Exp. Hematology 2009). Proteomic studies from our group demonstrated differential protein expression including ↑NKG2A, ↓IP3R type 3, ↓MAPKAPK5, and ↑NOTCH 2 in CB vs PB CD56+dim (Shereck/Cairo, ASH 2007; Shereck/Day/Cairo, ASBMT 2009). Objective. In these studies, we sought to determine the similarity or differences in genetic signatures in CB vs APB CD56+dim NK cells. Methods. CB MNCs were isolated on a ficoll gradient and NK CD56+16+dim cells isolated using a 2-step magnetic activated cell separation (MACS) process via a standard kit (Miltenyi Biotec). Enrichment was at least 94%. Isolated RNA from CB and PB CD56+dim cells were subjected to microarray studies (Affymetrix, U133A_2) as we have previously described (Jiang/Cairo et al J Immunol 2004). Data were analyzed by Agilent GeneSpring and Ingenuity pathway analyses. Welch test were used to perform statistical analysis and fold change of < 1.5 and values of p<0.05 were considered to be significant. Two-color ECL Plex fluorescence Western blotting (WB) was preformed to validate the proteomic data. Protein samples were separated using SDS-PAGE followed by transblotting. WB membranes were then incubated with target and control (GAPDH) primary antibodies. After rinse and wash, the membranes were further incubated with CY5 and CY3 conjugated secondary antibodies. The membranes were scanned with TYPHOON by green (532 laser and 580 filter) and red (633 laser and 670 filter) setting for CY3 and CY5, respectively, and then observed and quantified using ImageQuant. Results. CB vs PB CD56+dim cells significantly altered expressed 796 genes, in which 486 genes were over expressed, at the genomic level including: pro-apoptotic genes: CASP10 (3.1F), TNFSF11 (4.7F), CDC2 (3.0F), BCL2L1 (4.3F), NOTCH2 (1.5F); and cell development: PBX1 (7.6F), IL1RN (5.1F), CD24 (5.3F), CD34 (3.5F), CD55 (2.1F), CCL13 (2.2F). Conversely, there was significant under expression of NF1 (5.1F), MAP2K3 (1.7F), PIK3CD (2.1F), BAX (2.9F), and JUN (2.2F). Our WB results indicate that NOTCH2 (2.4F) and PBX1 (2.2F) proteins are increased in CB vs PB CD56+dim NK cells, consistent with our proteomic results. Conclusion. These results suggest that CB vs PB CD56+dim NK are more prone to undergo programmed cell death (apoptosis) secondary to over expression of numerous pro-apoptotic genes, and may be earlier in development (pro-NK) with over expression of the CD34 gene. Furthermore, decrease CB vs PB NK cytotoxicity maybe in part secondary to increase programmed cell death in particularly increase NOTCH2 at the genomic and proteomic levels. (The first two authors contribute equally.) Disclosures: No relevant conflicts of interest to declare.

AbstractOver the last five decades private and national energy programmes worldwide have been producing a variety of radioactive wastes. One of the safest ways of disposing of this waste is to bury it deep underground in purpose-built geological disposal facilities. Currently, there is no operating geological repository in Europe for high-level waste but the goal of the IGD-TP is that the first repository shall be fully operational before the year 2025. Several studies and experiments are ongoing at various potential repository sites in Europe with the goal to establish general approaches that can be adapted for any country in need of a geological repository.The Swedish Nuclear Fuel and Waste Management Co (SKB) in Sweden and Posiva Oy in Finland are developing a method for geological disposal of high-level long-lived nuclear waste in crystalline rock, the KBS-3 method. KBS-3V (vertical) is both organizations reference design, but KBS-3H (horizontal) emplacement is also being researched as a potential alternative. Of high importance in the development is demonstrating the technical feasibilityin situof safe and reliable construction, manufacturing, disposal and sealing of such geological disposal facilities. Parts of these demonstrations are carried out under the framework of EurAtom/FP7 and one of these projects is the LUCOEX project where SKB is demonstrating horizontal emplacement, the Multi Purpose Test (MPT), and Posiva is demonstrating vertical buffer installation processes.The MPT includes the key components of the horizontal design and comprises all essential steps; manufacturing of the full-scale components, their assembly, installation in the drift and monitoring of the early buffer evolution. The MPT installation was successfully performed in late 2013. By combining the components, an initial verification of the design implementation has been achieved. At the same time, integrating the components has meant the recognition of some design weaknesses and the design will be updated accordingly.Posiva's KBS-3V buffer installation equipment that places buffer blocks with high precision in vertical deposition holes is currently being developed and will be tested during 2014 and 2015 in real underground conditions. The machine uses vacuum lifting tools for moving the buffer blocks and laser scanning technology to position both the machine and blocks. Functionality of the concept and equipment selected will be confirmed by the tests and the installation tests will provide important information about the suitability of the selected buffer dimensions and tolerances.

Purpose This paper aims to discuss an initiative developed between, Leicestershire Partnership National Health Service Trust and Turning Point, which is the locally commissioned drug and alcohol service in Leicester, Leicestershire and Rutland. The aim was to improve outcomes for clients with dual diagnosis (co-occurring mental health and substance misuse) issues. The purpose of the change in working practice was to engage with local substance misuse agencies more effectively to improve clinical outcomes within this service user group. This was achieved through four interrelated approaches. This comprising providing an integrated service. It included building relationships with substance misuse services, providing specialist dual diagnosis clinics and the introduction of substance misuse workers onto mental health wards and group work specific to substance misuse. The outcomes included easier access to services for service users and greater uptake of service users who were moving onto substance misuse services. This led to a reduction in risk related to prescribing and fewer incidents related to prescribing changes and greater engagement in services. When service users were moving between services better communication led to prescriptions being transferred with no delay and to reduced dropout rates in service. There was improved access to substance misuse services, more referrals and take up of service taking place. There was a greater understanding by staff of co-occurring substance misuse and how to work with this client group. Closer working relationship with substance misuse services and shared skills led to greater confidence in managing this service user group. This demonstrates a cost effective service that can be replicated within similar settings. Design/methodology/approach In clinical practice, shared treatment has proved challenging in light of different service models (Laker, 2006). Substance misuse works on the premise of change comes from the individual, where recovery models in mental health offer a formalised approach. One of the challenges faced by services has been the inability for mental health services to recruit and services become overstretched (Rimmer, 2018); this gave an opportunity for a new method of working to be considered. This led to the development of a new service model. These changes were: • Improving the interface with substance misuse services to improve access to community substance misuse services for mental health clients. • To provide specialist staff within the dual diagnosis field to provide a clinic jointly with local drug and alcohol services. • Introduction of substance misuse workers as team members on acute mental health and rehab wards. • Group Substance Misuse programmes. Findings Working within an integrated model, yet maintaining separate organisations, by offering joint training and clinics has led to a greater understanding of each organisation’s work and increased engagement within the service user group.The introduction of substance misuse workers to acute and rehab mental health inpatient services encouraged service users to engage at the point of admission and to be referred into locally commissioned substance misuse services prior to the point of discharge. Engagement with staff has demonstrated better engagement with substance service by service users following discharge.For clients able to take leave assessment could take place prior to discharge. This led to an increased uptake in services. Due to no opiate substitution given on discharge decreased risk of prescribed medication overdose at point of discharge and led to increase in returning straight to substance misuse services. This meant that service users received medication quicker and the right dose and on discharge ensured reduced risk. The prescribing of Naloxone at discharge is yet to be assessed, but the risk of an overdose within seven days is well-documented and Naloxone is key in reversing this trend. This change in practice can be replicated in any mental health setting and has increased access to services for those using substances. Originality/value Is original no other services have substance workers or joint clinics across the UK. First inpatient unit to welcome patients back post-discharge to attend groups.

The Laboratory for Intense Lasers (L2I) is a research centre in optics and lasers dedicated to experimental research in high intensity laser science and technology and laser plasma interaction. Currently the laboratory is undergoing an upgrade with the goal of increasing the versatility of the laser systems available to the users, as well as increasing the pulse repetition rate. In this paper we review the current status of the laser research and development programme of this facility, namely the upgraded capability and the recent progress towards the installation of an ultrashort, diode-pumped OPCPA laser system.

AbstractAfter several decades of observations from space, direct measurements of the global threedimensional wind field remain elusive, however crucial to weather predictions. The ALADIN instrument, payload of the AEOLUS satellite (figure 1), will provide measurements of atmospheric wind profiles with global Earth coverage for the climatology and meteorology users. The AEOLUS programme is sponsored by the European Space Agency with a launch planned in 2008.ALADIN belongs to a new class of Earth Observation payloads and will be the first European Lidar in space. The instrument comprises a diode-pumped high energy Nd:YAG laser and a direct detection receiver operating on aerosol and molecular backscatter signals in parallel. In addition to the Flight Model (FM), two instrument models are developed: a Pre-development Model (PDM) and an Opto-Structure-Thermal Model (OSTM). The OSTM integration has been completed and the flight equipments are under manufacturing. This paper describes the instrument design as well as the development status. The ALADIN instrument is developed under prime contractor EADS Astrium SAS with a consortium of thirty companies.

Introduction: Cerebral palsy / MPD/is a motor and postural disorder caused by permanent brain damage that occurred at an early stage of development. Cerebral palsy is the most common cause of disability in children. The aim: To present cerebral palsy as a clinical problem and to outline the importance of physiotherapy in the treatment of cerebral palsy patients. Materials and methods: The study included 67 children with cerebral palsy (mean age was 9 years) treated and followed up for 6 months at the “Górka” Orthopaedic and Rehabilitation Hospital in Busko Zdrój. The clinical presentation was dominated by manifestations of motor and postural abnormalities resulting from upper motor neuron and corticospinal tract damage. A diagnostic survey was used as the research method. The physiotherapy and rehabilitation used in the patients consisted of kinesiotherapy (usually Bobath/NDT) and physical therapy procedures (magnetic stimulation, laser therapy, LED light therapy). The study used a survey questionnaire that collected information about problems with everyday life and functioning of cerebral palsy patients and opinions about their rehabilitation programme. Results: Follow-up data were analysed in patient groups, which were created based on the method of ambulation in children with cerebral palsy. The results emphasise the role of physiotherapy in the rehabilitation of cerebral palsy patients. Systematic motor rehabilitation contributed to an improved physical fitness and better everyday functioning. Parents of children walking with aids reported having problems with access to specialist healthcare, which resulted from the fact that they did not live close enough to an appropriate centre. Parents of non-ambulatory patients reported that they lacked financial means and parents of children who were able to walk unassisted complained of long waiting times for rehabilitation. Conclusions: 1. MPD is a difficult clinical and social problem. 2. Physical improvement procedures is an essential element in the treatment of this group of patients.

Abstract Natural musculoskeletal systems have been widely recognized as an advanced robotic model for designing robust yet flexible microbots. However, the development of artificial musculoskeletal systems at micro-nanoscale currently remains a big challenge, since it requires precise assembly of two or more materials of distinct properties into complex 3D micro/nanostructures. In this study, we report femtosecond laser programmed artificial musculoskeletal systems for prototyping 3D microbots, using relatively stiff SU-8 as the skeleton and pH-responsive protein (bovine serum albumin, BSA) as the smart muscle. To realize the programmable integration of the two materials into a 3D configuration, a successive on-chip two-photon polymerization (TPP) strategy that enables structuring two photosensitive materials sequentially within a predesigned configuration was proposed. As a proof-of-concept, we demonstrate a pH-responsive spider microbot and a 3D smart micro-gripper that enables controllable grabbing and releasing. Our strategy provides a universal protocol for directly printing 3D microbots composed of multiple materials.

Abstract Background The lace plant (Aponogeton madagascariensis) is an aquatic monocot that develops leaves with uniquely formed perforations through the use of a developmentally regulated process called programmed cell death (PCD). The process of perforation formation in lace plant leaves is subdivided into several developmental stages: pre-perforation, window, perforation formation, perforation expansion and mature. The first three emerging “imperforate leaves” do not form perforations, while all subsequent leaves form perforations via developmentally regulated PCD. PCD is active in cells called “PCD cells” that do not retain the antioxidant anthocyanin in spaces called areoles framed by the leaf veins of window stage leaves. Cells near the veins called “NPCD cells” retain a red pigmentation from anthocyanin and do not undergo PCD. While the cellular changes that occur during PCD are well studied, the gene expression patterns underlying these changes and driving PCD during leaf morphogenesis are mostly unknown. We sought to characterize differentially expressed genes (DEGs) that mediate lace plant leaf remodelling and PCD. This was achieved performing gene expression analysis using transcriptomics and comparing DEGs among different stages of leaf development, and between NPCD and PCD cells isolated by laser capture microdissection. Results Transcriptomes were sequenced from imperforate, pre-perforation, window, and mature leaf stages, as well as PCD and NPCD cells isolated from window stage leaves. Differential expression analysis of the data revealed distinct gene expression profiles: pre-perforation and window stage leaves were characterized by higher expression of genes involved in anthocyanin biosynthesis, plant proteases, expansins, and autophagy-related genes. Mature and imperforate leaves upregulated genes associated with chlorophyll development, photosynthesis, and negative regulators of PCD. PCD cells were found to have a higher expression of genes involved with ethylene biosynthesis, brassinosteroid biosynthesis, and hydrolase activity whereas NPCD cells possessed higher expression of auxin transport, auxin signalling, aspartyl proteases, cysteine protease, Bag5, and anthocyanin biosynthesis enzymes. Conclusions RNA sequencing was used to generate a de novo transcriptome for A. madagascariensis leaves and revealed numerous DEGs potentially involved in PCD and leaf remodelling. The data generated from this investigation will be useful for future experiments on lace plant leaf development and PCD in planta.

Image 1: View from Geodha Sgoilt towards the sea stacks, Uig, Isle of Lewis. Image credit: George Jaramillo.IntroductionOver the cliffs of Mangerstadh on the west coast of the Isle of Lewis, is a small plot of land called Geodha Sgoilt that overlooks the North Atlantic Ocean (Image 1). On the site is a small dirt gravel road and the remnants of a World War II listening station. Below, sea stacks rise from the waters, orange and green cliff sides stand in defiance to the crashing waves. An older gentleman began to tell me of what he believed could be located here on the site. A place where visitors could learn of the wonders of St Kilda that contained all types of new storytelling technologies to inspire them. He pointed above the ruined buildings, mentioning that a new road for the visitors’ vehicles and coaches would be built. With his explanations, you could almost imagine such a place on these cliffs. Yet, before that new idea could even be built, this gentleman and his group of locals and incomers had to convince themselves and others that this new heritage centre was something desired, necessary and inevitable in the development of the Western Isles.This article explores the developing relationships that come about through design innovation with community organisations. This was done through a partnership between an academic institution and a non-profit heritage community group as part of growing study in how higher education design research can play an active partner in community group development. It argues for the use of design thinking and innovation in improving strategy and organisational processes within non-profit organisations. In this case, it looks at what role it can play in building and enabling organisational confidence in its mission, as well as, building “beyond the museum”. The new approach to this unique relationship casts new light towards working with complexities and strategies rather than trying to resolve issues from the outset of a project. These enabling relationships are divided into three sections of this paper: First it explores the context of the island community group and “building” heritage, followed by a brief history of St Kilda and its current status, and designation as a World Heritage site. Second, it seeks the value of developing strategy and the introduction of the Institute of Design Innovation (INDI). This is followed by a discussion of the six-month relationship and work that was done that elucidates various methods used and ending with its outcomes. The third section reflects upon the impacts at the relationship building between the two groups with some final thoughts on the partnership, where it can lead, and how this can represent new ways of working together within community groups. Building HeritageCurrent community research in Scotland has shown struggles in understanding issues within community capability and development (Barker 11; Cave 20; Jacuniak-Suda, and Mose 23) though most focus on the land tenure and energy (McMorran 21) and not heritage groups. The need to maintain “resilient” (Steiner 17) communities has shown that economic resilience is of primary importance for these rural communities. Heritage as economic regenerator has had a long history in the United Kingdom. Some of these like the regeneration of Wirksworth in the Peak District (Gordon 20) have had great economic results with populations growing, as well as, development in the arts and design. These changes, though positive, have also adversely impacted the local community by estranging and forcing lower income townspeople to move away due to higher property values and lack of work. Furthermore, current trends in heritage tourism have managed to turn many rural regions into places of historic consumption (Ronström 7) termed “heritagisation” (Edensor 35). There is thus a need for critical reflection within a variety of heritage organisations with the increase in heritage tourism.In particular, existing island heritage organisations face a variety of issues that they focus too much on the artefactual or are too focused to strive for anything beyond the remit of their particular heritage (Jacuniak-Suda, and Mose 33; Ronström 4). Though many factors including funding, space, volunteerism and community capability affect the way these groups function they have commonalities that include organisational methods, volunteer fatigue, and limited interest from community groups. It is within this context that the communities of the Outer Hebrides. Currently, projects within the Highlands and islands focus on particular “grassroots” development (Cave 26; Robertson 994) searching for innovative ways to attract, maintain, and sustain healthy levels of heritage and development—one such group is Ionad Hiort. Ionad Hiort Ionad Hiort is a community non-profit organisation founded in 2010 to assist in the development of a new type of heritage centre in the community of Uig on the Isle of Lewis (“Proposal-Ionad Hiort”). As stated in their website, the group strives to develop a centre on the history and contemporary views of St Kilda, as well as, encouraging a much-needed year-round economic impetus for the region. The development of the group and the idea of a heritage centre came about through the creation of the St Kilda Opera, a £1.5 million, five-country project held in 2007, led by Scotland’s Gaelic Arts agency, Proiseact nan Ealan (Mckenzie). This opera, inspired by the cliffs, people, and history of St Kilda used creative techniques to unite five countries in a live performance with cliff aerobatics and Gaelic singing to present the island narrative. From this initial interest, a commission from the Western Isles council (2010), developed by suggestions and commentary from earlier reports (Jura Report 2009; Rebanks 2009) encouraged a fiercely contentious competition, which saw Ionad Hiort receive the right to develop a remote-access heritage centre about the St Kilda archipelago (Maclean). In 2013, the group received a plot of land from the local laird for the establishment of the centre (Urquhart) thereby bringing it closer to its goal of a heritage centre, but before moving onto this notion of remote-heritage, a brief history is needed on the archipelago. Image 2: Location map of Mangerstadh on the Isle of Lewis and St Kilda to the west, with inset of Scotland. Image credit: © Crown Copyright and Database Right (2017). Ordnance Survey (Digimap Licence).St KildaSt Kilda is an archipelago about 80 kilometres off the coast of the Outer Hebrides in the North Atlantic (Image 2). Over 2000 years of habitation show an entanglement between humans and nature including harsh weather, limited resources, but a tenacity and growth to develop a way of living upon a small section of land in the middle of the Atlantic. St Kilda has maintained a tenuous relationship between the sea, the cliffs and the people who have lived within its territory (Geddes, and Gannon 18). Over a period of three centuries beginning in the eighteenth century an outside influence on the island begin to play a major role, with the loss of a large portion of its small (180) population. This population would later decrease to 100 and finally to 34 in 1930, when it was decided to evacuate the final members of the village in what could best be called a forced eviction.Since the evacuation, the island has maintained an important military presence as a listening station during the Second World War and in its modern form a radar station as part of the Hebridean Artillery (Rocket) Range (Geddes 14). The islands in the last thirty years have seen an increase in tourism with the ownership of the island by the National Trust of Scotland. The UNESCO World Heritage Organisation (UNESCO), who designated St Kilda in 1986 and 2004 as having outstanding universal value, has seen its role evolve from not just protecting (or conserving) world heritage sites, but to strategically understand sustainable tourism of its sites (“St Kilda”). In 2012, UNESCO selected St Kilda as a case study for remote access heritage conservation and interpretation (Hebrides News Today; UNESCO 15). This was partly due to the efforts of 3D laser scanning of the islands by a collaboration between The Glasgow School of Art and Historic Environment Scotland called the Centre for Digital Documentation and Visualisation (CDDV) in 2009.The idea of a remote access heritage is an important aspect as to what Ionad Hiort could do with creating a centre at their site away from St Kilda. Remote access heritage is useful in allowing for sites and monuments to be conserved and monitored “from afar”. It allows for 3D visualisations of sites and provides new creative engagements with a variety of different places (Remondino, and Rizzi 86), however, Ionad Hiort was not yet at a point to even imagine how to use the remote access technology. They first needed a strategy and direction, as after many years of moving towards recognition of proposing the centre at their site in Uig, they had lost a bit of that initial drive. This is where INDI was asked to assist by the Highlands and Islands Enterprise, the regional development organisation for most of rural Scotland. Building ConfidenceINDI is a research institute at The Glasgow School of Art. It is a distributed, creative collective of researchers, lecturers and students specialising in design innovation, where design innovation means enabling creative capabilities within communities, groups and individuals. Together, they address complex issues through new design practices and bespoke community engagement to co-produce “preferable futures” (Henchley 25). Preferable futures are a type of future casting that seeks to strive not just for the probable or possible future of a place or idea, but for the most preferred and collectively reached option for a society (McAra-McWilliam 9). INDI researches the design processes that are needed to co-create contexts in which people can flourish: at work, in organisations and businesses, as well as, in public services and government. The task of innovation as an interactive process is an example of the design process. Innovation is defined as “a co-creation process within social and technological networks in which actors integrate their resources to create mutual value” (Russo‐Spena, and Mele 528). Therefore, innovation works outside of standard consultancy practices; rather it engenders a sense of mutual co-created practices that strive to resolve particular problems. Examples include the work that has looked at creating cultures of innovation within small and medium-sized enterprises (Lockwood 4) where the design process was used to alter organisational support (Image 3). These enterprises tend to emulate larger firms and corporations and though useful in places where economies of scale are present, smaller business need adaptable, resilient and integrated networks of innovation within their organisational models. In this way, innovation functioned as a catalyst for altering the existing organisational methods. These innovations are thus a useful alternative to existing means of approaching problems and building resilience within any organisation. Therefore, these ideas of innovation could be transferred and play a role in enabling new ways of approaching non-profit organisational structures, particularly those within heritage. Image 3: Design Council Double Diamond model of the design process. Image credit: Lockwood.Developing the WorkIonad Hiort with INDI’s assistance has worked together to develop a heritage centre that tries to towards a new definition of heritage and identity through this island centre. Much of this work has been done through local community investigations revolving around workshops and one-on-one talks where narratives and ideas are held in “negative capability” (McAra-McWilliam 2) to seek many alternatives that would be able to work for the community. The initial aims of the partnership were to assist the Uig community realise the potential of the St Kilda Centre. Primarily, it would assist in enabling the capabilities of two themes. The first would be, strategy, for Ionad Hiort’s existing multi-page mission brief. The second would be storytelling the narrative of St Kilda as a complex and entangled, however, its common views are limited to the ‘fall from grace’ or ‘noble savage’ story (Macdonald 168). Over the course of six months, the relationship involved two workshops and three site visits of varying degrees of interaction. An initial gathering had InDI staff meet members of Ionad Hiort to introduce members to each other. Afterwards, INDI ran two workshops over two months in Uig to understand, reflect and challenge Ionad Hiort’s focus on what the group desired. The first workshop focused on the group’s strategy statement. In a relaxed and facilitated space in the Uig Community Hall, the groups used pens, markers, and self-adhesive notes to engage in an open dialogue about the group’s desires. This session included reflecting on what their heritage centre could look like, as well as what their strategy needed to get there. These resulted in a series of drawings of their ‘preferred’ centre, with some ideas showing a centre sitting over the edge of the cliffs or one that had the centre be an integral component of the community. In discussing that session, one of members of the group recalled:I remember his [one of INDI’s staff] interrogation of the project was actually pretty – initially – fairly brutal, right? The first formal session we had talking about strategy and so on. To the extent that I think it would be fair to say he pissed everybody off, right? So much so that he actually prompted us to come back with some fairly hard hitting ripostes, which, after a moment’s silence he then said, ‘That’s it, you’ve convinced me’, and at that point we kind of realised that that’s what he’d been trying to do; he’d been trying to really push us to go further in our articulation of what we were doing and … why we were doing it in this particular way than we had done before. (Participant A, 2016).The group through this session found out that their strategy could be refined into a short mission statement giving a clear focus as to what they wanted and how they wanted to go about doing it. In the end, drawings, charts, stories (Image 4) were drawn to reflect on what the community had discussed. These artefacts became a key role-player in the following months of the development of the group. Image 4: View of group working through their strategy workshop session. Image credit: Fergus Fullarton-Pegg (2014). The second set of workshops and visits involved informal discussion with individual members of the group and community. This included a visit to St Kilda with members from INDI, Ionad Hiort and the Digital Design Studio, which allowed for everyone to understand the immensity of the project and its significance to World Heritage values. The initial aims thus evolved into understanding the context of self-governance for distributed communities and how to develop the infrastructure of development. As discussed earlier, existing development processes are useful, though limited to only particular types of projects, and as exemplified in the Highlands and Islands Enterprise and Western Isles Council commission, it tends to put communities against each other for limited pots of money. This existing system can be innovated upon by becoming creative liaisons, sharing and co-creating from existing studies to help develop more effective processes for the future of Ionad Hiort and their ‘preferable future’. Building RelationshipsWhat the relationship with GSA has done, as a dialogue with the team of people that have been involved, has been to consolidate and clarify our own thinking and to get us to question our own thinking across several different aspects of the whole project. (Participant A, 2016)As the quote states, the main notion of using design thinking has allowed Ionad Hiort to question their thinking and challenge preconceptions of what a “heritage centre” is, by being a critical sounding board that is different from what is provided by consultants and other stakeholders. Prior to meeting INDI, Ionad Hiort may have been able to reach their goal of a strategy, however, it would have taken a few more years. The work, which involved structured and unstructured workshops, meetings, planning events, and gatherings, gave them a structured focus to move ahead with their prospectus planning and bidding. INDI enabled the compression and focus of their strategy making and mission strategy statement over the course of six months into a one-page statement that gave direction to the group and provided the impetus for the development of the prospectus briefs. Furthermore, INDI contributed a sense of contemporary content to the historic story, as well as, enable the community to see that this centre would not just become another gallery with café. The most important outcome has been an effective measure in building relationships in the Outer Hebrides, which shows the changing roles between academic and third sector partnerships. Two key points can be deemed from these developing relationships: The first has been to build a research infrastructure in and across the region that engages with local communities about working with the GSA, including groups in North Uist, Barra and South Uist. Of note is a comment made by one of the participants saying: “It’s exciting now, there’s a buzz about it and getting you [INDI] involved, adding a dimension—we’ve got people who have got an artistic bent here but I think your enthusiasm, your skills, very much complement what we’ve got here.” (Participant B, 2016). Second, the academic/non-profit partnership has encouraged younger people to work and study in the area through a developing programme of student research activity. This includes placing taught masters students with local community members on the South Uist, as well as, PhD research being done on Stornoway. These two outcomes then have given rise to interest in not only how heritage is re-developed in a community, but also, encourages future interest, by staff and students to continue the debate and fashion further developments in the region (GSAmediacentre). Today, the cliffs of Mangerstadh continue to receive the pounding of waves, the blowing wind and the ever-present rain on its rocky granite surface. The iterative stages of work that the two groups have done showcase the way that simple actions can carve, change and evolve into innovative outcomes. The research outcomes show that through this new approach to working with communities we move beyond the consultant and towards an ability of generating a preferable future for the community. In this way, the work that has been created together showcases a case study for further island community development. We do not know what the future holds for the group, but with continued support and maintaining an open mind to creative opportunities we will see that the community will develop a space that moves “beyond the museum”. AcknowledgementsThe author would like to thank Ionad Hiort and all the residents of Uig on the Isle of Lewis for their assistance and participation in this partnership. For more information on their work please visit http://www.ionadhiort.org/. The author also thanks the Highlands and Islands Enterprise for financial support in the research and development of the project. Finally, the author thanks the two reviewers who provided critical commentary and critiques to improve this paper. ReferencesBarker, Adam. “Capacity Building for Sustainability: Towards Community Development in Coastal Scotland.” Journal of Environmental Management 75.1 (2005): 11-19. Canavan, Brendan. “Tourism Culture: Nexus, Characteristics, Context and Sustainability.” Tourism Management 53 (2016): 229-43. ———. “The Extent and Role of Domestic Tourism in a Small Island: The Case of the Isle of Man.” Journal of Travel Research 52.3 (2012): 340-52. Cape, Ruth. Exploring Growth and Empowerment of Communities in the Western Isles. Stornoway, 2013. Bullen, Elizabeth, Simon Robb, and Jane Kenway. “‘Creative Destruction’: Knowledge Economy Policy and the Future of the Arts and Humanities in the Academy.” Journal of Education Policy 19.1 (2004): 3–22. Brown, Tim, and Jocelyn Wyatt. “Design Thinking for Social Innovation.” Stanford Social Innovation Review Winter (2010): 30-35. <https://ssir.org/articles/entry/design_thinking_for_social_innovation>.Briscoe, Gerard, and Mark Plumbley. Creating Cultures of Innovation: The Digital Creative Industries. <https://qmro.qmul.ac.uk/xmlui/bitstream/handle/123456789/11403/Creating%20Cultures%20of%20Innovation.pdf?sequence=7>.Edensor, Tim. Industrial Ruins: Spaces, Aesthetics, and Materiality. Oxford: Berg, 2005. Geddes, George. The Magazine and Gun Emplacement, St Kilda A Conservation Statement. Edinburgh, 2008. Geddes, George, and Angela Gannon. St Kilda: The Last and Outmost Isle. Edinburgh: Royal Commission on the Ancient & Historical Monuments of Scotland, 2015. Gordon, Michel, and Arthur Percival. The Wirksworth Story: New Life for An Old Town. Wirksworth: Civic Trust, 1984. GSAmediacentre. “The Glasgow School of Art Contributes to St Kilda Centre Symposium in Stornoway.” GSA Media Centre, The Glasgow School of Art, 17 Aug. 2016. 6 Apr. 2017 <www.gsapress.blogspot.co.uk/2016/08/the-glasgow-school-of-art-contributes.html>.Henchley, Norman. "Making Sense of Future Studies." Alternatives 7.2 (1978): 24-28. Jacuniak-Suda, Marta, and Ingo Mose. “Social Enterprises in the Western Isles (Scotland) – Drivers of Sustainable Rural Development ?” Europa Regional 19.2011.2 (2014): 23-40. Lockwood, Joseph, Madeline Smith, and Irene McAra-McWilliam. “Work-Well: Creating a Culture of Innovation through Design.” International Design Management Research Conference, Boston, 2012. 1-11. McAra-McWilliam, Irene. “Impossible Things? Negative Capability and the Creative Imagination.” Creativity or Conformity Conference, Cardiff, 2007. 1-8. <https://www.academia.edu/1246770/Impossible_things_Negative_Capability>.McKenzie, Steven. "Opera Celebrates St Kilda History." BBC News 23 Jun. 2007. 6 Apr. 2017 <http://news.bbc.co.uk/1/hi/scotland/highlands_and_islands/6763371.stm>.McMorran, Rob, and Alister Scott. “Community Landownership: Rediscovering the Road to Sustainability.” Lairds: Scottish Perspectives on Upland Management (2013): 20-31. Maclean, Diane. “Bitter Strife over St Kilda Visitor Centre.” The Caledonian Mercury 29 Jan. 2010. 6 Apr. 2017 <http://www.caledonianmercury.com/2010/01/29/bitter-strife-over-st-kilda-visitor-centre/001383>.News Editor. “Double Boost for St Kilda Project.” Hebrides News Today 20 Nov. 2013. 6 Apr. 2017 <www.hebridestoday.com/2013/11/double-boost-for-st-kilda-project/>.Portschy, Szabolcs. “Design Partnerships between Community-Engaged Architecture and Academic Education Programs.” Pollack Periodica 10.1 (2015): 173-180.“Proposal – Ionad Hiort.” Ionad Hiort. 6 Apr. 2017 <http://www.ionadhiort.org/the-proposal>. Rebanks, James. “World Heritage Status: Is There Opportunity for Economic Gain? Research and Analysis of the Socio-Economic Impact Potential of UNESCO World Heritage Site Status.” 2009. <http://icomos.fa.utl.pt/documentos/2009/WHSTheEconomicGainFinalReport.pdf>.Robertson, Iain James McPherson. “Hardscrabble Heritage: The Ruined Blackhouse and Crofting Landscape as Heritage from Below.” Landscape Research 40.8 (2015): 993–1009. Ronström, Owe. “Heritage Production in the Island of Gotland.” The International Journal of Research into Island Cultures 2.2 (2008): 1-18. Russo‐Spena, Tiziana, and Cristina Mele. “‘Five Co‐s’ in Innovating: A Practice‐Based View.” Ed. Evert Gummesson. Journal of Service Management 23.4 (2012): 527-53. “St Kilda.” World Heritage Centre. UNESCO. 6 Apr. 2017 <www.whc.unesco.org/en/list/387/>.Steiner, Artur, and Marianna Markantoni. “Unpacking Community Resilience through Capacity for Change.” Community Development Journal 49.3 (2014): 407-25.Shortall, S. “Rural Development in Practice: Issues Arising in Scotland and Northern Ireland.” Community Development Journal 36.2 (2001): 122-33. UNESCO. Using Remote Access Technologies: Lessons Learnt from the Remote Access to World Heritage Sites – St Kilda to Uluru Conference. London, 2012. Urquhart, Frank. “St Kilda Visitor Centre in Hebrides Step Closer.” People Places, The Scotsman 20 Nov. 2013. 6 Apr. 2017 <www.scotsman.com/heritage/people-places/st-kilda-visitor-centre-in-hebrides-step-closer-1-3195287>. Watson, Amy. “Plans for St Kilda Centre at Remote World Heritage Site.” People Places, The Scotsman 16 Aug. 2016. 6 Apr. 2017 <www.scotsman.com/heritage/people-places/plans-for-st-kilda-centre-at-remote-world-heritage-site-1-4204606>.

This year has seen considerable successes for the Institute and its staff in terms of both academic research and our role in projecting the history and environmental significance of the polar regions more widely. In the physical and social sciences, and in our library, archival, and museum activities, we have secured a wide range of external grants. The acquisition of significant external funding for research in the social sciences and humanities, and for museum activities, represents an important addition to our continuing strong portfolio of competitively won research council grants relating to high-latitude environmental change. Institute staff hold grants of almost £2.5 million, and it is this external funding that has supported polar field programmes in both the natural and social sciences during 2004 in Antarctica, Greenland, Svalbard, and the Russian Far East. The information collected, using methods ranging from airborne lasers deployed over glaciers to informal discussions with native Siberian reindeer herders, will provide the basis for a number of forthcoming publications in both academic journals and books accessible to a wider readership.

Increasing evidence indicates that pyroptosis, a new type of programmed cell death, may participate in random flap necrosis and play an important role. ROS-induced lysosome malfunction is an important inducement of pyroptosis. Transcription factor E3 (TFE3) exerts a decisive effect in oxidative metabolism and lysosomal homeostasis. We explored the effect of pyroptosis in random flap necrosis and discussed the effect of TFE3 in modulating pyroptosis. Histological analysis via hematoxylin-eosin staining, immunohistochemistry, general evaluation of flaps, evaluation of tissue edema, and laser Doppler blood flow were employed to determine the survival of the skin flaps. Western blotting, immunofluorescence, and enzyme-linked immunosorbent assays were used to calculate the expressions of pyroptosis, oxidative stress, lysosome function, and the AMPK-MCOLN1 signaling pathway. In cell experiments, HUVEC cells were utilized to ensure the relationship between TFE3, reactive oxygen species (ROS)-induced lysosome malfunction and cell pyroptosis. Our results indicate that pyroptosis exists in the random skin flap model and oxygen and glucose deprivation/reperfusion cell model. In addition, NLRP3-mediated pyroptosis leads to necrosis of the flaps. Moreover, we also found that ischemic flaps can augment the accumulation of ROS, thereby inducing lysosomal malfunction and finally initiating pyroptosis. Meanwhile, we observed that TFE3 levels are interrelated with ROS levels, and overexpression and low expression of TFE3 levels can, respectively, inhibit and promote ROS-induced lysosomal dysfunction and pyroptosis during in vivo and in vitro experiments. In conclusion, we found the activation of TFE3 in random flaps is partially regulated by the AMPK-MCOLN1 signal pathway. Taken together, TFE3 is a key regulator of ROS-induced pyroptosis in random skin flaps, and TFE3 may be a promising therapeutic target for improving random flap survival.

Scientific Program Oral Presentations Authors Title Abstract CONSTANTIN MUNTEANU, Mihail HOTETEU, Diana MUNTEANU, Gabriela DOGARU - 12 minutes PERSPECTIVES OF BALNEOLOGY - INTERNATIONAL DATA INPUTS, NATIONAL OUTPUTS Link L1 UMBERTO SOLIMENE - 14 minutes CLIMATE AND HEALTH: A NEW CHALLENGE FOR AN OLD SCIENCE Link L2 Zeki KARAGÜLLE - 14 minutes BALNEOLOGICAL TREATMENTS WITH NATURAL HYDROGEN SULFIDE (H2S) Waters Link L3 Constantin Florin Dragan, Liliana Padure, Gelu Onose - 12 minutes SPECIFIC ADVANCED QUANTIFICATIONS ON THE RELATIONSHIP BETWEEN THE ANGULATION OF THE MAIN SCOLIOTIC CURVE AND LEG SWING IN THE GAIT PHASES, IN CHILDREN AND ADOLESCENTS WITH AND WITHOUT POSTURAL TREATMENT Link L4 Irina ALBADI, Camelia CIOBOTARU, Andreea-Alexandra LUPU, Ionela BALASA, Claudiu FATU, Enghin SACHIR, Gelu ONOSE - 12 minutes A MULTIMODAL APPROACHES TO MANAGE REHABILITATION THERAPY OF DISFUNCTIONALS ASPECTS TO A PACIENT WITH GOUT, MIELLITUS DIABETES, ATRIAL FIBRILATION AND MIDDLE CEREBRAL ARTERY STROKE Link L5 ELENA RAEVSCHI - 12 minutes PREVENTION CONSIDERATIONS IN Cardiovascular Diseases regarding the premature mortality reduction Link L6 ANIȘOARA CIMIL - 12 minutes THE EFFECTIVENESS OF THE REHABILITATION PROGRAMME ACCORDING TO THE ETIOPATHOGENESIS OF PROSTHETIC JOINT PATHOLOGY Link L7 TRAIAN -VIRGILIU SURDU, Monica SURDU, Olga SURDU - 10 minutes FOURTH INDUSTRIAL REVOLUTION (INDUSTRY 4.0) AND MODERN THERMAL MEDICINE (THERME 4.0) IN XXIST CENTURY Link L8 Gabriela DOGARU, Akos MOLNAR, Marieta MOTRICALA - 10 minutes EFFECTS OF CARBONATED MINERAL WATER AND MOFETTE IN BĂILE TUŞNAD IN EXPERIMENTALLY INDUCED ISCHEMIC HEART DISEASE Link L9 Q & A – 12 minutes Authors Title Abstract Aurelian Anghelescu, Valentin Deaconu, Catalina Axente,Elena Constantin, Gelu Onose - 12 minutes THERAPEUTIC DIFFICULTIES IN A YOUNG PATIENT WITH MULTIDRUG RESISTANT EPILEPSY (NEEDING VAGAL NERVE ELECTROSTIMULATION), SEQUELAE AFTER CONGENITAL VASCULAR CEREBRAL MALFORMATION, WITH CHRONIC GAIT IMPAIRMENTS AND RECENT TRAUMATIC BRAIN COMPLICATION Link L10 Luminița NIRLU, Alexandru G. STAVRICĂ, Laura Georgiana Popescu, Ana Carmen Albeșteanu, Ali-Osman Saglam, Gelu Onose - 12 minutes DIAGNOSTIC PARTICULARITIES AND MULTIMODAL THERAPEUTIC AND REHABILITATION APPROACHES TO A COMPLEX CASE OF POST ISCHEMIC STROKE WITH DYSPHAGIA AND DYSPHONIA, ASSOCIATING MILLARD-GUBLER AND WALLENBERG SYNDROMES - CASE REPORT Link L11 Cristina Octaviana DAIA, Croitoru Stefana, Mariana Axente, Gelu ONOSE - 14 minutes IONTOPHORESIS AND LASER APPLICATIONS IN FACIAL NERVE PALSY Link L12 Doina Maria MOLDOVAN, Gabriela DOGARU - 12 minutes SPLINTING VERSUS SURGICAL TREATMENT IN MALLET FINGER Link L13 Doina Maria MOLDOVAN, Gabriela DOGARU - 12 minutes EARLY REHABILITATION IN PATIENT AFTER TREATMENT FOR DISTAL RADIUS FRACTURE Link L14 Liliana PADURE, Raluca PETCU, Anca Irina GRIGORIU - 12 minutes THE IMPACT OF MULTIFACTORIAL GAIT ANALYSIS ON THE DIAGNOSIS AND REHABILITATION OF CHILDREN WITH WALKING DISORDERS Link L15 Valerica Creanga-Zarnescu, Ana-Maria Fatu, Mihaela Lungu, Violeta Sapira, Anamaria Ciubara - 12 minutes REHABILITATION POSSIBILITIES OF APHASIC PATIENT Link L16 Cristina DAIA, Simona SCHEK, Stefana CROITORU, Alina GHERGHICEANU, Gelu ONOSE - 12 minutes FAVORABLE REHABILITATION RESULTS ON A PATIENT WITH SEVERE LEFT HEMIPLEGIA AFTER AN INTRAPARENCHYMAL HEMATOMA Link L17 Elena VIZITIU, Mihai CONSTANTINESCU, Sînziana Călina SILIȘTEANU - 12 minutes THE ROLE OF THERAPEUTIC SWIMMING IN THE PROPHYLAXIS OF SCOLIOSIS IN THE "C" LEFT IN CHILDREN DURING THE PREPUBERTAL PERIOD Link L18 Q & A – 12 minutes Authors Title Abstract Alexandru G. STAVRICĂ, Luminiţa Nirlu, Laura Georgiana Popescu, Ana Carmen Albeşteanu, Gelu ONOSE - 12 minutes DIAGNOSTIC AND THERAPEUTIC APPROACHES IN REHABILITATION CORRELATED TO A CASE OF TETRAPARESIS (WITH PREDOMINANCE OF PARAPARESIS) AFTER SEVERE CCT - BIFRONTO - BASAL AND BITEMPORAL CONTUSION. Link L19 Ana Maria Bumbea, Otilia Rogoveanu, Carmen,Albu Rodica Traistaru, Catalin,Bostina, Bogdan Stefan Bumbea, Roxana Dumitrascu, Borcan Madalina MANAGEMENT OF SPASTICITY IN NEUROLOGICAL PATIENTS Link L20 Laura Georgiana Popescu, Luminița Nirlu, Ana Carmen Albeșteanu, Ali Osman Saglam, Gelu Onose - 12 minutes PARTICULARITIES OF COMPLEX THERAPEUTICALLY-REHABILITATIVE MANAGEMENT, STEPWISE, IN A PATIENT WITH POST-CCT PSYCHO-COGNITIVE IMPAIRMENT IN A LARGE POLYTRAMATIC CONTEXT - CASE REPORT Link L21 Adrian MELNIC, Oleg PASCAL - 12 minutes DEVELOPING STRATEGIES TO ADDRESS COMORBIDITY IN STROKE REHABILITATION. Link L22 Dorin-Gheorghe TRIFF, Simona POP - 12 minutes MONOGENIC DISEASES WITH MUSCULO ARTICULAR LAXITY. DIAGNOSTIC CRITERIA AND PRINCIPLES OF RECOVERY THERAPY Link L23 Catalin Ionite, Dragos Arotaritei, Mihai Ilea, Mariana Rotariu - 12 minutes THE USE OF ELASTIC BANDS IN THE RECOVERY OF ANKLE SPRAINS Link L24 Mariana Rotariu, Marius Turnea, Calin Corciova, Catalin Ionite - 12 minutes THE EFFECTS OF CUBE THERAPY IN THE RECOVERY OF THE ARTHROSIS HAND IN GERIATRICS Link L25 Cristian Ştefan LIUŞNEA - 12 minutes FITNESS AND WELLNESS. CONCEPTUAL DELIMITATIONS Link L26 Adriana LUPU - 12 minutes NSAID THERAPY OF MUSCULOSKELETAL PAINS AND ITS PARTICULARITIES IN THE PATIENTS SUFFERING FROM CARDIOVASCULAR DISORDERS Link L27 Q & A – 12 minutes Authors Title Abstract Mihaela MANDU, Cristinel Dumitru BADIU, Raluca PETCU, Cosmin OPREA, Gelu ONOSE - 12 minutes CLINICAL-EVOLUTIVE PARTICULARITIES AND A MULTIMODAL THERAPEUTIC-REHABILITATIVE, AS WELL AS THROUGH CONNECTED CARES, APPROACH, IN A CASE OF HEMIPLEGIA AFTER ISCHEMIC CARDIO-EMBOLIC STROKE WITHIN A POLYPATHOLOGICAL CONTEXT Link L28 Ana Carmen Albesteanu, Laura Georgiana Popescu, Luminița Nirlu, Ali Osman Saglam, Gelu Onose - 12 minutes MULTIMODAL - REHABILITATIVE THERAPEUTICAL APPROACHES IN A COMPLEX OF PATHOLOGY INCLUDING POSSIBLY EVOLVING DISCARIOTIC TYPE - CASE REPORT Link L29 Liliana PADURE, Cristian Adam, Laura Fierbinteanu - 12 minutes ATTACHMENT - PROGNOSTIC FACTOR IN MEDICAL RECOVERY Link L30 Prof. Alexandru Vlad Ciurea - 20 minutes MOTILITY OR MORBIDITY IN NEUROSURGERY Link L31 Valerica CREANGA-ZARNESCU, Ana-Maria FATU, Anamaria CIUBARA, Violeta SAPIRA,Aurelia ROMILA, Mihaela LUNGU - 12 minutes EXERCISES PROGRAM AND REHABILITATION IN PARKINSON’S DISEASE Link L32 Irina VERINCEANU,Alice MUNTEANU, Andreea STOICA, Stefan ISPAS - 12 minutes THE CARDIAC REHABILITATION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Link L33 Marius Turnea, Catalin Ionite, Mihai Ilea, Dragos Arotaritei - 12 minutes STATISTICAL ANALYSIS OF PHYSIOTHERAPEUTIC MEANS USED IN THE RECOVERY OF MUSCLE INJURIES IN ATHLETES Link L34 Mihaiela CHICU, Eugen BITERE - 10 minutes THE ROLE OF IL1β IN CARTILAGINOUS DISTRUCTION IN RHEUMATOID ARTHRITIS Link L35 Mihaiela CHICU, Eugen BITERE - 10 minutes THE ROLE OF THE INFLAMMASOMS IN THE PATHOGENESIS OF INFLAMMATORY REACTION Link L36 Q & A – 8 minutes Authors Title Abstract Prof. Dr. Gelu Onose, (Keynote Speaker) Vlad Ciobanu, Corina Sporea - 20 minutes A TOPICAL SYSTEMATIC LITERATURE REVIEW AND REAPPRAISAL ON ESSAYS TOWARDS SYSTEMATIZING CLINICAL ASSESSMENT INSTRUMENTS USED TO EVALUATE NEURO-functional deficits after spinal cord injuries, mainly in adults, including through the ICF(-DH) conceptual framework Link L37 Diana-Elena SERBAN, Aurelian ANGHELESCU, Elena CONSTANTIN, Gelu ONOSE - 12 minutes THE ACQUISITION OF SELF-DEFENSE TECHNIQUES AND PROCEDURES AGAINST THE ACT OF AGGRESSION IN THE PACIENT WITH PARAPLEGIA, WHEEL-CHAIR INDEPENDENT Link L38 Aurelian Anghelescu, Elena Constantin, Anca Sanda Mihaescu, Gelu Onose - 12 minutes “PREVENTION IS CURE, EDUCATION IS ESSENTIAL” - RESPONSIBLE IMPLICATION OF YOUNG PEOPLE IN EDUCATIONAL AND PROPHYLACTIC ACTIONS AGAINST ACCIDENTAL CERVICAL SPINAL CORD INJURY AND SEVERE DISABILITIES BY DIVING IN UNVERIFIED WATERS. Link L39 Alexandra SPORICI, Irina ANGHEL, Lapadat MAGDALENA, Gelu ONOSE - 12 minutes RECOVERABLE RESULTS AT A PATIENT WITH AIS/FRANKEL D INCOMPLETE TETRAPLEGIA / POST SPINAL CORD INJURY BY FALLING FROM A HEIGHT, ON AN ANKYLOSING SPONDYLITIS BACKGROUND Link L40 Ioana ANDONE, Carmen CHIPĂRUȘ, Andreea FRUNZA, Aura SPÎNU, Simona STOICA, Liliana ONOSE, George PATRASCU, Gelu ONOSE -12 minutes CLINICAL, PARACLINICAL ASPECTS AND COMPLEX THERAPEUTICAL APPROACHES IN A PATIENT WITH INCOMPLETE PARAPLEGIA, POST THORACIC MENIGIOMA SURGICALLY TREATED, IN NEUROFIBROMATOSIS CONTEXT Link L41 Cristina Octaviana DAIA, Alina-Elena Gherghiceanu, Helene Ivan, Gelu ONOSE - 12 minutes RESEARCH ON NEUROREHABILITATION RESULTS IN VERTEBRO-MEDULLARY POST-TRAUMATIC CONDITIONS ASSOCIATING FRACTURES, IN A POLITRAMATIC CONTEXT Link L42 Ali-Osman Saglam, Alexandru G. Stavrica, Ana Carmen Albeşteanu, Laura Georgiana Popescu, Luminita Nirlu, Gelu Onose - 12 minutes MEDICAL-REHABILITATION ENDEAVORS, CARE INTERVENTIONS AND CONNOTATIONS OF A MEDICO-SOCIAL TYPE, IN A COMPLEX POLYPATHOLOGICAL CASE: PARAPLEGIA, SPONDYLODISCITIS, KIDNEY FAILURE IN THE HAEMODIALYSIS STAGE AND BILATERAL NEPHROSTOMIES AFTER SURGICALY TREATTED BLADDER NEOPLASM. Link L43 Sorina Petrușan-Dunca, Liviu Lazăr, Tiberiu-Dorin Corha - 12 minutes INDICATIONS AND LIMITIS OF REHABILITATION TREATMENT FOR LUMBAR DISCOPATHY IN PREGNACY Link L44 Q & A – 8 minutes Authors Title Abstract Elena Silvia SHELBY, Mihaela AXENTE, Liliana PĂDURE - 12 minutes CHARCOT MARIE TOOTH DISEASE. CASE PRESENTATION. GENETIC DISEASES WHICH REQUIRE physical rehabilitation Link L45 Link L46 Simona Carniciu - 12 minutes Influence of nutrition and exercise on the use of different energy substrates in the prevention of metabolic diseases Link L81 Simona-Isabelle STOICA, Carmen Elena CHIPĂRUȘ, Magdalena Vasilica LAPADAT, George PĂTRAȘCU, Gelu ONOSE - 12 minutes CLINICAL-THERAPEUTIC AND RECUPERATORY FEATURES IN A PATIENT WITH PLURIPATOLOGY: ISCHEMIC STROKE, ISCHEMIC HEART DISEASE (SECHELAR MYOCARDIAL INFARCTION), CHRONIC KIDNEY DISEASE AND MONSTROUS GOUT- CASE PRESENTATION Link L47 Eugen BITERE, Mihaiela CHICU - 12 minutes PATHOPHYSIOLOGY OF ATHEROGENESIS AND CARDIOVASCULAR RISK IN CHRONIC INFLAMMATORY DISEASES Link L48 Victoria CHIHAI, Alisa TĂBÎRȚĂ, Anastasia ROTĂREANU, Vladlena MIHAILOV, Mihail CÎRÎM - 12 minutes THE IMPACT OF ACTIVE KINETIC PROGRAMS ON CLINICAL AND FUNCTIONAL STATUS ADRESSED TO PEOPLE WITH DIABETIC ANGIOPATHY Link L49 Ana-Maria Fătu, Ana Maria Pâslaru, Valerica Creangă-Zărnescu, Alexandru Nechifor, Mădălina Verenca, Mihaela Lungu, Anamaria Ciubară - 12 minutes THE IMPACT OF COGNITIVE DECLINE ON STROKE REHABILITATION Link L50 Alisa TĂBÎRŢĂ, Victoria CHIHAI - 12 minutes THE USE OF TRINITY AMPUTATION AND PROSTHESIS EXPERIENCE SCALES IN THE COMPLEX REHABILITATION OF PERSONS WITH LOWER LIBM AMPUTATION Link L51 Ilie ONU, Mariana ROTARIU, Elvina MIHALAȘ, Călin CORCIOVĂ - 12 minutes STUDY ON EFFICIENCY OF ELECTROTHERAPY AND PHYSIOTHERAPY MANAGEMENT ON HERNIATED LUMBAR DISC Link L52 María G. Souto Figueroa, Antonio Freire Magariños RESEARCH - SURVEY TO 142 THERMALIST WHO HAVE PERFORMED A THERMAL CURE AT THE BATHS OF BAÑOS DE MOLGAS (OURENSE) AND AUGAS SANTAS (LUGO) - GALICIA – SPAIN Link L53 Q & A – 12 minutes Authors Title Abstract Irina Ionica - 12 minutes ACUPUNCTURE IN REHABILITATION - A GENERAL VIEW Link L54 Denisa COAJĂ, Gabriela DOGARU - 12 minutes THE HEALTH BENEFITS OF FINNISH SAUNA BATHING Link L55 Otilia ROGOVEANU, Florin GHERGHINA , Rodica TRAISTARU - 12 minutes SPINA BIFIDA – FUNCTIONAL REHABILITATION METHODS IN CHILDREN Link L56 Mihaela DUTESCU, Raluca OLTEAN, Petru NENADICI - 12 minutes GEOAGIU BAI RESORT - OUR EXPERIENCE OF MEDICAL REHABILITATION TREATMENT Link L57 Dumitru MIHĂILĂ, SILISTEANU Sinziana Calina, ȚICULEANU Mihaela (Ciurlică) - 12 minutes THE METEOROLOGICAL COMPLEX AND THE HUMAN PATHOLOGY. CASE STUDY – SUCEAVA COUNTY Link L58 Mariana VARODI, Gabriela DOGARU - 12 minutes EFFICACY OF NATURAL THERAPEUTIC FACTORS FROM OCNA SIBIULUI SPA RESORT IN GONARTHROSIS Link L59 Boróka-Panna GÁSPÁR, Gabriela DOGARU - 12 minutes BONE HYDRATION AND MINERAL WATERS Link L60 CALIN BOCHIS, LIVIU LAZAR, HORAȚIU URECHESCU, CARMEN NISTOR-CSEPPENTO, FELICIA CIOARA, NICOLETA PASCALAU, ALIN BOCHIS , DIANA IOVANOVICI - 12 minutes CORRELATION OF VAS PAIN SCORE WITH FUNCTION AT THE PACIENTS WITH TEMPOROMANDIBULAR OSTEOARTHRITIS Link L61 Marian Romeo CALIN, Ileana RADULESCU, Mihaela Antonina CALIN, Elena Roxana ALMASAN - 12 minutes RADIOMETRIC ASSESSMENT OF PELOID AND SALT WATER USED FOR THERAPY AND BALNEARY TRATAMENT FROM TECHIRGHIOL LAKE, ROMANIA Link L62 Q & A – 12 minutes Authors Title Abstract Cristina PETRESCU - 12 minutes EFFICACY NATURAL THERAPEUTIC FACTORS FROM BAILE GOVORA IN BRONCHIAL ASTHMA Link L63 PARASCHIVA POSTOLACHE - 12 minutes PULMONARY REHABILITATION SAVES LIVES AND IMPROVES LIFE Link L64 DOINA-CLEMENTINA COJOCARU, PARASCHIVA POSTOLACHE - 12 minutes ASSESSMENT OF DYSPNEA IN PULMONARY REHABILITATION PRACTICE Link L65 PARASCHIVA POSTOLACHE, CRISTINA LACATUSI - 12 minutes HELIOTHERAPY, CLIMATOTHERAPY AND PATIENTS WITH RESPIRATORY DISEASES Link L66 CONSTANTIN MUNTEANU, DIANA MUNTEANU, MIHAIL HOTETEU - 12 minutes BIOLOGICAL INSIGHTS OF SPELEOTHERAPY Link L67 PARASCHIVA POSTOLACHE, CRISTINA LACATUSI, DOINA-CLEMENTINA COJOCARU - 12 minutes AEROSOLS AND BREATHING Link L68 PARASCHIVA POSTOLACHE, MADALINA ZEBEGA - 12 minutes RESPIRATORY MUSCLE TRAINING AND RESPIRATORY REHABILITATION Link L69 CRISTI FRENȚ, GEORGETA MAIORESCU - 12 minutes DEVELOPMENTS AND INVOLUTIONS OF TOURISM IN THE SPA RESORTS IN ROMANIA AND THE CASE STUDY FOR LACUL SĂRAT RESORT Link L70 Dragos Arotaritei, Andrei Gheorghita, Mariana Rotariu, Marius Turnea - 12 minutes MATHEMATICAL MODEL OF SULPHUR ABSORPTION PROCESS, A POSSIBLE APPLICATION IN CURE WITH SULPHUROUS MINERAL WATER Link L71 Q & A – 12 minutes Authors Title Abstract Mihai Ciocanu, Anișoara Cimil - 12 minutes THE EFFICIENCY OF THE REHABILITATION SERVICE IN HOSPITAL CONDITIONS Link L72 Sinziana Calina SILIȘTEANU, Andrei Emanuel SILIȘTEANU - 12 minutes TRIAL ON THE WATER CONSUMPTION BY THE PERSONS IN THE GROUP AGED 19-30 YEARS Link L73 Liviu Lazăr, Florin Marcu, Felicia Cioară, Carmen Nistor Csepentö - 12 minutes MANAGEMENT OF SPECIAL ARTERIAL DISEASES Link L74 Mihaela-Carmen SUCEVEANU, Paul-Nicolae SUCEVEANU - 12 minutes EVOLUTION OF CARDIOVASCULAR RISK FACTORS AFTER MORE THAN 2 PERIODIC HOSPITALIZATIONS IN THE COVASNA HOSPITAL FOR CARDIOVASCULAR REHABILITATION Link L75 Mihaela DUTESCU, Adina TRAILA, Margit SERBAN, Emilia URSU, Dorina MIU, Ioana MALITA, Bianca CIRESAN - 12 minutes THE EFFICIENCY OF MEDICAL REHABILITATION TREATMENT IN PATIENTS WITH HEMOPHILIA AFTER SURGICAL ORTHOPEDIC INTERVENTIONS - THE EXPERIENCE OF "CRISTIAN SERBAN" BUZIAS CENTER Link L76 Dorin-Gheorghe TRIFF, Simona POP - 12 minutes PRECURSORS OF BALENOLOGY EDUCATION IN ROMANIA Link L77 Dr. Eugenia Dumitrescu, Dr. Carmen Enescu - 12 minutes ANTIALLERGIC PROCEDURES MOST COMMONLY USED IN PHYSICAL RECOVERY MEDICINE AND BALNEOLOGY Link L78 Mihail HOTETEU, Constantin MUNTEANU, Diana MUNTEANU, Gabriela DOGARU - 12 minutes PELOIDS - PERSPECTIVES ON RESEARCH AND FUTURE PLANS Link L79 Liliana Stanciu, Daniela Profir, Viorica Marin, Doinița Oprea, Elena Ionescu, Elena Almășan, Carmen Oprea - 12 minutes THE SCIENCE OF AGING WELL Link L80 Q & A – 12 minutes POSTER SESSION Authors Title Abstract Andra Pintilie, Liliana Pădure, Andrada Mirea, Corina Sporea Proprioceptive Functional Vibration Stimulation as therapeutic tool in spasticity management of jump gait pattern of spastic diplegic children with cerebral palsy Poster 1 Andra Pintilie, Liliana Pădure, Andrada Mirea, Corina Sporea Modern computerized techniques for gait’s functional evaluation through a specialized wireless inertial sensor – premise for orthopedic corrective shoes wear in children with gait disorders secondary to Cerebral Palsy Poster 2 Ana Maria PÂSLARU, Ana Maria FĂTU, Anamaria CIUBARĂ The role of medical recovery in oncology Poster 3 Maria Veronica MORCOV, Liliana PADURE, Cristian Gabriel MORCOV, Gelu ONOSE Exercises availed by sensor-based computer advanced devices: part of the interactive cognitive recovery – adjuvant of the therapy applied in the Centrul National Clinic de Recuperare Neuropsihomotorie Copii “Dr. N. Robanescu” Poster 4 Avram Mihai, Liliana Padure, Gelu Onose Theoretical fundamentals and conceptual premise for advanced proprioceptive and sensory stimulus apparatus, with sequential evaluation for the treatment of the recuperator in the equilibrium disorder, from Cerebral Palsy (PC) casuistry. Poster 5 Andrada MIREA, Gelu ONOSE, Madalina LEANCA, Florin-Petru GRIGORAS, Mihaela AXENTE, Liliana PADURE, Corina SPOREA Respiratory management in patients with rare progressive neuromuscular diseases Poster 6 Mihaela MANDU, Elena CONSTANTIN, Cristinel Dumitru BADIU, Cosmin Daniel OPREA, Cristina DAIA, Gelu ONOSE Presentation od the Fugl Meyer Assesment scale and related suggesttion in order to enhance its level of implementation in inner neurorehabilitation units Poster 7 ALEXANDRU BOGDAN-CĂTĂLIN, ALINA SIMONA ȘOVREA, ANNE-MARIE CONSTANTIN, ADINA BIANCA BOȘCA, CARMEN GEORGIU, MONICA POPA Complex oral rehabilitation in an elderly patient with periodontal disease who exercises regularly Poster 8 Dorin-Gheorghe TRIFF, Simona POP MORBIDITY BY OSTEO-MUSCULO-ARTICULAR DISEASES IN THE OCCUPATIONAL ENVIRONMENT IN MARAMURES COUNTY. THE IMPORTANCE OF MEDICAL RECOVERY AND RECORDS THROUGH ELECTRONIC DATA MANAGEMENT SYSTEMS Poster 9 Authors Title Abstract Mihaela Antonina CALIN, Marian Romeo CALIN, Constantin Munteanu New evidence on the effects of pelotherapy on local microcirculation Poster 10 Izabela Lazar, Gabriela Dogaru The effectiveness of balnear treatment in the management of psoriasis Poster 11 Dorin-Gheorghe TRIFF, Mușata Dacia BOCOȘ CORRELATIONS OF OSTEOMUSCULO-ARTICULAR DISEASES WITH WORK ABILITY, PERCEIVED SELF EFFICACY AND OCCUPATIONAL STRESSORS AT A REGULAR MEDICAL CHECK-UP IN PRE-UNIVERSITY EDUCATION UNITS Poster 12 Doroteea Teoibas-Serban, Valentin Stan, Dan Blendea PREVENTION OF LUMBAR DISC HERNIATION IN YOUNG ADULT POPULATION: A PRACTICAL APPROACH Poster 13 Călin Corciovă, Cătălina Luca, Robert Fuior, Flavia Corciovă Development a Monitoring Device for Arm Rehabilitation Poster 14 Simona Daniela Zavalichi, Marius Andrei Zavalichi, Sorin Stratulat, Florin Mitu Cardiovascular rehabilitation: challenges in a case of acute myocardial infarction and familial hypercholesterolemia Poster 15 Simona-Isabelle STOICA, Ioana TANASE, Gelu ONOSE Influences and consequences resulting in addictions in general and to chronic alcoholism, especially for patients with spinal cord injury Poster 16 Roxana Dumitrascu, Ana Maria Bumbea, Carmen Albu, Otilia Rogoveanu, Catalin Bostina, Rodica Traistaru, Borcan Madalina BIOMECHANICAL DYSFUNCTIONS OF THE FOOT – MAJOR IMPACT ON THE KINETIC CHAIN Poster 17 Otilia Rogoveanu, Gherghina Florin, Caimac Dan, Trifu Ramona, Cruceru Andra, Beldie C Medical rehabilitation in post-stroke spastic hemiparesis in young patients Poster 18 Ana Maria Bumbea, Otilia Rogoveanu, Roxana Dumitrascu, Bogdan Stefan Bumbea, Catalin Bostina, Albu Carmen, Borcan Madalina PERIPHERAL MAGNETIC STIMULATION - A CHALLENGE IN VERTEBRAL POSTTRAUMATIC RECOVERY Poster 19 Authors Title Abstract Dănuţ PĂCURAR, Mihaela Ramona PĂCURAR KNEE ARTHROPLASTY RECOVERY OF AN CANCER PATIENT Poster 20 Dănuţ PĂCURAR, Mihaela Ramona PĂCURAR THE IMPACT OF OSTEOARTICULAR PATHOLOGY IN POSTSTROKE RECOVERY Poster 21 Borcan Madalina, Bumbea Ana Maria, Bostina Catalin, Radoi Georgeta, Bumbea Bogdan EFFICIENT REHABILITATION TREATMENT IN A CASE WITH MAV-RUPTA MALFORMATION Poster 22 Demirgian Sibel, Nan Simona, Lulea Adela, Lascu Ioana, Marin Viorica Is possible the management of synovial chondromatosis of the hip by arthroscopy or complex balneal treament? Poster 23 Mădălina Codruța Verenca, Sorina Mierlan, Claudiu Elisei Tanase The Efficiency of Medical Treatment of Scoliosis – Paediatrics Poster 24 Florentina NASTASE¹, Alin Laurentiu TATU², Madalina Codruta VERENCA¹ Orthopaedic manifestations of Neurofibromatosis type 1 – case report Poster 25 Simona CARNICIU, Anatolie BACIU, Vasile FEDAS The attenuation of energy metabolic misbalance by means of aerobic, hypoxic, hypothermal adaptation and environment optimization at recreation resort center Poster 26 Irina Anghel, Alexandra Sporici, Magdalena Lapadat, Gelu Onose Complex clinical and therapeutic rehabilitation approach of a patient with Complete AIS/Frankel A quadriplegia post cervical spinal cord injury after accidental fall off a trailer and multiple complications occurring during disease progression - case study Poster 27 Ana-Maria Pelin , Monica Georgescu , Cristina Stefanescu , Costinela Georgescu Molecular treatment strategies in osteoporosis Poster 28