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Journal articles on the topic 'Laser desorption ionization MS'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Castellanos-Garcia, Laura J., Kristen N. Sikora, Jeerapat Doungchawee, and Richard W. Vachet. "LA-ICP-MS and MALDI-MS image registration for correlating nanomaterial biodistributions and their biochemical effects." Analyst 146, no. 24 (2021): 7720–29. http://dx.doi.org/10.1039/d1an01783g.

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Laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) imaging and matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) can measure distributions of elements and biomolecules in tissue sections.

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2

Tata, Alessandra, Anna Maria A. P. Fernandes, Vanessa G. Santos, Rosana M. Alberici, Dioneia Araldi, Carlos A. Parada, Wellington Braguini, et al. "Nanoassisted Laser Desorption-Ionization-MS Imaging of Tumors." Analytical Chemistry 84, no. 15 (July 16, 2012): 6341–45. http://dx.doi.org/10.1021/ac301202q.

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3

Sholokhova, Anastasiya Yu, Svetlana A. Borovikova, Sergey A. Prikhod'ko, and Alexey K. Buryak. "Ionization of ionic liquids under laser desorption/ionization." Сорбционные и хроматографические процессы 20, no. 5 (November 25, 2020): 565–71. http://dx.doi.org/10.17308/sorpchrom.2020.20/3048.

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Despite various studies of ILs as MALDI matrices, however, so far no relationship has been foundbetween the composition of ILs and their ability to serve as «good» matrices. For a preliminary experiment,in order to evaluate the characteristics of ILs before being used as a matrix in MALDI-MS, it is necessary tostudy the mass spectral behavior for the matrices themselves under LDI conditions. Therefore, the purpose of this work was to analyse ion liquids based on the cation imidazolium in combination with different types ofanions by the LDI method. Ionic liquids were synthesized in the Laboratory of catalytic processes for thesynthesis of organoelement compounds of G.K. Boreskov Institute of catalysis SB RAS (Novosibirsk). Itshould be noted that this ionic liquid was first synthesized in this Laboratory. Analyses were performed usinga Bruker UltraFlex II time of-flight mass spectrometer. Eleven ion liquids based on substituted cation imidazolium in combination with different types of anions were analysed by method laser desorption/ionization in the paper. In all mass spectra of ionic liquids obtained in the positive ion mode, cation produced a major peak and its fragmented ions. Homologous series characterized by the loss of the methyl group have been recorded. According to the more stable carbon-carbon or nitrogen bond in the heterocyclic system than in the carbon-carbon bond in the aliphatic, ion peaks are observed in the mass spectra, characteristic of the loss of methyl fragments from the aliphatic chain. In the LDI spectra obtained in the negative ion mode, the signals of the anions of ionic liquids and their fragments were observed. The combined use of the spectra obtained in positive and negative mode makes it possible to increase the reliability of identification. This makes it possible to use the revealed patterns of fragmentation for the structural analysis of ionic liquids. The analyzed ILs can be used as MALDI matrices, because they do not form dimers, assassinates, are characterized by the absence of adducts with metal ions, which is important for their further use as matrices. BMIMC6F5BF3 was first described by the LDI-MS method. It was shown that the observed fragmentation of the molecular ion of this IL is typical for most ILs with similar cations.

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Vidová, Veronika, Michael Volný, Karel Lemr, and Vladimír Havlíček. "Surface analysis by imaging mass spectrometry." Collection of Czechoslovak Chemical Communications 74, no. 7-8 (2009): 1101–16. http://dx.doi.org/10.1135/cccc2009028.

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A review of four MS-based techniques available for molecular surface imaging is presented. The main focus is on the commercially available mass spectrometry imaging techniques: secondary ion mass spectrometry (SIMS), matrix assisted laser desorption ionization mass spectrometry (MALDI-MS), desorption electrospray ionization mass spectrometry (DESI-MS) and laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS). A short historical perspective is presented and traditional desorption ionization techniques are also briefly described. The four techniques are compared mainly with respect to their usage for imaging of biological surfaces. MALDI is evaluated as the most successful in life sciences and the only technique usable for imaging of large biopolymers. SIMS is less common but offers superior spatial lateral resolution and DESI is considered to be an emerging alternative approach in mass spectrometry imaging. LA-ICP ionization is unbeatable in terms of limits of detection but does not provide structural information. All techniques are considered extremely useful, representing a new wave of expansion of mass spectrometry into surface science and bioanalysis. A minireview with 121 references.

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5

Santos, Inês C., Zacariah L. Hildenbrand, and Kevin A. Schug. "Applications of MALDI-TOF MS in environmental microbiology." Analyst 141, no. 10 (2016): 2827–37. http://dx.doi.org/10.1039/c6an00131a.

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6

Prysiazhnyi, Vadym, Filip Dycka, Jiri Kratochvil, Vitezslav Stranak, and Vladimir N. Popok. "Effect of Ag Nanoparticle Size on Ion Formation in Nanoparticle Assisted LDI MS." Applied Nano 1, no. 1 (August 24, 2020): 3–13. http://dx.doi.org/10.3390/applnano1010002.

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Metal nanoparticles (NPs) were reported as an efficient matrix for detection of small molecules using laser desorption/ionization mass spectrometry. Their pronounced efficiency is mostly in desorption enhancement, while, in some cases, NPs can facilitate charge transfer to a molecule, which has been reported for alkali metals and silver. In this work, we present the study of the influence of Ag NP size on the laser desorption/ionization mass spectra of a model analyte, the molecule of riboflavin. The NPs were produced by magnetron sputtering-based gas aggregation in a vacuum and mass-filtered before the deposition on substrates. It was found that the utilization of smaller Ag NPs (below 15 nm in diameter) considerably enhanced the molecule desorption. In contrast, the laser irradiation of the samples with larger NPs led to the increased ablation of silver, resulting in [analyte + Ag]+ adduct formation.

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Ali, Arslan, Najia Shahid, and Syed Ghulam Musharraf. "Application of dyes as doping agents in MALDI-MS matrices for the signal enhancement of proteins." RSC Advances 7, no. 11 (2017): 6598–604. http://dx.doi.org/10.1039/c6ra27156a.

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8

Wang, Chia-Chen, Yin-Hung Lai, Yu-Meng Ou, Huan-Tsung Chang, and Yi-Sheng Wang. "Critical factors determining the quantification capability of matrix-assisted laser desorption/ionization– time-of-flight mass spectrometry." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, no. 2079 (October 28, 2016): 20150371. http://dx.doi.org/10.1098/rsta.2015.0371.

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Quantitative analysis with mass spectrometry (MS) is important but challenging. Matrix-assisted laser desorption/ionization (MALDI) coupled with time-of-flight (TOF) MS offers superior sensitivity, resolution and speed, but such techniques have numerous disadvantages that hinder quantitative analyses. This review summarizes essential obstacles to analyte quantification with MALDI-TOF MS, including the complex ionization mechanism of MALDI, sensitive characteristics of the applied electric fields and the mass-dependent detection efficiency of ion detectors. General quantitative ionization and desorption interpretations of ion production are described. Important instrument parameters and available methods of MALDI-TOF MS used for quantitative analysis are also reviewed. This article is part of the themed issue ‘Quantitative mass spectrometry’.

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9

Morris, Nicholas J., Heather Anderson, Brian Thibeault, Akos Vertes, Matthew J. Powell, and Trust T. Razunguzwa. "Laser desorption ionization (LDI) silicon nanopost array chips fabricated using deep UV projection lithography and deep reactive ion etching." RSC Advances 5, no. 88 (2015): 72051–57. http://dx.doi.org/10.1039/c5ra11875a.

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10

Dong, Jinlan, Wenjing Ning, Daniel J. Mans, and Jamie D. Mans. "A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS." Analytical Methods 10, no. 6 (2018): 572–78. http://dx.doi.org/10.1039/c7ay02583a.

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A mixture of α-cyano-4-hydroxycinnamic acid and 1,5-diaminonaphthalene was discovered as a novel binary matrix for the qualitative analysis of 14 small-molecule (∼250–550 Da) cardiovascular drugs by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and MS/MS in either positive or negative ion mode.

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11

Karas, M. "Matrix-assisted laser desorption ionization MS: a progress report." Biochemical Society Transactions 24, no. 3 (August 1, 1996): 897–900. http://dx.doi.org/10.1042/bst0240897.

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12

West, Raymond E., Eric W. Findsen, and Dragan Isailovic. "Fluorophore-assisted laser desorption/ionization-mass spectrometry (FALDI-MS)." International Journal of Mass Spectrometry 353 (November 2013): 54–59. http://dx.doi.org/10.1016/j.ijms.2013.07.004.

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13

Dalluge, Joseph J. "Matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS)." Analytical and Bioanalytical Chemistry 372, no. 1 (December 8, 2001): 18–19. http://dx.doi.org/10.1007/s00216-001-1151-4.

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14

Stults, John T. "Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS)." Current Opinion in Structural Biology 5, no. 5 (October 1995): 691–98. http://dx.doi.org/10.1016/0959-440x(95)80063-8.

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15

Fatou, Benoit, Michel Salzet, and Isabelle Fournier. "Real time human micro-organisms biotyping based on Water-Assisted Laser Desorption/Ionization." EuroBiotech Journal 3, no. 2 (April 1, 2019): 97–104. http://dx.doi.org/10.2478/ebtj-2019-0011.

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Abstract We previously demonstrated that remote infrared Matrix Assisted Laser Desorption Ionization technology (Spidermass) using endogenous water as matrix (or so called water assisted laser desorption/ionization) was enabling real-time in vitro and in vivo analysis of clinical pathological tissues. In the present work, Spidermass was used to biotype human pathogens either from liquid bacteria growth in time course, from petri dish or on smears. Reproducibility experiments as well as bacteria dispersion and lipids identifications with SpiderMass in MS/MS mode were undertaken. The whole of the data establish that SpiderMass instrument allows real time bacteria biotyping and can be useful in clinic for pathogen identification.

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16

Yang, Jing, Hongjun Zhang, Jia Jia, Xinrong Zhang, Xiaoxiao Ma, Minlin Zhong, and Zheng Ouyang. "Antireflection Surfaces for Biological Analysis Using Laser Desorption Ionization Mass Spectrometry." Research 2018 (October 31, 2018): 1–13. http://dx.doi.org/10.1155/2018/5439729.

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Laser desorption ionization mass spectrometry (LDI-MS) is a primary tool for biological analysis. Its success relies on the use of chemical matrices that facilitate soft desorption and ionization of the biomolecules, which, however, also limits its application for metabolomics study due to the chemical interference by the matrix compounds. The requirement for sample pretreatment is also undesirable for direct sampling analysis or tissue imaging. In this study, antireflection (AR) metal surfaces were investigated as sample substrates for matrix-free LDI-MS. They were prepared through ultrafast laser processing, with high light-to-heat energy conversion efficiency. The morphology and micro/nanostructures on the metal surfaces could be adjusted and optimized by tuning the laser fabrication process. The super-high UV absorption at 97% enabled highly efficient thermal desorption and ionization of analytes. The analytical performance for the matrix-free LDI was explored by analyzing a variety of biological compounds, including carbohydrates, drugs, metabolites, and amino acids. Its applicability for direct analysis of complex biological samples was also demonstrated by direct analysis of metabolites in yeast cells.

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17

Kang, Kyungtae, Hongje Jang, and Young-Kwan Kim. "The influence of polydopamine coating on gold nanorods for laser desorption/ionization time-of-flight mass spectrometric analysis." Analyst 142, no. 13 (2017): 2372–77. http://dx.doi.org/10.1039/c7an00356k.

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The influence of polydopamine (PD) coating on gold nanorods (GNRs) for laser desorption/ionization mass spectrometry (LDI-MS) analysis was systematically investigated to reveal its role in the LDI-MS analysis process.

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18

Sekuła, Justyna, Joanna Nizioł, Wojciech Rode, and Tomasz Ruman. "Silver nanostructures in laser desorption/ionization mass spectrometry and mass spectrometry imaging." Analyst 140, no. 18 (2015): 6195–209. http://dx.doi.org/10.1039/c5an00943j.

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19

Shi, C. Y., and C. H. Deng. "Recent advances in inorganic materials for LDI-MS analysis of small molecules." Analyst 141, no. 10 (2016): 2816–26. http://dx.doi.org/10.1039/c6an00220j.

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20

Kamceva, Tina, Maja Nesic, Milovan Stoiljkovic, Iva Popovic, Jadranka Miletic, Boris Rajcic, Marijana Petkovic, and Suzana Velickovic. "Determination of isotopic distribution of lead by a matrix assisted laser desorption/ionization versus a laser desorption/ionization time of flight mass spectrometry." Chemical Industry 71, no. 1 (2017): 19–26. http://dx.doi.org/10.2298/hemind151218013k.

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In this work it has been shown that both the laser desorption/ionization mass spectrometry (LDI MS) and the matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS) are the simple and quick methods for determination of relative natural isotopic distribution of lead. The analysis of metal salts with these approaches does not require any time-consuming preparation of samples: a single run can take only a minute, and numerous information can be obtained. Results obtained in this work show that chosen matrix has no negative effect on quantitative determination of lead isotopes and support once more the applicability of MALDI TOF MS for lead isotope distribution determination in the sample, and accuracy of data obtained. Additionally, the generation of PbnOn and PbnOn-1 (n: 2 - 6) clusters have been successfully achieved in the positive mode, using the both LDI and MALDI methods. All stoichiometries were confirmed using isotopic pattern modelling.

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21

Li, Yafeng, Peiqi Luo, Xiaohua Cao, Huihui Liu, Jianing Wang, Jiyun Wang, Lingpeng Zhan, and Zongxiu Nie. "Enhancing surface-assisted laser desorption ionization mass spectrometry performance by integrating plasmonic hot-electron transfer effect through surface modification." Chemical Communications 55, no. 41 (2019): 5769–72. http://dx.doi.org/10.1039/c9cc02541c.

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22

Lee, Gwangbin, Sang-Eun Bae, Seong Huh, and Sangwon Cha. "Graphene oxide embedded sol–gel (GOSG) film as a SALDI MS substrate for robust metabolite fingerprinting." RSC Advances 5, no. 70 (2015): 56455–59. http://dx.doi.org/10.1039/c5ra11497g.

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23

Weißflog, Jerrit, and Aleš Svatoš. "1,8-Di(piperidinyl)-naphthalene – rationally designed MAILD/MALDI matrix for metabolomics and imaging mass spectrometry." RSC Advances 6, no. 79 (2016): 75073–81. http://dx.doi.org/10.1039/c6ra17237g.

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24

Hua, Pei-Yang, M. Manikandan, Hani Nasser Abdelhamid, and Hui-Fen Wu. "Graphene nanoflakes as an efficient ionizing matrix for MALDI-MS based lipidomics of cancer cells and cancer stem cells." J. Mater. Chem. B 2, no. 42 (2014): 7334–43. http://dx.doi.org/10.1039/c4tb00970c.

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25

Qiu, Ran, and Hai Luo. "Reaction and detection click in high-voltage assisted laser desorption ionization mass spectrometry." Analyst 139, no. 15 (2014): 3706–8. http://dx.doi.org/10.1039/c3an02190d.

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Click by Laser@Cu in HALDI-MS: A click reaction (copper-catalyzed azide–alkyne cycloaddition) catalyzed by “naked” copper ions (without ligands) generated in situ from a copper substrate by laser ablation in a high-voltage assisted laser desorption/ionization (HALDI) ion source is demonstrated.

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26

Koudelka, Štěpán, Tereza Gelbíčová, Markéta Procházková, and Renáta Karpíšková. "Lineage and serotype identification of Listeria monocytogenes by matrix-assisted laser desorption ionization-time of flight mass spectrometry." Czech Journal of Food Sciences 36, No. 6 (January 7, 2019): 452–58. http://dx.doi.org/10.17221/87/2018-cjfs.

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The identification of Listeria species, lineages and serotypes remains a crucial issue not only in epidemic surveys, but also in monitoring of the diversity of bacteria in the food chain. The aim of this study was identification of L. monocytogenes strains at lineage and serotype level using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The performance of MALDI-TOF MS was tested to identify L. monocytogenes into two lineages (I and II) and four serotypes (1/2a, 1/2b, 1/2c and 4b) the most commonly found in humans and food. Total of 227 L. monocytogenes strains from different sources were subjected to the study. Some of strains (112) were used for main spectrum profile (MSP) library creation. Other strains of interest (115) were then correctly identified on the lineage level comparing with the library by MALDI-TOF MS analysis using Biotyper (90%) and ClinPro Tools (100%) software. The serotype identification with 55.7% (Biotyper) and 67.8% (ClinPro Tools) accuracy is rather a proof that under given conditions the method has not big potential to be used for serotyping. However, MALDI-TOF MS has a potential to identify lineages of L. monocytogenes of food and human origin.

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Fresnais, Margaux, Seda Karabulut, Yasmin Abou Zeed, Johannes Ungermann, Julia Benzel, Kristian W. Pajtler, Stefan M. Pfister, Walter E. Haefeli, Jürgen Burhenne, and Rémi Longuespée. "Important Requirements for the Selection of Internal Standards during the Development of Desorption/Ionization Assays for Drug Quantification in Biological Matrices—A Practical Example." Molecules 27, no. 3 (January 21, 2022): 690. http://dx.doi.org/10.3390/molecules27030690.

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Desorption/ionization mass spectrometry (DI-MS) approaches allow for the rapid quantification of drugs in biological matrices using assays that can be validated according to regulatory guidelines. However, specific adaptations must be applied to create reliable quantification methods, depending on the approach and instrumentation used. In the present article, we demonstrate the importance of the molecular weight, the fragmentation pattern, and the purity of the internal standard for the development of matrix-assisted laser desorption/ionization (MALDI)-ion mobility (IM)-tandem MS and MS/MS methods. We present preliminary results of method development for the quantification of selinexor in microdialysis fluids with a stable isotopically labeled internal standard. In addition, we discuss the selection of internal standards for MALDI-MS assays using different instrumentations.

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Bondarenko, A., Y. Zhu, L. Qiao, F. Cortés Salazar, H. Pick, and H. H. Girault. "Aluminium foil as a single-use substrate for MALDI-MS fingerprinting of different melanoma cell lines." Analyst 141, no. 11 (2016): 3403–10. http://dx.doi.org/10.1039/c6an00126b.

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29

Hu, Cho-Chun, Ming-Feng Huang, and Huan-Tsung Chang. "Quantitative surface-assisted laser desorption/ionization–MS approaches for bioanalysis." Bioanalysis 5, no. 6 (March 2013): 633–35. http://dx.doi.org/10.4155/bio.13.4.

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30

Haff, L. A., and I. P. Smirnov. "DNA sequence analysis by matrix-assisted laser desorption ionization MS." Biochemical Society Transactions 24, no. 3 (August 1, 1996): 901–4. http://dx.doi.org/10.1042/bst0240901.

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31

Rychert, Jenna, David Creely, Leslie M. Mayo-Smith, Stephen B. Calderwood, Louise C. Ivers, Edward T. Ryan, Jacques Boncy, et al. "Evaluation of Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Identification of Vibrio cholerae." Journal of Clinical Microbiology 53, no. 1 (November 12, 2014): 329–31. http://dx.doi.org/10.1128/jcm.02666-14.

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We evaluated the use of matrix-assisted laser desorption ionization–time of flight mass spectrometry (MS) for the identification ofVibrio cholerae. MS identified all 42 isolates ofV. choleraeO1 and O139 and 7 of 9 non-O1/O139 isolates. MS correctly discriminated between allAeromonasandV. choleraeisolates. Overall, MS performed as well as or better than biochemical methods.

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Cramer, Rainer. "High-speed Analysis of Large Sample Sets – How Can This Key Aspect of the Omics Be Achieved?" Molecular & Cellular Proteomics 19, no. 11 (August 12, 2020): 1760–66. http://dx.doi.org/10.1074/mcp.p120.001997.

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High-speed analysis of large (prote)omics sample sets at the rate of thousands or millions of samples per day on a single platform has been a challenge since the beginning of proteomics. For many years, ESI-based MS methods have dominated proteomics because of their high sensitivity and great depth in analyzing complex proteomes. However, despite improvements in speed, ESI-based MS methods are fundamentally limited by their sample introduction, which excludes off-line sample preparation/fractionation because of the time required to switch between individual samples/sample fractions, and therefore being dependent on the speed of on-line sample preparation methods such as liquid chromatography. Laser-based ionization methods have the advantage of moving from one sample to the next without these limitations, being mainly restricted by the speed of modern sample stages, i.e. 10 ms or less between samples. This speed matches the data acquisition speed of modern high-performing mass spectrometers whereas the pulse repetition rate of the lasers (>1 kHz) provides a sufficient number of desorption/ionization events for successful ion signal detection from each sample at the above speed of the sample stages. Other advantages of laser-based ionization methods include the generally higher tolerance to sample additives and contamination compared with ESI MS, and the contact-less and pulsed nature of the laser used for desorption, reducing the risk of cross-contamination. Furthermore, new developments in MALDI have expanded its analytical capabilities, now being able to fully exploit high-performing hybrid mass analyzers and their strengths in sensitivity and MS/MS analysis by generating an ESI-like stable yield of multiply charged analyte ions. Thus, these new developments and the intrinsically high speed of laser-based methods now provide a good basis for tackling extreme sample analysis speed in the omics.

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Emanuelson, Cole, Nicholas Ankenbruck, Alexander Deiters, and Marvin S. Yu. "High-Throughput Amenable MALDI-MS Detection of RNA and DNA with On-Surface Analyte Enrichment Using Fluorous Partitioning." SLAS DISCOVERY: Advancing the Science of Drug Discovery 26, no. 1 (September 29, 2020): 58–66. http://dx.doi.org/10.1177/2472555220958391.

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High-throughput matrix-assisted laser desorption/ionization mass spectrometry (HT-MALDI-MS) has garnered considerable attention within the drug discovery industry as an information-rich alternative to assays using light-based detection methods. To date, these efforts have been primarily focused on assays using protein or peptide substrates. Methods for RNA or DNA analysis by HT-MALDI-MS have not been extensively reported due to the challenges associated with MALDI-MS of oligonucleotides, including the propensity to form multiple salt adducts, low ionization potential, and ease of fragmentation. The objective of this work was to develop a platform suitable for HT-MS analysis of RNA and DNA substrates that overcomes these hurdles by combining on-surface sample preparation with soft ionization. This has been accomplished through the selective immobilization of fluorous-tagged oligonucleotides on a fluorous-modified MS target plate, followed by on-surface enrichment, matrix addition, and direct laser desorption/ionization, a process dubbed fluorous HT-MS (F-HT-MS). The work has resulted in methods by which RNA and DNA substrates can be detected at nanomolar concentrations from a typical assay buffer system using procedures that are amenable to full automation. The protocols were applied to an miRNA biogenesis assay, demonstrating its potential for RNA processes and thereby filling a prominent gap in RNA drug discovery: the paucity of in vitro functional assays.

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Compton, Bruce Jon, and Gary Siuzdak. "Mass spectrometry in nucleic acid, carbohydrate and steroid analysis." Spectroscopy 17, no. 4 (2003): 699–713. http://dx.doi.org/10.1155/2003/725480.

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Mass spectrometry is now widely used in many areas of biomolecule analysis and this diversity is well represented by the analysis of oligonucleotides, carbohydrates and steroids. In this paper an overview of the common techniques used for analysis of these biomolecules is presented, including electrospray ionization (ESI), matrix-assisted laser desorption/ionization (MALDI), desorption/ionization on silicon (DIOS), and negative chemical ionization gas chromatography mass spectrometry (NCI GC/MS). Additionally, important aspects of biomolecule analysis, such as molecular weight determination, sequencing using tandem mass spectrometry and enzymes, precursor ion scanning, noncovalent interactions, and sensitivity, will be discussed.

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35

Wang, Xiaodong, Jun Han, Juncong Yang, Jingxi Pan, and Christoph H. Borchers. "Matrix coating assisted by an electric field (MCAEF) for enhanced tissue imaging by MALDI-MS." Chemical Science 6, no. 1 (2015): 729–38. http://dx.doi.org/10.1039/c4sc01850h.

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A novel technique, termed matrix coating assisted by an electric field (MCAEF) for enhancing tissue imaging by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) was developed in this study.

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36

Liu, Ping, Yongjun Hu, Guichi Zhu, Qing Yang, and Yanmin Tao. "Direct and fast detection of chlorothalonil in soil samples using laser desorption VUV single photon post-ionization mass spectrometry." Analytical Methods 7, no. 16 (2015): 6890–95. http://dx.doi.org/10.1039/c5ay01097g.

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37

Guinan, T. M., P. Kirkbride, C. B. Della Vedova, S. G. Kershaw, H. Kobus, and N. H. Voelcker. "Direct detection of illicit drugs from biological fluids by desorption/ionization mass spectrometry with nanoporous silicon microparticles." Analyst 140, no. 23 (2015): 7926–33. http://dx.doi.org/10.1039/c5an01754h.

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Surface assisted laser desorption/ionization mass spectrometry (SALDI-MS) with porous silicon microparticles was used for the all-in-one extraction and detection of illicit drugs from saliva, urine and plasma.

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38

Song, Kyuseok, and Quan Cheng. "Desorption and ionization mechanisms and signal enhancement in surface assisted laser desorption ionization mass spectrometry (SALDI-MS)." Applied Spectroscopy Reviews 55, no. 3 (February 26, 2019): 220–42. http://dx.doi.org/10.1080/05704928.2019.1570519.

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39

Liu, Guo Yong, Xiao Tao Shi, Zhi Ying Tu, Li Ming Liu, and Ying Ping Huang. "Proteomic Analysis of Gill Mucus from Grass Carp Ctenopharyngodon idella." Advanced Materials Research 718-720 (July 2013): 288–92. http://dx.doi.org/10.4028/www.scientific.net/amr.718-720.288.

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Fish gills is part of the first-line defense in fish. The proteome in gill mucus of grass carp (Ctenopharyngodon idella) was examined in this study. Two-dimensional polyacrylamide gel electrophoresis, in combination with size exclusion chromatography, was used to resolve the proteins. Two-dimensional maps of gill mucus revealed 406 distinct spots with Coomassie blue staining, of which 256 protein spots were subjected to identification using matrix-assisted laser desorption / ionization time-of-flight (MALDI-TOF), matrix-assisted laser desorption / ionization tandem mass spectrometry (MALDI-MS / MS) and liquid chromatography tandem mass spectrometry (LC-MS / MS). A total of 99 spots representing 52 proteins were identified, including 19 immune-related molecules such as lectin, interlectin, transferrin, and proteasome. Their presence in gill mucus may imply the importance of non-specific immunity in gill mucus. The present study provides the first picture on proteome in mucus of a fish species, and thus the foundation for understanding quantitative and qualitative variation in proteins in the mucus.

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Abdelhamid, Hani Nasser, Yu Chih Lin, and Hui-Fen Wu. "Magnetic nanoparticle modified chitosan for surface enhanced laser desorption/ionization mass spectrometry of surfactants." RSC Advances 7, no. 66 (2017): 41585–92. http://dx.doi.org/10.1039/c7ra05982e.

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Chitosan (CTS) modified magnetic nanoparticles (CTS@Fe₃O₄MNPs) offer dual functions for the detection of surfactants using surface enhanced laser desorption/ionization mass spectrometry (SELDI-MS).

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van Eck, Kim, Dirk Faro, Melanie Wattenberg, Arjan de Jong, Saskia Kuipers, and Jakko van Ingen. "Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Fails To Identify Nontuberculous Mycobacteria from Primary Cultures of Respiratory Samples: TABLE 1." Journal of Clinical Microbiology 54, no. 7 (May 4, 2016): 1915–17. http://dx.doi.org/10.1128/jcm.00304-16.

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We have assessed matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) identification (Bruker) of nontuberculous mycobacteria from newly positive liquid cultures of respiratory samples. Twelve (22%) of 54 isolates were identified directly from liquid medium. After subculture and with manual laser operation, this rose to 49/54 isolates (91%). MALDI-TOF MS is less promising than previously suggested.

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Tsuchida, Sachio, and Tomohiro Nakayama. "MALDI-Based Mass Spectrometry in Clinical Testing: Focus on Bacterial Identification." Applied Sciences 12, no. 6 (March 9, 2022): 2814. http://dx.doi.org/10.3390/app12062814.

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The term “proteome” refers to the total of all proteins expressed in an organism. The term “proteomics” refers to the field of research that includes not only information on the expression levels of individual proteins, but also their higher-order structures, intermolecular interactions, and post-translational modifications. The core technology, matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), is available for protein analysis thanks to the work of Koichi Tanaka and John Fenn, who were awarded the Nobel Prize in Chemistry in 2002. The most successful proteome analysis in clinical practice is rapid microbial identification. This method determines the bacterial species by comparing the proteome profile of the bacteria obtained by matrix-assisted laser desorption ionization-time of flight MS (MALDI-TOF MS) with a database. MS is superior in simplicity, speed, and accuracy to classic speciation by staining and phenotyping. In clinical microbiology, MS has had a large impact on the diagnosis and treatment of infectious disease. Early diagnosis and treatment of infectious disease are important, and rapid identification by MALDI-TOF MS has made a major contribution to this field.

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DeLaney, Kellen, and Lingjun Li. "Capillary electrophoresis coupled to MALDI mass spectrometry imaging with large volume sample stacking injection for improved coverage of C. borealis neuropeptidome." Analyst 145, no. 1 (2020): 61–69. http://dx.doi.org/10.1039/c9an01883b.

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This work reports on a capillary electrophoresis (CE) separation method coupled to matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) imaging for improved neuropeptide coverage in the model organism Cancer borealis.

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Wu, Ching-Yi, Kai-Chieh Lee, Yen-Ling Kuo, and Yu-Chie Chen. "Revisiting the quantitative features of surface-assisted laser desorption/ionization mass spectrometric analysis." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, no. 2079 (October 28, 2016): 20150379. http://dx.doi.org/10.1098/rsta.2015.0379.

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Surface-assisted laser desorption/ionization (SALDI) coupled with mass spectrometry (MS) is frequently used to analyse small organics owing to its clean background. Inorganic materials can be used as energy absorbers and the transfer medium to facilitate the desorption/ionization of analytes; thus, they are used as SALDI-assisting materials. Many studies have demonstrated the usefulness of SALDI-MS in quantitative analysis of small organics. However, some characteristics occurring in SALDI-MS require certain attention to ensure the reliability of the quantitative analysis results. The appearance of a coffee-ring effect in SALDI sample preparation is the primary factor that can affect quantitative SALDI-MS analysis results. However, to the best of our knowledge, there are no reports relating to quantitative SALDI-MS analysis that discuss or consider this effect. In this study, the coffee-ring effect is discussed using nanoparticles and nanostructured substrates as SALDI-assisting materials to show how this effect influences SALDI-MS analysis results. Potential solutions for overcoming the existing problems are also suggested. This article is part of the themed issue ‘Quantitative mass spectrometry’.

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Silina, Yuliya E., Claudia Fink-Straube, Heiko Hayen, and Dietrich A. Volmer. "Analysis of fatty acids and triacylglycerides by Pd nanoparticle-assisted laser desorption/ionization mass spectrometry." Analytical Methods 7, no. 9 (2015): 3701–7. http://dx.doi.org/10.1039/c5ay00705d.

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In this study, we propose a simple and rapid technique for characterization of free fatty acids and triacylglycerides (TAG) based on palladium nanoparticular (Pd-NP) surface-assisted laser desorption/ionization (SALDI) mass spectrometry (MS).

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Yoo, Hee-Jin, Duck-Hyun Kim, DongJin Shin, YoonSeok Oh, SungJun Lee, Jae Yong Lee, Yoon-Ji Choi, et al. "Recent developments in pre-treatment and analytical techniques for synthetic polymers by MALDI-TOF mass spectrometry." Analytical Methods 12, no. 48 (2020): 5767–800. http://dx.doi.org/10.1039/d0ay01729a.

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A great deal of effort has been expended to develop accurate means of determining the properties of synthetic polymers using matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS).

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Ouyang, Dan, Kailong Luo, Wende Ma, Jie Wu, Jing Li, Yanting He, Zongwei Cai, and Zian Lin. "A spherical covalent-organic framework for enhancing laser desorption/ionization mass spectrometry for small molecule detection." Analyst 145, no. 8 (2020): 3125–30. http://dx.doi.org/10.1039/d0an00171f.

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A spherical vinyl-functionalized covalent-organic framework (COF-V) was prepared at room temperature by a facile method and applied as a novel substrate for surface-enhanced laser desorption/ionization mass spectrometry (SELDI-MS).

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Hong, Yu Lim, Jieon Lee, Bon-Cheol Ku, Kyungtae Kang, Seunghyun Lee, Seongwoo Ryu, and Young-Kwan Kim. "The influence of oxidative debris on the fragmentation and laser desorption/ionization process of graphene oxide derivatives." New Journal of Chemistry 42, no. 15 (2018): 12692–97. http://dx.doi.org/10.1039/c8nj02628a.

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The influence of oxidative debris on laser desorption/ionization time of flight mass spectrometry (LDI-TOF-MS) analysis by using graphene oxide as a matrix was investigated to reveal its role in LDI process.

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Ye, Neng Sheng, Ya Li Xie, Chang Liu, and Jian Li. "Enrichment of Peptide with Graphene for MALDI-TOF MS Analysis." Advanced Materials Research 781-784 (September 2013): 111–14. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.111.

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In this paper, graphene was used as the adsorbent for peptide enrichment, and followed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis. To study the adsorptive property of graphene, peptide angiotensin II was chosen as the model target. The enrichment material was analyzed by MALDI-TOF MS directly without desorption step. As a result, graphene showed good adsorptive capacity for peptide. After enrichment, the peak intensity and the signal-to-noise ratio were obviously increased.

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Yaman, Mehmet Emrah, Haci Mehmet Kayili, Mevlut Albayrak, Yucel Kadioglu, and Bekir Salih. "Differential N-glycosylation profiling of formalin-fixed paraffin-embedded (FFPE) invasive ductal carcinoma tissues using MALDI-TOF-MS." Molecular Omics 17, no. 3 (2021): 394–404. http://dx.doi.org/10.1039/d0mo00150c.

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Invasive ductal carcinoma (IDC) is the most common type of breast cancer. In this study, matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS)-based analyses were conducted for determining differential N-glycosylation patterns of IDC.

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