Relevant bibliographies by topics / Laser desorption ionization MS

Academic literature on the topic 'Laser desorption ionization MS'

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Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Laser desorption ionization MS"

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Castellanos-Garcia, Laura J., Kristen N. Sikora, Jeerapat Doungchawee, and Richard W. Vachet. "LA-ICP-MS and MALDI-MS image registration for correlating nanomaterial biodistributions and their biochemical effects." Analyst 146, no. 24 (2021): 7720–29. http://dx.doi.org/10.1039/d1an01783g.

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Laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) imaging and matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) can measure distributions of elements and biomolecules in tissue sections.
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Tata, Alessandra, Anna Maria A. P. Fernandes, Vanessa G. Santos, Rosana M. Alberici, Dioneia Araldi, Carlos A. Parada, Wellington Braguini, et al. "Nanoassisted Laser Desorption-Ionization-MS Imaging of Tumors." Analytical Chemistry 84, no. 15 (July 16, 2012): 6341–45. http://dx.doi.org/10.1021/ac301202q.

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Sholokhova, Anastasiya Yu, Svetlana A. Borovikova, Sergey A. Prikhod'ko, and Alexey K. Buryak. "Ionization of ionic liquids under laser desorption/ionization." Сорбционные и хроматографические процессы 20, no. 5 (November 25, 2020): 565–71. http://dx.doi.org/10.17308/sorpchrom.2020.20/3048.

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Despite various studies of ILs as MALDI matrices, however, so far no relationship has been foundbetween the composition of ILs and their ability to serve as «good» matrices. For a preliminary experiment,in order to evaluate the characteristics of ILs before being used as a matrix in MALDI-MS, it is necessary tostudy the mass spectral behavior for the matrices themselves under LDI conditions. Therefore, the purpose of this work was to analyse ion liquids based on the cation imidazolium in combination with different types ofanions by the LDI method. Ionic liquids were synthesized in the Laboratory of catalytic processes for thesynthesis of organoelement compounds of G.K. Boreskov Institute of catalysis SB RAS (Novosibirsk). Itshould be noted that this ionic liquid was first synthesized in this Laboratory. Analyses were performed usinga Bruker UltraFlex II time of-flight mass spectrometer. Eleven ion liquids based on substituted cation imidazolium in combination with different types of anions were analysed by method laser desorption/ionization in the paper. In all mass spectra of ionic liquids obtained in the positive ion mode, cation produced a major peak and its fragmented ions. Homologous series characterized by the loss of the methyl group have been recorded. According to the more stable carbon-carbon or nitrogen bond in the heterocyclic system than in the carbon-carbon bond in the aliphatic, ion peaks are observed in the mass spectra, characteristic of the loss of methyl fragments from the aliphatic chain. In the LDI spectra obtained in the negative ion mode, the signals of the anions of ionic liquids and their fragments were observed. The combined use of the spectra obtained in positive and negative mode makes it possible to increase the reliability of identification. This makes it possible to use the revealed patterns of fragmentation for the structural analysis of ionic liquids. The analyzed ILs can be used as MALDI matrices, because they do not form dimers, assassinates, are characterized by the absence of adducts with metal ions, which is important for their further use as matrices. BMIMC6F5BF3 was first described by the LDI-MS method. It was shown that the observed fragmentation of the molecular ion of this IL is typical for most ILs with similar cations.
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Vidová, Veronika, Michael Volný, Karel Lemr, and Vladimír Havlíček. "Surface analysis by imaging mass spectrometry." Collection of Czechoslovak Chemical Communications 74, no. 7-8 (2009): 1101–16. http://dx.doi.org/10.1135/cccc2009028.

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A review of four MS-based techniques available for molecular surface imaging is presented. The main focus is on the commercially available mass spectrometry imaging techniques: secondary ion mass spectrometry (SIMS), matrix assisted laser desorption ionization mass spectrometry (MALDI-MS), desorption electrospray ionization mass spectrometry (DESI-MS) and laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS). A short historical perspective is presented and traditional desorption ionization techniques are also briefly described. The four techniques are compared mainly with respect to their usage for imaging of biological surfaces. MALDI is evaluated as the most successful in life sciences and the only technique usable for imaging of large biopolymers. SIMS is less common but offers superior spatial lateral resolution and DESI is considered to be an emerging alternative approach in mass spectrometry imaging. LA-ICP ionization is unbeatable in terms of limits of detection but does not provide structural information. All techniques are considered extremely useful, representing a new wave of expansion of mass spectrometry into surface science and bioanalysis. A minireview with 121 references.
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Santos, Inês C., Zacariah L. Hildenbrand, and Kevin A. Schug. "Applications of MALDI-TOF MS in environmental microbiology." Analyst 141, no. 10 (2016): 2827–37. http://dx.doi.org/10.1039/c6an00131a.

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Prysiazhnyi, Vadym, Filip Dycka, Jiri Kratochvil, Vitezslav Stranak, and Vladimir N. Popok. "Effect of Ag Nanoparticle Size on Ion Formation in Nanoparticle Assisted LDI MS." Applied Nano 1, no. 1 (August 24, 2020): 3–13. http://dx.doi.org/10.3390/applnano1010002.

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Metal nanoparticles (NPs) were reported as an efficient matrix for detection of small molecules using laser desorption/ionization mass spectrometry. Their pronounced efficiency is mostly in desorption enhancement, while, in some cases, NPs can facilitate charge transfer to a molecule, which has been reported for alkali metals and silver. In this work, we present the study of the influence of Ag NP size on the laser desorption/ionization mass spectra of a model analyte, the molecule of riboflavin. The NPs were produced by magnetron sputtering-based gas aggregation in a vacuum and mass-filtered before the deposition on substrates. It was found that the utilization of smaller Ag NPs (below 15 nm in diameter) considerably enhanced the molecule desorption. In contrast, the laser irradiation of the samples with larger NPs led to the increased ablation of silver, resulting in [analyte + Ag]+ adduct formation.
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Ali, Arslan, Najia Shahid, and Syed Ghulam Musharraf. "Application of dyes as doping agents in MALDI-MS matrices for the signal enhancement of proteins." RSC Advances 7, no. 11 (2017): 6598–604. http://dx.doi.org/10.1039/c6ra27156a.

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Wang, Chia-Chen, Yin-Hung Lai, Yu-Meng Ou, Huan-Tsung Chang, and Yi-Sheng Wang. "Critical factors determining the quantification capability of matrix-assisted laser desorption/ionization– time-of-flight mass spectrometry." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, no. 2079 (October 28, 2016): 20150371. http://dx.doi.org/10.1098/rsta.2015.0371.

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Quantitative analysis with mass spectrometry (MS) is important but challenging. Matrix-assisted laser desorption/ionization (MALDI) coupled with time-of-flight (TOF) MS offers superior sensitivity, resolution and speed, but such techniques have numerous disadvantages that hinder quantitative analyses. This review summarizes essential obstacles to analyte quantification with MALDI-TOF MS, including the complex ionization mechanism of MALDI, sensitive characteristics of the applied electric fields and the mass-dependent detection efficiency of ion detectors. General quantitative ionization and desorption interpretations of ion production are described. Important instrument parameters and available methods of MALDI-TOF MS used for quantitative analysis are also reviewed. This article is part of the themed issue ‘Quantitative mass spectrometry’.
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Morris, Nicholas J., Heather Anderson, Brian Thibeault, Akos Vertes, Matthew J. Powell, and Trust T. Razunguzwa. "Laser desorption ionization (LDI) silicon nanopost array chips fabricated using deep UV projection lithography and deep reactive ion etching." RSC Advances 5, no. 88 (2015): 72051–57. http://dx.doi.org/10.1039/c5ra11875a.

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Dong, Jinlan, Wenjing Ning, Daniel J. Mans, and Jamie D. Mans. "A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS." Analytical Methods 10, no. 6 (2018): 572–78. http://dx.doi.org/10.1039/c7ay02583a.

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A mixture of α-cyano-4-hydroxycinnamic acid and 1,5-diaminonaphthalene was discovered as a novel binary matrix for the qualitative analysis of 14 small-molecule (∼250–550 Da) cardiovascular drugs by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and MS/MS in either positive or negative ion mode.
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Dissertations / Theses on the topic "Laser desorption ionization MS"

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Tummala, Manorama. "Surfactant-Aided Matrix Assisted Laser Desorption/Ionization Mass Spectrometry (SA-MALDI MS)." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100672049.

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Sorensen, Christina M. "ESI-MS and MALDI-TOF-MS for the characterization and analysis of metallo-oligomers and proteins." Laramie, Wyo. : University of Wyoming, 2005. http://proquest.umi.com/pqdweb?did=1031044031&sid=4&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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Segu, Mohideen Mohamed Zaneer. "TARGET MODIFICATION FOR ENHANCED PERFORMANCE MATRIX ASSISTED LASER DESORPTION IONIZATION (MALDI) MASS SPECTROMETRY." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1674093101&sid=1&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Thesis (Ph. D.)--Southern Illinois University Carbondale, 2008.
"Department of Chemistry." Keywords: Enhanced MALDI, MALDI-MS, On-probe separation, Protein-surface interactions, Sublayers, Surface binding capacity. Includes bibliographical references (p. 130-148). Also available online.
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Ratcliffe, Lucy Vivien. "Proteomic strategies for protein and biomarker identification by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS)." Thesis, Nottingham Trent University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431885.

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This thesis describes the development of novel strategies for the analysis of peptides by MALDI mass spectrometry. The developed techniques are applied to the identification of protein and proteomic biomarkers for melanoma. A commercial atmospheric pressure (APMALDI) source (MassTechnologies, Burtonsville, MD, USA) was modified to allow operation with a high powered nitrogen laser and independent PC control of the sample stage. A software interface was developed using LabVIEW 6.1 that allows full control of the target position with respect to the laser fibre optic interface, allowing the target to be adjusted within any point within a particular sample spot to enhance signal quality. The modified AP-MALDI-QIT interface was evaluated for the analysis of standard peptide mixtures and tryptic digests of proteins. AP-MALDI-QIT analysis of tryptic peptides following capillary liquid chromatographic (LC) separation and direct analysis of a protein digest is reported. Peptide fragments were identified by peptide mass fingerprinting from mass spectrometric data and sequence analysis obtained by tandem mass spectrometry of the principal mass spectral peaks using a data-dependent scanning protocol. These data were compared with those from mass spectrometric analysis using capillary LC/MALDI-time-of-flight (TOF) and capillary LC/electrospray ionisation (ESI)-quadrupole TOF. For all three configurations the resulting data were searched against the MSDB database, using MASCOT and the sequence coverage compared for each technique. Complementary data were obtained using the three techniques. A bottom-up proteomic methodology for the peptide profiling of human serum samples using MALDI mass spectrometry was developed. Reproducibility studies were carried out to define the MALDI measurement precision. Pre-analytical sample handling factors, such as room temperature incubation and freeze thaw cycles have also been investigated. The methodology developed was applied to the analysis of serum peptides from stage IV melanoma patients and healthy control subjects. Prediction of human melanoma metastatic cancer from peptide profiling using artificial neural networks (ANNs) model classified 98 % of samples correctly. The identification of three out of six ions predicted by the ANNs model to be indicative biomarkers that have good predictive performance were identified using MALDI PSD, AP-MALDI MSIMS and LC-ESI-MS/MS. Two of the ions were shown to belong to the same identified peptide, u-l-acid glycoprotein precursor (l, 2) which correctly predicted 95 % (i.e. 45/50) of metastatic melanoma patients.
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PENG, LIJUAN. "MATRIX-ASSISTED LASER DESORPTION/IONIZATION (MALDI) TARGET MODIFICATION FOR ENHANCED PROTEOMICS ANALYSIS AND PLASMA POLYMER CHARACTERIZATION BY MALDI MASS SPECTROMETRY." OpenSIUC, 2010. https://opensiuc.lib.siu.edu/dissertations/207.

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The work described in this dissertation is divided into three sections. In the first section three surface modifications are used to produce MALDI targets having reduced surface-protein binding affinity with a goal of increasing peptide/protein MALDI ion signals and lowering the limits of detection (LODs) for proteins and peptides. The second section discusses a bioselective MALDI target, produced via radio frequency (rf) plasma deposited ethylenediamine (EDA), for on-target separation of complex protein mixtures. The third section develops a new approach for characterization of rf plasma-deposited bulk polymers by using MALDI MS. Previous studies in our group have shown that the analyte signal in a MALDI MS experiment is strongly influenced by the binding interactions between the target surface and the analyte. Specifically, the analyte signal increases with decreasing surface-analyte binding affinity, which has been attributed to more unbound analyte being available for incorporation within the MALDI matrix. In the presented studies MALDI targets are modified with polyethylene glycol (PEG)-like structures via chemical grafting of PEG onto polyurethane (PU) film and rf plasma polymerization of ethylene oxide vinyl ether (EO2) and tetraglyme. It is shown that there are enhancements in the protein MALDI ion signals on these modified targets and that the LOD for target proteins is decreased by a factor of 2-10 in comparison with the conventional stainless steel MALDI target. On-probe affinity capture (OPAC) MALDI MS, developed in our group, has shown that functional group modified MALDI targets can be used to rapidly and selectively isolate target analytes from complex samples. For applications involving analysis of complex peptide/protein mixtures, fractionation of the mixture on the basis of component pI can reduce MALDI ion suppression effects leading to efficient ionization of larger numbers of mixture components. In the present studies a MALDI target is modified by rf plasma deposition of polymerized EDA to yield an OPAC target suitable for capture of proteins with low pI (expected to be negatively charged at neutral pH). In subsequent MALDI MS analyses of both control and biological mixtures after fractionation on the OPAC target it is observed that a significant number of additional peptide/protein ion signals are detected. The results of these studies, along with studies of the effects of the density of the primary amine functionality on the bio-selective MALDI ion signals, are presented. The complex nature of the polymer films resulting from plasma polymerization makes it very difficult to characterize their molecular structures. The presented study is the first to use MALDI MS for characterization of rf plasma-deposited bulk polymers and for investigation of the rf plasma polymerization process. It is shown that the mass spectra of the soluble fraction of allyl alcohol, EO2 and ethylene glycol butyl vinyl ether -plasma polymers contain clear polymer series. Furthermore, it is found that the peaks of the EO2-plasma polymer series shift to higher molecular weight distribution with decreasing plasma duty cycle. In contrast to predictions based on conventional radical polymerization, the mass spectra of all three plasma polymers exhibit the same repeat unit of 44 Da, for which the most likely structure would be -(CH2CH2O)-.
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Yao, Mengmeng. "Determining Polymer Blend Surface Concentration Using Surface Layer Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (SL-MALDI-TOF MS)." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1407941345.

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Hill, Jacob A. Hill. "SURFACE LAYER MATRIX-ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY (SL-MALDI-TOF MS) ANALYSIS OF POLYMER BLEND SURFACE COMPOSITION." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1514479406062149.

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Thenstedt, Niklas. "Detektion av hydrolyserad β-laktamantibiotika i plasma med Matrix-Assisted Laser Desorption Ionization – Time of Flight Mass Spectrometry och Liquid Chromatography tandem Mass Spectrometry." Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84594.

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Introduktion Antibiotikaresistens är ett globalt växande problem. Till gruppen β-laktamantibiotika hör piperacillin-tazobaktam och cefotaxim som båda verkar genom att försvaga cellväggen med kovalenta bindningar till peptidoglykanlagret som lyserar cellen. E. coli och K. pneumoniae tillhör gruppen Enterobacteriaceae, som är en del av den humana tarmfloran och ofta förekommande vid urinvägsinfektion och sepsis. Utvidgat Spektrum β-Laktamas (ESBL) är ett enzym som finns hos Enterobacteriaceae och som hydrolyserar β-laktamantibiotika. Matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) är en kvalitativ analysteknik för detektion av kemiska föreningar i avseende på massa och laddning. Kännedom om antibiotikametaboliters molekylvikt vid hydrolys möjliggör detektion. Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) är en högsensitiv kvantifieringsmetod som separerar molekyler i avseende på polaritet för vidare detektion i avseende på massa och laddning. Syfte Syftet med denna studie var att vidareutveckla en snabb och effektiv metod för att påvisa nedbrytning av piperacillin-tazobaktam och cefotaxim i blodplasma med LC-MS/MS. Material och Metod Tiofaldigt sjunkande koncentrationer av piperacillin-tazobaktam från 2000 till 2 µg/ml, och cefotaxim med koncentrationerna 500 till 0,5 µg/ml analyserades med MALDI-TOF MS, dels intakt men även med bakterierna E. coli och K. pneumoniae med uttryck av olika resistensmekanismer. Vid optimerade koncentrationer spikades plasmaprover med nedbrutet antibiotika som sedan kvantifierades med LC-MS/MS. Resultat Lägsta detektionsgräns med MALDI-TOF MS för intakt och hydrolyserat piperacillin-tazobaktam var 20/2,5 µg/ml. För cefotaxim var lägsta gränsen 5 µg/ml. Med kliniskt relevanta blodkoncentrationer gick hydrolys inte att detektera för. Med tre bakteriekolonier/50 µl kunde dock hydrolys detekteras och kvantifieras med LC-MS/MS. Slutsats Detektion av β-laktamantibiotika är möjligt med både MALDI-TOF MS och LC-MS/MS. För att påvisa hydrolys krävdes större mängder bakterier än förväntat med LC-MS/MS.
Introduction Antibiotic resistance is a global growing problem. Piperacillin-tazobactam and cefotaxime are parts of the group β-lactam antibiotics. The common feature is to inhibit the cell wall synthesis by covalent bindings to the peptidoglycan layer and thereby causing lysis of the bacterial cell. E. coli and K. pneumoniae are members of the Enterobacteriaceae which is a part of the human normal flora but also are commonly associated with urinary tract infections which sometimes develops into to sepsis. Extended Spectrum β-Lactamases (ESBLs) are enzymes with hydrolytic abilities acting on β-lactam antibiotics, expressed by Enterobacteriaceae. The qualitative, Matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) can be used to detect chemical compounds in the ratio of mass to charge in accordance to their molecular weight. Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) is a highly sensitive two-step method of quantification which first separate molecules by their polarity attraction force and then by the ratio of mass to charge. Aim The aim of this study was to develop a fast and efficient method to determine degradation of piperacillin-tazobactam and cefotaxime in blood plasma by LC-MS/MS. Method Tenfold dilution of piperacillin-tazobactam in concentrations of 2000 to 2 µg/ml, and cefotaxime in concentrations of 500 to 0,5 µg/ml where analyzed by MALDI-TOF MS, intact and also with the bacteria E. coli and K. pneumoniae with different expression of antibiotic resistance. Optimized concentrations where fixed in blood plasma and then quantified by LC-MS/MS. Result The detection limit by using MALDI TOF MS of hydrolyzed as well as non-hydrolyzed piperacillin-tazobactam was 20/2,5 µg/ml. The detection limit in cefotaxime was 5 µg/ml. Hydrolysis could not be detected in clinically fixed blood concentrations. Detection and quantification of hydrolysis by LC-MS/MS was possible in a concentration of three bacteria colonies/50 µl. Conclusion It is possible to detect hydrolysis in both MALDI TOF MS and LC-MS/MS. A larger amount of bacteria than expected was needed to demonstrate hydrolysis In LC-MS/MS.
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Huang, Huan. "Optimizing Deposition of Matrix and Ionization Salt via Two-Step Sublimation in Sample Preparation for Surface-Layer Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging (SL-MALDI-TOF MSI)." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1619183035472425.

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Guerreiro, Tatiane Melina 1987. "Análise de marcadores químicos de adulteração de vinagre balsâmico por 'silica plate laser desorption/ionization mass spectrometry' (SP-LDI-MS)." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313028.

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Orientador: Rodrigo Ramos Catharino
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-26T18:57:06Z (GMT). No. of bitstreams: 1 Guerreiro_TatianeMelina_M.pdf: 2016380 bytes, checksum: ef19a1e7b43ddd65fdb309939a8ceaf1 (MD5) Previous issue date: 2015
Resumo: O Vinagre Balsâmico é um produto italiano de grande valor, bastante apreciado em todo o mundo devido ao seu sabor característico e aos seus potenciais benefícios à saúde. Ao longo dos últimos anos, diversos pesquisadores realizaram estudos que avaliaram a sua composição físico-química, microbiana e suas propriedades benéficas. Devido ao alto número de estudos que confirmam o seu caráter antioxidante e suas propriedades anti-hipertensivas e antiglicêmicas, o vinagre balsâmico é um produto alvo de fraudes e adulterações. Desta forma, há uma preocupação acerca dos balsâmicos autênticos, que possuam certificação tanto para sua origem (região ou país), como para suas condições de processamento, garantindo sua qualidade e originalidade. Por isso, o esforço para a redução de fraudes, bem como a garantia da qualidade dos balsâmicos são de grande interesse tanto para saúde do consumidor, quanto do ponto de vista econômico. Buscando encontrar estratégias analíticas confiáveis, capazes de avaliar rapidamente a qualidade do vinagre balsâmico, este trabalho emprega a técnica de Espectrometria de Massas por Ionização/Dessorção a Laser em Placa de Sílica (SP-LDI-MS) para a rápida caracterização química de amostras de vinagres balsâmicos comercial e com indicação geográfica protegida (IGP), e identificação de suas amostras adulteradas com vinagres de baixo custo, provenientes de maçã, álcool e vinhos branco e tinto
Abstract: The Balsamic Vinegar is a valuable Italian product, very popular worldwide due to its distinctive flavor and potential health benefits. Several studies have been conducted to assess physicochemical and microbial compositions as well as with respect to its beneficial properties. Due to the high number of studies that confirm its antioxidant character and their antihypertensive and antiglycemic properties, balsamic vinegar is a potential target for frauds and adulterations. Thus, there is growing concern about the search for authenticated balsamics, so make sure your origin (region or country) as well as their processing conditions, which guarantee quality and originality of balsamic vinegar. Striving for fraud reduction and ensuring the quality and safety of food through reliable analytical strategies to quickly assess the quality of balsamic vinegar are of great interest to health and the economic point of view. In this context, this work employs the technique of Silica Plate Laser Desorption/Ionization Mass Spectrometry (SP-LDI-MS) for rapid chemical characterization of samples of commercial balsamic vinegars and with protected geographical indications (PGI) and identification their samples adulterated with inexpensive vinegars from apple, alcohol and red and white wines
Mestrado
Fisiopatologia Médica
Mestra em Ciências
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Books on the topic "Laser desorption ionization MS"

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Rogers, Kevin Shaun. Laser desorption/laser ionization mass spectrometry. Salford: University of Salford, 1993.

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Lu, Tian. Nanomaterials for Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-07749-9.

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Kopecký, Dušan. Deposition of polypyrrole thin films by advanced method: Matrix assisted pulsed laser evaporation. Hauppauge, N.Y: Nova Science Publishers, 2011.

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Peptidomics: Methods and protocols. New York, NY: Humana Press, 2010.

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Lu, Tian. Nanomaterials for Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry. Springer, 2015.

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Lu, Tian. Nanomaterials for Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry. Springer International Publishing AG, 2016.

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Lu, Tian. Nanomaterials for Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry. Springer, 2015.

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Vargas, Rafael Roberto. Development of laser desorption ionization on a quadrupole ion trap mass spectrometer. 1993.

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Vargas, Rafael. Development of Laser Desorption Ionization on a Quadrupole Ion Trap Mass Spectrometer. Creative Media Partners, LLC, 2019.

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Vargas, Rafael. Development of Laser Desorption Ionization on a Quadrupole Ion Trap Mass Spectrometer. Creative Media Partners, LLC, 2019.

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Book chapters on the topic "Laser desorption ionization MS"

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Santos, Cledir, Paula Galeano, Reginaldo Lima Neto, Manoel Marques Evangelista Oliveira, and Nelson Lima. "MALDI-TOF MS and its requirements for fungal identification." In Trends in the systematics of bacteria and fungi, 119–40. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789244984.0119.

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Abstract Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) is now used as a routine technique for the fast and reliable identification of fungi at the species level and, currently, it represents an important phenotypic methodology based on proteomic profiles. The main limitations to MALDI-TOF MS for fungal identification are related to sample quality (e.g. quality of biological material such as rigidity or pigmentation of cell walls), sample preparation (e.g. the myriad of sample preparation methodologies that deliver different data sets to different MALDI-TOF MS databases) and the databases themselves (e.g. the 'black-box' commercial databases). This chapter presents an overview and discussion of the use of MALDI-TOF MS for fungal identification. The major known limitations of the technique for fungal taxonomy, and how to overcome these, are also discussed.
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Pang, Jihai, and Timothy L. Madden. "Use of Matrix Assisted Laser Desorption/Ionization Imaging Mass Spectrometry (MALDI-IMS) in the Development of Novel Small Molecule Drugs." In LC-MS in Drug Bioanalysis, 399–422. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-3828-1_13.

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Lahiri, Pallavi, Deepika Dhaware, Ajeet Singh, Venkateswarlu Panchagnula, and Dipankar Ghosh. "Quantitation of Neurotoxic Metabolites of the Kynurenine Pathway by Laser Desorption Ionization Mass Spectrometry (LDI-MS)." In Methods in Molecular Biology, 113–29. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9488-5_11.

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Liu, Qiang, Yongsheng Xiao, and Lin He. "Mass Spectrometry Imaging of Small Molecules Using Matrix-Enhanced Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (ME-SALDI-MS)." In Methods in Molecular Biology, 243–52. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-746-4_14.

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Brown, Victoria L., Qiang Liu, and Lin He. "Matrix-Enhanced Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (ME-SALDI-MS) for Mass Spectrometry Imaging of Small Molecules." In Methods in Molecular Biology, 175–84. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1357-2_17.

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Hrabák, Jaroslav. "Detection of Carbapenemases Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) Meropenem Hydrolysis Assay." In Methods in Molecular Biology, 91–96. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1776-1_9.

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Robins, Chad L., Stephen F. Macha, Victor E. Vandell, and Patrick A. Limbach. "Laser Desorption/Ionization (LDI)- and Maldi-Fourier Transform Ion Cyclotron Resonance Mass Spectrometric (FT/ICR/MS) Analysis of Hydrocarbon Samples." In Analytical Advances for Hydrocarbon Research, 405–20. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9212-3_17.

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Russell, Scott C. "Rapid Profiling of Recombinant Protein Expression from Crude Cell Cultures by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS)." In ACS Symposium Series, 61–81. Washington, DC: American Chemical Society, 2011. http://dx.doi.org/10.1021/bk-2011-1065.ch005.

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Strupat, Kerstin, Michael Karas, Franz Hillenkamp, and Christoph Eckerskorn. "Infrared-Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (IR-MALDI-MS) of Proteins Electroblotted onto Polymer Membranes After SDS-PAGE Separation." In Mass Spectrometry in the Biological Sciences, 203–16. Totowa, NJ: Humana Press, 1996. http://dx.doi.org/10.1007/978-1-4612-0229-5_10.

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Lagacé-Wiens, Philippe. "Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF/MS)-Based Identification of Pathogens from Positive Blood Culture Bottles." In Methods in Molecular Biology, 47–55. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1776-1_5.

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Conference papers on the topic "Laser desorption ionization MS"

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Castoro, John A., and Charles L. Wilkins. "Fourier-transform mass spectrometry for high-resolution matrix-assisted laser desorption/ionization MS." In OE/LASE'93: Optics, Electro-Optics, & Laser Applications in Science& Engineering, edited by Mattanjah S. de Vries. SPIE, 1993. http://dx.doi.org/10.1117/12.148521.

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Sen, Ashis K., Jeff Darabi, Ranu Nayak, and Daniel R. Knapp. "Desorption Electrospray Ionization Using a Porous Alumina Surface." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176016.

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Desorption electrospray ionization (DESI) is a technique used for direct sampling of a sample or an analyte deposited on a surface under ambient conditions [1]. In DESI, ionized droplets of a spray are directed towards the sample causing desorption of ions due to exchange of charge and momentum. The resulting ions are carried into an ion trap mass spectrometer and analyzed. DESI was originally demonstrated by Takats et al. [1]. They described the new method and applied the same to analyze various compounds present on a variety of surfaces. Followed by this, several researchers [1–5] have investigated on DESI for a wide range of applications including analysis of pharmaceuticals, explosives detection, natural products discovery and in vivo clinical analysis. Recently, Kauppila et al [5] have introduced porous silicon (pSi) and ultra-thin layer chromatography (UTLC) plates for DESI-MS. Similar or improved sensitivities were obtained with pSi and UTLC surfaces as compared to PMMA and PTFE surfaces. This work presents use of a nanoporous alumina surface [6] for DESI – MS. The DESI – MS performance of nanoporous alumina surface is compared with that of PMMA, which is a popular surface in previous DESI-MS experiments. Optimized operating conditions were determined for the surfaces using BSA tryptic digest as the sample. The results show that the nanoporous alumina surface offers significantly higher ion intensity as compared to the other surfaces.
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Boisard, S., T. Brouté, J. Guerry, M. Škopíková, I. Freuze, C. Solleux, C. Miral, et al. "Characterization of glycosylated flavonoids obtained from enzymatic reaction by matrix free laser desorption ionization mass spectrometry (LDI-MS)." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400149.

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Murray, Kermit K., and David H. Russell. "Matrix-assisted laser desorption ionization of aerosols: The ionization mechanism." In Laser ablation: mechanisms and applications—II. AIP, 1993. http://dx.doi.org/10.1063/1.44843.

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Peixoto, Paulo Henrique Soares, FERNANDO VICTOR MONTEIRO PORTELA, BRUNO NASCIMENTO DA SILVA, MARIA LAÍNA SILVA, and ROSSANA DE AGUIAR CORDEIRO. "PERFIL CLÍNICO-EPIDEMIOLÓGICO DE INFECÇÕES PELO COMPLEXO CANDIDA PARAPSILOSIS EM UM HOSPITAL PEDIÁTRICO TERCIÁRIO." In II Congresso Nacional de Microbiologia Clínica On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conamic/38.

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Introdução: As espécies de Candida estão associadas a diversos tipos de manifestações clínicas e são as principais responsáveis por infecções fúngicas em hospitais terciários. São conhecidas 200 espécies do gênero, dentre essas, destaca-se o Complexo C. parapsilosis, formado pelas espécies C. parapsilosis sensu stricto, C. orthopsilosis e C. metapsilosis, indistinguíveis nos laboratórios de microbiologia clínica. Objetivo: O presente projeto tem como objetivo conhecer o perfil clínico-epidemiológico das infecções de sítios profundos causadas pelo Complexo C. parapsilosis em população pediátrica atendida no Hospital Infantil Albert Sabin (HIAS). Material e métodos: A pesquisa foi aprovada pelo Comité de Ética do hospital em questão (Nº do parecer 4.207.133). Será realizado um estudo prospectivo em um período de 18 meses, iniciado em 11 de agosto de 2020, compreendendo duas etapas: A primeira consiste na triagem das amostras por meio da identificação das espécies em sistema automatizado Vitek® (C. parapsilosis e/ou Candida spp.), isoladas a partir de espécimes clínicos encaminhados ao Laboratório de Análises Clínicas no Setor de Microbiologia do HIAS. A posteriori os isolados serão confirmados com a técnica de Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS). Na segunda etapa, será realizada a coleta de dados dos pacientes de interesse, por meio da análise de prontuários médicos. Resultados: Transcorridos 12 meses do início da pesquisa, 3.514 exames foram positivos para pesquisa de bactérias e fungos e, deste total, 3.066 foram exames de sítios profundos. Até o momento, 101 amostras foram selecionadas para o estudo. 91 amostras foram identificadas como C. parapsilosis e 10 como Candida spp. Foi detectado resistência ao fluconazol em 1 isolados do Complexo C. parapsilosis e 2 isolados de Candida spp., a micafungina 1 isolado do Complexo C. parapsilosis e a fluocitosina 1 isolados de Candida spp. Conclusão: Do total de amostras de interesse, 89 (88,11%) foram de sangue, deste, 59 (58,41%) foram oriundas do Centro Pediátrico do Câncer. O conhecimento da distribuição do patógeno possibilitará ganhos futuros nas abordagens de prevenção e tratamento.
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Meserole, Chad A. "Environment-dependent desorption of benzene molecules." In RESONANCE IONIZATION SPECTROSCOPY 2000: Laser Ionization and Applications Incorporating RIS; 10th International Symposium. AIP, 2001. http://dx.doi.org/10.1063/1.1405603.

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Winston Chen, C. H. "Laser desorption mass spectrometry for biomolecule detection and its applications." In RESONANCE IONIZATION SPECTROSCOPY 2000: Laser Ionization and Applications Incorporating RIS; 10th International Symposium. AIP, 2001. http://dx.doi.org/10.1063/1.1405589.

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Karas, Michael, and Franz Hillenkamp. "Matrix-assisted laser desorption ionization mass spectrometry-fundamentals and applications." In Laser ablation: mechanisms and applications—II. AIP, 1993. http://dx.doi.org/10.1063/1.44841.

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Robson, L. "Analysis of polycyclic aromatic hydrocarbons (PAHs) using nanosecond laser desorption/femtosecond ionization laser mass spectrometry (FLMS)." In RESONANCE IONIZATION SPECTROSCOPY 2000: Laser Ionization and Applications Incorporating RIS; 10th International Symposium. AIP, 2001. http://dx.doi.org/10.1063/1.1405619.

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Böll, Herbvert, Peter Püffel, Christian Weickhardt, and Ulrich Boesl. "Laser desorption/resonance post-ionization of large PAH’s: Ionization and surface specific fragmentation of decacylene." In The 7th international symposium: Resonance ionization spectroscopy 1994. AIP, 1995. http://dx.doi.org/10.1063/1.47559.

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Reports on the topic "Laser desorption ionization MS"

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Zhang, Hui. Developments and Applications of Electrophoresis and Small Molecule Laser Desorption Ionization Mass Spectrometry. Office of Scientific and Technical Information (OSTI), January 2007. http://dx.doi.org/10.2172/933124.

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Young, Steven. Evaluation of the Polymer Characterization Capabilities of Matrix-Assisted Laser Desorption/Ionization (Literature Review). Office of Scientific and Technical Information (OSTI), June 2021. http://dx.doi.org/10.2172/1798113.

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Korte, Andrew R. Development of matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) for plant metabolite analysis. Office of Scientific and Technical Information (OSTI), December 2014. http://dx.doi.org/10.2172/1226566.

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McVey, Patrick. Direct analysis of solid samples by electrospray laser desorption ionization mass spectrometry imaging: From plants to pharmaceuticals. Office of Scientific and Technical Information (OSTI), August 2018. http://dx.doi.org/10.2172/1505182.

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Cha, Sangwon. Laser desorption/ionization mass spectrometry for direct profiling and imaging of small molecules from raw biological materials. Office of Scientific and Technical Information (OSTI), January 2008. http://dx.doi.org/10.2172/976267.

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Eades, D., D. Wruck, and H. Gregg. Fundamental studies of matrix-assisted laser desorption/ionization, using time-of-flight mass spectrometry to identify biological molecules. Office of Scientific and Technical Information (OSTI), November 1996. http://dx.doi.org/10.2172/491767.

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Yagnik, Gargey B. Nanoparticle-assisted laser desorption/ionization mass spectrometry: Novel sample preparation methods and nanoparticle screening for plant metabolite imaging. Office of Scientific and Technical Information (OSTI), February 2016. http://dx.doi.org/10.2172/1342543.

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Mills, Gordon B. Detection of Serum Lysophosphatidic Acids Using Affinity Binding and Surface Enhanced Laser Desorption/Ionization (SELDI) Time of Flight Mass Spectrometry. Fort Belvoir, VA: Defense Technical Information Center, April 2005. http://dx.doi.org/10.21236/ada437186.

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Steele, Paul Thomas. BioAerosol Mass Spectrometry: Reagentless Detection of Individual Airborne Spores and Other Bioagent Particles Based on Laser Desorption/Ionization Mass Spectrometry. Office of Scientific and Technical Information (OSTI), September 2004. http://dx.doi.org/10.2172/15014763.

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Mills, Gordon B. Detection of Serum Lysophosphatidic Acids Using Affinity Binding and Surface Enhanced Laser Desorption/Ionization (SELDI) Time of Flight Mass Spectrometry. Fort Belvoir, VA: Defense Technical Information Center, April 2004. http://dx.doi.org/10.21236/ada427004.

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