Journal articles: 'Lapprya'

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Lin, Song-chow, Tsao-chuen Chung, Chun-ching Lin, Tzuu-Huei Ueng, Yun-ho Lin, Shuw-yuan Lin, and Li-ya Wang. "Hepatoprotective Effects ofArctium Lappaon Carbon Tetrachloride- and Acetaminophen-Induced Liver Damage." American Journal of Chinese Medicine 28, no. 02 (January 2000): 163–73. http://dx.doi.org/10.1142/s0192415x00000210.

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The root of Arctium lappa Linne (A. lappa) (Compositae), a perennial herb, has been cultivated for a long time as a popular vegetable. In order to investigate the hepatoprotective effects of A. lappa, male ICR mice were injected with carbon tetrachloride ( CCl4, 32 μl/kg, i.p.) or acetaminophen (600 mg/kg. i.p.). A. lappa suppressed the SGOT and SGPT elevations induced by CCl4or acetaminophen in a dose-dependent manner and alleviated the severity of liver damage based on histopathological observations. In an attempt to elucidate the possible mechanism(s) of this hepatoprotective effect, glutathione (GSH), cytochrome P-450 (P-450) and malondialdehyde (MDA) contents were studied. A. lappa reversed the decrease in GSH and P-450 induced by CCl4and acetaminophen. It was also found that A. lappa decreased the malondialdehyde (MDA) content in CCl4or acetaminophen-intoxicated mice. From these results, it was suggested that A. lappa could protect the liver cells from CCl4or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4or acetaminophen.

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Jo, Hee-Geun, Geon-Yeong Lee, Chae Yun Baek, Ho Sueb Song, and Donghun Lee. "Analgesic and Anti-Inflammatory Effects of Aucklandia lappa Root Extracts on Acetic Acid-Induced Writhing in Mice and Monosodium Iodoacetate-Induced Osteoarthritis in Rats." Plants 10, no. 1 (December 26, 2020): 42. http://dx.doi.org/10.3390/plants10010042.

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Osteoarthritis (OA) is an age-related joint disease and one of the most common degenerative bone diseases among elderly people. The currently used therapeutic strategies relying on nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids for OA are often associated with gastrointestinal, cardiovascular, and kidney disorders, despite being proven effective. Aucklandia lappa is a well-known traditional medicine. The root of A. lappa root has several bioactive compounds and has been in use as a natural remedy for bone diseases and other health conditions. We evaluated the A. lappa root extracts on OA progression as a natural therapeutic agent. A. lappa substantially reduced writhing numbers in mice induced with acetic acid. Monosodium iodoacetate (MIA) was injected into the rats through their knee joints of rats to induce experimental OA, which shows similar pathological characteristics to OA in human. A. lappa substantially reduced the MIA-induced weight-bearing of hind limb and reversed the cartilage erosion in MIA rats. IL-1β, a representative inflammatory mediator in OA, was also markedly decreased by A. lappa in the serum of MIA rats. In vitro, A. lappa lowered the secretion of NO and suppressed the IL-1β, COX-2, IL-6, and iNOS production in RAW264.7 macrophages activated with LPS. Based on its analgesic and anti-inflammatory effects, A. lappa could be a potential remedial agent against OA.

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Alotaibi, Amal A., Asmatanzeem Bepari, Rasha Assad Assiri, Shaik Kalimulla Niazi, Sreenivasa Nayaka, Muthuraj Rudrappa, Shashiraj Kareyellapa Nagaraja, and Meghashyama Prabhakara Bhat. "Saussurea lappa Exhibits Anti-Oncogenic Effect in Hepatocellular Carcinoma, HepG2 Cancer Cell Line by Bcl-2 Mediated Apoptotic Pathway and Mitochondrial Cytochrome C Release." Current Issues in Molecular Biology 43, no. 2 (September 8, 2021): 1114–32. http://dx.doi.org/10.3390/cimb43020079.

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Background and Objectives: Saussurea lappa (S. lappa) is an important species of the Asteraceae family with several purposes in traditional medicine. This study intended to explore the cytotoxic effect of S. lappa on HepG2 cancer cell proliferation. Materials and Methods: The effects of an S. lappa n-butanol extract on the induction of apoptosis were investigated by flow cytometry and mitochondrial cytochrome C-releasing apoptosis assay. Additionally, real-time PCR was employed to confirm apoptosis initiation. Further, qualitative estimation of the active constituent of S. lappa was done by gas chromatography–mass spectroscopy (GC–MS). Results: The cell viability study revealed that the n-butanol extract of S. lappa demonstrated potent cytotoxicity against HepG2 cancer cells, with an IC50 value of 56.76 μg/mL. Cell morphology with dual staining of acridine orange (AO)-ethidium bromide (EB) showed an increase in orange/red nuclei due to cell death by S. lappa n-butanol extract compared to control cells. Apoptosis, as the mode of cell death, was also confirmed by the higher release of cytochrome C from mitochondria, the increased expression of caspase-3 and bax, along with down regulation of Bcl-2. Conclusion: These findings conclude that S. lappa is a cause of hepatic cancer cell death through apoptosis and a potential natural source suggesting furthermore investigation of its active compounds that are responsible for these observed activities.

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Muhammad Ikbal and Muhammad Rudi. "PENGARUH FAKTOR EKONOMI TERHADAP PENJUALAN RUMAH SUBSIDI (STUDI KASUS DI PERUMAHAN BUMI LAPPA MAS KABUPATEN SINJAI)." Jurnal Adz-Dzahab: Jurnal Ekonomi dan Bisnis Islam 4, no. 1 (May 20, 2019): 50–61. http://dx.doi.org/10.47435/adz-dzahab.v2i1.344.

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Penelitian ini bertujuan untuk membuktikan pengaruh faktor ekonomi terhadap penjualan rumah subsidi di perumahan Bumi Lappa Mas dan untuk mengetahui besaran pengaruh faktor ekonomi terhadap penjualan rumah subsidi di perumahan Bumi Lappa Mas. Faktor ekonomi dalam mempengaruhi penjualan rumah subsidi di perupahan Bumi Lappa Mas merupakan daya yang timbul dari peristiwa yang mempengaruhi segala sesuatu yang berhubungan dengan tindakan ekonomi dalam pemenuhan kebutuhan masyarakat berupa faktor harga penjualan rumah, besarnya pembayaran angsuran/cicilan, dan tingkat pendapatan/penghasilan masyarakat terhadap penjualan rumah subsidi Bumi Lappa Mas Kabupaten Sinjai. Hasil penelitian ini menyimpulkan bahwa 1) Faktor ekonomi memiliki pengaruh positif dan signifikan terhadap penjualan rumah subsidi di perumahan Bumi Lappa Mas. Hal ini diperoleh berdasarkan analisis dengan menggunakan SPSS 16, diketahui t-hitung faktor ekonomi 7,732 > 2,020 (t-tabel) dan nilai probabilitas 0,000 < 0,05. 2) Besaran pengaruh faktor ekonomi terhadap penjualan rumah subsidi di perumahan Bumi Lappa Mas adalah 59% dan sisanya dipengaruhi oleh sebab-sebab lain (yang tidak diteliti). -2,647.

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Shaulo, Dmitry N., Elena Yu Zykova, Natalia N. Tupitsyna, Nina I. Molokova, Alexandra E. Sonnikova, Nadezhda V. Saak, Rada B. Shanmak, Anna D. Sambuu, Evgeny S. Ankipovich, and Alexander I. Shmakov. "Floristic findings in the Upper Yenisei basin: Krasnoyarsk Territory, Republic of Tuva." Turczaninowia 24, no. 1 (March 28, 2021): 117–24. http://dx.doi.org/10.14258/turczaninowia.24.1.14.

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During field research, viewing materials stored in the herbaria of the Central Siberian Botanical Garden SB RAS (NS), Krasnoyarsk State Pedagogical University named after V. P. Astafyev (KRAS), the “Sayano-Shushensky” State Natural Biosphere Reserve (SSHZ) and the “Azas” State Nature Reserve, clarified information on the distribution of rare plant species in the Upper Yenisei basin. For the first time in the flora of the Krasnoyarsk Territory, 4 species were found: Allium eduardi, Ephedra gerardiana, Lappula tuvinica, Taraxacum sajanense; there are 5 species in Tuva: Kochia scoparia, Microstigma sajanense, Polygonum salsugineum, P. turkestanicum, Potentilla canescens. For the first time, 3 species were registered in the Western Sayan mountain system: Astragalus brevifolius, Kochia scoparia and Taraxacum sajanense. For 13 rare species, new locations were noted and the boundaries of the ranges were specified: Astragalus macroceras, Dontostemon pinnatifidus, Elymus pendulinus, Fritillaria dagana, Lappula heteracantha, L. semiglabra var. dsharkentica, L. tuvinica, Orchis militaris and others. The new ones for the “Sayano-Shushensky” State Natural Biosphere Reserve were 4 species: Allium eduardi, Elymus pendulinus, Ephedra gerardiana, Lappula tuvinica. Orchis militaris was first found for the “Azas” State Nature Reserve.

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Lin, Chun-Ching, Jer-Min Lin, Jeng-Jer Yang, Shu-Chuan Chuang, and Takashi Ujiie. "Anti-inflammatory and Radical Scavenge Effects of Arctium lappa." American Journal of Chinese Medicine 24, no. 02 (January 1996): 127–37. http://dx.doi.org/10.1142/s0192415x96000177.

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The effects of Arctium lappa L. (root) on anti-inflammatory and free radical scavenger activity were investigated. Subcutaneous administration of A. lappa crude extract significantly decreased carrageenan-induced rat paw edema. When simultaneously treated with CCl4, it produced pronounced activities against CCl4-induced acute liver damage. The free radical scavenging activity of its crude extract was also examined by means of an electron spin resonance (ESR) spectrometer. The IC50 of A. lappa extract on superoxide and hydroxyl radical scavenger activity was 2.06 mg/m 11.8 mg/m1, respectively. These findings suggest that Arctium lappa possess free radical scavenging activity. The inhibitory effects on carrageenan-induced paw edema and CCl4-induced hepatotoxicity could be due to the scavenging effect of A. lappa.

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Abd El-Rahman, Ghada I., Amany Behairy, Nora M. Elseddawy, Gaber El-Saber Batiha, Wael N. Hozzein, Dina M. Khodeer, and Yasmina M. Abd-Elhakim. "Saussurea lappa Ethanolic Extract Attenuates Triamcinolone Acetonide-Induced Pulmonary and Splenic Tissue Damage in Rats via Modulation of Oxidative Stress, Inflammation, and Apoptosis." Antioxidants 9, no. 5 (May 8, 2020): 396. http://dx.doi.org/10.3390/antiox9050396.

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Background: In this era, worldwide interest has been directed towards using natural antioxidants to guard against drug side effects. Saussurea lappa is a famous medicinal plant with many biologically active compounds. Triamcinolone acetonide (TA) is an extensively used glucocorticoid. Hence, this study explored, for the first time, the possible beneficial effects of S. lappa ethanolic extract on TA-induced oxidative damage in the lung and spleen of rats. Methods: Five experimental groups were used: control group, S. lappa-treated group (600 mg/kg/day, orally), TA-treated group (40 mg/kg/twice/week I/P), S. lappa + TA co-treated group, and S. lappa/TA prophylactic group. Results: TA exposure significantly induced leukocytosis and neutrophilia. In addition, TA significantly reduced the levels of C-reactive protein, interleukin-12, tumor necrosis factor α, and immunoglobulins. Lung Caspase-3 overexpression and splenic CD8+ downregulation were also noted in the TA group. TA treatment significantly increased malondialdehyde concentration but reduced superoxide dismutase and glutathione peroxidase activities. S. lappa counteracted the TA oxidative and apoptotic effects. The best results were recorded in the prophylactic group. Conclusions: S. lappa has a remarkable protective effect via its anti-inflammatory, anti-apoptotic, and antioxidant capacity. Thus, it could be a candidate as a natural antioxidant to face glucocorticoid’s harmful side effects.

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Watanabe, Aya, Hiroyuki Sasaki, Hiroki Miyakawa, Yuki Nakayama, Yijin Lyu, and Shigenobu Shibata. "Effect of Dose and Timing of Burdock (Arctium lappa) Root Intake on Intestinal Microbiota of Mice." Microorganisms 8, no. 2 (February 6, 2020): 220. http://dx.doi.org/10.3390/microorganisms8020220.

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Water-soluble dietary fiber such as inulin improves the beta diversity of the intestinal microbiota of mice fed with a high-fat diet (HFD). The circadian clock is the system that regulates the internal daily rhythm, and it affects the pattern of beta diversity in mouse intestinal microbiota. Burdock (Arctium lappa) root contains a high concentration of inulin/fructan (approximately 50%) and is a very popular vegetable in Japan. Arctium lappa also contains functional substances that may affect intestinal microbiota, such as polyphenols. We compared the effects of inulin and A. lappa powder on the diversity of the intestinal microbiota of HFD-fed mice. 16S rDNA from the intestinal microbiota obtained from feces was analyzed by 16S Metagenomic Sequencing Library Preparation. It was found to have a stronger effect on microbiota than inulin alone, suggesting that inulin has an additive and/or synergic action with other molecules in A. lappa root. We examined the effects of intake timing (breakfast or dinner) of A. lappa on intestinal microbiota. The intake of A. lappa root in the evening had a stronger effect on microbiota diversity in comparison to morning intake. Therefore, it is suggested that habitual consumption of A. lappa root in the evening may aid the maintenance of healthy intestinal microbiota.

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Idrissova, G. Z., I. V. Sergeeva, E. N. Shevchenko, A. L. Ponomareva, and K. M. Akhmedenov. "Bioecological Characteristics of the Flora of the Territories Adjacent to the Springs of Western Kazakhstan." Povolzhskiy Journal of Ecology, no. 4 (February 14, 2020): 419–31. http://dx.doi.org/10.35885/1684-7318-2019-4-419-431.

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The data of floristic studies of 40 spring tracts of the Mangistau, Aktobe, Atyrau and West Kazakhstan regions of the Western Region of the Republic of Kazakhstan are presented. We have found that the studied flora is represented by 252 species, 167 genera and 55 families belonging to Equisetophyta, Pinophyta, and Magnoliophyta divisions. Taxonomic characterization of the flora showing the predominance of the Asteraceae and Poaceae families is provided. The predominance of perennial herbaceous plants in the flora of spring tracts was identified by the system of I. G. Serebryakov’s life forms. The predominance of steppe plants and weeds was revealed. Horological analysis showed the leading set of species with the Eurasian range type. Ecological characteristics highlighted the predominance of xerophytes and mesotrophic plants. 20 protected plant species listed in the Red Data Book of the Russian Federation and the Red Data Book of the Republic of Kazakhstan were identified. Analysis of the distribution of plants in the areas adjacent to the springs identified four grades of occurrence, namely: common species – 7; uncommon species – 17; rare species – 100; and very rare species – 128. The most common species found within the spring tract territories are related to weeds, such as Tripleurospermum perforatum (Merat) M. Lainz, Polygonum aviculare L., Taraxacum officinale Wigg., Lappula squarrosa (Retz.) Dumort., Plantago major L., Arctium lappa L., Xanthium strumarium L., Capsella bursa-pastoris (L.) Medik., Chenopodium album L., Convulvus arvensis L., Poa annua L., Bromus squarrosus L., Elytrigia repens (L.) Nevski. The Jaccard index (Kj) for the analyzed floras in pairwise comparison varies from 0.02 to 0.5, which shows the extreme heterogeneity of the specific composition.

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Fellman, Jacob. "The Thief and the Shaman." Nordlit 8, no. 1 (July 1, 2004): 5. http://dx.doi.org/10.7557/13.1904.

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Nie, Liping, Yingxian Cui, Xinlian Chen, Zhichao Xu, Wei Sun, Yu Wang, Jingyuan Song, and Hui Yao. "Complete chloroplast genome sequence of the medicinal plant Arctium lappa." Genome 63, no. 1 (January 2020): 53–60. http://dx.doi.org/10.1139/gen-2019-0070.

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Arctium lappa, commonly called burdock, has a long medicinal and edible history. It has recently gained increasing attention because of its economic value. In this study, we obtained the complete chloroplast genome of A. lappa by Illumina Hiseq. The complete chloroplast genome of A. lappa is a typical circular structure with 152 708 bp in length. The GC content in the whole chloroplast genome of A. lappa is 37.7%. A total of 37 tRNA genes, 8 rRNA genes, and 87 protein-coding genes were successfully annotated. And the chloroplast genome contains 113 unique genes, 19 of which are duplicated in the inverted repeat. The distribution of 39 simple sequence repeats was analysed, and most of them are in the large single-copy (LSC) sequence. An inversion comprising 16 genes was found in the LSC region, which is 26 283 bp long. We performed multiple sequence alignments using 72 common protein-coding genes of 29 species and constructed a Maximum Parsimony (MP) tree. The MP phylogenetic result shows that A. lappa grouped together with Carthamus tinctorius, Centaurea diffusa, and Saussurea involucrata. The chloroplast genome of A. lappa is a valuable resource for further studies in Asteraceae.

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-, Budiyamin, Suryawati Salam, and Hadijah -. "Distibution Analysis Of Skipjeck Katsuwonus Pelamis In Sinjai Regency (Case Study On Fish Landed Ppi Lappa In Sinjai Regency)." Journal of Aquaculture and Environment 1, no. 1 (March 13, 2019): 33–38. http://dx.doi.org/10.35965/jae.v1i1.37.

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The distribution pattern of Skipjack in PPI/TPI Lappa through three patterns disribusi namely: Fisherman (producer) - Retailers - small traders – top consumers Fisherman (producer) - small traders – top consumer Fisherman (producer) - wholesaler – consumer. Amount of margin, profit and marketing efficiency of marketing agencies skipjack in TPI Lappa sequential as follows: Fishermen with margin Rp. 33,750/Kg, advantages Rp. 33,750/Kg and 0.53% efficiency, Small Traders with a margin of Rp. 4,250/Kg, a profit of Rp. 3,549/Kg and efficiency of 1.87% with a margin Wholesalers Rp. 10,000/kg, a profit of Rp. 9,249/Kg and 1.72% Efficiency Retailers with a margin of Rp3,750/Kg, profit Rp.3,379/Kg and efficiency of 0.99%. The need to conduct further research on the patterns of distribution marketing for kinds of fish landed in PPI Lappa so that the distribution pattern of fish landed marketing can be known thoroughly kinds of fish landed in PPI Lappa.

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Ibrahim Abdelwahab, Siddig, Shyam Sunder Pancholi, Syam Mohan, Muhammad Hadi Sultan, Pankaj Tripathi, Saeed Alshahrani, Mohammed Abdul Hakim Sidiqui, Abdullah Farasani, and Manal Mohamed Elhassan Taha. "Antinociceptive Activity of the Essential Oil Formulation from the Roots of Saussaura lappa Clarks." Current Topics in Nutraceutical Research 19, no. 2 (June 10, 2020): 127–32. http://dx.doi.org/10.37290/ctnr2641-452x.19:127-132.

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Saussurea lappa Clarke (Compositae) is well known as a medicinal plant. Its roots are traditionally used in alleviating pain and swelling. In the current research, we have evaluated the antinociceptive activity of essential oil obtained from the roots of S. lappa. In addition, the development and evaluation of a pharmaceutical-grade cream was also conducted in this study. Extraction of essential oil from the roots of the plant was performed by a steam distillation method using the Clevenger apparatus. The antinociceptive activity was assessed in Sprague Dawley rats using tail flick, hot plate, and analgesic-meter, where diclofenac was used as a standard reference analgesic agent. S. lappa showed analgesic activity in all test systems in a dose- and time-dependent manner. In addition, the formulated cream obtained from the essential oil showed very promising pharmaceutical and pharmacological properties. The analgesic activity of S. lappa may be due to its interaction with opioid receptors and involvement of peripheral analgesia. The ability of S. lappa to show both slow- and fast-onset analgesic effects suggests it could be used as a drug candidate for pain management. The current findings thus warrant further research in the development of this novel analgesic agent.

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Kim, Young-Kyu, Sushruta Koppula, Do-Wan Shim, Eun-Jung In, Su-Bin Kwak, Myong-Ki Kim, Sang-Hyeun Yu, Kwang-Ho Lee, and Tae-Bong Kang. "Inhibitory Effect and Mechanism of Arctium lappa Extract on NLRP3 Inflammasome Activation." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/6346734.

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Arctium lappa (A. lappa), Compositae, is considered a potential source of nutrition and is used as a traditional medicine in East Asian countries for centuries. Although several studies have shown its biological activities as an anti-inflammatory agent, there have been no reports on A. lappa with regard to regulatory role in inflammasome activation. The purpose of this study was to investigate the inhibitory effects of A. lappa extract (ALE) on NLRP3 inflammasome activation and explore the underlying mechanisms. We found that ALE inhibited IL-1β secretion from NLRP3 inflammasome activated bone marrow derived macrophages but not that secreted by NLRC4 and AIM2 inflammasomes activation. Mechanistic studies revealed that ALE suppressed the ATPase activity of purified NLRP3 and reduced mitochondrial reactive oxygen species (mROS) generated during NLRP3 activation. Therefore, the inhibitory effect of ALE on NLRP3 inflammasome might be attributed to its ability to inhibit the NLRP3 ATPase function and attenuated the mROS during inflammasome activation. In addition, ALE significantly reduced the LPS-induced increase of plasma IL-1β in mouse peritonitis model. These results provide evidence of novel anti-inflammatory mechanisms of A. lappa, which might be used for therapeutic applications in the treatment of NLRP3 inflammasome-associated inflammatory disorders.

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Skowrońska, Weronika, Sebastian Granica, Magdalena Dziedzic, Justyna Kurkowiak, Maria Ziaja, and Agnieszka Bazylko. "Arctium lappa and Arctium tomentosum, Sources of Arctii radix: Comparison of Anti-Lipoxygenase and Antioxidant Activity as well as the Chemical Composition of Extracts from Aerial Parts and from Roots." Plants 10, no. 1 (January 2, 2021): 78. http://dx.doi.org/10.3390/plants10010078.

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Arctium lappa is a weed used in traditional medicine in the treatment of skin inflammation and digestive tract diseases. Arctium tomentosum is used in folk medicine interchangeably with Arctium lappa and, according to European Medicines Agency (EMA) monography, provides an equal source of Arctii radix (Bardanae radix), despite the small amount of research confirming its activity and chemical composition. The aim of the study was the comparison of the anti-lipoxygenase and the antioxidant activity, scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion (O2•−), and hydrogen peroxide (H2O2), of 70 % (v/v) ethanolic extracts from the aerial parts and the roots of Arctium lappa and Arctium tomentosum. In the tested extracts, the total polyphenols content and the chemical composition, analyzed with the HPLC–DAD–MSn method, were also compared. The extracts were characterized by strong antioxidant properties, but their ability to inhibit lipoxygenase activity was rather weak. A correlation between the content of polyphenolic compounds and antioxidant activity was observed. The extracts from A. lappa plant materials scavenged reactive oxygen species more strongly than the extracts from A. tomentosum plant materials. Moreover, the extracts from A. lappa plant materials were characterized by the statistically significantly higher content of polyphenolic compounds.

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Riaz, Muhammad, Muhammad Altaf, Amir Faisal, Muhammad Azhar Shekheli, Ghulam Abbass Miana, Muhammad Qayyum Khan, Muhammad Ali Shah, Syed Zafar Ilyas, and Ayaz Arif Khan. "Biogenic Synthesis of AgNPs with Saussurea lappa C.B. Clarke and Studies on Their Biochemical Properties." Journal of Nanoscience and Nanotechnology 18, no. 12 (December 1, 2018): 8392–98. http://dx.doi.org/10.1166/jnn.2018.16414.

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Nanotechnology has become an irreplaceable need and green synthesis of nanoparticles offers several advantages over physical and chemical methods. Medicinal plants are the main reservoirs of drugs and drug candidates. We report the biogenic synthesis of silver nanoparticles (AgNPs) using aqueous root extract of Saussurea lappa. Verification and characterization of these nanoparticles were done by UV-visible spectroscopy, XRD-analysis and Scanning Electron Microscopy and FT-IR. Extract-loaded-AgNPs showed the highest inhibition zone against Escherichia coli (11.0 mm) and intermediate against Pseudomonas aeruginosa (9.0 mm). The methanolic root extract of S. lappa alone, also moderately inhibited Pseudomonas aeruginosa (9.0 mm) and showed lower activity (6.0 mm) against Escherichia coli. Its aqueous roots extract inhibited (6.0 mm) the growth of tested organisms. Methanolic extract showed antioxidant potency (IC50 = 0.814 μg/mL). Experiments revealed the presence of phenols and flavonoids in the roots of Saussurea lappa. These findings provide promising interest to exploit Saussurea lappa for the biogenic synthesis of AgNPs and their biological applications.

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Kaewsomboon, T., Komgrit Sawangkan, and Chutimon Satirapipathkul. "Characterization of Konjac Glucomannan Film Containing the Extracts of Atractylodes lancea and Saussurea lappa." Advanced Materials Research 506 (April 2012): 401–4. http://dx.doi.org/10.4028/www.scientific.net/amr.506.401.

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The antibacterial properties of konjac glucomannan (KGM) film containing two herb extracts (Atractylodes lancea and Saussurea lappa) at various concentrations was studied in this present work. This activity was tested against two pathogenic bacteria, Bacillus subtilis and Staphylococcus aureus. The results showed that the mean value of inhibition zone diameter of incorporated films with Saussurea lappa extracts were higher than those incorporating Atractylodes lancea extracts for all concentrations. The film incorporated with S. lappa extract had higher antibacterial activity against both bacteria than incorporated with A. lamcea. For all these levels, it can be seen that the KGM film had satisfactory physical properties and antibacterial activities.

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Дьякова (Dyakova), Нина (Nina) Алексеевна (Аlekseevna). "DEVELOPMENT AND VALIDATION OF THE EXPRESS TECHNIQUE OF ALLOCATION AND QUANTITATIVE DEFINITION OF WATER-SOLUBLE POLYSACCHARIDES OF LEAVES OF ARCTIUM LAPPA L." chemistry of plant raw material, no. 4 (December 11, 2018): 81–87. http://dx.doi.org/10.14258/jcprm.2018042195.

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Research objective was development of an express technique of allocation and quantitative definition of water-soluble polysaccharides in leaves of a Arctium lappa L. For acceleration of process of extraction of biologically active agents of leaves of a Arctium lappa and also augmentations of an exit of water-soluble polysaccharides, it was decided to use an ultrasonic bathtub. Varying process indicators, it was succeeded to pick up extraction conditions under which process of extraction and quantitative definition of water-soluble polysaccharides of leaves of a Arctium lappa comes down to 1.5 h, namely: an izmelchennost of raw materials of 0.5–1.0 mm, temperature – 80 °С, frequency rate of extraction – 3, duration of extractions – 15 min, ultrasound frequency – 35 kHz, a ratio of raw materials and the ekstragent of 1 g for 15 ml. The developed technique of a validirovan on indicators of repeatability, correctness, fastness and linearity therefore it is proved that it is a pretsizionna in the conditions of repeatability, is correct, steady and has rather rigid linear dependence of mass of a deposit on mass of the analyzed raw materials at gravimetric definition of water-soluble polysaccharides in leaves of а Arctium lappa. The technique can be used for the express analysis of quality of leaves of а Arctium lappa and also at industrial receiving an inulin from this type of raw materials.

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Ribeiro, Mário Sérgio, Luiz Cláudio Ribeiro, and Rafael Augusto Ferreira. "A possible contribution to improving the therapeutic potentials of Babor's Typology of Alcohol Dependent Patients." Jornal Brasileiro de Psiquiatria 64, no. 3 (September 2015): 200–206. http://dx.doi.org/10.1590/0047-2085000000079.

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ABSTRACT Objective The objective of this study was to replicate Babor's Typology and to explore clinical features related to personality traits that may underlie this classification, in order to improve its therapeutic possibilities. Methods Observational prospective study on a group of 273 male alcoholics. After a replication of Babor's variables, Cluster Analysis, Chi-Square – applied on clinical variables related to a Lappda Tipology – and Kappa tests were performed. Results The study identified two distinct clusters that held similar features to those described for the Type A/Type B classification. Besides presenting a lower socio-economic situation, Cluster 2 patients were associated with higher vulnerability and severe clinical features and also differed from Cluster 1 in their response to treatment. These replicated clusters retained connections and also differences in relation to the variables derived from the Lappda Typology. Conclusion Considering that each of the two replicated clusters seem to be associated to different personality traits – according to their correlations to the affective, cognitive and behavioral dimensions brought forward by the Lappda Typology – it is acceptable that this study may contribute to the development of more comprehensive and effective therapeutic strategies specifically tailored to target more specific personality traits of these subgroups of alcoholic patients.

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Teixeira, Renan S., Paulo H. D. Carvalho, Jair A. K. Aguiar, Valquíria P. Medeiros, Ademar A. Da Silva Filho, and Jorge W. L. Nascimento. "Improved Method for Obtaining of Arctigenin from Arctium Lappa L. and its Antiproliferative Effect on Human Hepatocarcinoma HepG2 Cells." Current Bioactive Compounds 16, no. 3 (June 10, 2020): 358–62. http://dx.doi.org/10.2174/1573407214666181115124223.

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Background: Arctigenin is a lignan found in Arctium lappa L. (Asteraceae) that displays anti-inflammatory activities. Previous studies showed that the crude extract of A. Lappa has antitumor activity in human liver carcinoma, lung and stomach cancer cells. The aim of this study was to obtain arctigenin from A. lappa L., as well as to evaluate its antiproliferative effects in cells of liver carcinoma (HepG2) and fibroblasts (NIH/3T3). Methods: Arctigenin was obtained from the hydrolysis of arctiin, which was isolated from the crude extract of A. lappa. The effects of arctigenin and arctiin on HepG2 cell viability and cell adhesion were analyzed by MTT method. Adhesion assay was also carried out to evaluate the antitumor activity. Results: Our results showed that the analytical process to obtain arctigenin was fast and easy. In vitro experiments showed that arctigenin (107-269 μM) decreased HepG2 cells viability and did not cause cytotoxicity on NIH/3T3 cells. Arctigenin (27-269 μM) demonstrated anti-adhesion in HepG2 cells in a concentration-dependent manner, when compared with control. Conclusion: These results suggest a promising pharmacological activity for arctigenin as an antiproliferative compound.

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Fontana, Pâmela Dias, Lorena Bavia, Fernanda Bovo, Ariádine Reder C. de Souza, Marcos Lúcio Corazza, and Iara Jose Messias-Reason. "Supercritical Extracts from Arctium lappa as a Potential Inhibitor for the Activation of Complement System." Planta Medica International Open 6, no. 02 (November 2019): e63-e69. http://dx.doi.org/10.1055/a-1025-0085.

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Abstract Arctium lappa is a perennial species of the Asteraceae family originally from Europe and Asia. Considered a weed species in the southern region of Brazil, it is popularly used as a natural anti-inflammatory. The complement system is an important component of the innate immune response. However, its exacerbated activation can lead to harmful conditions like autoimmune and inflammatory disorders. Plants that inhibit the activation of complement can be a promising tool in the treatment of inflammatory diseases. Here, we evaluated the effect of A. lappa leaves extracts on the activation of the classical and alternative pathways of complement system. Two extracts were obtained under supercritical conditions using scCO2 with ethanol as cosolvent, at 313.15K, 15 MPa (E1) and 25 MPa (E2). Classical and alternative activation were evaluated using complement fixation test. Different concentrations of A. lappa extracts E1 and E2 showed an inhibitory effect on both complement pathways, and heparin was used as control. The IC50 of E1, E2, and heparin were 28.26, 20.12 and 92.54 µg/mL for classical and 26.12, 27.70, 27.78 µg/mL for the alternative pathway. Results demonstrate that A. lappa is a promising complementary treatment for diseases associated with complement activation.

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N. Adham, Aveen, Mohamed Elamir F. Hegazy, Alaadin M. Naqishbandi, and Thomas Efferth. "Induction of Apoptosis, Autophagy and Ferroptosis by Thymus vulgaris and Arctium lappa Extract in Leukemia and Multiple Myeloma Cell Lines." Molecules 25, no. 21 (October 29, 2020): 5016. http://dx.doi.org/10.3390/molecules25215016.

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Thymus vulgaris and Arctium lappa have been used as a folk remedy in the Iraqi Kurdistan region to deal with different health problems. The aim of the current study is to investigate the cytotoxicity of T. vulgaris and A. lappa in leukemia and multiple myeloma (MM) cell lines and determine the mode of cell death triggered by the most potent cytotoxic fractions of both plants in MM. Resazurin assay was used to evaluate cytotoxic and ferroptosis activity, apoptosis, and modulation in the cell cycle phase were investigated via Annexin V-FITC/PI dual stain and cell-cycle arrest assays. Furthermore, we used western blotting assay for the determination of autophagy cell death. n-Hexane, chloroform, ethyl acetate, and butanol fractions of T. vulgaris and A. lappa exhibited cytotoxicity in CCRF-CEM and CEM/ADR 5000 cell lines at concentration range 0.001–100 μg/mL with potential activity revealed by chloroform and ethyl acetate fractions. NCI-H929 displayed pronounced sensitivity towards T. vulgaris (TCF) and A. lappa (ACF) chloroform fractions with IC50 values of 6.49 ± 1.48 and 21.9 ± 0.69 μg/mL, respectively. TCF induced apoptosis in NCI-H929 cells with a higher ratio (71%), compared to ACF (50%) at 4 × IC50. ACF demonstrated more potent autophagy activity than TCF. TCF and ACF induced cell cycle arrest and ferroptosis. Apigenin and nobiletin were identified in TCF, while nobiletin, ursolic acid, and lupeol were the main compounds identified in ACF. T. vulgaris and A. lappa could be considered as potential herbal drug candidates, which arrest cancer cell proliferation by induction of apoptosis, autophagic, and ferroptosis.

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Dhillon, R. S., P. S. Kalsi, W. P. Singh, V. K. Gautam, and B. R. Chhabra. "Guaianolide from Saussurea lappa." Phytochemistry 26, no. 4 (January 1987): 1209–10. http://dx.doi.org/10.1016/s0031-9422(00)82384-5.

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Jeelani, S., and M. A. Khuroo. "Triterpenoids from Arctium lappa." Natural Product Research 26, no. 7 (August 18, 2011): 654–58. http://dx.doi.org/10.1080/14786419.2010.541886.

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Kalsi, P. "Guaianolides from Saussurea lappa." Phytochemistry 40, no. 6 (December 1995): 1713–15. http://dx.doi.org/10.1016/0031-9422(95)00353-9.

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Jung, Jee Hyung, Youngsoo Kim, Chong-Ock Lee, Sam Sik Kang, Jong-Hee Park, and Kwang Sik Im. "Cytotoxic constituents ofSaussurea lappa." Archives of Pharmacal Research 21, no. 2 (April 1998): 153–56. http://dx.doi.org/10.1007/bf02974020.

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Tejaswi, Juluri Krishna Dutta, R. Govinda Rajan, and P. Sara. "BIOLOGICAL EVALUATION OF SAUSSUREA LAPPA ROOT EXTRACT FOR ANALGESIC AND ANTI- INFLAMMATORY ACTIVITY." Asian Journal of Pharmaceutical Research and Development 6, no. 4 (August 23, 2018): 35–38. http://dx.doi.org/10.22270/ajprd.v6i4.378.

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The present study was designed to evaluate the Phytochemical Screening for Analgesic and Anti- inflammatory activities of Ethonolic extract of Saussurea lappa. The collected plant root material were washed, shade dried, and size reduced into small pieces. Dried materials were coarsely powdered and macerated with petroleum ether for 72 hrs. The plant material was extracted by using ethanol by the cold maceration method. The study concluded that the root extract have potential bioactive substances that may be used to formulate new drugs. The Flavo-Glycosides content in Ethonolic extract of Saussurea lappa root was extracted and results were compared with the standard for Analgesic and Anti- inflammatory activities. The results were compared with the standard using statistical method. However further investigation was required for structural elucidation and pharmacological properties. Keywords: Saussurea lappa, Ethonolic, Glycosides, Analgesic, Anti-inflammatory.

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Hassan, Reyaz, and Mubashir Hussain Masoodi. "Saussurea lappa: A Comprehensive Review on its Pharmacological Activity and Phytochemistry." Current Traditional Medicine 6, no. 1 (January 8, 2020): 13–23. http://dx.doi.org/10.2174/2215083805666190626144909.

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Around 3000 species of Saussurea are known, however Saussurea lappa Clarke which is perennial herb and has been traditionally used as anticancer, anti-inflammatory, antiviral, medicine without many adverse effects. Phytochemistry of Saussurea lappa after thorough literature survey revealed various varied and copious metabolites such as sesquiterpenes, flavonoids, phytosterols, lignans, terpenes. Many of these compounds have been found to possess a wide range of biological activity such as anticancer, anti-inflammatory, anti-hepatotoxic, anti-viral, etc. Among sesquiterpenes particularly Dehydrocostuslactone, dihydrocostunolide, costunolide Lappadilactone, have been isolated as the main chemical constituents. This review aims to cover published work from public databases (e.g. PubMed, Google Scholar, ResearchGate) and Non-English, Ph.D./MS thesis databases (e.g. CKNIChina, Jairo-Japan, Myto-Malaysia, Shodhganga-India) with a particular focus on phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Saussurea lappa.

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Fante, Camila Argenta, Solange Dieterish, and Rubens Rodriguez. "Betametasona e extrato aquoso de Arctium lappa no tratamento da angiostrongilíase." Revista da Sociedade Brasileira de Medicina Tropical 41, no. 6 (December 2008): 654–57. http://dx.doi.org/10.1590/s0037-86822008000600018.

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Angiostrongylus costaricensis é um parasita que causa angiostrongilíase abdominal em humanos, seu tratamento inclui o uso de antiinflamatórios apesar da falta de estudos que justifiquem esta conduta. O objetivo deste artigo é avaliar o efeito da betametasona e da Arctium lappa na evolução de lesões intestinais induzidas pelo parasita. Utilizou-se camundongos Swiss, machos, adultos, distribuídos em 4 grupos: infectados tratados com betametasona; com Arctium lappa; não tratados e grupo controle. Os tratamentos iniciaram no 15º dia de infecção e permaneceram por 15 dias. Infiltrado eosinofílico e granuloma foram avaliados (1-leve; 2-moderado; 3-severo). A betametasona permitiu a evolução das lesões para formas mais graves, enquanto o extrato não interferiu na progressão da patologia. As substâncias empregadas não mostraram eficácia na proteção das lesões induzidas pelo Angiostrongylus costaricensis em camundongos. Estes achados desmotivam o uso de betametasona e Arctium lappa em humanos acometidos por angiostrongilíase abdominal.

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CONEA, Simona, Cristina MOGOSAN, Oliviu VOSTINARU, Claudia Crina TOMA, Ioana CUC HEPCAL, Irina CAZACU, Cristina POP, and Laurian VLASE. "Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 45, no. 1 (June 10, 2017): 59–64. http://dx.doi.org/10.15835/nbha45110549.

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The aim of the study was to assess the polyphenolic profile, anti-inflammatory and antinociceptive activity of Arctium lappa, a medicinal plant traditionally used in the treatment of gout, hepatitis and other inflammatory disorders. Polyphenolic profile of a hydro-glycero-ethanolic extract from Arctium lappa roots (ALE) was evaluated by HPLC-MS method. Anti-inflammatory effect of the Arctium lappa extract (ALE) was determined by carrageenan-induced rat paw oedema test, while antinociceptive effect was determined by acetic acid induced writhing test in mice and Randall Selitto test in rats. HPLC-MS analysis of the extract showed the presence of chlorogenic acid (158.9 μg/mL) and quercitrin (14.4 μg/mL). The administration of ALE reduced the oedema formation in the carrageenan-induced rat paw oedema test, especially at dose of 500 mg/kg, the results being statistically significant and dose-dependent. Also, ALE showed statistically significant and dose-dependent antinociceptive effects in the acetic acid induced writhing test in mice and Randall Selitto test in rats. The results of the pharmacological experiments suggest that the anti-inflammatory and antinociceptive effects of the Arctium lappa extract (ALE) may be related to the ability of polyphenols such as chlorogenic acid to inhibit the synthesis and release of some pro-inflammatory mediators. Our experimental data justify the traditional use of this plant in the management of some inflammatory disease.

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Aralbaev, N. K. "A Note on the Kazakh Endemic Lappula zaissanica (Boraginaceae)." Novon 5, no. 2 (1995): 119. http://dx.doi.org/10.2307/3392229.

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Tejaswi, Juluri Krishna Dutta, Dr R. Govinda Rajan, and P. Sara. "Study of Hepatoprotective Activity of Saussurea Lappa Root Extract." International Journal of Trend in Scientific Research and Development Volume-2, Issue-6 (October 31, 2018): 55–60. http://dx.doi.org/10.31142/ijtsrd18390.

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Chhabra, B. R., S. Gupta, M. Jain, and P. S. Kalsi. "Sesquiterpene lactones from Saussurea lappa." Phytochemistry 49, no. 3 (October 1998): 801–4. http://dx.doi.org/10.1016/s0031-9422(97)00906-0.

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Gao, Haiyan, Guanglei Li, Junhe Zhang, and Jie Zeng. "Arctigenin: a lignan fromArctium lappa." Acta Crystallographica Section E Structure Reports Online 64, no. 8 (July 19, 2008): o1538. http://dx.doi.org/10.1107/s1600536808021752.

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Li, S., T. Y. An, J. Li, Q. Shen, F. C. Lou, and L. H. Hu. "PTP1B inhibitors from Saussrurea Lappa." Journal of Asian Natural Products Research 8, no. 3 (April 2006): 281–86. http://dx.doi.org/10.1080/10286020412331286434.

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Shoji, Noboru, Akemi Umeyama, Nobuaki Saito, Tsunematsu Takemoto, Akiko Kajiwara, and Yasushi Ohizumi. "Vasoactive Substances from Saussurea lappa." Journal of Natural Products 49, no. 6 (November 1986): 1112–13. http://dx.doi.org/10.1021/np50048a026.

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Ghedira, K., and P. Goetz. "Arctium lappa L. (Asteraceae) : Bardane." Phytothérapie 11, no. 6 (December 2013): 376–80. http://dx.doi.org/10.1007/s10298-013-0827-1.

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Wang, Fei, Zheng-Hong Xie, Yuan Gao, Yao Xu, Xue-Lian Cheng, and Ji-Kai Liu. "Sulfonated Guaianolides from Saussurea lappa." CHEMICAL & PHARMACEUTICAL BULLETIN 56, no. 6 (2008): 864–65. http://dx.doi.org/10.1248/cpb.56.864.

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Wiart, Christophe. "A note on Aucklandia lappa." International Immunopharmacology 15, no. 4 (April 2013): 789. http://dx.doi.org/10.1016/j.intimp.2013.03.003.

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Olennikov, D. N., L. M. Tankhaeva, and A. V. Rokhin. "Glucofructans from Saussurea lappa roots." Chemistry of Natural Compounds 47, no. 3 (July 2011): 339–42. http://dx.doi.org/10.1007/s10600-011-9927-z.

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Rollo, C. David, J. D. MacFarlane, and B. S. Smith. "Electrophoretic and allometric variation in burdock (Arctium spp.): hybridization and its ecological implications." Canadian Journal of Botany 63, no. 7 (July 1, 1985): 1255–61. http://dx.doi.org/10.1139/b85-173.

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Allometric variation and insect seed predation among Arctium minus, A. lappa, and two possible hybrids were quantified. All four biotypes were also examined using isoelectric focusing, and differences among their proteins were found for alkaline phosphatases, leucine amino peptidases, esterases, and peroxidases. The allometric and electrophoretic results indicated that hybridization between A. minus and A. lappa is very common. The implications for the population dynamics of Arctium are discussed. The parental species are probably maintained by the combined effects of differential insect predation on the seeds, differential dispersal of seeds, and reduced seed viability in hybrids.

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Wiedenfeld, Helmut, Amarsanaa B., Altanchirneg D., and Narantuya S. "Pvrrolizidine Alkaloid Containina Plants Used in Mongolian Traditional Medicine: Lappula Myosotis Moench." Scientia Pharmaceutica 73, no. 3 (September 30, 2005): 139–45. http://dx.doi.org/10.3797/scipharm.aut-05-12.

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Lappula myosotis Moench. (Boraginaceae) is a plant growing wide-spread in the Mongolian Aimags Khubsgul, Khangai, Khentei, Mongol dahurica, Altai and Alasha Gobi [1]. From this plant four pyrrolizidine alkloids were isolated and their structures determined using spectroscopical methods: lycopsamine, intermedine and their acetylderivatives. This plant is used in the Mongolian traditional medicine externally but on account of its high level of alkaloids (~ 0.2%) the usage of L. myosotis may be hazardous for humans.

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Nascimento, Bruno A. C., Luiz G. Gardinassi, Inaê M. G. Silveira, Marília G. Gallucci, Mariana A. Tomé, Júlia Fernanda D. Oliveira, Mirella R. A. Moreira, et al. "Arctium lappa Extract Suppresses Inflammation and Inhibits Melanoma Progression." Medicines 6, no. 3 (July 29, 2019): 81. http://dx.doi.org/10.3390/medicines6030081.

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Background: Arctium lappa has been used as popular medicinal herb and health supplement in Chinese societies. Bioactive components from A. lappa have attracted the attention of researchers due to their promising therapeutic effects. In this study, we investigated the effects of A. lappa hydroalcoholic extract (Alhe) during different models of inflammation, in vivo. Methods: The anti-inflammatory activity was evaluated through the air pouch model. For this, mice received an inflammatory stimulus with lipopolysaccharide (LPS) and were later injected with Alhe. To assess anti-tumoral activity, the animals were inoculated with B16F10 cells and injected with Alhe every 5 days, along the course of 30 days. Controls were submitted to the same conditions and injected with the vehicle. Peritoneal or air pouch fluids were collected to evaluate leukocyte counting or cellular activation via quantification of cytokines and nitric oxide. Results: Alhe injection reduced the neutrophil influx and production of inflammatory mediators in inflammatory foci after LPS or tumor challenges. Furthermore, Alhe injection reduced tumor growth and enhanced mice survival. Conclusions: Collectively, these data suggest that Alhe regulates immune cell migration and activation, which correlates with favorable outcome in mouse models of acute inflammation and melanoma progression.

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Predes, Fabrícia Souza, Sérgio Luis Pinto da Matta, Juliana Castro Monteiro, and Tânia Toledo de Oliveira. "Investigation of liver tissue and biochemical parameters of adult wistar rats treated with Arctium lappa L." Brazilian Archives of Biology and Technology 52, no. 2 (April 2009): 335–40. http://dx.doi.org/10.1590/s1516-89132009000200010.

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This study was carried out to evaluate the effects of Arctium lappa L. (burdock) on the liver of adult male Wistar rats as measured by light microscopy and biochemical parameters. The rats received the extract in water bottles at doses of 10 or 20 g/L daily for 40 days. There were no significant changes in the plasma levels of albumin, aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transferase (GGT), total protein, total cholesterol, urea, uric acid, triacylglycerol, calcium, phosphorus, chlorine and direct bilirubin. The morphological analysis did not reveal histopathological alterations in liver tissue. Both biochemical and morphological data did not indicate A. lappa toxicity.

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Baharuddin, Baharuddin. "PENERAPAN TEKNIK BRAINSTORMING TERHADAP KEMAMPUAN MENGAPRESIASI PUISI SISWA KELAS VI SD INPRES LAPPARA KECAMATAN TOMBOLO PAO KABUPATEN GOWA." KONFIKS : JURNAL BAHASA DAN SASTRA INDONESIA 4, no. 1 (June 19, 2017): 7. http://dx.doi.org/10.26618/jk.v4i1.1214.

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The purpose of this classroom action research is to know the ability of students to appreciate poetry through brainstorming technique which is expected to improve the process and the result of learning Indonesian especially poetry appreciation in grade 6 students of Inpres Lappara Elementary School with the number of subject as many as 24 people. The technique used in this research is a qualitative description. The class action research plan is implemented in two cycles. Each cycle has four stages: planning, implementation, observation, and reflection.The results of this class action research indicate that: (1) there is a positive change of activity in each cycle. (2) the average score increased according to the criteria: (theme 65 in cycle I increased to 68.83 in cycle II, 65.69 increase to 68.83, 66.63 note increased to 73.96, and mandate 67 , 79 increased to 72.54); (3) the average percentage of the ability to appreciate the increased poetry is related to the minimum completeness criterion that is small value of 65 (52,09% in cycle I decrease to 12,50%) and big value from 65 (47,915% increase to 87,50% ) shows a significant result.In accordance with the results of this PTK expressed significantly increased. Therefore, to grade 6 teachers of Inpres Lappara Elementary School, Tombolo Pao, Gowa District is expected to apply brainstorming technique to Indonesian language learning especially poetry appreciation.

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Cho, Kwang-Min, Xue-Hua An, Jae-Kwan Chon, Hyo-Sun Kim, and Jae-Chul Chun. "Foliage Contact Herbicidal Activity of Dehydrocostus lactone Derived from Saussurea lappa." Korean Journal of Weed Science 30, no. 4 (December 30, 2010): 421–28. http://dx.doi.org/10.5660/kjws.2010.30.4.421.

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Ramli, Muhammad, Syamsul Rijal, and Andi Ihsan. "The System of Supervision of the Management of the Fish Market in Lappa Sinjai Regency." Mediterranean Journal of Social Sciences 8, no. 1 (January 26, 2017): 403–9. http://dx.doi.org/10.5901/mjss.2017.v8n1p403.

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Abstract The aims of research were to review the supervisory management system, the determinant factors in the system of supervision of the management of fish market, as well as management strategies in improving supervision of fish market in Sinjai Regency. This study used a qualitative approach to techniques of data collection through interviews and in-depth study of the documentation. Formulation of the problem in this study were (i) How the system of supervision of the management of the fish market in Lappa Sinjai Regency? (ii) What is the determinant factor against the supervision management of fish market in Lappa Regency Sinjai? (iii) How the strategy of increased oversight of employee administration fish market in Sinjai Regency? The results of this study indicate that (i) the supervisory management system of fish market in Sinjai Regency, yet effective, this occurs because the implementation of the fish market service does not yet have an integrated surveillance system and its management do not involve private parties such as Village Units Economic Activities. The scrutiny has not shown optimal results due to the surveillance system management is not yet a professional, transparent and accountable so that efforts increased own-source revenue do not meet the expectations of the public. (ii) Factor determinants include the factor of human resources, the commitment of the apparatus, competence and leadership style. Salary/incentive factors, security, infrastructure and ecology as a factor in increasing the income supporting the own-source revenue through the levy management of fish market in Sinjai Regency. (iii) Improved Surveillance Strategies include implementation of Policies (Socialization), b. improving the quality of Implementing Retribution for example through education, c. Improve Infrastructure of Fish Market in Lappa Sinjai, and d. increased scrutiny by unit of fish market in Lappa and Dispenda Regency Sinjai.

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Yunusova, S. G. "Concentrates of polyunsaturated fatty acids from Lappula squarosa seed oil." Chemistry of Natural Compounds 49, no. 1 (March 2013): 85–87. http://dx.doi.org/10.1007/s10600-013-0512-5.

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Woo, Jeong-Hwa, Ji-Hye Ahn, Dae Sik Jang, and Jung-Hye Choi. "Effect of Dehydrocostus Lactone Isolated from the Roots of Aucklandia lappa on the Apoptosis of Endometriotic Cells and the Alternative Activation of Endometriosis-Associated Macrophages." American Journal of Chinese Medicine 47, no. 06 (January 2019): 1289–305. http://dx.doi.org/10.1142/s0192415x19500666.

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The roots of Aucklandia lappa have been used in traditional medicine in Asia to treat inflammation and diseases associated with pain, including endometriosis. The aim of this study was to investigate the anti-endometriotic effect of dehydrocostus lactone, an active compound in A. lappa roots, using human endometriotic cells and macrophages stimulated by these cells. Dehydrocostus lactone induced apoptotic cell death in 12Z human endometriotic cells. Dehydrocostus lactone stimulated the activation of caspase-3, -8, and -9, while caspase inhibitors significantly reversed the dehydrocostus lactone-induced cell death in 12Z cells. In addition, dehydrocostus lactone decreased the production of PGE2 and neurotrophins (BDNF, NGF, NT3, and NT4/5), which are regarded as endometriosis-associated pain factors in human endometriotic cells. Moreover, dehydrocostus lactone inhibited the expression of M2 markers (CD206, and Trem-2), IL-10, VEGF, and MMP-2/-9 in endometriosis-associated macrophages (EAMs). Furthermore, dehydrocostus lactone inhibited the Akt and NF[Formula: see text]B pathways in both endometriotic cells and EAMs. Taken together, our findings suggest that dehydrocostus lactone, an active compound of A, lappa, has anti-endometriotic activities via induction of apoptosis and downregulation of pain factors in endometriotic cells and inhibition of the alternative activation of EAMs.

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Tonea, Andrada, Mandra Badea, Liviu Oana, Sorina Sava, and Dan Vodnar. "Antibacterial and antifungal activity of endodontic intracanal medications." Medicine and Pharmacy Reports 90, no. 3 (July 25, 2017): 344–47. http://dx.doi.org/10.15386/cjmed-750.

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Background and aims. The sterilization of the entire root canal system represents the main goal of every endodontist, given the fact that the control of the microbial flora is the key point of every root canal treatment. The diversity of microorganisms found inside the root canal and also the resistance of some bacterial species to intracanal medications led to a continuous development of new endodontic products. The present study focuses on the comparison of the antibacterial and antifungal properties of different endodontic products, two commercially available, one experimental plant based extract, and two control substances.Methods. The disc diffusion assay was used to determine the antibacterial and antifungal properties of chlorhexidine, calcium hydroxide, a mix extract between Arctium lappa root powder and Aloe barbadensis Miller gel, Amoxicillin with clavulanic acid and Fluconazole (as control substances). Two of the most common microorganisms found in endodontic infections were chosen: Enterococcus faecalis (ATCC 29212) and Candida albicans ATCC(10231).Results. All tested substances showed inhibition zones around the discs, for Enterococcus faecalis and Candida albicans, including the experimental mix extract of Arctium lappa root powder with Aloe vera gel.Conclusion. The experimental mix extract of Arctium lappa root powder and Aloe vera gel is able to inhibit very resistant microorganisms, like Enterococcus faecalis and Candida albicans.

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Journal articles on the topic 'Lapprya'

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