Journal articles: 'Langmann'

1

Breucker, H. "Jan Langmann: Medizinische Embryologie." Andrologia 18, no. 1 (April 24, 2009): 96. http://dx.doi.org/10.1111/j.1439-0272.1986.tb01745.x.

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Draeger, J. "Kommentar zu Langmann et al." Klinische Monatsblätter für Augenheilkunde 221, no. 06 (September 21, 2005): 513–14. http://dx.doi.org/10.1055/s-2004-813287.

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Geddes, A. "Michael Langman." BMJ 348, jun02 8 (June 2, 2014): g3477. http://dx.doi.org/10.1136/bmj.g3477.

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4

Langman, Rodney. "Comment by Rodney Langman." Immunology Today 13, no. 10 (January 1992): 399–400. http://dx.doi.org/10.1016/0167-5699(92)90089-p.

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Louzoun, Y., E. Luning Prak, T. Friedman, S. Litwin, and M. Weigert. "Comment on Langman and Cohn." Seminars in Immunology 14, no. 3 (June 2002): 231–32. http://dx.doi.org/10.1016/s1044-5323(02)00048-9.

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6

Cohn, M. "Rodney Eric Langman: In Memoriam." Scandinavian Journal of Immunology 56, no. 6 (December 2002): 665–66. http://dx.doi.org/10.1046/j.1365-3083.2002.01185.x.

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7

Scialli, Anthony R. "Langman's medical embryology." Reproductive Toxicology 5, no. 4 (January 1991): 391–92. http://dx.doi.org/10.1016/0890-6238(91)90102-l.

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8

Sadler, T. W. "Langmanʼs Medical Embryology." Plastic and Reconstructive Surgery 81, no. 1 (January 1988): 131. http://dx.doi.org/10.1097/00006534-198801000-00024.

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9

Coleclough, C. "A Critique of the Cohn-Langman Protecton Theory." Immunological Reviews 115, no. 1 (June 1990): 173–81. http://dx.doi.org/10.1111/j.1600-065x.1990.tb00786.x.

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Bush, Elizabeth. "Guy Langman, Crime Scene Procrastinator (review)." Bulletin of the Center for Children's Books 65, no. 10 (2012): 500. http://dx.doi.org/10.1353/bcc.2012.0491.

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11

Wainwright, Susan. "Langmanʼs Medical Embryology. 11th Edition." Journal of Physical Therapy Education 24, no. 3 (2010): 81. http://dx.doi.org/10.1097/00001416-201007000-00014.

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12

Anstrom, John A. "Langman's medical embryology, 6th edition." Surgical Neurology 36, no. 1 (July 1991): 74–75. http://dx.doi.org/10.1016/0090-3019(91)90149-4.

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13

Blasi, Ivan, and Anna Bronovitskaya. "Dinamo Stadium, Moscow, 1927-1936, by Aleksandr Langman and Leonid Cherikover." Designing Modern Life, no. 46 (2012): 89. http://dx.doi.org/10.52200/46.a.u61ls8v3.

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In February 10, 2012 the demolition of the façade walls of the cultural heritage building of regional significance Dinamo Stadium got underway (Leningrandsky Prospect, 36). There is no need to prove the value of the building which was constructed in two stages in 1927-1936 upon the project of L. Cherikover and A. Langman. In 1987 the Stadium was placed under special protection of the state.

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14

Aldred, N. C. "Negotiating the Jacobean Printed Book. Ed. by PETE LANGMAN." Library 13, no. 3 (September 1, 2012): 345–47. http://dx.doi.org/10.1093/library/13.3.345.

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15

Barron, Bruce A. "C. Langman: Introduction to Vocational Rehabilitation: Policies, Practices and Skills." Journal of Occupational Rehabilitation 22, no. 2 (January 6, 2012): 282. http://dx.doi.org/10.1007/s10926-011-9350-0.

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16

Lutz, Kiki. "Benutzungsreglement für die Bestände des «Foto- & Familienarchivs Brown» im Museum Langmatt in Baden unter Berücksichtigung des normativen Umfelds." Informationswissenschaft: Theorie, Methode und Praxis 6, no. 1 (July 9, 2020): 186–208. http://dx.doi.org/10.18755/iw.2020.10.

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Die vorliegende Arbeit erstellt ein Benutzungsregelment für das private «Foto- & Familienarchiv Brown» im Museum Langmatt in Baden unter Berücksichtigung des geltenden normativen Umfelds. Dieses wird in einem ersten Teil in Bezug auf den Standort und die Rechtspersönlichkeit des Archivs ermittelt. In einem zweiten Schritt wird versucht, die Rechte und Interessen der Benutzenden, der im Archivgut mit Werken vertretenen Urheberinnen und der dokumentierten Personen soweit in Einklang zu bringen, dass innerhalb des Regelungsumfelds eine möglichst intensive und offene Nutzung stattfinden kann. Bei der Erstellung der Regelungen dienen die Benutzungsordnungen des Schweizerischen Bundesarchivs BAR und des Staatsarchivs des Kantons Aargau StAAG als Vergleichsfolien. Das resultierende Reglement kann das Ideal eines optimalen Interessensausgleichs aufgrund von faktischen Einschränkungen im Museum Langmatt letztlich nicht ganz erreichen. Die erarbeiteten Regelungen bieten zwar weitgehend Rechtssicherheit für Urheberinnen und dokumentierte Personen, jedoch nicht die grösstmögliche Freiheit bei der Nutzung des Archivguts, die unter rein rechtlichen Gesichtspunkten möglich wäre. Zwecks Implementierung des neuen Reglements im Museumsbetrieb wird ein internes Nutzungshandbuch für das Personal erstellt.

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17

Nagy, Z. A. "Evolutionary Origin of the Immune System: A Dialogue with Rod Langman." Scandinavian Journal of Immunology 67, no. 4 (April 2008): 313–21. http://dx.doi.org/10.1111/j.1365-3083.2008.02075.x.

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18

Srivastava, Geetanjali. "BOOK REVIEW: LANGMAN'S MEDICAL EMBRYOLOGY TH BY: T.W. SADLER. 13 EDITION." ERA'S JOURNAL OF MEDICAL RESEARCH 5, no. 1 (June 2018): 01. http://dx.doi.org/10.24041/ejmr2018.70.

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Kyono, Koichi. "The Precise Timing of Embryo Splitting for Monozygotic Dichorionic Diamniotic Twins: When Does Embryo Splitting for Monozygotic Dichorionic Diamniotic Twins Occur? Evidence for Splitting at the Morula/Blastocyst Stage From Studies of In Vitro Fertilization." Twin Research and Human Genetics 16, no. 4 (May 23, 2013): 827–32. http://dx.doi.org/10.1017/thg.2013.32.

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There is a long-held credo, as illustrated in Langman's Medical Embryology (11th ed., Sadler, 2010), that dichorionic diamniotic (DD) twins develop after embryo splitting in the early stages of embryonic development. However, from our clinical experiences of the examination of data from single-embryo transfers in 16 fertility clinics in Japan and from various reports, the majority of occurrences of DD twins have been found in the blastocyst stages.

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Of journal "Morphologia", Editorial office. "Langman's Medical Embryology. 14th Edition, 2018 Author: T.W. Sadler." Morphologia 13, no. 4 (December 27, 2019): 90–96. http://dx.doi.org/10.26641/1997-9665.2019.4.90-96.

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21

Bevis, Ruth. "Langman’s Medical Embryology, 6th edition T W Sadler Langman’s Medical Embryology, 6th edition Williams & Wilkins 412pp £20.50 0-683-07473-8." Paediatric Nursing 4, no. 3 (April 1992): 14. http://dx.doi.org/10.7748/paed.4.3.14.s14.

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Journal "Morphologia", Editorial office. "Review Langman's Medical Embryology / 13th edition. – LWW, 2014. – 424 p." Morphologia 9, no. 2 (June 29, 2015): 107–8. http://dx.doi.org/10.26641/1997-9665.2015.2.107-108.

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23

Pawlowski, Thomas. "Bernd Langmack: Was von der Zeche bleibt – Bilder nach der Kohle." Das Historisch-Politische Buch: Volume 66, Issue 4 66, no. 4 (December 1, 2018): 595–96. http://dx.doi.org/10.3790/hpb.66.4.595b.

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24

Roberts, Alun. "Charles Langmaid (1913–97): The travels of a young ship's surgeon." Journal of Medical Biography 18, no. 2 (May 2010): 81–87. http://dx.doi.org/10.1258/jmb.2009.009097.

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25

González, George. "Lauren Langman and George Lundskow, God, Guns, Gold and Glory—American Character and its Discontents." Critical Research on Religion 5, no. 3 (September 21, 2017): 327–32. http://dx.doi.org/10.1177/2050303217732138.

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26

Lopatko, Olga V., Sandra Orgeig, Christopher B. Daniels, and David Palmer. "Alterations in the surface properties of lung surfactant in the torpid marsupial Sminthopsis crassicaudata." Journal of Applied Physiology 84, no. 1 (January 1, 1998): 146–56. http://dx.doi.org/10.1152/jappl.1998.84.1.146.

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Lopatko, Olga V., Sandra Orgeig, Christopher B. Daniels, and David Palmer. Alterations in the surface properties of lung surfactant in the torpid marsupial Sminthopsis crassicaudata. J. Appl. Physiol. 84(1): 146–156, 1998.—Torpor changes the composition of pulmonary surfactant (PS) in the dunnart Sminthopsis crassicaudata [C. Langman, S. Orgeig, and C. B. Daniels. Am. J. Physiol. 271 ( Regulatory Integrative Comp. Physiol. 40): R437–R445, 1996]. Here we investigated the surface activity of PS in vitro. Five micrograms of phospholipid per centimeter squared surface area of whole lavage (from mice or from warm-active, 4-, or 8-h torpid dunnarts) were applied dropwise onto the subphase of a Wilhelmy-Langmuir balance at 20°C and stabilized for 20 min. After 4 h of torpor, the adsorption rate increased, and equilibrium surface tension (STeq), minimal surface tension (STmin), and the %area compression required to achieve STmin decreased, compared with the warm-active group. After 8 h of torpor, STmin decreased [from 5.2 ± 0.3 to 4.1 ± 0.3 (SE) mN/m]; %area compression required to achieve STmindecreased (from 43.4 ± 1.0 to 27.4 ± 0.8); the rate of adsorption decreased; and STeqincreased (from 26.3 ± 0.5 to 38.6 ± 1.3 mN/m). ST-area isotherms of warm-active dunnarts and mice at 20°C had a shoulder on compression and a plateau on expansion. These disappeared on the isotherms of torpid dunnarts. Samples of whole lavage (from warm-active and 8-h torpor groups) containing 100 μg phospholipid/ml were studied by using a captive-bubble surfactometer at 37°C. After 8 h of torpor, STmin increased (from 6.4 ± 0.3 to 9.1 ± 0.3 mN/m) and %area compression decreased in the 2nd (from 88.6 ± 1.7 to 82.1 ± 2.0) and 3rd (from 89.1 ± 0.8 to 84.9 ± 1.8) compression-expansion cycles, compared with warm-active dunnarts. ST-area isotherms of warm-active dunnarts at 37°C did not have a shoulder on compression. This shoulder appeared on the isotherms of torpid dunnarts. In conclusion, there is a strong correlation between in vitro changes in surface activity and in vivo changes in lipid composition of PS during torpor, although static lung compliance remained unchanged (see Langman et al. cited above). Surfactant from torpid animals is more active at 20°C and less active at 37°C than that of warm-active animals, which may represent a respiratory adaptation to low body temperatures of torpid dunnarts.

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CONFORD, PHILIP. "‘Somewhere Quite Different’: The Seventies Generation of Organic Activists and their Context." Rural History 19, no. 2 (October 2008): 217–34. http://dx.doi.org/10.1017/s0956793308002501.

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AbstractThis paper takes as its starting-point different perspectives on the organic movement's history since the 1940s. It identifies the polarised views of those who see a linear continuity in its development and of others who claim that a new generation of ‘counter-urbanites’ in the 1970s introduced an entirely distinct element. Drawing on recorded interviews with several of the leading figures in the seventies generation, the article argues that this generation was not as independent of its forebears as some of its members have claimed. It also throws light on the experiences of those who were inspired by the ‘self-sufficiency’ philosophy of John Seymour. The Steinerian Bio-Dynamic movement is identified as an important thread of continuity, as is the role played by two long-lived organic farmers, Dinah Williams and Mary Langman. While the seventies generation indeed affected the organic movement's direction from the 1970s onward, particularly through the Organic Growers Association, the case for a complete disjunction between different phases of organic history remains inadequate.

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Habicht, Gail S. "The Immune System. Evolutionary Principles Guide Our Understanding of this Complex Biological Defense System. Rodney E. Langman." Quarterly Review of Biology 65, no. 2 (June 1990): 259–60. http://dx.doi.org/10.1086/416815.

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Efroni, Sol, and Irun R. Cohen. "Simplicity belies a complex system: a response to the minimal model of immunity of Langman and Cohn." Cellular Immunology 216, no. 1-2 (March 2002): 23–30. http://dx.doi.org/10.1016/s0008-8749(02)00504-x.

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Reynaud, C. A., and J. C. Weill. "A few comments about the Conn and Langman theory of the ontogeny of the chicken humoral immune system." Research in Immunology 144, no. 6-7 (January 1993): 464–65. http://dx.doi.org/10.1016/0923-2494(93)80139-p.

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Yu, Hai Yan, Bo Gao, Yi Hao, Bo Wang, Guang Zhu Li, and Shi Wen Bi. "Research on Mechanism of Polymer Inhibiting Secondary Reaction in Clinker Leaching Process." Advanced Materials Research 189-193 (February 2011): 1242–47. http://dx.doi.org/10.4028/www.scientific.net/amr.189-193.1242.

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In this paper, the mechanism of polymer inhibiting secondary reaction in clinker leaching process was studied by IR spectrum of leaching residue obtained from the reaction of dicalcium silicate with sodium aluminate solution and the adsorption law of polymer AY and PEG on the surface of dicalcium silicate. The results indicated that the main adsorption mode of polymer AY and PEG were chemisorptions and physical adsorption respectively. The mechanism of decreasing the occurrence of secondary reaction is encapsulating surface of dicalcium silicate by AY and PEG. The adsorption mode of polymer AY on dicalcium silicate particles was single molecule adsorption and its adsorption isotherm was the typical “L” type. It accorded with Langmuin equation, and the adsorption free energy EAY was 57.89kJ.mol-1. The adsorption mode of polymer PEG on dicalcium silicate particles was multimolecular adsorption and its adsorption isotherm was the typical “S” type. It accorded with Freundlich equation and the adsorption free energy EPEG was 1.63kJ.mol-1.

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Berts, Ruth. "Langman’s medical embryologyLangman’s medical embryology 6th edition T WSadler Williams & Wilkins412pp£20.500-683-07473-8." Nursing Standard 6, no. 32 (April 29, 1992): 48. http://dx.doi.org/10.7748/ns.6.32.48.s53.

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Kaufman, J., and J. Salomonsen. "What in the dickens is with these chickens? an only slightly silly response to the first draft of Langman and Cohn." Research in Immunology 144, no. 6-7 (January 1993): 495–502. http://dx.doi.org/10.1016/0923-2494(93)80154-q.

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Hooks, Adam G. "Pete Langman, ed. Negotiating the Jacobean Printed Book. Farnham: Ashgate Publishing Limited, 2011. xv +230 pp. $99.95. ISBN: 978–0–7546–6633–2." Renaissance Quarterly 65, no. 1 (2012): 282–84. http://dx.doi.org/10.1086/665899.

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35

Neumann, Farrah, and Matthew Kanwit. "Acquiring variable commands at home and abroad: Examining optatives and imperatives in L1 and L2 Spanish." Studies in Hispanic and Lusophone Linguistics 13, no. 1 (May 27, 2020): 79–113. http://dx.doi.org/10.1515/shll-2020-2025.

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AbstractSince many linguistic structures are variable (i. e. conveyed by multiple forms), building a second-language grammar critically involves developing sociolinguistic competence (Canale and Swain. 1980. Theoretical bases of communicative approaches to second language teaching and testing. Applied Linguistics 1(1). 1–47), including knowledge of contexts in which to use one form over another (Bayley and Langman. 2004. Variation in the group and the individual: Evidence from second language acquisition. International Review of Applied Linguistics in Language Teaching 42(4). 303–318). Consequently, researchers interested in such competence have increasingly analyzed the study-abroad context to gauge learners’ ability to approximate local norms following a stay abroad, due to the quality and quantity of input to which learners may gain access (Lafford. 2006. The effects of study abroad vs. classroom contexts on Spanish SLA: Old assumptions, new insights and future research directions. In Carol Klee & Timothy Face (eds.), Selected proceedings of the 7th conference on the acquisition of Spanish and Portuguese as first and second languages, 1–25. Somerville, MA: Cascadilla Proceedings Project). Nevertheless, the present study is the first to examine native or learner variation between imperative (e. g. ven ‘come’) and optative Spanish commands (e. g. que vengas ‘come’). We first performed a corpus analysis to determine the linguistic factors to manipulate in a contextualized task, which elicited commands from learners before and after four weeks abroad in Alcalá de Henares, Spain. Their overall rates of selection and predictive factors were compared to local native speakers (NSs) and a control group of at-home learners.Results revealed that the abroad learners more closely approached NS rates of selection following the stay abroad. Nonetheless, for both learner groups conditioning by independent variables only partially approximated the NS system, which was more complex than previously suggested.

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36

Islam, Md, John Ontoy, and Prasanta Subudhi. "Meta-Analysis of Quantitative Trait Loci Associated with Seedling-Stage Salt Tolerance in Rice (Oryza sativa L.)." Plants 8, no. 2 (January 29, 2019): 33. http://dx.doi.org/10.3390/plants8020033.

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Soil and water salinity is one of the major abiotic stresses that reduce growth and productivity in major food crops including rice. The lack of congruence of salt tolerance quantitative trait loci (QTLs) in multiple genetic backgrounds and multiple environments is a major hindrance for undertaking marker-assisted selection (MAS). A genome-wide meta-analysis of QTLs controlling seedling-stage salt tolerance was conducted in rice using QTL information from 12 studies. Using a consensus map, 11 meta-QTLs for three traits with smaller confidence intervals were localized on chromosomes 1 and 2. The phenotypic variance of 3 meta-QTLs was ≥20%. Based on phenotyping of 56 diverse genotypes and breeding lines, six salt-tolerant genotypes (Bharathy, I Kung Ban 4-2 Mutant, Langmanbi, Fatehpur 3, CT-329, and IARI 5823) were identified. The perusal of the meta-QTL regions revealed several candidate genes associated with salt-tolerance attributes. The lack of association between meta-QTL linked markers and the level of salt tolerance could be due to the low resolution of meta-QTL regions and the genetic complexity of salt tolerance. The meta-QTLs identified in this study will be useful not only for MAS and pyramiding, but will also accelerate the fine mapping and cloning of candidate genes associated with salt-tolerance mechanisms in rice.

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37

Feurstein, J., M. Behanova, J. Haschka, K. Roetzer, G. Uyanik, M. Witsch-Baumgartner, G. Schett, J. Zwerina, and R. Kocijan. "POS1137 IDENTIFYING ADULT HYPOPHOSPHATASIA IN THE RHEUMATOLOGY UNIT." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 848.1–848. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2787.

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Background:The most frequent manifestation in adult Hypophosphatasia (HPP) is musculoskeletal pain.1,2 The unspecific nature of its clinical presentation may prevent correct diagnosis.3Objectives:Identifying adult hypophosphatasia in the rheumatology unit.Methods:Over a period of 10 years 9,522 patients were screened in a rheumatological outpatient unit. Serum ALP levels ≤ 40 U/l were found in 524 patients. After screening for secondary causes, 73 patients were invited for clinical evaluation. Genetic testing was performed in 23 patients with suspected HPP. Logistic regression models were used to estimate the association of each clinical factor with HPP.Results:Mutations in the ALPL gene were observed in 57% of genetically screened patients. Arthralgia, fractures and pain were the leading symptoms in HPP patients. Chondrocalcinosis (OR 29.12; 95% CI 2.02-1593.52) and dental disease (OR 8.33; 95% CI 0.93-143.40) were associated with HPP independent of BMI. Onset of symptoms in HPP was at 35.1 (14.3) years, with a mean duration from symptoms to diagnosis of 14.4 (8.1) years. Bone mineral density (BMD) and trabecular bone score (TBS) as well as bone turnover markers were not indicative for HPP.Conclusion:HPP can mimic joint diseases.4 Thus, in patients with uncertain rheumatologic complaints and low ALP, HPP should be considered as potential diagnosis.References:[1]Durrough C, Colazo JM, Simmons J, et al. Characterization of physical, functional, and cognitive performance in 15 adults with hypophosphatasia. Bone 2021;142:115695.[2]Seefried L, Kishnani PS, Moseley S, et al. Pharmacodynamics of asfotase alfa in adults with pediatric-onset hypophosphatasia. Bone 2021;142:115664.[3]Högler W, Langman C, Gomes da Silva H, et al. Diagnostic delay is common among patients with hypophosphatasia: initial findings from a longitudinal, prospective, global registry. BMC musculoskeletal disorders 2019;20(1):80.[4]Seefried L, Dahir K, Petryk A, et al. Burden of Illness in Adults With Hypophosphatasia: Data From the Global Hypophosphatasia Patient Registry. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 2020;35(11):2171-78.Disclosure of Interests:None declared.

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Pradhan, S. K., D. K. Nayak, M. Guru, E. Pandit, Sujata Das, S. R. Barik, S. P. Mohanty, and A. Anandan. "Screening and classification of genotypes for seedling-stage chilling stress tolerance in rice and validation of the trait using SSR markers." Plant Genetic Resources 14, no. 3 (July 14, 2015): 173–82. http://dx.doi.org/10.1017/s1479262115000192.

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Low-temperature stress is an important factor affecting the growth and development of rice in temperate and high-elevation areas. In this study, 220 germplasm lines were used for screening of tolerant genotypes, validation of molecular markers and identification of robust markers for seedling-stage chilling stress tolerance to be used in marker-assisted breeding (MAS) programme. The temperature regimes imposed in the growth chamber simulated cold-stress injuries at the seedling stages of the germplasm lines. The genotypes were classified into six classes: those having susceptible genotypes were classified into moderately and highly susceptible types, while tolerant types into moderately tolerant, tolerant, highly tolerant and very highly tolerant classes. Genotypes namely Langma, Umleng-1 and Geetanjali showed survival up to 25 d, which were better than the positive check Kalinga-III surviving up to 20 d under chilling stress. Ten simple sequence repeat (SSR) markers were tested for differentiation of genotypes. Individual use of SSR markers like RM284, RM286, RM85, RM341 and RM5746 can be applied in MAS breeding including combination use of non-pair markers like RM284, RM239 and RM85, which was even better than the combined use of RM284 and RM85. However, combined use of all ten markers can most effectively be employed for cold tolerance through MAS breeding.

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Cerroni-Long, E. L. "Beyond Borders: Remaking Cultural Identities in the New East and Central Europe. Edited by Lazlo Kurti and Juliet Langman (1997) Boulder, CO, Westview Press. Reviewed by E. L. Cerroni-Long." Journal of Political Ecology 6, no. 1 (December 1, 1999): 75. http://dx.doi.org/10.2458/v6i1.21494.

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Wynn, Joan R. "Neighborhood Organizations and Inner-City Youth: Successful Programs, Current InitiativesUrban Sanctuaries: Neighborhood Organizations in the Lives and Futures of Inner-City Youth. Milbrey W. McLaughlin , Merita A. Irby , Juliet Langman." American Journal of Education 103, no. 2 (February 1995): 218–24. http://dx.doi.org/10.1086/444098.

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Rubin, Clinton T. "Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism.Murray J. Favus , Sylvia Christakos , Michael Kleerekoper , Elizabeth Shane , Robert F. Gagel , Craig B. Langman , Andrew F. Stewart , Michael P. Whyte." Quarterly Review of Biology 69, no. 4 (December 1994): 565–66. http://dx.doi.org/10.1086/418846.

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42

Musser, Charles. ": Three Books on Film Comedy . ; Romantic Comedy in Hollywood, from Lubitsch to Sturges . James Harvey. ; The Marx Brothers: A Bio-Bibliography . Wes D. Gehring. ; Encyclopedia of American Film Comedy . Larry Langman." Film Quarterly 41, no. 4 (July 1988): 32–33. http://dx.doi.org/10.1525/fq.1988.41.4.04a00090.

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Kennel, Stephen J. "Monoclonal Antibodies Show Potential Monoclonal Antibodies: Probes for the Study of Autoimmunity and Immunodeficiency Barton F. Haynes G. S. Eisenbarth Monoclonal Antibodies and Cancer Barbara D. Boss Rod Langman Ian Trowbridge R. Dulbecco." BioScience 35, no. 3 (March 1985): 198–99. http://dx.doi.org/10.2307/1309887.

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44

Bugajski, Janusz. "Beyond Borders: Remaking Cultural Identities in the New East and Central Europe. Ed. Lászlo Kürti and Juliet Langman. Boulder, Colo.: Westview Press, 1997. vii, 160 pp. Notes. Chronology. Index. Figures. Tables. $45.00, hard bound." Slavic Review 57, no. 2 (1998): 426–27. http://dx.doi.org/10.2307/2501858.

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Musser, Charles. "Review: Three Books on Film Comedy; Romantic Comedy in Hollywood, from Lubitsch to Sturges by James Harvey; The Marx Brothers: A Bio-Bibliography by Wes D. Gehring; Encyclopedia of American Film Comedy by Larry Langman." Film Quarterly 41, no. 4 (1988): 32–33. http://dx.doi.org/10.2307/1212567.

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Zbikowski, Lawrence M. "Schubert (Re)Inventions - Ensemble Palladino: Alberto Mesirca gui, Ursula Langmayr sop, Eric Lamb fl, Firmian Lermer vla, Martin Rummel vc - Paladino Music 58, 2015 (2 CDs: 133 minutes), $28." Nineteenth-Century Music Review 14, no. 2 (November 29, 2016): 271–74. http://dx.doi.org/10.1017/s1479409816000525.

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ORTH, K. H., and K. BECKER. "A review of: D.J. Bennet and J.R. Thomson, “The Elements of Nuclear Power”, 3rd Edition (Langman Scientific and Technical, co-published in the United States with John Wiley & Sons, New York, 1989), 289 pp., $39.95." Energy Sources 13, no. 3 (July 1991): 411–12. http://dx.doi.org/10.1080/00908319108956423.

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Valentine, David. "Two-Spirit People: Native American Gender Identity, Sexuality, and Spirituality. Sue-Ellen Jacobs , Wesley Thomas , Sabine LangMen as Women, Women as Men: Changing Gender in Native American Cultures. Sabine Lang." Signs: Journal of Women in Culture and Society 27, no. 1 (October 2001): 290–94. http://dx.doi.org/10.1086/495686.

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Flickinger, John, Jagmohan Singh, Yanki Yarman, Robert Carlson, Scott Waldman, and Adam Snook. "608 Immunodominant listeria epitopes compete with vaccine-directed cd8+ t-cell responses rescued by peptide-MHC stabilizing modifications." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (November 2020): A644. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0608.

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Abstract:

BackgroundThe Gram-positive bacterium Listeria monocytogenes (Lm) is a promising vector for cancer immunotherapy due to its ability to directly infect antigen-presenting cells, induce potent CD8+ T-cell immunity, and remodel immunosuppressive tumor microenvironments.1 Recent clinical trials have demonstrated safety and immunogenicity of Lm-based cancer vaccines in lung, cervical, pancreatic, and other cancers. In colorectal cancer, the transmembrane receptor guanylyl cyclase C (GUCY2C) is an emerging target for immunotherapy.2 Here, we examined the immunogenicity of a recombinant strain of Listeria monocytogenes secreting GUCY2C (Lm-GUCY2C). Surprisingly, Lm-GUCY2C vaccination induced robust Lm-specific CD8+ T-cell immunity but failed to prime GUCY2C-specific CD8+ T-cell responses. These studies explore the hypothesis that immunodominant Lm antigens suppress primary immunity to subdominant GUCY2C epitopes in Lm-GUCY2CMethodsLm-GUCY2C expresses the extracellular domain of mouse GUCY2C23-429 downstream of an ActA promoter integrated into the genome of the live, attenuated delta actA delta inlB Lm strain. Altered peptide ligands were designed based on NetMHCpan 4.0 peptide-MHC binding algorithms and similarly cloned into Lm. Peptide-MHC class I complex stability was quantified by FACS-based surface peptide-MHC dissociation on the TAP-deficient cell line, RMA-S H-2Kd.3In vivo efficacy studies employed IFNγ-ELISpot quantification of T-cell responses and tumor challenge studies with the CT26 colorectal cancer cell line. Adenovirus expressing GUCY2C was used as a positive control.2 4ResultsLm-GUCY2C vaccination of BALB/c mice generated Lm-specific CD8+ T-cell responses but an absence of GUCY2C-specific immunity. Peptide-MHC stability studies revealed poor stability of the dominant GUCY2C254-262 epitope complexed with H-2Kd compared to H-2Kd-restricted Lm epitopes derived from the LLO and p60 Lm antigens. Mutation of the GUCY2C254-262 peptide at critical anchoring residues for binding H-2Kd revealed that the altered peptide ligand with an F255Y mutation significantly improved the stability of the GUCY2C254-262-H-2Kd complex. Similarly, vaccination of mice with recombinant Lm-GUCY2C expressing the altered peptide ligand (Lm-GUCY2CF255Y) restored GUCY2C immunogenicity and antitumor immunity.ConclusionsImmunodominant Lm antigens may interfere with immune responses directed to the vaccine target antigen GUCY2C by competing with GUCY2C epitope for MHC class I binding and presentation. Moreover, use of a substituted GUCY2C -peptide ligand with enhanced peptide-MHC class I stability restored GUCY2C-specific immunity in the context of Lm-GUCY2C, an approach that can be translated to patients. Importantly, these studies also suggest that ongoing Lm-based vaccine development programs targeting a variety of antigens in other cancer types may be similarly limited by the immunodominance of Lm epitopes.AcknowledgementsThe authors thank Dr. Peter Lauer for providing the pPL2 integration vector used in cloning Lm-GUCY2C and Dr. Sean Murphy for providing the RMA-S H-2Kd cell line.Ethics ApprovalStudies were approved by the Thomas Jefferson University IACUC (Protocol # 01956).ReferencesFlickinger JC, Rodeck U, Snook AE. Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress. Vaccines (Basel) 2018;6. doi:10.3390/vaccines6030048.Snook AE, Baybutt TR, Xiang B, Abraham TS, Flickinger JC, Hyslop T, et al. Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients. J Immunother Cancer 2019;7:104. doi:10.1186/s40425-019-0576-2.Müllbacher A, Lobigs M, Kos FJ, Langman R. Alloreactive cytotoxic T-cell function, peptide nonspecific. Scand J Immunol 1999;49:563–9.Flickinger J. JC, Singh J, Carlson R, Leong E, Baybutt T, Barton J, et al. Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity. J Immunother Cancer 2020.

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Seamons, Dick. "Field Guide to the Birds of the Middle East97109R.F. Porter, S. Christensen, P. Schiermacker‐Hansen. Field Guide to the Birds of the Middle East. London: T. and A.D. Poyser 1996. 460 pp, ISBN: 0‐85661‐076‐3 £29.95 Illustrated by A. Birch, J. Gale, M. Langman and B. Small." Reference Reviews 11, no. 2 (February 1997): 27. http://dx.doi.org/10.1108/rr.1997.11.2.27.109.

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Journal articles on the topic 'Langmann'

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