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1

FUKAGAWA, Shuji, Yuichi YOSHIDA, Kazunori URABE, Tetsuya KOGA, Masutaka FURUE, Aiko SUMINOE, and Akinobu MATSUZAKI. "Langerhans Cell Histiocytosis." Nishi Nihon Hifuka 65, no. 3 (2003): 211–12. http://dx.doi.org/10.2336/nishinihonhifu.65.211.

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2

Haubrich, William S. "Langerhans of the Islets of Langerhans." Gastroenterology 129, no. 3 (September 2005): 783. http://dx.doi.org/10.1053/j.gastro.2005.07.037.

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3

Raica, Marius, and Anca Maria Cimpean. "Paul Langerhans." Acta medico-historica Adriatica 15, no. 1 (2017): 139–46. http://dx.doi.org/10.31952/amha.15.1.7.

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Devetnaesto stoljeće bilo je vrijeme prave revolucije u znanosti i medicini. U tom je stoljeću došlo do mnogih otkrića u medicini i biologiji, a mnoga od njih su se podudarala s primjenom mikroskopa (Hermann van Deijl) i uvođenjem standardne histološke tehnike (Paul Ehrlich). Glavne vrste tkiva i pojedinačne stanice karakterizirane su i izvorno klasificirane prije više od stotinu godina, iako je manje pozornosti bilo posvećeno njihovim osnovnim funkcijama. To je uglavnom bilo zbog modaliteta obrade uzoraka tkiva koja je omogućavala posebno detaljne deskriptivne studije. Ipak, primjećuju se neki pokušaji povezivanja strukture s funkcijom. Njemački znanstvenik Paul Langerhans, poznat po otkriću Langerhansovih otočića gušterače i Langerhansovih stanica u epidermisu, pokušao je promijeniti konvencionalnu sudbinu morfoloških istraživanja uvodeći već od početka svoje znanstvene karijere u svoja istraživanja funkcionalnu hipotezu koja se temelji na tradicionalnim mikroskopskim promatranjima. Paul Langerhans bio je složena ličnost druge polovice XIX. stoljeća ne samo u medicini nego i u drugim područjima biologije. U ovom radu predstavljen je njegov život i njegova istraživačka djelatnost ne samo zbog važnosti njegovih otkrića već i zbog gledišta koja su ta otkrića potaknula u neočekivanim područjima medicine i biologije.
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4

Corts, Magga. "Langerhans-Inseln." Deutsche Heilpraktiker-Zeitschrift 12, no. 01 (February 21, 2017): 61. http://dx.doi.org/10.1055/s-0037-1599814.

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5

Jolles, S. "Paul Langerhans." Journal of Clinical Pathology 55, no. 4 (April 1, 2002): 243. http://dx.doi.org/10.1136/jcp.55.4.243.

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6

Emile, Jean-François, Sylvie Fraitag, Michèle Leborgne, Yves de Prost, and Nicole Brousse. "Langerhans' cell histiocytosis cells are activated langerhans' cells." Journal of Pathology 174, no. 2 (October 1994): 71–76. http://dx.doi.org/10.1002/path.1711740202.

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7

Geissmann, Frederic, Yves Lepelletier, Sylvie Fraitag, Jenny Valladeau, Christine Bodemer, Marianne Debré, Michelle Leborgne, Sem Saeland, and Nicole Brousse. "Differentiation of Langerhans cells in Langerhans cell histiocytosis." Blood 97, no. 5 (March 1, 2001): 1241–48. http://dx.doi.org/10.1182/blood.v97.5.1241.

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Langerhans cell histiocytosis (LCH) consists of lesions composed of cells with a dendritic Langerhans cell (LC) phenotype. The clinical course of LCH ranges from spontaneous resolution to a chronic and sometimes lethal disease. We studied 25 patients with various clinical forms of the disease. In bone and chronic lesions, LCH cells had immature phenotype and function. They coexpressed LC antigens CD1a and Langerin together with monocyte antigens CD68 and CD14. Class II antigens were intracellular and LCH cells almost never expressed CD83 or CD86 or dendritic cell (DC)–Lamp, despite their CD40 expression. Consistently, LCH cells sorted from bone lesions (eosinophilic granuloma) poorly stimulated allogeneic T-cell proliferation in vitro. Strikingly, however, in vitro treatment with CD40L induced the expression of membrane class II and CD86 and strongly increased LCH cell allostimulatory activity to a level similar to that of mature DCs. Numerous interleukin-10–positive (IL-10+), Langerin−, and CD68+ macrophages were found within bone and lymph node lesions. In patients with self-healing and/or isolated cutaneous disease, LCH cells had a more mature phenotype. LCH cells were frequently CD14− and CD86+, and macrophages were rare or absent, as were IL-10–expressing cells. We conclude that LCH cells in the bone and/or chronic forms of the disease accumulate within the tissues in an immature state and that most probably result from extrinsic signals and may be induced to differentiate toward mature DCs after CD40 triggering. Drugs that enhance the in vivo maturation of these immature DCs, or that induce their death, may be of therapeutic benefit.
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8

THIERY M. "Paul Langerhans (1847-1888) en de eilandjes van Langerhans." Tijdschrift voor Geneeskunde 63, no. 5 (January 1, 2007): 211–13. http://dx.doi.org/10.2143/tvg.63.05.2000040.

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9

Yi, Wu, Wan-yuan Chen, Tian-xin Yang, Jian-ping Lan, and Wen-na Liang. "Langerhans cell sarcoma arising from antecedent langerhans cell histiocytosis." Medicine 98, no. 10 (March 2019): e14531. http://dx.doi.org/10.1097/md.0000000000014531.

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10

Yu, R. C., A. C. Chu, C. Chu, and L. Buluwela. "Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis." Lancet 343, no. 8900 (March 1994): 767–68. http://dx.doi.org/10.1016/s0140-6736(94)91842-2.

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11

Gorošová, A., E. Matalová, I. Kociánová, and F. Tichý. "Langerhans Cells in Feline Foetal Epidermis - Immunohistochemical Study of Spatial Distribution." Acta Veterinaria Brno 77, no. 3 (2008): 307–12. http://dx.doi.org/10.2754/avb200877030307.

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Langerhans cells belong to the skin-associated lymphatic tissue (SALT). They are antigenpresenting cells derived from monocyte precursors in the bone marrow. The distribution of Langerhans cells was investigated in feline foetuses on day 40 of ontogenesis, in 9 selected body regions: regio intermandibularis, regio axilaris, regio prepubica, regio inguinalis, regio parietalis, regio interdigitalis, regio thoracis, regio sacralis and regio caudalis. Mouse monoclonal antibody against CD1 receptor (epitope CD1a) was applied to localize Langerhans cells in the skin samples. The highest number of Langerhans cells was found in biopsy of the dorsal part of the feline foetuses. Langerhans cells were present particularly among keratinocytes of stratum germinativum (stratum basale and stratum spinosum), scattered or clustered among epidermal cells closing the hair canal in the region close to the hair follicle. Langerhans cells were further located among cells of outer root sheath in the region of hair follicle infundibulum close to ostium of sebaceous glands ductus, some were found also in the upper part of the hair follicle isthmus. Langerhans cells seem to participate in skin disorders related to hypersensitivity and even tumour transformations. Distribution of these cells may play a role in disease predispositions; knowledge of the physiology and pathophysiology of Langerhans cells opens possible targeted treatments in veterinary medicine.
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12

Singh, Rasika, Charles Edward Keen, Christopher Stone, and Patrick Sarsfield. "Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion." Case Reports in Pathology 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/9842605.

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Langerhans cells are antigen presenting dendritic cells and tumours arising from these are rare. The tumours arising from these dendritic cells are divided into two categories according to a WHO classification: Langerhans cell histiocytosis and Langerhans cell sarcoma. It is the degree of atypia and clinical aggressiveness that distinguishes the two subtypes. Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells which can occur in skin, bone marrow, lymph nodes, spleen, liver, and lung. LCS can present with multiple cutaneous and systemic lesions. We present a case of Langerhans cell sarcoma with a unique morphological appearance and variable immunohistochemical profile within a single cutaneous lesion. LCS is a rare malignancy and its diagnosis is based on morphology, immunophenotypical examination, and ultrastructural analysis by electron microscopy. Our case highlights a unique morphological description of LCS wherein the pleomorphic neoplastic cells show epidermotropism and are surrounded by a variable amount of inflammatory infiltrate within a single cutaneous lesion. A single cutaneous lesion of Langerhans cell sarcoma with variable immunohistochemical profile has not been described so far.
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13

Menon, AnilS, and Manish Kumar. "Langerhans cell histiocytosis." Indian Journal of Medical Research 148, no. 3 (2018): 351. http://dx.doi.org/10.4103/ijmr.ijmr_1988_16.

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14

Pushpalatha, G., Prashanthy, DR Aruna, and Sushma Galgali. "Langerhans cell histiocytosis." Journal of Indian Society of Periodontology 15, no. 3 (2011): 276. http://dx.doi.org/10.4103/0972-124x.85675.

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15

Chauffaille, Maria de Lourdes L. F., Rosana M. Valério, Cybelle Maria Costa Diniz, Milvia Maria Simões, Silva Enokihara, Nylceo Michalany, Karin Ventura Ferreira, et al. "Langerhans cell histiocytosis." Sao Paulo Medical Journal 116, no. 1 (February 1998): 1625–28. http://dx.doi.org/10.1590/s1516-31801998000100006.

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The authors present a rare case of Langerhans cell histiocytosis in a 31 year old female patient with vulvar, peri-anal and oral lesions, diabetes insipidus, pulmonary skin and bone infiltrations. Skin biopsy immunohistochemistry presented positive S100 protein and vimentine, but the diagnosis was done with the demonstration of Birbeck granules with eletronic mucroscopy. The treatment was based on systemical chemotherapy although vulvar lesion has a bad response to chemotherapy.
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16

Jayachandran, S., and N. Balaji. "Langerhans Cell Histiocytosis." World Journal of Dentistry 2, no. 1 (2011): 57–62. http://dx.doi.org/10.5005/jp-journals-10015-1055.

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ABSTRACT Langerhans cell histiocytosis (LCH) is rare unique disorder of the reticuloendothelial system characterized by an abnormal proliferation of histiocytes and eosinophilic leukocytes. Lichtenstein gave the term Histiocytosis X in 1953 to include three clinical varieties; Eosinophilic granuloma, Hand-Schüller-Christian disease and Letterer-Siwe disease, which shared some common histologic features and clinical findings. In 1973, the term LCH was introduced as an alternative to histiocytosis X. LCH may manifest orally with single or multiple lesions of the alveolar or basal bone, ulcerated mucosal lesions accompanied by adenopathies and/or periodontal lesions, presenting gingival inflammation, bleeding, recession, necrosis, mobility of teeth and premature loss of teeth. Herewith, we report a case of LCH in a 45-year-old male with a characteristic oral and radiological findings. The purpose of this case report is to highlight the unique and rare presentation of oral and multiple skeletal involvement of Langerhans cell histiocytosis.
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17

Kontakis, George M., Zacharias Christoforakis, and Pavlos G. Katonis. "Langerhans Cell Histiocytosis." Orthopedics 30, no. 8 (August 1, 2007): 672–75. http://dx.doi.org/10.3928/01477447-20070801-11.

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18

Voitkovskaya, K. S., and A. L. Chernyaev. "Langerhans' cell histiocytosis." Russian Pulmonology, no. 1 (January 1, 2013): 90–94. http://dx.doi.org/10.18093/0869-0189-2013-0-1-90-94.

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19

Devine, J. C., and L. McWilliam. "Langerhans' cell histiocytosis." British Journal of Oral and Maxillofacial Surgery 36, no. 4 (August 1998): 318. http://dx.doi.org/10.1016/s0266-4356(98)90729-x.

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20

Leahy, Maureen A., Sylvia L. Brice, and William L. Weston. "Langerhans' cell histiocytosis." Current Problems in Dermatology 6, no. 1 (January 1994): 3–25. http://dx.doi.org/10.1016/s1040-0486(05)80007-9.

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21

FAZIO, N., L. SPAGGIARI, G. PELOSI, F. PRESICCI, and L. PREDA. "Langerhans' cell histiocytosis." Lancet 365, no. 9459 (February 18, 2005): 598. http://dx.doi.org/10.1016/s0140-6736(05)70802-3.

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22

Balar, HasmukhR, ArpitaJ Nishal, and JignaP Modi. "Langerhans cell histiocytosis." Indian Journal of Otology 19, no. 4 (2013): 194. http://dx.doi.org/10.4103/0971-7749.124517.

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23

Laliena Aznar, Sara, Cristina Martínez Faci, Laura Murillo Sanjuan, and Carmen Rodríguez-Vigil Iturrate. "Langerhans cell histiocytosis." Medicina Clínica (English Edition) 148, no. 10 (May 2017): e57. http://dx.doi.org/10.1016/j.medcle.2017.04.028.

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24

Thomas, C., J. F. Émile, and J. Donadieu. "Histiocitosis de Langerhans." EMC - Pediatría 42, no. 3 (January 2007): 1–8. http://dx.doi.org/10.1016/s1245-1789(07)70245-7.

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25

Montalli, Victor Angelo M., Regina Maria Holanda De Mendonça, César Alvarenga, Luciana Butini, Paulo De Camargo Moraes, Alfio José Tincani, and Vera Cavalcanti De Araujo. "Langerhans Cell Histiocytosis." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 126, no. 3 (September 2018): e44. http://dx.doi.org/10.1016/j.oooo.2018.02.046.

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26

DA ROCHA VIEIRA, RÚBIA, KARINE RASERA, and PAULA LUCE BOHRER. "LANGERHANS CELL HISTIOCYTOSIS." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 129, no. 1 (January 2020): e85. http://dx.doi.org/10.1016/j.oooo.2019.06.349.

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27

Brunning, Richard D. "Langerhans cell histiocytosis." British Journal of Haematology 111, no. 3 (December 2000): 717. http://dx.doi.org/10.1046/j.1365-2141.2000.02535.x.

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28

Pinkus, Geraldine S., Mark A. Lones, Fumio Matsumura, Shigeko Yamashiro, Jonathan W. Said, and Jack L. Pinkus. "Langerhans Cell Histiocytosis." American Journal of Clinical Pathology 118, no. 3 (September 2002): 335–43. http://dx.doi.org/10.1309/n2tw-enrb-1n1c-dwl0.

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29

Margo, Curtis E., and Darin R. Goldman. "Langerhans Cell Histiocytosis." Survey of Ophthalmology 53, no. 4 (July 2008): 332–58. http://dx.doi.org/10.1016/j.survophthal.2008.04.007.

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30

BREATHNACH, S. M. "The Langerhans cell." British Journal of Dermatology 119, no. 4 (October 1988): 463–69. http://dx.doi.org/10.1111/j.1365-2133.1988.tb03249.x.

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31

Giovannetti, Filippo, Ikenna Valentine Aboh, Glauco Chisci, Paolo Gennaro, Guido Gabriele, Flavia Cascino, Paolo Di Curzio, and Giorgio Iannetti. "Langerhans Cell Histiocytosis." Journal of Craniofacial Surgery 25, no. 3 (May 2014): 1134–36. http://dx.doi.org/10.1097/scs.0000000000000668.

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32

Park, Ligaya, Clayton Schiltz, and Neil Korman. "Langerhans Cell Histiocytosis." Journal of Cutaneous Medicine and Surgery 16, no. 1 (January 2012): 45–49. http://dx.doi.org/10.1177/120347541201600109.

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Background: The cutaneous presentation of Langerhans cell histiocytosis (LCH) is very rare and can be highly variable among individuals, which can often lead to a delay in diagnosis. Objective: To discuss a case report and literature review of important clinical indicators, histology, diagnosis, evaluation, and treatment guidelines. Methods: Case report and literature review. Results: Skin biopsies positive for CD1a and/or langerin are diagnostic for LCH. A thorough review of systems, baseline laboratory tests, and imaging studies can determine the extent of LCH. Treatment of cutaneous disease is largely based on case report and small case studies, but baseline treatment should generally begin with oral or topical steroids. When patients have more severe disease that requires a systemic approach, the efficacy of therapy should be assessed 6 weeks into therapy, with subsequent treatment intensification in patients with limited response. Conclusion: Owing to the rarity of this condition, there are no specific guidelines for treatment of LCH, but guidelines put forth by the Histiocyte Society assist in categorization and basic treatment approaches for patients with systemic disease.
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33

Fazio, Nicola, Lorenzo Spaggiari, Giuseppe Pelosi, Fabio Presicci, and Lorenzo Preda. "Langerhans' cell histiocytosis." Lancet 365, no. 9459 (February 2005): 598. http://dx.doi.org/10.1016/s0140-6736(05)17910-0.

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34

Cleveland, Deborah B., Kenneth M. Goldberg, John S. Greenspan, Todd E. Seitz, and Arthur S. Miller. "Langerhans' cell histiocytosis." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 82, no. 5 (November 1996): 541–48. http://dx.doi.org/10.1016/s1079-2104(96)80201-0.

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35

Paller, Amy S. "Langerhans cell histiocytosis." Journal of the American Academy of Dermatology 35, no. 3 (September 1996): 457. http://dx.doi.org/10.1016/s0190-9622(96)90624-6.

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36

Ruco, Luigi P., Stefania Uccini, and Carlo D. Baroni. "The Langerhans' cells." Allergy 44, s9 (January 1989): 27–30. http://dx.doi.org/10.1111/j.1398-9995.1989.tb02451.x.

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37

RUCO, LUIGI P., STEFANIA UCCINI, and CARLO D. BARONI. "The Langerhans? cells." Allergy 44, s9 (January 1989): 27–30. http://dx.doi.org/10.1111/j.1398-9995.1989.tb04312.x.

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38

Thomas, C., and J. Donadieu. "Histiocitosis de Langerhans." EMC - Aparato Locomotor 46, no. 4 (December 2013): 1–8. http://dx.doi.org/10.1016/s1286-935x(13)65926-2.

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39

Egeler, R. Maarten, and Giulio J. D'Angio. "Langerhans cell histiocytosis." Journal of Pediatrics 127, no. 1 (July 1995): 1–11. http://dx.doi.org/10.1016/s0022-3476(95)70248-2.

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40

Munthe, Bulan Ginting. "Histiositosis Sel Langerhans." Sari Pediatri 4, no. 1 (December 6, 2016): 13. http://dx.doi.org/10.14238/sp4.1.2002.13-20.

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Histiositosis sel Langerhans (HSL) adalah penyakit akibat proliferasi sel Langerhans diberbagai jaringan organ. Penyakit ini mempunyai gejala klinis yang bervariasi menyerupaipenyakit lain sehingga diagnosisnya menjadi sulit. Sampai saat ini penyebabnya secarapasti belum diketahui, terakhir diketahui lesi pada penyakit ini menunjukkan klonalitas.Diagnosis ditegakkan berdasarkan kriteria The Histiocyte Society yaitu presumptive,designated dan definitive HSL jika pada pemeriksaan mikroskop elektron ditemukangranula Birbeck. Tatalaksana penyakit ini tergantung pada jumlah sistem organ yangterlibat. Bila melibatkan multisistem pada umumnya menggunakan rejimen prednisolon,vinblastin dan etoposid dengan dosis dan jangka waktu yang berbeda-beda karena belumada rejimen baku. Prognosis dipengaruhi oleh usia, disfungsi organ dan respons terhadappengobatan.
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41

Lampert, Fritz. "LANGERHANS CELL HISTIOCYTOSIS." Hematology/Oncology Clinics of North America 12, no. 2 (April 1998): 213–19. http://dx.doi.org/10.1016/s0889-8588(05)70506-2.

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42

Leonidas, John C., Mark Guelfguat, and Elsa Valderrama. "Langerhans' cell histiocytosis." Lancet 361, no. 9365 (April 2003): 1293–95. http://dx.doi.org/10.1016/s0140-6736(03)12990-x.

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43

&NA;. "Langerhans’ Cell Sarcoma." American Journal of Dermatopathology 26, no. 2 (April 2004): 137. http://dx.doi.org/10.1097/00000372-200404000-00017.

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44

Mehta, Bhakti, and Rajkumar Venkatramani. "Langerhans'-Cell Histiocytosis." New England Journal of Medicine 371, no. 11 (September 11, 2014): 1050. http://dx.doi.org/10.1056/nejmicm1312532.

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45

Chu, Tony. "Langerhans cell histiocytosis." Australasian Journal of Dermatology 42, no. 4 (November 2001): 237–42. http://dx.doi.org/10.1046/j.1440-0960.2001.00527.x.

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46

Ladisch, Stephan. "Langerhans cell histiocytosis." Current Opinion in Hematology 5, no. 1 (January 1998): 54–58. http://dx.doi.org/10.1097/00062752-199801000-00010.

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47

Caldemeyer, Karen S., Edwin T. Parks, and Ginat W. Mirowski. "Langerhans cell histiocytosis." Journal of the American Academy of Dermatology 44, no. 3 (March 2001): 509–11. http://dx.doi.org/10.1067/mjd.2001.109304.

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48

Cumberbatch, M., R. J. Dearman, C. E. M. Griffiths, and I. Kimber. "Langerhans cell migration." Clinical and Experimental Dermatology 25, no. 5 (September 2000): 413–18. http://dx.doi.org/10.1046/j.1365-2230.2000.00678.x.

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49

Howarth, Douglas M., Gerald S. Gilchrist, Brian P. Mullan, Gregory A. Wiseman, John H. Edmonson, and Paula J. Schomberg. "Langerhans cell histiocytosis." Cancer 85, no. 10 (May 15, 1999): 2278–90. http://dx.doi.org/10.1002/(sici)1097-0142(19990515)85:10<2278::aid-cncr25>3.0.co;2-u.

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50

Ferringer, Tammie, Peter M. Banks, and John S. Metcalf. "Langerhans Cell Sarcoma." American Journal of Dermatopathology 28, no. 1 (February 2006): 36–39. http://dx.doi.org/10.1097/01.dad.0000146314.52378.c2.

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