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1

Wender, Regina. Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter. [Baltimore, MD]: Society for Neuroscience, 2000.

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2

Ogliaruso, Michael A. Synthesis of lactones and lactams. Chichester: Wiley, 1993.

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3

Peter G. J. M. Janssen. Lactate threshold training. Champaign, IL: Human Kinetics, 2001.

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4

Janssen, Peter. Training lactate pulse rate. Oulu, Finland: Polar Electro Oy, 1989.

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5

Ruiz, Ricardo. Estación lactante. Torrejón de la Calzada: Devenir, 2006.

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6

Bonani, Gian Paolo. Maria lactans. Roma: Edizioni Marianum, 1995.

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7

Bonani, Giampaolo. Maria lactans. Roma: Edizioni Marianum, 1995.

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8

Banik, Bimal K., ed. Beta-Lactams. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55621-5.

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9

Boswell, Sophie. Comprendiendo a tu bebé. Barcelona: Paidós, 2007.

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10

Isis lactans-- Maria lactans: Untersuchungen zur koptischen Ikonographie. Altenberge: Oros Verlag, 1996.

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11

Huggins, Kathleen. El libro esencial para madres lactantes. 6th ed. Boston, Mass: Harvard Common Press, 2010.

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12

El libro esencial para madres lactantes. 6th ed. Boston, Mass: Harvard Common Press, 2010.

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13

The blood lactate response to exercise. Champaign, IL: Human Kinetics, 1995.

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14

Boyce, Julian. Lactate dehydrogenase isoenzymes in malignant serous effusions. [s.l: The Author], 1989.

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15

Beaudoin, Marc. Glucose, lactate and lactate dehydrogenase levels in the human kidney carcinoma cell line A498 (ATCC HTB-44). Sudbury, Ont: Laurentian University, 1993.

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16

Janecki, Tomasz, ed. Natural Lactones and Lactams. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527666911.

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17

Alcaide, B., and Bimal K. Banik. Heterocyclic scaffolds I: Ss-lactams. Heidelberg: Springer, 2010.

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18

Page, Michael I., ed. The Chemistry of β-Lactams. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2928-2.

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19

Lee, R. J. Lactic acid metabolism and lactate dehydrogenases of Vibrio species. Portsmouth: Portsmouth Polytechnic,School of Pharmacy..., 1987.

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20

Jones, Mark. The enzyme catalysed formation of lactams. Huddersfield: Polytechnic of Huddersfield, 1991.

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21

Ogliaruso, Michael A., and James F. Wolfe, eds. Synthesis of Lactones and Lactams (1993). Chichester, UK: John Wiley & Sons, Inc., 1993. http://dx.doi.org/10.1002/9780470772522.

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22

Muldoon, Lori. Glucose, lactate, and lactate dehydrogenase activity of the small cell lung cancer line H-209 and the drug resistant variant H-209/V6. Sudbury, Ont: Laurentian University, 1992.

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23

Ya eres mamá: La guía útil para el primer año de tu hijo. Barcelona, España: Planeta, 2009.

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24

Arthur, Greenberg, Breneman Curt M, and Liebman Joel F, eds. The amide linkage: Structural significance in chemistry, biochemistry, and materials science. Hoboken, NJ: Wiley-Interscience, 2003.

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25

I, Georg Gunda, ed. The Organic chemistry of b [beta]-lactams. New York, N.Y: VCH Publishers, 1992.

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26

Urajnik, Diana J. The effects of lactate oxidase on human MCF7 breast cancer cells. Sudbury, Ont: Laurentian University, 1998.

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27

Pinson, Claire. Bebé: Instructivo. México, D.F: Ediciones Larousse, 2006.

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28

Anderson, Owen. Lactate lift-off. SSS Pub, 1998.

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29

Sharpe, Cameron Saunders. Genetic and environmental variation in stress physiology among steelhead trout (Oncorhynchus mykiss). 1992.

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30

Sada, Nagisa, and Tsuyoshi Inoue. Lactate Dehydrogenase. Edited by Detlev Boison. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0029.

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Glucose is transported into neurons and used as an energy source. It is also transported into astrocytes, a type of glial cell, and converted to lactate, which is then released to neurons and used as another energy source. The latter is called the astrocyte-neuron lactate shuttle. Although the lactate shuttle is a metabolic pathway, it also plays important roles in neuronal activities and brain functions. We recently reported that this metabolic pathway is involved in the antiepileptic effects of the ketogenic diet. Lactate dehydrogenase (LDH) is a metabolic enzyme that mediates the lactate shuttle, and its inhibition hyperpolarizes neurons and suppresses seizures. This enzyme is also a molecular target of stiripentol, a clinically used antiepileptic drug for Dravet syndrome. This review provides an overview of electrical regulation by the astrocyte-neuron lactate shuttle, and then introduces LDH as a metabolic target against epilepsy.
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31

Chiappini, Cristina Huberman de. Observacion de Lactantes. Kargieman, 1997.

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32

Hqny, Unicef. Cómo la Comercialización de Los Preparados para Lactantes Influye en Nuestras Decisiones Sobre la Alimentación Del Lactante. United Nations Children's Fund, The (UNICEF), 2022.

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33

Peter, M. D. Janssen. Lactate Threshold Training. Human Kinetics Publishers, 2001.

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34

Training Lactate Pulse-Rate. Polar Electro, 1987.

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35

Gutierrez, Pedro. Homicidio y Lesiones En Lactantes. Fabian J. Di Placido Editor, 2006.

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36

Huggins, Kathleen. Libro Esencial para Madres Lactantes. Harvard Common Press, 2010.

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37

Koletzko, Berthold, ed. Atención nutricional de lactantes prematuros. S. Karger AG, 2022. http://dx.doi.org/10.1159/isbn.978-3-318-07142-9.

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38

Blokdijk, G. J. Sodium Lactate; A Complete Guide. CreateSpace Independent Publishing Platform, 2018.

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39

Jansen, Tim C., and Jan Bakker. Lactate monitoring in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0139.

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An increased blood lactate level (hyperlactataemia) is commonplace in critically-ill patients. Lactate is usually measured with the aim of detecting tissue hypoxia, but this is an oversimplification as aerobic processes can also result in increased levels. Understanding of the various anaerobic and aerobic mechanisms of production and clearance is essential for the correct interpretation of hyperlactataemia. Despite the broad differential diagnosis, hyperlactataemia generally predicts adverse outcomes. The consistency of its prognostic value emphasizes its place in the risk stratification of critically-ill patients. Lactate clearance was non-inferior to central venous oxygen saturation as a goal of early resuscitation in patients presenting to the emergency department with severe sepsis or septic shock. Therapy guidance by lactate monitoring significantly reduced hospital mortality in ICU patients admitted with hyperlactataemia after adjustment for predefined risk factors, a finding consistent with important secondary endpoints. These results confirm that lactate monitoring offers clinical benefit and should be incorporated within a goal-directed therapy strategy.
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40

Comprendiendo a Tu Bebe/ Understanding Your Baby (Nueva Clinica Tavistock/ New Tavistock Clinic). Paidos Iberica Ediciones S a, 2007.

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41

Jiang, Chang. Gender differences in peak blood lactate concentration and blood lactate removal following strenuous exercise. 1991.

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42

Chang, Jiang. Gender differences in peak blood lactate concentration and blood lactate removal following strenuous exercise. 1992.

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43

Gender differences in peak blood lactate concentration and blood lactate removal following strenuous exercise. 1991.

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44

Klein, Jerome O., Charles D. Blustone, and Charles D. Bluestone. Otitis Media En Lactantes y Ninos. Editorial Medica Panamericana, 2000.

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45

J, Weber, H. Denolin, P. R. Moret, and J. C. Haissly. Lactate: Physiologic, Methodologic and Pathologic Approach. Springer London, Limited, 2012.

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46

Page, M. I. Chemistry of -Lactams. Springer, 2012.

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47

ANCAP, Victoria. Memorias de un Lactante. Independently Published, 2019.

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48

María Alexandra De Paz Gago. Retinoblastoma en el Lactante. Universidad Complutense de Madrid, Servicio de Publicaciones, 2005.

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49

Casado, F. Ventilacion Mecanica En Recien Nacidos y Lactantes. Ergon Ediciones, 2004.

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50

Rani, Reshma. Lactate Dehydrogenase: Biochemistry, Function and Clinical Significance. Nova Science Publishers, Incorporated, 2019.

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