Dissertations / Theses on the topic 'Labyrinth (ear)'
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Adamska, Maja. "Nkx5 genes in inner ear development and genome evolution." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=96230459X.
Full textLi, Junchang, and 李俊畅. "Sox2 and inner ear development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/206990.
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Biochemistry
Master
Master of Philosophy
Hu, Zhengqing. "Investigating a cell replacement therapy in the inner ear /." Stockholm, 2004. http://diss.kib.ki.se/2005/91-7140-170-9/.
Full textZelenskaya, Alexandra. "Atomic force microscopic studies of inner ear structure and mechanics /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-021-4/.
Full textTang, Shiu-ping Anna. "Molecular developmental genetics of the inner ear mutant, yellow submarine (Ysb)." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B43895712.
Full textMak, Chi-yan Angel, and 麥志昕. "Bioinformatic and functional approaches to identify potential SOX9 target genes in inner ear development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hdl.handle.net/10722/193405.
Full textLiang, Guihua. "K⁺ channels in the inner ear : electrophysiological and molecular studies /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7349-971-4/.
Full textDuncan, Robert Keith. "Finite-element analysis of inner ear hair bundles : a parameter study of bundle mechanics /." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-09292009-020226/.
Full textLiu, Yuchen, and 刘雨辰. "The roles of Irx3 and Irx5 genes in mammalian inner ear development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/207900.
Full textpublished_or_final_version
Biochemistry
Master
Master of Philosophy
Tang, Shiu-ping Anna, and 鄧紹平. "Molecular developmental genetics of the inner ear mutant, yellow submarine (Ysb)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B43895712.
Full textPhillips, Kelli R. "Characterization of myosin I in the inner ear." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5140.
Full textTitle from document title page. Document formatted into pages; contains vii, 114 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
Patel, Nirmal Praful School of Medicine UNSW. "Olfactory progenitor cell transplantation into the mammalian inner ear." Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/26180.
Full textWong, Yee-man Elaine. "Analysis of abnormal craniofacial and ear development of a transgenic mutant with ectopic hoxb3 expression." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36875028.
Full textWong, Yee-man Elaine, and 王怡雯. "Analysis of abnormal craniofacial and ear development of a transgenic mutant with ectopic hoxb3 expression." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36875028.
Full textSansom, Andrew J., and n/a. "The role of calcium-dependent pathways in vestibular compensation." University of Otago. Department of Pharmacology & Toxicology, 2005. http://adt.otago.ac.nz./public/adt-NZDU20070418.145158.
Full textGliddon, C. M., and n/a. "An attempt to elucidate the role of GABAA receptors in vestibular compensation." University of Otago. Department of Pharmacology & Toxicology, 2006. http://adt.otago.ac.nz./public/adt-NZDU20070427.150754.
Full textChristison, Joseph George. "The role of bone morphogenetic proteins in otic specification /." Connect to title online (ProQuest), 2008. http://proquest.umi.com/pqdweb?did=1616787971&sid=1&Fmt=2&clientId=11238&RQT=309&VName=PQD.
Full textTypescript. Includes vita and abstract. Includes bibliographical references (leaves 43-47). Also available online in ProQuest, free to University of Oregon users.
Chu, Kit-hang, and 朱傑亨. "Study of abnormal inner ear development in Waardenburg-Shah syndrome using a Sox10-GEP mutant mouse model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hdl.handle.net/10722/206530.
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Biochemistry
Doctoral
Doctor of Philosophy
Kwong, Wai-hang. "Functional analyses on TGF?BMP signaling and type IIA procollagen in inner ear development." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43815601.
Full textKwong, Wai-hang, and 鄺偉恒. "Functional analyses on TGF{221}/BMP signaling and type IIA procollagenin inner ear development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43815601.
Full textWu, Min'er. "Mei ni ai bing ("er xuan yun") Zhong yi zhi liao de lin chuang wen xian yan jiu /." click here to view the abstract and table of contents, 2006. http://net3.hkbu.edu.hk/~libres/cgi-bin/thesisab.pl?pdf=b20009306a.pdf.
Full text吳敏兒. "梅尼埃病("耳眩暈")中醫治療的臨床文獻研究." HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/752.
Full textKamaid, Toth Andres. "BMP4 regulation of sensory organ development in the chick inner ear." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7137.
Full textThe specific aims proposed were:
1- Analyze the cellular effects caused by addition of BMP4 in a model of isolated chick otic vesicles in culture, measuring parameters of cell proliferation, cell death and sensory cell fate specification.
2- Analyze the cellular effects caused by inhibition of BMP4 signaling in a model of isolated chick otic vesicles in culture, measuring parameters of cell proliferation, cell death and sensory cell fate specification.
3- Analyze the expression in the innear ear of downstream targets of BMP signalling, in particular, analyse the members of Id gene family.
4- Analyze the regulation of Id genes by BMP signalling in the inner ear.
5- Analyze the expression of genes involved in the process of terminal differentiation, in particular, Btg1 and Btg2 genes
6- Analyze the regulation of Btg1 and Btg2 gene by BMP signalling in the inner ear
Biswas, Anindita. "Analysis of motor activity of recombinant myosin-1c." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5522.
Full textTitle from document title page. Document formatted into pages; contains xi, 82 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
Baumgart, Johannes. "The Hair Bundle: Fluid-Structure Interaction in the Inner Ear." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-63810.
Full textBei der Hörwahrnehmung eines Klangs spielen viele komplexe Prozesse zusammen. Der Schlüsselprozess, die Umwandlung mechanischer Schwingungsbewegung in elektrische Signale, findet in den Haarbündeln im Innenohr statt. Diese Haarbündel sind hoch entwickelte mechanosensitive Organellen, bestehend aus vielen nahe beieinander stehenden Stereozilien umgeben von Flüssigkeit. Die beträchtliche Viskosität dieser Flüssigkeit führt zur Energiedissipation und zur Schwingungsdämpfung, was im Gegensatz zur bekannten hohen Empfindlichkeit und der ausgezeichneten Frequenzselektivität der Hörwahrnehmung steht. Um die Komponenten des Haarbündelsystems in ihrem funktionalen Zusammenspiel besser zu verstehen, bedarf es eines wirklichkeitsgetreuen Modells unter Einbeziehung der Wechselwirkung zwischen Flüssigkeit und Struktur. Mit dieser Arbeit wird ein neuer Ansatz vorgestellt, um die Mechanik der Fluid-Struktur-Wechselwirkung im Innenohr zu analysieren. Da die Bewegungen bei der normalen Mechanotransduktion wesentlich kleiner als die geometrischen Abmessungen sind, ist es möglich, das Verhalten von Fluid und Struktur in Form der Verschiebungsvariable in einem linearen einheitlichen System von Gleichungen ausreichend genau zu beschreiben. Dieses System von partiellen Differentialgleichungen wird mit der Finite-Elemente-Methode gelöst. Basierend auf experimentell ermittelten Daten vom Haarbündel des Ochsenfrosches wird ein detailliertes Modell erstellt, welches sowohl die Interaktion mit der umgebenden Flüssigkeit als auch die koppelnde Flüssigkeit in den engen Spalten zwischen den einzelnen Stereozilien erfasst. Die experimentellen Daten sind Ergebnisse von hochauflösenden interferometrischen Messungen bei physiologisch relevanten Bewegungsamplituden im Bereich von unter einem Nanometer bis zu mehreren Dutzend Nanometern, sowie über einen breiten Frequenzbereich von einem Millihertz bis hundert Kilohertz. Das Modell erlaubt die Berechnung der auftretenden viskosen Widerstände aus der numerischen Analyse der verschiedenen beobachteten Bewegungsmoden. Es kann gezeigt werden, dass durch die Gruppierung zu einem Bündel der Gesamtwiderstand drastisch reduziert ist, im Vergleich zur Summe der Widerstände einzelner Stereozilien, die sich individuell und unabhängig voneinander bewegen. Die einzelnen Stereozilien in einem Haarbündel sind durch elastische Strukturen mechanisch miteinander verbunden: Die Energie des Schalls wird durch schräg angeordnete sogenannte Tiplinks auf die mechanotransduktiven Kanäle übertragen, wohingegen horizontale Querverbindungen die Stereozilien direkt koppeln. Während der Haarbündelauslenkung verursachen die Tiplinks zusätzlichen Widerstand durch stark dissipative Relativbewegungen zwischen den Stereozilien. Die horizontalen Querverbindungen unterdrücken diese Bewegungen und sind dafür verantwortlich, dass sich das Haarbündel als Einheit bewegt und der Gesamtwiderstand gering bleibt. Die Steifigkeit der Stereozilien und der Verbindungselemente sowie deren Geometrie sind in dem Modell sorgfältig angepasst, um eine Übereinstimmung mit den Beobachtungen aus verschiedenen Experimenten zu erzielen. Als Referenz dienen Steifigkeits- und Widerstandsmessungen, sowie Kohärenzmessungen für die gegenüberliegenden Außenkanten des Bündels, die jeweils mit und ohne Tiplinks durchgeführt wurden. Darüberhinaus sind die Ergebnisse durch den Vergleich mit experimentell beobachteten Relativbewegungen validiert, die das Haarbündel infolge von sinusförmiger Anregung bei Distorsionsfrequenzen zeigt. Diese haben ihren Ursprung in dem nichtlinearen Prozess des öffnens von Ionenkanälen. Das entwickelte Modell eines Haarbündels liefert neue Einblicke in den Schlüsselprozess der auditiven Wahrnehmung. Zur Behandlung von Problemen der Fluid-Struktur-Wechselwirkungen bei kleinen Amplituden hat sich der hier ausgearbeitete Ansatz als effizient und zuverlässig erwiesen
Belzner, Katharine Ann. "DPOAE two-source separation in adult Japanese quail (Coturnix coturnix japonica) /." Full-text of dissertation on the Internet (891.53 KB), 2010. http://www.lib.jmu.edu/general/etd/2010/doctorate/belzneka/belzneka_doctorate_04-19-2010_02.pdf.
Full textLe, Maître Anne. "Locomotion et morphologie du labyrinthe osseux chez les hominoïdes actuels. Application à Sahelanthropus tchadensis (Hominidae, 7 Ma, Tchad)." Thesis, Poitiers, 2015. http://www.theses.fr/2015POIT2311/document.
Full textHumans are characterised by a specific form of bipedal locomotion. Toumaï, holotype specimen of Sahelanthropus tchadensis discovered in Chad, is the oldest known member of the human branch. Dated from 7 million years ago, it is very close to the dichotomy between this branch and the branch of chimpanzees. Therefore, it gives valuable information on the first stages of the evolution of locomotion is this group. The purpose of this work is to reconstruct the locomotor behaviour of Sahelanthropus tchadensis based on the study of the osseous part of its labyrinth, the balance organ.To this aim, the relationships between the locomotion and the bony labyrinth morphology are investigated in extent hominoids. The covariations between the labyrinth and the skull are studied in Homo sapiens in order to determine the influence of cranial integration on labyrinth morphology. Finally, these results are applied to the bony labyrinth of Toumaï, compared to other hominin fossils.Geometric morphometrics discriminates all extant species by the relative orientation, size and shape of each part of the labyrinth. However, the torsion and the relative orientation of the semicircular canals are mainly due to the integration of the labyrinth in the skull (petrous pyramids and face orientations relative to the midline of the basicranium). On the contrary, canal eccentricity and size are linked only to locomotion.In Sahelanthropus tchadensis, the canal size indicates that this species was more agile than great apes. However, it does not have the semicircular canal rotations characterising the genus Homo. The shape of its canals constitutes a unique combination of features: a round posterior canal and a slightly stretched anterior canal, as in humans and australopithecines, but a slightly posterolaterally projected lateral canal, as in gorillas and baboons. This is the sign of a locomotor behaviour associating vertical climbing in trees to both bipedalism and quadrupedalism on the ground
Vázquez, Echeverría Citlali. "Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7157.
Full textMourlam, Mickaël. "Région auditive des Artiodactyles : signal phylogénétique et écologique." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTG072.
Full textThe discovery by both molecular biology and palaeontological data that cetaceans are artiodactyls constitutes one of the major breakthroughs in mammal’s evolutionary history of the past 30 years. However, no consensus has yet been reached regarding the basal relationship within the enlarged Artiodactyla clade and major questions of its evolutionary history remain to be solved. This thesis explores a promising source of phylogenetic characters: the auditory region (petrosal bone, tympanic bulla, middle ear ossicles, inner ear) from the new perspectives offered by µCT Scan imaging.The main objectives of this thesis are (1) to determine the phylogenetic signal carried by the auditory region in artiodactyls in order to provide a new source of characters to the analyses and (2) to explore the ecological signal carried by the different elements of this sensory region dedicated to hearing (outer ear, middle ear and cochlear canal of the bonny labyrinth) and to equilibrioception (vestibule and semicircular canals of the bony labyrinth).The first part of this thesis (I) brings us to Togo, where many fossil remains of the auditory region of ancient “legged whales” (Protocetida Stromer 1908) have been collected. From an anatomical viewpoint, these fossil remains document a nearly complete petrotympanic complex and allowed us to describe for the first time, the stapes, incus and bony labyrinth of a protocetid whale, which are crucial elements to understand their hearing. Morphofunctional analysis indicates that optimal hearing was probably possible both in air and underwater for these semi-aquatic whales. In addition, the morphology of their cochlea indicates that their hearing ability was close to that of their terrestrial kin and that the specializations related to the remarkable hearing abilities of modern cetaceans (i.e. sensitivity to infra- or ultrasound) occurred after the historical separation between mysticetes and odontocetes.The second part of this work (II) focuses on the origins of amphibiosis in Cetancodonta, through the study of several fossil families, known for their potamophilous tendencies. The study of the auditory region of hippopotamoids (Anthracotheriidae + Hippopotamidae) reveals that adaptation to a semi-aquatic lifestyle has emerged several times (i.e. in a convergent way) in its evolutionary history and seems to indicate a terrestrial origin for this group. As for the raoellid Indohyus, its petro-tympanic complex presents a combination of features suggesting some degree of adaptation to the aquatic environment, but the functional study of its cochlea indicates that this taxon probably could not hear efficiently underwater.The last point of this thesis explores the phylogenetic potential of the auditory region through an analysis built upon morphological characters of the petrosal and bony labyrinth at Artiodactyla scale. For the first time, the results of our analysis are consistent with that of molecular analyses. Among the most notable points, the Cetancodonta clade is well supported by the morphology of the petrosal and Indohyus’ position strongly suggests that raoellids are cetaceans.Thus, the auditory region turns out to be an essential element from a phylogenetic and morphofunctional viewpoint. Indeed, as we have seen throughout this thesis, when the complex and multifaceted nature of the auditory region is apprehended as a whole, it allows to infer the ecology of a given taxon and to clarify its phylogenetic relationships. Thus, the auditory region is still far from having said its last words… and we are not done hearing about it yet
Jones, Gareth Paul. "Acoustic sensitivity of the vestibular system and mechanical analysis of the tectorial membrane in mammals." Thesis, University of Sussex, 2012. http://sro.sussex.ac.uk/id/eprint/38740/.
Full textKorchagina, Julia Jurievna. "In vitro and in vivo analysis of the assembly of the non-collagenous tectorial membrane matrix." Thesis, University of Sussex, 2013. http://sro.sussex.ac.uk/id/eprint/47236/.
Full textDanilo, Laure. "Evolution des structures neurocrâniennes des Equoidea (Mammalia, Perissodactyla) européens paléogènes." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20190/document.
Full textThe Equoidea adaptive radiation still remains badly known, especially due to the ignorance of their phylogeny. The main indecision of these relationships concerns the pachynolophs, European Equoidea either approached to the Equidae or to the Palaeotheriidae. During a great part of the Eocene times, Europe was isolated, and, at the end of this period, has undergone strong climatic changes. That isolation ended at the « Grande Coupure » event, whereas an arid climate moved, and migrant faunas caused the extinction of many endemic groups. A basal European Equoidea, richly represented by well-preserved material, can support one of the latest phylogenetic hypotheses. However, commonly used characters to discuss this issue do not provide a clear and definitive answer.Therefore, this study aims to investigate on unexplored regions of these animals as the neurocranium through microtomography (CT), which allows access to non-destructive structures (brain, petrosal, bony labyrinth, and sinus).Furthermore phylogenetic interest these bodies may, through their functions, harbor paleoecological interest. Until now, few large-scale studies have focused on those structures in the Perissodactyla, with regard to most were anecdotal reports. As a prerequisite, a model study was performed on a wild current Equidae to better understand the variability of these unknown structures. For the first time, a large sample of European Equoidea has been scanned and their neurocranium structures virtually reconstructed in three-dimensions. A total of 20 species were sampled, covering the evolution of these animals from their origin to their extinction, for over 20 million years. Their skulls were scanned; their internal structures reconstructed compared and analyzed using cladistics. A new phylogenetic hypothesis provides intra Equoidea relationships and shows the relevance of neurocranium characters, while driving to consider a larger study. The Palaeotheriidae appears as a highly diverse group, particularly with regard to Eocene Equidae in North America, and characterized by a mosaic evolution. Their brain evolved earlier than that of contemporary faunas (Equidae, Cetartiodactyla, Carnivora); which may partially explain the strong diversification of that family, through the development of new adaptive strategies
Koehler, Karl R. "Reconstitution of mouse inner ear sensory development from pluripotent stem cells." Thesis, 2014. http://hdl.handle.net/1805/6238.
Full textThe inner ear contains specialized sensory epithelia that detect head movements, gravity and sound. Hearing loss and imbalance are primarily caused by degeneration of the mechanosensitive hair cells in sensory epithelia or the sensory neurons that connect the inner ear to the brain. The controlled derivation of inner ear sensory epithelia and neurons from pluripotent stem cells will be essential for generating in vitro models of inner ear disorders or developing cell-based therapies. Despite some recent success in deriving hair cells from mouse embryonic stem (ES) cells, it is currently unclear how to derive inner ear sensory cells in a fully defined and reproducible manner. Progress has likely been hindered by what is known about induction of the nonneural and preplacodal ectoderm, two critical precursors during inner ear development. The studies presented here report the step-wise differentiation of inner ear sensory epithelia from mouse ES cells in three-dimensional culture. We show that nonneural, preplacodal and pre-otic epithelia can be generated from ES cell aggregates by precise temporal control of BMP, TGFβ and FGF signaling, mimicking in vivo development. Later, in a self-guided process, vesicles containing supporting cells emerge from the presumptive otic epithelium and give rise to hair cells with stereocilia bundles and kinocilium. Remarkably, the vesicles developed into large cysts with sensory epithelia reminiscent of vestibular sense organs (i.e. the utricle, saccule and crista), which sense head movements and gravity in the animal. We have designated these stem cell-derived structures inner ear organoids. In addition, we discovered that sensory-like neurons develop alongside the organoids and form putative synapses with hair cells in a similar fashion to the hair cell-to-neuron circuit that forms in the developing embryo. Our data thus establish a novel in vitro model of inner ear organogenesis that can be used to gain deeper insight into inner ear development and disorder.
Ekdale, Eric Gregory. "Variation within the bony labyrinth of mammals." 2009. http://hdl.handle.net/2152/7862.
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Compton, Vanessa. "Understanding the labyrinth as transformative site, symbol, and technology : an arts-informed inquiry /." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=510526&T=F.
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