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Journal articles on the topic 'Laboratory Risks'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Piccaluga, E., M. G. Andreassi, M. R. Chiesa, L. Fortunato, G. Trivellini, S. Molinaro, G. Cremonesi, G. Guagliumi, and E. Picano. "Occupational risks in cardiac catheterization laboratory workers." European Heart Journal 34, suppl 1 (August 2, 2013): P5478. http://dx.doi.org/10.1093/eurheartj/eht310.p5478.

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2

Fulginiti, Vincent A. "The Risks of Vaccinia in Laboratory Workers." Journal of Investigative Dermatology 120, no. 3 (March 2003): viii. http://dx.doi.org/10.1046/j.1523-1747.2003.12072.x.

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3

Choël, Léon, Brigitte Grosgogeat, Denis Bourgeois, and Jacques Descotes. "Occupational toxic risks in dental laboratory technicians." Journal of Environmental Medicine 1, no. 4 (October 1999): 307–14. http://dx.doi.org/10.1002/jem.44.

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4

Dougall, Annette M., Tim R. Brinkley, and Brian D. Clarke. "Imported biologicals: unforeseen biosecurity risks in the laboratory." Microbiology Australia 41, no. 3 (2020): 132. http://dx.doi.org/10.1071/ma20035.

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Imported biological products are ubiquitous necessities of modern life that can pose significant biosecurity risks to Australia. Products produced using animal material are used everywhere from enzymes in cleaning products, to cell lines and bacterial cultures used to produce vaccines and medicines. This article highlights adventitious agents of biologicals and provides an overview of the considerations and regulatory tools administered under the Biosecurity Act 2015 (Commonwealth) to manage these biosecurity risks whilst still facilitating imports of biologicals.

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5

MacNeil, Adam, Mary G. Reynolds, and Inger K. Damon. "Risks associated with vaccinia virus in the laboratory." Virology 385, no. 1 (March 2009): 1–4. http://dx.doi.org/10.1016/j.virol.2008.11.045.

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6

Geha, Albert. "Controlling your risks: HIV in the research laboratory." Biochemical Education 23, no. 1 (January 1995): 43. http://dx.doi.org/10.1016/0307-4412(95)90195-7.

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7

Steelman, C. "Unique Occupational Health Risks in Cardiac Catheterization Laboratory Workers." Journal of Medical Imaging and Radiation Sciences 53, no. 4 (December 2022): S8. http://dx.doi.org/10.1016/j.jmir.2022.10.028.

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8

Steelman, C. "Unique Occupational Health Risks in Cardiac Catheterization Laboratory Workers." Journal of Medical Imaging and Radiation Sciences 53, no. 4 (December 2022): S7. http://dx.doi.org/10.1016/j.jmir.2022.10.025.

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9

Raabe, O. G. "Scaling of Fatal Cancer Risks from Laboratory Animals to Man." Health Physics 57 (July 1989): 419–32. http://dx.doi.org/10.1097/00004032-198907001-00059.

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10

Evans, Mark, and Howard Cuckle. "729: Performance adjusted risks (par) for optimization of laboratory analytes." American Journal of Obstetrics and Gynecology 204, no. 1 (January 2011): S287. http://dx.doi.org/10.1016/j.ajog.2010.10.751.

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11

Lamanna, R., A. Pinna, T. Bettini, E. Rimini, M. Pradella, L. F. Simula, M. R. Fanello, M. Moffa, and L. Rossi. "Biological risks related to unintentional movements or behavior laboratory attendant." Clinica Chimica Acta 493 (June 2019): S312—S313. http://dx.doi.org/10.1016/j.cca.2019.03.644.

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12

Shoptaugh, Carol F. "Risktaking and Driver Behaviors: A Laboratory Study." Proceedings of the Human Factors Society Annual Meeting 32, no. 15 (October 1988): 923–27. http://dx.doi.org/10.1518/107118188786761839.

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A number of variables have been implicated as predictors of actual risky driving behaviors. However, due to differing methodologies, the literature shows few consistent findings. The current study is an attempt to establish a more complete understanding of the relationship between risk related characteristics and actual risktaking decisions. It was predicted that individuals who had a greater propensity for taking risks would also be more prone to making risky decisions in a simulated driving task. Sixty subjects (30 male, 30 female) were selected based on their Kogan and Wallach Choice Dilemma risktaking scores (15 high and 15 low risktakers in each gender group). Subjects participated in two 1 1/2 hour experimental sessions. Session one was a video tape risk choice session and session two, a battery of demographic, driving and risktaking characteristic questionnaires were given. The most significant finding in this study involved the misuse of speed and distance in making turn decisions. All subjects adopted a safer criterion than the normative model for left turn gap distances, but for right turn merging gaps high risktaking subjects perceived significantly more gaps as safe than did low risktaking subjects. Further, as speed increased from 30mph to 55mph all subjects believed more gaps to be safe for right turn merging. This miscalculation could result in a rear end accident. Most demographic, driver and risktaking measures failed to correlated significantly with risky decision making. Only the Choice Dilemma and the Pelz-Schuman Impulsivity questionnaire correlated with each other and the risky driver decisions.

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13

Mariana, Deacu, Așchie Mariana, Bălțătescu Gabriela Izabela, and Boșoteanu Mădălina. "Assessment of Quality and Risks Exposure in Histopathology Department." ARS Medica Tomitana 24, no. 1 (February 1, 2018): 33–39. http://dx.doi.org/10.2478/arsm-2018-0007.

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Abstract The role of histopathology department in establishing a correct and final diagnosis is essential, this leading to an effective treatment for the patient so its healing to be complete. In order to achieve this goal, it is necessary that all complex steps belonging to this department to be properly carried out because any mistakes in a pathology report may adversely affect the patient outcome. Therefore, it is mandatory the quality assessment of all procedures from the laboratory to be constantly done so that the report to be reliable and accuracy. All three main categories of activities specific to a pathological laboratory (pre-analytic, analytic and post-analytic phases) must undergo quality control. During the progress of these phases, it also must be identified the risks and safety problems regarding the personal staff. These may be different for each activity or procedure which is performed by the laboratory workers. All the physical, chemical or biological hazards must be identified to assess, appreciate the possible risks and to implement preventive measures. The aim of this study is to highlight the importance of quality management for all phases included in a surgical pathological laboratory based on the pathological errors observed, identify emerging risks exposure and necessary measures to prevent them.

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14

Defoe, Ivy N., Judith Semon Dubas, and Daniel Romer. "Heightened Adolescent Risk-Taking? Insights From Lab Studies on Age Differences in Decision-Making." Policy Insights from the Behavioral and Brain Sciences 6, no. 1 (March 2019): 56–63. http://dx.doi.org/10.1177/2372732218801037.

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Surveys concur that adolescents disproportionately engage in many real-world risk behaviors, compared with children and adults. Recently researchers have employed laboratory risky decision-making tasks to replicate this apparent heightened adolescent risk-taking. This review builds on the main findings of the first meta-analysis of such age differences in risky decision-making in the laboratory. Overall, although adolescents engage in more risky decision-making than adults, adolescents engage in risky decision-making equal to children. However, adolescents take fewer risks than children on tasks that allow the option of opting out of taking a risk. To reconcile findings on age differences in risk-taking in the real-world versus the laboratory, an integrative framework merges theories on neuropsychological development with ecological models that emphasize the importance of risk exposure in explaining age differences in risk-taking. Policy insights and recent developments are discussed.

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15

Barnett, Michael, Yael Barnett, and Stephen Reddel. "MRI and laboratory monitoring of disease-modifying therapy efficacy and risks." Current Opinion in Neurology 35, no. 3 (June 2022): 278–85. http://dx.doi.org/10.1097/wco.0000000000001067.

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16

Wood, Mark D., and Kenneth J. Sher. "Risks of alcohol consumption in laboratory studies involving human research participants." Psychology of Addictive Behaviors 14, no. 4 (2000): 328–34. http://dx.doi.org/10.1037/0893-164x.14.4.328.

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17

Sorochkina, O. Y., L. A. Romanova, and A. S. Fedchenko. "Assessment of risks and opportunities of metrological support of the laboratory." Journal of Physics: Conference Series 1679 (November 2020): 052049. http://dx.doi.org/10.1088/1742-6596/1679/5/052049.

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18

Ismail, Ahmed A., and Firas H. Abdulrazzak. "Laboratory Instruments Classification and Risks Use with Safety for Less Mistakes." Journal of Physics: Conference Series 1294 (September 2019): 052077. http://dx.doi.org/10.1088/1742-6596/1294/5/052077.

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19

Baron, Ellen Jo, and J. Michael Miller. "Bacterial and fungal infections among diagnostic laboratory workers: evaluating the risks." Diagnostic Microbiology and Infectious Disease 60, no. 3 (March 2008): 241–46. http://dx.doi.org/10.1016/j.diagmicrobio.2007.09.016.

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20

Dement, John M., and John R. Cromer. "Cancer and Reproductive Risks Among Chemists and Laboratory Workers: A Review." Applied Occupational and Environmental Hygiene 7, no. 2 (February 1992): 120–26. http://dx.doi.org/10.1080/1047322x.1992.10388032.

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21

Koltsova, E. M., E. N. Balashova, M. A. Panteleev, and A. N. Balandina. "Laboratory aspects of hemostasis in neonates." Pediatric Hematology/Oncology and Immunopathology 17, no. 4 (January 13, 2019): 100–113. http://dx.doi.org/10.24287/1726-1708-2018-17-4-100-113.

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Newborns have high risks of thrombotic and hemorrhagic complications. Despite the fact that the overall frequency of thrombosis and bleeding in the general population of neonates is low, the risks of both thrombosis and hemorrhage are significantly increased when a newborn has some complications, including prematurity. The mechanisms underlying the onset of thrombotic and hemorrhagic complications in newborns are not fully understood and remain controversial. The hemostasis in newborns drastically differs from adult hemostasis and even from hemostasis in children older than a year. Nevertheless, despite the presence of quantitative and qualitative differences of almost all parameters of the hemostasis system from the parameters of adults, healthy newborns as a whole have clinically normal functional hemostasis without a tendency to coagulopathy or thrombosis. Apparently, the neonatal hemostasis system is in some alternative "balance", which differs from the "balance" of hemostasis in adults. The issue regarding the stability of this balance is still open. Due to the peculiarities of the newborn's hemostasis, clinical laboratory diagnostics of the coagulation disorders is very difficult, and the attending physician is forced to focus exclusively on the clinical picture. This review provides basic information on the neonatal hemostasis system, as well as an attempt to critically evaluate existing laboratory tests in terms of applicability for this group of patients.

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22

Parvanescu, Cristina Dorina, Andreea Lili Barbulescu, Paulina Lucia Ciurea, Beatrice Andreea Chisalau, Sineta Cristina Firulescu, Adina Turcu Stiolica, Stefan Cristian Dinescu, et al. "Gout - Risks, Comorbidities and Associations." Revista de Chimie 70, no. 8 (September 15, 2019): 2948–53. http://dx.doi.org/10.37358/rc.19.8.7462.

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Being the most common inflammatory arthritis, gout is highly associated to several comorbidities that have important consequences on patient�s prognosis and are related to a frequent premature mortality. The study aimed to analyse the type and frequency of gouty arthritis related comorbidities, by testing for correlations between plasma level of uric acid and a series of clinical features and laboratory markers associated with inflammatory status, metabolic abdormalities and systemic complications. After analysing the results, we noticed the presence of comorbidities in signficant percentages, directly correlated to serum uric acid levels. Our observations underline the necesity of a complex evaluation, in order to reveal even subclinical associated pathologies and prevent possible events, with an input on patients� prognosis.

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23

Gunawan, Agie Adhitya, and Christine Suryadi. "Pengembangan Model Pengelolaan Risiko Sistem Informasi Berbasis FMEA dan ISO 31000:2009 Sebagai Pendukung K3L di Laboratorium." Jurnal Reka Lingkungan 10, no. 1 (June 4, 2021): 79–90. http://dx.doi.org/10.26760/rekalingkungan.v10i1.79-89.

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AbstrakLaboratory Information Management Systems (LIMS) merupakan SI berbasis komputer yang bermanfaat bagi laboratorium dalam meningkatkan keamanan, produktifitas dan akurasi data, mengelola semua informasi yang berkaitan dengan kegiatan laboratorium serta memungkinkan laboratorium untuk menampilkan data serta laporan secara cepat. Penelitian dilakukan dengan cara merancang model pengelolaan risiko SI untuk menilai risiko-risiko yang berkaitan dengan pemanfaatan SI di Laboratorium Uji Kimia X dengan memanfaatkan kerangka kerja FMEA dan acuan ISO 31000. Penerapan model pada Laboratorium Uji Kimia X berhasil mengidentifikasi enam belas risiko SI. Sementara hasil penilaian dan analisis risiko-risiko SI tersebut menyatakan bahwa terdapat dua risiko yang termasuk kedalam kategori kritis dengan nilai Risk Priority Number (RPN) secara berurutan yaitu 75 dan 100. Sistem ini dapat diterapkan untuk mendeteksi bahaya dan risiko di laboratorium lingkungan.Kata kunci: FMEA, ISO 31000, LIMS, risiko SI, environmental laboratory.AbstractLaboratory Information Management Systems (LIMS) is a computerized IS used by laboratory to increase safety, data productivity and accuracy, manage information related to laboratory activities and allow laboratory to display data and reports faster. The research was conducted by creating IS risk management model using FMEA framework and ISO 31000 standard to assess risks related to IS implementation in Chemical Testing Laboratory X. The result of model testing in case study Chemical Testing Laboratory X manage to identify 16 IS risks threatening IS assets. Analysis of these risk produce two risks that fall in critical category. UTP cable damage and data input errors. Risk Priority Number (RPN) value for each risks are 100, and 75, respectively. This system can be implemented to detect the risk of hazards that may occur in the environmental laboratory.Keywords: FMEA, ISO 31000, LIMS, IS risks, IS assets, environmental laboratory.

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24

Chiripuci, Nicușor, Emil Avram, and Laurențiu Mocanu. "Diving Protection Against Nuclear Contaminants." Land Forces Academy Review 25, no. 1 (March 1, 2020): 61–67. http://dx.doi.org/10.2478/raft-2020-0008.

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AbstractThe risks of radioactive water contamination are high today and divers can make a decisive contribution to removing these risks. The equipment used and the diving procedures are specific. The specialists of the Research Laboratory, in collaboration with those of the Hyperbaric Laboratory of the Diving Center from Constanta, have contributed to the development of this equipment and the diving procedures in the radioactive contaminated environment.

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25

Kochetov, A. G., O. V. Lyang, I. A. Zhirova, and O. O. Ivoilov. "Laboratory diagnostics in medicine." Terapevticheskii arkhiv 92, no. 4 (May 19, 2020): 4–8. http://dx.doi.org/10.26442/00403660.2020.04.000501.

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The development of clinical laboratory diagnostics is in line with the evidence-based medicine, which requires that clinical decisions have to be based on diagnostic methods with proven informativity. This creates a request for the scientific validity of the use of laboratory researches and application of probabilistic interpretation tools corresponding to the tasks. The concept of indefiniteness (analytical, biological and clinical) is at the heart of interpretation of laboratory results. The inclusion of laboratory research in clinical guidelines, the choice and appointment of this research to the patient should not be made from the position of ideas about increasing or decreasing the laboratory index in the disease, but on the basis of its scientifically proven characteristics as a laboratory biomarker sensitivity, specificity, predictive value, as well as the relationship with certain clinical events, outcomes, risks. These characteristics are probabilistic and can be defined.

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26

ZUBAREVA, I. M., N. B. MITINA, and N. V. MALYNOVSKA. "GENERAL RULES FOR SAFE WORK WITH BIOLOGICAL AGENTS." Ukrainian Journal of Civil Engineering and Architecture, no. 5 (December 8, 2022): 43–50. http://dx.doi.org/10.30838/j.bpsacea.2312.251022.43.890.

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Problem statement. The work was carried out on the identification and distribution by groups of various types of emergency situations that are possible in laboratories when performing procedures with various biological agents. The need to observe clearly regulated rules for safe work with various biological objects in laboratory institutions is proved. The purpose of the article. Determine the rules for safe work with various biological agents in laboratory conditions of different security levels. Method. Analytical methods, generalizing approaches to information presented in regulatory documents, literary and other information sources. Results. Existing and previously developed rules for safe work and techniques for appropriate laboratory work with biological objects are studied. The main signs of work risks according to the international classification of microorganisms are investigated. The characteristics of each hazard group are studied and examples of microbial species assigned to a particular risk group are given. The classification characteristics for four types of microbiological laboratories according to a number of features are given. It was established that the level of laboratories’ biological safety depends on the risk group of microorganisms. It is recognized that compliance with the rules of safe work with various biological agents in laboratory conditions is ensured by the use of necessary and mandatory equipment for a certain level of the laboratory. It is argued that the possibility of implementing biological safety rules in laboratories of different levels is based on the assessment of biological risks in certain conditions of a given laboratory institution. A step-by-step procedure for assessing biological risks in a certain laboratory has been developed, which is also presented in the form of a block diagram. Scientific novelty. Scientific and normative information on the rules of safe work with biological agents in laboratory conditions is analyzed and summarized. A defined sequence of actions for biological risk assessment in certain laboratory settings is proposed. Practical value. The practical possibility and necessity of managing biological risks in laboratory conditions of different biological safety levels is substantiated.

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27

Clayton, April M., James Hayes, George W. Lathrop, and Nathaniel Powell. "Development of an Occupational Risk Assessment Tool for Laboratory Animal Facilities." Applied Biosafety 24, no. 2 (March 24, 2019): 72–82. http://dx.doi.org/10.1177/1535676019831915.

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Introduction: Laboratory animal facilities aim to provide excellence in animal care and welfare and support scientific research. Critical to these goals is to ensure a safe work environment for personnel comprising veterinary and animal care, laboratory research, and maintenance staff. Objective: Thus, performing occupational risk assessments allows for evaluation of risks from identified hazards associated with a variety of tasks ongoing in laboratory animal facilities. Methods: Herein, we present the development of an occupational risk assessment tool purposed to capture the dynamics of work performed in laboratory animal facilities, calculate and prioritize identified risks associated with procedures and processes, and inform and evaluate risk mitigations. Results: We also discuss a risk assessment for refining sharps use in nonhuman primate husbandry and care to demonstrate the utility of this tool to improve occupational safety in our animal facility. Conclusion: This tool and framework evolve into a holistic occupational risk management system that identifies, evaluates, and mitigates occupational risks; determines risk acceptability; consistently ensures communication and consultation with frontline personnel, stakeholders, senior leadership, and subject matter experts in biosafety, science, and animal care and welfare; and continuously strives to improve and enhance the operations of laboratory animal facilities.

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28

Arvidsson, Rickard, and Steffen Foss Hansen. "Environmental and health risks of nanorobots: an early review." Environmental Science: Nano 7, no. 10 (2020): 2875–86. http://dx.doi.org/10.1039/d0en00570c.

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Nanorobots for biomedical applications have experienced extensive research and rapid development during the last decade, up to a point where they can now deliver cargos to designated sites in organisms under laboratory conditions.

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29

Keating, Fergal. "Managing Safety in a Failure Analysis Laboratory." EDFA Technical Articles 11, no. 3 (August 1, 2009): 20–27. http://dx.doi.org/10.31399/asm.edfa.2009-3.p020.

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Abstract This article discusses the importance of failure analysis lab safety and presents best practices for setting up and maintaining an effective safety program. It explains how to identify hazards and assess risks associated with X-ray and laser radiation, liquid nitrogen, compressed gases, and soldering processes. It also discusses the use of personal protective equipment, the implementation of practical controls, key performance indicators, and safety standards and regulations.

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30

Galas, Radovan, Milan Omasta, and Martin Hartl. "Top-of-Rail Lubricants: Potential Risks and Benefits." Proceedings 2, no. 16 (September 17, 2018): 1140. http://dx.doi.org/10.3390/proceedings2161140.

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Top-of-rail (TOR) lubricants represent modern approach for friction modification between wheel and rail. The main goal of this study was to investigate potential risks and benefits associated with the application of these products, especially in terms of adhesion, wear, and noise. For this purpose, both laboratory and field experiments were carried out.

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31

Sobrinho-Junior, Sidney Afonso, Azriel Cancian Nepomuceno de Almeida, Amanda Aparecida Paniago Ceabras, Carolina Leonel da Silva Carvalho, Tayla Borges Lino, and Gustavo Christofoletti. "Risks of Accidents Caused by the Use of Smartphone by Pedestrians Are Task- and Environment-Dependent." International Journal of Environmental Research and Public Health 19, no. 16 (August 19, 2022): 10320. http://dx.doi.org/10.3390/ijerph191610320.

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Using smartphones during a task that requires an upright posture can be detrimental for the overall motor performance. The aim of this study was to determine the risks of accidents caused by the use of smartphones by pedestrians while walking in a controlled (laboratory) and a non-controlled (public street) environment. Two hundred and one participants, 100 men and 101 women, all young adults, were submitted to walking activities while texting messages and talking on the phone. The risk of accident was measured by the time and the number of steps necessary to walk a 20 ft distance. Assessments were performed with no external distractors (laboratory) and on a public street with vehicles, pedestrians, lights, and noises. Multivariate analysis of variance tests provided the main effect of task (using × not using smartphone), environment (laboratory × street), sex (men × women), and interactions. Significance was set at 5%. The results showed that using a smartphone while walking demanded a greater number of steps and time to perform the task (main effect of task: 0.84; p = 0.001). The risk of accident was higher on the streets where, due to traffic hazards, pedestrians performed the task faster and with a lower number of steps (the main effect of environment: 0.82; p = 0.001). There was no difference of risks between men and women (main effect of sex: 0.01; p = 0.225), whether in the laboratory or on the street (main effect of sex × environment: 0.01; p = 0.905). The task × environment interaction showed that using a smartphone on the street potentiates risks of accidents of pedestrians (main effect of task × environment: 0.41; p = 0.001). In conclusion, using a smartphone while walking can be risky for pedestrians, especially in a traffic environment. People should avoid using their smartphone while crossing streets.

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32

Bondareva, E. D., K. E. Borovkova, and M. N. Makarova. "Risk-Based Approach to the Assessment of Sanitary Safety of Vivariums and Breeding Facilities, and Health Status of Personnel and Laboratory Animals." Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 10, no. 4 (December 11, 2020): 257–66. http://dx.doi.org/10.30895/1991-2919-2020-10-4-257-266.

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The paper discusses the system of managing risks arising during preclinical studies (risks for the health of personnel and laboratory animals, as well as risks associated with sanitation of premises) as a way to improve and control the efficiency of processes and the safety of facilities involved in preclinical studies.The aim of the study was to analyse the risk assessment system’s efficiency for improvement of drug safety assessment during preclinical studies in the context of animal care and use programmes.Materials and methods: the Failure Mode Effect Analysis (FMEA) method was used to assess the sanitary and hygienic conditions in laboratory animal facilities, as well as health status and welfare of laboratory animals and the attending personnel. The study checked the presence of pathogenic and opportunistic microflora as the main potential inconsistencies.Results: the risk assessment performed during monitoring of laboratory animal health, monitoring of surface cleanliness, and assessment of personnel health, helped to establish a list of the most dangerous pathogens that require stricter control. In order to reduce risks arising during preclinical studies, the following set of measures was proposed: monitoring of the living environment and health of laboratory animals, revision of therapeutic and preventive measures for laboratory animals (including adjustment of antibiotic treatment depending on antimicrobial resistance of microorganisms), monitoring of the personnel health status, taking measures to enhance the personnel vigilance with respect to their own health, prohibition to work at the premises for employees showing symptoms, control of how the employees showing symptoms observe the prohibition to work at the premises, organisation of periodic medical examinations for personnel having contact with laboratory animals.Conclusions: the risk-based assessment helped to identify the most dangerous potential inconsistencies (pathogenic and opportunistic microflora) and the necessary preventive measures to control and manage potential risk consequences.

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Opitz, A. K. B., Jennifer L. Broadhurst, and Susan T. L. Harrison. "Assessing Environmental Risks Associated with Ultrafine Coal Wastes Using Laboratory-Scale Tests." Advanced Materials Research 1130 (November 2015): 635–39. http://dx.doi.org/10.4028/www.scientific.net/amr.1130.635.

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Characterisation of the risk of acid rock drainage is typically achieved through the quantification of acid-generating and acid-consuming components present within a sample using initial laboratory-scale, chemical static tests. Such tests, however, consider ARD generation under chemical conditions and do not account for the role of micro-organisms. Their focus is exclusively on the net potential for acid generation, with no account of metal deportment or the relative rate of acid generation and consumption. The present study investigates the ARD potential of two ultrafine coal wastes samples using the standard static tests as well as the UCT biokinetic test to account for microbial ARD generation. The deportment of metal species under each test condition was also considered. The UCT biokinetic test results supported the static test classification, adding provided preliminary kinetic data on the ARD generation. Sequential chemical extraction tests allowed for differentiation of the host minerals according to their leaching potentials, providing supporting evidence for the deportment of metal species under the characterisation tests, thereby improving the knowledge base on which to classify coal wastes as benign or otherwise.

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34

Byun, Hyae-Jeong, and Jeong-Im Park. "A Review on Chemical Exposure and Related Health Risks in Laboratory Workers." Korean Journal of Environmental Health Sciences 36, no. 6 (December 30, 2010): 441–55. http://dx.doi.org/10.5668/jehs.2010.36.6.441.

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35

Haines, David E. "A paradigm shift to address occupational health risks in the EP laboratory." Heart Rhythm 17, no. 5 (May 2020): 681–82. http://dx.doi.org/10.1016/j.hrthm.2019.12.018.

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36

Kustono, Djoko, Poppy Puspitasari, Muhammad Al Irsyad, Aisya Nursabrina, and Erry Yulian Triblas Adesta. "Identification of Occupational Accident Risks in Nanomaterial Laboratories in Higher Education Based on Human Factors." International Journal of Mechanical Engineering Technologies and Applications 2, no. 1 (February 26, 2021): 79. http://dx.doi.org/10.21776/mechta.2021.002.01.12.

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The article describes a concept of health and safety to conduct research in Nanomaterial Laboratory in Two Public University in Malang, East Java, Indonesia. The utilization of nanomaterials in the world of education has been done in two universities in Malang, namely Malang State University and Brawijaya University. The nanomaterial laboratory as a means for research and development of nanomaterial science that often creates hazards and risks of work accidents for its users, but things that are often not realized. Dangers and risks of work accidents caused by the absence of standards. This research focuses on hazards and accidents in the nanomaterial laboratory using the HIRA (Hazard Identification and Risk Assessment) method, which is then followed by a variety of independent variables. The population in this study were nanomaterial researchers at two universities in Malang. Based on the results of trials between respondents 'competency expertise with the level of risk of workplace accidents in the nanomaterial laboratory obtained p- value 0.00 (<0.05), meaning that there is a significant relationship between the respondents' scientific conservation and the level of work accident risk in the nanomaterials laboratory. Furthermore, the results of the study were also obtained between the research respondents with the level of risk of work accidents in the nanomaterial laboratory with a p-value of 0.00 (<0.05), meaning that there was a significant correlation between the respondent's research experience and the level of work accident risk in the nanomaterial laboratory.

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37

Ellis, Gary B. "Office for Protection from Research Risks (OPRR)." Politics and the Life Sciences 13, no. 2 (August 1994): 271–73. http://dx.doi.org/10.1017/s0730938400018591.

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The Office for Protection from Research Risks (OPRR) has primary responsibility within the U.S. Department of Health and Human Services (DHHS) for developing and implementing policies, procedures, and regulations for the protection of human subjects involved in research. It also has primary responsibility within the U.S. Public Health Service for developing and implementing policies and procedures for the care and use of laboratory animals. And, it has responsibility for coordinating the development and implementation of policies, procedures, and regulations for the protection of human subjects involved in research for all U.S. federal departments and agencies that conduct or support such research.

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Rabinowitz, Peter M., Matthew L. Scotch, and Lisa A. Conti. "Animals as Sentinels: Using Comparative Medicine To Move Beyond the Laboratory." ILAR Journal 51, no. 3 (January 1, 2010): 262–67. http://dx.doi.org/10.1093/ilar.51.3.262.

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Abstract The comparative medicine approach, as applied to the study of laboratory animals for the betterment of human health, has resulted in important medical and scientific progress. Much of what is known about the human health risks of many toxic and infectious hazards present in the environment derives from experimental studies in animals and observational (epidemiological) studies of exposed human populations. Yet there is a third source of “in vivo” knowledge about host-environment interactions that may be underused and -explored: the study of diseases in naturally occurring animal populations that may signal potential human health threats. Just as canaries warned coal miners of the risk of toxic gases, other nonhuman animals, due to their greater susceptibility, environmental exposure, or shorter life span, may serve as “sentinels” for human environmental health hazards. Traditionally, communication between human and animal health professionals about cross-species sentinel events has been limited, but progress in comparative genomics, animal epidemiology, and bioinformatics can now provide an enhanced forum for such communication. The “One Health” concept involves moving toward a comparative clinical approach that considers “shared risks” between humans and animals and promotes greater cooperation and collaboration between human and animal health professionals to identify and reduce such risks. In doing so, it also creates new opportunities for the field of comparative medicine that can supplement traditional laboratory animal research.

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Dmitrieva, A. A., and E. V. Dmitriev. "Risks of uveitis recurrence in juvenile idiopathic arthritis." Modern technologies in ophtalmology, no. 6 (November 9, 2022): 71–75. http://dx.doi.org/10.25276/2312-4911-2022-6-71-75.

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This paper analyses the medical cases of patients with juvenile idiopathic arthritis with eye damage. The analysis results show that basic methotrexate chemotherapy singly or in combination with genetically engineered biological drugs is the most effective solution for controlling the disease process of uveitis. Reduction of age-specific dosage or withdrawal of drugs with sustained clinical laboratory remissions of uveitis bears the risks of recurrence or occurrence of damage to the membranes of the eye. Keywords: uveitis, rheumatoid arthritis, therapy

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Ismulyati, Ismulyati, Rahman Karnila, and Elda Nazriati. "Analisis Penerapan Keselamatan Kerja Pada Petugas Laboratorium Klinik di Kota Pekanbaru." Dinamika Lingkungan Indonesia 3, no. 1 (January 16, 2016): 33. http://dx.doi.org/10.31258/dli.3.1.p.33-41.

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Abstrak: The workers in clinical laboratories were suspected to always threatened a number of risks and potential accidents due to the interaction between the labor, equipment, materials and labor and environmental situation in it. In addition, the lack of understanding and awareness of companies/agencies and workers to anticipated and managed the potential risks in the laboratory in accordance with established standards. Research has been conducted in nine private clinical laboratories from February to December 2014 with 39 respondents of laboratory workers. This research was a quantitative study which using observational design. Data collection techniques in this research was using interviews, direct observation and questionnaires which distributed to the management of clinical laboratory and clinical laboratory workers. The quality of the clinical laboratory in Pekanbaru city of fair quality were three of eight laboratories. The results of clinical laboratory management signified the majority of fair quality that five of the eight laboratories in Pekanbaru city. The results of behavioral assessment of clinical laboratory workers were not well behaved. Measurement of behavior consists of knowledge attitude and practice of clinical laboratory workers. The measurement results of clinical laboratory workers were moderate categorized, nice attitudes, but the practice was not well categorized.

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Caymaz, Belkız. "Secondary School Students' Knowledge and Views on Laboratory Safety." Journal of Science Learning 4, no. 3 (July 1, 2021): 220–29. http://dx.doi.org/10.17509/jsl.v4i3.30752.

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Laboratory studies are very important for science education but also involve various risks. It is possible to minimize these risks by providing a safe working environment. This study aims to determine the knowledge and views of secondary school students on laboratory safety and to identify their deficiencies in this regard. The survey method was used in the study. The study sample consists of 136 students from 6th, 7th, and 8th-grade students of a public secondary school in Kastamonu Province, Turkey. An open-ended questionnaire was used to determine the students' knowledge and views on the subject, and the data obtained were analyzed by the content analysis method. As a result of the study, it was seen that although secondary school students have some general information about laboratory safety, they have deficiencies in terms of most of the information. It was determined that students do not know most of the behaviors that must/must not be made in the laboratory, and they are not aware of some of the safety symbols in the science textbooks. In addition, most of the students stated that they don't feel competent about laboratory safety and need training on this subject.

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Wu, Fan, Bryan J. Harper, Lauren E. Crandon, and Stacey L. Harper. "Assessment of Cu and CuO nanoparticle ecological responses using laboratory small-scale microcosms." Environmental Science: Nano 7, no. 1 (2020): 105–15. http://dx.doi.org/10.1039/c9en01026b.

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Nurliyani, Arlin. "Assessment IT Risk Management at The Computer and Network Laboratory School." JOURNAL OF INFORMATICS AND TELECOMMUNICATION ENGINEERING 3, no. 1 (July 25, 2019): 115. http://dx.doi.org/10.31289/jite.v3i1.2622.

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<p><span>The Computer and Network Engineering Laboratory School is a means for teaching and learning that has problems with information technology. In this research, IT Risk Management Assessment will be carried out at the Computer and Network Engineering Laboratory of School. This research was conducted to determine what risks of what happened. In this study, the NIST SP 800-30r1 Framework method will be used to obtain risk scores. While for data collection techniques will use qualitative analysis. The stages of risk assessment carried out include Prepare for Assessment, Conduct Assessment, Communicate Result, and Maintain Assessment. From the assessment stage, the level of risk obtained is in a moderate position. This assessment was taken from the results of interviews with five respondents in the organization management of The Computer and Network Engineering Laboratory School. Emerging risks have a serious impact on assets, organization and activities in The Computer and Network Engineering Laboratory School.</span></p>

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Whitaker, Kristen Danielle, Ryan Bernhisel, John Kidd, Elisha Hughes, Eric Thomas Rosenthal, and Michael J. Hall. "A single-institution and commercial laboratory database analysis of BRIP1-associated cancer risks." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 1538. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.1538.

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1538 Background: BRIP1/ FANCJ participates in DNA replication and repair via interactions with BRCA1 and possibly MLH1. Previous studies have reported that pathogenic variants (PV) in BRIP1 are associated with an ~2-fold increase in risk for ovarian cancer (OC) and triple-negative breast cancer (TNBC). Although multigene panel testing for hereditary cancer (CA) has identified BRIP1 PV and uncertain variants (VUS) in patients with diverse CAs including breast (BC), colorectal (CRC) and melanoma (Mel), association with these CA types has not been established. Methods: We examined BRIP1 risks in two independent populations: Fox Chase Cancer Center (FCCC) and Myriad Genetics (MGL). At FCCC, pedigrees of BRIP1 PV ( N= 10) and VUS families ( N= 47) were reviewed. The MGL population included patients referred for testing by multigene panel (9/2013-12/2019) ( N= 586,740). Multivariable logistic regression analysis estimated BRIP1 CA risks as odds ratios (ORs) and 95% confidence intervals (CIs). Models were adjusted for age, sex, ancestry, personal CA history (PHX), and family CA history. Results: In the FCCC cohort, BRIP1 PV carriers ( N= 12) reported PHX of early-onset ( < 50) BC, CRC, and bladder CA. BRIP1 VUS were also identified among several patients with striking PHX and negative panel testing: BC < 40 ( N= 3), bilateral BC ( N= 4), TNBC ( N= 2), CRC < 40 ( N= 3), and a patient with 3 CAs < 40 (CRC, BC, and Mel). All FCCC families with a BRIP1 PV and select VUS families ( N= 6) are seen in the Table. In the MGL population, 0.3% (1,678/586,740) carried a BRIP1 PV. Logistic regression analyses found that female BRIP1 PV carriers have significantly increased risk for OC (OR 2.40, 95% CI 1.93-2.98) and TNBC (OR 1.93, 95% CI 1.52-2.46). Data were insufficient for testing risk of bladder or prostate CA. Findings did not support associations of BRIP1 with CRC, melanoma, endometrial, pancreatic or gastric CA. Conclusions: BRIP1 PV and VUS may be identified in patients with diverse CA histories. These results confirm studies showing that BRIP1 PV are associated with an ~2-fold increased risk of OC and TNBC, but do not support increased risks of CRC, melanoma or endometrial CA in BRIP1 PV carriers. [Table: see text]

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Menkhaus, Dale J., Chris T. Bastian, Owen R. Phillips, and Patrick D. O'Neill. "Supply and Demand Risks in Laboratory Forward and Spot Markets: Implications for Agriculture." Journal of Agricultural and Applied Economics 32, no. 1 (April 2000): 159–73. http://dx.doi.org/10.1017/s1074070800027905.

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AbstractLaboratory experimental methods are used to investigate the impacts of supply and/or demand risks on prices, quantities traded, and earnings within forward and spot market institutions. Random demand and/or supply shifts can be as much as 25 percent of the expected equilibrium outcome. Nevertheless, results suggest that the spot or forward trading institution itself has a greater influence on market outcomes than the presence of risk within the trading institution. Sellers tend to have relatively higher earnings in a spot market than buyers, regardless of the risk. Total surplus, however, generally is greater in a forward market.

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Geaghan, Sharon M. "Fetal health assessment in utero by laboratory technologies: Clinical benefits, risks and controversies." Clinical Biochemistry 44, no. 7 (May 2011): 460–62. http://dx.doi.org/10.1016/j.clinbiochem.2011.03.015.

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Jacoby, Robert O., and J. Russell Lindsey. "Risks of Infection among Laboratory Rats and Mice at Major Biomedical Research Institutions." ILAR Journal 39, no. 4 (January 1, 1998): 266–71. http://dx.doi.org/10.1093/ilar.39.4.266.

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Kim-Spoon, Jungmeen, Rachel Kahn, Kirby Deater-Deckard, Pearl Chiu, Laurence Steinberg, and Brooks King-Casas. "Risky decision making in a laboratory driving task is associated with health risk behaviors during late adolescence but not adulthood." International Journal of Behavioral Development 40, no. 1 (March 24, 2015): 58–63. http://dx.doi.org/10.1177/0165025415577825.

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Adolescence is characterized by increasing incidence of health risk behaviors, including experimentation with drugs and alcohol. To fill the gap in our understanding of the associations between risky decision-making and health risk behaviors, we investigated associations between laboratory-based risky decision-making using the Stoplight task and self-reported health risk behaviors. Given that there has been no examination of potential age differences in the associations between risky decision-making and health risk behaviors, we also examined whether the association of risky decision-making with health risk behaviors is consistent across adolescence and adulthood using two-group structural equation modeling (SEM). The results indicated significant differences across the two age groups: adolescents (17–20 year olds) who took more risks on the Stoplight task reported greater frequency and earlier onset of substance use, whereas stoplight performance was not associated with substance use frequency or onset among adults (31–61 year olds). Our findings suggest that a laboratory-based measure of risky decision-making is significantly related to health risk behaviors among adolescents but not among adults.

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Guo, Jeen, Pengcheng Xiang, and Yuanli Lee. "Analyzing and Controlling Construction Engineering Project Gray Rhino Risks with Innovative MCDM Methods: Interference Fuzzy Analytical Network Process and Decision-Making Trial and Evaluation Laboratory." Applied Sciences 12, no. 11 (June 3, 2022): 5693. http://dx.doi.org/10.3390/app12115693.

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Construction engineering projects are costly and require large amounts of labor, physical, and financial resources. The failure of a construction engineering project typically brings huge losses. Previous studies have focused on the identification of risks, but insufficient attention has been given to strategic resource allocation for risk management after risk identification. Statistics show that most construction engineering project failures are caused by common risks. Common risks are called gray rhino risks. This metaphor illustrates that many risks are obvious but dangerous. This study was motivated by the challenge of efficiently managing gray rhino risks with limited inputs. The literature suggests that gray rhino risks are abundant in construction engineering projects and that there are mutual eliciting relationships between them, which make it difficult for the manager to devote enough resources to the prevention of key risks. Considerable resources are wasted on unimportant risks, resulting in key risk occurrence and failure of construction engineering projects. Therefore, this study describes an innovative multi-criteria decision making (MCDM) technique for ranking risks based on the strength of the eliciting relationships between them. This study used the fuzzy technique and created an interference fuzzy analytical network process (IF-ANP) method. By employing the IF-ANP alongside a decision-making trial and evaluation laboratory (DEMATEL) approach, the subjectivity can be effectively reduced and the accuracy improved during expert risk evaluation for construction engineering projects. IF-ANP was used to quantify eliciting relationships between risks and DEMATEL was used to rank risks based on the IF-ANP result. An empirical study was done to meticulously rank five risks that were selected from the gray rhino risks in the Chengdu–Chongqing Middle Line High-speed Railway construction engineering project. They are capital chain rupture, decision failure, policy and legal risk, economic downturn, and stakeholder conflict. The results showed that the policy and legal risk was the source of other risks, and that these other risks were symptoms rather than the disease.

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Walker, Eloise M., Alice E. Jasper, Lauren Davis, Kay Por Yip, Aduragbemi A. Faniyi, Michael J. Hughes, Helena A. Crisford, et al. "Mitigating Health Risks to Reopen a Clinical Research Laboratory During the COVID-19 Pandemic: A Framework." JMIR Research Protocols 9, no. 12 (December 4, 2020): e22570. http://dx.doi.org/10.2196/22570.

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Background The COVID-19 pandemic has led to many countries implementing lockdown procedures, resulting in the suspension of laboratory research. With lockdown measures now easing in some areas, many laboratories are preparing to reopen. This is particularly challenging for clinical research laboratories due to the dual risk of patient samples carrying the virus that causes COVID-19, SARS-CoV-2, and the risk to patients being exposed to research staff during clinical sampling. To date, no confirmed transmission of the virus has been confirmed within a laboratory setting; however, operating processes and procedures should be adapted to ensure safe working of samples of positive, negative, or unknown COVID-19 status. Objective In this paper, we propose a framework for reopening a clinical research laboratory and resuming operations with the aim to maximize research capacity while minimizing the risk to research participants and staff. Methods This framework was developed by consensus among experienced laboratory staff who have prepared to reopen a clinical research laboratory. Results Multiple aspects need to be considered to reopen a clinical laboratory. We describe our process to stratify projects by risk, including assessment of donor risk and COVID-19 clinical status, the COVID-19 status of the specific sample type, and how to safely process each sample type. We describe methods to prepare the laboratory for safe working including maintaining social distancing through signage, one-way systems and access arrangements for staff and patients, limiting staff numbers on site and encouraging home working for all nonlaboratory tasks including data analysis and writing. Shared equipment usage was made safe by adapting booking systems to allow for the deployment of cleaning protocols. All risk assessments and standard operating procedures were rewritten and approved by local committees, and staff training was initiated to ensure compliance. Conclusions Laboratories can adopt and adapt this framework to expedite reopening a clinical laboratory during the current COVID-19 pandemic while mitigating the risk to research participants and staff.

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