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Journal articles on the topic 'Lab on a chip'

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Published: 4 June 2021
Last updated: 10 March 2023

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1

Holding, Cathy. "Lab on a chip." Genome Biology 4 (2004): spotlight—20040316–01. http://dx.doi.org/10.1186/gb-spotlight-20040316-01.

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2

Drese, Klaus S. "„Lab on a Chip“." Der Internist 60, no. 4 (November 30, 2018): 339–44. http://dx.doi.org/10.1007/s00108-018-0526-y.

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3

Daw, Rosamund, and Joshua Finkelstein. "Lab on a chip." Nature 442, no. 7101 (July 2006): 367. http://dx.doi.org/10.1038/442367a.

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4

Drese, Klaus S. "„Lab on a Chip“." Wiener klinisches Magazin 22, no. 4 (April 9, 2019): 172–77. http://dx.doi.org/10.1007/s00740-019-0286-x.

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5

Friedrich, M. J. "Lab-on-a-Chip." JAMA 306, no. 11 (September 21, 2011): 1191. http://dx.doi.org/10.1001/jama.2011.1308.

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6

Mohammed, Mazher Iqbal. "A lab-on-a-chip that takes the chip out of the lab." Nature 605, no. 7910 (May 18, 2022): 429–30. http://dx.doi.org/10.1038/d41586-022-01299-6.

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7

Laurell, Thomas, and Jörg P. Kutter. "Lab on a Chip: Scandinavia." Lab on a Chip 12, no. 22 (2012): 4601. http://dx.doi.org/10.1039/c2lc90114e.

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8

Graham, Eleanor A. M. "Lab-on-a-Chip Technology." Forensic Science, Medicine, and Pathology 1, no. 3 (2005): 221–24. http://dx.doi.org/10.1385/fsmp:1:3:221.

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9

Herrmann, Sigrun, and Winfried Vonau. "Online-Analyse mit Lab-on-Chip-Systemen (Online Analysis with Lab-on-Chip Systems)." tm - Technisches Messen 71, no. 11-2004 (November 2004): 613–18. http://dx.doi.org/10.1524/teme.71.11.613.51380.

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10

Miner, Gary. "Sensicore's Lab-on-Chip Water Profiler Automates Lab Functions." Journal - American Water Works Association 98, no. 7 (July 2006): 46–48. http://dx.doi.org/10.1002/j.1551-8833.2006.tb07705.x.

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11

Ha, Jae Baek, Jaewoon Jeong, Jeongyoon Suh, Sungyun Park, Ruei Ting Wang, Taewoo Kim, Ji Eun Koh, Jong Hyun Tae, In Ho Chang, and Se Young Choi. "Artificial Intelligence on Urology Lab." Korean Journal of Urological Oncology 20, no. 3 (August 31, 2022): 163–76. http://dx.doi.org/10.22465/kjuo.2022.20.3.163.

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The development of lab-on-a-chip technology based on microfluidics has been used from diagnostic test to drug screening in biomedical science. Lab-on-a-chip technology is also being expanded to the concept of an organ-on-a-chip with the development of cell biology and biocompatible material development. In addition, artificial intelligence (AI) has brought dramatic changes over the past few years in science, industry, defense, science and healthcare. AI-generated output is beginning to prove comparable or even superior to that of human experts. Lab-on-a-chip technology in specific microfluidic devices can overcome the above bottlenecks as a platform for building and implementing AI in a large-scale, cost-effective, high-throughput, automated and multiplexed manner. This platform, high-throughput imaging, becomes an important tool because it can generate high-content information which are too complex to analyze with conventional computational tools. In addition to the capabilities of a data provider, lab-on-a-chip technology can also be leveraged to enable AI developed for the accurate identification, characterization, classification and prediction of objects in heterogeneous samples. AI will provide quantitative and qualitative analysis results close to human in the urology field with lab-on-a-chip.
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12

Mohammed, Mazher Iqbal, Steven Haswell, and Ian Gibson. "Lab-on-a-chip or Chip-in-a-lab: Challenges of Commercialization Lost in Translation." Procedia Technology 20 (2015): 54–59. http://dx.doi.org/10.1016/j.protcy.2015.07.010.

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13

Neužil, P., C. D. M. Campos, C. C. Wong, J. B. W. Soon, J. Reboud, and A. Manz. "From chip-in-a-lab to lab-on-a-chip: towards a single handheld electronic system for multiple application-specific lab-on-a-chip (ASLOC)." Lab Chip 14, no. 13 (2014): 2168–76. http://dx.doi.org/10.1039/c4lc00310a.

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14

Ooi, Chin Hong, Raja Vadivelu, Jing Jin, Kamalalayam Rajan Sreejith, Pradip Singha, Nhat-Khuong Nguyen, and Nam-Trung Nguyen. "Correction: Liquid marble-based digital microfluidics – fundamentals and applications." Lab on a Chip 21, no. 7 (2021): 1418. http://dx.doi.org/10.1039/d1lc90031e.

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15

Daim, Tugrul U., and Pattharaporn Suntharasaj. "Technology Roadmap: Lab-on-a-Chip." Revista de Administração da UFSM 3, no. 1 (November 12, 2010): 160–73. http://dx.doi.org/10.5902/198346592246.

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16

Kim, Khae Hawn. "Lab-on-a-chip for Urology." International Neurourology Journal 17, no. 1 (2013): 1. http://dx.doi.org/10.5213/inj.2013.17.1.1.

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17

Chiou, Eric P. Y., Aaron T. Ohta, Zhihong Li, and Steven T. Wereley. "Optofluidics for Lab-on-a-Chip." Advances in OptoElectronics 2012 (March 19, 2012): 1–2. http://dx.doi.org/10.1155/2012/935325.

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18

Choi, Charles Q. "Big Lab on a Tiny Chip." Scientific American 297, no. 4 (October 2007): 100–103. http://dx.doi.org/10.1038/scientificamerican1007-100.

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19

Nestorova, Gergana G., Varun L. Kopparthy, Niel D. Crews, and Eric J. Guilbeau. "Thermoelectric lab-on-a-chip ELISA." Analytical Methods 7, no. 5 (2015): 2055–63. http://dx.doi.org/10.1039/c4ay02764g.

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Thermoelectric lab-on-a-chip ELISA is a novel method performing immunoassays by measuring the heat of the enzymatic reaction between enzyme-linked detection antibody and a substrate using a thin-film thermopile.
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20

Aldhous, Peter, and David Swinbanks. "Toshiba sets up UK chip lab." Nature 348, no. 6303 (December 1990): 666. http://dx.doi.org/10.1038/348666a0.

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21

García, Miguel, Jahir Orozco, Maria Guix, Wei Gao, Sirilak Sattayasamitsathit, Alberto Escarpa, Arben Merkoçi, and Joseph Wang. "Micromotor-based lab-on-chip immunoassays." Nanoscale 5, no. 4 (2013): 1325–31. http://dx.doi.org/10.1039/c2nr32400h.

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22

Beebe, David J. "Future of lab on a chip." Biomedical Engineering Letters 2, no. 2 (June 2012): 71. http://dx.doi.org/10.1007/s13534-012-0054-y.

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23

Karayannis, Panagiotis, Fotini Petrakli, Anastasia Gkika, and Elias P. Koumoulos. "3D-Printed Lab-on-a-Chip Diagnostic Systems-Developing a Safe-by-Design Manufacturing Approach." Micromachines 10, no. 12 (November 28, 2019): 825. http://dx.doi.org/10.3390/mi10120825.

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The aim of this study is to provide a detailed strategy for Safe-by-Design (SbD) 3D-printed lab-on-a-chip (LOC) device manufacturing, using Fused Filament Fabrication (FFF) technology. First, the applicability of FFF in lab-on-a-chip device development is briefly discussed. Subsequently, a methodology to categorize, identify and implement SbD measures for FFF is suggested. Furthermore, the most crucial health risks involved in FFF processes are examined, placing the focus on the examination of ultrafine particle (UFP) and Volatile Organic Compound (VOC) emission hazards. Thus, a SbD scheme for lab-on-a-chip manufacturing is provided, while also taking into account process optimization for obtaining satisfactory printed LOC quality. This work can serve as a guideline for the effective application of FFF technology for lab-on-a-chip manufacturing through the safest applicable way, towards a continuous effort to support sustainable development of lab-on-a-chip devices through cost-effective means.
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24

Kim, Young Jae, Jae Hyun Lim, Jong Min Lee, Ji Wook Choi, Hyung Woo Choi, Won Ho Seo, Kyoung G. Lee, Seok Jae Lee, and Bong Geun Chung. "CuS/rGO-PEG Nanocomposites for Photothermal Bonding of PMMA-Based Plastic Lab-on-a-Chip." Nanomaterials 11, no. 1 (January 12, 2021): 176. http://dx.doi.org/10.3390/nano11010176.

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We developed copper sulfide (CuS)/reduced graphene oxide (rGO)-poly (ethylene glycol) (PEG) nanocomposites for photothermal bonding of a polymethyl methacrylate (PMMA)-based plastic lab-on-a-chip. The noncontact photothermal bonding of PMMA-based plastic labs-on-chip plays an important role in improving the stability and adhesion at a high-temperature as well as minimizing the solution leakage from microchannels when connecting two microfluidic devices. The CuS/rGO-PEG nanocomposites were used to bond a PMMA-based plastic lab-on-a-chip in a short time with a high photothermal effect by a near-infrared (NIR) laser irradiation. After the thermal bonding process, a gap was not generated in the PMMA-based plastic lab-on-a-chip due to the low viscosity and density of the CuS/rGO-PEG nanocomposites. We also evaluated the physical and mechanical properties after the thermal bonding process, showing that there was no solution leakage in PMMA-based plastic lab-on-a-chip during polymerase chain reaction (PCR) thermal cycles. Therefore, the CuS/rGO-PEG nanocomposite could be a potentially useful nanomaterial for non-contact photothermal bonding between the interfaces of plastic module lab-on-a-chip.
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25

Ehrenman, Gayle. "Shrinking the Lab down to Size." Mechanical Engineering 126, no. 05 (May 1, 2004): 26–29. http://dx.doi.org/10.1115/1.2004-may-1.

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This chapter discusses a lab-on-a-chip, which is used to describe chemical analysis devices that operate on a nanoscale. A chip can perform sensitive, selective chemical analysis in one small package, rather than on multiple pieces of equipment spread across a laboratory bench. In essence, they are shrinking bench-scale biochemical and cell-based assays down to a nano size. Since the chips are working with such small volumes of fluids—a matter of picoliters, in many cases—they are able to provide complex analyses quicker and more economically than is possible using standard lab technology. The lab-on-a-chip testing also generates higher quality data, because there is less human intervention, and the testing is done in a sealed environment that’s less subject to contamination. Lab-on-a- chip technology is being touted for everything from the detection of airborne bioterrorism agents to DNA testing to drug discovery. Much of the technology is still in development, but some commercial applications are already on the market.
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26

Isozaki, Akihiro, Jeffrey Harmon, Yuqi Zhou, Shuai Li, Yuta Nakagawa, Mika Hayashi, Hideharu Mikami, Cheng Lei, and Keisuke Goda. "AI on a chip." Lab on a Chip 20, no. 17 (2020): 3074–90. http://dx.doi.org/10.1039/d0lc00521e.

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27

Badawy, Wael, and Yehya Ghallab. "On-chip Electrical Field Sensing for Lab-on-a-Chip Applications." ECS Transactions 1, no. 28 (December 21, 2019): 1–15. http://dx.doi.org/10.1149/1.2209370.

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28

Nakajima, Mitsutoshi. "Comment on “Robust scalable high throughput production of monodisperse drops” by E. Amstad, M. Chemama, M. Eggersdorfer, L. R. Arriaga, M. P. Brenner and D. A. Weitz, Lab Chip, 2016, 16, 4163." Lab on a Chip 17, no. 13 (2017): 2330–31. http://dx.doi.org/10.1039/c7lc00181a.

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This comment on an article that appeared in Lab on a Chip (Amstad et al., Lab Chip, 2016, 16, 4163–4172) provides information on the performance of microchannel (step) emulsification devices developed by the Nakajima Group.
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29

MIZUTA, Yoshihiro, and Kozo TAGUCHI. "Lab-on-Chip System Combined Optical Tweezers and Dielectrophoresis." Journal of the Japan Society of Applied Electromagnetics and Mechanics 23, no. 3 (2015): 579–84. http://dx.doi.org/10.14243/jsaem.23.579.

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30

Figurova, Maria, Peter Gaso, and Dusan Pudis. "Micro-Optics for Lab-on-a-Chip." Communications - Scientific letters of the University of Zilina 19, no. 3 (September 30, 2017): 30–33. http://dx.doi.org/10.26552/com.c.2017.3.30-33.

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31

Becker, Holger. "Lab-on-a-Chip European Congress 2010." Expert Opinion on Drug Discovery 5, no. 9 (June 23, 2010): 903–5. http://dx.doi.org/10.1517/17460441.2010.502933.

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32

Igata, E., M. Arundell, H. Morgan, and J. M. Cooper. "Interconnected reversible lab-on-a-chip technology." Lab on a Chip 2, no. 2 (2002): 65. http://dx.doi.org/10.1039/b200928p.

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33

Snider, Janice. "SECOND-GENERATION ‘LAB ON A CHIP' DEVELOPED." Journal of the American Dental Association 137, no. 10 (October 2006): 1373–74. http://dx.doi.org/10.14219/jada.archive.2006.0044.

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34

Whitesides, George. "The lab finally comes to the chip!" Lab on a Chip 14, no. 17 (July 21, 2014): 3125. http://dx.doi.org/10.1039/c4lc90072c.

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35

Fair, Richard B. "What is a lab-on-a-chip?" ACM SIGDA Newsletter 38, no. 12 (June 15, 2008): 1. http://dx.doi.org/10.1145/1862834.1862835.

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36

Fair, Richard B. "What is a lab-on-a-chip?" ACM SIGDA Newsletter 38, no. 13 (July 2008): 1. http://dx.doi.org/10.1145/1862837.1862838.

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37

Conde, João Pedro, Narayanan Madaboosi, Ruben R. G. Soares, João Tiago S. Fernandes, Pedro Novo, Geraud Moulas, and Virginia Chu. "Lab-on-chip systems for integrated bioanalyses." Essays in Biochemistry 60, no. 1 (June 30, 2016): 121–31. http://dx.doi.org/10.1042/ebc20150013.

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Biomolecular detection systems based on microfluidics are often called lab-on-chip systems. To fully benefit from the miniaturization resulting from microfluidics, one aims to develop ‘from sample-to-answer’ analytical systems, in which the input is a raw or minimally processed biological, food/feed or environmental sample and the output is a quantitative or qualitative assessment of one or more analytes of interest. In general, such systems will require the integration of several steps or operations to perform their function. This review will discuss these stages of operation, including fluidic handling, which assures that the desired fluid arrives at a specific location at the right time and under the appropriate flow conditions; molecular recognition, which allows the capture of specific analytes at precise locations on the chip; transduction of the molecular recognition event into a measurable signal; sample preparation upstream from analyte capture; and signal amplification procedures to increase sensitivity. Seamless integration of the different stages is required to achieve a point-of-care/point-of-use lab-on-chip device that allows analyte detection at the relevant sensitivity ranges, with a competitive analysis time and cost.
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38

Ensslin, Klaus, Simon Gustavsson, Urszula Gasser, Bruno Küng, and Thomas Ihn. "A quantum mechanics lab on a chip." Lab on a Chip 10, no. 17 (2010): 2199. http://dx.doi.org/10.1039/c003765f.

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39

Mouradian, Stephane. "Lab-on-a-chip: applications in proteomics." Current Opinion in Chemical Biology 6, no. 1 (February 2002): 51–56. http://dx.doi.org/10.1016/s1367-5931(01)00280-0.

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40

Medina-Sánchez, Mariana, Sandrine Miserere, and Arben Merkoçi. "Nanomaterials and lab-on-a-chip technologies." Lab on a Chip 12, no. 11 (2012): 1932. http://dx.doi.org/10.1039/c2lc40063d.

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41

Roberts, Josh P. "Modern Microfluidics via Lab-on-a-Chip." Genetic Engineering & Biotechnology News 33, no. 20 (November 15, 2013): 14, 16. http://dx.doi.org/10.1089/gen.33.20.07.

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42

Weigl, Bernhard H., Ron L. Bardell, and Catherine R. Cabrera. "Lab-on-a-chip for drug development." Advanced Drug Delivery Reviews 55, no. 3 (February 2003): 349–77. http://dx.doi.org/10.1016/s0169-409x(02)00223-5.

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43

WILSON, ELIZABETH. "LAB-ON-A-CHIP FOR PLANETS, MOONS." Chemical & Engineering News Archive 89, no. 43 (October 24, 2011): 8. http://dx.doi.org/10.1021/cen-v089n043.p008a.

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44

Lim, Y. C., A. Z. Kouzani, and W. Duan. "Lab-on-a-chip: a component view." Microsystem Technologies 16, no. 12 (September 18, 2010): 1995–2015. http://dx.doi.org/10.1007/s00542-010-1141-6.

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45

Kovarik, Michelle L., and Stephen C. Jacobson. "Nanofluidics in Lab-on-a-Chip Devices." Analytical Chemistry 81, no. 17 (September 2009): 7133–40. http://dx.doi.org/10.1021/ac900614k.

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46

Miclea, M., K. Kunze, J. Franzke, and K. Niemax. "Plasmas for lab-on-the-chip applications." Spectrochimica Acta Part B: Atomic Spectroscopy 57, no. 10 (October 2002): 1585–92. http://dx.doi.org/10.1016/s0584-8547(02)00067-8.

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47

Huang, Jian-An, Yong-Lai Zhang, Hong Ding, and Hong-Bo Sun. "SERS-Enabled Lab-on-a-Chip Systems." Advanced Optical Materials 3, no. 5 (January 23, 2015): 618–33. http://dx.doi.org/10.1002/adom.201400534.

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48

Truesdell, Sharon L., Estee L. George, and Marnie M. Saunders. "Cellular considerations for optimizing bone cell culture and remodeling in a lab-on-a-chip platform." BioTechniques 68, no. 5 (May 2020): 263–69. http://dx.doi.org/10.2144/btn-2019-0115.

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Our lab has developed a lab-on-a-chip platform for bone remodeling that enables long-term culturing of bone cells out to 7 weeks and serves as a foundation toward a multicellular organ-on-a-chip system. Here, we optimized culturing protocols for osteoblasts, osteoclasts and osteocytes within the lab-on-a-chip and performed functional activity assays for quantifying bone formation and resorption. We analyzed cell seeding densities, feeding schedules and time in culture as a basis for optimizing culturing protocols. Further, we addressed concerns of sterility, cytotoxicity and leakage during the extended culture period within the polydimethylsiloxane chip. This system provides a method for quantifying the soluble effects of mechanically stimulated osteocytes on bone remodeling (formation/resorption).
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49

Gambari, Roberto, Monica Borgatti, Luigi Altomare, Nicolo Manaresi, Gianni Medoro, Aldo Romani, Marco Tartagni, and Roberto Guerrieri. "Applications to Cancer Research of “Lab-on-a-chip” Devices Based on Dielectrophoresis (DEP)." Technology in Cancer Research & Treatment 2, no. 1 (February 2003): 31–39. http://dx.doi.org/10.1177/153303460300200105.

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The recent development of advanced analytical and bioseparation methodologies based on microarrays and biosensors is one of the strategic objectives of the so-called post-genomic. In this field, the development of microfabricated devices could bring new opportunities in several application fields, such as predictive oncology, diagnostics and anti-tumor drug research. The so called “Laboratory-on-a-chip technology”, involving miniaturisation of analytical procedures, is expected to enable highly complex laboratory testing to move from the central laboratory into non-laboratory settings. The main advantages of Lab-on-a-chip devices are integration of multiple steps of different analytical procedures, large variety of applications, sub-microliter consumption of reagents and samples, and portability. One of the requirement for new generation Lab-on-a-chip devices is the possibility to be independent from additional preparative/analytical instruments. Ideally, Lab-on-a-chip devices should be able to perform with high efficiency and reproducibility both actuating and sensing procedures. In this review, we discuss applications of dielectrophoretic(DEP)-based Lab-on-a-chip devices to cancer research. The theory of dielectrophoresis as well as the description of several devices, based on spiral-shaped, parallel and arrayed electrodes are here presented. In addition, in this review we describe manipulation of cancer cells using advanced DEP-based Lab-on-a-chip devices in the absence of fluid flow and with the integration of both actuating and sensing procedures.
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50

Temiz, Yuksel, Robert D. Lovchik, Govind V. Kaigala, and Emmanuel Delamarche. "Lab-on-a-chip devices: How to close and plug the lab?" Microelectronic Engineering 132 (January 2015): 156–75. http://dx.doi.org/10.1016/j.mee.2014.10.013.

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