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Yeung, Shuk Yin. "Pharmacological study of fluoxetine and BDS toxins on central Kv1 and Kv3 channel subfamily members." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415328.
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Rashid, Asim J. "Contribution of Kv3 potassium channels to signal processing by electrosensory neurons." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38513.
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Gamma-frequency burst discharge in pyramidal cells of the apteronotid electrosensory lateral line lobe (ELL) is necessary for signal processing. Bursting is dependent on an interaction between somatic and apical dendritic currents, in which spike broadening in the apical dendrite potentiates a somatic afterpotential that follows each rapid somatic spike. Somatic spike repolarization must be consistent in order for the afterpotential to be expressed soon after. The work presented in this thesis describes how the expression and differential subcellular distribution of two Kv3-type K+ channels in ELL pyramidal cells may contribute to this mechanism of burst discharge.I cloned a family of Kv3 channels from an apteronotid brain cDNA library and demonstrated that two of these channels, homologues of the mammalian subtypes Kv3.1 and Kv3.3, are expressed in ELL pyramidal cells. Immunohistochemical analysis demonstrated that the AptKv3.3 K+ channel is distributed throughout the dendrites of pyramidal cells while the AptKv3.1 channel is restricted in its expression to pyramidal cell somata, basilar dendrites and proximal apical dendrites. Heterologous expression of each channel in HEK 293 cells indicated that AptKv3.3 encodes a high-threshold inactivating K + current while AptKv3.1 encodes a high-threshold K+ current which does not display inactivation upon prolonged membrane depolarization. Based on these results as well as pharmacological analysis of native ELL pyramidal cells, I propose that AptKv3.3 mediates spike repolarization in the apical dendrite and inactivation of the channel during repetitive firing allows spike broadening. In contrast, AptKv3.1 likely contributes towards rapid and consistent spike repolarization in the cell soma. Therefore, the expression and differential distribution of these two Kv3 channels in ELL pyramidal cells may underlie the compartmental differences in spike repolarzation that is necessary for burst discharge.
The extensive dendritic localization of AptKv3.3 observed in ELL pyramidal cells as well as in other hindbrain neurons has not previously been demonstrated for members of the Kv3 family of K+ channels. The differential localization of AptKv3.1. AptKv3.3 and possibly AptKv3.3 splice variants that I have identified presents an opportunity to examine the molecular mechanisms of Kv3 channel targeting in neurons. Preliminary data is presented which provides the foundation for future studies on channel targeting.
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Illy, Marcus [Verfasser], and Peter [Akademischer Betreuer] Jonas. "Functional role of presynaptic Kv3 channels on synaptic transmission at the basket cell-granule cell synapse = Die funktionelle Aufgabe von präsynaptischen Kv3 Kanälen bei der synaptischen Transmission an der Korbzell-Körnerzell Synapse." Freiburg : Universität, 2012. http://d-nb.info/1123470928/34.
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Baier, Julia [Verfasser], Tobias [Akademischer Betreuer] Huth, and Christian [Gutachter] Alzheimer. "Untersuchung der Oberflächenexpression von Kv3-Kanalkomplexen im Zusammenhang mit der beta-Sekretase BACE1. / Julia Baier ; Gutachter: Christian Alzheimer ; Betreuer: Tobias Huth." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2021. http://d-nb.info/1238358446/34.
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El, Haou Saïd. "Régulation des canaux potassiques cardiaques par la protéine d'accrochage SAP97." Paris 6, 2009. http://www.theses.fr/2009PA066258.
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Les canaux ioniques sont des protéines enchâssées dans la membrane cellulaire responsables de l’activité électrique, notamment au niveau cardiaque. Ces canaux sont constitués du pore canalaire mais également de nombreuses protéines partenaires. Parmi ces protéines partenaires les protéines MAGUK (Membrane Associated Guanlytate Kinase) apparaissent comme étant des éléments essentiels au bon fonctionnement des canaux ioniques cardiaques. Dans cette étude, nous avons examiné le rôle de la protéine MAGUK appelée SAP97 (Synapse Associated Protein) sur divers canaux potassiques cardiaques responsables de la repolarisation du myocarde. Nos résultats ont montré que la SAP97 régule l’expression membranaire de ces canaux dans les myocytes cardiaques. De plus, nous avons montré que la SAP97 participe à la formation d’un complexe tripartite entre les canaux Kv4 et la CaMKII. L’ensemble de ces travaux a permis de montrer les protéines MAGUK joueraient un rôle majeur dans l’organisation de complexes permettant l’organisation et le couplage de l’activité électrique avec la signalisation intracellulaire.
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Sparrenbom, Charlotte Jönsson. "Constraining the southern part of the Greenland Ice Sheet since the Last Glacial Maximum from relative sea-level changes, cosmogenic dates and glacial-isostatic adjustment models." Lund : Department of Geology, GeoBiosphere Science Centre, Lund University, 2006. http://www.geol.lu.se/kvg/avhandlingar/cs_kappa.pdf.
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Tur, Jared. "Cardiovascular regulation by Kvβ1.1 subunit." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6596.
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Heterologous expression systems such as COS-7 cells have demonstrated the profound effects of KCNAB1-3 or Kvβ1-3 proteins on voltage gated potassium channels (Kv) channels. Indeed, in the presence of these β-subunits transiently expressed Kv channels are often modulated in multiple ways. Kv channel membrane expression is often increased in the presence of β-subunits. In addition, non-inactivating Kv currents suddenly become fast-inactivating and fast-inactivating channels become even faster. While much research has demonstrated the profound effects the β-subunits in particular the Kvβ1 subunit have on transiently expressed Kv currents little to date is known of the physiological role it may play. One study demonstrated that by “knocking out” Kvβ1 cardiomyocyte current changes were noted including a decrease in the Ito,f current. While this novel finding demonstrated a key cardiac physiological role of the Kvβ1 subunit it left many unanswered questions as to determine the cardiovascular regulation the Kvβ1 subunit provides. Indeed, cardiac arrhythmias and other electrical abnormalities within the heart such as long QT present patients with many unfortunate unknowns. Many of these incidences occur often abruptly with cardiac electrical abnormalities. Genetic research has begun to shine light on key cardiovascular genes in particular those coding for ion channels and auxiliary subunits or β-subunits. Kv channels and their β-subunits have gained particular notoriety in their key responsibility in restoring the resting membrane potential known as the repolarization phase. Indeed genetic manipulation and physiological examination of Kv channels and recently their β-subunits has demonstrated profound physiological results including prolonged QT durations within mice altered functional activity during physiological cycles such as estrus. While initial findings of Kvβ1 have demonstrated profound cellular and cardiomyocyte current alterations much still remains unknown. Therefore, this work hypothesizes that the Kvβ1 subunit provides a profound cardiovascular role in regulation and redox sensing at the physiological and pathophysiological level in both males and females. This work identifies a sex-based difference in cardiovascular regulation by Kvβ1 as well as demonstrated a profound redox sensing ability during altered metabolic states seen in pathophysiological conditions.
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Andersson, Carl Fredrik. "50 kVA eller 100 kVA : En teknisk och ekonomisk jämförelse av distributionstransformatorer." Thesis, Högskolan Väst, Institutionen för ingenjörsvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-2730.
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Rapporten utreder om distributionstransformatorer med märkeffekten 50 kVA i Vattenfall Eldistribution AB:s elnät kan avskaffas till förmån för märkeffekten 100 kVA. Transformatorer med märkeffekten 50 kVA förekommer vid nedtransformering av spänningen från 22 kV och 11 kV till hushållens huvudspänning 0,4 kV. 50 kVA-transformatorer skiljer inte särskilt mycket från transformatorer med den högre märkeffekten i fråga om storlek och pris, och de bedöms kunna bytas ut utan större praktiska svårigheter. Fördelen med 100 kVA är att de elektriska belastningsförlusterna blir lägre i och med den högre märkeffekten. Dessutom innebär ett byte vissa elkvalitetsförbättringar. Nackdelarna med 100 kVA är att de elektriska tomgångsförlusterna är högre och att inköpspriset är högre än för 50 kVA. I övrigt kan kostnaderna likställas för de två alternativen. Endast kostnader för aktiva effektförluster berördes i rapporten då de ekonomiska kostnaderna för reaktiva effektförluster kunde försummas för de aktuella transformatorerna. För att nå ett svar på frågan om det kan vara lönsamt att avskaffa 50 kVA-transformatorerna studerades fem verkliga fall i Vattenfalls svenska elnät. Dessutom studerades eventuella elkvalitetsvinster med ett byte. Svaret blev att inte för något av de fem studerade fallen var det lönsamt med ett byte till 100 kVA-transformator. Rörande elkvalitetsaspekten blev svaret att ett byte visserligen innebär en skillnad men att andra faktorer oftast har större betydelse. Rapportens rekommendation blev att behålla 50 kVA-transformatorn i distributionsnätet.
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Rauber, Daniel Walter. "Die Freizügigkeit nach KVG /." [S.l.] : [s.n.], 1985. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
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Pavlou, Petro. "KVA in Black Scholes Pricing." Master's thesis, Faculty of Commerce, 2019. http://hdl.handle.net/11427/30880.
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The post 2007-financial crisis era has led to renewed zeal in quantifying market incompleteness when pricing contingent claims. This quantification exercise is necessary in maintaining a stable and sustainable banking operation and thus the XVAs have emerged as the metrics for market incompleteness. This dissertation focuses solely on the capital valuation adjustment (KVA) and aims to use the definition of KVA as set out by Albanese et al. (2016) in an investigation of different numerical techniques for calculating KVA. A single equity forward is considered first, followed by an equity option and then portfolios of options on two underlying assets, with the dissertation ending by considering a practical example on discrete delta and vega-delta hedging an index option. The numerical approaches explored are the binomial tree method and a combination of the crude and quasi-Monte Carlo method.
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Kourrich, Saïd. "Rôle des canaux Kv1. 1 et Kv1. 3 au cours des processus mnésiques chez le rat." Aix-Marseille 1, 2001. http://www.theses.fr/2001AIX11037.
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Les expériences rapportées dans ce mémoire avaient pour but d'étudier le rôle des canaux KV1. 1 et KV1. 3 au cours des processus d'apprentissage et de mémoire. Dans la première approche (comportementale), l'effet du blocage de ces canaux par la KTX (10 ng) (en injection icv) a été évalué dans différents protocoles mettant en jeu préférentiellement deux types de mémoire dans une tâche de discrimination olfactive : la mémoire procédurale et la mémoire de référence. Dans les deux types de mémoire étudiée, le blocage de ces canaux par la KTX facilitait l'apprentissage et non la consolidation des informations. Cette toxine facilitait également le rappel à long-terme d'une association odeur-renforcement. Une expérience contrôle en open-field a montré que le blocage des canaux KV1. 1 et KV1. 3 par la KTX n'affectait pas les processus d'attention. La deuxième approche (électrophysiologique) avait pour but d'explorer les éventuels phénomènes de plasticité pouvant sous-tendre la facilitation de l'apprentissage induit par la KTX. Une première expérience, "in vitro" sur tranche d'hippocampe, a montré que la KTX (100 nM) induisait une facilitation synaptique de longue durée vraisemblablement par un mécanisme pré-synaptique au niveau des synapses fibres moussues-CA3. Ce résultat a été ensuite confirmé par une expérience réalisée "in vivo" chez le rat éveillé libre de ses mouvements avec une dose de 10 ng en icv. La troisième approche (histochimique) avait pour but d'observer une éventuelle implication de ces canaux au cours des processus mnésiques. La technique d'hybridation in situ a montré une diminution de l'expression des ARNm KV1. 1 au niveau de l'hippocampe ventral (GD, CA3 et CA1) lorsque les rats étaient sacrifiés 1 heure après la seconde séance d'apprentissage d'une association odeur-renforcement. D'autres variations ont été observées, mais ne semblaient pas être spécifiques du conditionnement.
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Eid, Basma. "The pharmacology & therapeutic potential of Kv7 channels in the pulmonary circulation." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-pharmacology--therapeutic-potential-of-kv7-channels-in-the-pulmonary-circulation(6a9bb4a3-eb2a-4135-91b2-ca598f041f86).html.
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Pulmonary arterial tone is regulated in part by the membrane potential (Em) of pulmonary artery smooth muscle cells (PASMCs). The Kv7 family of K+ channels was recently implicated in regulating Em in rat PASMCs and expression of KCNQ1, KCNQ4 and KCNQ5 mRNA, which encode Kv7 channels, was reported. Kv7 activators were beneficial in two-independent mouse models of pulmonary hypertension (PH), which provides further evidence for their role in regulating pulmonary tone. The goals of this study were to: 1) Elucidate the role of Kv7 channels and Em in the hypertensive pulmonary circulation and 2) Study the effects and mechanism of action of a novel Kv7 modulator, zinc pyrithione (ZnPy) on the pulmonary circulation. PH was induced in male Wistar rats by administering a single 60 µg/kg intraperitoneal injection of monocrotaline (MCT). The effects of Kv7 modulators on hypertensive and control pulmonary arteries (PA) were compared using small-vessel myography. The vasoconstrictor effect of the Kv7 blocker, XE991, was enhanced in MCT PA. The Kv7 activators retigabine and ZnPy showed enhanced efficacy in relaxing MCT PA and suppressed raised intrinsic tone identified in MCT PA relative to control PA. The effects of MCT in responses to Kv7 modulators were pulmonary specific as they were not seen in mesenteric arteries from the same animals. Real-time PCR studies revealed that PA from MCT and control rats showed a similar expression of KCNQ1, KCNQ4 and KCNQ5 mRNA transcripts. I propose that the enhanced effects of Kv7 modulators on PA from MCT rats were due to disease-induced depolarization of PASMCs, which raised intrinsic tone and increased Kv7 channel activation at rest. This is the first evidence that Kv7 channels are functional in this model of PH and may serve as potential drug targets. The effects of ZnPy on PASMCs were studied by patch-clamp electrophysiology. ZnPy consistently hyperpolarized PASMCs and significantly increased the K+ current elicited by a voltage-step from -80 to +40 mV. ZnPy also increased the non-inactivating current recorded at 0 mV in some cells. The effects of ZnPy on Em and K+ currents were inhibited by 10 mM tetraethylammonium (TEA) and 1 µM paxilline but not by 50 nM iberiotoxin. XE991 (10µM) inhibited the ZnPy-induced hyperpolarization without altering its effects on K+ currents, suggesting that the current recorded was not responsible for its effect on Em. When tested on intact vessels, ZnPy consistently produced vasodilation. Its effects were unaffected by TEA, paxilline and iberiotoxin; however, XE991 (100 nM) had an inhibitory effect. The results suggest that ZnPy hyperpolarizes PASMCs by activating a TEA, paxilline and XE991 sensitive, but iberiotoxin insensitive channel, most likely a Kv7 channel. Its ability to dilate PA depended on pharmacologically distinct mechanisms, which are unlikely to involve Kv7 channels.
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Pérez, Verdaguer Mireia. "Deciphering the interaction between Kvl.3 and Caveolin." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/291827.
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The voltage-dependent K+ channel Kv1.3 participates in many physiological events like proliferation and activation of immunitary cells, membrane repolarization in sensory neurons, vascular smooth muscle tone, insulin resistance and obesity. In most cases, Kv1.3 concentrates in specific membrane microdomains called lipid rafts. These domains act as platforms where signaling pathways converge. Caveolae are a specialized form of lipid rafts with an omega shaped structure build up by the structural protein caveolin. These omega shaped structures are present in multiple cell lines and highly abundant in adipocytes where they account for up to 30 % of the plasma membrane surface, where they participate in lipid transport, lipotoxicity protection, mechanic stress protection and cell signaling. Evidence indicates that Kv1.3 functionality relays not only on expression but also on localization at the plasma membrane. The importance of this spatial regulation is manifest when an altered Kv1.3 distribution is related with the appearance of disease. Therefore, the mechanisms that govern Kv1.3 function are of considerable interest. In this study we characterized the relationship between Kv1.3 and caveolins. Thus Kv1.3 interacted mainly with caveolin 1. In addition, we analyzed the presence of putative caveolin-binding domain in Kv1.3 that could explain their interaction. To that end, we performed structure-function studies by using a repertoire of Kv1.3 mutants and stable HEK-293 cell lines with or without caveolins, characterized putative interactions and analyzed membrane dynamics by single molecule tracking. Thus, a CBD appeared in the Nt of the Kv1.3 (close to the T1 domain). This motive was not only involved in Kv1.3-caveolin interaction but also in Kv1.3 forward trafficking. Thus the Kv1.3mutCBD remained trapped in intracellular Golgi-like structures. Even so, the channel remained functional despite some biophysical properties alterations. Moreover, the channel suffered palmitoylation like Kv1.5 but, unlike Kv1.5 it was not the mail lipid raft targeting signal as it was caveolin. 2 palmitoilation sites would be involved in Kv1.3 palmitoylation. C51/52, C267 and C515.
The role of Kv1.3 in adipocytes raises an important debate as it has been proposed that Kv1.3 could be a pharmacological target in obesity. What is more, Kv1.3 (-/-) mice presented a lean phenotype that could suggest the importance of the Kv1.3 in preadipocytes proliferation and differentiation. We have characterized the presence of Kv1.3 in rat, mice and human adipocytes and before and after adipogenesis induction of 3T3-L1 cell line. the adipogenesis induced caveolin 1 expression and a parallel Kv1.3 increase. Since adipogenesis induced both Kv1.3 and caveolin 1 expression and so the appearance of caveolae, we further analyzed the specific localization of Kv1.3. Our results indicate that adipogenesis triggers a relocalization of Kv1.3 in newly synthesized caveolae. Because most of insulin-dependent adipocyte signaling is located in these structures the presence of the channel in caveolae seemed to be important for adipocytes physiology. What is more, the caveolin expression disruption relocated Kv1.3 out of lipid raft caveolae structures. As Kv1.3 is considered an important pharmacological target for different autoimmunitary diseases and obesity, it is important to bring light to the Kv1.3 interactions with other partners that can regulate channel surface distribution and function.El canal de potassi dependent de voltatge Kv1.3 està involucrat en múltiples funcions cel·lulars. Així, el Kv1.3 participa en la fisiologia cel·lular de leucòcits, neurones sensorials, el to de la musculatura llisa vascular, resistència a insulina i obesitat. Part del Kv1.3, que es localitza majoritàriament a la membrana plasmàtica, es distribueix en microdominis lípid raft. Aquests lípid rafts actuen com a plataformes de senyalització on múltiples molècules de senyalització convergeixen per coordinar la resposta cel·lular. Un tipus especialitzat d’aquests microdominis són les caveoles. Estructures amb forma d’omega gràcies a la presència de la proteïna estructural caveolina. Són presents en diversos tipus cel·lulars i especialment abundants en adipòcits on poden suposar fins un 30% de la superfície cel·lular. En aquesta tesi hem estudiat la interacció entre el Kv1.3 i la caveolina en el sistema d’expressió heteròleg HEK 293. Així, ambdues proteïnes interaccionen a través d’un motiu CBD present al Nt del Kv1.3. La disrupció d’aquest domini aboleix la interacció entre ambdues proteïnes i, més enllà, altera el trànsit del canal a través de la ruta secretora. Així, el Kv1.3mutCBD tot i mantenir la capacitat de tetrameritzar queda retingut en estructures intracel3lulars tipus Golgi presumiblement degut a un defecte de N-glicosilació. La interacció entre el Kv1.3 i caveolina va poder ser confirmada en adipòcits. més encara, la depleció de caveolina en adipòcits 3T3-L1 deslocalitza el canal de les caveoles. Més enllà d’intervenir en la localització del canal, la caveolina també canvia l’activitat electrofisiològica del canal. Així, en absència de caveolina el canal presenta una menor densitat de corrent i la seva presència canvia lleugerament les propietats biofísiques del canal, fent més ràpides l’activació i inactivació.
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Oliveras, Martínez Anna. "Cardiovascular Kv7 channels in health and in disease." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/385848.
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Voltage-gated K+ channels, Kv channels, are the most diverse group of K+ channels. They have several key functions in cardiovascular and nervous system; setting the resting membrane potential and controlling the repolarization of the action potential. In non-excitable cells they also play crucial role in water and ion transport across the epithelia or cell volume regulation. Such extraordinary heterogeneity in functions is closely related with a remarkable genetic and structural heterogeneity of Kv channels.
Among Kv channels, the Kv7 family comprises 5 members, Kv7.1-Kv7.5. Like other Kvs, Kv7 channels are tetramers of 4 α subunits. The topological arrangement of every α subunit consists in 6 transmembrane segments: S1-S4 form the voltage sensing domain and the S5-S6 region the ion-selective pore. Kv7 channels use to assemble as homotetramers, but most of the members of the family are also able to form heterotetrameric channels. Heterotetramerization is one of most important mechanisms to achieve the vast functional diversity that they display. Moreover, Kv7 channel function is also influenced by regulatory subunits, the KCNE family. They regulate various gating parameters, current density, channel assembly, ER retention, sorting into different traffic pathways, subcellular localization, regulation of the post-translational modifications or sensibility to pharmacological agents.
In the cardiovascular system, both Kv7.1 and Kv7.5 play a pivotal role. In cardiac myocytes, Kv7.1 homotetramers combine with KCNE1 β subunit to form functional channels. They are the molecular correlate of the IKs current, a slow delayed-rectifier K+ current involved in the repolarization of the cardiac action potential and an important determinant of the duration of the QT interval of the electrocardiogram. Mutation in either, Kv7.1 and KCNE1 result in long QT or short QT syndromes, which can lead to fatal severe arrhythmias. Kv7 have been also recognized to be key regulators of the vascular physiology, setting the resting membrane potential in vascular smooth muscle myocytes and therefore controlling the vascular smooth muscle tone. In particular, Kv7.1, Kv7.4 and Kv7.5 had been detected in numbers of veins and arteries, but the specific contribution of every subunit to physiological relevant K+ currents is still under debate.
Within this scenario, the proposed objectives for the currently discussed PhD dissertation were focused on further study the heteroligomerization process of the Kv7 channel family, either by heterotetramerization or by interaction with β regulatory subunits. In the one hand corroborate the functional assembly of Kv7.1-Kv7.5 heterotetramers in vascular smooth muscle. On the other hand, we were also committed to explore the molecular pathological mechanisms of Kv7.1 mutations linked to cardiac channelopathies as well as dissect the traffic and assembly process of the Kv7.1-KCNE1 complex.
We had been able to prove that Kv7.1-Kv7.5 form heterotetrameric channels in vascular smooth muscle cells. Moreover, upon heterotetramer assembly the special distribution of those channels within plasma membrane microdomains is rearrange and Kv7.1 shifted out of lipid raft structures. In addition, we had studied 2 different mutations in Kv7.1, F279I and D242N, responsible for short QT and long QT syndromes, respectively. Those mutations uncover 2 Kv7.1 residues important for KCNE1 interaction: F279 physically interacts with KCNE1 and D242 is involved in the KCNE1-dependent modulation of the voltage-dependent gating mechanism of the Kv7.1 channel. Furthermore, our results revealed that Kv7.1 and KCNE1 are not assembled in the very first stages of the biosynthetic pathway. On its own, KCNE1 traffics through the classical secretion pathway to the cell surface, in contrast, Kv7.1 takes an unconventional pathway. Upon co-assembly, Kv7.1 redirects KCNE1 to the unconventional pathway that lead to the concentration of both subunits in the endoplasmatic reticulum-plasma membrane junctions, where complexes are assembled.Els canals de potassi dependents de voltatge Kv7.1 i Kv7.5 juguen un paper molt important en la fisiologia del sistema cardiovascular. Aquest canals iònics estan formats per la tetramerització de 4 subunitats α. La heterotetramerizació és un dels mecanisme principals que dona lloc a la immensa diversitat funcional que mostra aquesta família. A més a més, la seva funció també es veu influenciada per la interacció amb subunitats β reguladores de la família KCNE. Tot i ser petits pèptids, els KCNEs poden modular un gran ventall de característiques de la biologia i electrofisiologia de les corrents generades per la família Kv7. En els cardiomiòcits, Kv7.1 interacciona amb KCNE1 per donar lloc el corrent IKs, una important corrent de K+ determinant per la repolarització del potencial d’acció cardíac i per la durada del interval QT de l’electrocardiograma. Mutacions tant en Kv7.1 com en KCNE1 donen lloc a les síndromes de QT llarg i QT curt, totes dues relacionades amb perilloses arítmies i mort sobtada. Kv7.1 juntament amb Kv7.4 i Kv7.5 també participen en el control del to de la musculatura llisa vascular, tot i que el paper específic de cada subunitat en les corrents detectades en aquest teixit encara genera una gran controvèrsia. En la present tesi doctoral demostrem l’existència d’heterotetramers Kv7.1-Kv7.5 en els miòcits de la musculatura llisa vascular. Aquesta nova interacció provoca el desplaçament de Kv7.1 fora dels microdominis de membrana tipus lipid raft. També hem estudiat els mecanismes patològics moleculars de dos mutacions en Kv7.1, F279I i D242N, responsables de les síndromes del QT curt i el QT llarg, respectivament. Aquestes dues mutacions han posat de manifest 2 residus en Kv7.1 importants per la interacció amb KCNE1: F279 participa en la interacció física amb KCNE1 i D242 en la regulació per KCNE1 del mecanisme, depenent de voltatge, d’obertura del canal. Per últim, hem comprovat que Kv7.1 i KCNE1 trafiquen per diferents vies secretores i que la formació dels complexes Kv7.1-KCNE1 té lloc a les unions reticle endoplasmatic-membrana plasmàtica.
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Papakosta, Marianthi. "Structural and functional analysis of KVI K+ channels." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289870.
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SASANK, HYDERKHAN. "Performance analysis of TCP in KVM virtualized environment." Thesis, Blekinge Tekniska Högskola, Institutionen för kommunikationssystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-10793.
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The requirement of high quality services is increasing day by day. So, in order to meet up with this requirement new technologies are being developed one of them being virtualization. The main agenda of introducing virtualization is that though virtualization needs more powerful devices to run the hypervisor, the technique also helps to increase consolidation which makes efficient use of resources like increase in the CPU utilization. The virtualization technique helps us to run more VM’s (Virtual Machine) on the same platform i.e. on the same hypervisor. In virtualization as number of VM’s share the CPU will there be any effect on the performance of TCP with the performance influencing factors of virtualization. While TCP being the most widely used protocol and most reliable protocol can performance of TCP vary if different TCP congestion control mechanism are used in the virtualized environment are the main aims of this research. In this study, we investigate the performance influencing factor of TCP in the virtualized environment and whether those influencing factors have any role to play with the performance of the TCP. Also which TCP congestion control mechanism is best suitable in order to download files when virtualization is used will be investigated by setting up a client-server test bed. The different TCP congestion control mechanism which have been used are CUBIC, BIC, Highspeed, Vegas, Veno, Yeah, Westwood, LP, Scalable, Reno, Hybla. Total download time has been compared in order to know which congestion control algorithm performs better in the virtualized environment. The method that has been used to carry out the research is by experimentation. That is by changing the RAM sizes and CPU cores which are the performance influencing factors in virtualization and then analyzing the total download time while downloading a file by changing the TCP congestion control mechanisms by running a single guest VM. Apart from changing only congestion control mechanisms the other network parameters which effect the performance of the TCP such as Delay have been injected while downloading the file, to match up with the real time scenarios. Results collected include average download time of a file by changing the different memory sizes and different CPU cores. Average Download time for different TCP congestion controls mechanisms with inclusion of the parameter that effects the total download time such as Delay. From the results we got we can see that there is a slight influence on the performance of TCP by the performance influencing factors memory sizes and CPU cores allotted to the VM in the KVM virtualized environment and of all the TCP congestion control algorithms having TCP – BIC and TCP- YEAH performs the best in the KVM virtualized environment. The performance of TCP – LP is the least in the KVM virtualized environment.
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SILVA, Luís Eduardo Tenório. "Análise do impacto do isolamento em ambientes virtuais." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/20267.
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CNPq
O surgimento da virtualização permitiu uma mudança na maneira de pensar em prestação de serviço pela Internet, permitindo assim o surgimento de grandes conceitos como a computação em nuvem. Com o passar do tempo, novas tecnologias que permitem virtualizar recursos foram surgindo e trouxe a tona questões de desempenho, isolamento, entre outras. Analisar o impacto causado pelo mau comportamento das abstrações virtuais pode permitir ao administrador da nuvem tomar uma ação na escolha de uma tecnologia específica de virtualização para minimizar os impactos causados a todo ambiente. Hodiernamente, o isolamento é uma preocupação que remete pesquisas e estudos do seu impacto na qualidade dos serviços prestados em um ambiente virtualizado. Indagar sobre a possibilidade de detecção para tomada de ações com a finalidade de minimizar os impactos decorrentes de interferências devido a um mau isolamento é uma das atividades que vêm sendo estudadas com o passar dos anos. O surgimento de diversas técnicas de virtualização trouxe também preocupações de qual é adequada a qual caso. Alguns dessas técnicas vêm sofrendo melhorias únicas nesses últimos anos, principalmente no que diz respeito ao isolamento e controle de recursos. Nesse contexto, essa dissertação propõe uma estratégia adaptada da literatura (procurando unir técnicas distintas) para observar possíveis indícios de quebra do isolamento de ambientes virtuais e organizar os serviços de determinada natureza na melhor técnica de virtualização, verificando também os resultados apresentados por cada técnica de virtualização existente. Para tanto, é adotada uma metodologia que favorece a concepção dos diversos cenários possíveis a partir de um número de infraestruturas virtuais, ofertando serviços web e utilizando diferentes técnicas de virtualização, observando principalmente os recursos utilizados pelas infraestruturas virtuais e a qualidade do serviço prestado. Concluímos que dependendo do tipo de recurso observado as estratégias de isolamento de uma técnica de virtualização podem ser ou não eficazes.
The rise of virtualization has enabled a shift in thinking in service delivery over the Internet, thus allowing the emergence of major concepts such as cloud computing. Over time, new technologies that enable virtualization resources have emerged and brought up performance issues, performance, insulation, etc. Analyze the impact of the bad behavior of virtual abstractions can enable the cloud administrator take an action in choosing a specific virtualization technology to minimize impacts to the whole environment. Nowadays, isolation is a concern that brings research and studies its impact on the quality of services in a virtualized environment. Investigate about the possibility of detection for taking actions in order to minimize the impacts of interference due to poor isolation, it is one of the activities that have been studied over the years. The emergence of various virtualization techniques also brought concerns the kind which is suitable case. Some of these techniques have improved in recent years, especially with regard to isolation and control features. In this context, this work proposes an adapted strategy literature (seeking to unite different techniques) to observe possible break indications isolation of virtual environments and organize the particular nature services in the best virtualization technique, also checking the results presented for each technique existing virtualization. Therefore, a methodology that favors the design of the various possible scenarios constructed from a number of virtual infrastructures offering web services and using different virtualization techniques is adopted, especially noting the resources used by the virtual infrastructure and the quality of service. We conclude that depending on the type of resource noted the isolation strategies of a virtualization technique can be effective or not.
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Outadi, Siavash, and Jana Trchalikova. "Performance comparison of KVM and XEN for telecommunication services." Thesis, Blekinge Tekniska Högskola, Institutionen för datalogi och datorsystemteknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2552.
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High stability of telecommunication services has a positive e ect on customer satisfaction and thus helps to maintain competitiveness of the product in telecommunication market. Since live migration provides a minimal down- time of virtual machines, it is deployed by telecommunication companies to ensure high availability of services and to prevent service interruptions. The main objective of this research is to assess the performance of various hypervisors in terms of live migration and determine which of them best meets the criteria given by a telecommunication company. Response time and CPU utilization of telecommunication services are measured in non- virtualized and virtualized environments to better understand the impacts of virtualization on the services. Two hypervisors, i.e. KVM and XEN, are used to grasp their characteristic behaviour of handling the services. Furthermore, performance of live migration is assessed for both hypervisors using miscellaneous test cases to identify which one has the best overall performance in terms of downtime and total migration time.
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Ugolini, Matteo. "K3 surfaces." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18774/.
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Zhubi, Adrian, and Albert Zhubi. "K2 eller K3 : Motiv till att redovisa enligt K3." Thesis, Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-31544.
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Titel: K2 eller K3 : Motiv till att redovisa enligt K3 Författare: Adrian Zhubi och Albert Zhubi Färdigställt: Våren 2016 Handledare: Eva Berggren Bakgrund: BFN har sedan 2004 gett ut allmänna råd, vilket har medfört att K-projektet skapats där företag delas in i fyra olika kategorier beroende på företagsstorlek. K-projektets vanligaste regelverk är huvudregelverket principbaserade K3 och alternativregelverket regelbaserade K2. Sedan 2015 är det obligatoriskt för samtliga aktiebolag och ekonomiska föreningar att tillämpa ett av dessa två regelverk. Företag bör därmed reflektera över dess verksamhet och intressenter vid val av regelverk. Valet kan ställa krav på att årsredovisningen ska vara relevant för intressenter. Vi vill därför med studien undersöka vilka väsentliga skillnader som förklarar att företag väljer K3 framför K2. Detta utifrån redovisningsrådgivares perspektiv. Syfte: Syftet med studien är att förklara vilka skillnader som ligger bakom att företag föredrar K3 istället för K2 utifrån redovisningsrådgivares perspektiv. Problemformulering: Vad anser redovisningsrådgivare förklarar företags val av K3 framför K2? Metod: Studien består av en kvalitativ ansats. Den empiriska datan består av totalt fem intervjuer, varav en är pilotintervju. Studiens respondenter består av tre revisorer, en redovisningsexpert samt en redovisningsspecialist. Respondenterna har olika erfarenheter och är från olika revisionsbyråer. Resultat: Studien visar att redovisningsrådgivare anser skillnader i materiella, immateriella och finanisella anläggningstillgångar i K2 och K3 gör att företag föredrar K3. Avsättningar, uppskjuten skatt och intressenter är även påverkande faktorer. Samtliga respondenter var eniga om att K2 är enklare att tillämpa då regelverket innehåller handfasta regler för redovisning. K3 ställer större krav på kunskap vid professionell bedömning då regelverket tar hänsyn till en komplex verksamhet med fler företagsintressenter.Title: K2 or K3 : Reasons to account according to K3 Authors: Adrian Zhubi and Albert Zhubi Published: Spring 2016 Tutor: Eva Berggren Background: Since 2004 BFN has given accounting standards, which started the K-project that divides companies into four different categories based on company size. The K-project's most common regulations are the main regulation principles-based K3 and the alternative regulation rules-based K2. Since 2015 it became mandatory for all joint-stock companies and economic associations to apply one of these two regulations. Companies should therefore reflect on its business and stakeholders when making a choice of regulation. This requires that the annual report should be relevant to the stakeholders. With the study we therefore want to examine the main differences that explains why companies choose K3 instead of K2 from accounting advisors’ perspective. Aim: The aim of the study is to describe why companies prefer K3 instead of K2 according to accounting advisors. Formulation of the problem: What do accounting advisors consider explains the companies’ choice of K3 instead of K2? Methodology: The study is based on a qualitative approach. The empirical data contains a total of five interviews, one of those is a pilot interview. The study's respondents are three auditors, an accounting expert and an accounting specialist. The respondents have different experiences and are from different accounting firms. Results: The study shows that accounting advisors consider differences in tangible, intangible and financial assets between K2 and K3 makes companies prefer K3. Factors as depositions, deferred taxes and stakeholders also affects the choice. According to the study’s respondents, K2 is easier to apply because the regulation contains robust rules for accounting. K3 require greater knowledge at professional judgement, because the regulation includes companies with a complex business with many stakeholders.
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Orsenigo, Christian. "Les tombes KV 34, KV 35, KV 36, KV 37, KV 38 découvertes par Victor Loret dans la Vallée des Rois : « state of the art » à la lumière de nouveaux documents." Paris, EPHE, 2013. http://www.theses.fr/2013EPHE4004.
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La thèse est consacrée à cinq tombes découvertes par Victor Loret lors de ses travaux dans la Vallée des Rois en 1898-1899. Il s’agit de la KV 34 (Thoutmosis III), la KV 35 (Aménophis II), la KV 36 (Maiherperi), la KV 37 (une tombe anonyme) et la KV 38 (Thoutmosis Ier). Le travail s’appuie largement sur la documentation recueillie par Loret pendant ses campagnes de fouilles. Ces notes sont contenues principalement dans des documents conservés à l’Università degli Studi di Milano que les égyptologues avaient considérées longtemps pour perdues, sinon inexistantes. Chaque chapitre comporte le récit de la découverte, la description de la fouille, la méthode utilisée pour la reconstitution de l'équipement funéraire et un catalogue du mobilier parvenu au Musée égyptien du Caire. Ce catalogue se base sur des recherches menées au Musée du Caire, qui ont permis de retrouver pratiquement tous les objets mentionnés par Loret dans ses cahiers, ainsi que d’intégrer ou, souvent de corriger, les données du Journal d'Entrée et du Catalogue Général du Musée. L’étude des notes rédigées par Loret a permis d’indiquer avec précision la constitution d’ensemble du mobilier des tombes traitées et en même temps a permis de mettre fin à plusieurs spéculations sur la disposition des objets au moment de leur découverte. Dans le cas de la KV 35, la « deuxième cachette royale », on a fait le point sur les momies découvertes et tout particulièrement sur l’identification des trois dont le lien de parenté avec Toutânkhamon semble désormais assuréThe dissertation focuses on five tombs discovered by Victor Loret during the excavation campaigns he conducted in the Valley of the Kings in 1898-1899: the KV 34 (Thutmose III), the KV 35 (Amenhotep II), the KV 36 (Maiherperi), the KV 37 (an anonymous tomb) and the KV 38 (Thutmose I). The study is mostly based on the documentation collected by Loret during his excavations in the Valley of the Kings. These papers, mainly belonging to the archives of the Università degli Studi di Milano, have been for a long time considered by Egyptologists lost if not non-existent. Each chapter opens with the account of the discovery and the phases of the excavation, followed by the description of the method adopted for the reconstruction of the funerary equipment. A catalogue of finds that reached the Egyptian Museum in Cairo closes each chapter. This catalogue results from researches conducted at the Museum in Cairo that permitted not only to identify almost all the objects mentioned by Loret in his notes, but also to complete or correct the information entered in the Journal d’Entrée and partially published in the Catalogue Général of the Museum. The study of the notes taken by Loret made possible the clear identification of most of the objects belonging to the funerary equipment as well as their findspot. At the same time it allowed to halt several speculations on the emplacement of the objects at the moment of their discovery. Moreover, some pages are devoted to the mummies discovered in KV 35, the “second royal cache”, especially referring to those whose family relationship with Tutankhamun seems today assured
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Billig, Susan. "Abbau von Polyethylenterephthalat mit PET-Hydrolasen aus Thermobifida fusca KW3." Doctoral thesis, Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-85714.
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Der Actinomycet T. fusca KW3, isoliert aus Kompost, bildete während der Kultivierung im Mineralsalz-Spurenelement-Vitamin-Minimalmedium nach Zusatz von PET-Fasern eine 52 kDa Carboxylesterase (TfCa), welche effizient zyklische PET Trimere (CTR) hydrolysiert. Die TfCa besitzt einen pI von 4,8, eine Substratspezifität gegenüber kurzkettigen p-Nitrophenyl-Estern und wird durch Phenylmethylsulfonylfluorid (PMSF) und Tosyl-L-Phenylalanin-Chloromethylketon (TPCK) in der Aktivität gehemmt. Die Carboxylesterase hydrolysiert kein Cutin oder Poly-ε-caprolacton (PCL). CTR hingegen wurden durch die TfCa mit einem Km von 0,5 mM und einer Vmax von 9,3 μmol/min/mg bei optimalen Bedingungen (60°C, pH 6) hydrolysiert. Das aktive Zentrum der Carboxylesterase besteht aus den Aminosäuren Ser185, Glu319 und His415, wobei das Serin in das katalytische Motiv G-E-S-A-G eingebettet ist.
Während der Reaktion setzte die TfCa auch Hydrolyseprodukte aus PET-Fasern und -Filmen frei. Der Nachweis der Hydrolyse erfolgte durch Umkehrphasen-Hochleistungsflüssigkeitschromatographie der Abbauprodukte und bei den PET-Filmen zusätzlich mittels Rasterelektronenmikroskopie. Dabei zeigte die Carboxylesterase verglichen mit anderen PET-Hydrolasen eine geringere Effizienz, was durch die Lage des aktiven Zentrums in einer Bindungstasche und der daraus folgenden schlechten Zugänglichkeit für polymere Substrate begründet werden kann. Bei der Hydrolyse der viel kleineren CTR war die TfCa deutlich effektiver, was auf eine höhere Spezifität gegenüber kurzkettigen PET Substraten hinweist.
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Reilly, J. M. "Expression of Kv7/M-channels within the peripheral nociceptive pathway." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1388215/.
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Novel targets for the treatment of pain are continually being sought. These new targets may lie within the pain pathway, which facilitates the detection, transmission and perception of pain and include ion channels which control neuronal excitability such as Kv7/M-channels which have been implicated in the control of neuronal excitability in peripheral neurons. The aim of this work was to determine the expression of Kv7/M-channels in the peripheral components of the nociceptive sensory pathway and to investigate aspects of their functional significance. Immunohistochemical techniques to determine the localisation of the channel were completed using antibodies to the Kv7.2 subunit of the channel and to various neuronal makers. Immunoreactivity to Kv7.2 was detected in a variety of DRG sensory neurons and peripheral sensory nerve fibres; including small nociceptive neurons. Immunoreactivity to Kv7.2 was also detected diffusely along unmyelinated fibres within the vagus nerve. Electrophysiological measurement found that these fibres could be hyperpolarised in a XE991 sensitive manner by retigabine. The Kv7/M-channel was also identified in keratinocytes by immunoreactivity for Kv7.2, RT-PCR, electrophysiological recordings and a potentiated induced release of ATP by retigabine was observed, this effect was blocked by XE991. These new neuroanatomical locations for M-channel are helpful in the interpretation of functional studies on the role of M-channels in regulating peripheral nociception. The localisation of the channel in presumably non-nociceptive fibres raises additional possibilities regarding their role in other forms of sensation. The functional studies also expand potential roles for M-channels to the regulation of C-fibre activity and also to aspects of keratinocyte function. These results also raise the question of how far the effects of retigabine (and other M-channel enhancers) observed in other studies are due to peripheral actions.
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Brennan, Sean. "KV7 potassium channels : a focus on human intra-pulmonary arteries." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/kv7-potassium-channels-a-focus-on-human-intrapulmonary-arteries(46f5ff0e-1674-4ab1-916d-2f43e3c585e5).html.
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Pulmonary arterial hypertension (PAH) is a disease in which pulmonary vascular resistance increases. The cell membrane of pulmonary artery smooth muscle cells (PASMC) in PAH patients is depolarised, resulting in disrupted Ca2+ signalling leading to smooth muscle constriction and PASMC proliferation and migration. In rat pulmonary artery (PA) smooth muscle the KV7 K+ channels, encoded by the KCNQ genes, have been proposed to contribute to the resting K+ current, promoting low resting tone by maintaining a negative membrane potential and low intracellular Ca2+. KV7 channel activating drugs have the potential to counteract the dysfunctional signalling during PAH by causing hyperpolarisation. This study set out to determine if the KV7 channels are expressed in human PA and if so whether they can alter vascular tone, PASMC proliferation and/or migration due to their ability to reduce intracellular Ca2+ indirectly. The effects of KV7 K+ channel modulators on human PA tone were measured using myography, while KCNQ gene expression was examined with quantitative PCR. Markers of proliferation (5-bromo-2'-deoxy-uridine (BrdU) and Ki67 antigen), were used to measure PASMC proliferation, while migration was assessed using the scratch-wound assay. Human PASMCs express all KCNQ genes, except KCNQ2. The KV7 channel blockers XE991, linopirdine and (-)chromanol 293B, constricted PAs. The KV7 channel activators retigabine and zinc pyrithione (ZnPy) relaxed PAs pre-constricted with agonists. The retigabine response was enhanced in PAs constricted with Bay K 8644, abolished in ionomycin constricted PAs and reduced in the presence of 90 mM K+, suggesting inhibition of voltage-gated Ca2+ influx. Similar experiments on rat PAs suggest that only part of the ZnPy-induced relaxation can be attributed to KV7 channel activation. The KCNQ5 gene remained in cultured PASMCs while no KV7 channel modulator altered proliferation or migration. Thus KV7.5 channels could possibly be a marker of differentiated PASMCs and/or be involved in the regulation of cell phenotype. The results imply that KV7 channels play a role in regulating PA tone and Ca2+ signalling in PA smooth. It is concluded that although KCNQ5 transcripts are preserved in proliferating PASMC, it is unlikely they play a role in PASMC proliferation or migration. In summary, KV7 channel activators may be useful in the treatment of PAH since they can prevent vasoconstriction.
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Dang, Thi Hue. "Supply of affordable high quality potato seed for potato production in the Red River Delta of Vietnam." Thesis, Curtin University, 2008. http://hdl.handle.net/20.500.11937/2415.
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Poor quality seed is the major constraint limiting both the productivity of potato crops and the expansion of the potato industry in Vietnam. Despite numerous attempts to establish a certified seed system, the most practical solution is to import clean foundation seed of the desired variety and physiological age. With imports from Europe and North America proving to be immature and too expensive, Western Australia (WA) has emerged as a potential source of high quality seed. While seed imports from WA are unique in that the varieties imported have been selected by researchers in Vietnam as being suited to the agro-ecological environment in the Red River Delta (RRD), no assessment of the economic benefits to smallholder potato farmers from the use of WA potato seed has been undertaken. In 2006/08, the yield and profitability of three potato varieties Eben, KT3 and Atlantic in two locations were compared where the crops had been derived from new seed imported from WA (VN0), seed derived from crops cultivated in the RRD after one generation (VN1) and two generations (VN2). There was a significant difference in the yield produced between the three different seed sources but not between the locations. For all varieties, and in both years, the yield decreased with the number of multiplications in Vietnam. Furthermore, the marketable yield declined significantly from the first crop (VN0) to the third crop (VN2). The decline in yield and tuber quality with each successive generation was associated with an increase in PVY and PVX infection. Not unexpectedly, differences in yield and marketable yield between the seed generations had a significant impact on the gross income for each variety.VN0 seed of all varieties produced the highest gross income (VND 2.4 to 4.1 M/sao) compared to VN1 (VND 1.9 to 3.1 M/sao) which was significantly higher than VN2 (VND 1.4 to 2.4 M/sao). However, while high quality seed is more productive, it is also more expensive. As a result, significant differences were observed between the seed costs. VN0 seed was almost two times more expensive (VND 10,500 – 11,000 per kg) than VN1 and VN2 seed (VND 6,000 – 6,500 per kg). Despite the higher costs, VN0 seed provided the highest net incomes compared to VN1 which was significantly higher than VN2. Farmers who retained seed received a higher net income (VND 0.13 – 0.6 M/sao) than those who did not retain seed. Ways to improve the accessibility of affordable, high quality potato seed to farmers in the RRD are discussed.
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Pasumarthy, Sarat Chandra. "Live Migration of Virtual Machines in the Cloud : An Investigation by Measurements." Thesis, Blekinge Tekniska Högskola, Institutionen för kommunikationssystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-10770.
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Cloud computing has grown in prevalence from recent years due to its concept of computing as a service, thereby, allowing users to offload the infrastructure management costs and tasks to a cloud provider. Cloud providers leverage server virtualization technology for efficient resource utilization, faster provisioning times, reduced energy consumption, etc. Cloud computing inherits a key feature of server virtualization which is the live migration of virtual machines (VMs). This technique allows transferring of a VM from one host to another with minimal service interruption. However, live migration is a complex process and with a cloud management software used by cloud providers for management, there could be a significant influence on the migration process. This thesis work aims to investigate the complex process of live migration performed by the hypervisor as well as the additional steps involved when a cloud management software or platform is present and form a timeline of these collection of steps or phases. The work also aims to investigate the performance of these phases, in terms of time, when migrating VMs with different sizes and workloads. For this thesis, the Kernel-based Virtual Machine (KVM) hypervisor and the OpenStack cloud software have been considered. The methodology employed is experimental and quantitative. The essence of this work is investigation by network passive measurements. To elaborate, this thesis work performs migrations on physical test-beds and uses measurements to investigate and evaluate the migration process performed by the KVM hypervisor as well as the OpenStack platform deployed on KVM hypervisors. Experiments are designed and conducted based on the objectives to be met. The results of the work primarily include the timeline of the migration phases of both the KVM hypervisor and the OpenStack platform. Results also include the time taken by each migration phase as well as the total migration time and the VM downtime. The results indicate that the total migration time, downtime and few of the phases increase with increase in CPU load and VM size. However, some of the phases do not portray any such trend. It has also been observed that the transfer stage alone does not contribute and influence the total time but every phase of the process has significant influence on the migration process. The conclusions from this work is that although a cloud management software aids in managing the infrastructure, it has notable impact on the migration process carried out by the hypervisor. Moreover, the migration phases and their proportions not only depend on the VM but on the physical environment as well. This thesis work focuses solely on the time factor of each phase. Further evaluation of each phase with respect to its resource utilization can provide better insight into probable optimization opportunities.
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Harshini, Nekkanti. "Measuring And Modeling Of Open vSwitch Performance : Implementation in Docker." Thesis, Blekinge Tekniska Högskola, Institutionen för kommunikationssystem, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-13479.
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Network virtualization has become an important aspect of the Telecom industry. The need forefficient, scalable and reliable virtualized network functions is paramount to modern networking.Open vSwitch is such virtual switch that attempts to extend the usage of virtual switches to industrygrade performance levels on heterogeneous platforms.The aim of the thesis is to give an insight into the working of Open vSwitch. To evaluate theperformance of Open vSwitch in various virtualization scenarios such as KVM (second companionthesis)[1] and Docker. To investigate different scheduling techniques offered by the Open vSwitchsoftware and supported by the Linux kernel such as FIFO, SFQ, CODEL, FQCODEL, HTB andHFSC. To differentiate the performance of Open vSwitch in these scenarios and scheduling capacitiesand determine the best scenario for optimum performance.The methodology of the thesis involved a physical model of the system used for real-timeexperimentation as well as quantitative analysis. Quantitative analysis of obtained results paved theway for unbiased conclusions. Experimental analysis was required to measure metrics such asthroughput, latency and jitter in order to grade the performance of Open vSwitch in the particularvirtualization scenario.The results of the thesis must be considered in context with a second companion thesis[1]. Both thethesis aim at measuring the performance of Open v-Switch but the virtualization scenarios (Dockerand KVM) which are chosen are different, However, this thesis outline the performance of Open vSwitch and linux bridge in docker scenario. Various scheduling techniques were measured fornetwork performance metrics across both Docker and KVM (second companion thesis) and it wasobserved that Docker performed better in terms of throughput, latency and jitter. In Docker scenarioamongst the scheduling algorithms measured, it has almost same throughput in all schedulingalgorithms and latency shows slight variation and FIFO has least latency, as it is a simplest algorithmand consists of default qdisk. Finally jitter also shows variation on all scheduling algorithms.The conclusion of the thesis is that the virtualization layer on which Open vSwitch operates is one ofthe main factors in determining the switching performance. The KVM scenario and Docker scenarioeach have different virtualization techniques that incur different overheads that in turn lead to differentmeasurements. This difference occurs in different packet scheduling techniques. Docker performsbetter than KVM for both bridges. In the Docker scenario Linux bridge performs better than that ofOpen vSwitch, throughput is almost constant and FIFO has a least latency amongst all schedulingalgorithms and jitter shows more variation in all scheduling algorithms.
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Pothuraju, Rohit. "Measuring and Modeling of Open vSwitch Performance : Implementation in KVM environment." Thesis, Blekinge Tekniska Högskola, Institutionen för kommunikationssystem, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-13519.
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Network virtualization has become an important aspect of the Telecom industry. The need for efficient, scalable and reliable virtualized network functions is paramount to modern networking. Open vSwitch is a virtual switch that attempts to extend the usage of virtual switches to industry grade performance levels on heterogeneous platforms.The aim of the thesis is to give an insight into the working of Open vSwitch. To evaluate the performance of Open vSwitch in various virtualization scenarios such as KVM and Docker (from second companion thesis)[1]. To investigate different scheduling techniques offered by the Open vSwitch software and supported by the Linux kernel such as FIFO, SFQ, CODEL, FQCODEL, HTB and HFSC. To differentiate the performance of Open vSwitch in these scenarios and scheduling capacities and determine the best scenario for optimum performance.The methodology of the thesis involved a physical model of the system used for real-time experimentation as well as quantitative analysis. Quantitative analysis of obtained results paved the way for unbiased conclusions. Experimental analysis was required to measure metrics such as throughput, latency and jitter in order to grade the performance of Open vSwitch in the particular virtualization scenario.The result of this thesis must be considered in context with a second companion thesis[1]. Both the theses aim at measuring and modeling performance of Open vSwitch in NFV. However, the results of this thesis outline the performance of Open vSwitch and Linux bridge in KVM virtualization scenario. Various scheduling techniques were measured for network performance metrics and it was observed that Docker performed better in terms of throughput, latency and jitter. In the KVM scenario, from the throughput test it was observed that all algorithms perform similarly in terms of throughput, for both Open vSwitch and Linux bridges. In the round trip latency tests, it was seen that FIFO has the least round trip latency, CODEL and FQCODEL had the highest latencies. HTB and HFSC perform similarly in the latency test. In the jitter tests, it was seen that HTB and HFSC had highest average jitter measurements in UDP Stream test. CODEL and FQCODEL had the least jitter results for both Open vSwitch and Linux bridges.The conclusion of the thesis is that the virtualization layer on which Open vSwitch operates is one of the main factors in determining the switching performance. Docker performs better than KVM for both bridges. In the KVM scenario, irrespective of the scheduling algorithm considered, Open vSwitch performed better than Linux bridge. HTB had highest throughput and FIFO had least round trip latency. CODEL and FQCODEL are efficient scheduling algorithms with low jitter measurements.
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Kopunec, Kristián. "Technická řešení přepojení hladiny VN z 35 kV na 22 kV." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2020. http://www.nusl.cz/ntk/nusl-413144.
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The diploma thesis deals with the design of the connection of the Svratecko area with the distribution network of the company E.ON Distribuce, a.s.. The theoretical part describes the energy legislation and the individual standards on which the thesis is based. It also describes the concept of a 22 kV high voltage network. The practical part of the thesis is focused on the creation of line models in the program E-vlivy, which will supply the Svratecko area and the model of the monitored area. Outputs from the thesis will be used by E.ON Distribuce, a.s. to evaluate the connection of the Svratecko area.
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Beimgraben, Christian [Verfasser]. "Assemblierung und Pharmakologie von spannungsabhängigen KCNQ (Kv7) K+ Kanälen / Christian Beimgraben." Kiel : Universitätsbibliothek Kiel, 2008. http://d-nb.info/1019670525/34.
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Aereboe, Michael. "A structural study of the capsular antigen of Klebsiella serotype K43." Thesis, Rhodes University, 1993. http://hdl.handle.net/10962/d1003218.
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This thesis presents a detailed chemical and spectroscopic determination of the capsular, polysaccharide K-antigen isolated from the Klebsiella bacterium, serotype K43 (culture #2482). The repeating unit of the capsular polysaccharide was found to be of the "3 + 2" repeating unit type. A uronic acid was found as part of a disaccharide side chain and the main chain of the polysaccharide was found to be composed of a neutral trisaccharide of mannose and galactose. The work forms part of an ongoing research interest in bacterial polysaccharides of this laboratory and now completes the structural elucidation of all the Klebsiella K-antigens, bar three antigens which were originally assigned to other laboratories. These data together with the respective serological characteristics of each serotype are available to the molecular biologist, and may result in the production of: vaccine(s) against Klebsiella infections, diagnostic products and novel carrier molecules enabling targeted drug delivery.
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Flory, Isaac Lynnwood. "Modeling, analysis, and design of a 10 kVA, 20 kHz transformer." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-05042010-020300/.
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Paakkonen, Anna, and Kajsa Ekholm. "K3 - Förenkling eller inte? : En studie av K3:s betydelse för företagen." Thesis, Karlstads universitet, Fakulteten för ekonomi, kommunikation och IT, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-7027.
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Hayakawa, N., A. Ishiyama, N. Amemiya, T. Hasegawa, T. Saitoh, M. Yagi, S. Mukoyama, et al. "Development of 66 kV and 275 kV Class REBCO HTS Power Cables." IEEE, 2013. http://hdl.handle.net/2237/20737.
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Nord, Marcus, and Karam Maqdasi. "Mindre företag och K3 : Vilka anledningar har mindre företag att välja K3?" Thesis, Linköpings universitet, Företagsekonomi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148828.
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Background and problem: It is compulsory for all Swedish companies that prepare the annual report to apply K-regulations. A smaller company can choose between the principle-based K3 and the rule-based K2. There are differences between the accounting and valuation rules in K2 and K3. Some that can only be used in K3 are, for example, component depreciation, capitalization of development costs and accounting for deferred tax. Previous studies found that company size, valuation methods, capitalization opportunities and the industry in which companies operate are reasons for choosing K3. Purpose: The purpose is to find out why smaller companies choose K3, and if there is a relationship between sectors and the choice to apply K3. Method: We used a qualitative method with inductive approach because this study is focused on respondents' views on the reasons for choosing K3. We asked nine accounting consultants for what reasons smaller companies have to choose K3. We also asked three smaller companies for just their reasons to choose K3. We analyzed the empirical findings with institutional theory because it best explains that companies with similar structures mimic each other, and decision theory because it provides an insight into how individuals and organizations decide. Conclusions: We found that business growth, planned or unplanned is a reason for smaller companies to choose K3. The valuation rules that are considered as a reason for choosing K3 are the ability to capitalize development costs, and this opportunity is a clear reason for development companies to choose K3. Component depreciation has been described by many respondents as demanding, and only real estate companies with major renovation needs see advantages of component depreciation. Asset revaluation, deferred tax and external stakeholders are not seen as clear reasons for choosing K3.Bakgrund och problem: Det är obligatoriskt för alla svenska företag som upprättar årsredovisning att tillämpa K-regelverk. Ett mindre företag kan välja mellan det principbaserade regelverket K3 och det regelbaserade K2. Det finns skillnader mellan redovisnings- och värderingsreglerna i K2 och K3. Några som endast kan utnyttjas i K3 är exempelvis komponentindelning, aktivering av utvecklingsutgifter och redovisning av uppskjuten skatt. Tidigare studier fann att bl.a. företagsstorlek, värderingsmetoder, aktiveringsmöjlighet och den bransch som företagen verkar i är anledningar till valet av K3. Syfte: Syftet är att ta reda på varför mindre företag väljer K3, och om det föreligger ett samband mellan branscher och valet att tillämpa K3. Metod: Vi använde oss av en kvalitativ metod med induktiv ansats då denna studie är baserad på respondenternas syn på anledningarna till val av K3. Vi frågade nio redovisningskonsulter om vilka anledningar mindre företag har att välja K3. Vi frågade även tre mindre företag om just deras anledningar att välja K3. Analysen av empirin gjorde vi med dels institutionell teori för att den bäst förklarar att företag med liknande strukturer efterliknar varandra, och dels beslutsteori för att den ger en inblick i hur individer och organisationer beslutar. Slutsatser: Vi kom fram till att företagstillväxt, planerad eller oplanerad är en anledning för mindre företag att välja K3. De värderingsregler som anses vara en anledning att välja K3 är möjligheten att aktivera utvecklingsutgifter, och denna möjlighet är en tydlig anledning för utvecklingsföretag att välja K3. Komponentindelning har av många respondenter beskrivits som krävande, och det är endast fastighetsföretag med renoveringsbehov som ser fördelar med komponentindelning. Uppskrivning av tillgångar, uppskjuten skatt samt externa intressenter kan inte ses som tydliga anledningar till att mindre företag väljer K3.
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Andersson, Lena, and Marie Magnusson. ""Man ska lyssna på fröken!" : - En studie kring barns egna upplevelser av inflytande och delaktighet i förskolan." Thesis, Linnéuniversitetet, Institutionen för utbildningsvetenskap (UV), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-29768.
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Sauntson, Helen Victoria. "Girls, boys and discourse performances : pupil interaction and constructions of gender in the key stage 3 technology classroom." Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364520.
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This thesis explores some ways in which language can be employed as a tool for crosscurricular learning in Key Stage 3 (KS3) education. An examination of how linguistic interaction is employed by pupils as a means of facilitating their attainment of curriculaspecific learning objectives provides a case study for exemplifying how language can be used effectively across disciplines in secondary education. Within the context of exploring pupils' interaction in the subject of Technology, this thesis explores some gender differences in interaction and the potential effects that such differences can have upon gender-differentiated attainment levels in KS3 Technology. The data obtained for the thesis comprises transcripts of small group pupil-pupil discussion taken from KS3 Technology lessons. The conversations of the groups were recorded, transcribed and then analysed using a revised version of Francis and Hunston's (1992) system of discourse analysis. Gender differences in the types of discourse strategies employed by the participants were identified and evaluated in terms of how effectively they function to facilitate the successful attainment of specific learning objectives. The conclusions drawn from the findings of the research are that the discourse collectively produced by the girls in the study tends to be more effective in facilitating the attainment of learning objectives than that which is produced by the boys. This may, in part, provide one possible explanation as to why the girls in the study achieve higher attainment levels in KS3 Technology than the boys.
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Sivalingam, Karthee. "Kaon semileptonic form factor with near physical domain wall quarks." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/8916.
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The CKM matrix element |Vus| can be extracted from the experimental measurement of semileptonic K → π decays and theoretical input for the corresponding vector form factor in QCD. The thesis performs a major improvement of the RBC/UKQCD programme to calculate Kl3 form factor in Nf = 2+1 Lattice QCD using domain wall fermions. We use data from several lattice spacings and dfferent quark masses with lightest pion mass of about 170MeV. Systematic error corresponding to interpolation in the momentum transfer is avoided using partially twisted boundary conditions. Using simulated quark masses near the physical point, reduce the systematic error due to the mass extrapolation. This work explores different kinematic arrangements of pion and Kaon momenta for twisted boundary conditions. This thesis proposes a new ansatz for mass extrapolation. Analysing three sets of simulation data allows for a detailed study of systematic effects leading to the prediction f+kπ (0) = 0:9671(17)(+18-46), where the first error is statistical and the second error systematic. The result allows us to extract the CKM matrix element |Vus| = 0:2237(+13-8) and confirm unitarity of the first row CKM matrix in the Standard Model. Also in this thesis, we discuss porting of Clover Lattice fermion action to Blue Gene-Q architecture. Clover action achieves maximum efficiency of 29.1% for single precision with good weak scaling. Strong scaling shows local volume dependency. In a study of different iterative solvers for Domain Wall Fermion action (DWF), we find that Modified Conjugate Residual(MCR) and Multishift MCR as the most efficient solver compared to CG and GCR. A new probing technique for estimating the diagonal of the inverse Dirac operator in Lattice QCD is introduced and this method is found to be closer to the exact solution than stochastic methods.
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Drescher, Michael Stuart. "A Flattened Hierarchical Scheduler for Real-Time Virtual Machines." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/78125.
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The recent trend of migrating legacy computer systems to a virtualized, cloud-based environment has expanded to real-time systems. Unfortunately, modern hypervisors have no mechanism in place to guarantee the real-time performance of applications running on virtual machines. Past solutions to this problem rely on either spatial or temporal resource partitioning, both of which under-utilize the processing capacity of the host system. Paravirtualized solutions in which the guest communicates its real-time needs have been proposed, but they cannot support legacy operating systems. This thesis demonstrates the shortcomings of resource partitioning using temporally-isolated servers, presents an alternative solution to the scheduling problem called the KairosVM Flattening Scheduling Algorithm, and provides an implementation of the algorithm based on Linux and KVM. The algorithm is analyzed theoretically and an exact schedulability test for the algorithm is derived. Simulations show that the algorithm can schedule more than 90% of all randomly generated tasksets with a utilization less than 0.95. In comparison to the state-of-the-art server based approach, the KairosVM Flattening Scheduling Algorithm is able to schedule more than 20 times more tasksets with utilization of 0.95. Experimental results demonstrate that the Linux-based implementation is able to match the deadline satisfaction ratio of a state-of-the-art server-based approach when the taskset is schedulable using the state-of-the-art approach. When tasksets are unschedulable, the implementation is able to increase the deadline satisfaction ratio of Vanilla KVM by up to 400%. Furthermore, unlike paravirtualized solutions, the implementation supports legacy systems through the use of introspection.Master of Science
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Burns, Kevin Patrick. "Real-Time Hierarchical Scheduling of Virtualized Systems." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/51790.
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In industry there has been a large focus on system integration and server consolidation, even for real-time systems, leading to an interest in virtualization. However, many modern hypervisors do not inherently support the strict timing guarantees of real-time applications. There are several challenges that arise when trying to virtualize a real-time application. One key challenge is to maintain the guest's real-time guarantees. In a typical virtualized environment there is a hierarchy of schedulers. Past solutions solve this issue by strict resource reservation models. These reservations are pessimistic as they accommodate the worst case execution time of each real-time task. We model real-time tasks using probabilistic execution times instead of worst case execution times which are difficult to calculate and are not representative of the actual execution times. In this thesis, we present a probabilistic hierarchical framework to schedule real-time virtual machines. Our framework reduces the number CPUs reserved for each guest by up to 45%, while only decreasing the deadline satisfaction by 2.7%. In addition, we introduce an introspection mechanism capable of gathering real-time characteristics from the guest systems and present them to the host scheduler. Evaluations show that our mechanism incurs up to 21x less overhead than that of bleeding edge introspection techniques when tracing real-time events.Master of Science
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Kou, Tong-Zhang. "Parameter estimation for exponential signals in colored noise using the pseudo-autoregressive (PAR) model." Diss., This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-03042009-041238/.
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Carlström, Dan, Oskar Cederlund, and Christer Pettersson. "K3-regelverket : Förenklade redovisningsregler?" Thesis, Karlstad University, Faculty of Economic Sciences, Communication and IT, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-999.
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Utvecklingen inom redovisningsområdet har gått i mycket rask takt. Den svenska
lagstiftningen har anpassats till EG-rätten och gjort redovisningen onödigt svår och
komplicerad för onoterade svenska företag. På grund av detta har bokföringsnämnden
idag delat upp företag i fyra olika kategorier med olika redovisningskrav beroende på
storlek. Dessa kategorier benämns K1, K2, K3 och K4. Denna kandidatuppsats är
begränsad till att enbart behandla K3.
Bokföringsnämnden har än så länge enbart lagt fram ett utkast för K3-regelverket.
Informationen i utkastet är så pass tunn att syftet med uppsatsen är att försöka ta reda
på hur det nya regelverket bör utformas, så att det gynnar så många företag som
möjligt inom denna kategori. I teorin beskrivs till en början de regler som gäller för
företag idag, i väntan på att det nya regelverket. Teorin avslutas med en övergripande
beskrivning av K3-regelverket men även en härledning från utkastet till
Redovisningsrådets rekommendationer.
Empirin har framställts genom kvalitativ metod där vi via intervjuer med revisorer i
Karlstad diskuterat kring hur det nya K3-regelverket bör se ut och kan tänkas påverka
de företag som hamnar inom K3.
Efter att ha analyserat empirin och teorin kan det konstateras att många företag
hamnar inom K3. En del är tidigare medelstora företag enligt de gamla gränsvärdena
och dessa företag kommer troligtvis att få försvårade regler. De större K3-företagen
kan däremot få förenklade regler då det nya regelverket kommer att innehålla mindre
tilläggsupplysningar än dagens regler.
Vi anser att det är svårt att lösa denna problematik utan att riva den struktur som finns
inom K3. Vår slutsats är att de mindre K3-företagen bör ha mindre krav med
undantagsregler än om man jämför med de större K3-företagen då det i de mindre K3-
företagen inte finns ett speciellt stort externt intresse.
Lately the accounting area has developed very rapidly. The Swedish law have
adjusted to European law, a result of this fact is that Swedish companies, that are not
listed on Swedish stock-market, have got more unnecessary and difficult rules within
the accounting area. Due to this fact a Swedish financial committee called
bokföringsnämnden has divided Swedish companies in four categories. These
categories are, K1, K2, K3 and K4. This paper is limited just to the category 3.
Bokföringsnämnden has so far only presented a short draft of this K3 rules. The
information in this draft is so thin that the purpose with this paper is to determine how
these laws should be designed so that it benefit as many companies as possible in this
category. In the first part of this paper we present the theory of this subject. We start
the theory by explaining how today’s rules is designed, and end it with a overall
description of the K3 rules. We will also try to draw parallels with the draft of the K3
rules, and today’s present rules.
The empirical study is done with qualitative method. This empirical study contains
interviews with accountings in Karlstad. The interviews are based on a discussion of
how this K3 rules should be designed and how this will affect the companies within
this category.
When we analysed the empirical study with the theory we realised that rules of K3
companies will affect a lot the Swedish companies. Some of these companies are
according to the old rules average big companies, and these companies will most
likely be affected negative with harder and more complicated rules. The bigger
companies within category 3, on the other hand, might get easier rules due to the fact
that this new rules will be a little bit easer compared to today’s rules for big Swedish
companies.
We think that this problem will be very hard to solve without destroying the structure
within the K3-rules. One suggestion to solve this problem is that the smallest
companies within category 3 will get less complicated rules and the possibility to use
some lighter rules form category 2. We think that this would work do to the fact that
smaller K3-companies don’t have the same demands from for example external
stockholders.
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Svensson, Staffan. "Urban building kv. domherren." Thesis, KTH, Arkitektur, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-96091.
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Vertical village är ett tätt kvarter på östermalm med sammanlänkande trappor och gator som tar dig upp i stadsrummet, en förlängning av staden upp över takåsarna med vidsträckt utsikt. Längs din väg upp mellan gator och gränder nns liv och rörelse. För att skapa denna o-entlighet krävs en öppen byggnad med god förankring till marknivån men istället för ett traditionellt kvarter med o-entlig verksamhet i markplan valde jag att lyfta det o-entliga rummet över takåsarna med utblick över staden. Detta skulle bli ett o-entligt rum på Östermalm som man söker sig till på samma sätt som observatorielunden eller söders höjder. I mitt projekt har jag valt att arbeta med två skalor, den mindre som blir det o-entliga stadsrummet medan bostäder och kontor ger byggnaden sin höjd. Sett från staden ska byggnaden upplevas som en upphöjd fortsättning av gatan med en mindre skala som på ett spännande sätt bjuder in till detta stadsliv. Det o-entliga rummet blir som en hel servisyta i direkt anknytning till din bostad eller kontor och på så vis skapar ett naturligt liv för de verksamma på platsen men även ett öppet stadsrum som alla kan ta del av. Detta gör denna byggnad till en del av staden samtidigt som byggnaden själv blir en stad i staden. Jag ser på byggnaden som ett omprogrammerat kvarter men mer vertikalt än horisontellt, staden får istället bästa läge med utblick över hela Stockholm genom vertikala gator som klättrar upp i stadsrummet. Byggnaden består av vertikala hus för bostäder och i det mellanrummet som uppstår mellan husen bildas kontorsytor en delad programindelning i symbios med två garageplan och ett underliggande Plaza som ger byggnaden sitt podium. Garaget blir även en urban plats i staden som kan användas till mycket mer än bara parkering, det bildar ett torg i tre plan med en hel pelarskog som blir rumbildande
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Ericson, Arielle, and Lizette Flood. "Energikartläggning för Kv Sälen." Thesis, Högskolan i Gävle, Avdelningen för bygg- energi- och miljöteknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-20053.
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Johansson, Pontus. "Produktionsoptimering av Kv. Hunden." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-87942.
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For many years, there has been a housing shortage in Sweden. Many have been expecting a construction boom in the housing sector, but that has yet to arrive. With the current legislations and guidelines surrounding modern, energy efficient housing; production costs have increased dramatically in recent years. As a result, having a negative effect on housing production despite the high demand for homes. This exam work is carried out on a construction project of Sjötorpshus AB and its purpose is to evaluate how to optimise the construction process for the production of a new residential settlement, "Kv.Hunden", located in Katrineholm. In an interview with the company's MD, Pär Knutsson, four main issues were defined to focus on. The key issues that will be looked at in this project are: the choice of the production model, i.e. the use of raw timber materials vs. prefabricated wooden structures. Utilisation of workers in each stage of production. Optimisation of the more expensive fixtures in the workplace. Determining which parts of the project are vital to aid progression of work. The study was conducted through a literature review of books, articles, reports and case studies l of similar projects undertaken by Sjötorpshus. Relevant theories have come together to form a base in the study. The price calculations attached are made in BidCon, a spreadsheet software, and project plans in planning program PlanCon, also spreadsheet software. The results of the report will indicate that the production of loose timber is the most lucrative for the current project. Work should be carried out in small groups where each work team manages their own part of the production. The study concludes with a discussion where my own recommendations to the company will be highlighted, those recommendations will be made built on the facts developed during the project.I många år har man talat om den bostadsbrist som råder i landet och den byggboom som ständigt förväntas komma, men aldrig gör det. Med dagens alla regler då det gäller energieffektiv byggande så har produktionskostnaden stigit i höjden de senaste åren. Vilket bidrar till att hålla nere produktionen, trots den stora efterfrågan. Detta examensarbete utförs på uppdrag av Sjötorpshus AB och har som syfte att utvärdera hur man kan gå till väga för att effektivisera byggprocessen för produktionen av ett nytt bostadsområde ”Kv. Hunden” beläget i centrala Katrineholm. I ett samtal med företagets VD Pär Knutsson så fastställdes de fyra viktigaste frågorna att belysa. De frågor som behandlas inom detta arbete är: Val av produktionsmodell, lösvirke eller prefabricerade träkonstruktioner. Personalfrågan om hur nyttjandet av varje individ maximeras i alla produktionsleden. Hur nyttjandegraden för de dyrare inventarierna maximeras på arbetsplatsen. Vilka delar av projektet som är direkt avgörande för hur arbetet fortlöper. Studien är utförd genom en litteraturstudie av böcker, artiklar, rapporter och kontroll av liknande projekt utförda av Sjötorpshus, varav relevanta teorier har samlats för att utgöra en bas i studien. De prisberäkningarna som finns bifogade är utförda i kalkylprogrammet BidCon och projektplanerna i planeringsprogrammet PlanCon. Resultatet på rapporten kommer at tyda på att produktion av lösvirke är det mest lukrativa för det aktuella projektet. Arbetet bör utföras i mindre grupper där varje arbetsteam har hand om sina delar av produktionen. Studien avslutas med en diskussion där mina egna rekommendationer till Sjötorpshus kommer att läggas fram, dessa kommer att vara byggda på de fakta som tagits fram under projektets gång.
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Lindström, David. "Infart Kv. Vargen 30." Thesis, Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-74017.
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Detta examensarbete kommer att gestalta en ny infart på ett kommande bostadsområde i centrala Piteå. Bostadsområdet heter Vargen 30 och i det ligger idag behandlingsenheten Strömgården samt öppna parkeringar och garage till närboende. Ombyggnationerna kommer även att påverka äldreboendet Österbo vilket kommer att framgå i rapporten. Gestaltningen gör jag med underlag från fysisk planering på Piteå kommun, där Kenneth Sjödin visar den vision som de har utifrån det förutsättningar som finns. Förutsättningar innebär viss mån av inskränkningar i planeringen, som jag måste ta hänsyn till. Befintliga byggnader, fordonstransporter etc., måste tas i beräkning. Examensarbetet bygger på ett verkligt projekt, från vision till färdiga bygghandlingar där flera olika alternativ har tagits fram, samt motivering till varför det blev just det förslaget som valdes. Projekteringen innebar arbete med underlag från Piteå kommun där jag fick anpassa projektet till Norconsults riktlinjer vad gäller standarder och former. Kontakt hölls kontinuerligt med ansvarig på Piteå kommun som beslutade hur området skulle planläggas. Arbetsgången har utförligt beskrivits i rapportdelen med bilder samt med mina egna tankegångar rörande den nya infarten. Kommunen antog mitt förslag och byggnationerna förväntas starta sommaren 2019.
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Krejčí, Tomáš. "Přeizolace vedení 110 kV." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2015. http://www.nusl.cz/ntk/nusl-221213.
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The master’s thesis deals with the topic new isolation lines of 110 kV. The aim is to propose new insulator hangers. The first, theoretical part focuses on the development of insulators, cutting and possibilities of application. They are the different materials that are used for the production of insulators HV, advantages and disadvantages long rod and cap and pin insulators. There are also described insulator hangers. The theoretical work is to describe thefittings for overhead transmission lines, which are, used to construct a insulator hanger. The last part of the theoretical work is intended distribution towers for overhead lines HV. The practical part deals with the design of new insulator suspensions for specific lines of 110 kV. The results are drawings newly designed hangers and a list of materials (fittings) for individual towers and the total amount of material. The practical part is calculating the differences in the conductor sag using old and new insulators hangers.
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Yilmaz, Nebi, and Burak Vural. "Jämförelseanalys på minst 5 olika installationslösningar på småhus (byggnad ca 120 kvm)." Thesis, KTH, Byggteknik och design, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215423.
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När det gäller val av installation så har man väldigt svårt att välja rätt. Bland annat för att det finns många lösningar att välja emellan samtidigt som man tänker på vilken som passar bäst. Fem nyckelfrågor som har bidragit till denna rapport: Vem är kunden? Vad vill kunden? Hur vill kunden ha det? När vill kunden ha det? Vad vill kunden betala? Utöver dessa frågeställningar kan val av installationslösningen också bero på vart man bor i landet, ifall det ofta är kallt, blåser och regnar mycket. Dessa frågeställningar är ofta vanliga bland nya villaägare, bygga nytt eller köpa gammalt. Rapporten innehåller olika jämförelser på dem installationslösningar som är favoriter bland alla kunder och kommer göra det enklare för villaägaren att välja rätt installation för huset. Flera företag har blivit intervjuade om vad dem tycker är bästa alternativet. Men flera källor har undersökts och kontrollerats för att ge läsaren en god instruktionsbok. Där kunden istället kommer ställa frågorna till leverantören.When it comes to choose of installation solutions, it's often very difficult to choose the right one. Among other things, there are many solutions to choose from while thinking about which one fits best. Five key issues that have contributed to this report is: Who is the customer? What does the customer want? How does the customer want it? When does the customer want it? What does the customer want to pay? In addition to these issues, the choice of installation solution can also depend on where you live in the country, if it is often cold, blowing and raining, these questions could affect the choice. These issues are often common among new homeowners, building new house or buying old home customers. The report contains different comparisons to those installation solutions that are favorites among all customers according to the suppliers and will make it easier for the homeowner to choose the right installation for the house. Several companies have been interviewed about what they think is the best option. However, several sources have been investigated and checked to give the reader a good instruction manual. Where the customer will have the ability to ask the questions to the supplier.
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Adler, Jameson R. Ahart Jennifer L. "AEGIS platforms using KVA analysis to assess Open Architecture in sustaining engineering /." Monterey, Calif. : Naval Postgraduate School, 2007. http://bosun.nps.edu/uhtbin/hyperion-image.exe/07Jun%5FAdler.pdf.
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Thesis (M.S. in Systems Technology (Command, Control and Communications (C3))--Naval Postgraduate School, June 2007.Thesis Advisor(s): Thomas Housel. "June 2007." Includes bibliographical references (p. 79-82). Also available in print.
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Lambeth, Ira D. Clapp Hubert N. "Using Knowledge Value Added (KVA) for evaluating cryptologic it capabilities trial implementation /." Monterey, Calif. : Naval Postgraduate School, 2007. http://bosun.nps.edu/uhtbin/hyperion-image.exe/07Sep%5FLambeth.pdf.
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Thesis (M.S. in Information Warfare Systems Engineering)--Naval Postgraduate School, September 2007.Thesis Advisor(s): Housel, Thomas J. "September 2007." Description based on title screen as viewed on October 19, 2007. Includes bibliographical references (p. 69). Also available in print.