Journal articles on the topic 'KK/Ay Murine Model'
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Ishii, Hideto, Megumi Hiraoka, Akira Tanaka, Kentaro Shimokado, and Masayuki Yoshida. "Recombinant annexin-2 inhibits the progress of diabetic nephropathy in a diabetic mouse model via recovery of hypercoagulability." Thrombosis and Haemostasis 97, no. 01 (2007): 124–28. http://dx.doi.org/10.1160/th06-07-0381.
Full textLee, So-Young, So-Lim Park, Jin-Taek Hwang, Sung-Hun Yi, Young-Do Nam, and Seong-Il Lim. "Antidiabetic Effect ofMorinda citrifolia(Noni) Fermented byCheonggukjangin KK-AyDiabetic Mice." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/163280.
Full textHunt, Heather B., Jared C. Pearl, David R. Diaz, Karen B. King, and Eve Donnelly. "Bone Tissue Collagen Maturity and Mineral Content Increase With Sustained Hyperglycemia in the KK-Ay Murine Model of Type 2 Diabetes." Journal of Bone and Mineral Research 33, no. 5 (February 8, 2018): 921–29. http://dx.doi.org/10.1002/jbmr.3365.
Full textEvans, Mark J., Paige E. Mahaney, Lisa Borges-Marcucci, KehDih Lai, Shuguang Wang, Julie A. Krueger, Stephen J. Gardell, et al. "A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia." American Journal of Physiology-Gastrointestinal and Liver Physiology 296, no. 3 (March 2009): G543—G552. http://dx.doi.org/10.1152/ajpgi.90585.2008.
Full textKon, Kazuyoshi, Kenichi Ikejima, Kyoko Okumura, Kumiko Arai, Tomonori Aoyama, and Sumio Watanabe. "Diabetic KK-Ay mice are highly susceptible to oxidative hepatocellular damage induced by acetaminophen." American Journal of Physiology-Gastrointestinal and Liver Physiology 299, no. 2 (August 2010): G329—G337. http://dx.doi.org/10.1152/ajpgi.00361.2009.
Full textShao, Xi, Yongqing Yang, Zhifen Tan, Yuanjun Ding, Erping Luo, Da Jing, and Jing Cai. "Amelioration of bone fragility by pulsed electromagnetic fields in type 2 diabetic KK-Ay mice involving Wnt/β-catenin signaling." American Journal of Physiology-Endocrinology and Metabolism 320, no. 5 (May 1, 2021): E951—E966. http://dx.doi.org/10.1152/ajpendo.00655.2020.
Full textMizuno, Yu, Takeshi Yamamotoya, Yusuke Nakatsu, Koji Ueda, Yasuka Matsunaga, Masa-Ki Inoue, Hideyuki Sakoda, et al. "Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice." International Journal of Molecular Sciences 20, no. 19 (September 21, 2019): 4680. http://dx.doi.org/10.3390/ijms20194680.
Full textHiramoto, Keiichi, Kenji Goto, Shota Tanaka, Tsuneki Horikawa, and Kazuya Ooi. "Skin, Liver, and Kidney Interactions Contribute to Skin Dryness in Aging KK-Ay/Tajcl Mice." Biomedicines 10, no. 10 (October 20, 2022): 2648. http://dx.doi.org/10.3390/biomedicines10102648.
Full textKitagawa, Ryuta, Kazuyoshi Kon, Akira Uchiyama, Kumiko Arai, Shunhei Yamashina, Kyoko Kuwahara-Arai, Teruo Kirikae, Takashi Ueno, and Kenichi Ikejima. "Rifaximin prevents ethanol-induced liver injury in obese KK-Ay mice through modulation of small intestinal microbiota signature." American Journal of Physiology-Gastrointestinal and Liver Physiology 317, no. 5 (November 1, 2019): G707—G715. http://dx.doi.org/10.1152/ajpgi.00372.2018.
Full textJia, Yanmei, and Lirong Chen. "Antidiabetic Activity of Picris japonica Thunb Aqueous Extract in Diabetic KK-Ay Mice." Evidence-Based Complementary and Alternative Medicine 2018 (November 12, 2018): 1–5. http://dx.doi.org/10.1155/2018/1298030.
Full textYang, Lixia, Jianjun Xue, Xiangyun Meng, Yongsheng Wang, Lili Wu, Cuiyan Lv, Tonghua Liu, and Yu Bai. "Effects of total flavonoids from Oxytropis falcata Bunge on the SOCS/JAK/STAT inflammatory signaling pathway in the kidneys of diabetic nephropathy model mice." European Journal of Inflammation 17 (January 2019): 205873921986187. http://dx.doi.org/10.1177/2058739219861877.
Full textLiu, Liping, Anmei Shu, Yihui Zhu, and Yuping Chen. "Cornuside Alleviates Diabetes Mellitus-Induced Testicular Damage by Modulating the Gut Microbiota." Evidence-Based Complementary and Alternative Medicine 2021 (August 30, 2021): 1–13. http://dx.doi.org/10.1155/2021/5301942.
Full textOmote, Keisuke, Tomohito Gohda, Maki Murakoshi, Yu Sasaki, Saiko Kazuno, Tsutomu Fujimura, Masanori Ishizaka, Yuji Sonoda, and Yasuhiko Tomino. "Role of the TNF pathway in the progression of diabetic nephropathy in KK-Ay mice." American Journal of Physiology-Renal Physiology 306, no. 11 (June 1, 2014): F1335—F1347. http://dx.doi.org/10.1152/ajprenal.00509.2013.
Full textShi, Si, Hua‐Jing Yin, Jiang Li, Ling Wang, Wei‐Ping Wang, and Xiao‐Liang Wang. "Studies of pathology and pharmacology of diabetic encephalopathy with KK‐Ay mouse model." CNS Neuroscience & Therapeutics 26, no. 3 (August 11, 2019): 332–42. http://dx.doi.org/10.1111/cns.13201.
Full textArai, Kiyoshi, Yuka Morikawa, Naoko Ubukata, and Kotaro Sugimoto. "Synergistic reduction in albuminuria in type 2 diabetic mice by esaxerenone (CS-3150), a novel nonsteroidal selective mineralocorticoid receptor blocker, combined with an angiotensin II receptor blocker." Hypertension Research 43, no. 11 (July 2, 2020): 1204–13. http://dx.doi.org/10.1038/s41440-020-0495-0.
Full textKondo, Shinji, Shin-ichi Adachi, Fumiaki Yoshizawa, and Kazumi Yagasaki. "Antidiabetic Effect of Taxifolin in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Hyperglycemia and Hyperuricemia." Current Issues in Molecular Biology 43, no. 3 (September 26, 2021): 1293–306. http://dx.doi.org/10.3390/cimb43030092.
Full textSørensen, Lasse E., Per B. Jeppesen, Christine B. Christiansen, Kjeld Hermansen, and Søren Gregersen. "Nordic Seaweed and Diabetes Prevention: Exploratory Studies in KK-Ay Mice." Nutrients 11, no. 6 (June 25, 2019): 1435. http://dx.doi.org/10.3390/nu11061435.
Full textHorie, Kayo, Hayato Maeda, Naoki Nanashima, and Indrawati Oey. "Potential Vasculoprotective Effects of Blackcurrant (Ribes nigrum) Extract in Diabetic KK-Ay Mice." Molecules 26, no. 21 (October 26, 2021): 6459. http://dx.doi.org/10.3390/molecules26216459.
Full textRavi Kumar, Sangeetha, Ippei Yamauchi, Bhaskar Narayan, Ami Katsuki, Masashi Hosokawa, and Kazuo Miyashita. "Squalene modulates fatty acid metabolism: Enhanced EPA/DHA in obese/diabetic mice (KK-Ay) model." European Journal of Lipid Science and Technology 118, no. 12 (May 17, 2016): 1935–41. http://dx.doi.org/10.1002/ejlt.201600006.
Full textYABUKI, Akira, Kazuyuki TANIGUCHI, and Osamu YAMATO. "Immunohistochemical Examination of Cyclooxygenase-2 and Renin in a KK-Ay Mouse Model of Diabetic Nephropathy." Experimental Animals 59, no. 4 (2010): 479–86. http://dx.doi.org/10.1538/expanim.59.479.
Full textOtabe, S., N. Wada, T. Hashinaga, X. Yuan, I. Shimokawa, T. Fukutani, K. Tanaka, et al. "Hyperadiponectinemia protects against premature death in metabolic syndrome model mice by inhibiting AKT signaling and chronic inflammation." Journal of Endocrinology 213, no. 1 (January 26, 2012): 67–76. http://dx.doi.org/10.1530/joe-11-0329.
Full textZhao, Shao-Yang, Huan-Huan Zhao, Ting-Ting Hao, Wei-Wei Li, and Hao Guo. "Effect of Bushen Huoxue Prescription on Cognitive Dysfunction of KK-Ay Type 2 Diabetic Mice." Evidence-Based Complementary and Alternative Medicine 2021 (March 12, 2021): 1–14. http://dx.doi.org/10.1155/2021/6656362.
Full textViswanadham, K. K. DurgaRao, Roland Böttger, Lukas Hohenwarter, Anne Nguyen, Elham Rouhollahi, Alexander Smith, Yi-Hsuan Tsai, et al. "An Effective and Safe Enkephalin Analog for Antinociception." Pharmaceutics 13, no. 7 (June 22, 2021): 927. http://dx.doi.org/10.3390/pharmaceutics13070927.
Full textSekijima, Hidehisa, Kenji Goto, Keiichi Hiramoto, Rio Komori, and Kazuya Ooi. "Characterization of dry skin associating with type 2 diabetes mellitus using a KK-Ay/TaJcl mouse model." Cutaneous and Ocular Toxicology 37, no. 4 (July 31, 2018): 391–95. http://dx.doi.org/10.1080/15569527.2018.1490746.
Full textITO, TAKAMICHI, MITSUO TANIMOTO, KAORI YAMADA, SHIGERU KANEKO, MASAKAZU MATSUMOTO, KEIKO OBAYASHI, SHINJI HAGIWARA, et al. "Glomerular changes in the KK-Ay/Ta mouse: A possible model for human type 2 diabetic nephropathy." Nephrology 11, no. 1 (February 2006): 29–35. http://dx.doi.org/10.1111/j.1440-1797.2006.00543.x.
Full textIshikawa, Yuji, Takamichi Ito, Mitsuo Tanimoto, Shinji Hagiwara, Masako Furukawa, Saori Yamaguchi, Keisuke Omote, et al. "Podocyte loss and albuminuria of KK-Ay mouse: A spontaneous animal model for human type 2 diabetic nephropathy." Journal of Diabetes Mellitus 02, no. 03 (2012): 346–52. http://dx.doi.org/10.4236/jdm.2012.23054.
Full textChakraborty, Goutam, Sherin Thumpayil, David-Erick Lafontant, Wolde Woubneh, and Jeffrey H. Toney. "Age dependence of glucose tolerance in adult KK-Ay mice, a model of non–insulin dependent diabetes mellitus." Lab Animal 38, no. 11 (November 2009): 364–68. http://dx.doi.org/10.1038/laban1109-364.
Full textZha, Jun, Xiao-wei Chi, Xiao-lin Yu, Xiang-meng Liu, Dong-qun Liu, Jie Zhu, Hui Ji, and Rui-tian Liu. "Interleukin-1β-Targeted Vaccine Improves Glucose Control and β-Cell Function in a Diabetic KK-Ay Mouse Model." PLOS ONE 11, no. 5 (May 6, 2016): e0154298. http://dx.doi.org/10.1371/journal.pone.0154298.
Full textTomino, Yasuhiko. "Lessons From the KK-Ay Mouse, a Spontaneous Animal Model for the Treatment of human Type 2 Diabetic Nephropathy." Nephro-Urology Monthly 4, no. 3 (June 20, 2012): 524–29. http://dx.doi.org/10.5812/numonthly.1954.
Full textKamakura, Remi, Myoung Jin Son, Dalene de Beer, Elizabeth Joubert, Yutaka Miura, and Kazumi Yagasaki. "Antidiabetic effect of green rooibos (Aspalathus linearis) extract in cultured cells and type 2 diabetic model KK-Ay mice." Cytotechnology 67, no. 4 (November 20, 2014): 699–710. http://dx.doi.org/10.1007/s10616-014-9816-y.
Full textChen, Zhong-Hua, Jie Li, Jie Liu, Yuan Zhao, Pu Zhang, Meng-Xue Zhang, and Liu Zhang. "Saponins Isolated from the Root of Panax notoginseng Showed Significant Anti-Diabetic Effects in KK-Ay Mice." American Journal of Chinese Medicine 36, no. 05 (January 2008): 939–51. http://dx.doi.org/10.1142/s0192415x08006363.
Full textMIURA, Toshihiro, Yasushi ITOH, and Torao ISHIDA. "Impairment of Insulin-induced GLUT4 Translocation in Skeletal Muscle of KK-Ay Mouse, a Genetic Animal Model of Type 2 Diabetes." Biomedical Research 23, no. 5 (2002): 209–12. http://dx.doi.org/10.2220/biomedres.23.209.
Full textKang, Inhae, Seojin Choi, Tae Joung Ha, Munji Choi, Hae-Ri Wi, Byong Won Lee, and Myoungsook Lee. "Effects of Mung Bean (Vigna radiata L.) Ethanol Extracts Decrease Proinflammatory Cytokine-Induced Lipogenesis in the KK-Ay Diabese Mouse Model." Journal of Medicinal Food 18, no. 8 (August 2015): 841–49. http://dx.doi.org/10.1089/jmf.2014.3364.
Full textKato, H., M. Ohue, K. Kato, A. Nomura, K. Toyosawa, Y. Furutani, S. Kimura, and T. Kadowaki. "Mechanism of Amelioration of Insulin Resistance by 3-Adrenoceptor Agonist AJ-9677 in the KK-Ay/Ta Diabetic Obese Mouse Model." Diabetes 50, no. 1 (January 1, 2001): 113–22. http://dx.doi.org/10.2337/diabetes.50.1.113.
Full textMuto, Y., J. Satoh, G. Muto, T. Masuda, M. Sagara, M. Fukuzawa, S. Miyaguchi, et al. "Effect of Long-Term Treatment with Complete Freund's Adjuvant on KK-Ay Mouse, a Model of Non-Insulin-Dependent Diabetes Mellitus." Clinical Immunology and Immunopathology 83, no. 1 (April 1997): 53–59. http://dx.doi.org/10.1006/clin.1997.4328.
Full textUeda-Wakagi, Manabu, Hironobu Nagayasu, Yoko Yamashita, and Hitoshi Ashida. "Green Tea Ameliorates Hyperglycemia by Promoting the Translocation of Glucose Transporter 4 in the Skeletal Muscle of Diabetic Rodents." International Journal of Molecular Sciences 20, no. 10 (May 16, 2019): 2436. http://dx.doi.org/10.3390/ijms20102436.
Full textMATSUZAKI, TAKESHI, RYUTA YAMAZAKI, SHUSUKE HASHIMOTO, and TERUO YOKOKURA. "Antidiabetic Effects of an Oral Administration of Lactobacillus casei in a Non-Insulin-Dependent Diabetes Mellitus (NIDDM) Model using KK-Ay Mice." Endocrine Journal 44, no. 3 (1997): 357–65. http://dx.doi.org/10.1507/endocrj.44.357.
Full textMatsuzaki, Takeshi, Ryuta Yamazaki, Shusuke Hashimoto, and Teruo Yokokura. "Antidiabetic effects of an oral administration of Lactobacillus casei in a non-insulin-dependent diabetes mellitus (NIDDM) model using KK-Ay mice." Japanese Journal of Pharmacology 73 (1997): 145. http://dx.doi.org/10.1016/s0021-5198(19)45083-x.
Full textSUDO, Takako, Aiko ISHII, Jun ASAMI, Yoshikatsu UEMATSU, Masako SAITOH, Atsushi NAKAMURA, Norihiro TADA, Tatsuya OHNUKI, Toshi KOMURASAKI, and Junichi NAKAGAWA. "Transgenic Mice Over-expressing Dicarbonyl/L-xylulose Reductase Gene Crossed with KK-Ay Diabetic Model Mice: An Animal Model for the Metabolism of Renal Carbonyl Compounds." Experimental Animals 54, no. 5 (2005): 385–94. http://dx.doi.org/10.1538/expanim.54.385.
Full textGuo, Beining, Kamilia Abdelraouf, Kimberly R. Ledesma, Kai-Tai Chang, Michael Nikolaou, and Vincent H. Tam. "Quantitative Impact of Neutrophils on Bacterial Clearance in a Murine Pneumonia Model." Antimicrobial Agents and Chemotherapy 55, no. 10 (August 1, 2011): 4601–5. http://dx.doi.org/10.1128/aac.00508-11.
Full textTakahashi, Eri, Akinori Okumura, Hiroyuki Unoki-Kubota, Hisashi Hirano, Masato Kasuga, and Yasushi Kaburagi. "Differential proteome analysis of serum proteins associated with the development of type 2 diabetes mellitus in the KK-Ay mouse model using the iTRAQ technique." Journal of Proteomics 84 (June 2013): 40–51. http://dx.doi.org/10.1016/j.jprot.2013.03.014.
Full textGreen, W. R., and J. D. Phillips. "Differential induction of H-2K vs H-2D class I major histocompatibility complex antigen expression by murine recombinant interferon-gamma." Journal of Immunology 137, no. 3 (August 1, 1986): 814–18. http://dx.doi.org/10.4049/jimmunol.137.3.814.
Full textTakagi, Satoshi, Takenori Yamashita, and Toshihiro Miura. "Does a Treadmill Running Exercise Contribute to Preventing Deterioration of Bone Mineral Density and Bone Quality of the Femur in KK-Ay Mice, a Type 2 Diabetic Animal Model?" Calcified Tissue International 101, no. 6 (August 4, 2017): 631–40. http://dx.doi.org/10.1007/s00223-017-0310-3.
Full textSugizaki, Taichi, Mitsuhiro Watanabe, Yasushi Horai, Nao Kaneko-Iwasaki, Eri Arita, Teruo Miyazaki, Kohkichi Morimoto, Akira Honda, Junichiro Irie, and Hiroshi Itoh. "The Niemann-Pick C1 Like 1 (NPC1L1) Inhibitor Ezetimibe Improves Metabolic Disease Via Decreased Liver X Receptor (LXR) Activity in Liver of Obese Male Mice." Endocrinology 155, no. 8 (August 1, 2014): 2810–19. http://dx.doi.org/10.1210/en.2013-2143.
Full textKubota, Sho, Kenji Tokunaga, Tomohiro Umezu, Takako Yokomizo, Motohiko Oshima, Eisaku Iwanaga, Norio Asou, et al. "Lineage-Specific RUNX2 Super-Enhancer Activates MYC Via Translocation (6;8) to Promote the Development of Blastic Plasmacytoid Dendritic Cell Neoplasm." Blood 132, Supplement 1 (November 29, 2018): 761. http://dx.doi.org/10.1182/blood-2018-99-110333.
Full textTrevaskis, James, Ken Walder, Victoria Foletta, Lyndal Kerr-Bayles, Janine McMillan, Adrian Cooper, Scott Lee, et al. "Src Homology 3-Domain Growth Factor Receptor-Bound 2-Like (Endophilin) Interacting Protein 1, a Novel Neuronal Protein that Regulates Energy Balance." Endocrinology 146, no. 9 (September 1, 2005): 3757–64. http://dx.doi.org/10.1210/en.2005-0282.
Full textXu, Chunyang, Biyu Hou, Ping He, Peng Ma, Xinyu Yang, Xiuying Yang, Li Zhang, Guifen Qiang, Wenlan Li, and Guanhua Du. "Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2." Oxidative Medicine and Cellular Longevity 2020 (February 27, 2020): 1–22. http://dx.doi.org/10.1155/2020/6431459.
Full textLiu, Liping, Yuping Chen, Qin Wu, Anmei Shu, and Jihu Sun. "Sodium Butyrate Attenuated Diabetes-Induced Intestinal Inflammation by Modulating Gut Microbiota." Evidence-Based Complementary and Alternative Medicine 2022 (August 22, 2022): 1–12. http://dx.doi.org/10.1155/2022/4646245.
Full textGarland, John M., and Claudius Rudin. "Cytochrome c Induces Caspase-Dependent Apoptosis in Intact Hematopoietic Cells and Overrides Apoptosis Suppression Mediated by bcl-2, Growth Factor Signaling, MAP-Kinase-Kinase, and Malignant Change." Blood 92, no. 4 (August 15, 1998): 1235–46. http://dx.doi.org/10.1182/blood.v92.4.1235.
Full textGarland, John M., and Claudius Rudin. "Cytochrome c Induces Caspase-Dependent Apoptosis in Intact Hematopoietic Cells and Overrides Apoptosis Suppression Mediated by bcl-2, Growth Factor Signaling, MAP-Kinase-Kinase, and Malignant Change." Blood 92, no. 4 (August 15, 1998): 1235–46. http://dx.doi.org/10.1182/blood.v92.4.1235.416k18_1235_1246.
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