Relevant bibliographies by topics / Kidneys – Diseases

Academic literature on the topic 'Kidneys – Diseases'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 August 2024

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Journal articles on the topic "Kidneys – Diseases"

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Moiseev, Sergey V., and Eugene M. Shilov. "Kidney involvement in rare hereditary diseases." Terapevticheskii arkhiv 96, no. 6 (July 7, 2024): 559–64. http://dx.doi.org/10.26442/00403660.2024.06.202722.

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Various rare inherited disorders can be associated with kidney involvement, including glomerulopathies, tubulopathies, multiple cysts, congenital anomalies of the kidneys and urinary tract, urolithiasis, malignant and benign tumors. Genetic nephropathy should be always considered in children, adolescents and young patients with the kidneys or urinary tract disorders and/or patients with positive family anamnesis. Extrarenal manifestations can be a valuable clue for diagnosis of certain hereditary diseases, e.g. neurosensory deafness in Alport syndrome or photofobia in nephropathic cystinosis. Diagnosis of monogenic inherited diseases should be verified by genetic testing. Specific drugs are available for treatment of certain hereditary diseases involving kidney, e.g. Fabry disease, cystinosis, primary hyperoxaluria I type and atypical hemolytic uremic syndrome.
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V. M. Monastyrsʹkyy. "CHARACTERISTICS OF THE KIDNEY PARAMETERS ACCORDING TO THE DATA OF MAGNETIC RESONANCE IMAGING OF PATIENTS WITH UROLITHIASIS IN PERSONS WITH A SINGLE KIDNEY." Clinical anatomy and operative surgery 17, no. 3 (August 28, 2018): 38–43. http://dx.doi.org/10.24061/1727-0847.17.3.2018.6.

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Urolithiasis is one of the most common diseases of the kidneys and urinary tract. The purpose of the study is to compare the size of a single kidney in patients with urolithiasis with parameters of the kidneys of patients with two kidneys who don’t have any diseases of the kidneys and urinary tract. A comprehensive examination of 84 patients with urolithiasis and single kidney and 65 patients with two kidneys who didn’t have any kidney and urinary tract diseases were conducted. The research was carried out on a magnetic resonance tomography Philips Intera-1,5T (standard magnetic resonance protocol included scanning in sagittal, frontal and axial projections to obtain T1 images). The length of the right single kidney is statistically significantly greater (1.18 times) in men with urolithiasis than in men with two kidneys who did not have any kidney and urinary tract disorders (p<0.05). The width, thickness and volume of the kidneys were also statistically significantly larger respectively 1.25 times, 1.27 times and 2.01 times (p <0.05). The parameters of the kidney (length, width, thickness and volume) were larger, respectively, in 1.21 times, 1.26 times, 1.26 times and 1.93 times in women with the single right kidney with urolithiasis. Conclusion. The morphometric parameters of a single kidney in patients with urolithiasis (length, width, thickness and volume) were statistically significantly different from those in patients with two kidneys who don’t have any kidney and urinary tract disorders. The measure of the volume of the right single kidney in men suffering from urolithiasis was the highest (p <0.05) in comparison with the same parameters in patients with two kidneys who don’t have any kidney and urinary tract disorders.
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Dorofeiev, A. E., N. N. Rudenko, I. A. Derkach, and Yu V. Chechula. "Bowel Diseases and Kidneys." GASTROENTEROLOGY, no. 3.57 (September 16, 2015): 101–5. http://dx.doi.org/10.22141/2308-2097.3.57.2015.81532.

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Rantanen, Norman W. "Diseases of the Kidneys." Veterinary Clinics of North America: Equine Practice 2, no. 1 (April 1986): 89–103. http://dx.doi.org/10.1016/s0749-0739(17)30734-4.

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Zakrocka, Izabela, and Wojciech Załuska. "Kynurenine pathway in kidney diseases." Pharmacological Reports 74, no. 1 (October 6, 2021): 27–39. http://dx.doi.org/10.1007/s43440-021-00329-w.

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AbstractKidney diseases have become one of the most common health care problems. Due to a growing number of advanced aged patients with concomitant disorders the prevalence of these diseases will increase over the coming decades. Despite available laboratory tests, accurate and rapid diagnosis of renal dysfunction has yet to be realized, and prognosis is uncertain. Moreover, data on diagnostic and prognostic markers in kidney diseases are lacking. The kynurenine (KYN) pathway is one of the routes of tryptophan (Trp) degradation, with biologically active substances presenting ambiguous properties. The KYN pathway is known to be highly dependent on immunological system activity. As the kidneys are one of the main organs involved in the formation, degradation and excretion of Trp end products, pathologies involving the kidneys result in KYN pathway activity disturbances. This review aims to summarize changes in the KYN pathway observed in the most common kidney disease, chronic kidney disease (CKD), with a special focus on diabetic kidney disease, acute kidney injury (AKI), glomerulonephritis and kidney graft function monitoring. Additionally, the importance of KYN pathway activity in kidney cancer pathogenesis is discussed, as are available pharmacological agents affecting KYN pathway activity in the kidney. Despite limited clinical data, the KYN pathway appears to be a promising target in the diagnosis and prognosis of kidney diseases. Modulation of KYN pathway activity by pharmacological agents should be considered in the treatment of kidney diseases.
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Zhang, Wei, Xiangjun Zhou, Hao Zhang, Qisheng Yao, Yutao Liu, and Zheng Dong. "Extracellular vesicles in diagnosis and therapy of kidney diseases." American Journal of Physiology-Renal Physiology 311, no. 5 (November 1, 2016): F844—F851. http://dx.doi.org/10.1152/ajprenal.00429.2016.

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Extracellular vesicles (EV) are endogenously produced, membrane-bound vesicles that contain various molecules. Depending on their size and origins, EVs are classified into apoptotic bodies, microvesicles, and exosomes. A fundamental function of EVs is to mediate intercellular communication. In kidneys, recent research has begun to suggest a role of EVs, especially exosomes, in cell-cell communication by transferring proteins, mRNAs, and microRNAs to recipient cells as nanovectors. EVs may mediate the cross talk between various cell types within kidneys for the maintenance of tissue homeostasis. They may also mediate the cross talk between kidneys and other organs under physiological and pathological conditions. EVs have been implicated in the pathogenesis of both acute kidney injury and chronic kidney diseases, including renal fibrosis, end-stage renal disease, glomerular diseases, and diabetic nephropathy. The release of EVs with specific molecular contents into urine and plasma may be useful biomarkers for kidney disease. In addition, EVs produced by cultured cells may have therapeutic effects for these diseases. However, the role of EVs in kidney diseases is largely unclear, and the mechanism underlying EV production and secretion remains elusive. In this review, we introduce the basics of EVs and then analyze the present information about the involvement, diagnostic value, and therapeutic potential of EVs in major kidney diseases.
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Malki Mohamed Amine, Ouaddane Alami R, Cheikh Saad bouh khataraty, Ahsaini M, Mellas S, Ammari JE, Tazi MF, El Fassi MJ, and Farih MH. "Ectopic kidney: Associated diseases and treatment." World Journal of Advanced Research and Reviews 21, no. 2 (February 28, 2024): 967–78. http://dx.doi.org/10.30574/wjarr.2024.21.2.2464.

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Ectopic kidney (or “renal ectopia”) describes a kidney that isn’t located in its usual position. The pelvic kidney is a rare congenital urinary malformation. However, it is the most common type of “ectopic” kidneys. It results from a lack of migration of the metanephros which remains in the pelvic position. It is often smaller than a kidney in the lumbar position, but functional. It can be associated with other malformations (urological, vascular, etc.), or present complications such as urolithiasis, hydronephrosis, urinary infection or even tumor. In that case , Urolithiasis is the most common pathology of the pelvic kidney, it can be a source of serious complications. Its discovery requires an etiological investigation in search of a hereditary, metabolic or even infectious disease. In practice, renal pelvic ectopia poses various diagnostic problems; the close relationships of ectopic kidneys with neighboring organs explain the borrowed semiology and diagnostic errors. Alongside medical care, urological care is essential. The choice of treatment in pelvic kidney pathology depends on the pathology in question, its clinical and biological repercussions, as well as the patient's condition and its comorbidities. The use of open surgery and/or laparoscopy in cases of lithiasis pelvic kidney must remain exceptional after having eliminated all possibilities of LEC and endourology surgery.
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Cojocaru, Manole, Inimioara Cojocaru, Isabela Silosi, and Camelia Vrabie. "Kidney Damage in Autoimmune Diseases." Journal of Medical Biochemistry 29, no. 2 (April 1, 2010): 61–65. http://dx.doi.org/10.2478/v10011-010-0007-x.

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Kidney Damage in Autoimmune DiseasesRenal involvement in autoimmunity has many facets. Glomerular, tubular and vascular structures are targeted and damaged as a consequence of autoimmune processes. Immunologically mediated kidney diseases represent the third most common cause of end-stage renal failure (after diabetic and hypertensive nephropathies). Appropriate evalution of patients with immune-mediated kidney diseases requires a meticulous history and physical examination, with particular attention to the urinalysis, tests of renal function and often renal biopsy. The thorough clinician should personally review microscopic urinalysis in any case in which there is a reasonable index of suspicion of immune-mediated renal disease. In this article we propose to highlight recent developments, with particular reference to renal autoimmunity. Systemic lupus erythe-matosus affects many parts of the body: primarily the skin and joints, but also the kidneys. Goodpasture's syndrome involves an autoantibody that specifically targets the kidneys and the lungs. IgA nephropathy is a form of glomerular disease that results when immunoglobulin A (IgA) forms deposits in the glomeruli, where it creates inflammation. Future research could look for how the disease occurs, and how to easily test for its presence so that early treatment could be started.
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Kutsenko, Lyudmila V., Albina A. Vyalkova, and Igor V. Zorin. "Features of kidney damage in endocrine diseases in children." Russian Pediatric Journal 24, no. 3 (July 16, 2021): 187–92. http://dx.doi.org/10.46563/1560-9561-2021-24-3-187-192.

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The purpose of the work is to determine the clinical and pathogenetic markers of secondary kidney damage in endocrine diseases in children to optimize the diagnosis of secondary nephropathies. Materials and methods. We examined 120 children with endocrinopathies aged 3 to 17 years: with secondary kidney damage in type 1 diabetes mellitus (25), exogenous constitutional obesity (20), autoimmune thyroiditis (15) and 60 children with endocrine diseases without kidney damage. All children underwent a clinical and paraclinical examination with an assessment of the endocrine and nephrological status: determination of the parameters of the lipid spectrum, glycemic profile, indicators of daily monitoring of blood pressure and the functional state of the kidneys. Results. Structural and functional parameters of the kidneys in patients with secondary nephropathies in endocrine diseases are characterized by: impaired echographic parameters of the kidneys and a decrease in intrarenal hemodynamics; increased blood pressure and hyperfiltration increased albuminuria/proteinuria in combination with dyslipidemia (increased low-density lipoprotein cholesterol, triacylglycerides, decreased high-density lipoprotein cholesterol), impaired carbohydrate metabolism (increased glycated haemoglobin levels, impaired glucose tolerance). Conclusion. The optimization of the diagnosis of secondary nephropathies in endocrine diseases in children is discussed based on the determination of a complex of clinical and pathogenetic factors that affect the formation of kidney pathology in children with endocrine diseases.
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Krasiuk, I. V., L. D. Denova, and O. V. Karpenko. "Modern paradigm in the diagnosis of cystic diseases of the kidneys." KIDNEYS 13, no. 1 (March 14, 2024): 72–79. http://dx.doi.org/10.22141/2307-1257.13.1.2024.444.

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Cystic diseases of the kidneys are a fairly common pathology, which has a negative impact on the course of underlying disease affecting the kidneys, or even being the primary renal pathology. The purpose of this review is to analyze the latest literature data on the etiology, pathogenesis, and diagnosis of cystic kidney diseases. This article highlights some aspects of the pathogenesis, diagnosis, and treatment of cystic kidney diseases in order to deepen knowledge about this pathology. Important nuances of ultrasound diagnosis of cystic kidney diseases are discussed. Modern equipment allows diagnosing almost all variants of cystic kidney disease. Training in ultrasound examination or at least knowledge of sonographic interpretation should be part of training in nephro­logy.
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Dissertations / Theses on the topic "Kidneys – Diseases"

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White, Sarah L. "The epidemiology of lifestyle-related and social risk factors for chronic kidney disease, and approaches to the burden of disease." Thesis, The University of Sydney, 2009. https://hdl.handle.net/2123/28217.

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Background and objectives Chronic kidney disease (CKD) refers to a progressive and irreversible loss of kidney function, the key outcomes of which are end-stage kidney disease (ESKD), requiring dialysis or a kidney transplant, or premature death typically due to cardiovascular complications. CKD is identified either by evidence of kidney damage (especially proteinuria or albuminuria) or decreased kidney function, measured according to glomerular filtration rate (GFR). Prevention of CKD, and timely intervention where disease does occur, is an emerging public health priority. However, our understanding of the epidemiology of CKD is still limited, and the evidence base concerning potentially modifiable lifestyle-related risk factors is often deficient or contradictory. Awareness of CKD in the community is low, and informed public health approaches to the burden of disease rare. This thesis is presented as a collection of published works which explore the epidemiology of lifestyle-related and social risk factors for CKD in the general population, and consider potential strategic approaches to the burden of CKD in Australia and internationally. The majority of the analyses presented are based on data derived from the Australian Diabetes, Obesity and Lifestyle (AusDiab) study, a prospective national survey of diabetes, cardiovascular and kidney disease in Australians aged 25 years or older which completed 5-year follow—up in 2005.
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Tang, Chi-wai Sydney, and 鄧智偉. "The many facets of the renal proximal tubular epithelial cell inhuman." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31992468.

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RYLANDER, LESLIE ANN. "PROXIMAL TUBULE SUSPENSIONS FROM RABBIT KIDNEY: AN IN VITRO SYSTEM FOR THE STUDY OF NEPHROTOXICITY." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183785.

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The proximal tubule of the renal cortical nephron is highly susceptible to intoxication by chemical agents. An in vitro system was developed to study directly the effects of nephrotoxic chemicals on this renal sub-organ fraction without the complication of extrarenal factors. Segments of proximal tubules were isolated by a mechanical method from the kidneys of young rabbits. Tubules obtained by this method retained biochemical, functional, and morphological features comparable to those existing in vivo. Preliminary acute susceptibility studies demonstrated that the isolated proximal tubule segments were sensitive to a variety of known nephrotoxic agents that target the proximal tubule. These agents include halogenated hydrocarbons, heavy metals, and a halogenated vinyl cysteine conjugate. Incubation conditions were optimized to maintain the viability of proximal tubule suspensions for up to four hours. Longer incubation times made it possible to establish a chronology of early tubule responses to chemical intoxication. Long term incubation of proximal tubule suspensions with two model nephrotoxins, cadmium chloride and S-(trans-1,2-dichlorovinyl)-L-cysteine, produced in vitro tubule response patterns similar to those reported in vivo for these agents. While not entirely representative of in vivo exposure conditions, suspensions of isolated proximal tubules are an easily obtained system that proved equally applicable as a screening technique for nephrotoxic compounds or as an in vitro system for delineating proximal tubule response to chemical insult.
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Maxwell, Lynne. "Women's perceptions of factors that enhance and inhibit adaptation to chronic hemodialysis when renal transplantation is not an option." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28768.

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Factors Influencing Women's Adaptation to Hemodialysis When Renal Transplantation is not an Option The intent of this study was to explore and describe factors that influence adaptation from the perspective of women on hemodialysis for whom renal transplantation is not an option. Phenomenology was the research design selected for this study in order to understand the experience of these women clients. Data were collected during audio-taped interviews of eight women and were analyzed concurrently with data collection to identify common themes. Two central themes emerged: the adaptation process and the theme of connectedness. The adaptation process was described as a six-phase process. Connectedness was defined as being connected to others and/or sources of life's energy. Several key factors that either facilitated or interfered with adaptation were identified for each of these two themes. Key factors that facilitated adaptation throughout the adaptation process Included a first run on dialysis, experience with adversity, emotional and instrumental support, coping behaviors such as asserting control and reframing the situation, diversions, adequate rest and confidence in health-care professionals. Factors interfering with adaptation to hemodialysis throughout the adaptation process included the gradual and ambiguous nature of renal disease, increasing dependence, reduced energy, transportation to dialysis, compromised somatic health, difficulty with assertiveness, prolonged stressors and lack of confidence in health-care professionals. Specific factors that influenced connectedness were identified. The facilitating factors identified were satisfactory relationships, nurturing others, normalizing, a harmonious atmosphere on the hemodialysis unit and pleasurable activities. Key factors interfering with adaptation related to the connectedness theme were isolation from others, unsympathetic others, ineffective communication with health-care professionals, and exclusion from activities. The findings relative to the adaptation process were discussed in the light of the literature on adapting to illness and stress. Connectedness was discussed primarily in relation to the literature exploring the socialization of women. Implications for nursing practice, education and research arising from these findings were outlined.
Applied Science, Faculty of
Nursing, School of
Graduate
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Brunmark, Charlott. "Type IV collagen and renal disease." Lund : Dept. of Nephrology, University of Lund, 1994. http://books.google.com/books?id=owdrAAAAMAAJ.

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Sheehan, Susan. "Exploring the Genetics Regulating Kidney Function." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/SheehanS2007.pdf.

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Meadows, Susan Dove. "PERSISTENT NEPHROTOXICITY AND RENAL TUMOR PROMOTION IN SWISS-WEBSTER MICE FOLLOWING EXPOSURE TO 1,2-DICHLOROVINYLCYSTEINE (KIDNEY, CANCER)." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275292.

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潘建基 and Kin-kee Pun. "Carbohydrate metabolism in chronic renal and liver disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1986. http://hub.hku.hk/bib/B31981276.

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MIRANDA, ADRIANA R. "Avaliação da expressão e localização da conexina 43 na injúria isquêmica renal aguda." reponame:Repositório Institucional do IPEN, 2011. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10008.

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Dissertação (Mestrado)
IPEN/D
Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP
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Wang, Yang. "Murine adriamycin-induced nephropathy : the roles of cell-mediated immunity and CD4+ T-lymphocytes." Thesis, The University of Sydney, 2000. https://hdl.handle.net/2123/27827.

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Books on the topic "Kidneys – Diseases"

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1950-, Greenberg Arthur, and Cheung Alfred K, eds. Primer on kidney diseases. 5th ed. Philadelphia, PA: Saunders/Elsevier, 2009.

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W, Schrier Robert, and Gottschalk Carl W, eds. Diseases of the kidney. 5th ed. Boston: Little, Brown, 1993.

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Adamec, Christine. The encyclopedia of kidney diseases and disorders. New York, USA: Facts on File, 2012.

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Stewart, Cameron J., and Rees A. J, eds. Oxford textbook of clinical nephrology. Oxford: Oxford University Press, 1992.

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1950-, Greenberg Arthur, Cheung Alfred K, and National Kidney Foundation, eds. Primer on kidney diseases. 2nd ed. San Diego: Academic Press, 1998.

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1950-, Greenberg Arthur, and National Kidney Foundation, eds. Primer on kidney diseases. San Diego: Academic Press, 1994.

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A, Whitworth Judith, and Lawrence J. R, eds. Textbook of renal disease. Melbourne: Churchill Livingstone, 1987.

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International, Congress on Nephrology (11th 1990 Tokyo Japan). Nephrology: Proceedings of the XIth International Congress of Nephrology. Tokyo: Springer-Verlag, 1991.

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Wardener, H. E. De. The kidney: An outline of normal and abnormal function. Edinburgh: Churchill-Livingstone, 1985.

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Gabriel, Roger. Renal medicine. 3rd ed. London: Baillière Tindall, 1988.

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Book chapters on the topic "Kidneys – Diseases"

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Rayner, Hugh C., Mark E. Thomas, and David V. Milford. "Acid, Base and the Kidneys: The Role of the Kidneys in Acid-Base Disorders." In Understanding Kidney Diseases, 219–41. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-43027-6_15.

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Zarnow, Hilary, and Lawrence R. Bigongiari. "Parenchymal Diseases of the Kidneys." In Radiology of the Upper Urinary Tract, 71–101. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-84189-7_3.

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Roy, Jean-Philippe. "Liver Failure and the Kidneys." In Liver Diseases in the Pediatric Intensive Care Unit, 81–91. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-79132-2_5.

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Avni, Fred E. "Imaging Cystic Kidneys in Children." In Diseases of the Abdomen and Pelvis 2010–2013, 239–42. Milano: Springer Milan, 2010. http://dx.doi.org/10.1007/978-88-470-1637-8_33.

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Rayner, Hugh C., Mark E. Thomas, and David V. Milford. "Are You Pregnant or Planning a Pregnancy? How Pregnancy Affects the Kidneys and Vice Versa." In Understanding Kidney Diseases, 87–94. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-43027-6_7.

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Minuk, Howard L. "Diseases of the Kidneys and Urinary Tract." In Brackenridge’s Medical Selection of Life Risks, 611–54. London: Palgrave Macmillan UK, 2006. http://dx.doi.org/10.1007/978-1-349-72324-9_24.

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Minuk, Howard L. "Diseases of the Kidneys and Urinary Tract." In Brackenridge’s Medical Selection of Life Risks, 611–54. London: Palgrave Macmillan UK, 2006. http://dx.doi.org/10.1007/978-1-349-56632-7_24.

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Minuk, Howard L. "Diseases of The Kidneys and Urinary Tract." In Medical Selection of Life Risks, 569–607. London: Palgrave Macmillan UK, 2000. http://dx.doi.org/10.1007/978-1-349-14499-0_25.

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Zagoria, R. J. "Obstruction and Infection of the Kidneys and Ureters." In Diseases of the Abdomen and Pelvis, 202–5. Milano: Springer Milan, 1999. http://dx.doi.org/10.1007/978-88-470-2141-9_36.

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Müller, Andreas, and Martin Meier. "Assessment of Renal Volume with MRI: Experimental Protocol." In Methods in Molecular Biology, 369–82. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0978-1_21.

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AbstractRenal length and volume are important parameters in the clinical assessment of patients with diabetes mellitus, kidney transplants, or renal artery stenosis. Kidney size is used in primary diagnostics to differentiate between acute (rather swollen kidneys) and chronic (rather small kidney) pathophysiology. Total kidney volume is also an established biomarker in studies for the treatment of autosomal dominant polycystic kidney disease (ADPKD). There are several factors influencing kidney size, and there is still a debate on the value of the measured kidney size in terms of renal function or cardiovascular risk. The renal volume is most often calculated by measuring the three axes of the kidney, on the assumption that the organ resembles an ellipsoid. By default, the longitudinal and transverse diameters of the kidney are measured. In animal models renal length and volume1 are also important parameters in the assessment of organ rejection after transplantation and in determination of kidney failure due to renal artery stenosis, recurrent urinary tract infections, or diabetes mellitus. In general total kidney volume (TKV) is a valuable parameter for predicting prognosis and monitoring disease progression in animal models of human diseases like polycystic kidney disease (PKD) or acute kidney injury (AKI) and chronic kidney disease (CKD).This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol is complemented by two separate chapters describing the basic concept and experimental procedure.
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Conference papers on the topic "Kidneys – Diseases"

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Radbruch, AH, G. Cassese, S. Lindenau, B. De Boer, S. Arce, A. Hauser, G. Riemekasten, C. Berek, F. Hiepe, and RA Manz. "OP0076 Kidneys of autoimmune nzb/w mice contain long-lived pc." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.1240.

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SHEN, M. C., S. H. CHEN, and K. S. LIN. "TWO CASES OF NEONATAL PURPURA FULMINANS HOMOZYGOUS FOR PROTEIN C DEFICIENCY IN A CHINESE FAMILY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644308.

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Protein C (PC) deficiency associated with hereditary venous thromboembolic disease was first reported in 1981 and is inherited as an autosomal dominant disorder. The prevalence of heterozygous PC deficiency is estimated to be 1 to 4% in venous thrombotic diseases. The homozygous PC deficiency is even rare, and has been reported in only about 10 families througout the world. It usually presents in newborn infants as purpura fulminans or severe thrombotic disease. We herein report two newborn brothers in a Chinese family, who manifested with purpura fulminans soon after birth and died at age of 21 days and 27 days respectively. Vitamin K was administered to the second baby after birth. Both parents are not consanguineous and there were no family histories of thromboembolism on paternal and maternal sides. Blood sample was not available for specific studies in the first baby. PC antigen level by electroimmunoassay was <6% in the second baby and 49% and 60% respectively in their mother and father. Antithrombin III activity by amidolytic method was 49% in the second baby, and 90% and 97% respectively in their mother and father. Vitamin K-dependent coagulation factors and factor V were within the expected range for a newborn. Factor VIII and fibrinogen level were notably decreased. Autopsy findings of the two newborns demonstrated the similar pictures characterized by fibrin thrombi in blood vessels causing extensive hemorrhagic infarts of skin, lung, liver, kidneys, testis, urinary bladder, esophagus and brain. Our Data indicate that neonatal purpura fulminans can be familial and caused by severe homozygous PC deficiency.
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Elsayed, Basant Moustafa, Lina Altarawneh, Suhail Doi, and Tawanda Chivese. "Association between pre-existing conditions and hospitalization, intensive care services and mortality from COVID-19 – a cross sectional analysis of an international global health data repository." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0151.

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Objective: To investigate the association between pre-existing conditions and hospitalization, need for intensive care services (ICU) and mortality due to COVID-19. Methods: We used data on all cases recorded in the Global Health Data repository up to the 10th of March 2021 to carry out a cross-sectional analysis of associations between cardiovascular diseases (CVD), hypertension, diabetes, obesity, lung diseases and kidney disease and hospitalization, ICU and mortality due to COVID-19. We included data from Brazil, Mexico and Cuba only as they were the only countries where preexisting conditions were reported. We used multivariable logistic regression to compute adjusted and unadjusted odds ratios (OR) of the three outcomes for each pre-existing condition in ten-year age groups from 0-9 years and up to 110-120 years. Results: As of the 10th of March 2021, the Global Health repository held 25 900 000 records of confirmed cases of COVID-19, of which 2 900 000 cases from Brazil, Mexico and Cuba had data on preexisting conditions. The overall adjusted odds of hospitalization for each pre-existing condition were; CVD (OR 1.7, 95%CI 1.7-1.7), hypertension (OR 1.5, 95%CI 1.4-1.5), diabetes (OR 2.2, 95%CI 2.1-2.2), obesity (OR 1.7, 95%CI 1.6-1.7), kidney disease (OR 5.5, 95%CI 5.2-5.7) and lung disease (OR 1.9, 95%CI 1.8-1.9). The overall adjusted odds of ICU for each pre-existing condition were; CVD (OR 2.1, 95%CI 1.8-2.4), hypertension (OR 1.3, 95%CI 1.2-1.4), diabetes (OR 1.7, 95%CI 1.5-1.8), obesity (OR 2.2, 95%%CI 2.1-2.4), kidney disease (OR 1.4, 95%CI 1.2-1.7) and lung disease (OR 1.1, 95%CI 0.9-1.3). The overall adjusted odds of mortality for each pre-existing condition were; CVD (OR 1.7, 95%CI 1.6-1.7), hypertension (OR 1.3, 95%CI 1.3-1.4), diabetes (OR 2.0, 95%CI 1.9-2.0), obesity (OR 1.9, 95%CI 1.8-2.0), kidney disease (OR 2.7, 95%CI 2.6-2.9) and lung disease (OR 1.6, 95%CI 1.5-1.7). The odds of each outcome were considerably larger in children and young adults with these preexisting conditions than for adults, especially for kidney disease, CVD and diabetes. Conclusion: Individuals with CVD, hypertension, diabetes, obesity, lung diseases and kidney diseases have high odds of hospitalization, ICU and mortality from COVID-19. The odds of these outcomes are especially elevated in children and young adults with these preexisting conditions
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Huang, Zhongping, Jie Ren, and Anilchandra Attaluri. "Experimental Study of a Hybrid Renal Replacement System." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14326.

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Kidney failure is a major issue in the United States. The numbers of kidney failure patients are rapidly increasing with the simultaneous rise in diabetes, obesity and hypertension1. Kidney transplantation has shown excellent results, but insufficiency of donors has been a limiting factor. Most end-stage renal disease (ESRD) patients depend on hemodialysis (HD) for survival which is highly expensive. On an average ESRD patients receive 3 dialysis treatment a week and 4 hours per treatment, i.e., approximately 12 hours a week. Technology has not yet reached to a state where all the kidney functions can be mimicked. The only major kidney function being performed in HD is toxin removal. Even the toxins are not being continuously removed from the patients. To compensate the toxin and fluid removal of a whole week within 12 hours, high volumes of fluid are removed in HD treatments. Patients suffer due to the high fluid removal in a short period of time. Also the patients are restricted from taking fluids between the HD treatments. More frequent HD can improve both survival rate and life quality of patients with chronic kidney disease since normal people has his kidneys functioning continuously. It is a well known fact that daily dialysis offers many benefits over regular intermittent HD1. But providing daily dialysis is not affordable currently. Therefore, new modes of delivering continuous renal support are required.
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Yadykina, T. K., N. N. Mikhailova, and A. G. Zhukova. "BIOMEDICAL ASPECTS OF THE FORMATION OF METABOLIC MALADAPTATION IN CHRONIC OCCUPATIONAL INTOXICATION WITH FLUORIDE COMPOUNDS." In The 17th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2023). FSBSI «IRIOH», 2023. http://dx.doi.org/10.31089/978-5-6042929-1-4-2023-1-535-539.

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Long-term exposure to fluorides on the body of aluminum production workers is a determining factor in the development of chronic occupational intoxication with fluorine compounds, the pathogenetic mechanisms of which have not been studied enough. The systemic aspects of its course remain open. The aim — on the basis of experimental and clinical genetic data to study the medical and biological aspects of the formation of metabolic maladaptation in the dynamics of fluoride intoxication. Material and methods. The study included 370 metallurgists with occupational pathology and a comparison group, n=127, with individual signs of fluorine exposure to the skeleton. Bone mineral density was studied. Real-time PCR evaluated the association of VEGF and GST gene polymorphisms with the risk of developing intoxication, diseases of the circulatory system, liver pathology, and renal dysfunction. The experiment was simulated with 12 weeks of free access of rats, n=130, to NaF solution, 10 mg/l. Western-blot analysis in the cytosolic fraction of the liver, kidneys, heart studied the level of HIF‑1α, HSP72, HSC73, HOx‑1,2. In the blood plasma and homogenate of the studied organs, the activity of metabolic enzymes was determined: alkaline and acid phosphatases, α-glycerophosphate dehydrogenases, alanine-, aspartate aminotransferases, cholinesterases, γ-glutamyltranspeptidase, catalase, superoxide dismutase lactate-, hydroxybutyratedehydrogenases. Results. A clinical and experimental study showed the development of specific metabolic changes in the dynamics of fluoride intoxication and their relationship with degenerative-dystrophic changes in the skeleton. The association of the GC VEGF, GSTT1, M1 0/0 genotype with the risk of developing comorbid pathology was determined. The experiment shows that the response to NaF develops in waves. In the early stages, the expression of protective proteins and metabolic enzymes in hepatocytes increases. Compensatory reactions are provided by increased cytochemical activity. From the 6th week, the structure of the liver and kidneys is disturbed. In the heart of rats, activation of the redox signaling system and antioxidant protection was noted, which reduces the intensity of free radical processes and preserves the structure of the myocardium up to the 3rd week. Further, the imbalance of compensatory mechanisms is determined against the background of activation of free radical oxidation, degenerative changes in cardiomyocytes, 9 weeks. Conclusions. The leading pathogenetic link in the formation of a chain of systemic pathological reactions in fluoride intoxication is maladaptive shifts in homeostasis parameters associated with individual risk.
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Chu, Sauman, Allyson Hart, and Marilyn Bruin. "A patient-centered approach in designing a kidney transplant decision aid." In AHFE 2023 Hawaii Edition. AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1004234.

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The kidney transplant decision aid tool (https://www.srtr.org/tools/kidney-transplant-decision-aid/) was designed, created, and included as part of the Scientific Registry of Transplant Recipients (SRTR) resource website. The decision aid tool was created with input from patients with kidney disease and the doctors who care for them. An extensive information gathering and testing process with user-centered approach was implemented. Ten interviews and 4 focus group discussion sessions were held with an average of 4.5 patients in each group to gather preliminary design and content directions. Two additional focus groups with a total of 12 kidney transplant providers and 4 additional national focus group discussions with a total of 19 patients were held afterward to discuss the created content and design approach. Finally, 15 individual patient testing sessions were conducted to refine the content, design, and navigation of the tool. The tool is intended to be used during patient’s visit with their doctor as the patient learns about kidney transplant. Our goal is to provide informative materials to empower patients by helping them understand treatment options and outcomes. The doctor will guide patient through the tool and explain the information to help them to make informed decisions.The decision aid tool contains concise information to compare the pros and cons of dialysis vs. transplant treatments, living donor vs. deceased donor transplant, accepting higher quality vs. lower quality deceased donor kidney offers, and increased infectious risk kidneys vs. standard infectious risk kidneys. We also created a calculator to estimate a patient’s likely outcomes on the kidney transplant wait list based on the transplant regions or center and the individual’s medical condition. Preliminary testing suggests that patients find the tool and the likely outcomes helpful in leading to informative decision making.
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Adress ALNUIMY, Arwa. "LONG-TERM PATHOLOGICAL SIDE EFFECTS OF INFECTION WITH THE COVID-19 VIRUS IN THE MOSUL CITY." In IV.International Scientific Congress of Pure,Appliedand Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress4-14.

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Background: The world witnessed a crisis that swept out almost all of humanity's future, namely the spread of a coronavirus virus known as Covid19 Although it is a microorganism that cannot be seen with the naked eye and parasitizes on humans, animals and plants, it is the cause of a universal crisis in which people have been forced to stop their lives and stay in homes, Just as it has been disastrous for public health, it has disrupted health care systems and daily life , COVID-19 had spread at the end of 2019 in Wuhan, Hunan Province, where the seafood market is. The virus is spread quickly and later reach to all parts of the world , The impact of Covid-19 was not only severe, but it also caused complex long-term complications as a result of the complexity of the virus itself, and the virus had lasting effects on physical and psychological public health, Despite the complex negative complications caused by Covid-19, we can understand some of the mechanisms that cause these complications from the repercussions of the long-term negative effects caused by the types of Corona viruses that preceded Covid-19, namely SARS and MERS , But this requires raising awareness and conducting more studies to find out how to effectively manage the severe consequences caused by COVID-19 and to benefit from previous lessons in order to achieve the best results. Objectives: The study was conducted to identify long-term negative effects of Covid19 infection in the city of Mosul, the center of the Iraqi governorate of Nineveh. Methods: The number of sample members from whom the data was collected was 510 people of both sexes and of all ages, recording as many statistics as possible that illustrate the side effects of a covid - 19 infection. When we finished collecting the data and verifying that there are no errors, we conducted an analysis of these data and this statistical analysis of the data comes for the purpose of extracting and interpreting the results. The Statistical Package for Social Sciences (SPSS) v.20 was used to find tables and columns for frequencies and percentages. Results: The study has shown that Covid19 infection has many long-term negative effects on many organs and systems in the body and it is one of the most important results of our study, The study found that the highest age group involved in the study was between 36-45, with a percentage of 39.2%, The percentage of females is higher than males at 68.6% , As for the negative effects, Covid-19 caused damage to the lungs and chronic bronchitis had the highest rate of 29.4% , As for the long-term effects of Covid-19 infection on the kidneys, Cystoureteropyelitis was the highest with a rate of 44.1% , While Tachycardia had the highest percentage of cardiovascular diseases with a rate of 67.1% , On the side of neurological diseases, chronic headache was the highest, and it was 60.6% , As for skin diseases, the percentage was 38%, the largest was Lipsotrichia , In Ophthalmology, 69.9% of the share of Blurred vision, and ear diseases Oxyacoia has 51.2% , As for mental illnesses, there were many diseases, and the highest percentage was Anxious 22.1% , As for other diseases, Nervous colon was the highest with a rate of 15.9%, and for many other diseases, with different rates. Conclusion: The results of the study conducted in the city of Mosul showed that Covid19 infection caused many long-term illnesses that must concerted efforts to get the best results in their treatment
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Никитенко, О. П., Т. В. Стоева, М. В. Федин, and А. И. Гоженко. "ЭТИОЛОГИЯ И ОСОБЕННОСТИ ТЕЧЕНИЯ ХБП У ДЕТЕЙ ПРИ ПАТОЛОГИИ МОЧЕВЫДЕЛИТЕЛЬНОЙ СИСТЕМЫ." In International Trends in Science and Technology. RS Global Sp. z O.O., 2021. http://dx.doi.org/10.31435/rsglobal_conf/28022021/7434.

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This article presents data on the development of (chronickidney disease) CKD in children.In particular, with the pathology of the urinary system in children of different age groups.We analyzed the main clinical characteristics and laboratory parameters in children with pathology of the urinary system.The main parameters of the functional state of the kidneys were considered, the glomerular filtration rate (GFR) was calculated using the CKD EPI formula.The chronic pathology of the urinary systemin children was also analyzed.The course of CKD in children with various clinical nosological forms of kidney pathology was studied.
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Amiri, Manouchehr, and Sorosh Amiri. "Increased Efficiency in Spontaneously Passing Kidney Stones Using a Novel Ureteral Double-J Stent." In ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-24406.

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Abstract Kidney stones are stiff deposit minerals formed in the kidneys. In patients with kidney stones disease, double-J stents are used to increase the openness of the ureter in case of blockage by the kidney stones. The stent surfaces are normally smooth with symmetric friction along the longitudinal axis. In this work, we show that a modified double-J stent with asymmetric friction surface facilitates passage of stone fragments after extracorporeal shock wave lithotripsy or trans ureteral lithoclast. To examine the effect of asymmetric friction on the stone passing efficiency, finite element simulations were conducted. Simulation results revealed that at excitation vibration frequency of 0.15 Hz the stone unidirectionally moves along the stent at an average speed of 0.03 cm/s which is a significant increase compared to the clinical reports. Practically, the asymmetric friction can be made by laser micro-engraving techniques such as the same method in CD writing.
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Rebouças Filho, Pedro Pedrosa, Suane Pires Pinheiro Da Silva, Jefferson Silva Almeida, Elene Firmeza Ohata, Shara Shami Araujo Alves, and Francisco Dos Santos Hercules Silva. "An Approach to Classify Chronic Kidney Diseases using Scintigraphy Images." In XXXII Conference on Graphics, Patterns and Images. Sociedade Brasileira de Computação - SBC, 2019. http://dx.doi.org/10.5753/sibgrapi.est.2019.8318.

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Chronic kidney diseases cause over a million deaths worldwide every year. One of the techniques used to diagnose the diseases is renal scintigraphy. However, the way that is processed can vary depending on hospitals and doctors, compromising the reproducibility of the method. In this context, we propose an approach to process the exam using computer vision and machine learning to classify the stage of chronic kidney disease. An analysis of different features extraction methods, such as Gray-Level Co-occurrence Matrix, Structural Co-occurrence Matrix, Local Binary Patters (LBP), Hu's Moments and Zernike's Moments in combination with machine learning methods, such as Bayes, Multi-layer Perceptron, k-Nearest Neighbors, Random Forest and Support Vector Machines (SVM), was performed. The best result was obtained by combining LBP feature extractor with SVM classifier. This combination achieved accuracy of 92.00% and F1-score of 91.00%, indicating that the proposed method is adequate to classify chronic kidney disease in two stages, being a high risk of developing end-stage renal failure and other outcomes, and otherwise.
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Reports on the topic "Kidneys – Diseases"

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Zhang, Mingzhu, Wujisiguleng Bao, Luying Sun, Zhi Yao, and Xiyao Li. Efficacy and safety of finerenone in chronic kidney disease associated with type 2 diabetes: meta-analysis of randomized clinical trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0020.

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Review question / Objective: To assess the beneficial effect and safety of finerenone for patients with chronic kidney disease associated with type 2 diabetes. Condition being studied: Chronic kidney disease (CKD) is a major contributor to morbidity and mortality from non-communicable diseases, affecting almost 700 million people worldwide. Approximately 40% of patients with diabetes have CKD, which exposes them to a 3-fold higher risk of cardiovascular death versus those with T2D alone. Strategies to protect the kidneys of patients with CKD and T2D may reduce their risk of cardiovascular events. Finerenone, a nonsteroidal, selective mineralocorticoid receptor antagonist, reduced composite kidney and cardiovascular outcome in trials involving patients with chronic kidney disease. Recently, quite a few clinical studies have been conducted to compare finerenone and placebo. Our meta-analysis aimed to investigate the efficacy and safety of finerenone in chronic kidney disease associated with T2D. 1st author* - Mingzhu Zhang and Wujisiguleng Bao contributed equally to this study.
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Hua, Zi Bo, and Lv Yuan Chen. Human UCB MSC versus placebo for effect on kidney fibrosis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0104.

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Review question / Objective: Human UCB MSC versus placebo for effect on kidney fibrosis Condition being studied: Renal fibrosis is the final outcome of long-term chronic kidney disease, and the kidney will lose its basic function. This experiment will explore the effect of Human UCB MSC for effect on kidney fibrosis. Main outcome(s): Correlation analysis of Human UCB MSC treatment on renalfibrosis.
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Nelson, Julie. Feline chronic kidney disease: Pathophysiology and diagnosis. Ames (Iowa): Iowa State University, January 2021. http://dx.doi.org/10.31274/cc-20240624-721.

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Corey Goldman, Corey Goldman. What's Calcium's role in heart and kidney disease? Experiment, December 2013. http://dx.doi.org/10.18258/1719.

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Gusella, Gabriele L. Role of Integrin-Beta1 in Polycystic Kidney Disease. Fort Belvoir, VA: Defense Technical Information Center, April 2012. http://dx.doi.org/10.21236/ada562319.

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Dominguez, Jesus, K. J. Kelly, and Jizhong Zhang. Intravenous Renal Cell Transplantation for Polycystic Kidney Disease. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada597871.

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Husidic, Dejvid. The Effect of SGLT-2 Inhibitors in Non-Diabetic Patients with Diseases Such as Congestive Heart Failure and Chronic Kidney Disease. Ames (Iowa): Iowa State University, May 2022. http://dx.doi.org/10.31274/cc-20240624-1425.

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Horvit, Andrew, and Donald Molony. A Systematic Review and Meta-Analysis of Mortality and Kidney Function in Uranium – Exposed Individuals. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0122.

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Review question / Objective: 1) In humans, how does environmental and/or occupational exposure to uranium affect the risk of mortality due to primary kidney disease compared to unexposed individuals? (2) In humans, how does environmental and/or occupational exposure to uranium affect the risk of developing kidney failure compared to unexposed individuals? Eligibility criteria: We included cohort studies that evaluate the risk of CKD/ESKD due to uranium exposure. We also included cohort studies that evaluate standardized mortality due to all-cause mortality, kidney cancer, chronic kidney disease, diabetes, and cardiovascular disease in humans with exposure to uranium. We also included cross sectional studies that evaluate renal function in humans exposed to uranium via biomarkers and hard clinical measures (such as creatinine clearance) compared to humans with low/no uranium exposure. In order to not include the same cohort multiple times in the statistical analyses, we selected studies that evaluated an outcome of interest for a given cohort for the longest follow-up period. When this was not possible (due to multiple studies using different combinations of cohorts with varying lengths of follow up), the study with the largest study population size was selected.
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Gusella, Gabriele L. Role of Integrin-Beta 1 in Polycystic Kidney Disease. Fort Belvoir, VA: Defense Technical Information Center, April 2011. http://dx.doi.org/10.21236/ada555405.

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Tomko, Lainey. Current Perspectives on Chronic Kidney Disease in Veterinary Medicine. Ames (Iowa): Iowa State University, May 2024. http://dx.doi.org/10.31274/cc-20240624-460.

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