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1

McGarraghy, Michelle. Ketones and isocyanates: Conerted catalysis. Dublin: University College Dublin, 1996.

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2

Mason, Craig. Hydrazinolysis of cyclic [alpha]-nitro ketones. Sudbury, Ont: Laurentian University, 1993.

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3

Venner, Mark Ralph William. Studies in deracemisation of racemic ketones. Birmingham: Universityof Birmingham, 1992.

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4

United States. Agency for Toxic Substances and Disease Registry. Division of Toxicology. 2-hexanona. Atlanta, GA: Departamento de Salud y Servicios Humanos de los EE.UU., Servicio de Salud Pública, Agencia para Sustancias Tóxicos y el Registro de Enfermedades, 1992.

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5

United States. Agency for Toxic Substances and Disease Registry. Division of Toxicology. Isoforona. Atlanta, Ga.]: Agencia para Sustancias Tóxicas y el Registro de Enfermedades, División de Toxicología, Departamento de Salud y Servicios Humanos de los EE.UU., Servicio de Salud Pública, 1989.

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6

United States. Agency for Toxic Substances and Disease Registry. Division of Toxicology. Isophorone. Atlanta, Ga]: U.S. Dept. of Health and Human Services, Agency for Toxic Substances and Disease Registry, Division of Toxicology, 2003.

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7

Walsh, Sinead M. The tautomerisation and isomerisation of [alpha]-heterocyclic ketones. Dublin: University College Dublin, 1998.

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8

Nispen, Reinier van. Photochemistry and spectroscopy of some steroidal [beta], [gamma]-unsaturated ketones: A geometry-photoreactivity study. Alblasserdam: Offsetdrukkerij Haveka B.V., 1992.

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9

Reisinger, Corinna. Epoxidations and Hydroperoxidations of α,β-Unsaturated Ketones. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28118-1.

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10

Gmehling, JÜrgen. Vapor-liquid equilibrium data collection: Ketones : supplement 1. Frankfurt-am-Main: DECHEMA, 1993.

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11

Marciniak, Bronisław. Badania mechanizmu sensybilizowanej fotoredukcji 1,3-diketonianów metali w roztworach. Poznań: Wydawn. Nauk. Uniwersytetu im. A. Mickiewicza w Poznaniu, 1989.

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12

Kimpe, Norbert De. The chemistry of &-haloketones, &-haloaldehydes and &-haloimines. Chichester, England: Wiley, 1988.

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13

Nenajdenko, Valentine G. Chemistry of [alpha], [beta]-unsaturated trifluoromethly [i.e. trifluoromethyl] ketones. New York: Nova Science Publishers, Inc., 2007.

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14

Hallett, David James. Ally lstannanes: Reaction with imines, iminium ions and ketones. Manchester: University of Manchester, 1993.

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15

Hull, L. A. Analysis of aldehydes and ketones in the gas phase. Research Triangle Park, NC: U.S. Environmental Protection Agency, Atmospheric Sciences Research Laboratory, 1985.

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16

Kimpe, Norbert de. The chemistry of [alpha]-haloketones, [alpha]-haloaldehydes, and [alpha]-haloimines. Chichester: Wiley, 1988.

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17

Rathbun, R. E. Gas-film coefficients for the volatilization of ketones from water. Washington: U.S. G.P.O., 1986.

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18

Lee, Steger Joette, Radian Corporation, and United States. Environmental Protection Agency, eds. Field validation of the DNPH method for aldehydes and ketones: Final report. Research Triangle Park, N.C: Radian Corporation, 1996.

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19

Schäfer, Andrea. Ansa-Metallocene: Enantiomerentrennung und katalytische Aktivität bei der Reduktion von Ketonen. Konstanz: Hartung-Gorre, 1986.

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20

Fullbrook, Jeremy Jon. Generating structural diversity in a[alpha],a[alpha]-difluoromethyl ketones. Birmingham: University of Birmingham, 2002.

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21

Kubicki, Jacek. Spektralne i fotofizyczne właściwości wzbudzonych cząsteczek i krótko żyjących indywiduów przejściowych na przykładzie tioketonów i zasad Schiffa: Spectral and photophysical properties of tioketones and Schiff bases : excited molecules and transient species. Poznań: Wydawnictwo Naukowe Uniwersytetu im. Adama Mickiewicza, 2008.

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22

Frenkel, M., and K. N. Marsh, eds. Densities of Phenols, Aldehydes, Ketones, Carboxylic Acids, Amines, Nitriles, and Nitrohydrocarbons. Berlin/Heidelberg: Springer-Verlag, 2002. http://dx.doi.org/10.1007/b76771.

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23

Paju, Anne. Asymmetric oxidation of prochiral and racemic ketones by using sharpless catalyst. Tallinn: TTU Press, 2001.

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24

Norret, M. Synthetic approaches towards enantiopure axially-symmetric cyclic ketones and related compounds. Manchester: UMIST, 1996.

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25

Zerizer, Hafiza. Synthesis and photochemistry of B-amino-ketones and A-substituted succinimides. Salford: University of Salford, 1985.

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26

Brunet, Gaetan. Aluminum vapour synthesis: Reaction of A1 atoms with ketones at 77K. Sudbury, Ont: Laurentian University, 1993.

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27

International Program on Chemical Safety., International Labour Organisation, United Nations Environment Programme, and World Health Organization, eds. Methyl isobutyl ketone health and safety guide. Geneva: World Health Organization, 1991.

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28

Metwally, M. A. Cyclic beta-keto esters: Synthesis and reactions. Hauppauge, N.Y: Nova Science Publishers, 2009.

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29

Newport, Mary T. Alzheimer's disease: What if there was a cure? the story of ketones. 2nd ed. Laguna Beach, CA: Basic Health, 2013.

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30

Beeby, Andrew. The photochemistry and photophysics of aldehydes, ketones and simple sugars in solution. Norwich: University of East Anglia, 1988.

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31

Robert, Martin. Aromatic Hydroxyketones: Preparation and Physical Properties. Dordrecht: Springer Science+Business Media B.V., 2011.

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32

Simon, Eaton, and Fatty Acid Oxidation and Ketogenesis Conference (4th : 1998 : London, England), eds. Current views of fatty acid oxidation and ketogenesis: From organelles to point mutations. New York: Kluwer Academic/Plenum Publishers, 1999.

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33

Cossy, J., P. Vogel, S. von Angerer, T. S. Balaban, M. Yus, C. Njera, B. Figadre, et al. Ketones. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-026-00000.

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34

D’Agostino, Dominic P. Overview of Ketone-Based Metabolism. Edited by Dominic P. D’Agostino. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0031.

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Nutritional ketosis produces a nonpathological hyperketonemia resulting from decreased glucose availability, lower insulin, and increased fat oxidation. However, the restrictive nature of the ketogenic diet (KD) has limited the clinical applicability of therapeutic ketosis, due to practical considerations. Emerging data suggests that many of the benefits of the KD are mechanistically attributable to the ketone bodies or specific medium chain triglycerides, and this has motivated investigators to develop strategies to further augment the efficacy of the KD or use metabolic-based supplements to circumvent the need for dietary restriction to improve compliance and the maintenance of this therapeutic state. This section, “Ketone-Based Metabolism: General Health and Metabolic Alternatives,” includes chapters that discuss the expanding medical and performance applications of nutritional ketosis and the emerging science of ketones and other related metabolites as alternative fuels and potent signaling molecules.
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35

McIntyre, Phillip Edward. Autoxidation of Certain Ketones. Creative Media Partners, LLC, 2021.

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36

Cunnane, Stephen C., Alexandre Courchesne-Loyer, Valerie St-Pierre, Camille Vandenberghe, Etienne Croteau, and Christian-Alexandre Castellano. Glucose and Ketone Metabolism in the Aging Brain. Edited by Jong M. Rho. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0015.

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Brain glucose uptake is impaired in Alzheimer’s disease (AD). A key question is whether cognitive decline could be delayed if this defect were at least partly corrected or bypassed. Ketones (or ketone bodies) such as beta-hydroxybutyrate and acetoacetate are the brain’s main alternative fuels. Several studies have shown that in mild-to-moderate AD, brain ketone uptake is similar to that of healthy age-matched controls. Published clinical trials show that increasing ketone availability to the brain via nutritional ketosis has modest benefits on cognitive outcomes in mild-to-moderate AD and in mild cognitive impairment. Nutritional ketosis can be safely achieved by a high-fat ketogenic diet or supplements providing medium chain triglycerides. Given the acute dependence of the brain on its energy supply and the ineffectiveness of current therapeutic strategies for AD consideration be given to correcting the underlying problem of deteriorating brain fuel supply during aging.
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37

Poff, Angela M., Shannon L. Kesl, and Dominic P. D’Agostino. Ketone Supplementation for Health and Disease. Edited by Dominic P. D’Agostino. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0032.

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Exogenous ketone supplements rapidly elevate blood ketones in a dose-dependent manner regardless of dietary intake, making them a practical method of inducing therapeutic ketosis for medical use. It is thought that ketone supplementation could be used as a stand-alone therapy, or as a way to further augment the therapeutic efficacy of the ketogenic diet. Ketone supplementation could increase treatment compliance by allowing many patients to maintain a more normal lifestyle with a less restrictive diet. The therapeutic effects of ketone supplementation are likely mediated in part by a stabilization of blood glucose and insulin levels, an increase in metabolic efficiency, and an inhibition of oxidative stress and inflammation. Ketone supplements may also serve as an effective preventative medicine due to their potential ability to protect and enhance mitochondrial health and function. Indeed, preliminary evidence suggests there are a number of conditions for which exogenous ketone supplementation may be beneficial.
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38

Davis, Rose May 1894. Reactivity of Doubly-Conjugated Ketones. Creative Media Partners, LLC, 2021.

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39

Publishing, Zanzilly. Running on Ketones and Coffee. Independently Published, 2019.

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40

Reynolds, Charles. Ketones: Clean. Efficient. Body Fuel. Independently Published, 2020.

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41

Martin, Robert. Aromatic Hydroxyketones : Preparation and Physical Properties : Vol.1 : Hydroxybenzophenones Vol.2 : Hydroxyacetophenones I Vol.3: Hydroxyacetophenones II ... Hydroxypivalophenones and Derivatives. Springer, 2017.

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42

Xu, Kui, Joseph C. LaManna, and Michelle A. Puchowicz. Ketogenic Diet, Aging, and Neurodegeneration. Edited by Detlev Boison. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0024.

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The brain is normally completely dependent on glucose, but is capable of using ketones as an alternate energy source, as occurs with prolonged starvation or chronic feeding of a ketogenic diet. Research has shown that ketosis is neuroprotective against ischemic insults in rodents. This review focuses on investigating the mechanistic links to neuroprotection by ketosis in the aged. Recovery from stroke and other pathophysiological conditions in the aged is challenging. Cerebral metabolic rate for glucose, cerebral blood flow, and the defenses against oxidative stress are known to decline with age, suggesting dysfunction of the neurovascular unit. One mechanism of neuroprotection by ketosis involves succinate-induced stabilization of hypoxic inducible factor-1alpha (HIF1α‎) and its downstream effects on intermediary metabolism. The chapter hypothesizes that ketone bodies play a role in the restoration of energy balance (stabilization of ATP supply) and act as signaling molecules through the up-regulation of salvation pathways targeted by HIF1α‎.
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43

Padwa, A., V. Aggarwal, J. Richardson, C. O. Kappe, B. Zwanenburg, S. J. Collier, M. J. Dabdoub, et al. Heteroatom Analogues of Aldehydes and Ketones. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-027-00000.

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44

Nordin, Sofia. Asymmetric Transfer Hydrogenation of Aromatic Ketones. Uppsala Universitet, 2002.

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45

The Complete Book of Ketones: A Practical Guide to Ketogenic Diets and Ketone Supplements. Basic Health Publications, Inc., 2019.

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46

Newport, Dr Mary. The Complete Book of Ketones: A Practical Guide to Ketogenic Diets and Ketone Supplements. Basic Health Publications, Inc., 2019.

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47

Epoxidations And Hydroperoxidations Of Abunsaturated Ketones An Approach Through Asymmetric Organocatalysis. Springer, 2012.

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48

Zürich, Eidgenössische Technische Hochschule, ed. Biodegradation of mixtures of ketone vapours in biofilters for the treatment of waste air. 1994.

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49

Wright, Deborah E. Exogenous Ketones: Discover the Advanced Way to Losing Weight by Supplementing with an Exogenous Ketone. Independently Published, 2019.

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50

Streijger, Femke, Ward T. Plunet, and Wolfram Tetzlaff. Ketogenic Diet and Ketones for the Treatment of Traumatic Brain and Spinal Cord Injury. Edited by Jong M. Rho. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0016.

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Ketogenic diets (KD)—high in fat, adequate in protein, and very low in carbohydrates—were developed almost a century ago and are still used clinically for drug-resistant epilepsy and some rare metabolic disorders. Possible new indications for cancers, diabetes, obesity, and neurodegenerative disorders are being trialed in humans based on a growing body of preclinical data showing efficacy. However the underlying mechanisms of KD remain incompletely understood. This chapter focuses on the neuroprotective effects of KD after spinal cord injury (SCI) and traumatic brain injury (TBI), and discusses possible mechanisms of action. It considers the possible role of ketone bodies as alternative fuels for mitochondrial energy utilization and the actions of ketones outside the mitochondria as agonists of antioxidant and anti-inflammatory pathways. It places these into context with the known pathophysiology of SCI and TBI, and discusses possible roles of KD and ketone bodies for their treatment.
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