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1
Cheung, Tak-sum Thomas. "Comparison of spiral tomography (Scanora) with ridge mapping and plain film radiography for dental implant planning in partially dentate jaws." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25068581.
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Bin, Syed Omar Syed Nabil. "Osteoradionecrosis of the jaws: analysis of the evidence." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44661265.
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Wannfors, Karin. "Chronic osteomyelitis of the jaws." Stockholm : Kongl. Carolinska Medico Chirurgiska Institutet, 1990. http://catalog.hathitrust.org/api/volumes/oclc/24827817.html.
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Yang, Jun. "Reflex control of human jaw muscles by periodontal mechanoreceptors." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phy219.pdf.
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Copies of author's previously published articles inserted. Bibliography: leaves 169-219. Describes experiments to determine what factors affect the outcome of the reflex response of the jaw closing muscles to peridontal mechanoreceptive stimulus. The reflex responses of the human masseter were investigated by applying force using different stimulus profiles. It was shown that when the force profile had little or no fast component, the likelehood of eliciting an exitatory peridontal masseteric reflex increased. It is concluded that the shape of the stimulus profile, the location of the stimulating probe and the presence of preload are the main factors that determine the exitatory reflex response of the jaw closing muscles.
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Lueveswanij, Somyot. "A clinical study of 626 jaw cysts in southern Chinese patients." Thesis, Click to view the E-thesis via HKUTO, 1994. http://sunzi.lib.hku.hk/HKUTO/record/B38628478.
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Cheung, Tak-sum Thomas, and 張德森. "Comparison of spiral tomography (Scanora) with ridge mapping and plainfilm radiography for dental implant planning in partially dentatejaws." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31954212.
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Brinkworth, Russell Stewart Anglesey. "Response of the human jaw to mechanical stimulation of teeth." Access PDF text via HTML index, 2004. http://hdl.handle.net/2440/37934.
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Animal experiments indicate that the main form of feedback for jaw-closing muscles is from periodontal mechanoreceptors (PMRs). However, due primarily to limitations on methods, this is yet to be confirmed in humans. The main aim of this thesis was to investigate the reflex contribution of PMRs to the human jaws using vertical (axial) stimulation. To this end the electromyographic and bite force responses of the jaw to a number of different mechanical stimulus conditions, delivered to both the upper central incisors and the upper right first molars, were investigated. The principal hypothesis was that PMRs are responsible for the majority of the reflex responses seen in the human jaw muscles. Furthermore this reflex response is modulated by different characteristics of the stimulus such as: rate of rise, maximum force applied, the amount of constant offset force (preload), the level of muscle contraction and also the physical characteristics of the subject's jaw including: dental health and tooth spacing. These studies have contributed towards the understanding of the neuronal wiring and the receptor systems contained in the jaw. The results indicate that PMRs around the incisors are of fundamental importance for the development of reflex patterns but little if any PMR related reflexes exist around the molar teeth. The reflexes originating from the PMRs around the incisors are modulated by different mechanical characteristics of the stimulus, thus helping to explain how the jaw muscles perform numerous and complex patterns of activation which move the jaw in many different ways and develop forces that are optimum for the task at hand.Thesis (Ph.D.)--School of Molecular & Biomedical Science, 2004.
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MacDonald, David Stanislaw. "Fibro-osseous lesions affecting the jaws." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/24865.
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Fibro-osseous lesions (FOLs) affecting the jaws represent an important category both diagnostically and therapeutically. The overwhelming majority of cases of cemento-osseus dysplasia (COD) require no treatment, whereas its florid (affects more than one sextants of the jaw) form, in particular, raises significant risk of prosthodontic failure in the elder patient. The cemento-ossifying fibroma (COF) is a benign, occasionally aggressive, neoplasm requiring complete enucleation to obviate recurrence. Fibrous dysplasia (FD) is a harmatoma in most cases, but on occasion displays neoplastic behaviour. Diagnosis is normally achieved upon both clinical and radiological evaluation. Aims: Review the consecutive case of these lesions affecting a Hong Kong population, almost exclusively Chinese, whose oral lesions until only recently have not featured prominently in the international literature. Conduct a systematic review (SR) on the world literature pertaining to FOLs. Materials and Methods: all consecutive cases on CODs, COFs and FDs managed at the Dental School of the University of Hong Kong (HKU) from 1982 to 1992 for CODs and onwards to 2004 for COFs and FDs were identified. Results: Twenty-three Florid CODs, 6 Focal CODs, 24 COFs and 21 FDs (1 bimaxillary) were identified and their clinical and radiological features analysed and inserted into the SRs. All Florid CODs and COFs were female. Florid CODs identified as incidental findings and retained in radiology files were significantly younger than those derived from pathology files. COFs in the SR had significant predilections for females and the mandible and to be detected as radiolucencies, whereas the FD more significantly displayed radiologically, expansion of the buccolingual cortices, and of the lower border of the mandible. Clinically, the Florid CODs were significantly associated with pain, FDs were more significantly associated with swelling, FocCODs were also more significantly found incidentally.
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Hulsey, Christopher Darrin. "Functional micro and macroevolution in fish jaws /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.
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Pearce, Sophie. "Motor cortical control of human jaw muscles : a thesis submitted for the degree of Doctor of Philosophy in the Department of Physiology, the University of Adelaide, Adelaide, South Australia /." Title page, table of contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09php3595.pdf.
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Hoshyar, Ramesh Mohammad Alizadeh. "Immunocharacterisation of giant cell lesions of the jaws /." Title page, table of contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09DM/09dmh825.pdf.
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Thesis (M.D.S.)--University of Adelaide, Dept. of Dentistry, 1998?Addendum of text pasted on verso of Table of Contents. Addendum of references pasted on back fly-leaf. Includes bibliographical references (leaves 67-78).
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Chong, Mei-man, and 臧薇敏. "Three-dimensional comparison of the upper airway in various types of dentofacial deformities." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48542027.
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Objectives
1. To define the normative airway of Chinese population using three-dimensional imaging and computer analysis
2. To evaluate the upper airway differences in patients with normal facial profile and those with skeletal class III deformity
3. To evaluate the differences in upper airway models among patients with different dentofacial deformities and describe the role of computational fluid dynamics (CFD) in the human upper airway
Materials and Methods
Part I : Three-Dimensional Analysis of the Normative Upper Airway in Chinese
This was a cross-sectional observational study. Cone beam computerized tomography (CBCT) scans of one hundred patients were analyzed. Computer analysis of the different upper airway parameters were studied including airway length and volume, as well as airway dimensions at the axial level of the soft palate, hard palate, base of tongue, and epiglottis. The most constricted airway location was identified and correlation analysis with variables of interest was done.
Part II: A Cone Beam Computerized Tomography Study of Airway in Skeletal Class I and Class III
Cone-beam computed tomography (CBCT) records of 200 patients were used to evaluate the upper airway dimensions. This sample consisted of patients with normal facial profile (Class I) and those demonstrating skeletal class III deformities. Computer analysis of the upper airway parameters such as airway length, airway volume, airway anterior-posterior and cross-sectional area dimensions at the hard palate, soft palate, base of tongue and epiglottis were performed. The most constricted airway sites were identified.
Part III: Computational fluid dynamics study of upper airway in different dentofacial deformities
Cone-beam computed tomography records of 12 patients were used to evaluate the upper airway. This sample consisted of facial skeletal Class I, II and III subjects. The upper airway models were constructed to allow CFD simulations in the airway from the epiglottis to the hard palate. Cross-sectional area, pressure, velocity and resistance were measured based on the reconstructed meshed models.
Results
Part I : Three-Dimensional Analysis of the Normative Upper Airway in Chinese
In 100 subjects (40 males, 60 females) aged 16-40 years with normal facial profile, we found that the most constricted site occurs at the level of the soft palate. This surface area of this site was found to be linearly correlated to the airway volume, suggesting a significant relationship between the most constricted area and the total airway volume. Gender differences were found in airway length, volume, and in the dimensions at the base of tongue and epiglottis region. The mean airway length was 54.12 mm + 6.19 for males and 49.25 mm + 4.86 for females; airway volume of 15.09 cm3 + 4.92 for males and 13.12 cm3 + 4.72 for females.
Part II: A Cone Beam Computerized Tomography Study of Airway in Skeletal Class I and Class III
The sample consisted of 100 Class I (41 males, 59 females) with a mean age of 25.4 years and 100 Class III (38 males, 62 females) with a mean age of 23.5 years. Gender differences were noted in the airway length, airway volume and dimensions at the base of tongue and epiglottis for both groups. Males showed longer airway length, larger airway volume, larger airway dimensions at the base of tongue and epiglottis compared to females. Significant differences in all the airway parameters between the two groups were found except for airway length. The soft palate was found to be the most constricted airway site observed in the Class I subjects while Class III subjects showed restriction in both the soft palate and epiglottis region.
Part III: Computational fluid dynamics study of upper airway in different dentofacial deformities
The airflow was variable among airway in different skeletal deformities. The pressure changes along airway of Class II were the largest, followed by Class I. The pressure drop in the airway of Class III subjects were the smallest. The larger pressure differences would cause greater resistance in the airway. The highest resistance was observed in the airway of Class II subjects.
Conclusion
Part I : Three-Dimensional Analysis of the Normative Upper Airway in Chinese
This airway data provide a normative reference that can be used in various dentofacial analysis as well as for diagnosis and treatment planning for related dentofacial deformities and in understanding the pathophysiology for sleep-related breathing disorders.
Part II: A Cone Beam Computerized Tomography Study of Airway in Skeletal Class I and Class III
The upper airway is larger in patients with Class III deformity than those with a normal facial profile. The site of restriction is commonly observed at the soft palate in the Class I group whereas patients with Class III deformity, the airway restriction sites are at both the soft palate and epiglottis. Understanding of the upper airway differences in between class I and class III facial deformities can have implications on treatment planning for orthognathic surgery.
Part III: Computational fluid dynamics study of upper airway in different dentofacial deformities
The results in this study suggest that skeletal pattern showed a significant correlation with pressure and resistance along the upper airway.published_or_final_version
Dental Surgery
Master
Master of Dental Surgery
13
Holliday, Casey M. "Evolution and function of the jaw musculature and adductor chamber of archosaurs (crocodilians, dinosaurs, and birds)." Connect to this title online, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1147280827.
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Hariri, Firdaus. "Alveolar distraction osteogenesis for dental implant rehabilitation inreconstructed jaws." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44661514.
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Francis, Beryl. "Before and after Jaws: Changing representations of shark attacks." Thesis, Francis, Beryl (2011) Before and after Jaws: Changing representations of shark attacks. Honours thesis, Murdoch University, 2011. https://researchrepository.murdoch.edu.au/id/eprint/9471/.
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When the film Jaws (1975), about a rogue shark that terrorised a small seaside island community was released, it had an unprecedented paranoia effect on its audience that became entrenched into the psyche of bathers around the world; a fear that media hyperbole exploited. At the same time, the film was also responsible for a surge in scientific interest in sharks and the media responded by giving more attention to the important role of sharks in the marine ecology. In the long term, social perceptions of sharks, changed from fear to conservation, influencing local, national and international government conservation and management policies. Nevertheless, there persists the initial media frenzy after any shark attack and Jaws remains the touchstone for media reporting.
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Marks, Lori J. "Software Applications for the Blind: JAWS and Virtual Pencil." Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/3674.
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Castaldo, Lundén Elizabeth. "Jaws: Creating the Myth of the Man-Eating Machine." Thesis, Stockholms universitet, Filmvetenskapliga institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-89349.
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Jaws(Universal Studios, 1975) set a new standard for Hollywood film production byintroducing the concept of “summer blockbuster,” for a film that changed the way inwhich people thought about sharks. 37 years after the release of the movie, the idea of sharks as ferocious man-hunters still looms large in public opinion. Thisconceptualization of sharks as ruthless killers is mythical rather than factual, and thisresearch tracks the mechanisms that propelled the idea deep into popular culture.The dissertation addresses the problematics of media constructions through a casestudy of the movie Jawsdeparting from its production process, and by applyingBarbara Klinger’s interpretation of “epiphenomena.” The thesis studies how cinematravels into popular culture, by following the traces of the movie into other media, andits dialogue with the surrounding texts generated by PR, marketing andmerchandising; simultaneously, the thesis seek to demonstrate the connection between the movie as mythmaker and the stigmatized portrayal of sharks.
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Lee, Kin-man, and 李健民. "The management of unicystic ameloblastoma: effect of Carnoy's solution on recurrence rate." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B38628041.
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Ellis, Sally Diana. "The reproducibility of jaw movement." Thesis, The University of Sydney, 1989. http://hdl.handle.net/2123/4933.
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Li, Chunlei, and 李春蕾. "Role of periodontal diseases in bisphosphonate-related osteonecrosis of the jaws." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208556.
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Becconsall, Karyn, and n/a. "Analysis of radiolucent jaw lesions in a New Zealand population over a twenty-year period." University of Otago. School of Dentistry, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081202.144835.
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The maxilla and mandible may be affected by a wide variety of lesions of developmental, neoplastic or inflammatory origin. These lesions have a vast array of clinical and radiographic presentations from which a dentist forms a clinical provisional diagnosis and treats the lesions accordingly. The aim of this study was to determine the range, demographic and clinical features of all histologically diagnosed radiolucent jaw lesions in a New Zealand population over a twenty-year period. Additionally, the provisional diagnosis was compared to the histopathological diagnosis in an effort to gain an insight into the difficulties practitioners face in clinically diagnosing radiolucent jaw lesions.
Material and Methods: From the histopathology diagnostic service at the University of Otago School of Dentistry all specimens with a diagnosis of a radiolucent jaw lesion between 1986 and 2006 were retrieved and classified into six diagnostic categories. For each lesion the age, gender, site, clinical presentation, clinicians provisional diagnosis and the final histological diagnosis was gathered and analysed.
Results: During the study period 4983 specimens were identified as radiolucent jaw lesions. The diagnostic category with the largest number of specimens was inflammatory lesions (72.8%), followed by developmental odontogenic cysts (21.8%). Malignant tumours accounted for less than 1% of all specimens. Concordance of provisional and histopathological diagnoses ranged from 81.0% for nasopalatine duct cyst to 0% for the majority of intra-osseous malignant tumours.
Conclusions: The range and demographic features of radiolucent jaw lesions in this study are comparable to that of other populations with a European majority. No radiolucent jaw lesion can be reliably accurately diagnosed from clinical presentation and radiographic appearance alone.
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Sae-Lee, Daraporn. "Effects Of Experimentally Induced Jaw Muscle Pain On Jaw Muscle Activity And Jaw Movement During Standardized Jaw Tasks." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/4969.
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Singh, Baldev. "Prevalence of postoperative infection after orthognathic surgery." Thesis, Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23234635.
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Grykuliak, Glenna M. "Electroymyographic data and post-exercise pain in female muscle pain and control subjects after experimental chewing." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0002/MQ34370.pdf.
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Chan, Siew-luen, and 陳兆麟. "A cephalometric study of dentoalveolar hyperplasia in dentofacial deformities." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31953979.
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Mello, Patrícia Bicalho de [UNESP]. "Estabilidade esquelética da multisegmentação maxilar." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/123837.
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O objetivo desse estudo foi colaborar com o conhecimento atual sobre a estabilidade da multisegmentação maxilar que é controverso na literatura. Foram estudados aspectos relacionados à estabilidade esquelética, verificando-se possíveis relações da instabilidade com a amplitude dos movimentos cirúrgicos realizados, direção dos movimentos cirúrgicos realizados, tempo de acompanhamento e idade. TCFC digitalizadas antes e após cirurgia ortognática com osteotomia maxilar em forma de Y em 3 segmentos de 30 indivíduos em três momentos distintos foram analisadas (T1-pré-cirurgia; T2-pós-cirurgia imediata e T3- mínimo de 11 meses de acompanhamento). Os volumes tomográficos pré e póscirúrgicos foram superpostos, utilizando a base do crânio como referência para todos pacientes. Após a segmentação da maxila foi realizada a quantificação dos deslocamentos entre os modelos nos diferentes momentos por ICP (iterative closest point). Os valores médios dos deslocamentos e seus respectivos intervalos de confiança foram determinados por reamostragem não paramétrica; Man-Whitney para comparações duplas e Kruskal-Wallis para comparações múltiplas. Para as medidas de correlação, o coeficiente de correlação de Spearman foi calculado. Quanto maior a amplitude do deslocamento maior a instabilidade; a correlação da instabilidade com idade e tempo de acompanhamento foram muito pequenas...(Resumo completo, clicar acesso eletrônico abaixo)
The present study was undertaken to collaborate with up to date knowledge about the stability of maxillary multisegmentation that presents itself quite controversially in literature. Aspects related to skeletal stability were studied verifying the possible involvement of instability with the extent and direction of surgical movements performed and age. CBCT scanned before and after orthognathic surgery with maxillary osteotomy Y-shaped in 3 segments of 30 subjects at three different times were analyzed ( T1 - pre-surgery, T2 - immediate post operative and T3 - at least 11 months follow up) . Pre and postoperative CT volumes were superimposed using the base of the skull as a reference for all patients. After segmenting the maxilla, quantification of displacements between models at different moments was performed. The mean values of the desplacements and their respective confidence intervals were determined by nonparametric resampling; Man-Witney for double comparisons and Kruskal-Wallis for multiple comparisons. To measure the correlation, Spearman coefficient was calculated. As the displacement increase the instability increase; the correlation of instability with age and follow-up were very small.
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Suen, Ka-shing, and 孫嘉誠. "A prospective study of changes in psychosocial characteristics of patients with dentofacial deformities after corrective surgery." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50639675.
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Background: Jaw corrective surgery can cause significant psychosocial impacts on patients. This prospective study aimed to investigate the longitudinal changes of psychosocial characteristics of patients with dentofacial deformities after corrective surgery and the factors that predict the psychological resilience of Hong Kong Chinese undergoing this type of surgery.
Materials and Methods: A prospective cohort study was carried out from 1st June 2011 to 31st December 2012 on Hong Kong Chinese patients, who had corrective surgery as treatment for their dentofacial deformities. Self-completed questionnaires, including Brief Symptom Inventory (BSI), Adult Trait Hope Scale (AHS), Hospital Anxiety and Depression Scale (HADS), Life Orientation Test (LOT), Social Avoidance and Distress Scale (SADS) and Satisfaction with Life Scale (SWLS), were administered to each patient at the surgical consent signing date (T1), one pre-operative day (T2), 1-2 post-operative week (T3) and 3rd post-operative month (T4). Psychological outcome trajectories were established using the BSI General Severity index (GSI) at T1, T3 and T4. Five patterns of outcome trajectories were created using specified outcome measures of psychological distress level, including chronic dysfunction, recovery, delayed dysfunction, resilience and others. They were then categorized into two patterns of outcome trajectories (resilience and non-resilience groups) for analysis. Independence sample t-test and logistic regression analyses were conducted to investigate the significance of life orientation level at baseline to predict resilience.
Results: 67 participants (23 males, 44 females; mean age 25.6) were recruited in the study. Highest hope level and psychological distress level was noted pre-operatively at the surgical consent signing date. The levels then dropped post-operatively in the first 3 months. No statistically significant difference was noted on the depression and anxiety level, social avoidance and distress level, optimism level and life satisfaction level from pre-operative to post-operative stages. The proportion of the five patterns of outcome trajectories was chronic dysfunction (22.4%), recovery (7.5%), delayed dysfunction (3%), resilience (43.3%) and others (23.8%). The logistic regression analyses showed that the pre-operative baseline optimism level of LOT was a significant predictor on the resilience characteristic of a patient after orthognathic corrective surgery.
Conclusion: Patients with dentofacial deformities have high level of hope and equally high level of psychological distress at the surgical consent stage of orthognathic surgery. Their psychological distress and hope levels tend to drop during the first three post-operative months. There is no expected peri-operative change on the depression and anxiety symptoms, social avoidance and distress, optimism level as well as life satisfaction level in these patients. Optimism level can predict the psychological resilience of a Hong Kong Chinese in going through orthognathic surgery. Brief Symptom Inventory (BSI) and Life Orientation Test (LOT) are recommended as preoperative psychological screening tools.published_or_final_version
Dental Surgery
Master
Master of Dental Surgery
28
Chan, Siew-luen. "A cephalometric study of dentoalveolar hyperplasia in dentofacial deformities." [Hong Kong] : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B14019930.
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Steeve, Roger William. "Mandibular motor control during the early development of speech and nonspeech behaviors /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8220.
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Sebrén, Åsa, and Helena Nelson. "Medical treatment of chronic non-infectious osteomyelitis in the jaws. A systematic review." Thesis, Malmö universitet, Odontologiska fakulteten (OD), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19626.
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Syfte: Att systematiskt sammanfatta litteraturen inom området för medicinska behandlingsalternativ för icke-infektiös, kronisk osteomyelit i käkarna, utvärderat genom utläkning i ben och smärtlindring. Metod: En systematisk litteraturöversikt gjordes i fyra databaser; PubMed, Cochrane Library, Web of Science och Scopus. Översikten utfördes enligt instruktioner från ”PRISMA checklist” och ”CRD’s guidance”. En kvalitetsbedömning gjordes av samtliga inkluderade publikationer.Resultat: Sökningen resulterade i 2 100 artiklar. Efter urvalsprocessen återstod tre artiklar som inkluderades i denna systematiska litteraturöversikt. Samtliga studier utvärderade olika typer av bisfosfonatbehandlingar – ibandronat, pamidronat och disodium clodronat. Den smärtlindrande effekten utvärderades i alla tre studierna och utläkningen av benet utvärderades i två av artiklarna. Konklusion: Behandling av icke-infektiös osteomyelit med bisfosfonater visar en reduktion av smärta. Dock är den smärtlindrande effekten beroende på typen av bisfosfonat. Resultaten gällande utläkningen av ben är tvetydiga och därför kan ingen konklusion gällande detta göras. Endast en artikel ansågs i kvalitetsgranskningen ha hög kvalitet. För att kunna ta fram tydliga, evidensbaserade riktlinjer gällande behandling av icke-infektiös osteomyelit behövs fler kliniska studier som håller hög kvalitet. Bisfosfonater verkar vara ett bra behandlingsalternativ av icke-infektiös osteomyelit. Ett alternativ till bisfosfonater, skulle kunna vara behandling med denosumab, som har liknande verkningsmekanism men kortare halveringstid. Dock krävs fortsatta studier inom detta område.Aim: To systematically review the literature of medical treatment alternatives of non-infectious chronic osteomyelitis in the jaws regarding bone healing and pain relief. Methods: A systematic literature search has been made in four databases; PubMed, Cochrane Library, Web of Science and Scopus. The review was performed with directions from the PRISMA checklist and CRD’s guidance. A quality assessment was made of the included studies.Results: The search resulted in 2 100 articles and after the selection process, only three articles were included in this review. The studies evaluated different types of bisphosphonates - ibandronate, pamidronate and disodium clodronate. The reduction of pain was evaluated in all three articles and the bone healing was assessed in two of the articles. Conclusion: Treatment of non-infectious osteomyelitis with bisphosphonates shows a reduction in pain. However, the pain-relieving effect is most probably dependent on the type of bisphosphonates. The results of bone healing assessed from Tc-scans are ambiguous and therefore no conclusion can be made. Only one article in this review was considered to have high quality in the quality assessment. To enable clear guidelines regarding treatment of non-infectious osteomyelitis, more clinical trials with high quality is desirable. In summary, bisphosphonates seem to be a good alternative in treatment of non-infectious osteomyelitis. An alternative to bisphosphonates might be treatment with denosumab, which have a similar mechanism of action but shorter half-life. However, further research is needed.
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Lim, Lydia. "An Immunohistochemical And Ultrastructural Study Of The Giant Cell Granuloma Of The Jaws." Thesis, Faculty of Dentistry, 1993. http://hdl.handle.net/2123/4324.
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Pelster-Wiebe, Richard. "In the jaws of death: Leon Caverly’s camera-history of World War I." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6663.
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This dissertation argues that a critical anti-war cinema emerged with the birth of the so-called war documentary during World War I. Focusing on Leon Caverly, the first official war cinematographer of the United States military, I that argue America’s first war propaganda films gave birth to America’s first anti-war cinema. Military-produced images of World War I are available in various archives such as the Library of Congress, the National Archives, and the Marine Corps History Center. In addition to unedited reels of war related footage, the archives hold propaganda films such as Pershing’s Crusaders (1918), America’s Answer (1918) and Under Four Flags (1918). These feature films were shot by cameramen in the Marines or the Signal Corps and then edited into works of propaganda by the United States Government’s Committee on Public Information. Caverly was the first cameraman to join the effort of filming at the front. While he was a Marine and an instrumental player in America’s propaganda program, he also completed a cinematic history of the Great War through his creative nonfiction camerawork that was more subtle and critical than conventional war documentaries would suggest.
Previous studies of World War I propaganda provide context for America’s cinematic efforts or profiles of individual cameramen. But little or no attention has been paid to formal analysis of the films themselves. Furthermore, scholars have not yet regarded these films as anything other than examples of early documentary or government propaganda. The same holds true concerning Leon Caverly. Not only was Caverly the first United States war cinematographer, but the most significant work of propaganda made during the war was composed of footage shot entirely by him. Released in 1918, America’s Answer captivated audiences in America and Europe, providing inspiration for the home front to support the war. However, a striking discrepancy exists between the content of Caverly’s shots and the rhetorical editing structure of the film. In contrast to the pro-war sentiment articulated by the editing and its intertitles, America’s Answer’s individual shots reveal a practice of camera-writing that represents an aesthetics of anti-war cinema at odds with pro-war propaganda.
Caverly’s work does not show the horrors of war with documentary realism. Nor does his work openly critique America’s war effort. Rather, Caverly aspires to be a camera-historian whose moving images and photographic work demonstrate a preoccupation with writing history steeped in the temporal aesthetics of the camera arts. This dissertation considers still and moving image practices that “write with time” such as double-exposures, shots that emphasize duration, moving camera shots that evoke temporal relationships, and framing that gives metaphorical expression to time. The fact that these practices appear in Caverly’s wartime work indicates that World War I footage has a greater significance for film history than simply exemplifying documentary realism or propaganda. This dissertation shows that, while the most harrowing aspects of World War I combat remain unseen in Caverly’s work, his creative camera-writing approaches war and the fragility of life in unconventional ways.
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Sharma, Chakrabhavi Gundurao Dileep. "Role of Inflammation and Angiogenesis in Aetiology of Bisphosphonate-related Osteonecrosis of the Jaws." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367505.
Full textAbstract:
Bisphosphonates (BPs) are a group of anti-resorptive agents that possess high binding affinity to bone mineral. They accumulate in bone and are released during bone turnover to inhibit resorption after their internalisation by osteoclasts. This has been described as the principal mechanism of action of BPs, warranting their use in various bone depleting conditions such as osteoporosis, Paget’s disease, metastatic bone diseases (breast cancer, prostate cancer and multiple myeloma primary sites) and paediatric osteogenesis imperfecta. However, BPs are associated with a significant adverse effect that selectively occurs in jaw bones, termed Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ). While the pathogenesis of BRONJ is not yet clearly understood, recent focus of research has been on their anti-angiogenic properties that could significantly contribute to the aetiopathogenic process by which the avascular necrosis of the jaw bone ensues. The focus of this project was to explore the mechanism by which the anti-angiogenic properties of BPs can lead to the occurrence of BRONJ lesions and subsequently formulate a localised approach for prevention of this painful and debilitating condition.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Dentistry and Oral health
Griffith Health
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Venkatesh, Lakshmi. "Speech movement characteristics of repetitive syllable production in children with speech disorders of unknown origin /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8264.
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Mello, Patrícia Bicalho de. "Estabilidade esquelética da multisegmentação maxilar /." Araraquara, 2014. http://hdl.handle.net/11449/123837.
Full textAbstract:
Orientador: João Roberto GonçalvesBanca: Alexandre Fortes Drummond
Banca: Rita de Cássia Moura Carvalho Lauris
Banca: Luiz Gonzaga Gandini Junior
Banca: Ary dos Santos Pinto
Resumo: O objetivo desse estudo foi colaborar com o conhecimento atual sobre a estabilidade da multisegmentação maxilar que é controverso na literatura. Foram estudados aspectos relacionados à estabilidade esquelética, verificando-se possíveis relações da instabilidade com a amplitude dos movimentos cirúrgicos realizados, direção dos movimentos cirúrgicos realizados, tempo de acompanhamento e idade. TCFC digitalizadas antes e após cirurgia ortognática com osteotomia maxilar em forma de Y em 3 segmentos de 30 indivíduos em três momentos distintos foram analisadas (T1-pré-cirurgia; T2-pós-cirurgia imediata e T3- mínimo de 11 meses de acompanhamento). Os volumes tomográficos pré e póscirúrgicos foram superpostos, utilizando a base do crânio como referência para todos pacientes. Após a segmentação da maxila foi realizada a quantificação dos deslocamentos entre os modelos nos diferentes momentos por ICP (iterative closest point). Os valores médios dos deslocamentos e seus respectivos intervalos de confiança foram determinados por reamostragem não paramétrica; Man-Whitney para comparações duplas e Kruskal-Wallis para comparações múltiplas. Para as medidas de correlação, o coeficiente de correlação de Spearman foi calculado. Quanto maior a amplitude do deslocamento maior a instabilidade; a correlação da instabilidade com idade e tempo de acompanhamento foram muito pequenas...(Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The present study was undertaken to collaborate with up to date knowledge about the stability of maxillary multisegmentation that presents itself quite controversially in literature. Aspects related to skeletal stability were studied verifying the possible involvement of instability with the extent and direction of surgical movements performed and age. CBCT scanned before and after orthognathic surgery with maxillary osteotomy Y-shaped in 3 segments of 30 subjects at three different times were analyzed ( T1 - pre-surgery, T2 - immediate post operative and T3 - at least 11 months follow up) . Pre and postoperative CT volumes were superimposed using the base of the skull as a reference for all patients. After segmenting the maxilla, quantification of displacements between models at different moments was performed. The mean values of the desplacements and their respective confidence intervals were determined by nonparametric resampling; Man-Witney for double comparisons and Kruskal-Wallis for multiple comparisons. To measure the correlation, Spearman coefficient was calculated. As the displacement increase the instability increase; the correlation of instability with age and follow-up were very small.
Doutor
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Li, Kin-shing. "Relation of hypotension anaesthesia to blood loss during othrognathic [sic] surgery." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2232947X.
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Huang, Bor-Yuan. "The influence of an occlusal alteration on the working-side condylar movement and the activity of the jaw muscles during defined lateral jaw movements." Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/4837.
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Shiller, Douglas M. "Compensation for the gravitational force on the jaw during speech." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0003/MQ43949.pdf.
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Shiller, Douglas M. "Understanding speech motor control in the context of orofacial biomechanics." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84435.
Full textAbstract:
A series of experiments are described which explore the relationship between biomechanical properties and the control of jaw movement in speech. This relationship is documented using kinematic analyses in conjunction with a mathematical model of jaw motion and direct measures of jaw stiffness.In the first experiment, empirical and modeling studies were carried out to examine whether the nervous system compensates for naturally occurring forces acting on the jaw during speech. As subjects walk or run, loads to the jaw vary with the direction and magnitude of head acceleration. While these loads are large enough to produce a measurable effect on jaw kinematics, variation in jaw position during locomotion is shown to be substantially reduced when locomotion is combined with speech. This reduction in jaw motion is consistent with the idea that in speech, the control of jaw movement is adjusted to offset the effects of head acceleration. Results of simulation studies using a physiologically realistic model of the jaw provide further evidence that subjects compensate for the effects of self-generated loads by adjusting neural control signals.
A second experiment explores the idea that a principle mechanical property of the jaw---its spring-like behavior, or stiffness---might influence patterns of kinematic variation in speech movements. A robotic device was used to deliver mechanical perturbations to the jaw in order to quantify stiffness in the mid-sagittal plane. The observed stiffness patterns were non-uniform, with higher stiffness in the protrusion-retraction direction. Consistent with the idea that kinematic patterns reflect directional asymmetries in stiffness, a detailed relationship between jaw kinematic variability and stiffness was observed---kinematic variability was consistently higher under conditions in which jaw stiffness was low. Modeling studies suggested that the pattern of jaw stiffness is significantly determined by jaw geometrical properties and muscle force generating abilities.
A third experiment examines the extent to which subjects are able to alter the three-dimensional pattern of jaw stiffness in a task-dependent manner. Destabilizing loads were applied to the jaw in order to disrupt the ability of subjects to maintain a static jaw posture. Subjects adapted by increasing jaw stiffness in a manner that depended on the magnitude and, to a more limited extent, direction of the destabilizing load. The results support the idea that stiffness properties can be controlled in the jaw, and thus may play a role in regulating mechanical interactions in the orofacial system.
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Li, Kin-shing, and 李健誠. "Relation of hypotension anaesthesia to blood loss duringothrognathic [sic] surgery." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31954121.
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Brozoski, Mariana Aparecida. "Efeito de diferentes concentrações do alendronato sódico sobre a viabilidade e proliferação de diferentes tipos celulares em cultura." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/23/23149/tde-20092011-162508/.
Full textAbstract:
Os bisfosfonatos têm sido indicados para o tratamento de doenças ósseas líticas. Atualmente, seu emprego terapêutico aumentou e com ele os efeitos adversos, sendo um dos mais importante a indução da osteonecrose dos maxilares, uma complicação de difícil tratamento e solução. Até o presente, não se sabe ao certo qual o mecanismo de desenvolvimento da osteonecrose e nem qual deve ser o melhor tratamento estabelecido perante essa manifestação. Este trabalho teve como objetivo avaliar o efeito do alendronato sódico sobre a viabilidade e proliferação de osteoblastos e fibroblastos em cultura. Foram utilizados osteoblastos-símile linhagem OSTEO 1 e fibroblastos de mucosa bucal humana linhagem FMM1. Após serem submetidos aos testes de citotoxicidade com concentrações do alendronato sódico variando de 10-2M a 10-8M os fibroblastos apresentaram diminuição significante de viabilidade celular apenas na concentração de 10-2M (p<0,01). Os osteoblastos demonstraram viabilidade celular no grupo controle significantemente maior que todos os demais grupos; o grupo tratado com o alendronato na concentração de 10-4M apresentou viabilidade celular semelhante a de todos os grupos, exceto o grupo de concentração 10-2M e a viabilidade celular dos demais grupos foi semelhante entre si (p<0,01). As concentrações de alendronato sódico superiores a 10-5M impediram a proliferação dos osteoblastos. Foi possível concluir que o alendronato sódico é citotóxico para células osteoblastos-símile e fibroblastos em cultura em função de sua concentração. Os fibroblastos são menos sensíveis a concentrações maiores de alendronato sódico que os osteoblastos.Bisphosphonates have been therapeutically used for the management of lytic bone diseases. Their use has been increased nowadays and besides that associated adverse effects have been amplified. Jaw osteonecrosis induced by this drug is perhaps the most important complication because of the great morbidity and difficulty to deal with. Until now the physiopathology of osteonecrosis remains unclear and the treatment that should be established is uncertain. This study aimed to evaluate the effect of sodium alendronate a bisphosphonate used for the treatment of osteoporosis on the viability and proliferation of osteoblasts and fibroblasts in culture. Osteoblast-simile from the lineage OSTEO1 and a human oral mucosa fibroblasts from the lineage FMM1 were used. After being subjected to tests with concentrations of sodic alendronate ranging from 10-8M to 10-2M fibroblasts showed a significant decrease in cell viability at the concentration of 10-2M (p < 0.01). Osteoblasts showed that the cell viability in the control group was significantly higher than all other groups, the group treated with alendronate at a concentration of 10-4M had similar cell viability with all groups except the group of 10-2M concentration and the cell viability of other groups was similar between groups (p < 0.01). The concentrations of alendronate greater than 10-5M prevented the proliferation of osteoblasts. It was possible to conclude that alendronate is cytotoxic to osteoblast-símile cells and fibroblasts in culture due to its concentration. The fibroblasts are less sensitive to higher concentrations of alendronate than osteoblasts.
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McGowan, Kelly. "Risk factors for medication-related osteonecrosis of the jaws: a case-control study in Queensland, Australia." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/385549.
Full textAbstract:
BACKGROUND
Medication-related osteonecrosis of the jaws (MRONJ) is a serious condition that
develops in up to 15% of patients who take antiresorptive or antiangiogenic medications.
Despite extensive research into MRONJ since it was first reported in 2003, it is not clear
why a minority of patients will develop this complication, and no gold standard treatment
currently exists. A number of possible risk factors for MRONJ have been reported, but
the existing evidence is weak and often contradictory. Preventative dentistry has been
shown to reduce the incidence of MRONJ, but current guidelines are based on expert
opinion and clinical experience. There is a need to better understand the factors that
predispose a patient to MRONJ, and define the role of preventative dental care in reducing
the incidence of this disease.
AIMS
The purpose of this research was to investigate the contributing risk factors for
MRONJ and identify targets and strategies for MRONJ prevention. The intention was to
develop an evidence-base for the dental management of patients taking antiresorptive and antiangiogenic medications.
METHODS
The first stage of this project was to conduct a systematic review of patient
populations susceptible to MRONJ and previously reported risk factors. These data were
used to define three risk categories for further investigation: dental risk factors, systemic
risk factors, and haematological abnormalities as putative risk markers. A survey of
patients treated at Royal Brisbane and Women’s Hospital (RBWH) and Gold Coast
University Hospital (GCUH) between January 2003 and March 2017 was conducted to
identify eligible cases of MRONJ and to determine whether the number of cases had
changed over time with increasing awareness and understanding of MRONJ. Three casecontrol
studies were used to compare the presence or absence of dental and systemic risk
factors and haematological abnormalities between patients with a clinical diagnosis of
MRONJ and disease-free controls. Three controls were individually matched to each case according to sex, age, primary disease, and antiresorptive type, dose, and duration.
Associations between risk factors and MRONJ were investigated using conditional
logistic regression.
FINDINGS
The systematic review identified 4106 cases of MRONJ, which included patients
being treated for 39 different systemic diseases. There was very low level evidence for
25 possible dental and systemic disease indicators, and haematological risk markers. A
clear need for more research into risk factors for MRONJ was identified.
Since the first case of MRONJ was reported in 2003, the number of patients
diagnosed with MRONJ at RBWH and GCUH has steadily increased. This suggests that
improved awareness of MRONJ and the importance of preventative dental care has not
translated into a reduction in disease. A number of comorbidities were found to be
significant risk factors for MRONJ, including diabetes, cardiovascular disease, kidney
disease, and tobacco use. The Comorbidity Polypharmacy Score (CPS) was determined
to be a valid measure of MRONJ risk, and provides clinicians with a simple method of
quantifying the cumulative severity of systemic risk factors.
Two-thirds of all patients did not receive a dental examination in the 12 months
prior to starting antiresorptives, and participants averaged less than one dental exam every
three years during antiresorptive therapy. Cases averaged approximately one extraction
and one filling per year during their antiresorptive therapy, which was significantly higher
than treatment rates in the control group. Dental extractions and non-surgical dental care
(fillings and dentures) increased the risk of MRONJ eight and six times, respectively.
Cases who developed MRONJ and disease-free controls reported blood test results outside of laboratory reference ranges in similar frequencies. The most commonly
reported abnormal results were low haemoglobin, low haematocrit, and low lymphocyte
counts. The results of a full blood count do not appear to relate to the risk of MRONJ, but
this does not preclude the role of immune function in the development of MRONJ.
MRONJ appears to be a complex multifactorial disease. The underlying
pathogenesis remains unclear, but there appears to be a significant opportunity to reduce
the incidence of MRONJ by improving access to dental care before starting, and during,
antiresorptive therapy. This will require a coordinated and collaborative approach from
patients, doctors, and oral health professionals.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Dentistry&Oral Hlth
Griffith Health
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Laparidis, Con. "A retrospective cephalometric study of the effect of the Fränkel appliance, the ClarkTwin Block and the activator on class II division /." Title page, contents and summary only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phl299.pdf.
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Abreu, Marcos Petto Nunes de. "Avaliação do uso da ultrassonografia modo B para exploração através de tecido ósseo de costelas bovinas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-14012013-153719/.
Full textAbstract:
O uso da ultrassonografia, para diagnóstico, como forma de exame complementar na área da Saúde é cotidiano e consagrado, principalmente no estudo e avaliação das doenças em tecidos moles. Com a consolidação e o desenvolvimento deste método, novos usos vem sendo descritos. Existem relatos científicos da possibilidade do uso do ultrassom para avaliação de lesões no interior do tecido ósseo. Frente a esta alternativa, o presente estudo avaliou o uso da ultrassonografia para exploração através de tecido ósseo, de diferentes espessuras, com a utilização de um modelo laboratorial em costelas bovinas, definindo a espessura óssea cortical que permite a passagem do ultrassom. Primeiramente realizamos um ensaio experimental para definir a melhor metodologia para o estudo. O modelo laboratorial usado era constituído por uma costela bovina, macerada, desgastada em diferentes espessuras. A amostra do estudo foi constituída em 180 leituras de ultrassom provenientes de 20 costelas bovinas maceradas; onde cada uma delas foi examinada em 9 áreas que se diferenciavam na espessura do remanescente ósseo; assim definidas 4,0mm, 3,0mm, 2,5mm, 2,0mm, 1,5mm, 1,0mm, 0,5mm, 0,2mm e sem desgaste. Para os exames de ultrassom foi utilizado o aparelho de ultrassom portátil Terason t3000 (Terason, divisão da Teratech Corporation, USA). Os exames foram realizados pela técnica da imersão, onde se mergulhava os espécimes e o transdutor do ultrassom em um recipiente com água. Para avaliar se havia ou não passagem da onda de ultrassom pelo tecido ósseo, em uma determinada espessura, era observada a formação de imagem de um objeto metálico posicionado atrás do osso. Conforme observado pela tabulação dos resultados ocorreu a passagem das ondas de ultrassom através do osso de espessuras 2,0mm, 1,5mm, 1,0mm, 0,5mm e 0,2mm diferentemente do ocorrido nas espessuras 4,0mm, 3,0mm, 2,5mm e sem desgaste. Houve diferença estatisticamente significante (P<0,001) entre as espessuras menores ou iguais a 2,0mm e as espessuras maiores ou iguais a 2,5mm, quanto a formação de imagem ultrassonográfica de um objeto metálico posicionado atrás do tecido ósseo. Concluímos que houve possibilidade de utilização do exame de ultrassom na avaliação através do tecido ósseo de espessuras menores ou iguais a 2,0mm.The use of ultrasound as a complementary examination in health diagnoses is something usual and well established, mainly in the study and evaluation of diseases in soft tissue. As the consolidation and development of this method ocourred, new uses for it has been described. There are scientific reports with the possibility of the use of ultrasound for the evaluation of lesions within the bone tissue. Faced with this alternative, the aim of the present study was to evaluate the use of ultrasound for exploration through the bone tissue of different thicknesses, using a laboratory model of beef ribs, so thath would be defined the minimum required thicknesses of cortical bone for passage of the ultrasound. First we conducted an experimental trial to determine the best methodology for the study. The laboratory model used consisted of beef ribs prepared in different thicknesses. The study sample consisted of 180 ultrasound readings from 20 macerated beef ribs, each of which was examined in 9 different areas defined as, no wear, 4.0 mm, 3.0 mm, 2.5 mm, 2.0 mm, 1.5mm, 1.0mm, 0.5mm and 0.2mm in thicknesses of the remaining bone. For ultrasound scanning was used a portable ultrasound device, Terason t3000 (Terason, a division of Teratech Corporation, USA). The examinations were performed by the technique of immersion, where the specimens and the ultrasound transductor were immersed in a water tank. To assess whether there was passage of ultrasound waves by the bone tissue in a certain thickness, it was observed the occurrence of a image formation from a metallic object that was positioned behind the bone. As noted by tabulating the results, there was passage of ultrasound waves through the bone thickness 2.0mm, 1.5mm, 1.0mm, 0.5mm and 0.2mm different from those occurred in thickness of 4.0mm, 3.0mm, 2.5mm and no wear. There was significant difference (P<0.001) between the thicknesses less than or equal to 2.0 mm and thickness greater than or equal to 2.5 mm, in the ultrasound imaging of a metallic object positioned behind the bone. We conclude that there was possibility of using the ultrasound examination in the evaluation through the bone thickness less than or equal to 2.0mm.
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Santosa, Robert. "The influence of the leaf gauge on jaw muscles, EMG." Master's thesis, Faculty of Dentistry, 2001. http://hdl.handle.net/2123/4838.
Full textAbstract:
This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au
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Bambuliak, A. V., Y. V. Gorytskyi, and R. R. Dmytrenko. "Features of complex treatment of chronic osteomyelitis of jaws in narcotic dependent patients in Chernivtsi and Chernivtsi region." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17310.
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Strong, Edward Trowbridge. ""The Jaws of Mars are Traditionally Wide ... And His Appetite Is Insatiable": Truman, the Budget, and National Security." Miami University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=miami1564568978026948.
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ALBANESE, Antonino. "THE COMBINED USE OF PRP AND ER,CR: YSGG LASER IN THE TREATMENT OF OSTEONECROSIS OF THE JAWS." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91332.
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FARO, A. F. F. LO. "ZOLENDRONATE E ALENDRONATE DOSING IN BONE SEQUESTRA FROM BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAWS: A MULTICENTER OBSERVATIONAL STUDY." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/534300.
Full textAbstract:
Bisphosphonates (BP), syntetic analogues of inorganic pyrophosphate are able to inhibit the osteoclastic activity, quickly bonding the mineral component of bone structure. BPs are excreted unchanged by glomerul filtration in urine, except for a very small fraction, which is excreted in the bile. After they are absorbed by the bone, BPs are released from hydroxyapatite during bone resorption, taken-up by osteoclasts, and then they are released again when the bone is resorbed. This explain the very slow and long elimination of all BPs from skeleton [ Drake MT et al., 2010]. Consequently, a long time accumulation in the osseous tissue has benn speculated. Nevertheless, a direct method to measure these drugs in the human bone tissue is not available in literature. In man, the concentration of BPs stored in bone is estimated on basis of administred dose and quantity of drugs detected in serum and, most of all, in urine. Considering the complete absence of information on this topic, the aim of this study is to investigate the presence of BPs in bone sequestra (surgically removed or naturally exfoliated) in patients with osteonecrosis of the jaw caused byBPs (BRONJ), followed by the Oral Pathology Unit of the San Paolo Hospital, University of Milan, and in Dental Unit of Papa Giovanni Paolo XXIII Hospital of Bergamo.
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Lau, Sze-lok Alfred. "Evidence-based practice in oral and maxillofacial surgery /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B32222154.
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