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Journal articles on the topic 'IVF'

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Published: 4 June 2021

Last updated: 7 July 2024

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1

Miles, Harriet L., Paul L. Hofman, John Peek, Mark Harris, Dyanne Wilson, Elizabeth M. Robinson, Peter D. Gluckman, and Wayne S. Cutfield. "In Vitro Fertilization Improves Childhood Growth and Metabolism." Journal of Clinical Endocrinology & Metabolism 92, no. 9 (September 1, 2007): 3441–45. http://dx.doi.org/10.1210/jc.2006-2465.

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Abstract Background: There is limited information regarding the long-term outcome of children born after in vitro fertilization (IVF), although an increase in rare imprinted gene disorders such as Beckwith-Wiedemann syndrome has been reported. Methods: We recruited healthy, prepubertal children born at term after singleton pregnancy. The children in the study group were conceived using IVF with fresh embryo transfer, whereas controls were naturally conceived. Anthropometric measurements, bone age, dual-energy x-ray absorptiometry, fasting serum glucose, insulin, lipid profile, IGF-I and -II, and IGF-binding proteins 1, 2, and 3 were performed. Results: There were 69 IVF children aged 5.9 ± 0.2 yr and 71 control children aged 6.9 yr. IVF children were taller than controls when corrected for parents’ heights (height sd score of 1.05 ± 0.1 vs. 0.51 ± 0.11, P = 0.001) with higher levels of serum IGF-II (850 ± 24 vs. 773 ± 24 μg/liter, P = 0.03), higher IGF-I to IGF-binding protein 3 ratio (P = 0.04), and a trend toward higher IGF-I (105 ± 4 vs. 92 ± 4 μg/liter, P = 0.06). IVF children had higher high-density lipoprotein (1.67 ± 0.04 mmol/liter vs. 1.53 ± 0.04 mmol/liter, P = 0.02), lower triglycerides (0.65 ± 0.04 mmol/liter vs. 0.78 ± 0.04 mmol/liter, P = 0.02), and a lower total to high-density lipoprotein cholesterol ratio (2.58 vs. 2.86, P = 0.01). There were no differences in body composition. Conclusions: IVF children are taller with higher IGF-I and IGF-II levels and have a slightly more favorable lipid profile. We speculate that IVF results in epigenetic change through altered methylation of genes involved in growth and metabolism. IVF programs should consider long-term longitudinal follow-up of IVF offspring.

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2

Kim, S., S. H. Lee, J. H. Kim, Y. W. Jeong, O. J. Koo, S. Mi Park, E. G. Lee, et al. "46 ANTI-APOPTOTIC EFFECT OF INSULIN-LIKE GROWTH FACTOR-1 AND ITS RECEPTOR ON DEVELOPMENT OF PORCINE PRE-IMPLANTATION EMBRYOS PRODUCED BY IN VITRO FERTILIZATION AND SOMATIC CELL NUCLEAR TRANSFER." Reproduction, Fertility and Development 18, no. 2 (2006): 132. http://dx.doi.org/10.1071/rdv18n2ab46.

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Insulin-like growth factor (IGF)-I is a receptor-mediated autocrine and/or paracrine growth and/or survival factor for mammalian embryo development. It is known to promote the growth and development of mouse pre-implantation embryos. The present study was designed to investigate the effects of IGF-I (50 ng/mL), anti-IGF-I receptor (IGR-IR) antibody (0.05 �g/mL), and their combination on porcine pre-implantation embryo development. Furthermore, the mechanism underlying the embryotropic effects of IGF-I was evaluated by monitoring the incidence of apoptosis and expression of apoptosis-related genes. In both IVF and SCNT embryos, culturing with IGF-I increased the rate of blastocyst formation and this embryotropic effect was neutralized by culturing with IGF-I and anti-IGF-I receptor antibody. Significant effects on the development of blastocysts (P < 0.05) were found in IVF (16.9, 22.6, 9.3, and 13.5% for control, IGF-I, anti-IGF-IR antibody, and their combination, respectively) and SCNT (13.2, 21.0, 5.4, and 15.7%) embryos. Culturing IVF and SCNT embryos with IGF-I significantly increased the total number of cells in IVF blastocysts (58.3, 72.4, 41.1, and 55.2; P < 0.05), and SCNT blastocysts (49.2, 60.1, 35.2, and 43.1; P < 0.05), and it decreased the number of apoptotic nuclei in IVF blastocysts (3.9, 2.8, 5.5, and 3.9; P < 0.05) and SCNT blastocysts (4.6, 3.0, 6.1, and 4.9; P < 0.05). These effects of IGF-I were also neutralized by culturing with IGF-I along with anti-IGF-IR antibody. Expression of the anti-apoptotic Bcl-2 gene was increased, whereas expression of the pro-apoptotic Bax gene was decreased in both IVF and SCNT embryos cultured with IGF-I. In both IVF and SCNT embryos, anti-IGF-IR antibody along with IGF-I neutralized the effect of IGF-I on expression of Bcl-2 and Bax genes. In conclusion, the present study demonstrated that IGF-I through its specific receptors improved the developmental competence of IVF and SCNT embryos by decreasing the incidence of apoptosis and regulating apoptosis-related genes in porcine pre-implantation embryos. This study was supported by grants from the Korean MOST (Top Scientist Fellowship) and MAF (Biogreen 21 #20050301-034-443-026-01-00).

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3

O'Neill, C., and T. Stojanov. "240.Fertilisation in vitro causes precocious activation of transcription from the zygotic genome." Reproduction, Fertility and Development 16, no. 9 (2004): 240. http://dx.doi.org/10.1071/srb04abs240.

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In vitro fertilisation (IVF) may have long-term adverse effects on progeny. Infants conceived by in vitro fertilisation are more likely to be born small for dates and, in a mouse model, culture in vitro caused changes in neurological performance of progeny. Changes in the pattern of gene expression in IVF embryos have been detected, and these may be one cause of the long-term effects. This study investigates the effect of IVF on the ontogeny of onset of expression from the embryonic genome in the mouse. The expression of two markers for the onset of transcription (the transcription requiring complex (TRC) and hsp 70.1) was assessed in 2-cell embryos produced by IVF or fertilisation in situ (ISF). It was confirmed that the time from fertilisation to first cleavage was not different for IVF and ISF. Zygotes were cultured and at 1-hourly intervals those cleaved were 'picked off' (time 0 h after cleavage) and placed in groups of 10 in 10 μL of modified-HTF. The expression of the gene products was assayed at times after 'pick-off'. The proportion of embryos expressing TRC increased with time after cleavage (P�<�0.001). IVF embryos expressed it significantly earlier (P�<�0.01) than ISF embryos. Some IVF embryos expressed TRC immediately after cleavage and this was never found for ISF embryos. All IVF embryos were TRC-positive by 2.5 h after cleavage, while this did not occur until 4.5 h post cleavage for ISF. Hsp70.1 transcripts were first detected in IVF embryos 2 h after cleavage but not until 6 h after cleavage in ISF embryos (P�<�0.01). The onset of transcription at the 2-cell stage is currently thought to reflect major reorganization of the nucleosomal structure of DNA. Evidence for precocious onset of transcription may indicate that this fundamentally import process is changed following IVF, and warrants further investigation.

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4

Gleicher, Norbert, Sarah K. Darmon, Emanuela Molinari, Pasquale Patrizio, and David H. Barad. "Importance of IGF-I levels in IVF: potential relevance for growth hormone (GH) supplementation." Journal of Assisted Reproduction and Genetics 39, no. 2 (January 23, 2022): 409–16. http://dx.doi.org/10.1007/s10815-021-02379-8.

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Abstract Purpose Growth hormone (GH) supplementation in association with in vitro fertilization (IVF) is worldwide again increasing, even though study outcomes have been discrepant. Since GH acts via insulin-like growth factor-1 (IGF-1), its utilization in IVF would only seem to make sense with low IGF-1. We, therefore, determined whether IGF-I levels affect IVF outcomes. Methods Retrospectively, 302 consecutive first fresh, non-donor IVF cycles were studied, excluding patients on GH supplementation. Patients were divided into 3 subgroups: IGF-1 in lower 25th percentile (group A, < 132 ng/mL, n = 64); 25th–75th percentile (B, 133–202 ng/mL, n = 164), and upper 25th percentile (C, > 202 ng/mL, n = 74). IGF-1 was tested immunochemiluminometric with normal range at 78–270 ng/mL. Because of the study patients’ adverse selection and low pregnancy chances, the main outcome measure for the study was cycle cancellation. Secondary outcomes were oocyte numbers, embryos transferred, pregnancies, and live births. Results Group A was significantly older than B and C (P = 0.019). IGF-1 decreased with increasing age per year by 2.2 ± 0.65 ng/mL (P = 0.0007). FSH was best in group B and worst in A (trend, P = 0.085); AMH was best in B and worst in A (N.S.). Cycle cancellations were lowest in C (11.6%) and highest in A (25.0%; P = 0.042). This significance further improved with age adjustment (P = 0.021). Oocytes, embryo numbers, pregnancies, and live birth rates did not differ, though oocyte numbers trended highest in B. Conclusions Here presented results support the hypothesis that IGF-1 levels affect IVF outcomes. GH treatments, therefore, may be effective only with low IGF-1.

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5

Gagel, D. E., D. Ulrich, V. S. Pastor, and H. Kentenich. "IVF-Paare und IVF-Kinder." Reproduktionsmedizin 14, no. 1 (May 5, 1998): 31–40. http://dx.doi.org/10.1007/s004440050020.

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6

Malyugin, B. E., E. N. Panteleev, A. N. Bessarabov, D. F. Pokrovskiy, A. S. Semakina, and S. A. Abdullaeva. "Comparative Analysis of Refractive Result Predictability During Iridocapsular and Iridovitreal Fixation of Biplanar Intraocular Lens." Ophthalmology in Russia 15, no. 2 (July 5, 2018): 139–45. http://dx.doi.org/10.18008/1816-5095-2018-2-139-145.

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Purpose: to carry out a comparative analysis of refractive outcomes and features during preoperational calculation of the biplanar intraocular lens (IOL) with iridocapsular and iridovitreal fixation.Patients and methods. Study included the analysis IOL model RSP-3 implantation after phacoemulsification cataract surgery with subluxated lens grade 2. Analyzed 309 eyes of 304 patients with iridocapsular (n = 44) (ICF) and iridovitreal fixation (n = 265) (IVF). In both groups IOL power was calculated with use of A- constant (118.2) recommended by manufacturer. Mean period of examination was 6 months. To count optimized A-constant in both groups we used next data: IOL power and axial length before surgery, keratometry, spherical equivalent and IOL effective position during 6 months after surgery.Results. In group with ICF postoperative refraction was achieved ± 0,5 D in 10 cases (23%), in group IVF — in 29 cases (11%). Mean value of optimized A-constant for IOL model RSP-3 in groups with ICF and IVF were 117.2 ± 1.18 (114.0–120.8) and 116.9 ± 1,89 (109.6 до 123.6). There were no statistically significant difference between compared groups (p = 0.46).Conclusion. Use of A-constant recommended by manufacturer do not allow achieving target refraction in most cases. Mean values of biplanar IOL A-constant counted for ICF and IVF were 117,2 and 116,9 respectively, what should be taken into account during IOL power count, according to its fixation method.

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7

Lu, F., T. Luo, H. Sun, N. Li, X. Liu, L. Meng, J. Jiang, and D. Shi. "136 EFFECTS OF INSULIN-LIKE GROWTH FACTOR I (IGF-1) ON THE DEVELOPMENT AND APOPTOSIS OF PREIMPLANTATION BUFFALO (BUBALUS BUBALIS) EMBRYOS." Reproduction, Fertility and Development 25, no. 1 (2013): 215. http://dx.doi.org/10.1071/rdv25n1ab136.

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The aim of this study was to explore the effects of insulin-like growth factor-I (IGF-1) on the development and apoptosis of preimplantation buffalo (Bubalus bubalis) embryos derived from IVF or somatic cell nuclear transfer (SCNT) in order to improve the quality of in vitro embryo culture (IVC). Buffalo oocytes collected from ovaries at slaughter were cultured in the maturation medium (TCM-199 + 26.2 mmol L–1 NaHCO3 + 5 mmol L–1 HEPES + 5% FBS) for 22–24 h, and fertilized in vitro, or enucleated and reconstructed for SCNT. Embryos were then cultured in the culture medium (CM: TCM-199 + 3% FBS) supplemented with different concentrations of IGF-1. Blastocyst development was evaluated after 7 days of culture. A total of 1566 oocytes were used in this study. The experimental data were analyzed using two-way ANOVA, P < 0.05 was considered to be statistically significant. The results showed that the cleavage rates of IVF or SCNT embryos cultured with 0, 10, 50, or 100 ng mL–1 IGF-I, were not significantly different (P > 0.05). However, the blastocyst rate of IVF embryos cultured with 50 ng mL–1 IGF-1 was significantly increased compared to the 0 ng mL–1 group (35.1 v. 23.0%; P < 0.05), but not significantly different among the 0, 10, and 100 ng mL–1 groups (23.0 v. 28.2 and 26.5%; P > 0.05). In the same line, more SCNT embryos could develop to the blastocyst stage when cultured in the CM supplemented with 50 ng mL–1 IGF-I by comparison with the 0 ng mL–1 group (32.3 v. 20.2%; P < 0.05), but the blastocyst development decreased with 100 ng mL–1 (32.3 v. 21.4%; P < 0.05). Apoptosis and total cell number (TCN) of IVF/SCNT blastocysts were respectively detected by TUNEL or Hoechst 33342 staining. By comparison with the 0 ng mL–1 group, the TCN of IVF/SCNT blastocysts was significantly increased (IVF: 91.7 ± 6.9 v. 108.7 ± 3.9, SCNT: 76.3 ± 5.6 v. 92.8 ± 3.9; P < 0.05) and the apoptotic index was obviously decreased (IVF: 3.9 ± 0.7 v. 2.5 ± 0.7; 7.2 ± 0.5 v. 2.9 ± 0.5; P < 0.05) when the embryos were cultured in the CM with 50 ng mL–1 IGF-I. The result of RT-qPCR analysis showed that the mRNA expression level of the anti-apoptotic bcl-2 gene was distinctly enhanced, while the mRNA expression level of the pro-apoptotic bax gene was remarkably reduced in IVF/SCNT embryos cultured with 50 ng mL–1 IGF-I by comparison with the 0 ng mL–1 group (P < 0.05). These results demonstrated that supplementing CM with 50 ng mL–1 IGF-1 could improve the developmental competence of buffalo embryos, increase the TCN of blastocysts and decrease their apoptotic index, probably by down-regulating the mRNA level of pro-apoptotic bax gene and up-regulating the mRNA level of anti-apoptotic bcl-2 gene. This work was funded by the China High Technology Development Program (2011AA100607), China Natural Science Foundation (31072033), and Guangxi Science Foundation (2012GXNSFFA060004).

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8

Cela, Vito, Simona Daniele, Maria Elena Rosa Obino, Maria Ruggiero, Elisa Zappelli, Lorenzo Ceccarelli, Francesca Papini, et al. "Endometrial Dysbiosis Is Related to Inflammatory Factors in Women with Repeated Implantation Failure: A Pilot Study." Journal of Clinical Medicine 11, no. 9 (April 28, 2022): 2481. http://dx.doi.org/10.3390/jcm11092481.

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An abnormal endometrial microbiota has been suggested to impair the process of embryo implantation, thus leading to repeated implantation failure (RIF) in women undergoing in vitro fertilization (IVF). However, the molecular mechanisms linking uterine microbiota and IVF out-comes are still an open question. The aim of this cohort study was to outline the relationship between endometrial microbiota, inflammation and IVF outcomes. To this purpose, endometrial microbiota and selected components of the “cytokine network” were analyzed in women presenting RIF and divided between eubiosis and dysbiosis groups, according to the percentage of endometrial lactobacilli (≥90% or <90%, respectively). The Dysbiosis group presented significantly higher tissue concentrations of the inflammatory markers (IL-6, IL-1β, HIF-1α and COX-2) and significantly lower levels of the anti-inflammatory/well-being factors, IL-10 and IGF-1, with respect to women with eubiosis. Moreover, the Lactobacillus percentage was negatively related to the concentrations of the inflammatory molecules and positively related to IL-10/IGF-1. Interestingly, the number of IVF attempts was directly related to the levels of the inflammatory factors COX-2, IL-1β and HIF-1α in the eubiosis group. Overall, endometrial dysbiosis was demonstrated to be associated with inflammation-related endometrial changes affecting the process of embryo implantation, underlining the importance of assessing uterine microbiota in patients undergoing IVF.

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9

Garcia Velasco, Juan Antonio, and Emre Seli. "IVF." Current Opinion in Obstetrics and Gynecology 27, no. 3 (June 2015): 165–66. http://dx.doi.org/10.1097/gco.0000000000000178.

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10

Seli, Emre, and Juan Garcia-Velasco. "IVF." Current Opinion in Obstetrics and Gynecology 28, no. 3 (June 2016): 149–50. http://dx.doi.org/10.1097/gco.0000000000000275.

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11

Templeton, Allan. "IVF." International Journal of Gynecology & Obstetrics 70 (2000): B15. http://dx.doi.org/10.1016/s0020-7292(00)86123-8.

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12

Zhang, John J., Zaher Merhi, Mingxue Yang, Daniel Bodri, Alejandro Chavez-Badiola, Sjoerd Repping, and Madelon van Wely. "Minimal Stimulation IVF vs Conventional IVF." Obstetrical & Gynecological Survey 71, no. 4 (April 2016): 228–29. http://dx.doi.org/10.1097/01.ogx.0000481797.88347.f9.

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13

Mau Kai, Claudia, Katharina M. Main, Anders Nyboe Andersen, Anne Loft, Marla Chellakooty, Niels E. Skakkebæk, and Anders Juul. "Serum Insulin-Like Growth Factor-I (IGF-I) and Growth in Children Born after Assisted Reproduction." Journal of Clinical Endocrinology & Metabolism 91, no. 11 (November 1, 2006): 4352–60. http://dx.doi.org/10.1210/jc.2006-0701.

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Abstract Context: Concern has been raised about the safety of assisted reproduction techniques for the offspring. Objectives: The objective of the study was to investigate postnatal growth and growth factors in children born after intra-cytoplasmatic sperm injection (ICSI) and in vitro fertilization (IVF). Design: The study had two cohorts: a population-based longitudinal infant cohort 0–36 months [236 ICSI, 173 IVF, 1530 naturally conceived (NC)], and a cross-sectional child cohort at 5 yr (68 ICSI, 67 IVF, 70 NC). Intervention: Anthropometrical measurements were made at birth, 3, 18, 36 (infant cohort), and 60 months (child cohort), and blood samples were collected at 3 or 60 months. Main Outcome Measures: Serum IGF-I, IGFBP-3, height, weight, head and abdominal circumference, body mass index, and fat folds were the main outcome measures. Results: Anthropometrical measurements showed no significant differences between ICSI and IVF children and controls in either cohort. However, singleton ICSI girls [3.4 (0.6) kg, P = 0.008] had a slightly lower birth weight than IVF [3.5 (0.5) kg] and NC girls [3.5 (0.5) kg]. Birth weights of singleton boys [3.6 (0.5) kg], twin boys [2.6 (0.6) kg], and twin girls [2.4 (0.5) kg] did not differ between types of conception. In the infant cohort in 3-month-old singletons, serum IGF-I was lower in ICSI [78 (26) ng/ml] than NC boys [94 (27) ng/ml, P < 0.001] and IVF [74 (34) ng/ml], compared with NC girls [93 (43) ng/ml, P = 0.011]. ICSI children were also smaller than their target height (sd score) at 3 yr of age [mean −0.91 (1.2)], compared with NC children [−0.61 (0.9), P = 0.033]. In the child cohort, target height attainment (sd score) and growth factors did not differ among the three groups. Conclusions: The overall growth pattern of ICSI and IVF children in both cohorts was normal. Our findings of subtle differences in target height attainment and serum IGF-I levels between infants born after assisted reproduction techniques and controls may not be clinically significant. However, these observations indicate that further systematic follow-up of growth and puberty in these children is needed.

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14

Edwards, RG. "IVF, IVM, natural cycle IVF, minimal stimulation IVF – time for a rethink." Reproductive BioMedicine Online 15, no. 1 (January 2007): 106–19. http://dx.doi.org/10.1016/s1472-6483(10)60699-2.

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15

Zhang, J., A. Chavez-Badiola, W. Peng, L. Chang, and L. A. Ruvalcaba-Castellon. "Soft ovarian stimulation IVF (Mini–IVF) vs conventional IVF: an economic perspective." Fertility and Sterility 90 (September 2008): S213. http://dx.doi.org/10.1016/j.fertnstert.2008.07.508.

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John L Yovich, Syeda Zaidi, Minh DK Nguyen, and Peter M Hinchliffe. "Measuring IGF-1 and IGFBP-3 profiles in women seeking assisted reproduction; relevance to clinical outcomes from in vitro fertilization (Study 5)." GSC Biological and Pharmaceutical Sciences 13, no. 3 (December 30, 2020): 079–96. http://dx.doi.org/10.30574/gscbps.2020.13.3.0355.

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In this fifth study examining the relevance of the insulin-like growth factor (IGF) profiles, namely serum IGF-1 levels, its main binding protein, serum IGFBP-3 levels and the IGF ratio (IGFBP-3/IGF-1), we have examined clinical outcomes with respect to the quartile ranges of each parameter measured in 1633 IVF-naïve women. The outcomes were derived from 1035 of these women who initiated 1747 IVF cycles. Of the three parameters, only IGF-1 levels proved relevant to the clinical outcomes. In particular, this study confirmed our earlier report that IGF-1 levels decline across the quartiles with the woman’s advancing age and the proportion of women with IGF-1 levels in the highest quartile comprised the younger, whilst those women ≥40 years were mostly in the lowest quartile (p<0.0001). IVF cycle cancellations were not different across the quartiles but at oocyte pick-up (OPU) there were significantly more oocytes from the highest IGF-1 quartile (10.4 oocytes) compared to the lowest (8.9 oocytes; p<0.01). Furthermore, the proportion of oocytes shown to be at the mature MII stage were also significantly higher (p=0.01). Consequently, the oocyte utilization rate was significantly greater from those women with the highest IGF-1 levels generating 5.3 embryos vs 4.3 embryos for the lowest quartile. However, the utilization rate of those embryos generated were similar across the IGF-1 quartiles and there were similar rates of “freeze-all embryos”, albeit more women had increased monitoring for ovarian hyperstimulation risk, related to the higher egg numbers in the highest IGF-1 quartile. The most striking clinical outcomes were that of the pregnancy productivity rate (including fresh and frozen embryo transfers from a single OPU) which was greatest in the highest IGF-1 quartile (61.5% vs 48.2% per OPU across all ages p<0.0002). Miscarriage rates were not different but live birth productivity rates were significantly greatest for the highest IGF-1 quartile (49% vs 33% per OPU across all ages; p<0.0002). We conclude that a preliminary measurement of the IGF-1 level can help to define the poor-prognosis female prior to IVF treatment and on whom adjuvant studies can be focused.

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17

Lynch, Elizabeth. "IVF misconceptions." Nursing Standard 18, no. 22 (February 11, 2004): 20. http://dx.doi.org/10.7748/ns.18.22.20.s32.

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18

Tuffin, Keith. "IVF failure." Narrative Inquiry 12, no. 1 (September 26, 2002): 67–76. http://dx.doi.org/10.1075/ni.12.1.11tuf.

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19

BARTELS, DITTTA. "Regulating IVF." Nature 334, no. 6183 (August 1988): 559–60. http://dx.doi.org/10.1038/334559d0.

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20

Ramsay, Sarah. "IVF successes." Lancet 345, no. 8944 (January 1995): 246. http://dx.doi.org/10.1016/s0140-6736(95)90233-3.

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21

Richards, T. "IVF update." BMJ 292, no. 6529 (May 3, 1986): 1156–57. http://dx.doi.org/10.1136/bmj.292.6529.1156.

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22

Setchell, M. E. "IVF update." BMJ 292, no. 6533 (May 31, 1986): 1462. http://dx.doi.org/10.1136/bmj.292.6533.1462-a.

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23

Page, H. "IVF update." BMJ 292, no. 6537 (June 28, 1986): 1740. http://dx.doi.org/10.1136/bmj.292.6537.1740-a.

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24

Cooney, L. G., I. Lee, M. A. Clapp, S. Bjorkman, M. Goldsammler, M. Sammel, B. Fisher, and A. Dokras. "PCOS IVF." Fertility and Sterility 110, no. 4 (September 2018): e115-e116. http://dx.doi.org/10.1016/j.fertnstert.2018.07.348.

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25

Bryson, Caroline A., and Anthony I. Traub. "Post IVF syndrome? Psychological implications of failed IVF." Obstetrician & Gynaecologist 4, no. 4 (October 2002): 201–4. http://dx.doi.org/10.1576/toag.2002.4.4.201.

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26

Gleicher, N. "A pilot study raising concern about utilization of low intensity IVF (LI-IVF) in place of standard IVF (S-IVF)." Fertility and Sterility 96, no. 3 (September 2011): S185—S186. http://dx.doi.org/10.1016/j.fertnstert.2011.07.721.

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27

John L Yovich, Syeda Zaidi, Minh DK Nguyen, and Peter M Hinchliffe. "Measuring IGF-1 and IGFBP-3 profiles in women seeking assisted reproduction; response of women categorized as poor-prognosis to recombinant growth hormone adjuvant therapy (Study 4)." GSC Biological and Pharmaceutical Sciences 13, no. 3 (December 30, 2020): 064–78. http://dx.doi.org/10.30574/gscbps.2020.13.3.0358.

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In this fourth study examining the relevance of measuring the IGF profile (IGF-1, IGFBP-3 and the ratio of IGFBP-3/ IGF-1) in women presenting for assisted reproductive technologies (ART), we have examined the influence of recombinant growth hormone (rGH) prescribed as an adjuvant on the profile. Of 1633 ART-naïve women who completed an assessment cycle (AC) workup, and which included an IGF profile, 941 women proceeded to an in-vitro fertilization ± intracytoplasmic sperm injection (IVF±ICSI) treatment cycle during the period January 2011 to December 2019. Among those women, 90 were prescribed rGH because they were classified as likely poor-prognosis cases on the basis of advanced age or evidence of severely reduced ovarian reserve parameters. These women had their IVF±ICSI treatment within 3-months of their AC and consented to a second IGF profile measurement 4-6 weeks during their rGH treatment phase. Of the 90 women prescribed rGH adjuvant, 71 used the adjuvant and 19 deferred the treatment, but still completed the second IGF-profile. The data showed that rGH caused a significant elevation in IGF-1 (p<0.0001) as well as its main binding protein, IGFBP-3 (p<0.001), albeit to a lesser degree. Consequently, the IGF ratio, considered a more reliable marker of IGF-1 activity, was shown to be significantly reduced towards the normal range (p<0.0001). The data of clinical outcomes from these 90 women as well as the entire 941 women entering the IVF±ICSI treatment are presented for comparison, noting these data are not suitable for statistical evaluation as the groupings are disparate and unmatched. Further studies are intended to show the clinical relevance of increasing the IGF-1 levels in the analytical investigation of rGH as an adjuvant in ART.

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Lavrenteva, K. I., N. S. Trifonova, E. V. Zhukova, L. S. Aleksandrov, A. I. Ishchenko, A. P. Nikonov, M. B. Ageev, et al. "Clinical features of multiple pregnancy after in vitro fertilization." Voprosy ginekologii, akušerstva i perinatologii 22, no. 3 (2023): 5–10. http://dx.doi.org/10.20953/1726-1678-2023-3-5-10.

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Objective. To study the course of multiple pregnancy after the use of different methods of assisted reproductive technologies. Patients and methods. A total of 234 patients with multiple pregnancy developed through in vitro fertilization (IVF) were examined: 99 patients under the surrogate motherhood program (IVF-SM), 68 women after IVF with donor oocytes (IVF-DO), and 67 patients after IVF with own oocytes (IVF-OO). Patient subgroups were formed based on the presence or absence of obstetric complications. Results. Univariate analysis of pregnancy course showed that the incidence of gestational hypertension was significantly higher in the IVF-DO group than in the IVF-SM and IVF-OO groups. Pre-eclampsia (PE) in patients in the IVF-DO group was significantly more common than in the IVF-SM group (OR: 5.87; 95% CI: 1.94–17.74, p < 0.0005). Intrahepatic cholestasis (11.7%) and gestational diabetes (7.3%) were also more common in the IVF-DO group, but these data were not statistically significant. In multivariate analysis adjusted for maternal age, the incidence of PE remained significantly higher in the IVF-DO group compared with the IVF-SM group (OR: 7.68; 95% CI: 1.64–35.84, p < 0.0055). There were no significant differences between the IVF-DO and IVF-OO groups (OR: 2.8; 95% CI 0.77–10.22, p < 0.1487) and the IVF-OO and IVF-SM groups (OR: 0.36; 95% CI 0.11–1.24, p < 0.1305). Conclusion. Multiple pregnancy following IVF-DO is significantly associated with a higher risk of pre-eclampsia and fetal growth restriction compared with the IVF-OO and IVF-SM groups. Key words: multiple pregnancy, oocyte donation, pre-eclampsia, surrogacy, in vitro fertilization

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Almind, Gitte Juul, A. Abraham-Zadeh, E. Faerch, F. Lindenberg, S. Smidt-Jensen, and S. Lindenberg. "Two modified natural in vitro fertilisation (IVF) protocols compared to conventional IVF treatment: Retrospective data from one Danish Fertility Centre." Obstetrics & Gynecology International Journal 12, no. 6 (December 2, 2021): 386–89. http://dx.doi.org/10.15406/ogij.2021.12.00610.

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Aim of study: Over the last decade, laboratory procedures in in vitro fertilisation (IVF) have improved. Hyperstimulated ovaries cause an overload of surplus embryos. The present study was designed to evaluate the efficiency of two different modified IVF cycle protocols trying to reduce the load of medication used for IVF: simple IVF (S-IVF), Tamoxifen 40 mg daily from day 2 in the cycle to ovulation induction) and mild IVF (M-IVF), Tamoxifen 40 mg daily and every secondary 150 IU Gonal F until ovulation induction. The study aims to evaluate their efficiency compared with our conventional IVF (C-IVF) using a short antagonist protocol. Methods: A retrospective cohort study including all patients admitted to IVF for unexplained infertility, tubal factor, and male factor. In all stimulated cycles patients aimed at having fresh embryos transferred and surplus good embryos cryopreserved. All patients were recruited in the same period and allocated to the different treatments on their own request. The study was conducted between June 2019 and February 2021. Results: In total the study included 976 IVF cycles. 651 cycles from C-IVF, 145 cycles from S-IVF and 180 cycles from M-IVF. Mean age in the groups were comparable. Mean number of eggs retrieved was 6.1 (C-IVF), 1.2 (S-IVF) and 3.0 (M-IVF). Pregnancy rate per fresh transfer was found to be 29% for C-IVF, 26% in the S-IVF group and for the M-IVF 20%. Conclusion: Modified IVF stimulation protocols may be an important step towards a simpler assisted reproductive technology (ART) approach. More tolerable for women, easier and cheaper for patients and society they maintain acceptable clinical pregnancy rates. Large prospective studies need to be performed in the future.

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Prabandani, Dyah Ayu, Sri Winarni, and Septo Pawelas Arso. "Scoping Review: Marketing Strategy of In Vitro Fertilization (IVF)." Journal of Social Research 2, no. 12 (November 13, 2023): 4219–26. http://dx.doi.org/10.55324/josr.v2i12.1552.

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IVF or In Vitro Fertilization (IVF) is a new service program so to increase consumer or patient interest, a marketing strategy is needed that can increase the number of consumers themselves. This research uses the scoping review method to determine the marketing of test tube babies or IVF by formulating questions using the concepts P (Indonesia and Overseas), C (Marketing Strategy), and C (IVF). The results show that the promotion of In Vitro Fertilization (IVF) services is more efficient by using promotions on social media, distributing brochures, collaborating with ob-gyn doctors, and placing advertisements on websites related to IVF or IVF services. Promotion of IVF or IVF services is carried out to increase the number of users or patients who use these services. Several promotional media are considered capable of attracting customers to use IVF or IVF services, including promoting on social media, distributing brochures, collaborating with ob-gyn doctors, and placing advertisements related to IVF or IVF services on websites.

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Prabandani, Dyah Ayu, Sri Winarni, and Septo Pawelas Arso. "Scoping Review: Marketing Strategy of In Vitro Fertilization (IVF)." Journal of Social Research 2, no. 11 (October 30, 2023): 4155–62. http://dx.doi.org/10.55324/josr.v2i11.1552.

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IVF or In Vitro Fertilization (IVF) is a new service program so to increase consumer or patient interest, a marketing strategy is needed that can increase the number of consumers themselves. This research uses the scoping review method to determine the marketing of test tube babies or IVF by formulating questions using the concepts P (Indonesia and Overseas), C (Marketing Strategy), and C (IVF). The results show that the promotion of In Vitro Fertilization (IVF) services is more efficient by using promotions on social media, distributing brochures, collaborating with ob-gyn doctors, and placing advertisements on websites related to IVF or IVF services. Promotion of IVF or IVF services is carried out to increase the number of users or patients who use these services. Several promotional media are considered capable of attracting customers to use IVF or IVF services, including promoting on social media, distributing brochures, collaborating with ob-gyn doctors, and placing advertisements related to IVF or IVF services on websites.

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Tan, Kun, Zhuqing Wang, Zhenni Zhang, Lei An, and Jianhui Tian. "IVF affects embryonic development in a sex-biased manner in mice." REPRODUCTION 151, no. 4 (April 2016): 443–53. http://dx.doi.org/10.1530/rep-15-0588.

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Increasing evidence indicates that IVF (IVF includes in vitro fertilization and culture) embryos and babies are associated with a series of health complications, and some of them show sex-dimorphic patterns. Therefore, we hypothesized that IVF procedures have sex-biased or even sex-specific effects on embryonic and fetal development. Here, we demonstrate that IVF-induced side effects show significant sexual dimorphic patterns from the pre-implantation to the prenatal stage. During the pre-implantation stage, female IVF embryos appear to be more vulnerable to IVF-induced effects, including an increased percentage of apoptosis (7.22±1.94 vs 0.71±0.76, P<0.01), and dysregulated expression of representative sex-dimorphic genes (Xist, Hprt, Pgk1 and Hsp70). During the mid-gestation stage, IVF males had a higher survival rate than IVF females at E13.5 (male:female=1.33:1), accompanied with a female-biased pregnancy loss. In addition, while both IVF males and females had reduced placental vasculogenesis/angiogenesis, the compensatory placental overgrowth was more evident in IVF males. During the late-gestation period, IVF fetuses had a higher sex ratio (male:female=1.48:1) at E19.5, and both male and female IVF placentas showed overgrowth. After birth, IVF males grew faster than their in vivo (IVO) counterparts, while IVF females showed a similar growth pattern with IVO females. The present study provides a new insight into understanding IVF-induced health complications during embryonic and fetal development. By understanding and minimizing these sex-biased effects of the IVF process, the health of IVF-conceived babies may be improved in the future.

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John L Yovich, Shanthi Srinivasan, Mark Sillender, Shipra Gaur, Philip Rowlands, and Peter M Hinchliffe. "Using growth hormone as an adjuvant in IVF: Live birth outcomes from various poor prognosis scenarios." GSC Biological and Pharmaceutical Sciences 15, no. 1 (April 30, 2021): 063–80. http://dx.doi.org/10.30574/gscbps.2021.15.1.0083.

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Following 5 recent studies at PIVET several female factors were defined which enabled the clear categorization for a poor prognosis in IVF, namely advanced female age ≥42 years, very low antral follicle count (AFC <5), very low serum anti-Mullerian hormone level (AMH<5pmol/L), serum Insulin growth factor-1 (IGF-1 level) in the lowest quartile, repetitive failed IVF cycles (≥3) and the failure of residual embryos to undergo cryopreservation. Following an Assessment Cycle (AC) to define the first 4 factors in IVF-naïve women, women were offered recombinant growth hormone (rGH) as an adjuvant at 1.0 IU daily for 6 weeks in the lead-up to the oocyte pick-up of their first IVF treatment cycle. Of 1173 women who proceeded directly into IVF after completing an AC, 252 women (21.5%) utilized rGH initiating 426 IVF cycles. Very low AFC and AMH levels were defined in 51 of the women who proceeded through 90 IVF treatment cycles utilizing rGH. Clinical outcomes included cancellation rates (reduced among rGH users, p<0.01), oocytes retrieved (no significant benefit from rGH), oocyte utilization (apparent benefit for rGH in older women with several factors), significant improvement in embryo utilization rates for older women with several factors (incremental cycles ≥3; p<0.002) or failure to achieve cryopreserved embryos (p<0.02). However, these benefits failed to translate into an improved pregnancy or live birth productivity rate nor a reduction in miscarriage rates; partly due to the low numbers of women with several poor prognosis factors. Furthermore, a note of caution emerged from this study as younger women who did not receive rGH had significantly better live birth outcomes (p<0.0001 from initiated cycles), regardless of the number of poor prognosis factors identified. Nonetheless, we encourage prospective studies to continue, focusing only on older women ≥40 years with low ovarian reserve and additional poor prognosis factors.

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von Wolff, Michael, and Isotta Magaton. "Klassische IVF vs. Natural-Cycle- und Minimal-Stimulation-IVF." Der Gynäkologe 53, no. 9 (August 3, 2020): 588–96. http://dx.doi.org/10.1007/s00129-020-04641-z.

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Sahin, G., A. Akdogan, N. Çalimlioglu, A. Durmaz, E. N. Tavmergen Goker, and E. Tavmergen. "Do multinucleated embryos in IVF cycles affect IVF outcome?" Fertility and Sterility 98, no. 3 (September 2012): S277—S278. http://dx.doi.org/10.1016/j.fertnstert.2012.07.1009.

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Lidegaard, Øjvind, Anja Pinborg, and Anders Nyboe Andersen. "Imprinting diseases and IVF: Danish National IVF cohort study." Human Reproduction 20, no. 4 (April 1, 2005): 950–54. http://dx.doi.org/10.1093/humrep/deh714.

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Oktay, Kutluk, Erkan Buyuk, Natalie Libertella, Munire Akar, and Zev Rosenwaks. "Fertility Preservation in Breast Cancer Patients: A Prospective Controlled Comparison of Ovarian Stimulation With Tamoxifen and Letrozole for Embryo Cryopreservation." Journal of Clinical Oncology 23, no. 19 (July 1, 2005): 4347–53. http://dx.doi.org/10.1200/jco.2005.05.037.

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Purpose To develop safe ovarian stimulation methods to perform in vitro fertilization (IVF) in breast cancer patients who wish to preserve their fertility via embryo cryopreservation before chemotherapy. Patients and Methods Sixty women (age range, 24 to 43 years) with breast cancer were prospectively studied. Twenty-nine patients underwent 33 ovarian stimulation cycles with either tamoxifen 60 mg/d alone (Tam-IVF) or in combination with low-dose follicle-stimulating hormone (TamFSH-IVF) or letrozole 5 mg in combination with FSH (Letrozole-IVF). After IVF, all resultant embryos were cryopreserved to preserve fertility. Recurrence rates were compared with controls (n = 31) who elected not to undergo IVF. Results Compared with Tam-IVF, both TamFSH-IVF and Letrozole-IVF patients had greater numbers of follicles (2 ± 0.3 v 6 ± 1 and 7.8 ± 0.9, respectively; P < .0001), mature oocytes (1.5 ± 0.3 v 5.1 ± 1.1 and 8.5 ± 1.6, respectively; P < .001), and embryos (1.3 ± 0.2 v 3.8 ± 0.8 and 5.3 ± 0.8, respectively; P < .001). Peak estradiol (E2) levels were lower with Letrozole-IVF and Tam-IVF compared with TamFSH-IVF. After 554 ± 31 days (range, 153 to 1,441 days) of follow-up, cancer recurrence rate was similar between IVF and control patients (three of 29 v three of 31 patients, respectively; hazard ratio, 1.5; 95% CI, 0.29 to 7.4), and this estimate was not affected by cancer stage. Conclusion The combination of low-dose FSH with tamoxifen (TamFSH-IVF) or letrozole (Letrozole-IVF) results in higher embryo yield compared with Tam-IVF. Recurrence rates do not seem to be increased, but the letrozole protocol may be preferred because it results in lower peak E2 levels.

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Timofeeva, O. S., I. A. Petrov, J. F. Gaifulina, O. A. Tikhonovskaya, S. V. Logvinov, Iu G. Samoilova, M. S. Petrova, et al. "Analysis of in vitro fertilization programs in patients with functual ovarian cysts and anovulatory infertility." Bulletin of Siberian Medicine 22, no. 4 (January 23, 2024): 107–13. http://dx.doi.org/10.20538/1682-0363-2023-4-107-113.

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Background. There are different opinions about the effect of functional ovarian cysts on the duration of controlled ovarian hyperstimulation, the dose of gonadotropins, the number and quality of collected oocytes and produced embryos, and the frequency of pregnancy.Aim. To analyze in vitro fertilization (IVF) programs in women with anovulatory infertility and ovarian retention.Materials and methods. A prospective study included 71 women aged 18–44 years. The main group (I) included patients (n = 38) with anovulatory infertility and functional ovarian cysts (FOC) diagnosed by ultrasound before enrollment in the IFV program. Patients of this group underwent ultrasound-guided transvaginal puncture of ovarian cyst followed by cytology. The comparison group (II) (n = 33) encompassed patients with anovulatory infertility without FOC, who went through the IVF program. The control group (III) included apparently healthy individuals (n = 15). The study algorithm included collection of clinical and anamnestic data of the patients, data of laboratory and instrumental studies, parameters of a stimulated IVF cycle, characteristics of oogenesis and early embryogenesis, and assessment of IVF program effectiveness.Conclusion. It was established that in FOC and anovulatory infertility, the number of collected oocytes was smaller; however, the number of the best quality embryos and the frequency of pregnancy did not differ.

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Mirashvili, Marina Ivanovna, Marina Sabirovna Zainulina, Sergey Alekseevich Selkov, and Alexander Mkrtichevich Gzgzyan. "Diskussionnye voprosy vedeniya zhenshchin s antifosfolipidnymi antitelami pri primenenii VRT." Journal of obstetrics and women's diseases 62, no. 3 (June 15, 2013): 26–33. http://dx.doi.org/10.17816/jowd62326-33.

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There are many controversies in the management antiphospholipid antibodies-positive women undergoing assisted reproductive technologies. Controversial and important is not only the effect of antiphospholipid antibodies (APA) on the success of IVF, but also approaches to the management of this group of women. The aim of this work was to study the prevalence of antiphospholipid antibodies in women with 3 or more IVF failures and effectiveness of IVF in women with APA treatment with membrane plasmapheresis before IVF and intravenous immunoglobulin during IVF. In women with 3 or more IVF implantation failure APA were detected in 35.95 % of cases. The use of intravenous immunoglobulin along with the standard therapy is a safe and effective for improvement of IVF outcomes in women with antiphospholipid syndrome (APS) or the presence of APA. The most effective is a combination of the membrane plasmapheresis therapy before IVF and intravenous immunoglobulin during IVF standard therapy including LMWH and low-dose aspirin in IVF protocol. This therapy in patients with the presence of APA increases the pregnancy rate after IVF to 46.15 %.

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Herman, Tünde, Szilvia Csehely, Mónika Orosz, Harjit Pal Bhattoa, Tamás Deli, Péter Török, and Attila Jakab. "Endokrin kórképek előfordulása és társulása in vitro fertilizációs programban részt vevő nők körében." Orvosi Hetilap 163, no. 18 (May 1, 2022): 712–19. http://dx.doi.org/10.1556/650.2022.32372.

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Összefoglaló. Bevezetés: Az endokrin betegségekhez társuló ovulációs diszfunkció gyakori vezető vagy társuló oka a női infertilitásnak, de optimális reprodukciós korban oki vagy ovulációindukciós kezeléssel többnyire rendezhető a fertilitás. Az in vitro fertilizációs (IVF-) kezelések vezető indikációi jelenleg az andrológiai és a női életkorból adódó, petefészek-eredetű infertilitás, de egyéb endokrin diszfunkció társulása befolyásolja a kezelési eredményeket. Célkitűzés: Az endokrin betegségek gyakoriságának vizsgálata az IVF-programban részt vevő párok nőtagjainál. Módszer: Az IVF-program előtti alkalmassági vizsgálatok során a vezető indikációtól függetlenül részletes endokrinológiai kivizsgálást végeztünk 231 nőnél (átlagéletkor 34 év). A vizsgálatok kiterjedtek a hypothalamus- és petefészek-funkcióra, a pajzsmirigyfunkcióra és pajzsmirigy-autoimmunitásra, a mellékvese-funkcióra, a szénhidrát-anyagcserére és az inzulinrezisztenciára. Az egyes endokrin betegségek előfordulásán túl azok társulási gyakoriságát is elemeztük. Eredmények: Az IVF vezető javallatainak megoszlása megfelelt a nemzetközi tendenciáknak, endokrin jellegű volt 87 esetben (37,6%; csökkent petefészek-tartalék: 55 eset és krónikus anovuláció: 32 eset). Társuló endokrin eltérést 141 esetben találtunk, így összesen 161 nőt érintett az endokrin diszfunkció (69,7%; átlagéletkor 35 év). Az endokrin diszfunkciók előfordulása gyakorisági sorrendben: pajzsmirigy-diszfunkció (32,5%), csökkent petefészek-tartalék (23,8%), pajzsmirigy-autoimmunitás (22,5%), polycystás ovarium szindróma (15,6%), inzulinrezisztencia (22,5%), elhízás (23,8%), hyperprolactinaemia (13,4%). Az endokrin betegségek társulása minden kórkép esetében fellelhető volt. Hypogonadotrop hypogonadismus 2, congenitalis adrenalis hyperplasia 1 esetben fordult elő. Nem találtunk endokrin eltérést 70 esetben (30,3%). Következtetés: Vizsgálatunk igazolja az endokrin diszfunkciók halmozott megjelenését és gyakori társulását az IFV-program résztvevőinél, bármely indikáció esetén. A részletes endokrin kivizsgálás és az IVF-kezelést végzők endokrin jártassága hozzájárulhat az IVF-kezelés sikerességéhez. Orv Hetil. 2022; 163(18): 712–719. Summary. Introduction: Ovulatory dysfunction associated with endocrine diseases is a common leading or associated cause of female infertility, but at optimal reproductive age, causal or ovulation-induction treatment can usually settle fertility. The leading indications for in vitro fertilization (IVF) treatments are currently andrological and originated from age-related ovarian infertility, but other accompanying endocrine dysfunctions affect treatment outcomes. Objective: To investigate the incidence of endocrine diseases in female members of couples participating in IVF program. Method: During aptitude tests prior to the IVF program, from the leading indication independently, a detailed endocrinological examination was performed in 231 women (mean age: 34 years). The studies of hypothalamic and ovarian function, thyroid function and thyroid autoimmunity, adrenal function, carbohydrate metabolism and insulin resistance were covered. In addition to the incidence of each endocrine disease, the frequency of their association was analyzed. Results: The distribution of IVF lead indications was in line with the international trends, it was endocrine nature in 87 cases (37.6%; decreased ovarian reserve in 55 cases and chronic anovulation in 32 cases). Associated endocrine abnormalities were found in 141 cases, and a total of 161 women was affected by endocrine dysfunction (69.7%; mean age: 35 years). Endocrine dysfunction incidences in order of frequency were thyroid dysfunction (32.5%), diminished ovarian reserve (23.8%), thyroid autoimmunity (22.5%), polycystic ovarian syndrome (15.6%), insulin resistance (22.5%), obesity (23.8%), hyperprolactinemia (13.4%). The endocrine disease associations were found in all of the cases above. Hypogonadotropic hypogonadism occurred in 2 cases, congenital adrenal hyperplasia occurred in 1 case. No endocrine abnormalities were found in 70 cases (30.3%). Conclusion: Our study confirms the cumulative appearance of endocrine dysfunctions and frequent association in IVF participants with any lead indication. The detailed endocrine examination and proficiency/skill in reproductive endocrinology of IVF practitioners may contribute to IVF treatment success. Orv Hetil. 2022; 163(18): 712–719.

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Izquierdo, Maxim, Sonia Baulies, Marta Devesa, Fransec Tresserra, Carmen Ara, Ignacio Rodriguez, Rafael Fabregas, Buenaventura Coroleu, Pedro S. Barri, and Pere Barri. "Breast cancer after IVF: Can ovary stimulation and follicular response affect prognostic factors?" Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e12538-e12538. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e12538.

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e12538 Background: The ovary stimulation and the follicular response is related with estradiol level. Study in breast cancer patients after IVF if ovarian response or number of IVF cycles affects the prognostic factors. Methods: Patients with breast cancer who underwent IVF are studied the prognostic factors (Ki67, HER2, estrogen receptor (ER), progesterone receptor (PR), oncogene p53, histologic grade) in relation to the ovary response and number of IVF cycles. Results: 73 patients with breast cancer after IVF are studied. They performed 135 cycles of IVF, 36 (49’3%) with 1 IVF and 37 (50’7%) with more than one IVF. Hyper response was present in at least one IVF in 24 (32.9%) patients and there was no hyper response in any IVF in 49 (67.1%) patients. The prognostic factors were: Ki 67> 20 in 31'91% (15/47) Ki 67 <20 in 68'08% (32/47), HER2 + 31'94% (23/72) HER2- 68'05% (49/72), p53 + 45'09% (23/51), p53-54'90% (28/51), HG II-III 56'36% (31/55), HG I 43'63% ( 24/55), RE + 87'5% (63/72), RE- 12'5% (9/72), RP + 76'38% (55/72), RP- 23'61% (17/72). None of prognostic factors varied with the ovary response (hyper response in at least one IVF cycle, normal response, normal or low response) (p=ns). The only prognostic factor that varied with the IVF number was p53 +. Patients with p53 + (23/51), 7 (30’43%) has one IVF, and 16 (69’53%) have more one IVF (p<0’05). Conclusions: In breast cancer after IVF, the ovary stimulation and the follicular response not affect Ki67, HER2, estrogen receptor, progesterone receptor, p53, and histologic grade. p53 positive is more frequent in patients with more than one IVF.

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Poursharif, B., J. Paden, and B. Acacio. "503. SUCCESSFUL IN VITRO FERTILIZATION (IVF) AFTER PRIOR FAILED IVF UTILIZING A PROPRIETARY BLEND OF SUPPLEMENTS." Reproduction, Fertility and Development 21, no. 9 (2009): 104. http://dx.doi.org/10.1071/srb09abs503.

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Background: To date, little is known about the effect of supplements on the outcome of in vitro fertilization (IVF). The data on this matter is limited to measuring the overall pregnancy rate on a population of women who took a specific supplement, and not on IVF patients. Objectives: To demonstrate the positive role of an investigated supplement in the outcome of patients undergoing IVF. Method: 18 women undergoing IVF treatment were placed on a proprietary combination of vitamins and antioxidants designed to encourage blood flow and improve egg quality. The women were selected for this protocol mostly due to prior poor egg quality and/or large amount of embryo fragmentation .The women took supplementation twice daily for 4–12 weeks prior to transfer. The charts of the patients who used the supplements were used to obtain data. Previous failed IVF was defined as negative pregnancy. Successful IVF outcome was determined by positive chemical pregnancy and clinical pregnancy after one attempt. Range and mean was calculated for patient's age and number of failed previous IVF attempts. The previous IVF attempts were performed in different centers without using this supplement in all patients. Results: Eighteen patients used the supplement before and during their IVF cycles. Patient's age ranged from 28 to 44 with mean of 36.4 years. They had on average, 2 prior failed IVF attempts. Seventeen of 18 patients had successful IVF outcome. The failed patient required frozen testicular extraction of sperm (TESE), prior to IVF. Summary: Seventeen of 18 patients who used our supplements had successful IVF. These patients failed an average of 2 previous IVF attempts without using our supplements. Conclusion: Usage of our supplements is associated with improved rates of success in patients undergoing IVF with a history of prior failed IVF attempts. Larger studies need to be conducted.

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Stanek, Meghan B., Sherri M. Borman, Theodore A. Molskness, Janine M. Larson, Richard L. Stouffer, and Phillip E. Patton. "Insulin and Insulin-Like Growth Factor Stimulation of Vascular Endothelial Growth Factor Production by Luteinized Granulosa Cells: Comparison between Polycystic Ovarian Syndrome (PCOS) and Non-PCOS Women." Journal of Clinical Endocrinology & Metabolism 92, no. 7 (July 1, 2007): 2726–33. http://dx.doi.org/10.1210/jc.2006-2846.

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Abstract Context: Vascular endothelial growth factor A (VEGF-A) is a potent cytokine that promotes angiogenesis and vascular permeability. After controlled ovarian stimulation (COS) for in vitro fertilization (IVF), excessive VEGF-A production can occur, particularly in women with polycystic ovarian syndrome (PCOS); however, it is unclear whether the regulation of VEGF-A production is different between PCOS and non-PCOS women. Objective: The aim of this study was to determine whether there were differences in the dose- and time-dependent effects of insulin and IGFs on VEGF-A production by luteinized granulosa cells (LGCs) from women with and without PCOS. Design and Setting: A prospective comparative experimental study was conducted at an institutional practice. Patients: Patients included six PCOS and six non-PCOS women undergoing COS and IVF. Interventions: Interventions included COS for IVF. Main Outcome Measures: VEGF-A levels in culture media were collected daily for 3 d from LGCs after incubation with variable doses of insulin, IGF-I, and IGF-II in the presence and absence of LH. Results: In both study groups, exposure to LH alone did not alter VEGF-A levels. However, insulin or IGF increased VEGF-A levels within 1 d and appeared to synergize with LH at 3 d. VEGF-A production by non-PCOS LGCs was more sensitive to IGF exposure, whereas PCOS cells were more sensitive to insulin. Although an increase in DNA content (P < 0.05) was noted in cultures of PCOS cells, progesterone levels were lower compared with non-PCOS LGCs. Conclusion: Insulin and IGFs promote VEGF-A production in LGCs, but the response patterns are different when cells from PCOS and non-PCOS women are compared.

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Yu, Guangji. "Axiomatic Characterizations of IVF Rough Approximation Operators." Mathematical Problems in Engineering 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/256372.

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This paper is devoted to the study of axiomatic characterizations of IVF rough approximation operators. IVF approximation spaces are investigated. The fact that different IVF operators satisfy some axioms to guarantee the existence of different types of IVF relations which produce the same operators is proved and then IVF rough approximation operators are characterized by axioms.

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G.R. Sultanova, V. Baltaci, and T.A. Sultanova. "Makrofaqların becərilməsinin effektivliyi immun vasitəli sonsuzluq." Actual Questions of Modern Gynecology and Perinatology 11, no. 1 (May 22, 2024): 20–24. http://dx.doi.org/10.28942/mgpam.v11i1.129.

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Məqalədə müəlliflər səbəbləri araşdırdılar Təkrarlanan IVF müvəffəqiyyətsiz və müasir istifadə təsvir edilmişdir İmmunitetlə əlaqəli düşüklərin aradan qaldırılması texnologiyaları. Müəlliflər onun qısa təsvirini verdilər hamiləlik dövründə baş verən proseslərin pozğunluqları immun mənşəli və mahiyyətini şərh etdi yeni üsul təklif etdi. Araşdırmaya 51 nəfər daxildirtəkrar uğursuz IVF keçirmiş qadınlar mənşəyi. Onlar aparılan müayinələri təsvir edirlər IVF-nin uğursuzluğunu təsdiqləmək üçün. Uğursuzları aradan qaldırmaq üçün IVF-nin nəticələri, müasir mütərəqqi metoddan istifadə edilmişdir - makrofaq; uğurlu Bütün qadınlarda IVF nəticələri əldə edilmişdir. faktı hamiləlik makrofaqların aşkarlanması ilə təsdiq edilmişdir və makrofaqdan sonra 14-cü gündə hCG və IVF proseduru. Makrofaq proseduru müəlliflər tərəfindən ən effektiv kimi təklif edilmişdir immun mənşəli təkrarlayan uğursuz IVF üsulu indiki. Tədqiqat işlərinin davam etdirilməsi zəruridir bu istiqamətdə.

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46

Etheredge, Francis. "On Regulating IVF." Ethics & Medics 41, no. 7 (2016): 1–2. http://dx.doi.org/10.5840/em201641713.

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The in vitro fertilization industry is generally unregulated in the United States, although individual states have enacted laws trying to rein in some of the more flagrant abuses of the practice. The weakness in the American system is the failure to protect the rights of experimental subjects, first expressed in the 1949 Nuremberg Code and again in the 1979 Belmont Report, which emphasized the need to protect those with diminished responsibility. Who is more vulnerable to mistreatment than the unborn? A different approach exists in Great Britain, where the national government regulates the production and use of human embryos. There are advantages to the British practice: it encourages scientists to publicize what they propose to do; it can focus the public on the objective good or harm of a particular proposal; and it makes it easier to identify the currents of thought which contribute to the political advocacy of IVF.

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47

Fost, N. "Access to IVF." Pediatrics in Review 20, no. 8 (August 1, 1999): 36e—37. http://dx.doi.org/10.1542/pir.20-8-e36.

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48

Fost, Norman. "Access to IVF." Pediatrics In Review 20, no. 8 (August 1, 1999): e36-e37. http://dx.doi.org/10.1542/pir.20.8.e36.

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Gleicher, Norbert, and David H. Barad. "‘Patient-friendly’ IVF." Expert Review of Obstetrics & Gynecology 5, no. 1 (January 2010): 1–4. http://dx.doi.org/10.1586/eog.09.65.

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GREENLAND, T. B. "Papal IVF poser." Nature 326, no. 6115 (April 1987): 734. http://dx.doi.org/10.1038/326734d0.

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