Dissertations / Theses on the topic 'IVF'
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Mansour, Ragaa Taha Ahmed. "Optimizing IVF results." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 2003. http://arno.unimaas.nl/show.cgi?fid=6122.
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Boden, Jane. "When IVF treatment fails." Thesis, University of Hull, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419766.
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Little is known of how patients cope when treatment fails and they are faced with the prospect of life without their 'own' child. Initial observations suggest that for some, the effects can be traumatic and long lasting. Thirty-five {narrative' interviews were carried out with patients and partners for whom treatment had failed five years previously. Transcripts were subject to formal thematic analysis. A significant factor, which emerged from a formal analysis of transcripts, was the role of 'hope'. Treatment offers the hope that they may have a child and this provides the motivation for treatment; alongside the urgent need to pre-empt future regrets. The failure of treatment does little to dent this hope as long as there is 'another chance', but not so when treatment is discontinued. Once the support provided by hope is removed, patients can struggle to make sense of their lives and patients may seek and need (but not receive) psychological support. A significant and unexpected finding was anger and the widespread feeling amongst patients that they had been abandoned at this time. It would appear that some form of closure regarding the ending of treatment is required. Research found some couples are able to reinvest in life goals and re-establish their relationships; however, there were a significant proportion of couples who were still struggling five years after their last attempt, to adapt to life without the child they had anticipated. Many couples move onto alternative options, i.e., adoption, however, not all couples recover from the trauma of the inability to parent at will and some relationships break down. There is an irrefutable lack of psychological support offered to couples going through assisted conception, and findings suggest indisputably that more support should be offered on a regular basis to couples going through this process and beyond
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Hammarberg, Karin. "Women's experience of IVF treatment /." Connect to thesis, 1998. http://eprints.unimelb.edu.au/archive/00002870.
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Holding, Jessica Anne. "IVF children's understanding of biological inheritance /." Title page, abstract and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09SS.PS/09ss.psh7278.pdf.
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Veleva, Z. (Zdravka). "Factors affecting the outcome of IVF/ICSI." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514288838.
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Fertility declines with advancing age and the number of couples seeking infertility treatment at an older age is constantly increasing. A top quality embryo is believed to have the highest potential for implantation and development into a child. A better understanding of the relative importance of patient and treatment characteristics and of embryo quality could help to optimise the existing therapeutic schemes and the safety of in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI).
In this work, databases of five Finnish infertility clinics were studied retrospectively. Data on treatments performed in the years 1994–2005 were collected. A total of 19,000 treatment cycles were analysed. Special attention was paid to the relative significance of the transfer of top quality embryos with regards to pregnancy, miscarriage, live birth and cost of treatment in the general IVF/ICSI patient population and in groups with expected poor outcome.
The results showed that the transfer of a top quality embryo is associated with a better chance of pregnancy and live birth. However, it does not diminish the probability of miscarriage. Both low and high BMI increase the miscarriage rate. Advancing age and a positive history of previous miscarriages are also associated with a higher probability of miscarriage. In addition, the need for hormonal substitution in cases of frozen-embryo transfer is a risk factor of miscarriage, probably because of suboptimal endometrial function.
Since the transfer of several embryos leads to multiple pregnancies, which are associated with a high risk of maternal and fetal complications, elective single embryo transfer (eSET) of a top quality embryo allows all additional good quality embryos to be frozen and transferred later in frozen-thawed embryo transfer cycles. The present work demonstrates that eSET is a safe treatment strategy at least until the age of 40. However, it might not be performed in women with fewer than four collected oocytes, since the prognosis might remain poor even if the response is improved in a following cycle.
When eSET is applied routinely and on a large scale, it diminishes treatment costs while increasing the number of deliveries occurring at term, making IVF/ICSI at the same time safer and more affordable even to patients without access to reimbursed IVF treatment.
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Coates, Alison. "Optimizing IVF outcomes in the genomics era." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/64357/.
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In order to optimize pregnancy rates during IVF cycle, we have to grow embryos in such a way to allow them to reach their full potential in-vitro. As IVF has evolved since the first live birth in 1978, culture conditions have improved and we have reached a stage where embryos can thrive to the blastocyst stage in-vitro if programmed to do so. IVF cycles typically produce multiple embryos during one cycle. Establishing which embryo has a higher potential to result in a live birth than its sibling embryos has been attempted over the last 30 years by using non-invasive and invasive techniques. Methods to choose which embryo to transfer range from basic morphology to establishing ploidy status of each embryo by biopsy. Aneuploidy is the most common cause of implantation failure and miscarriage in human reproduction and increases with maternal age, however all maternal ages exhibit varying degrees of embryonic aneuploidy. While some non-invasive techniques have shown promise in predicting which embryos have the highest implantation potential, the only way currently to establish ploidy status of embryos in the embryology lab is to biopsy, then assay embryonic cells before transfer. To improve IVF success, original studies derived from retrospective analysis of clinic data, or prospectively designed studies are essential and a number of fundamental biological questions pertaining to chromosome abnormalities and their relationship to IVF embryo development remain unanswered. The overall aim of this thesis was thus to provide further insight into the cytogenetic basis of early human development by pursuit of the following specific aims: (1) To test the hypothesis that we can predict aneuploidy levels in human IVF embryos without embryo biopsy for PGS by analysis of basic morphokinetic criteria and spent media from cell free embryonic DNA, (2) to test the hypothesis that the ICSI technique may create aneuploidy in embryos, (3) to establish novel patient populations that may benefit from the use of PGS, specifically male factor infertility patients and young oocyte donors, (4) conducting a randomized controlled trial (RCT) to establish the optimal transfer strategy (fresh vs frozen) for euploid embryos in patients using their own oocytes,(5) to test the hypothesis that identifying mosaic embryos among a cohort of embryos could increase live birth rates and reduce miscarriage rates by avoiding these embryos for transfer and (6) to use the data generated from PGS/IVF cycles to provide a framework for creating realistic expectations for patients planning for their fertility future. The conclusions of each aim were as follows: I demonstrated that poorer quality embryos showed an increased rate of aneuploidy but not large enough to predict aneuploidy for each individual embryo. Analysis of cell free DNA in spent culture media is at its early stages of development, but the study presented in this chapter using a novel WGA technique, showed that there is potential for its future use as a non-invasive PGS method. I found that aneuploidy rates were similar in embryos generated from normal sperm whether they were created using ICSI or standard insemination using a donor oocyte model to minimize the maternal age effect (aneuploidy rates of 21% for standard IVF vs 23% for ICSI. P= > 0.05 NS) concluding that the ICSI technique does not create embryonic aneuploidy. Donor oocyte recipients (average age of donor 25) benefited from PGS in cryopreserved embryo transfer cycles by significantly increasing live birth rates per embryo from 36% with no PGS to 59% per PGS screened embryo (p=0.0008). Male factor infertility patients presenting with oligozoospermia, were shown to exhibit a significantly higher incidence of sex chromosome abnormalities in pre-implantation embryos compared to patients with normal sperm using ICSI (6.1% for oligozoospermic samples vs 1.6% for normal semen samples. P=0.0007). Both of these patient groups could benefit from offering PGS as part of their IVF cycle. The RCT showed that freeze all cycles had higher live birth rates than fresh cycles (77% of frozen embryo transfers vs 59% of fresh embryo transfers. P=0.04). When comparing transfer of embryos screened by NGS with those screened by aCGH, the conclusion in the relatively small subset of patients was that live birth rates for embryos screened with aCGH and NGS appear to be similar, with a 2% trend in favor of NGS (61% aCGH vs 63% NGS live born offspring per embryo transferred. P= > 0.05 NS). Lastly, the retrospective analysis of data using PGS cycles to calculate how many oocytes are required to create one euploid blastocyst depending on maternal age, resulted in a useful tool to advise patients on how many cycles of IVF they may need to complete their family. Taken together therefore, this thesis provides fundamental insight into the chromosomal basis of early human development, introduces new referral categories for PGS and informs the practical use of IVF/PGS in the future.
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Emery, Josephine Angela. "Psychological aspects of IVF : a prospective study." Thesis, University of Manchester, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685728.
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Andze, Ramune [Verfasser], Joseph [Akademischer Betreuer] Neulen, and Ivo [Akademischer Betreuer] Meinhold-Heerlein. "Einfluss der Adipositas auf IVF- und ICSI-Ergebnisse / Ramune Andze ; Joseph Neulen, Ivo Meinhold-Heerlein." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1130871479/34.
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Ojala, Petra, and Emelie Svensson. "Ett förlorat ögonblick : Kvinnors upplevelser under IVF-behandlingen." Thesis, Högskolan i Borås, Institutionen för Vårdvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-20886.
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Ungefär vart femte par i fertil ålder drabbas av ofrivillig barnlöshet och många av dem genomgår då in vitro-fertilisering (IVF). Infertilitet och IVF- behandling kan leda till att upplevelsen av sig själv och sitt förhållningssätt till andra förändras och detta kan medföra ett lidande för kvinnorna. Antalet IVF behandlingar ökar för varje år och syftet med examensarbetet är att belysa kvinnors upplevelse under IVF- behandling. Genom en ökad kunskap kan vårdpersonal på ett mer tillfredställande sätt möta kvinnor som genomgår fertilitetsbehandlingar och minska deras lidande. Den valda metoden är en kvalitativ innehållsanalys och litteraturen är begränsad till självbiografier, som ger en mer detaljrik inblick i kvinnornas livsvärld. Resultatet är sammanställt efter en analys av fyra biografier och bygger på fyra huvudteman, ”Att förlora kontrollen”, ”Relationen till andra”, ”Ett intrång i kroppen” och ”Väntan”. Behandlingen medförde en stor psykisk och fysisk påfrestning för kvinnorna. De upplevde en kontrollförlust då IVF blev deras identitet och att kontrollen över den egna kroppen och känslolivet delvis gick förlorad. Kvinnornas relation till andra påverkades negativt, särskilt relationen till den egna partnern då samlivet förändrades. Vidare fanns det moment under behandlingen som kvinnor upplevde som ett intrång i den egna kroppen och som i de flesta fall var förenat med smärta och obehag. Det som upplevdes som mest påfrestande var väntan efter att ett embryo förts tillbaka till kvinnan och tills det att ett graviditetstest kunde göras, och utfallet av behandlingen konstateras. Upplevelsen av behandlingen är sammankopplad med upplevelsen av infertilitet och det uppstod stundtals svårigheter att skilja dessa åt. Resultatet visade att vårdpersonalen kunde göra skillnad för kvinnornas upplevelse av behandlingen genom att visa engagemang och medmänsklig kärlek.Program: Sjuksköterskeutbildning
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Pertoldová, Stanislava. "Vybrané faktory ovlivňující úspěšnost přenosu embryí po IVF." Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-256764.
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Assisted reproduction is a field of medicine that deals with infertility tretment.
Ongoing improvements of laboratory technology as well as ongoing evolving scientific research within IVF research,including experimental embryology in routine practice is contributing in a steady improvement of success rates of assisted reproduction.
This thesis is primarily based on data and information provided by the laboratory of assisted reproduction of GEST IVF Ltd.clinic in Prague,which was collected during the year 2015. This data was analyzed and investigated to verify the effect of selected factors on the success of the treatment. In This thesis we have not used any personal data of patients in accordance with the legislation act.296/2008Sb.
The results show clear evidence between the treatment success rate and patients age within all evaluated parameters. The fundametal hypothesis of interdependence of embryo quality on the further development of the embryo after the transfer was comfirmed.
Conversely, the timeframe for embryo cultivation is not an important parameter of success. Commonly used cuture media also did not show a significant impact on treatment outcome.
Statistical calculations also confirmed surprisingly significant differences in embryo transfer after 72 hours development and 120 hours development for women ever 35 years. Transfers of younger embryos appears to be more convenient for women over 35 years.
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Blencke, Petra. "Selektion feliner Oozyten für die IVF mittels Brillantcresylblau-Färbung." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-128528.
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Matsdotter, Madelene. "Enastående ensamstående? : Valet att bli solomamma med IVF-teknologi." Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-25460.
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Sveriges Riksdag beslöt våren 2012 att även ensamstående kvinnor ska få tillgång till assisterad befruktning i Sverige. Hittills, och än så länge, har ensamstående kvinnor rest utomlands för att fertilitetsbehandlas. Syftet med denna studie har varit att undersöka hur solomammor (kvinnor som valt att skaffa barn som ensamstående) resonerat och resonerar kring sitt val, samt hur de ser på faderskapsprocessen och den kommande lagändringen. Deltagare söktes via en förenings Internetsajt, där medlemmarna alla är frivilligt ensamstående mammor. Fem solomammor berättade om sina resonemang i semistrukturerade intervjuer. Sedan kategoriserades, kodades och tematiserades materialet, och analyserades med hjälp av symbolisk interaktionism, värderingsförändringar och samhällsutveckling. Resultaten visar bland annat att respondenterna verkligen tänkt igenom sitt beslut att bilda familj som ensamstående förälder. De ser främst ser lagändringen som symboliskt viktig, då deras familjeform i och med denna erkänns av samhället. Respondenterna tror att donatorbrist och åldersgränser i Sverige kommer att medföra att ensamstående kvinnor även fortsättningsvis reser utomlands för assisterad befruktning. De negativa åsikter som kommit fram rör sjukvårdskontakter i Sverige och hur en del ensamstående mammor blivit bemötta av socialtjänsthandläggare. Faderskapsprocessen skulle kunna bli mer rättssäker om tydliga, nationella regler utfärdades även för faderskapsutredningar som rör donatorbarn.The Swedish Riksdag decided in the spring of 2012 that single women also should have access to assisted reproduction in Sweden. Up until now, and so far, single women have travelled abroad for fertility treatment. The purpose of this study has been to explore how solo mothers (women who have chosen to obtain children as a single parent) reasoned and reason about this choice, and how they view the paternity process and the upcoming legislative changes. Participants were sought through an Internet site for an association where all members are single mothers by choice. Five solo mothers talked about their reasoning in semi-structured interviews. The material was then categorized, coded and thematized, and analyzed by using symbolic interactionism, changes in values and the development of society. The results show that the respondents really thought through their decision to found a family as a single parent. They see the legislative changes mainly as symbolically important, as their form of the family will be recognized by society. They believe that the lack of donors and the age limitations in Sweden will result in that single women continues to travel abroad for assisted reproduction technology. The negative opinions that have emerged during interviews are related to health care contacts in Sweden and how some single mothers have been treated by social service caseworkers. The paternity process could become more legally secure if clear, national regulations were issued also for the paternity process regarding donor children.
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Haapsamo, M. (Mervi). "Low-dose aspirin therapy in IVF and ICSI patients." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514296208.
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Abstract The first aim of this randomized, placebo-controlled and double-blind study was to investigate whether low-dose aspirin therapy, started prior to controlled ovarian hyperstimulation, improves ovarian stimulation response, uterine haemodynamics and clinical pregnancy rates in unselected patients who underwent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). The second aim was to examine if the maternal serum placental proteome is different in IVF/ICSI pregnancies compared with spontaneous pregnancies, and whether low-dose aspirin modifies maternal serum placental protein expression and uteroplacental haemodynamics during the first half of pregnancy. Finally, the effect of low-dose aspirin therapy on the incidence of hypertensive pregnancy complications among women who became pregnant after IVF/ICSI was investigated. Low-dose aspirin therapy did not increase the number of oocytes retrieved, the total number of embryos or number of top-quality embryos, endometrial thickness or uterine haemodynamics on the day of embryo transfer (ET) or clinical pregnancy rates compared with placebo-treated IVF/ICSI women. On the day of ET, low-dose aspirin did not affect UtA vascular impedance, but the incidence of non-optimal uterine artery haemodynamics (UtA PI≥3.0) was statistically significantly lower (p<0.05) in the aspirin group compared with the placebo group. In the placebo-treated IVF/ICSI patients, maternal serum proteome analysis showed altered protein expression compared with women with spontaneous pregnancies. Between aspirin- and placebo-treated IVF/ICSI patients, proteome analysis showed a unique and distinct pattern of differentially expressed proteins including extra-cellular matrix, complement and transport proteins. At 6 weeks’ gestation, arcuate artery PI and at 18 weeks’ gestation, UtA PI values were lower (p<0.05) in the aspirin group than in the placebo group. In conclusion, low-dose aspirin therapy, when started concomitantly with controlled ovarian hyperstimulation, did not improve ovarian responsiveness, uterine receptivity, pregnancy outcome in unselected IVF/ICSI women or affect UtA vascular impedance on the day of ET. Low-dose aspirin modified the early placentation process and reduced uteroplacental vascular impedance in mid-pregnancy, but did not decrease the incidence of hypertensive pregnancy complicationsTiivistelmä Keinoalkuisten hedelmöityshoitojen seurauksena keskimäärin reilu kolmannes naisista tulee raskaaksi hoitokertaa kohti. Näissä raskauksissa äidin seerumista määritettyjen istukkaperäisten merkkiaineiden pitoisuuksissa on eroavaisuuksia verrattuna spontaanisti raskaaksi tulleiden naisten seerumipitoisuuksiin ensimmäisen ja toisen raskauskolmanneksen aikana. Pre-eklampsian eli raskausmyrkytyksen riski on myös lisääntynyt. Syyksi arvellaan istukan verisuonipuuston poikkeavaa kehitystä. Pre-eklampsiaan liitetään intravaskulaarisen prostasykliinin ja tromboksaanin epätasapaino, joka johtaa verihiutaleiden aggregaation lisääntymiseen ja verisuonten supistumiseen. Matala-annoksinen asetyylisalisyylihappo (ASA) vähentää tromboksaanituotantoa ja korjaa tromboksaani- ja prostasykliinituotannon epätasapainoa, mutta sen ei ole todettu merkittävästi vähentävän näiden raskauskomplikaatioiden esiintyvyyttä edes riskiryhmillä, kun lääkitys on aloitettu toisen raskauskolmanneksen aikana. Tämän satunnaistetun ja plasebo-kontrolloidun kaksoissokkotutkimuksen tavoitteena oli tutkia keinoalkuisia hedelmöityshoitoja saavilla naisilla matala-annoksisen ASA-hoidon (100 mg/vrk) merkitystä munasarjojen stimulaatiovasteeseen, alkion kiinnittymiseen, istukan muodostumiseen ja kehittymiseen sekä lääkehoidon vaikutusta kohdun, istukan ja sikiön verenkiertoon, kun lääkitys aloitettiin munasarjojen stimulaatiohoidon alkaessa. Lisätavoitteena oli selvittää, onko lapsettomuushoitoja saavien naisten raskauksissa todettavissa spesifinen istukkaproteomiikkalöydös (istukan tuottamat valkuaisaineet) verrattuna spontaanisti raskaaksi tulleisiin naisiin ja voidaanko siihen vaikuttaa matala-annoksisella ASA-hoidolla. Toisena lisätavoitteena oli selvittää matala-annoksisen ASA-hoidon vaikutus pre-eklampsian esiintyvyyteen loppuraskaudessa. Matala-annoksinen asetyylisalisyylihappo (ASA) ei paranna keinoalkuisten hedelmöityshoitojen hoitotuloksia eikä vaikuta kohdun verenkiertoon tai kohdun limakalvon paksuuteen ultraäänellä arvioituna alkion siirtopäivänä. Matala-annoksista ASA-hoitoa käyttäneiden potilaiden ryhmässä todettiin kuitenkin merkitsevästi vähemmän naisia, joilla oli huonoa hoitotulosta keinoalkuisissa hedelmöityshoidoissa ennakoiva korkea molemminpuolinen kohtuvaltimoiden verenvirtausvastus alkion siirtopäivänä verrattuna plasebo-ryhmään. Raskaaksi tulleilla naisilla, jotka käyttivät matala-annoksista ASA-hoitoa, todettiin kohdun verenvirtausvastus matalammaksi alku- ja keskiraskaudessa verrattuna plasebo-ryhmän naisiin. Istukkaproteomiikkatutkimusten mukaan varhaisistukan proteiinituotanto on erilainen keinoalkuisissa raskauksissa verrattuna spontaanisti alkaneisiin raskauksiin ja siihen voidaan vaikuttaa matala-annoksisella ASA-hoidolla. Pre-eklampsian ja sikiön kasvunhidastuman esiintyvyydessä ei ryhmien välillä todettu eroa. Matala-annoksinen ASA-hoito aloitettuna ennen raskautta munasarjojen stimulaatiohoidon alkaessa ei paranna munasarjojen vastetta lapsettomuushoidoissa käytettäville hormonihoidoille, raskauslukuja eikä kohdun verenkiertoa alkion siirtopäivänä. Hoidon todettiin kuitenkin vaikuttavan varhaisistukan kehittymiseen sekä parantavan kohdun verenkierto alku- ja keskiraskaudessa viitaten istukan verisuonipuuston parempaan kehittymiseen. Matala-annoksinen ASA-hoito ei vähentänyt istukkaperäisten raskauskomplikaatioiden esiintymistä
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Weber, Mathias. "Konzeption und Implementierung eines CRM-Konzeptes Fallstudie IVF HARTMANN AG /." St. Gallen, 2007. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/01655109002/$FILE/01655109002.pdf.
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Morrison, Cheryl Beth. "IVF, an experimental procedure and the physician's duty to disclose." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0005/MQ28238.pdf.
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Montfoort, Aafke Philomena Anna van. "Prevention of twin pregnancies in IVF by single embryo transfer." [Maastricht] : Maastricht : Universitaire Pers Maastricht ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=8686.
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Murto, Tiina. "Folate, Hormones and Infertility : Different factors affecting IVF pregnancy outcome." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220476.
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Various hormones have been studied as regards prediction of pregnancy outcome after infertility treatment, but no ideal candidate has been found. Folate and genetic variations in folate metabolism have also been associated with infertility, but it remains unclear how these factors affect IVF pregnancy outcome. It is known that infertility is associated with active folic acid supplement use, but the effect of socioeconomic and lifestyle factors on folic acid supplement use in infertile women has not been well investigated. The overall aim of this work was to obtain information on the prediction of live birth, and to study factors affecting the role of folate and folic acid intake in relation to IVF pregnancy outcome. Infertile women with various infertility diagnoses were studied. Healthy, fertile non-pregnant women were used as controls in three of the studies. Blood samples were taken for assay of eight different hormones, folate and homocysteine, and for genomic DNA extraction. A questionnaire was used to assess background data and use of folic acid supplements. Twenty-four-hour recall interviews were performed for validation of the questionnaire. The studied hormones were not good predictors of live birth. The best predictor was age of the women, together with ovulatory menstrual cycles, and thyroid-stimulating hormone and anti-Müllerian hormone (AMH) status. Well-educated women, high-status employed women, and married and infertile women used the most folic acid supplements. Infertile women had better folate status than fertile women. However, pregnancy outcome after infertility treatment was not dependent on folic acid intake, folate status, genetic variation of 5,10-methylenetetrahydrofolate reductase or socioeconomic status. In conclusion, AMH levels vary less than those of other hormones during the menstrual cycle, and AMH could be used as a predictive marker of live birth together with age and ovulation. Folate might play a minor role in IVF pregnancy outcome, but the importance of folate as regards other health perspectives should not be forgotten.
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Throsby, Karen. ""Calling it a day" : the decision to end IVF treatment." Thesis, London School of Economics and Political Science (University of London), 2002. http://etheses.lse.ac.uk/110/.
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This thesis focuses on the experiences of women and couples who have undergone in vitro fertilisation (IVF) unsuccessfully and who have subsequently stopped treatment. The thesis is feminist in that it aims to make visible the gendered power relations within which IVF failure is experienced and accounted for. IVF is viewed here not as a neutral artefact, or the violent imposition of male power, but as a form of disciplinary technology, the experience of which is always contradictory and ambivalent. The thesis takes a discourse analytic approach to the interview data. This approach necessarily conceptualises the participants as active, but constrained, agents in the production of meaning in relation to IVF, and the analysis seeks to identify the discursive strategies which they employ in accounting for their experiences. It is argued that those who have stopped treatment occupy an ambiguous liminal space among the dominant discourses of gender, technology and body, and that this constitutes an unusually productive location from which to think about IVF, both in terms of challenging the apparent inevitability of those discourses and creating openings for the production of new knowledges. The analysis is organised around four key themes which emerged from the interview data: the negotiation of discourses of nature and technology; the location of IVF within consumer culture; the distribution of responsibility when treatment fails; and the seeking of resolution around the end of treatment. This thematic structure forms a platform from which to consider not only the specificities of the experience of IVF failure, but which also generates broader insights at the theoretical and conceptual level, focusing particularly on the limitations of oppositional paradigms of transgression / conformity, material / discursive, agency / constraint and theory / practice in the feminist theorising of IVF.
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Bonnet, Anke. "Einfluss unterschiedlicher Stimulationsprotokolle auf den Ausgang der IVF- bzw. ICSI-Therapie in der IVF-Sprechstunde der Universitäts-Frauenklinik Tübingen in den Jahren 1997 und 1998." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972906304.
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Simonavičienė, Aušra. "Pagalbinių apvaisinimo būdų taikymo etinės problemos pacientų požiūriu." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2007. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2007~D_20070803.110500-16012.
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Darbo tikslas. Išanalizuoti pagalbinių apvaisinimo būdų taikymo etines problemas pacientų požiūriu.
Uždaviniai. Ištirti ir palyginti vaisingų ir nevaisingų šeimų požiūrį į pagalbinius apvaisinimo būdus; Nustatyti etines problemas, kylančias nevaisingoms šeimoms, naudojant pagalbinius apvaisinimo būdus; Įvertinti nevaisingų šeimų požiūrį į pagalbinių apvaisinimo būdų įstatyminę bazę.
Tyrimo metodika. Anoniminė anketinė apklausa. Tirtos dvi respondentų grupės: nevaisingi asmenys (vaisingumo asociacijos nariai, n=93) ir vaisingi asmenys (besilaukiančios moterys, n=146).
Rezultatai. Didžioji dalis respondentų yra girdėję apie pagalbinius apvaisinimo būdus ir jų taikymą. Vaisingi asmenys linkę pritarti įvairiems IVF taikymo apribojimams (amžiaus riba, IVF tik susituokusioms poroms ir pan.), vaisingumo sutrikimų turintys asmenys linkę naudotis PAB be jokių apribojimų. Nevaisingi žmonės pritaria embrionų užšaldymui, donorystei bei surogatinei motinystei, siekdami išnaudoti visus įmanomus būdus pasiekti norimo nėštumo. Nevaisingų asmenų nuomone, būtiname DA įstatyme privalo atsispindėti embrionų šaldymas, donorystė bei procedūrų kompensavimo tvarka.
Išvados. 84,9 proc. visų tyrime dalyvavusių respondentų mano, kad nevaisingumas yra liga; 88,7 proc. visų respondentų yra girdėję apie pagalbinius apvaisinimo būdus.
Abiejų grupių respondentai pritaria tiek in vivo, tiek in vitro procedūroms. Nevaisingos šeimos perteklinių embrionų sukūrime, jų šaldyme, spermos ar kiaušialąsčių... [toliau žr. visą tekstą]Aim of the study. To analyse the patient‘s view of ethical issues in assisted reproductive technologies use. Objectives. To investigate and compare the fertile and infertile person‘s view of assisted reproductive technologies; To identify an ethical problems arising for infertile persons from assisted reproductive technologies use; To evaluate infertile person‘s view of assisted reproductive technologies legislative base. Methods. Anonymous questionnaire survey. Inquired two groups of respondents: infertile persons (members of Fertility Association, n=93) and fertile persons (pregnant women, n=146). Results. Most of respondents have heard about the use of assisted reproductive technologies. Fertile persons are minded to agree with various limitations of IVF use (age limit, IVF only for married couples, etc.), infertile persons prefer to use ART without any restrictions. Infertile people accept embryos cryopreservation, use of donors and surrogate motherhood, seeking to use all possibilities in order to receive pregnancy. According to infertile people opinion, new ART law is mandatory and must cover embryo cryopreservation, use of donors and reimbursement of procedures. Conclusions. 84.9 % of all respondents thinks, that infertility is a disease; 88.7 % of all respondents have heard about assisted reproductive technologies. Respondents of both groups approves in vivo and in vitro procedures. Infertile persons do not see serious ethical issues in creation of spare embryos... [to full text]
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Carlén, Ann, and Christina Wallbäcks. "I strävan efter föräldraskap : Kvinnor och mäns upplevelse av IVF-behandling." Thesis, Örebro universitet, Hälsoakademin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-20424.
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Introduktion: Ofrivillig barnlöshet, infertilitet, är ett vanligt problem som uppträder i alla kulturer. I Sverige är ungefär 10-15 % av alla par drabbade och det samma gäller i övriga Västeuropa och Nordamerika. Det är ungefär lika vanligt med manlig som kvinnlig infertilitet och relativt ofta i kombination. Hos 10-15 % av alla infertila återfinns ingen orsak till infertiliteten. Idag är in vitro fertilisering, IVF, den vanligaste behandlingsmetoden vid alla typer av infertilitet. Syfte: Syftet var att beskriva kvinnor och mäns upplevelse av att genomgå IVF-behandling. Metod: Studien genomfördes som en systematisk litteraturstudie som analyserades genom kvalitativ innehållsanalys. Resultat: Deltagarna upplevde att IVF-behandlingen förändrade och tog över livet. Behandlingen inverkade på parrelationen på olika sätt. IVF medförde också en påtaglig psykisk och känslomässig påfrestning. Hur deltagarna valde att förhålla sig till behandlingen påverkade upplevelsen. Barn och gravida skapade reaktioner som gav blandade känslor som följd. En bristande information inom vården och betydelsen av stöd var framträdande. Slutsats: IVF-upplevelsen påverkar livets alla delar och är en påfrestande upplevelse. Tydligt är behovet av information och stöd under behandlingen samt en individualiserad vård.
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Fathi, Eman Ibrahim. "Studies on the factors that improve the outcome of IVF-ET." Thesis, University of Hull, 2007. http://hydra.hull.ac.uk/resources/hull:8308.
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The overall purpose of this thesis was to identify factors which influence the outcome of IVF treatment and which might be amenable to modification in order to improve pregnancy rates following this form of treatment. To this end I performed a historical review of the advances that have been made in reproductive treatment since before the birth of Louise Brown in 1978, and a retrospective analysis of the result of a single IVF unit over a 6 year period from 1999 to 2005. This identified a number of factors on which IVF pregnancy rates depend. I found that there is a decrease in the pregnancy and implantation rates and an increase in the abortion rates with a consequent decrease in the live birth rate with an increase in the female age. The data demonstrated that the pregnancy, implantation, abortion, and live birth rates for female age 20-25 years was 42%, 21.95%, 37.5%, and 26.3% respectively. For the age of 26-30 years the comparative figures were 44.5%, 27.4%,12.34%, and 39%, for the age of 31-35 years 35.7%, 22%,16%, and 29.9%, for the age of 36-39 years 27%, 13.9%, 22.7%, and 20.5% and for patients who were 40 years and above 17%, 7.4%, 27.3%, and 12.9%. (P<0.05) for the pregnancy, implantation, and live birth rates, (P>0.05) for the abortion rate. In addition, I found that there is a decrease in the pregnancy rate with increasing age of the male partner although this did not reach a statistically significant level. For male patients whose age was between 20-30 years the pregnancy rate was 42.7% compared with 37.8% if they were between 31-44 years and 31.6% if they were 45 years or above (P >0.05). I found that the outcome of IVF-ET is affected by the number of embryos transferred, and whether the embryos are fresh or cryopreserved. The data showed that the pregnancy and implantation rates for single embryo transfer were 16.9%; for double embryo transfer were 37.3% and 23.22% respectively, and for triple embryo transfer 27.12% and 11.64% respectively. In addition, I found that the difference in the twin and triplet rates were 0% and 0% respectively for single embryo transfer, 24.5 and 0.02% respectively for double embryo transfer, and 26.8% and 1.5% respectively for triple embryo transfer. The differences in pregnancy and implantation rates between the transfer of two fresh and two frozen embryos were 37.3% versus 27.3% (P>0.05) and 23.22% versus 16.36% (P>0.05). The outcome of IVF-ET was also found to be affected by the grade and cleaving rate of embryos. The differences in the pregnancy and implantation rates between the transfer of high-grade and low grade embryos were 61.4% versus 11.5%, and 35.8% versus 6.96% (P<0.0001). The differences in the pregnancy and implantation rates after the transfer of slowly cleaving embryos or rapidly cleaving embryos transferred on day 2 was 18.3% versus 44% respectively (P<0.0001),and 11% versus 28% respectively (P<0.0001).Similar differences were seen between slowly or rapidly cleaving embryos transferred on day 3. The difference were 20% versus 63.4% respectively (P<0.017) for the pregnancy rate, and 13.3% versus 40.14% respectively (P <0.027) for the implantation rate. The day of embryo transfer was also relevant, with a better outcome when the embryos were transferred on day three rather than day two. The differences were 42.8% versus 35.1% (P<0.024) for the pregnancy rate and 27.43% versus 21.53% (P<0.005) for the implantation rate. Transcervical embryo transfer (TCET) was more likely than transmyometrial embryo transfer (TMET) to lead to pregnancy, whether the transfer was easy or difficult. The outcome of TMET was low even if it was easy. Zygote intrafallopian transfer (ZIFT) is preferred to TMET if at least one fallopian tube is patent. The outcome differs when different operators perform ET and the difference in the pregnancy rate for three different operators was found to vary between 35.2%, 41.2%, and 26.5% (P<0.026). The outcomes were good if nurses performed the procedure, and a new trainee was found to need around one year to become expert in the technique with pregnancy rates increasing from 34.54% to 47.3% at the end of one year of performing the procedures. I found also that the outcome was affected by the cause of infertility, with better outcomes when the aetiology was tubal, unexplained, or polycystic ovary syndrome (PCOS), and poorer outcomes when the aetiology was endometriosis, untreated hydrosalpinges or after a history of ectopic pregnancy. Differences in pregnancy rate according to aetiology varied between 61.9% and 11.8% (P <0.0001). By studying the results of the egg-sharing programme, I was able to show that aging of the ovary is more important than aging of the uterus and the outcome of IVF/ET in egg recipients is almost the same as the outcome in egg sharing donors. The pregnancy and implantation rates were 35.5%, and 18.33% respectively for egg recipients, and 35.5%, and 18.06% respectively for egg sharing donors. In addition, I found that abortion rates were higher and consequently live birth rates were considerably lower in the egg recipients as compared to the egg-sharing patients, abortion rates 26.19% versus 9%, P>0.05, live birth rates 26.5% versus 32.25%, P>0.05. Finally, I found that abortion rates were higher and consequently live birth rates were lower with increasing age of recipient. The abortion and live birth rates according to the recipient age were 18.75%, 30.95% respectively for recipients less than 35 years, 28.57%,26.31% respectively for those 36-39 years and 31.56%, 23.21% respectively for those 40 years and above, P>0.05. In addition, I found that the outcome is better when egg recipient patients have ovarian function as compared with egg recipient patients with no ovarian function, and the pregnancy rate was 41.3% for the first group and 29.62% for the second group, P>0.05. Egg sharing patients were found to have lower pregnancy and implantation rates while the live birth rate of egg sharing is virtually the same as standard IVF patients. The difference in the pregnancy, implantation, abortion, and live birth rates between the two groups was (35.52% versus 40.7%), (18.3% versus 25.61%), (9% versus 20.46%), and (32.25% versus 32.29%). Hence, egg sharing has no detrimental effect on the outcome for egg sharing patients. The only factor amenable to modification for each and every couple was identified as the technique of embryo transfer. Hence, I undertook a literature search to identify the effects of the technique that might be relevant. I also used time-lapsed ultrasound video imaging of the uterus as a means of identifying those cycles that might have a favourable or unfavourable outcome as a result of a good or poor ET technique. My results show that exaggerated junctional zone contractions do indeed have a detrimental effect on the outcome of IVF-ET our data shows that the pregnancy rate for those who had less than 5 uterine contractions per 2 minutes as compared to the pregnancy rate for patients who had more than 5 uterine contractions per 2 minutes was 29.7% versus 0% respectively p=0.026, but an easy embryo transfer did not appear to change the character or the frequency of junctional zone contractions.
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Irving, Laura. "IVF based approaches towards the treatment and prevention of mitochondrial disease." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2567.
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Mitochondria are strictly maternally inherited, with all paternal mitochondria being destroyed following fertilisation. Women known to be carriers of pathogenic mtDNA mutations are therefore at increased risk of conceiving affected children. These women are currently offered the following options to aid in genetic counselling: oocyte donation, prenatal genetic diagnosis (PND) or preimplantation genetic diagnosis (PGD). One of the aims of this thesis, was to examine the feasibility of PGD for mtDNA inherited disorders, with specific emphasis on answering the following questions: how accurately does the mutation load observed in the biopsied blastomeres reflect the mutation load in the remaining embryo, are those mutation loads initially observed in the biopsied blastomeres maintained throughout preimplantation embryonic development and do mutation loads observed in the inner cell mass reflect those mutation loads observed in the extra-embryonic trophectoderm cells? In my thesis, I have now been able to provide data towards answering each of these questions through the examination of mutation loads in oocytes, embryos and blastocysts obtained from mitochondrial patients undergoing fertility treatment. Techniques, which have been developed in my current laboratory, have facilitated the characterisation of a nuclear transfer technique known as pronuclear transfer (PNT). This is a method to prevent the transmission of mitochondrial DNA disease from mother to child (Craven et al, 2010). As part of the work for my thesis, I have examined the reproducibility of the PNT technique by assessing whether the procedure could be performed by different operators, whilst maintaining levels of efficiency, survival and developmental outcome. Experiments are now being performed to examine the feasibility of PNT in normally fertilised human zygotes, created from donated oocytes. As it is unlikely that egg collection will be possible from two independent donors on the same day, the final purpose of this study was to examine the potential and feasibility of vitrification of eggs or fertilised embryos at both the pronuclear (PN) and Metaphase II (MII) stage for the purpose of the PNT technique. In summary, my studies has examined the reliability of current methods to reduce the likelihood of having a child affected by a mitochondrial DNA disorder and new techniques currently being developed to prevent the transmission of defective mitochondrial DNA, altogether. I hope this will provide fresh hope for patients with mitochondrial DNA disease.
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Rahman, Noraiza Abdul. "Facing up to in vitro fertilisation (IVF) in Malaysia : questions of why and how IVF should be regulated within the framework of Malaysian cultural and religious values." Thesis, Lancaster University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654966.
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Titterington, Joanne. "Cryopreservation of murine pre-embryos : formulation of complex vitrification solutions and investigation of their effect on subsequent developmental potential post-thaw in vitro and in vivo." Thesis, University of Hull, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363182.
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Moore, Ruth Anne Marie. "Meeting the needs of patients : an examination of the role of two satellite assisted conception centres." Thesis, University of Huddersfield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270404.
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Cahill, David John. "Preovulatory follicular function and fertilisation in women with endometriosis." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295058.
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Ström, Åse, and Tina Johansson. "IVF-processen. Parets upplevelse av vårdens bemötande, samt processens påverkan på parrelationen." Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-25780.
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Av par i fertil ålder som aktivt försöker få barn är det 10-15 procent som inte lyckas inom ett år och räknas då till kategorin ofrivilligt barnlösa. Att drabbas av ofrivillig barnlöshet innebär stor sorg och prövning för det drabbade paret. Med hjälp av assisterad befruktning kan parets möjligheter till graviditet öka. En IVF-process innebär psykisk och fysisk påfrestning, vilket ställer stora krav på vårdens bemötande, kompetens och stöd. Denna studie syftar till att undersöka hur par som genomgår IVF-behandling upplever vårdens bemötande samt om och i så fall hur parets relation påverkats under och efter IVF-processen. Studien har en kvalitativ ansats och för att uppfylla syfte och besvara frågeställningar har semistrukturerade intervjuer använts som metod. Undersökningen består av fem intervjupar vilka genomgått eller genomgår en IVF-process. Resultatet visar att respondenterna från en början upplevde ett varmt och välkomnande bemötande, men att det efterhand förändrades. Respondenterna beskriver brister hos vårdpersonalen såsom kränkning, kompetens- och tidsbrist. Vidare framgår att flertalet upplever att de blivit bemötta som en i mängden, framförallt av läkare, då de inte fått den individanpassade vård som krävdes. Resultatet visar att paret under IVF-processen utsätts för flertalet påfrestningar, vilket kan vara krävande för parrelationen. Trots detta upplever paren att påfrestningarna medfört en stärkt parrelation.Of couples of reproductive age who are actively trying to conceive, 10-15 percent fails within a year, and is then counted in the category of involuntary childlessness. Couples that suffer from infertility often experience great emotional distress. With the help of assisted reproduction, the couple's possibility of a pregnancy may increase. The IVF process involves mental and physical stress, which leads to heavy demands on health care treatment, expertise and support. This study aims to examine how couples undergoing IVF treatment experienced the response they received from health care system. This includes whether or not the couple's relationship was affected during and after the IVF treatment process and if so how it was affected. The study was made with a qualitative approach. Semi-structured interviews have been our method for obtaining data this study. The study is based on interviews of five couples who underwent, or are still undergoing an IVF treatment process. The results show that respondents initially experienced a warm and friendly welcome from the health care system, but it gradually changed for worse. The respondents describe what they see as inadequacies of healthcare providers such as offensiveness, lack of skills, and time constraints. Furthermore, it appears that the majority feels that they have been overlooked, especially by doctors, when they did not receive the personalized care they needed. The results show that during the IVF treatment process the couples are subjected to intense and varying forms of stress that can be hard on their relationships. Despite the strain it has put on them, the couple's feel that it has strengthened their relationships.
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Rosenlund, Björn. "Management of severe male infertility with special reference to IVF and ICSI /." Stockholm, 1998. http://diss.kib.ki.se/1998/19980327rose.
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Jones, Christopher A. "Economic evaluation of alternative embryo transfer policies in in vitro fertilisation (IVF)." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426399.
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Upstone, Lisa. "A longitudinal investigation of the impact of IVF treatment on marital satisfaction." Thesis, University of Hull, 2002. http://hydra.hull.ac.uk/resources/hull:10450.
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This longitudinal study aimed to investigate into the impact of IVF treatment on marital satisfaction. The study was based upon the psychological sequelae model of infertility and encompasses the framework of the family systems theory. The study consisted of two groups, an IVF group (10 couples) and a comparison group (16 couples). Measures of marital satisfaction (Golombok-Rust Inventory of Marital State, Rust, Bennun, Crowe & Golombok, 1988) and marital happiness (Marital Happiness Scale, Azrin, Naster & Jones, 1973), as well as measures of mood and emotional state (Hospital Anxiety and Depression Scale, Zigmond & Snaith, 1983) were obtained before starting treatment, after the completion of treatment and at a one-month follow up. The results of the study found no significant differences between the two groups or between the sexes in each group on measures of marital satisfaction, happiness, depression or anxiety at the pre, post and follow up stages. Responses to additional questions given to the IVF group at the post treatment stage, suggested that undergoing IVF treatment had a positive effect on individuals' marriages and a sense that it had brought them closer together. The implications of these results and possible further experimental work is discussed.
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Östgård, Malin, and Gereben Elisabeth Damström. "Processen att försöka göra barn : kvinnors upplevelse av att genomgå IVF- behandling." Thesis, Röda Korsets Högskola, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-59.
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Infertilitet är en utbredd problematik som drabbar många par världen över. Olika behandlingsformer finns att tillgå för att hjälpa infertila par att uppnå en graviditet. IVF-behandling är en vanlig behandlingsform. Många studier visar att IVF-behandling påverkar kvinnan mer än mannen psykiskt. Syftet med denna studie var att beskriva hur kvinnor upplever processen att genomgå IVF-behandling. Metod: En litteraturstudie gjordes på tio kvalitativa artiklar för att besvara syftet. En innehållsanalys gjordes på dessa artiklar, där meningsbärande enheter identifierades i artiklarnas resultat. Dessa enheter kondenserades, grupperades och formade sub-kategorier och teman. Livsvärldsperspektivet användes som en teoretisk referensram. Resultatet av denna litteraturstudie blev sju teman; Tro på behandlingen; Okunskap; Påverkan på vardagen; Bemötande i relationer; Negativ hantering; Rädsla, samt Väntan. Slutsatser som drogs av denna litteraturstudie var att kvinnornas upplevelser var övervägande negativt präglade, men en tro på behandlingen var ändå en central upplevelse. Det är viktigt för berörda kvinnors omgivning att inneha ett livsvärldsperspektiv inför kvinnornas upplevelser av behandlingen. En ökad förståelse från kvinnornas omgivning skulle kunna ge kvinnorna bättre upplevelser av att genomgå behandlingen.Infertility is a widespread problem that affects many couples worldwide. Various treatments are available to help infertile couples achieve conception, and IVF is a common form of treatment. The psychological impact of the IVF-treatment affects the woman more than the man. The aim of this study was to describe how women experience the process of going through IVF treatment. Method: A literature review was done on ten qualitative articles to answer the aim of the study. A content analysis was done on these articles, and meaningful units were identified in the articles‟ results. These units were condensed, grouped and then formed into sub-categories and themes. A Life-World perspective was used as a theoretical framework. The result of this study was seven themes: Faith in the treatment; Ignorance: The impact on daily life; Responding in relationships, Negative handling, Fear, and Wait. Conclusions of this study were that women's experiences were predominantly negatively characterized, but a faith in the treatment was still a central experience. It is important for the women‟s surroundings to hold a Life-World perspective to women's experiences of the treatment. A greater understanding from the women's surroundings may improve the women‟s experiences of going through the treatment.
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Gharani, Pedram. "Modeling spatial accessibility for in-vitro fertility (IVF) care services in Iowa." Thesis, University of Iowa, 2014. https://ir.uiowa.edu/etd/1459.
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Tneh, Shao Heung. "Feasibility Study on Implementing IVF Hardware to Achieve Human Reproduction in Space." Thesis, Luleå tekniska universitet, Institutionen för system- och rymdteknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-76571.
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Markhinin, Vitaly G. [Verfasser]. "Hat die Spermienherkunft Einfluss auf die IVF-Resultate bei Kryptozoospermie? / Vitaly G. Markhinin." Köln : Deutsche Zentralbibliothek für Medizin, 2013. http://d-nb.info/1033312754/34.
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Fleming, Charlotte F. "Possible mechanisms of subfertility : epidemiological studies of in vitro fertilisation." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390337.
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Dörner, Diana. "Einfluss chromosomaler Aberrationen der Frau auf Verlauf und Ausgang von IVF- und ICSI- Behandlungen /." Düsseldorf, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000278432.
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Cheung, Ka-lung. "Proteomic profiling of uterine flushing from IVF patients : comparison between natural and stimulated cycles /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36434164.
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Cheung, Ka-lung, and 張嘉隆. "Proteomic profiling of uterine flushing from IVF patients: comparison between natural and stimulated cycles." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B4501064X.
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Ludwig, Oliver [Verfasser]. "Zum Stillverhalten von Frauen nach IVF/ICSI : Spielen psychosoziale Faktoren eine Rolle? / Oliver Ludwig." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1067842721/34.
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El-Shenawy, M. A. M. A. "Automatic detection and identification of cells in digital images of day 2 IVF embryos." Thesis, University of Salford, 2013. http://usir.salford.ac.uk/28425/.
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Medical image processing has experienced dramatic expansion, and has been an interesting research field that attracted expertise from applied mathematics, computer sciences, engineering, biology and even medicine. This work is concerned with developing image processing techniques to automate the detection and classification of cells in digital images of day 2 embryos for suitability for In Vitro Fertilization (IVF) treatment. In IVF treatment eggs are removed from the ovaries of the woman and injected with sperms of the man in a dish in the laboratory so that fertilization can take place and yield embryos. The embryos are then graded and examined to decide which embryos are the best to be re-implanted into the woman's womb again. The grading system used in this work involved day 2 embryos, and a dataset of 40 images was provided by Al Agyal clinic in Alexandria. At this stage of development the embryos should have 4 approximately circular cells with similar sizes in order to be considered as suitable for re-implantation. The work develops an automated image processing system which firstly locates the embryo in a microscope image, and then detects the cells in the embryo and matches their properties against the criteria for re-implantation. Although the main problem was the overlapping of the cells in the images, it was also found that the size (magnification) and the brightness also varied from one image to another and these factors had to be taken into consideration during the development of the detection algorithms. Once the perimeter of the embryo had been located, several edge detection techniques including the Sobel, Prewitt and Canny operators were examined as pre-processing for the circular Hough Transform. From 94 cells, only 62 cells (65%) were detected, but at the same time 226 of false cells were also detected. As an alternative approach, template matching was investigated, using templates with a range of sizes which were selected to match the acceptable size criteria for re-implantation and at the same time take into consideration the different magnification scales of the images used. The Sum of Added Differences (SAD) and the Normalized Cross Correlation (NCC) were used as a measure of the match. The NCC technique gave better results than SAD, which failed to detect any true cells. NCC technique only detected 50% of true cells, and further refinement to this approach was made. This involved binarisation of the images and templates, and the creation of two new edge-detection algorithms, one of which was based on the convolution technique while the other was based on the difference of the grey level between the border of the cell and its background. These changes have increased the cell detection accuracy to 80%, and reduced the detection of false cells from 118 to 39. Of the 40 images available, 30 images were used to develop the automated system while 10 images were left to test the performance of the system. In the case of the 10 images, 5 had larger embryos and 5 smaller ones than the 30 images, where the embryos had similar sizes. It was found that 85% of the cells in the 10 images were properly detected with only 6 false cells found. As the missed cells and false cells were distributed among the 40 images, only 8 were analysed correctly (all true cells detected and no false cells found) but these were all correctly identified as suitable or not suitable for re-implantation. Further work is required to improve the cell detection algorithm, and to decrease further the number of false cells detected and hence improve the classification of the embryo.
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Glad, Mathias, and Helene Asplund. "Oro och nedstämdhet hos heterosexuella par som genomgår behandling med ägg- eller spermiedonation." Thesis, University of Gävle, Department of Caring Sciences and Sociology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-738.
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Varje år föds barn runt om i världen som ett resultat av ägg- och spermiedonation. I Sverige är äggdonation laglig sedan 2003. Spermiedonation är reglerat i lag sedan 1984. Syftet med denna studie var att undersöka graden av oro och nedstämdhet som rapporteras från heterosexuella par som genomgår behandling med ägg- eller spermiedonation. Deltagarna i studien var män och kvinnor som genomgått ägg- eller spermiedonation vid ett av de sju infertilitetscentra som finns i Sverige. Det var totalt 348 män och kvinnor som besvarade två enkäter, den första vid behandlingens början och den andra ca 10 veckor efter avslutad behandlingen. Bortfallet var 16 %. Datainsamlingen gjordes med HADS – Hospital Anxiety and Depression scale. Efter att datan bearbetats statistiskt visade resultaten följande signifikanta skillnader. 1. Kvinnorna rapporterade högre grad av oro än männen både före och efter behandlingen samt högre grad av nedstämdhet efter behandlingen. 2. Både kvinnornas och männens grad av nedstämdhet var högre hos de par där behandlingen inte resulterade i graviditet jämfört med de par som blev gravida. 3. De kvinnor som inte blev gravida visade mer oro efter ett negativt behandlingsresultat än de kvinnor som blev gravida.
Slutsatsen från föreliggande studie är att kvinnor som genomgår behandlingar med ägg- eller spermiedonation känner mer oro och nedstämdhet än sina partners. Känslorna är av övergående natur och minskar då behandlingarna resulterar i graviditet.
Every year children all over the world are born as a result of gamete donation. In Sweden oocyte donation has been legally used since 2003 and sperm donation has been regulated in law since 1984. The aim of this study was to investigate the extent of anxiety and depression in couples going through treatments with oocyte- or sperm donation. Participants of the study were men and women who received treatment with oocyte- and sperm donation at one of the seven fertility centers in Sweden. A total of 348 men and women answered two questioners, the first one at the beginning of the treatment and the second one around 10 weeks after the end of the treatment. The drop-out rate was 16 percent. Data collection was made with the HADS – Hospital Anxiety and Depression scale. When the data had been statistically processed the results showed following significant differences: 1.The women reported a higher degree of anxiety than the men before as well as after the treatment and a higher degree of depression after the treatment. 2. The extent of depression was higher among those women and men who didn´t become pregnant compared to those who did. 3. The women who didn´t become pregnant were more anxious after failed treatment than the women who became pregnant. The conclusion is that women who receive treatment with oocyte- or sperm donation are more anxious and depressed than their partners. The feelings are temporary and seem to decrease when the treatment results in pregnancy.
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Joels, Lisa Anne. "The predictive value of sperm assessment prior to in vitro fertilisation." Thesis, University of Bristol, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310655.
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Liu, Yunao, and 劉蘊奡. "Human endometrial gene expression profiling and receptivity in patients undergoing in vitro fertilization (IVF) treatment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085404.
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Islam, Rumana. "The use of kisspeptin as a novel physiological trigger for oocyte maturation in IVF treatment." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/56868.
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Background: Infertility affects one in six couples (1) and hence is an important health issue, which can have significant medical, psychological and financial implications for couples. In vitro fertilization (IVF) is an effective treatment for infertility. However, one of the major complications that can arise from IVF treatment is ovarian hyperstimulation syndrome (OHSS). OHSS is predominantly related to the mode of triggering oocyte maturation during IVF treatment. It has been previously reported that a single dose of kisspeptin results in an LH-surge of ~12-14hrs duration, which safely triggers oocyte maturation in women at high risk of OHSS, but has yet to be directly compared with other triggers. I hypothesised that increasing the duration of LH-exposure by administering a second dose of kisspeptin could further optimise oocyte maturation without increasing the incidence of OHSS. Ovarian volume and ascitic fluid are commonly used to categorise the severity of OHSS in diagnostic guidelines. I also aimed to address if ovarian volume at early OHSS screening (day 2-10 following oocyte retrieval) altered when using different triggers of oocyte maturation (hCG, GnRH agonist or kisspeptin). Methods: This was a phase-2 single-blinded randomised placebo-controlled trial of 62 women at high risk of OHSS undergoing IVF treatment at Hammersmith Hospital, 5 London, UK. Following a recombinant FSH/GnRH-antagonist superovulation protocol, all patients (n=62) received a subcutaneous injection of kisspeptin-54 (9.6nmol/kg) 36hrs prior to oocyte retrieval. Patients were then randomised 1:1 to receive either a second dose of kisspeptin (D; Double, n=31), or saline (S; Single, n=31) 10hrs thereafter. Oocytes were retrieved transvaginally 36h after kisspeptin injection, assessed for maturation (primary outcome), and fertilised by intracytoplasmic sperm injection with subsequent transfer of one or two embryos. A second retrospective study was conducted assessing all women at high risk of OHSS (antral follicle count ≥23), aged < 35yrs, BMI < 30 kg/m2 with both ovaries intact, for sonographic signs and for OHSS symptoms during early OHSS screening (2-10 days following oocyte retrieval) at Hammersmith Hospital, London, UK (2013-2016). Ovarian volume on ultrasound, ascitic volume and OHSS symptoms were determined when patients were triggered with (hCG) (n=44), GnRH agonist (GnRHa) (n=94) or kisspeptin (n=115) at time of early OHSS screening. Results A second injection of kisspeptin significantly induced further LH-secretion at 4hrs and 10hrs after injection compared to saline (P < 0.0001). A higher proportion of patients achieved satisfactory oocyte yield following a second dose of kisspeptin (S:45.2%, D:71.0%; absolute difference +25.8%, CI 2.1-49.5%, P=0.042). There was no difference in the frequency of OHSS between the two groups. The mean 6 implantation rates following a double dose were higher (37.1±48.2%) when compared to a single dose (23.3±43%) of kisspeptin. Average mean ovarian volume (MOV) following hCG trigger was 172mls ±89mls, 88 ±60mls after GnRHa trigger and 53±37mls following kisspeptin trigger (p < 0.0001). The mean change in ovarian volume from baseline to OHSS screening for hCG was 166±87mls (25-fold), 75±56mls (10-fold) with GnRHa and 41±35mls (6-fold) following kisspeptin (p < 0.0001). OHSS symptoms were reported most frequently following hCG and least with kisspeptin. Conclusion Administering a second dose of kisspeptin safely improves oocyte yield in women undergoing IVF treatment. Kisspeptin may thus present a safer alternative than GnRHa or hCG triggering in patient at high risk of OHSS.
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Bottomley, L. "'Doing family' through Reciprocal IVF : an exploration of how LGBQ+ women experience becoming 'genetic mothers'." Thesis, City, University of London, 2018. http://openaccess.city.ac.uk/19931/.
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Shifts in social customs, legal developments and advancements in reproductive technology in the UK over the last few decades have facilitated the growth of ‘planned’ LGBQ+ families, where children are conceived within the current LGBQ+ relationship, with the intention of raising them within the family context. A more recent method of conception is Reciprocal IVF, where one partner’s eggs are collected, fertilised with donor sperm and transferred into the other partner, who then carries the pregnancy and gives birth. However, despite its increasingly popularity, little is known about the experiences of women who conceive through Reciprocal IVF. This research study explores how LGBQ+ women who share their eggs with their partner as part of Reciprocal IVF, experience the process of becoming a ‘genetic mother’. Data were collected from seven participants using semi-structured interviews and analysed using Interpretative Phenomenological Analysis (IPA). Emergent themes reflect the ways in which the women’s decisions, experiences and meaning-making were shaped by heteronormative discourse on family. The research considers what influenced their decisions to conceive through Reciprocal IVF and assume the role of egg donor, what factors supported and/or undermined their sense that they had had a child together with their partner, and explores the development of their parental identities and how they managed threats to these. Implications for Counselling Psychologists are discussed in terms of their work with clients and responsibilities to advocate for social justice. Suggestions for future research exploration are also made.
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Gürtin-Broadbent, Zeynep Başak. "The ART of making babies : Turkish IVF patients' experiences of childlessness, infertility and Tüp Bebek." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648190.
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Liu, Yunao. "Human endometrial gene expression profiling and receptivity in patients undergoing in vitro fertilization (IVF) treatment." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085404.
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BATTISTELLA, ALICE. "Atomic Force Microscopy-based essay for biomedical applications." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2996075.
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The investigation of cellular mechanical properties for the evaluation of the cell physiological state
has emerged as a hot topic in the last decade. In this framework, different aspects of the mechanobiology are considered in three biomedical fields. First, the alteration of the mechanical phenotype, the cell structure and morphology of melanoma cells according to the levels of production of a factor involved in the cytoskeleton organization, are considered. Secondly, mechanotransduction, and more precisely the capability of cells to adapt their mechanics to the environmental condition was investigated on the effect of a heart failure on cardiac pericytes. In the last part, the mechanical properties of oocytes have been identified as a scoring system to evaluate the quality of oocytes to be selected for the practice of the in vitro fertilization. In particular, I investigated the evolution of the oocyte stiffness and viscosity during post-ovulatory ageing, one of the processes responsible for the decreased yields of in vitro fertilization. Here, two mechanical parameters were found, able to predict ageing status of the oocytes before any visual feature due to degradation. allowing to introduce a novel classification for pre-apoptotic and non-fertile oocytes.The investigation of cellular mechanical properties for the evaluation of the cell physiological state has emerged as a hot topic in the last decade. In this framework, different aspects of the mechanobiology are considered in three biomedical fields. First, the alteration of the mechanical phenotype, the cell structure and morphology of melanoma cells according to the levels of production of a factor involved in the cytoskeleton organization, are considered. Secondly, mechanotransduction, and more precisely the capability of cells to adapt their mechanics to the environmental condition was investigated on the effect of a heart failure on cardiac pericytes. In the last part, the mechanical properties of oocytes have been identified as a scoring system to evaluate the quality of oocytes to be selected for the practice of the in vitro fertilization. In particular, I investigated the evolution of the oocyte stiffness and viscosity during post-ovulatory ageing, one of the processes responsible for the decreased yields of in vitro fertilization. Here, two mechanical parameters were found, able to predict ageing status of the oocytes before any visual feature due to degradation. allowing to introduce a novel classification for pre-apoptotic and non-fertile oocytes.
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Wiegank, Ulrike. "Bestimmung von Parametern zur Vorhersage eines ovariellen Überstimulationssyndroms in einem Kollektiv von Patientinnen zur IVF-ICSI." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974507555.
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