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Academic literature on the topic 'ITRAX'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "ITRAX"

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Othman, Faisal, Yamin Wang, and Furqan Le-Hussain. "The Effect of Fines Migration During CO2 Injection Using Pore-Scale Characterization." SPE Journal 24, no. 06 (July 15, 2019): 2804–21. http://dx.doi.org/10.2118/192076-pa.

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Summary Recent laboratory studies have shown that fines migration induces a decrease in rock permeability during CO2 injection. This study uses X–ray microcomputed tomography (micro–CT), nitrogen permeability, and Itrax X–ray fluorescence (Itrax–XRF) scanning to investigate the mechanism of fines migration during CO2 injection. We perform CO2–flooding experiments on two Berea core samples. The cores are characterized using nitrogen permeability, micro–CT, scanning electron microscopy with energy–dispersive X–ray spectroscopy (SEM–EDS), and Itrax–XRF scanning. The cores are flooded with fresh water, then CO2–saturated water, and finally water–saturated supercritical CO2 (scCO2). To calculate permeability, the pressure difference across the core samples is monitored during these fluid injections. The produced–water samples are analyzed using inductively coupled plasma–optical emission spectrometry (ICP–OES). After the flooding experiments, nitrogen permeability, micro–CT, SEM–EDS, and XRF scanning are repeated to characterize pore–scale damage. Micro–CT image–based computations are run to estimate permeability decrease along the core–sample length after injection. Results show the dissolution of dolomite and other high–density minerals. Mineral dissolution dislodges fines particles, which migrate during water-saturated–scCO2 injection. During CO2–saturated–water injection, the permeability of Berea 1 and Berea 2 increase by 29 and 13%, respectively. After water–saturated–scCO2 injection, the permeability of Berea 1 and Berea 2 decrease by 60%. The permeability damage of the sample can be explained by fines migration and subsequent blockage. SEM–EDS images also show instances of pore blockage.
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Sarraj, Sara, and Małgorzata Szymiczek. "Organosilicon polymer for the release of antimicrobial drugs." Polimery 67, no. 4 (May 13, 2022): 149–57. http://dx.doi.org/10.14314/polimery.2022.4.2.

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An organosilicon polymer was developed for the release of antimicrobial drugs. The influence of the drug itraconazole (Itrax) on polymer properties such as density, hardness, rebound resilience, tensile strength, accelerated aging, structure and antifungal activity was investigated. There were slight changes in physicochemical properties and significant deterioration of mechanical ones. The evaluation of the fungicidal activity showed time-limited antifungal properties.
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Rodrigues, Sandra, and Joan Esterle. "Core scanner technologies: take everything without breaking." APPEA Journal 56, no. 2 (2016): 595. http://dx.doi.org/10.1071/aj15101.

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Modern core scanning technologies, such as hyperspectral CoreScan™ or X-ray fluorescence (XRF) Itrax, which allow data acquisition without the necessity of breaking the core for speciality analysis, are receiving increasing interest in coal and CSG industries in the past few years. Such technologies are able to characterise and evaluate mineral matter in greater detail than conventional sampling and analyses, producing mineral maps and mineral/elemental profiles throughout the core. Although mineralogical information is the main output from both techniques, CoreScan™ has the ability of producing organic profiles that allow the recognition of the different lithotypes in the coal based on the spectral reflectance as well as rank, which makes a potential technique for coal quality. On the other hand, XRF Itrax core scanner allies the chemical elemental profile, from major to trace elements, with an X-radiographic image, creating a dynamic duo between stony partings and coal, and within the coal between bright and dull lithotypes, through contrasting image properties. These emerging technologies will allow coal reservoirs to be analysed quickly and reliably without subsampling that could introduce bias from the user.
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Gadd, Patricia, Karthik Gopi, Jesmond Sammut, Neil Saintilan, Jagoda Crawford, and Debashish Mazumder. "Itrax micro X-ray fluorescence (µXRF) for soft biological tissues." MethodsX 5 (2018): 1267–71. http://dx.doi.org/10.1016/j.mex.2018.10.001.

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Gregory, Braden R. B., Eduard G. Reinhardt, Andrew L. Macumber, Nawaf A. Nasser, R. Timothy Patterson, Shawn E. Kovacs, and Jennifer M. Galloway. "Sequential sample reservoirs for Itrax-XRF analysis of discrete samples." Journal of Paleolimnology 57, no. 3 (February 1, 2017): 287–93. http://dx.doi.org/10.1007/s10933-017-9944-4.

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Li, Tong, Renguang Zuo, and Guoxiong Chen. "Investigating fluid-rock interaction at the hand-specimen scale via ITRAX." Journal of Geochemical Exploration 204 (September 2019): 57–65. http://dx.doi.org/10.1016/j.gexplo.2019.05.008.

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Löwemark, Ludvig, Menno Bloemsma, Ian Croudace, J. Stephen Daly, Robin J. Edwards, Pierre Francus, Jennifer M. Galloway, et al. "Practical guidelines and recent advances in the Itrax XRF core-scanning procedure." Quaternary International 514 (April 2019): 16–29. http://dx.doi.org/10.1016/j.quaint.2018.10.044.

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Kelloway, Sarah J., Colin R. Ward, Christopher E. Marjo, Irene E. Wainwright, and David R. Cohen. "Calibration for ED-XRF profiling of coal cores for the Itrax Core Scanner." Powder Diffraction 29, S1 (October 20, 2014): S28—S34. http://dx.doi.org/10.1017/s088571561400089x.

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Recent developments in instrumentation mean that chemical analysis of large drill cores taken for geological purposes can be performed rapidly at sub-millimetre scales using core scanners equipped with energy-dispersive X-ray fluorescence spectrometers. The present study describes the development of a calibration for the Itrax Core Scanner (Cox Analytical, Sweden), intended for whole cores of coal-seam sections, without the need for sample preparation. The calibration was developed for key major elements (Al, Si, P, S, K, Ca, Ti, and Fe) based on pressed pellets of reference coals, allowing semi-quantitative and, at times, quantitative analyses. The influence of core curvature and surface roughness compared with an ideal flat-surface was also examined using model samples, and their influence on the apparent sample composition evaluated.
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Croudace, Ian W., Anders Rindby, and R. Guy Rothwell. "ITRAX: description and evaluation of a new multi-function X-ray core scanner." Geological Society, London, Special Publications 267, no. 1 (2006): 51–63. http://dx.doi.org/10.1144/gsl.sp.2006.267.01.04.

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Mondal, Md Nurunnabi, Keiji Horikawa, Osamu Seki, Katsuya Nejigaki, Hideki Minami, Masafumi Murayama, and Yusuke Okazaki. "Investigation of Adequate Calibration Methods for X-ray Fluorescence Core Scanning Element Count Data: A Case Study of a Marine Sediment Piston Core from the Gulf of Alaska." Journal of Marine Science and Engineering 9, no. 5 (May 17, 2021): 540. http://dx.doi.org/10.3390/jmse9050540.

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X-ray fluorescence (XRF) core scanner elemental count data are useful for high-resolution paleoceanographic studies. However, because several factors, such as changes in physical core properties, significantly affect element count intensities, the appropriate calibration of the count data is required. Besides, the existing approaches for calibration were not widely employed and require rigorous testing based on sediment variety. In this study, we analyzed high-resolution element intensity (cps) using a wet muddy marine sediment piston core that was collected from the northeast Gulf of Alaska and tested several approaches with ratio and log-ratio methods, and the reliability was evaluated by comparison with the concentrations that were measured by WD-XRF and an elemental analyzer. The results show that the lighter elements (Ti and K) exhibited a significantly weak relationship between raw counts measured by ITRAX and concentrations that were measured by the WD-XRF, indicating that some factors artificially influence ITRAX intensity data. The Cl intensity that is expressed as the water content in marine sediment increased significantly in the upper 202 cm by 42% and the top 25 cm by 73% as compared to the down-core (below 202 cm), which deviates the X-ray scattering and element-counts. The calibration of raw data through coherent/incoherent X-ray scattering ratio (CIR) and additive- and centered-log ratio reduces the offsets. The calibration by CIR performed best for Sr, Fe, Mn, Ti, Ca, K, and Br (0.56 < R2 < 0.91), and the correlation with concentration significantly increased for Ti and K of 100% and 56%, respectively. Therefore, the study suggests that the correction of raw counts through CIR is an effective approach for wet marine sediment when core physical properties have greater variability.
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Dissertations / Theses on the topic "ITRAX"

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Jarvis, Stuart. "Optimising, understanding and quantifying Itrax XRF data." Thesis, University of Southampton, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580571.

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The Itrax core scanner provides rapid, high resolution, non-destructive sediment core analysis using x-ray fluorescence (XRF) spectrometry and x-radiography. The effect of varying instrument settings are explored. Effects of sample properties on XRF data are tested and the uncertainty in XRF data is considered. Existing methods of quantifying XRF data are evaluated. Comparisons are made with other XRF micro-scanners. Finally, the x-radiographic capability of the Itrax core scanner is compared to x-ray computed tomography. Itrax XRF data is generally optimised by use of a 30kV x-ray tube voltage. Current should be set as high as possible without generation of sum peaks (30mA is often a good value). A chromium anode tube is suitable for use with most samples. Water content has a diluting effect on detected peak areas, but it is shown that the effect can be corrected, removing an obstacle to quantification of Itrax data. Water content can be determined non-destructively from the ratio of incoherent to coherent scatter of characteristic radiation from the x-ray tube anode. Surface slope can change recorded peak areas, but a simple model is developed to correct for this effect. Surface roughness increases variability in data and, if the scale of roughness is similar to the beam size, elemental peak areas may be reduced. The presence of a mixture of grain sizes greatly reduces peak areas for elements in the larger grains. The uncertainty in Itrax data is found to be higher than suggested by the conventional estimate that uncertainty is equal to the square root of the peak area. This information is vital for researchers to decide what significance they should attach to variations in Itrax elemental profiles. Quantification methods for core scanner XRF data are compared and an approach using log-ratio transformations determined to be the best. Additionally, an improved entirely non-destructive, quantification approach is presented in which explicit corrections are made for the diluting effect of water (water content may determined from the ratio of incoherent and coherent scatter of the tube anode characteristic radiation) . Compared to similar instruments, the Itrax core scanner is more tolerant of surface imperfections. Its x-radiographic scanning helps to determine the significance and extent of features revealed in XRF data. Itrax x-radiography provides no match for the level of detail that can be obtained using x-ray computed tomography and is not readily quantified. It does however provide information on features below the sample surface and, in masking small variations, can make the main core features more apparent. Users of the Itrax core scanner are provided with quantification of known effects (water content, surface slope; x-ray tube, current and voltage) and are alerted to issues that were not previously widely known (mixing of grain sizes, size of uncertainty in data). The areas of effective use and limitations of the Itrax core scanner are set out and recommendations made for optimising results. An optimal quantification method is identified. Many of the conclusions may have relevance to other XRF core scanners.
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Lau, Edward, and 劉家明. "Combinatorial use of SCX and RP-RP separation for iTRAQ-based quantitative proteomics profiling." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44923120.

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Burat, Bastien. "Apports de la protéomique quantitative différentielle haut-débit à l'étude des mécanismes de modification du cytosquelette de cellules tubulaires proximales induits par les Inhibiteurs de la Calcineurine." Thesis, Limoges, 2017. http://www.theses.fr/2017LIMO0104/document.

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En transplantation d’organe solide, les Inhibiteurs de la Calcineurine (ICN), Cyclosporine A et Tacrolimus, ont permis un amélioration significative de la survie à court terme du greffon en prévenant le rejet d’allogreffe. Cette évolution positive est contrebalancée par une néphrotoxicité susceptible de contribuer au développement complexe et multifactoriel de la dysfonction chronique du greffon, facteur pronostique majeur d’une insuffisance rénale terminale. L’objectif principal de ce travail a été de combiner deux approches expérimentales complémentaires, afin de mettre en lumière des aspects inédits de la physiopathologie des ICN. La première approche repose sur l’application de la technique de protéomique quantitative« shotgun » iTRAQ (« isobaric Tags for Relative & Absolute Quantitation ») à l’analyse non ciblée du protéome de cellules tubulaires proximales. La seconde approche applique de manière ciblée les outils classiques de biologie moléculaire à l’étude du cytosquelette d’Actine de cellules tubulaires proximales. La combinaison de ces deux stratégies complémentaires a permis de mettre en lumière un rôle inédit du cytosquelette d’Actine dans les effets physiopathologiques de la Cyclosporine A en apportant des éléments en faveur d’un mécanisme reposant sur une régulation originale de la dynamique intracellulaire de l’Actine
In solid organ transplantation, Calcineurin Inhibitors, Cyclosporin A and Tacrolimus, prevent allograft rejection and ensure short-term allograft survival. However, CNI elicit nephrotoxic side effects whose mechanisms remain widely unsolved and are thought to participate to the multifactorial development of chronic kidney disease, leading to renal failure. The aim of thiswork was to combine targeted and untargeted experimental strategies to better understand CNI-induced physiopathological mechanisms.The first approach was based on the untargeted monitoring of the proximal tubular proteome by the quantitative shotgun proteomic technique, iTRAQ (« isobaric Tags for Relative & Absolute Quantitation »). The second approach consisted in the study of the Actin cytoskeleton of proximal tubular cells by classical molecular biology techniques. In the light of results from both approaches, this work reported that the Actin cytoskeleton of proximal tubular cells may play a part in the pathophysiology of CsA thanks to a mechanism based on an original regulation of the intracellular dynamics of Actin
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Rusilowicz, Emma Victoria. "Chemical biology approaches for the identification of novel p53 regulatory signalling pathways." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/11774.

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p53 is a critical tumour suppressor which acts to repair or remove abnormal cells and thus prevent cancer. Aberrant function of p53 is therefore a critical step in tumourigenesis and p53 is mutated in half of all cancers. Mutation of p53 leads to both a loss of normal wildtype function as well as the gain of oncogenic function. p53 is considered to be a promising therapeutic target and therapeutic strategies for targeting of the p53 pathway include: 1. Activation of wild-type p53 (wtp53) protein function, 2. Refolding of mutant p53 (mtp53) into the wtp53 conformation, 3. Reduction of mtp53 protein levels. In this work a number of small molecule screening assays were used to identify potentially novel regulators of both wtp53 and mtp53. Screening of a protein kinase inhibitor library for small molecules which can stimulate wtp53 activity identified the GSK3 pathway and a CDK pathway as dominant suppressors of wtp53 function. Screening of the library for inhibitors which reduce mtp53 protein levels led to the identification of two IKKβ inhibitors. The work then focused on investigating the effects of one of these compounds, IMD0354, on the mutant p53 pathway; with a specific focus on MDM2 as the most rapidly responding biomarker. IMD0354 is a well characterised inhibitor which has been shown to specifically inhibit IKKβ leading to the repression of the Nf-κB pathway. This study shows that IKKβ inhibition leads to the loss of a number of oncogenic proteins including mtp53, MDM2 and cyclin D. Mass-spectrometry based (ITRAQ) proteomic analysis was then employed to identify potential mediators and/or co-regulated factors in response to IKKβ-inhibition via IMD0354 treatment. This led to the identification of RPS3 as a potential negative regulator of MDM2 protein expression; the reduction in MDM2 protein in response to IMD0354 treatment is shown to be partially dependent on RPS3. Together this data has identified, using small molecule kinase inhibitor libraries: (i) dominant kinase signalling pathways that suppress wt-p53 and (ii) a dominant kinase signalling pathway that sustains expression of mutant p53 and MDM2 in cancer cell lines. This latter data supports further investigation to aid understanding of how the IKK signalling pathway cross-talks to the p53-MDM2 axis.
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Talantikite, Maya. "Étude protéomique, cellulaire et moléculaire des fonctions de la métalloprotéase BMP-1 dans le contexte de la cicatrisation cornéenne." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1148.

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La cicatrisation cornéenne représente un processus de réparation complexe qui vise à restaurer l'intégrité, la structure et la transparence de la cornée. Cependant, dans un certain nombre de cas, ce processus peut évoluer de façon anormale et se stabiliser en entraînant la formation d'une opacité cornéenne installée. Les mécanismes impliqués dans la formation de ces cicatrices persistantes ne sont pas encore complètement élucidés, mais il est établi que la composition et l'organisation de la matrice extracellulaire du stroma jouent un rôle majeur dans la restauration de la transparence de la cornée. Ce projet s’est concentré sur la métalloprotéase extracellulaire BMP-1 (Bone Morphogenetic Protein 1), déjà connue pour son rôle dans l'assemblage de la matrice extracellulaire et l'activation du TGF-bêta. Afin d’identifier les processus contrôlés par BMP-1 dans la cornée, nous avons d’abord effectué une comparaison systématique des inhibiteurs de BMP-1 connus ou potentiels, de différentes origines, pour caractériser leurs propriétés à la fois in vitro et dans des cultures cellulaires. Ensuite, nous avons mené une étude approfondie du sécrétome des cellules stromales de la cornée humaine (kératocytes), et des conséquences de la différenciation de ces cellules en myofibroblastes. Enfin, nous avons analysé les événements protéolytiques médiés par BMP-1 dans le sécrétome des kératocytes en utilisant principalement une approche de protéomique quantitative basée sur le marquage iTRAQ des protéines entières (technique TAILS). La comparaison des inhibiteurs disponibles de BMP-1 a permis de mettre en évidence différents profils d’efficacité, de spécificité et de toxicité et a conduit à l’identification d’un inhibiteur hydroxamate et d’un inhibiteur protéique efficaces, peu toxiques et très spécifiques de BMP-1. Le sécrétome des kératocytes s’est avéré être un modèle adéquat pour l’étude des activités de BMP-1 dans le contexte cornéen. Plus de 2022 protéines ont été identifiées, dont la métalloprotéase BMP-1 et 16 de ses 33 substrats connus jusqu’à présent. Enfin, 76 protéines modifiées par l’activité de BMP-1 ont été identifiées dans le sécrétome des kératocytes. Ces résultats confirment les liens forts entre BMP-1, l'assemblage de la matrice extracellulaire et le TGF-bêta, mais suggèrent également de nouveaux rôles pour la protéase dans l'inflammation. Certains des substrats nouvellement identifiés (TGFBI, HSP47 et collagène VI) sont très pertinents dans le contexte de la cicatrisation de la cornée et ont été validés d’un point de vue biochimique. En conclusion, BMP-1 est confirmée comme une cible potentielle intéressante pour traiter ou prévenir la formation des opacités cornéennes et la caractérisation des inhibiteurs disponibles ouvre des perspectives importantes pour des études précliniques chez l’animal
When the cornea is injured, a complex multi-step healing process is triggered which aims at restoring corneal integrity, structure and transparency. However, in some cases, corneal healing results in the formation of a stable scar associated with a prolonged loss of corneal transparency and with functional blindness. The mechanisms involved in the formation of these persistent scars are still not fully understood but it is known that the composition and organization of the extracellular matrix significantly contributes to the maintenance of corneal transparency. This work focused on the extracellular metalloproteinase called BMP-1 (Bone Morphogenetic Protein 1), a major player in the control of extracellular matrix assembly and TGF-beta activation, which was previously shown to be up-regulated in corneal healing and scarring. In order to further probe BMP-1 functions in corneal healing, we first performed a systematic comparison of known or potential BMP-1 inhibitors from different origins to characterize their properties both in vitro and in cell cultures. We then carried out an in-depth study of the secretome of human corneal stromal cells (keratocytes) and of the consequences of the differentiation of these cells into myofibroblasts. Finally, we analyzed BMP-1-mediated proteolytic events in keratocyte secretomes, mainly using a quantitative proteomic approach based on iTRAQ labeling of proteins (TAILS technique). The comparison of BMP-1 available inhibitors revealed different profiles of efficacy, specificity and toxicity and led to the identification of one hydroxamate inhibitor and one protein inhibitor, which were very efficient, non-toxic and very specific of BMP-1. The keratocyte secretome was shown to be a suitable model for the study of BMP-1 activities in the corneal context. More than 2022 proteins were identified, including the BMP-1 metalloprotease and 16 of its 33 already known substrates. Finally, 76 proteins modified by BMP-1 activity were identified in the keratocyte secretome. These results confirm the strong links between BMP-1, extracellular matrix assembly and TGF-beta, but also suggest new roles for this protease in cell proliferation and inflammation. Some of the newly identified substrates (TGFBI, HSP47 and collagen VI) are highly relevant in the context of corneal healing and were validated at the biochemical standpoint. In conclusion, BMP-1 is confirmed as a potential target to treat or prevent the formation of corneal opacities and the characterization of available inhibitors opens up important perspectives for preclinical studies in animals
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Jiang, Yanjie. "Approaches for Improved Positional Proteomics." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/td/1715.

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Positional proteomics is emerging as an attractive technique to characterize protein termini, which play important biological roles in cells. Even with the advances in past decades, there still are areas for improvement. This thesis focuses on improving data quality and assignment confidence in positional proteomics. A novel workflow was designed for the large-scale identification of protein N-terminal sequences. 4-sulfophenyl isothiocyanate (SPITC) is used for N-termini sulfonation; Upon higher energy collisional dissociation (HCD), SPITC peptides in electrospray ionization ESI generate predominately y-type ion series; such simplification of spectra enables the identification of N-termini with high fidelity. The presence of b1 + SPITC product ions upon HCD furthers the confidence for N-terminal identifications. Secondly, sulfonated N-terminal peptides possess one negative charge site at low pH, which was exploited to enrich the SPITC modified N-terminal peptides by electrostatic repulsion hydrophilic interaction (ERLIC) chromatography. Such enrichment process allows both N-termini enriched and N-termini deficient fractions to be collected and analyzed by LC-MS/MS. This method was applied to an E. coli cell lysate, identifying approximately 350 N-terminal peptides (85% represented neo-N-termini from protein degradation and 15% from leading methionine excision). These N-terminal peptides represented 274 distinct E.coli proteins, 224 of which were also identified in the analysis of flow-through fractions from internal peptides. Another approach we took to boost the identification confidence is by exploiting iTRAQ (isobaric tag for relative and absolute quantitation) in the positional proteomics workflow. This approach allows for multiplexed comparison between different samples, and thus is well-suited for degradadomics analyses where degraded samples are compared to control samples. Both control and protease treated sample are labeled by different tags which allows direct comparison of protein N-termini with neo-N-termini. In addition, samples are analyzed duplicate by labeling with two tags, aiming for quick validation of peptides by internal replicates. In this study, Asp-N digested E.coli cell lysate is taken as a model system. A total of 500 N-terminal peptides, corresponding to 370 proteins, were identified with high confidence in one experiment, with 87% of those proteolytic products matching the expected protease digestion specificity, validating the assignment accuracy of this approach.
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Schenck, Craig A. "Using Quantitative Proteomics to Study the Early Events of Gravitropism." Ohio University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1338380163.

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Burg, Dominic William Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Cold adaptation in the Antarctic archeaon Methanococcoides burtonii: the role of the hydrophobic proteome and variations in cellular morphology." Awarded by:University of New South Wales. Biotechnology & Biomolecular Sciences, 2009. http://handle.unsw.edu.au/1959.4/44761.

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Very little is known about the hydrophobic proteins of psychrophiles and their roles in cold adaptation. In light of this situation, methods were developed to analyse the hydrophobic proteome (HPP) of the model psychrophilic archaeon Methanococcoides burtonii. Central to this analysis was a novel differential solubility fractionation procedure, which resulted in a significant increase in the efficiency of resolving the HPP. Over 50% of the detected proteins were not identified in previous whole cell extract analyses, and these underwent an intensive manual annotation process producing high quality functional assignments. Utilising the functional assignments, biological context analysis of the HPP was performed, revealing novel and often unique biology. The analysis acted as a platform for differential proteomics of the organism???s response to both temperature and substrate using stable isotope labelling. The results of which revealed that low temperature growth was associated with an increase in the abundance of surface and secreted proteins, and translation apparatus. Conversely, growth at a higher temperature was associated with an increase in the abundance of general protein folding machinery and indications of an oxidative stress response, emphasising that the temperature for maximum growth rate is stressful. Through investigation of the response of M. burtonii to substrate it was found that growth on methanol was stressful, and its low energy yield resulted in an increase in the abundance of energy conserving systems. The extracellular polymeric substance (EPS) and morphology of M. burtonii was also investigated with respect to both temperature and substrate, using a number of techniques in microscopy. It was found that the EPS was comprised of proteins, sugars and RNA, and that growth at different temperatures resulted in the production of EPS that displayed significantly different properties on dehydration, thus indicating compositional variation. When cells were grown on methanol they took on highly irregular shapes and had electron transparent inclusions. The observations from the ultrastructural analysis were contemplated with respect to the proteomic findings, revealing novel avenues of research. This study has highlighted the roles of hydrophobic proteins in cold adaptation biology, and the value of comprehensive proteomics for the examination of adaptation in microorganisms
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Paula, Leonardo Barcelos de. "Análise proteômica das diversas fases de diferenciação osteoblástica de células-tronco mesenquimais de medula óssea." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-26012011-101120/.

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O crescimento, desenvolvimento e manutenção do tecido ósseo são processos altamente regulados. Diversas proteínas como hormônios, fatores de crescimento e citocinas estão envolvidas nestes processos e exercem atividade direta sobre células osteoblástica e osteoclástica, atuando em sua diferenciação e ativação metabólica. O processo de regeneração óssea é iniciado por fatores estimuladores locais como as proteínas morfogenética óssea (BMP Bone Morphogenetic Proteins). As BMPs são um produto do metabolismo dos osteoblastos, odontoblastos e de várias células tumorais, sendo armazenadas na forma de concentrados no osso, dentina e em células neoplásicas do osteossarcoma e de certos tumores odontogênicos, tais como: fibroma cementificante, cementoblastoma benigno, dentinoma, fibroma odontogênico e odontoma. Esclarecer os mecanismos que controlam a remodelação óssea é uma questão bastante relevante. Nesse sentido, as células-tronco mesenquimais têm despertado grande interesse devido ao seu potencial envolvimento no processo de reparo tissular. A obtenção de osteoblastos funcionais a partir de células-tronco mesenquimais tem sido utilizada na engenharia de tecidos e terapia celular. Desse modo, no presente trabalho foi realizada uma análise proteômica das proteínas envolvidas nas diversas fases de diferenciação osteoblástica de células-tronco mesenquimais de medula óssea de rato Wistar e humana, no sentido de obter maiores informações sobre a diferenciação celular e a biologia do tecido ósseo. Células-tronco mesenquimais obtidas de medula óssea foram cultivadas em meio osteogênico por diferentes períodos para obter células em diversas fases da diferenciação osteoblástica. Para análise proteômica foram utilizadas ferramentas como a estratégia de shotgun proteomics e quantificação relativa (iTRAQ - Isobaric Tag for Relative and Absolute Quantitation) para separação de proteínas e a espectrometria de massas para a identificação e quantificação relativa de proteínas e peptídeos. Neste contexto, os nossos resultados nos levam a concluir que: as CTMs de medula óssea de rato Wistar expressam genes que estão envolvidos na diferenciação osteogênica quando estimuladas in vitro formando matriz óssea no período de 14 dias, ou seja, o fator estimulante no microambiente é de fundamental importância; as CTMs de medula óssea humana apresentaram resultados semelhantes com as CTMs de ratos em nível genômico durante a diferenciação osteogênica, entretanto quando estimuladas in vitro formaram a matriz óssea no período de 21 dias; utilizando duas abordagens proteômicas, foi possível identificar proteínas importantes que estão envolvidas no processo de diferenciação. Mas cabe salientar que, embora tenham sido detectados genes que parecem envolvidos no processo de diferenciação, isso não teve reflexo no proteoma dessas células nos períodos de 7 e 14 dias da indução de diferenciação à osteogênese, o que indica que a maior parte da funcionalidade dessas células quanto aos outros processos biológicos estão preservados, como por exemplo a proliferação celular permaneceu sem grandes alterações. Isso indica que manipulações de isolamento, cultivo e indução da diferenciação dessas células não afetaram o proteoma, com aspectos positivos para a utilização de células-tronco mesenquimais em terapia celular. Do ponto de vista metodológico, esse trabalho abre perspectivas da utilização de estratégias proteômicas baseadas na marcação por isóbaros em combinação com separação de proteínas por eletroforese unidimensional SDS-PAGE para a análise de amostras biologicamente complexas e de quantidades limitadas de obtenção como células-tronco mesenquimais. O estudo da expressão de proteínas durante as fases de diferenciação osteoblástica de células-tronco mesenquimais de medula óssea deve refletir seu estado funcional e contribuir para o entendimento das diversas vias envolvidas no processo de diferenciação.
The growth, development and maintenance of bone tissue are highly regulated processes. Several proteins such as hormones, growth factors and cytokines are actively involved in these processes and exert direct activity on osteoblastic and osteoclastic cells, acting in their differentiation and metabolic activation. The process of bone regeneration is initiated by local stimulating factors as bone morphogenetic proteins (BMP). BMPs are a product of the metabolism of osteoblasts, odontoblasts and various tumor cells and is stored in the form of concentrates in bone, dentin and neoplastic cells of osteosarcoma and certain odontogenic tumors such as fibroma cementifying, cementoblastoma benign dentinoma, odontogenic fibroma and odontoma. Clarify the mechanisms that control bone remodeling is a very relevant issue. Accordingly, the mesenchymal stem cells have attracted great interest because of its potential involvement in the process of tissue repair. Obtaining functional osteoblasts from mesenchymal stem cells has been used in tissue engineering and cell therapy. Thus, this present work performed a proteomic analysis of proteins involved in various stages of osteoblast differentiation of mesenchymal stem cells from bone marrow of Wistar rat and human, in order to obtain more information on the biology of cell differentiation and bone tissue. Mesenchymal stem cells obtained from bone marrow were cultured in osteogenic medium for different periods to obtain cells at different stages of osteoblast differentiation. For proteomics analysis tools were used as the strategy of shotgun proteomics and relative quantification (iTRAQ - isobaric Tag for Relative and Absolute quantitation) for protein separation and mass spectrometry to identify proteins. In this context, our results take us to conclude that the MSCs of Wistar rat bone marrow express genes that are involved in osteogenic differentiation in vitro when stimulated to form bone matrix during the 14 days, ie stimulating factor in the microenvironment is of fundamental importance, the MSCs from human bone marrow showed similar results with rat MSCs at the genomic level during osteogenic differentiation, however, when stimulated in vitro formed bone matrix within 21 days, using two proteomic approaches, we could identify proteins important that are involved in the process of differentiation. But it should be noted that although it has been identified genes that seem involved in the process of differentiation, it was not reflected in the proteome of these cells at 7 and 14 days after induction of the osteogenic differentiation, indicating that most of the functionality of these cells and other biological processes are preserved, such as cell proliferation remained without major changes. This indicates that manipulations of isolation, culture and induction of differentiation of these cells did not affect the proteome, with positive aspects to the use of mesenchymal stem cells in cell therapy. From the methodological point of view, this work opens up the use of proteomic strategies based on the score for isobars in combination with protein separation by electrophoresis, one-dimensional SDS-PAGE for the analysis of complex biological samples and limited quantities of production as mesenchymal stem cells. The study of protein expression during stages of osteoblast differentiation of mesenchymal stem cells from bone marrow should reflect their functional status and contribute to the understanding of pathways involved in the process of differentiation.
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McQueen, Peter. "Alternative strategies for proteomic analysis and relative protein quantitation." Wiley-VCH, 2015. http://hdl.handle.net/1993/30850.

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The main approach to studying the proteome is a technique called data dependent acquisition (DDA). In DDA, peptides are analyzed by mass spectrometry to determine the protein composition of a biological isolate. However, DDA is limited in its ability to analyze the proteome, in that it only selects the most abundant ions for analysis, and different protein identifications can result even if the same sample is analyzed multiple times in succession. Data independent acquisition (DIA) is a newly developed method that should be able to solve these limitations and improve our ability to analyze the proteome. We used an implementation of DIA (SWATH) to perform relative protein quantitation in the model bacterial system, Clostridium stercorarium, using two different carbohydrate sources, and found that it was able to provide precise quantitation of proteins and was overall more consistent in its ability to identify components of the proteome than DDA. Relative quantitation of proteins is an important method that can determine which proteins are important to a biochemical process of interest. How we determine which proteins are differentially regulated between different conditions is an important question in proteomic analysis. We developed a new approach to analyzing differential protein expression using variation between biological replicates to determine which proteins are being differentially regulated between two conditions. This analysis showed that a large proportion of proteins identified by quantitative proteomic analysis can be differentially regulated and that these proteins are in fact related to biological processes. Analyzing changes in protein expression is a useful tool that can pinpoint many key processes in biological systems. However, these techniques fail to take into account that enzyme activity is regulated by other factors than controlling their level of expression. Activity based protein profiling (ABPP) is a method that can determine the activity state of an enzyme in whole cell proteomes. We found that enzyme activity can change in response to a number of different conditions and that these changes do not always correspond with compositional changes. Mass spectrometry techniques were also used to identify serine hydrolases and characterize their expression in this organism.
February 2016
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Books on the topic "ITRAX"

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United States. Internal Revenue Service. Long-term taxable travel income tax reimbursement allowance (ITRA) package. [Washington, D.C.?]: Dept. of the Treasury, Internal Revenue Service, 2002.

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Service, United States Internal Revenue. Long-term taxable travel income tax reimbursement allowance (ITRA) package. [Washington, D.C.?]: Dept. of the Treasury, Internal Revenue Service, 2002.

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Service, United States Internal Revenue. Long-term taxable travel income tax reimbursement allowance (ITRA) package. [Washington, D.C.?]: Dept. of the Treasury, Internal Revenue Service, 2002.

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Bayān al-Qurʼān wa-al-itrah fī asrār al-ḥajj wa-al-ʻumrah. 2nd ed. Qum: Dār al-Thaqalayn, 1999.

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Roshenroz, Liʼor ben Nisan. Sefer Itra ḳadisha: Halakhot ṿe-hanhagot be-vet ha-ḳevarot ; ṿe-nilveh elaṿ be-sofo 2 ḳunṭresim: 1) Ṭohorat anashim ... 2) Shaʻare demaʻot. Bene Baraḳ: [Liʼor Roshenroz], 2008.

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Eye of Itral PF. Frog God Games, 2021.

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Combalia, Victoria. La Itra/L'altra/The Other Britania. TeclaSala, 2001.

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Book chapters on the topic "ITRAX"

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Jarvis, Stuart, Ian W. Croudace, and R. Guy Rothwell. "Parameter Optimisation for the ITRAX Core Scanner." In Micro-XRF Studies of Sediment Cores, 535–62. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-9849-5_22.

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Croudace, Ian W., and R. Guy Rothwell. "ItraxPlot: An Intuitive Flexible Program for Rapidly Visualising Itrax Data." In Micro-XRF Studies of Sediment Cores, 613–24. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-9849-5_26.

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Francus, Pierre, Kinuyo Kanamaru, and David Fortin. "Standardization and Calibration of X-Radiographs Acquired with the ITRAX Core Scanner." In Micro-XRF Studies of Sediment Cores, 491–505. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-9849-5_20.

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Rodríguez-Germade, Isabel, Belén Rubio, Daniel Rey, Federico Vilas, Carmen F. López-Rodríguez, Maria Carmen Comas, and Francisca Martínez-Ruiz. "Optimization of Itrax Core Scanner Measurement Conditions for Sediments from Submarine Mud Volcanoes." In Micro-XRF Studies of Sediment Cores, 103–26. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-9849-5_3.

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Hunt, James E., Ian W. Croudace, and Suzanne E. MacLachlan. "Use of Calibrated ITRAX XRF Data in Determining Turbidite Geochemistry and Provenance in Agadir Basin, Northwest African Passive Margin." In Micro-XRF Studies of Sediment Cores, 127–46. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-9849-5_4.

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Gadd, P., H. Heijnis, C. Chagué-Goff, A. Zawadzki, D. Fierro, P. Atahan, Ian W. Croudace, and J. Goralewski. "ITRAX Core Scanner Capabilities Combined with Other Geochemical and Radiochemical Techniques to Evaluate Environmental Changes in a Local Catchment, South Sydney, NSW, Australia." In Micro-XRF Studies of Sediment Cores, 443–55. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-9849-5_17.

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Jones, Alexandra M. E., and Thomas S. Nühse. "Phosphoproteomics Using iTRAQ." In Methods in Molecular Biology, 287–302. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-264-9_17.

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Vaudel, Marc, Julia Maria Burkhart, René Peiman Zahedi, Lennart Martens, and Albert Sickmann. "iTRAQ Data Interpretation." In Methods in Molecular Biology, 501–9. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-885-6_30.

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Dagan, Aviv, and Eliezer Dekel. "ITRA under Partitions." In Next Generation Information Technologies and Systems, 97–108. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-04941-5_12.

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Liu, Tong, Jun Hu, and Hong Li. "iTRAQ-Based Shotgun Neuroproteomics." In Methods in Molecular Biology, 201–16. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-562-6_14.

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Conference papers on the topic "ITRAX"

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Morgan, Stephen P., Ricardo Correia, Sergiy Korposh, Mohammed Al-Badri, Barrie R. Hayes-Gill, Andrew M. Norris, Rishie Sinha, Jonathan G. Hardman, David S. Gardner, and Simon Talbot. "Development and Translation of intra-Tracheal Multiplexed Sensing Endotracheal Tubes (iTraXS)." In Clinical and Translational Biophotonics. Washington, D.C.: OSA, 2020. http://dx.doi.org/10.1364/translational.2020.ttu2b.6.

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Wright, Mark, and Matthew Peter Maisey. "The use of the ITraC test to characterise main charge materials." In SHOCK COMPRESSION OF CONDENSED MATTER - 2011: Proceedings of the Conference of the American Physical Society Topical Group on Shock Compression of Condensed Matter. AIP, 2012. http://dx.doi.org/10.1063/1.3686368.

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Yang, Heng-Yi, and Tian-Ni Mao. "ITGAX: A Potential Biomarker of Acute Myeloid Leukemia (AML) through Bioinformatic Analysis." In 2021 IEEE 9th International Conference on Bioinformatics and Computational Biology (ICBCB). IEEE, 2021. http://dx.doi.org/10.1109/icbcb52223.2021.9459204.

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Meiqun, Cao, Gui Zifan, Sun Kehuan, and Wu Zhengzhi. "Application of iTRAQ quantitative proteomics in identification of serum biomarkers in breast cancer." In 2011 4th International Conference on Biomedical Engineering and Informatics. IEEE, 2011. http://dx.doi.org/10.1109/bmei.2011.6098563.

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Das, Arunangshu, John Richie, James Bortner, Cesar Aliaga, Anne Stanley, Bruce A. Stanley, and Karam El-Bayoumy. "Abstract 4589: Changes in proteomic profiles with age in male rats using the iTRAQ approach." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4589.

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Bortner, James D., John Richie, Arunangshu Das, Jason Liao, Todd Umstead, Anne Stanley, Bruce Stanley, Chandra Belani, and Karam El-Bayoumy. "Abstract 4572: Comparison of proteomic profiles in human plasma of smokers and nonsmokers using the iTRAQ approach." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4572.

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Li, Xiu-Min. "Abstract LB-7: The high-risk subject screening of ESCC by iTRAQ-coupled 2D LC-MS/MS." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-lb-7.

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Kamau, Gabriel, James Njihia, and Agnes Wausi. "E-government websites user experience from public value perspective: Case study of iTax website in Kenya." In 2016 IST-Africa Week Conference. IEEE, 2016. http://dx.doi.org/10.1109/istafrica.2016.7530631.

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Wang, Jinxue, and Gail P. Anderson. "Validation of FASCOD3 and MODTRAN3: comparison of model calculations with interferometer observations from SPECTRE and ITRA." In Satellite Remote Sensing, edited by David K. Lynch. SPIE, 1994. http://dx.doi.org/10.1117/12.196698.

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Calderon, Enrique J., Vicente Friaza, Jose Martin-Juan, Ruben Morilla, Sonia Gutierrez-Rivero, Jose M. Varela, Nieves Respaldiza, Francisco J. Medrano, and Carmen de la Horra. "Identification Of Differentially Expressed Proteins In Bronchoalveolar Lavage Fluid Of Individuals Colonized By Pneumocystis Jirovecii Using Itraq Mass Tagging." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4143.

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Reports on the topic "ITRAX"

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Pibida, L., R. Minniti, M. O'Brien, and L. Lucas. Test Report - Exposure and Ambient Dose Equivalent Rate Measurements in Support of the ITRAP+10 Testing. National Institute of Standards and Technology, May 2013. http://dx.doi.org/10.6028/nist.tn.1800.

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