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Schoffer, Pavel. "Analýza informačního systému ISAD a návrh jeho změn." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-241506.
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This diploma thesis focuses on the information system ISAD owned by ISIT a.c. Primary part of the project is composed of analysis of the system and used technologies. Another part is concentrated on integration of the system for given customer and possibilities of enhancement. Project also contains proposals of new and enhancements of current functionality of the system.
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Casini, Paola. "ISAD(G) : synthesis or innovation in archival description traditions." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446836/.
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Over the past years the International Council on Archives (ICA) has developed the "International Standards for Archival Description" ISAD(G). The last draft of the ISAD(G) was adopted by the ICA in 1993 and was revised at the 14th International Congress on Archives held in Seville, in September 2000. However, at present the ISAD(G) is not yet well known and not often used in countries with strong national archival traditions. After giving an overview on traditional definitions of archival description, my research analyses the current implementation of the ISAD(G) in North America, in some European countries and in the institutions of the European Union. The application of ISAD(G) with its innovative key-elements represents a starting-point for future developments of archival description in the international debate among archivists. This research deals also with the difficult implementation of these standards in databases through the examination of several case studies. It also looks at the impact of electronic records on traditional archival theory and on archival description techniques. The thesis analyses the impact of the Internet on archival theory and practice, and looks at the Internet's challenge to access policies through the replacement of traditional finding aids. In the conclusions the thesis analyses the ICA's revision of the "International Standard Archival Authority Record (Corporate Bodies, Persons and Families)", ISAAR(CPF), in its relationship to the implementation of ISAD(G) in view of possible outcomes for future techniques of archival description, and makes proposals for future research.
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Pip, Stefanie [Verfasser], and Robert [Akademischer Betreuer] Rödl. "Intramedulläre Beinverlängerung mit dem ISKD® / Stefanie Pip ; Betreuer: Robert Rödl." Münster : Universitäts- und Landesbibliothek Münster, 2014. http://d-nb.info/1138281956/34.
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Jones, Iona Mahima. "Unfinished business : the development of racial(ised) identity in people of mixed parentage." Thesis, University of Warwick, 1999. http://wrap.warwick.ac.uk/50770/.
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In a society concerned with 'racial' purity and anxious to protect 'racial' boundaries people of mixed parentage are presumed to experience pressure, internal and external, to be aware of 'racial' differences and their own perceived ambiguous position. Some commentators believe that people of mixed parentage 'do not fit' into society If only they would pretend to be 'like the rest of us' then everyone would be happy There are few, if any, representations of coherent identities. The main concern of my research is to discover the factors which influence the development of racial(ised) identity in people of mixed parentage. An understanding of personal and social identity is an important part of my research I investigate how people of mixed parentage express their racial(ised) identity and question whether racial(ised) identity formation is ever really finished.
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Chaves, Elisa Maria Lopes. "Descrição arquivística de documentos fotográficos em sistemas informatizados." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/27/27163/tde-26022019-170852/.
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Nas instituições arquivísticas, as imagens estão cada vez mais acessíveis através da web. A pesquisa analisa a descrição dos documentos fotográficos digitais neste contexto, sejam eles produtos da digitalização da imagem física, isto é, produzida em processos analógicos, ou das imagens nato-digitais. Visa analisar o acesso em ambientes virtuais, através da padronização das normas de descrição arquivística. Para isso, foi utilizado o AtoM, software desenvolvido pelo Conselho Internacional de Arquivo (CIA), ferramenta totalmente voltada para web, que segue padrões de normas arquivísticas como a ISAD(G). Com o objetivo de complementar as especificidades do documento fotográfico, analisamos a ferramenta Sepiades, desenvolvida pelo CIA para descrever coleções fotográficas, atendendo às normas arquivísticas. Através da análise das duas ferramentas, realizada por meio de pesquisa bibliográfica e documental, verificamos que o AtoM é a ferramenta mais indicada para a descrição dos documentos. Como resultado, geramos um quadro para descrição de documentos fotográficos arquivísticos com base no AtoM, compatibilizado com os parâmetros do modelo Sepiades.In archival institutions, images are increasingly accessible through the web. The research analyzes the description of digital photographic documents in this context, whether they are products of physical image scanning, that is, produced in analogical processes, or of digital-born images. It aims to analyze access in virtual environments, through the standardization of the norms of archival description. For this purpose, AtoM was used, software developed by the International Archive Council (CIA), a web-based tool that follows the standards of archival standards such as ISAD(G). In order to complement the specificities of the photographic document, we analyzed the Sepiades tool, developed by the CIA to describe photographic collections, meeting archival standards. Through the analysis of the two tools, carried out through bibliographical and documentary research, we verified that the AtoM is the most suitable tool for the description of the documents. As a result, we generated a framework for describing archival photographic documents based on AtoM, compatible with the parameters of the Sepiades model
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Madsen, Sabine. "Emerging methods : an interpretive study of ISD methods in practice /." København, 2004. http://www.gbv.de/dms/zbw/476259614.pdf.
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Souto, Diana Vilas Boas. "A aplicação do modelo RDF na descrição arquivística : em foco a Norma ISAD(G)." Universidade Estadual de Londrina. Centro de Educação, Comunicação e Artes. Programa de Pós-Graduação em Ciência da Informação, 2014. http://www.bibliotecadigital.uel.br/document/?code=vtls000194630.
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O advento das novas tecnologias e suas aplicações no campo arquivístico, traz à tona recentes esforços em direção a organização da informação. É de conhecimento a importância das normas que orientam a descrição dos documentos de arquivos, já que estas garantem uma uniformidade no processo. Entretanto, para que as normas possam cumprir seu papel, é fundamental que estas busquem auxílio as tecnologias disponíveis, de modo a ampliar sua atuação na web. Desta forma, insere-se neste contexto a Web Semântica como cooperadora nesta ação, uma vez que assegura que os dados descritos por meio do modelo Resource Description Framework (RDF) possam ser organizados, recuperados e relacionados entre si, realizando inferências entre os dados recuperados Assim, este estudo explora a atuação do modelo RDF proposto pelo World Wide Web Consortium (W3C), tendo como foco os elementos que compõem a Norma Geral Internacional de Descrição Arquivística [ISAD(G)]. Partindo desta condição, propõem-se um perfil de aplicação que faz uso de elementos de metadados dos padrões Dublin Core (DC) e Encoded Archival Description (EAD) com conformidade com a Norma ISAD (G), visando a descrição nos moldes do modelo RDF. Numa abordagem qualitativa, realizou-se uma pesquisa exploratória, bibliográfica e documental. Como resultado, elaborou-se um diagrama de atividade em Unified Modelling Language (UML) de forma a representar a modelagem conceitual do perfil e a atuação do modelo RDF neste processo. Conforme o objeto central da pesquisa, elaborou-se o Joá Archival Description Application Profile (JADAP), um perfil que auxilie na organização das informações arquivísticas existentes hoje na web, o qual descreve unidades arquivísticas em partes, estruturando as informações e relacionando-as outras informações presentes em outras bases de dados através inferências, tendo como objeto um vocabulário próprio comum. Este estudo adota o modelo RDF para a descrição arquivística. Esta investigação se fez necessária, a fim de corroborar com a organização e a recuperação das informações arquivísticas disponíveis hoje na web, e de modo particular, que orientam o campo de pesquisa voltado a Ciência da Informação (CI) e a Arquivística, de maneira a ampliar o diálogo entre estas e o universo da Web Semântica.The advent of new technologies and their applications in the archival field brings up recent efforts toward organizing information. It is well known the importance of standards to guide the description of archival documents, as these ensure uniformity in the process. However, in order to standards fulfill their role, it is essential that they seek help in available technologies in order to expand its operations on the web. Thus, the Semantic Web is inserted in this context as a cooperator in this action, since it ensures that the data described by the Resource Description Framework (RDF) model can be organized, retrieved, and related to each other, making inferences from the data retrieved. This study explores the role of the RDF model proposed by the World Wide Web Consortium (W3C), focusing on the elements that make up the General International Standard Archival Description [ISAD (G)]. Based on this condition, we propose an application profile that makes use of metadata elements of Dublin Core (DC) and Encoded Archival Description (EAD) standards with compliance with ISAD (G) Standard, to the description in the mold of RDF model. In a qualitative approach, we performed an exploratory, literature and documentary research. As a result, an activity diagram in Unified Modelling Language (UML) was developed to represent the conceptual modeling of the profile and the performance of the RDF model in this process. According to the central object of the research, we developed the Joá Archival Description Application Profile (JADAP), a profile that assists in the organization of existing archival information on the web today, which describes archival units in parts, structuring information and relating them to other information present in other databases through inferences, having as purpose a common vocabulary. This study adopts the RDF model for archival description. This research was necessary in order to corroborate the organization and retrieval of archival information available today on the web, and in particular, that guide the search field oriented to Information Science (IS) and Archival Science, in order to enlarge the dialogue between them and the universe of the Semantic Web.
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Kitiyadisai, Krisana. "Concepts of relevance in a semiotic framework applied to ISAD (Information Systems Analysis and Design)." Thesis, London School of Economics and Political Science (University of London), 1991. http://etheses.lse.ac.uk/1127/.
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Relevance is the critical criterion for valuing information. The usual requirements of valuable information resources are their accuracy, brevity, timeliness and rarity. This thesis points out that relevance has to be explicitly recognised as an important quality of information. Therefore, the theory of signs is adopted to enable a systematic study of the problem of relevance according to the branches of semiotics in order to clarify the concept of information. Relevance has several meanings according to the various disciplinary approaches including phenomenology, law, logic, information science, communication and cognition. These different concepts are discussed and criticised in two chapters. A new approach is proposed in which a universal concept of relevance is considered as an affordance. Therefore, all the approaches to relevance can be applied within the broader approach of the analysis of affordances. This approach not only encompasses all the underlying characteristics of relevance, it is also compatible with the assumptions of the logic of norms and affordances (NORMA). NORMA semantic analysis is used as a basis on which concepts of relevance are applied semiotically. Two case- studies are selected for testing these concepts which results in a guideline for practical application in a semiotic framework. The results from these case-studies confirm the practical importance of these concepts of relevance which can be systematically used in the analysis and design of information systems. It also reaffirms the underlying characteristics of relevance which exist in the context of social reality.
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Karlsson, Kristin. "S-Kalcidiol : En metodjämförelse mellan IDS-iSYS och Cobas E801 vid analys av S-Kalcidiol." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-105003.
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Vitamin D är den sammanlagda koncentrationen för metaboliterna vitamin D2 och vitamin D3 och är en tillförlitlig indikator gällande vitamin D-statusen i kroppen. Den huvudsakliga källan till vitamin D är bildandet av metaboliten vitamin D3 i huden med hjälp av ultraviolett B-ljus och vitaminet har bland annat en viktig roll för skelettets utveckling. Koncentrationen kalcidiol (25(OH) vitamin D) kan bestämmas till exempel med hjälp av elektrokemiluminiscens med kompetitiv inbindning. Mätprincipen har flera likheter med kemiluminiscens med den huvudsakliga skillnaden att elektrisk spänning används för att starta reaktionen. När en analys ska flyttas från ett instrument till ett annat är det viktigt att verifiera att de är överensstämmande gällande bland annat precision. Syftet med projektet var att genomföra en metodjämförelse för analys av kalcidiol i serum (S-Kalcidiol) mellan instrumenten IDS-iSYS och Cobas E801 samt att genomföra en jämförelse av kontroller från företagen Roche Diagnostics och ThermoFisher Scientific och utifrån de erhållna resultaten avgöra vilka som var mest lämpliga att använda vid analys med Cobas E801. Kontrollerna från Roche Diagnostics är optimerade för analysen, men det vore fördelaktigt att kunna använda kontrollerna från ThermoFisher Scientific eftersom de även kan användas för flera andra analyser. Metodjämförelsen gjordes med hjälp av en inomserie- och totalimprecisionsstudie med en låg och en hög kontrollnivå från företagen Roche Diagnostics och ThermoFisher Scientific samt en korrelationsstudie med 20 stycken patientprover bestående av serum. Inomserie- och totalimprecisionen resulterade i att Cobas E801 hade likvärdig precision med IDS-iSYS. Gällande kontrollerna var endast kontrollerna från Roche Diagnostics inom acceptansintervallen och är därmed lämpligast att använda. Korrelationsstudien resulterade i determinationskoefficienten 0,942, vilket tyder på ett tydligt linjärt samband. Studien visar dock att Cobas E801 har en större spridning när koncentrationen kalcidiol överstiger 50 nmol/L. Utifrån de erhållna resultaten kan en flytt av analysen från IDS-iSYS till Cobas E801 genomföras för att effektivisera arbetsflödet.
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Camp, Devernay Sophie. "Comportement sous flexion d'une argile : application à la couverture d'une ISD TFA." Grenoble 1, 2008. http://www.theses.fr/2008GRE10256.
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La barrière imperméable de couverture de l’Installation de Stockage de Déchets très faiblement radioactifs (ISD TFA) étudiée est composée d’une couche d’argile et d’une géomembrane. Ce concept de stockage de surface est comparable à une ISD dangereux (classe 1). L’argile de couverture d’une ISD doit conserver ses propriétés, notamment sa perméabilité doit rester inférieure à dix puissance moins neuf mètre par seconde, durant toute la période de suivi du site et ceci malgré les sollicitations qui peuvent engendrer de la fissuration. Parmi ces sollicitations, les tassements différentiels des déchets sous-jacents, engendrant de la flexion, sont une des sollicitations les plus critiques envisageables. La réglementation actuelle concernant la mise en œuvre en couverture d’une couche d’argile présente des lacunes, notamment en ce qui concerne la prise en compte de la déformabilité de l’argile. L’étude présentée a pour intérêt de coupler des essais de laboratoire (essais de flexion 4 points et essais de traction indirecte par fendage et par poinçonnement) à des planches d’essais de flexion in situ réalisées en grandeur réelle et à leur modélisation en centrifugeuse. Ces essais ont également été modélisés numériquement par éléments finis. On montre une bonne compatibilité des résultats notamment en ce qui concerne la définition des conditions d’initiation de la fissure par flexion ce qui a permis d’étendre l’étude à des cas non traités in situ (modélisation numérique d’essais de tassement, étude du renforcement de l’argile en centrifugeuse)The sealing cover system of landfills for storing non bio-degradable and dangerous waste is most of the time made up of a layer of clay and/or a geomembrane. The question of the optimization of the conditions of storage of the radioactive waste envisage a surface storage for very low level radioactive waste (VLLW) and low and intermediate short-lived radioactive waste. This study is applied to a VLLW disposal facility of which the cover is made up of a clay layer over a geomembrane but can be transposed to landfill for dangerous waste. The cover clay barrier of a landfill must preserve its properties; in particular its permeability must remain inferior to ten to the minus nine meters per second, during the life of the landfill in spite of the various solicitations which can generate cracking. Among these solicitations, the relative settlements of subjacent waste, generating bending solicitation, are one of the most critical solicitations. The current regulation concerning the implementation as a cover of a clay layer presents gaps, in particular with regard to the deformability of clay. This study presents the interest to couple laboratory tests (four points bending tests, splitting test and punching test) with field bending tests carried out at scale one and with their modeling with centrifugal tests. These tests were also numerically modeled by finite elements. A good compatibility of the results, in particular with regard to the definition of the conditions of initiation of the crack by bending, is shown. Numerical modeling and centrifugal tests made it possible to extend the study to unperformed in situ cases (settlement tests, reinforcement of the clay)
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Šindelář, Jiří. "Plánování cesty neholonomního mobilního robotu." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2010. http://www.nusl.cz/ntk/nusl-229001.
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This thesis deals with robot path planning by means of selected methods. Specifically by the methods RRT, IGPPR and ISSD. The theoretical part contains the overview of existing methods for path planning and description of previously mentioned methods. The practical part describes implementation of each methods which are applied to nonholonomic mobile robot working in 2D workspace with static obstacles.
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Nörnberg, Antje [Verfasser], and Markus [Akademischer Betreuer] Fischer. "Non-Mevalonatbiosynthese : Identifizierung und Charakterisierung von Hemmstoffen gegen IspD aus Plasmodium vivax / Antje Nörnberg ; Betreuer: Markus Fischer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2018. http://d-nb.info/1153884240/34.
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Santos, Fernando Antonio Fragoso dos. "O professor de língua inglesa no audiolingual: uma abordagem sociointeracionista acerca dos textos sobre o trabalho docente." Universidade Federal da Paraíba, 2011. http://tede.biblioteca.ufpb.br:8080/handle/tede/6392.
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Our dissertation is included in the Aplied Linguistics and Social Practices Context part of the Post-graduation Program in Linguistics at Universidade Federal da Paraíba, focusing on the representations on teachers actions in work situations. We work with the teaching of the English language performed in a language school located in Joao Pessoa-PB, whose methodology is based on the Audiolingual Method. We believe that if such method prescribes the teacher s actions, it is also a way to make this teacher reflect about his/her practice highlighting points of views and changes. Our theoretical perspective shares the studies developed by the Socio and Discursive Interactionism (SDI) approach whose main reference is Bronckart (1997 e ss.) and the other researchers. Our focus is to identify and analyze the relation between language and educational work in texts produced before and after the work situation. Behind such perspective, we present our main goal that is to understand the way such texts reflect representations, interpretations and social evaluations concerning the teacher s activity. We used the action categories developed by Bronckart and Machado (2004) and Bulea (2010) to analyze the texts before and after the teacher s work. In a first moment, we identified such categories in a prescriptive document previously implicated in the classroom context, considering the roles attributed to the teachers. After that, we verified the actions mobilized by the teachers throughout their interviews and the roles they assign themselves. We believe that this research represents a relevant contribution to reflect about the way prescriptive documents really influence the teaching practice and the way teachers usually deal with such prescriptions.
Nosso trabalho acadêmico se insere no contexto de pesquisas em Lingüística Aplicada e Práticas Sociais do Programa de Pós-Graduação em Lingüística da Universidade Federal da Paraíba com foco nas representações do agir docente em situação de trabalho. Trabalhamos com o ensino de língua inglesa em uma escola de idiomas localizada na cidade de João Pessoa PB, parte de um sistema de franquias, cuja metodologia de trabalho se fundamenta, entre outros aspectos, no Método Áudiolingual. Partimos do pressuposto de que o método em questão, ao mesmo tempo em que delimita o trabalho do professor, também o faz repensar sua prática dando margem a posicionamentos e mudanças. Nossa perspectiva teórica compartilha dos estudos realizados no âmbito do Interacionismo SócioDiscursivo (ISD) desenvolvido por Bronckart (1997 e ss.) e demais pesquisadores. O nosso foco de análise volta-se à identificação da relação entre linguagem e trabalho educacional em textos produzidos sobre o trabalho (o Guia de Capacitação) e em situação de trabalho (Entrevistas) e, diante disso, elaboramos o nosso objetivo principal que é o de verificar como tais textos refletem as possíveis representações, interpretações e avaliações sociais da atividade docente. Utilizamos como procedimento analítico, numa perspectiva qualitativa, os elementos linguístico-estruturais com base nas categorias de uma Semântica do Agir propostas por Bronckart e Machado (2004) e Bulea (2010) considerando os textos produzidos anteriormente e posteriormente a situação de trabalho. Em um primeiro instante, identificamos as categorias mencionadas em um documento prescritivo diretamente implicado no trabalho de ensino e anterior a este, considerando, também, os papéis atribuídos aos professores. Posteriormente, nós verificamos as ações mobilizadas pelos professores em suas entrevistas e os papéis que eles mesmos se atribuem. Acreditamos que a nossa pesquisa representa uma contribuição relevante na busca da reflexão acerca da forma como os documentos prescritivos influenciam, de fato, a prática de sala de aula e como os professores se posicionam diante de tais prescrições.
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Shareef, Mohammed Ibrahim, and Aus Wail-Al Rawi. "The Customized Database Fragmentation Technique in Distributed Database Systems : A case Study." Thesis, Tekniska Högskolan, Högskolan i Jönköping, JTH, Data- och elektroteknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-18539.
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In current age, various companies are using a centralized database system for dailybusiness transactions in different domains. Some critical issues have been observedrelated to the complexity, maintenance, performance and communication cost of datain centralized data repository for query processing, according to the demand of endusersfrom different locations. So, different enterprises are striving to implementefficient distributed database systems in their business environments for scalability.The distributed database architecture covers different factors such as transparentmanagement system, replication, fragmentation and allocation etc. This dissertationfocuses on database fragmentation and techniques which are useful for performingdatabase fragmentation. The objective of this research is to investigate efficient algorithm and technique fordatabase fragmentation in distributed environment. We proposed a customized ISUD(Insert, Select, Update, Delete) technique after comparative study of the best suitabletechniques, which is selected for implementation purpose. The functionality of thecustomized ISUD technique helps to get the precedence of the attribute of a relationhorizontally in database from various sites or location. The practical objective of this dissertation is to design the architecture and develop,implement customized ISUD (Insert, Select, Update, Delete) user interface, and to testthe selected algorithm or technique by using the interface. We used C#.Net as adevelopment tool. This user interface accepts ISUD frequency as an input andproduces ALP (attribute location precedence) values as output. We have incorporateddesign science research (DSR) method for customized ISUD technique development.This customized ISUD technique can be considered as a foundation to implementhorizontal database fragmentation in distributed environment, so that the databaseadministrator can take a proper decision for allocating the fragmented data to varioussites at initial state of distributed database design.
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Pye, Matthew James. "Inhibiting Plasmodium falciparum IspD, a MEP pathway enzyme, as a novel target for the development of antimalarial chemotherapeutics." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3020589/.
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Ramalho, Lúcia Ferreira. "O fenómeno da delinquência juvenil na formação de gangues em Portugal: um estudo exploratório do projeto ISRD-3." Bachelor's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5005.
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Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em CriminologiaO estudo intitulado “ O Fenómeno da Delinquência Juvenil na Formação de Gangues em Portugal: um estudo exploratório do projeto ISRD-3” baseia-se num estudo internacional chamado Interntional Self- Reported Delinquency Study , na sua 3ª versão em Portugal (ISRD-3), e tem por objetivo explorar o impacto da delinquência juvenil junto da formação de gangues. No presente projeto, que numa primeira parte, se propõe uma breve revisão da literatura dos contextos relativos aos conceitos Delinquência e Gangues, dos objectivos e bases teóricas do estudo ISRD-3; seguindo-se de uma segunda parte com a apresentação e a exploração dos resultados preliminares do passe piloto realizado na cidade do Porto, propondo-se identificar a existência de normas subculturas e adesão a gangues, segundo os parâmetros da Eurogang; e qual a sua influência, se existir, no comportamento criminal ou violento dos integrantes de gangues em Portugal. Portanto, será correto afirmar que a delinquência um fator chave na formação de gangues em Portugal? The theme " Youth Delinquency Phenomenon in the Formation of Gangs in Portugal: an explotarory study of the project ISRD-3" it’s a part of a larger study of ISRD Project (Self-Reported Delinquency in its 3rd version), that aims to investigate the impact of juvenile delinquency in the formation of gangs. In this project, initially is proposed, through a brief literature review of the contexts of the concepts “delinquency” and “gangs”, followed by a second phase, with the presentation and the exploration of the results achieved with ISRD-3 project, where is intended to identify the existence of subcultures and antisocial norms, and his influence in criminal or violent behavior of gang members in Portugal. So is it true that crime is a key factor in the formation of gangs in Portugal?
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Matz, Kayla Louise Polzin. "The Intricate Balance of Metal Trafficking in Bacteria: Import of Iron in Bacillus anthracis and Export of Excess Copper in Escherichia coli." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/581322.
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Bacterial organisms continuously maintain homeostasis even in changing environments. This ability to maintain homeostasis is especially critical for pathogenic and opportunistic bacteria, which must adapt to both abiotic and biotic host environments. Both types of environments present unique limitations and conditions. Transition metal homeostasis under these varying conditions is important for bacterial survival. Transition metals such as zinc, cobalt, iron and copper are essential for cell survival, but become toxic if in excess. The host organism often takes advantage of this requirement by greatly limiting access to transition metals to limit infections, but in other environments, toxic levels of metal may be present. Bacterial organisms have developed many mechanisms to maintain transition metal homeostasis. This study focuses on two bacterial systems that are utilized to maintain metal balance; the heme-acquiring iron surface determinant (Isd) system of Bacillus anthracis and the copper and silver export Cus system of Escherichia coli. Host organisms use many proteins and systems to limit iron access from pathogenic bacteria, known as nutrient immunity. B. anthracis must acquire iron from the host organism upon infection and so has evolved multiple iron acquisition systems. The Isd system employs two extracellular proteins, IsdX1 and IsdX2, to remove heme from hemoglobin to use as an iron source. Once bound to heme, these hemophores transfer heme to a cell surface attached protein, IsdC, which further relays the molecule to be transferred into the cell for iron use. This study focused on the kinetics of heme transfer to better understand how acquisition occurs. This study determined that the oxidation state of the iron-heme molecule plays a significant role in the kinetics of heme acquisition by IsdX1 and subsequent transfer to IsdC. This work clarifies and further establishes the mechanism of iron acquisition by B. anthracis during infection. Copper and silver are used in many settings as antimicrobial agents, including as an alternative to antibiotic drugs. Pathogenic and opportunistic bacteria, such as E. coli, experience stress upon contact with copper and silver surfaces and materials. Copper is an essential transition metal, while silver is not biologically used, but both become toxic when in excess due to redox properties and disruption of biological molecules. E. coli utilizes several systems to remove excess copper and silver to resist toxicity. The Cus system, consisting of the soluble CusF and tripartite pump CusCBA, specifically exports copper and silver from the periplasm. Several roles of CusF have been suggested from in vitro data. The components CusAB were hypothesized to be the essential proteins of the CusCBA pump, while the outer membrane unit may not contribute specificity or be necessary for export. This study focused on the role and importance of CusF and outer membrane channel CusC during copper stress in vivo. An in vivo interaction between CusF and CusB was identified during copper stress. The data from this work indicate that cusF and cusC directly affect intracellular copper accumulation. Furthermore, this study revealed that SdsP may play in a secondary role to CusC to complement CusC to maintain copper resistance. This works establishes the importance of CusC as the main outer membrane component during copper export in E. coli.
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Barbosa, LÃlian Paula LeitÃo. "Uma visÃo interacionista sociodiscursiva de leitura: por uma proposta interventiva para a aula de leitura no ensino bÃsico." Universidade Federal do CearÃ, 2017. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18488.
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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel SuperiorCette Ãtude a commencà à partir de lâanalyse des derniers rÃsultats des Ãvaluations à large Ãchelle, Spaece et Prova Brasil, appliqueÃs aux ÃlÃves de la derniÃre annÃe de lâenseignement fondamental II, des annÃes de 2009 à 2013, dans lâÃtat du CearÃ, dans laquelle des faibles niveaux de compÃtence en lecture ont Ãtà vÃrifiÃs, en dÃpit dâune amÃlioration significative. Pour changer cette situation de bas rÃsultats dans les diverses Ãvaluations internes et externes qui impliquent la lecture dans lâÃducation de base, il faut Ãlaborer une transposition didactique innovante qui soit capable dâencourager des professeurs aux nouvelles dÃcouvertes et aux nouveaux dÃfis. En raison de cette nÃcessitÃ, on a proposÃ, alors, une intervention dâaprÃs la mÃthodologie de la recherche-action, dÃfinie comme  une recherche associÃe aux diverses faÃons dâaction collective qui est orientÃe vers la rÃsolution de problÃmes ou dâobjectifs de transformation  (THIOLLENT, 2008), en utilisant un modÃle de sÃquence didactique (DOLZ, 2010) pour lâenseignement de la lecture dans lâÃducation basique, particuliÃrement, dans la neuviÃme annÃe de lâenseignement fondamental II. Il sâagit, de cette faÃon, dâune recherche qualitative à propos de la pratique de la lecture en classe et du travail enseignant, dont lâobjectif est lâagir mÃme professionnel de lâenseignant-chercheur. Ce travail a pour but, donc, de faire une analyse de la pratique actuelle de lecture dans lâenseignement basique et de proposer une perspective dâintervention plus actuelle pour rendre ce cours de lecture plus efficace pour lâapprentissage et pour le dÃveloppement de la compÃtence comunicative des ÃlÃves. Pour rÃussir cet objectif, on se base sur les Ãtudes de Braggio (1992), en ce qui concerne la conception socio-historique idÃlogique de langage ; sur le cadre thÃorique de lâInteraccionisme Socio-discursif - ISD - (BRONCKART, 1999) et sur les modÃles de cours de lecture proposÃs par Cicurel (1991) et par Leurquin (2014).
A leitura à o foco principal do nosso trabalho, pois ela tem um lugar de destaque nas prÃticas sociais, jà que Ã, por meio dela, que os indivÃduos se comunicam nos diversos setores da sociedade. Diante da importÃncia da leitura para a formaÃÃo de um leitor crÃtico e social, fica evidente a relevÃncia da escola e do agir professoral do professor de LÃngua Portuguesa LM (LÃngua Materna) no processo de ensino e aprendizagem da leitura. Este estudo, entÃo, proporcionou a anÃlise dos Ãltimos resultados das provas de larga escala, Spaece e Prova Brasil, aplicadas aos alunos do Ãltimo ano do Ensino Fundamental II, dos anos de 2009 a 2013 no estado do CearÃ, em que foram averiguados, apesar de uma melhora significativa, os baixos Ãndices de proficiÃncia em leitura. Para reverter esse quadro de ainda baixos resultados nas diversas avaliaÃÃes internas e externas envolvendo leitura no nÃvel bÃsico de ensino, seria necessÃrio que se elaborasse uma transposiÃÃo didÃtica inovadora, capaz de encorajar professores a novas descobertas e desafios. Verificando essa necessidade, propomos, entÃo, uma intervenÃÃo por meio da metodologia da pesquisa-aÃÃo, âpesquisa associada a diversas formas de aÃÃo coletiva que à orientada em funÃÃo da resoluÃÃo de problemas ou de objetivos de transformaÃÃoâ (THIOLLENT, 2008), utilizando um modelo de sequÃncia didÃtica (DOLZ, 2010), voltada para o ensino da leitura para o nÃvel bÃsico, mais especificamente para o nono ano do Ensino fundamental II. Tratar-se-à de uma pesquisa qualitativa sobre a prÃtica da leitura em sala de aula e do trabalho docente cujo foco serà o prÃprio agir profissional do professor-pesquisador. O objetivo deste trabalho, portanto, à propor uma perspectiva interventiva mais atual para tornar essa aula de leitura mais eficiente para a aprendizagem e para o desenvolvimento da competÃncia comunicativa dos discentes. Para conseguirmos tal objetivo, ancoramo-nos em estudos de Braggio (1992), quanto à concepÃÃo sÃcio-histÃrica ideolÃgica de linguagem, tendo como base o quadro teÃrico do Interacionismo Sociodiscursivo - ISD (BRONCKART, 1999) e os modelos de aulas de leitura propostos por Cicurel (1991) e Leurquin (2014).
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Albuquerque, Ana Cristina de [UNESP]. "Catalogação e descrição de documentos fotográficos em bibliotecas e arquivos: uma aproximação comparativa dos códigos AACR2 e ISAD (G)." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/95536.
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A presente pesquisa aborda o documento fotográfico no âmbito de sua descrição em arquivos e bibliotecas. Tem o objetivo de fazer uma possível comparação entre as normas AACR2, utilizadas para a descrição bibliográfica nas bibliotecas e a norma ISAD (G) que, por sua vez, é o conjunto de regras para que seja obtida a descrição arquivística. Para tanto, parte-se do conceito de documento, passando por seu papel nos arquivos e bibliotecas e transitando pela história da fotografia. Inicialmente o objeto é contextualizado para se passar à apresentação das regras do AACR2 e da ISAD (G), até a catalogação eletrônica que é possível através da utilização do formato MARC 21. Desse modo, são descritos alguns dos elementos que o documento fotográfico traz em sua composição e em seu suporte, pois é através de suas diversas características físicas que se encontram parte das peculiaridades que instigam inúmeras discussões a seu respeito. Diante da referida base teórica, uma análise panorâmica das regras expostas durante o trabalho é feita a partir dos modos de representação de cada uma: para a biblioteconomia, sua ficha que materializa o ato da descrição e disponibiliza o item no acervo e, para a arquivologia, seus instrumentos de pesquisa que, da mesma forma, oferecem aos usuários um quadro não só do material como de todo o contexto de seu acervo. Por fim, chega-se a uma aproximação de pontos nas duas normas que merecem atenção e aprofundamento por parte de pesquisadores e de profissionais que lidam com o documento fotográfico. Sob a luz dos princípios arquivísticos e da teoria do tratamento biblioteconômico, reflete-se sobre a descrição de forma geral e nesta quando aplicada a um documento que carrega particularidades e é alvo de debates que repercutem na sua disponibilização para os usuários e em seu estudo de forma geral.
This work boards the photographic document in the scope of its description in archives and libraries. The objective is to make possible the comparison between the AACR2 rules, utilized for bibliographic description in libraries and the ISAD (G) norm, which are the rules to obtain an archivist description. Departing from document concept, passing by his function in archives and libraries and passing by photography history. This is the object context in a first moment, leading to the presentation of AACR2 rules and ISAD (G), until the electronic cataloguing which is possible by the use of MARC 21 format. This way, some elements of photographic document bring in its composition and support is described, because through his various physical characteristics we found part of the particularities that instigate countless discussions about it. In front of the referred theoric basis, a panoramic analysis of the present rules is made following the representation ways for each one: for the librarianship, its cards materialize the description act and make available the item in the collection and, to archival science, its tools of research which, in the same way, offer to the users a view not only of the material but his context in the collection. At last, is reached an approach of points in the two norms worthily attention and a profound study by researchers and professionals working the photographic document. Under archivist's principles and librarian treatment theory, there is a consideration about description in general form and its application in a document with peculiarities and when the document is target of discussions that reflect in availability to the users an its studies generally.
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Albuquerque, Ana Cristina de. "Catalogação e descrição de documentos fotográficos em bibliotecas e arquivos : uma aproximação comparativa dos códigos AACR2 e ISAD (G) /." Marília : [s.n.], 2006. http://hdl.handle.net/11449/95536.
Full textAbstract:
Orientador: Eduardo Ismael Murguia MarañonBanca: Solange Ferraz de Lima
Banca: Mariângela Spotti Lopes Fujita
Resumo: A presente pesquisa aborda o documento fotográfico no âmbito de sua descrição em arquivos e bibliotecas. Tem o objetivo de fazer uma possível comparação entre as normas AACR2, utilizadas para a descrição bibliográfica nas bibliotecas e a norma ISAD (G) que, por sua vez, é o conjunto de regras para que seja obtida a descrição arquivística. Para tanto, parte-se do conceito de documento, passando por seu papel nos arquivos e bibliotecas e transitando pela história da fotografia. Inicialmente o objeto é contextualizado para se passar à apresentação das regras do AACR2 e da ISAD (G), até a catalogação eletrônica que é possível através da utilização do formato MARC 21. Desse modo, são descritos alguns dos elementos que o documento fotográfico traz em sua composição e em seu suporte, pois é através de suas diversas características físicas que se encontram parte das peculiaridades que instigam inúmeras discussões a seu respeito. Diante da referida base teórica, uma análise panorâmica das regras expostas durante o trabalho é feita a partir dos modos de representação de cada uma: para a biblioteconomia, sua ficha que materializa o ato da descrição e disponibiliza o item no acervo e, para a arquivologia, seus instrumentos de pesquisa que, da mesma forma, oferecem aos usuários um quadro não só do material como de todo o contexto de seu acervo. Por fim, chega-se a uma aproximação de pontos nas duas normas que merecem atenção e aprofundamento por parte de pesquisadores e de profissionais que lidam com o documento fotográfico. Sob a luz dos princípios arquivísticos e da teoria do tratamento biblioteconômico, reflete-se sobre a descrição de forma geral e nesta quando aplicada a um documento que carrega particularidades e é alvo de debates que repercutem na sua disponibilização para os usuários e em seu estudo de forma geral.
Abstract: This work boards the photographic document in the scope of its description in archives and libraries. The objective is to make possible the comparison between the AACR2 rules, utilized for bibliographic description in libraries and the ISAD (G) norm, which are the rules to obtain an archivist description. Departing from document concept, passing by his function in archives and libraries and passing by photography history. This is the object context in a first moment, leading to the presentation of AACR2 rules and ISAD (G), until the electronic cataloguing which is possible by the use of MARC 21 format. This way, some elements of photographic document bring in its composition and support is described, because through his various physical characteristics we found part of the particularities that instigate countless discussions about it. In front of the referred theoric basis, a panoramic analysis of the present rules is made following the representation ways for each one: for the librarianship, its cards materialize the description act and make available the item in the collection and, to archival science, its tools of research which, in the same way, offer to the users a view not only of the material but his context in the collection. At last, is reached an approach of points in the two norms worthily attention and a profound study by researchers and professionals working the photographic document. Under archivist's principles and librarian treatment theory, there is a consideration about description in general form and its application in a document with peculiarities and when the document is target of discussions that reflect in availability to the users an its studies generally.
Mestre
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Baatarkhuu, Zoljargal. "Metabolic labelling of bacterial isoprenoids produced by the methylerythritol phosphate pathway : a starting point towards a new inhibitor." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF029/document.
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Les isoprénoïdes, présents dans tous les organismes vivants, sont synthétisés selon deux processus: la voie du Mevalonate et la voie Méthylérythritol phosphate (MEP). Cette dernière, absente chez l’humain, est très étudiée car elle représente une cible pour le développement de nouveaux antimicrobiens. Le ME-N3, un analogue du méthylérythritol portant un azoture, a été synthétisé et exploité dans des expériences de marquage métabolique de la voie MEP en utilisant un couplage bioorthogonale suivi d’une analyse par LC/MS. De façon intéressante, nous avons découvert que le MEP-N3, un analogue du MEP, inhibe l'enzyme IspD d’ E. coli (3ème enzyme de la voie MEP). Les études cinétiques ont révélé que le MEP-N3 possède la meilleure activité inhibitrice sur IspD d’ E.coli en comparaison avec les inhibiteurs connus, et que le mécanisme d'inhibition est de type mixte. Une étude détaillée du mécanisme de la réaction catalysée par IspD a été réalisée pour la première fois, en utilisant une analyse cinétique à deux substratsIsoprenoids, present in all living organisms, are synthesised according to two routes: the Mevalonate and the Methylerythritol phosphate (MEP) pathways. The MEP pathway, absent in humans, is extensively investigated as it is a target for the development of new antimicrobials. ME-N3 an azide tagged analogue of methylerythritol was synthesised and utilised for metabolic labelling studies of the MEP pathway using bioorthogonal ligation followed by LC-MS analysis. Interestingly, we found that MEP-N3, an analogue of MEP, inhibits E.coli IspD (3rd enzyme of the MEP pathway). Further inhibition kinetic studies revealed that MEP-N3 possesses the highest inhibitory activity on E.coli ispD when compared to known inhibitors. In addition, the mechanism of inhibition of E.coli ispD by MEP-N3 was found to be best described using a mixed type model. Moreover, determination of the IspD reaction mechanism has been carried out for the first time, by virtue of a bisubstrate steady state kinetic analysis
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Hsu, Shih-Chieh. "UNDERSTANDING THE ROLE OF SOCIAL CAPITAL IN EXPERTISE COORDINATION IN INFORMATION SYSTEMS DEVELOPMENT (ISD) TEAMS." Doctoral diss., University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2265.
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Information system development (ISD) project is a knowledge-intensive teamwork process which requires members to coordinate their expertise to generate the final outcome. Breakdown or coordination and insufficient knowledge integration have been reported as critical factors which lead to ISD project failure. Most existing coordination literature focus on the effect of administrative coordination mechanisms toward project performance which hints that more efforts are needed to understand expertise coordination and explore ways to improve it. Addressing the above issues, two studies in this dissertation attempt to understand expertise coordination within the IS development team based on social capital perspective. The first study, based on intention-behavior literature, knowledge management research, and Gerwin's (2004) coordination model, investigates relationships among willingness, competence, and actual expertise coordination. The relationships between expertise coordination and teamwork outcomes are also examined. The second study incorporates social capital theory and examines (1) dependencies among three dimensions of social capital and (2) linkage between social capital and expertise coordination. Data collected from more than five hundred information systems project team members was used to test the proposed hypotheses. The analysis results confirmed most of the hypotheses. This dissertation contributes to coordination, project management, and team mental model research through many perspectives. In each study, directions for management practice and future research are discussed.Ph.D.
Department of Management Information Systems
Business Administration
Business Administration PhD
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Liu, Lixuan. "MMV008138 and analogs: potential novel antimalarial agents for P. falciparum." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/95315.
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Malaria is a severe and deadly mosquito-borne disease. Although treatable, the continuous emergence of multi-drug resistant parasite strains urgently calls for the development of novel antimalarial agents. P. falciparum parasites synthesize essential isoprenoid precursors, isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), via a non-mevalonate pathway: the methylerythritol phosphate (MEP) pathway. This pathway is not utilized by humans. Thus, compounds that target the MEP pathway and disrupt isoprenoid biosynthesis in P. falciparum hold promise as potent and safe new antimalarial agents, that engage new targets.
Previously, we and others identified MMV008138 from the Malaria Box as a MEP pathway targeting compound. Later work revealed that it targets the IspD enzyme within the MEP pathway. Work in the Carlier group has established preliminary structure-activity relationship (SAR) of MMV008138: 1) (1R,3S)-configuration is required; 2) 2', 4'-disubstitution of the D-ring with small, electronegative substituents; 3) functional importance of carboxylate acid at C3.
In this work, I aim to gain further insight into the C3 SAR and A-ring SAR of lead compound MMV008138. Synthesized acid bioisosteres and A-ring analogs of MMV008138 were evaluated in their ability to inhibit P. falciparum parasite growth. We showed that the C3 substituent of MMV008138 has a very tight SAR, and likely interacts with a very constricted pocket within the PfIspD enzyme. A-ring modifications are limited to certain positions of MMV001838 and need to be sterically small. However, we have yet to identify a modification that significantly improves drug lead potency.
Future work will continue towards understanding the A-ring SAR of MMV008138, as well as D-ring SAR and C1-SAR. Efforts will also be directed towards finding analogs with improved potency, transport and metabolic stability.MS
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Abujamel, Turki. "Molecular genetic characterization of ispD, a gene coding for a novel immunogenic surface protein with a role in Listeria monocytogenes virulence." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27661.
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Listeria monocytogenes is a Gram-positive intracellular bacterial pathogen that causes severe invasive infections (listeriosis) in humans. A novel protein of unknown function from L. monocytogenes serotype 4b, designated IspD, was previously identified as an immunogenic target that reacts with antiserum (RalphaL) from rabbits infected with live L. monocytogenes but not with antiserum (RalphaK) from animals immunized with heat-killed bacteria (Yu, MSc. thesis, 2004). This findings suggests that IspD is induced specifically or significantly upregulated in vivo during L. monocytogenes infection and thus may be important in bacterial pathogenesis. The open reading frame (ORF) of ispD, which had been partially determined in the previous study, was further sequenced to obtain a complete ORF of 3,222 by coding for a 116 kDa protein of 1073 amino acids. Bioinformatics analysis of the deduced amino acid sequence of IspD revealed that this protein contained an N-terminal signaling peptide, leucine rich repeats (LRRs), and a C-terminal cell wall anchoring motif LPXTG, characteristic of a surface protein of the internalin family. The recombinant form of putatively mature IspD, expressed in Escherichia coli, was purified and used to raise specific polyclonal antibodies in rabbits for protein characterization. Immunofluorescence and immunogold labeling using anti-IspD antibodies showed that IspD was localized on the bacterial surface, consistent with the presence of a LPXTG motif within IspD. A low level of the native IspD, expressed by L. monocytogenes, was detected in all phases during a 48-h in vitro growth, although the gene was transcribed only in the early to exponential growth phases. This, together with the previous findings, suggests that IspD is upregulated during in vivo infection. Regulated expression of IspD is demonstrated by an increased expression of IspD following recovery from oxidative stress in brain heart infusion and buffered Listeria enrichment broths. Role of IspD in L. monocytogenes virulence was investigated by in-frame deletion of the ispD gene from the bacterial chromosome to create a DeltaispD mutant strain. This mutant exhibited complete abrogation of expression of IspD and showed no defects in in vitro growth, colony and microscopic morphologies, or biochemical properties. The cell culture infection assays using number of mammalian cell lines for adhesion and invasion demonstrated that the Delta ispD mutant is impaired in adhesion to and invasion of Hep-G2 and L132 cells only compared to the wild-type. This result indicates an involvement of IspD in bacterial adhesion and invasion in a cell-type dependent manner. Furthermore, intracellular growth of the DeltaispD mutant in a selected epithelial cell line Vero but not in the murine phagocytic cell line J774 was attenuated at a late infection stage. Altogether, evidence from this study strongly suggests that IspD, an immunogenic surface stress response internalin-like protein, plays a role in L. monocytogenes virulence.
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Karlstedt, Johan M. "An ISD study of Extreme Information Management challenges in IoT Systems - Case : The “OpenSenses”eHealth/Smarthome project." Thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-4821.
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Context: Internet of Things (IoT) is an exciting new development and opportunity in the global ICT field. In short, IoT means that all objects will have their own IP address and be constantly online, connected to other similar actors. After this expansion Internet will not only be humans communicate with humans (H2H) more but machines will automatically communicate with machines (M2M) and humans (H2M) as well . The already today big amounts of data will become extreme as a result of this and it will require new and smarter ways of designing future ICT systems. Many more things needs to be taken into account for these demanding ICT development projects to fall out in productive ways. As of right now it does not seem to be clear to developers what all matters need to be looked at and in that order and why. Clear IoT systems design guidelines, templates and view-models are missing or they are at least not available to the mainstream designers. Objectives: In this study the objective is to investigate a) what views and concepts would need to be taken into account for developers to design better Information Systems for IoT type of setups and b) what kind of an ISD framework such design could result in. Methods: In this thesis a number of research methods have been used, such as: a) conducting a broad literature review on related IS concepts; b) analyzing how the found concepts tie togehter; c) compiling an ISD framework based on the concepts and 2) apply the ISD framework on a real eHealth case. Results: The result of the study was that there is a need for a new ISD framework for larger systems design based on a stakeholder centric viewpoint. This work puts forward an example of such an ISD framework. Conclusions: Designing and developing large Information Systems for IoT setups is a very demanding task and a logical/clear design frameworks will help in this matter. If nothing else, a predefined view-model will help in asking the right (kind) of questions and keeping the communication about the objectives on track and focused. eHealth is a field where IoT systems should be implemented but if it's not done in the correct way taking matters like stakeholders objectives and IPR's on both systems and data into account very little productive results will be achieved.
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Rößler, Nicolas. "Der triftige Grund in der Besitzstandsschutzrechtsprechung des Ruhegeldsenats des Bundesarbeitsgerichts : zur Übertragbarkeit der wirtschaftlichen Lage iSd 16 BetrAVG /." Frankfurt am Main [u. a.] : Lang, 2005. http://www.gbv.de/dms/spk/sbb/recht/toc/502975733.pdf.
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Vitorino, Miqueias dos Santos. "As interações no diário de aprendizagem do Curso de Letras da UFPB Virtual: uma leitura interacionista sociodiscursiva." Universidade Federal da Paraíba, 2012. http://tede.biblioteca.ufpb.br:8080/handle/tede/6361.
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Previous issue date: 2012-04-04Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Apprenticeship journals have conquered spaces at the educational activities. In the college courses, theses journals are considered as activity instruments used by teachers and students for reflection, discussion and negotiation of the teaching-learning process. It is not different at the education through web context. In this background, journals are reinterpreted by the agents of the educational activity with different characteristics. There are many realities in the web-educational activity whose reveal the complexity of the texts produced at that virtual space. This dissertation, whose nature can be considered qualitative-interpretative, has been worried with the following question: how the use of apprenticeship journals by agents of an online educational activity can be characterized? We propose as objectives to answer this question and also verify which discursive spheres and figures of action are mobilized in the textual infrastructure and what this all this info can reveal about the online educational activity.It was possible analyze the infrastructural text elements, as context of textual productions,text themes, facts of action and types of discourse and interpret how educational activity works. Then, we observed how and why the agents write at this space and how and why they keep the interaction online. This study is related to GELIT s researches and has as scope this emergent digital genre, considered as an activity instrument and a space for interaction among teachers, tutors and students. The main theoretical support of this study is the Socio-discursive Interactionism (ISD), represented by Bronckart (2006, 2008, 2009), Machado (1998, 2007, 2009) and others. From the texts, which were co-produced by teachers, tutors and students, we analyzed some characteristics linguistically marked of the educational activity, based on the Ergonomics of Activity, represented by Amigues (2004) and Faïta (2002) studies. Our corpus is constituted by four journals, two of them belong to the course of Semantics of Portuguese Language and the two others belong to the course of Didactics of Portuguese Language. Both courses belong to the program of the Curso de Letras of the UFPB Virtual. The analyzed journals revealed the existence of different profiles of the genre, depending on the types of discourse and on the text themes founded: the chronicle journal, inwhich is present the narrative of personal experiences (in)directly (or not) related to the student apprenticeship on the course; the abstract journal, whose text themes are related to the course subjects and uses a theoretical discourse to consolidate the text; the dialogued journal is already acknowledged in the educational scenario by scholars and it is characterized as a interactive text with diversified text themes. Towards the research s results, our contribution keeps the discussion about journal s use opened, as instrument of the educational activity, to discuss the necessity and importance of holding a student particular space to interact with the teacher through writing.
Os diários de aprendizagem, gêneros integrantes da atividade educacional como artefatos e voltados para a produção de textos que têm como conteúdo temático a própria atividade, têm ganhado cada vez mais importância na atividade educacional. Nos cursos de graduação, o diário é considerado como instrumento da atividade, sendo utilizado por professores e alunos para refletir sobre, discutir e negociar o processo de ensino-aprendizagem das disciplinas. Na Educação a Distância (EaD) não é diferente. Nesse contexto, os diários são reinterpretados pelos agentes da atividade educacional, gerando outros valores ao contexto sociointeracional do gênero. São muitas as realidades de atividade educacional a distância, o que revela a complexidade das produções textuais via web. Esta pesquisa, de caráter qualitativo-interpretativista, se fixou ao seguinte questionamento: como se caracteriza o uso de diários de aprendizagem por agentes de uma atividade educacional (professor/tutor e aluno) na modalidade de Educação a Distância? Como objetivos, propomos responder esta questão e ainda verificar, na infraestrutura textual do corpus, quais mundos discursivos e figuras do agir são mobilizados e o que esses dados revelam sobre a atividade educacional a distância nos contextos das produções. Este estudo, portanto, está voltado para esse gênero digital emergente, que tem se mostrado, além de um instrumento da atividade, um espaço para interação particular entre aluno, professor e/ou tutor de uma disciplina. Para realizar essa análise, adotamos como aporte teórico-metodológico o Interacionismo Sociodiscursivo (ISD), representado principalmente pelos trabalhos de Bronckart (2006, 2008, 2009), Machado (1998, 2007, 2009) entre outros, que vão além de uma análise linguística, observando o contexto de produção e elementos sociodiscursivos dos textos. Partindo dos textos co-produzidos por professores, tutores e alunos, também realizamos uma leitura da atividade educacional a partir da perspectiva da Ergonomia da Atividade, que tem em Amigues (2004) e Faïta (2002) como representantes; essa leitura permite que o pesquisador faça um levantamento de algumas características da atividade, que ficam marcadas no discurso dos agentes-produtores do diário. Esta pesquisa, vinculada aos trabalhos desenvolvidos pelo GELIT (grupo de Estudos em Letramentos, Interação e Trabalho), observou alguns fatores que levaram os agentes a escrever e manter a interação no diário. Nosso corpus é constituído por 4 diários, dois deles pertencentes à disciplina Semântica da Língua Portuguesa e os outros dois pertencentes à disciplina Didática da Língua Portuguesa, ambas as disciplinas do Curso de Letras da UFPB Virtual. Os diários analisados nos revelaram a existência de perfis diferentes de gênero, que dependem principalmente dos tipos de discurso e conteúdos temáticos veiculados: o diário de relato, onde se preza o narrar de experiências pessoais (in)diretamente relacionados (ou não) ao aprendizado na disciplina; o diário-resumo, que tem como conteúdos temáticos principalmente os conteúdos da disciplina, centrada em um discurso teórico, fundido ou não com o discurso interativo; o diário dialogado, que já não é uma novidade no cenário educacional, onde os textos escritos pelos agentes caracterizam uma espécie de interação por escrito e o conteúdo temático é variado. Diante dos resultados, a nossa contribuição mantém aberta a discussão sobre o uso do diário, enquanto instrumento da atividade, para discutir a necessidade e importância da existência de um espaço particular do aluno para interagir, via escrita, com o professor/tutor.
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Björkelid, Christofer. "Enzymes in the Mycobacterium tuberculosis MEP and CoA Pathways Targeted for Structure-Based Drug Design." Doctoral thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-179057.
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Tuberculosis, caused by the pathogenic bacteria Mycobacterium tuberculosis, is one of the most widespread and deadly infectious diseases today. Treatment of tuberculosis relies on antibiotics that were developed more than 50 years ago. These are now becoming ineffective due to the emergence of antibiotic resistant strains of the bacteria. The aim of the research in this thesis was to develop new antibiotics for tuberculosis treatment. To this end, we targeted enzymes from two essential biosynthetic pathways in M. tuberculosis for drug development. The methylerythritol phosphate (MEP) pathway synthesizes a group of compounds called isoprenoids. These compounds have essential roles in all living organisms. The fact that humans utilize a different pathway for isoprenoid synthesis makes the MEP pathway enzymes attractive targets for drug development. We have determined the structures of two essential enzymes from this pathway by X-ray crystallography: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) and 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD). These are the first structures of these enzymes from M. tuberculosis. Additionally, structures of the IspD enzyme from the related bacteria Mycobacterium smegmatis were determined. We have characterized these enzymes and evaluated the efficiency of a number of inhibitors of the DXR enzyme by biochemical methods. Crystal structures of DXR in complex with some of these inhibitors were also determined. The second pathway of interest for drug development is the universal pathway for Coenzyme A biosynthesis. Enzymes in this pathway have essential roles in all living organisms. However, the bacterial enzymes have little similarity to the human homologues. We have determined a number of structures of the M. tuberculosis pantothenate kinase (PanK), the regulatory enzyme of this pathway, in complex with two new classes of inhibitory compounds, and evaluated these by biochemical methods. The structures and biochemical characterization of these enzymes provide us with detailed information about their functions and broadens our knowledge of these bacteria. Biochemical and structural information about new inhibitors of these enzymes serve as a starting point for future development of antibiotics against tuberculosis.
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Galvão, Rosa Maria Brandão Tavares Marcelino. "Estruturas conceptuais e técnicas de gestão bibliográfica." Doctoral thesis, Universidade de Évora, 2014. http://hdl.handle.net/10174/18181.
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A evolução da infraestrutura tecnológica, aliada à disponibilização dos recursos e serviços bibliográficos na Internet/WWW, fizeram emergir a discussão sobre modelos e paradigmas da função, meios e objetivos dos serviços de informação de biblioteca. O universo normativo da informação torna-se heterogéneo e ultrapassa as fronteiras de influência das bibliotecas, impulsionando um movimento internacional de refundação dos princípios, normas e regras do seu âmbito.
Esta tese investiga as novas questões técnicas que se colocam no âmbito da organização e acesso à informação, emergentes do enquadramento teórico trazido pelos Requisitos funcionais dos registos bibliográficos (FRBR). No cerne da investigação estão as estruturas normativas e a sua interação com os sistemas, conteúdos, utilizadores e rede, tendo esta tese limitado o seu âmbito ao estudo dos normativos de estrutura, focando-se nos conceitos, princípios e normas de informação e de dados que estão subjacentes aos sistemas de informação bibliográfica. A primeira questão investigada foi a identificação das características intrínsecas a um catálogo FeRBeRizado, para cuja resposta foi estudado o modelo FRBR, verificadas as suas características fundamentais e a aplicabilidade atual, com a análise de um conjunto de catálogos FeRBeRizados. Verificou-se haver necessidade do redesenhar das estruturas lógicas da informação dos catálogos, conducentes a uma remodelação da organização e colocação dos seus conteúdos que permitam uma melhor definição/consolidação dos objetivos do catálogo, e a restituição de uma estrutura sindética mais rica. O modelo FRBR ao desagregar, decompor e remodelar os dados bibliográficos fornece a formalização lógica para a reestruturação da informação bibliográfica.
Estes resultados conduziram à segunda e terceira questões sobre se os normativos catalográficos atualmente disponíveis – ISBD e RDA, e os normativos de registo de dados – UNIMARC, são suficientes e adequados para implementar essa estrutura. Analisadas as características fundamentais destes normativos ao nível de potencialidades e limitações de modelação dos dados de acordo com o modelo FRBR, verificou-se que a Descrição bibliográfica Internacional Normalizada (ISBD) apresenta uma tendência de alinhamento conceptual mas não se reestruturou de acordo com o modelo FRBR; já o Resource Description and Access (RDA), transpõe os conceitos teóricos do modelo para a prática catalográfica e apresenta um corte radical com a filosofia, conceitos, terminologia e práticas usadas tradicionalmente na catalogação e na gestão de dados bibliográficos. A estrutura atual do UNIMARC possui os requisitos essenciais para acomodar uma catalogação que implemente o modelo FRBR. No entanto, tal como os outros formatos MARC, é uma norma demasiado extensa, complexa e sem um modelo de dados claro, tendo evoluído de forma incremental, sem possuir as características adequadas aos atuais requisitos de gestão e exploração de dados.
Conclui-se pela necessidade inequívoca de os normativos MARC virem a ser, no médio ou longo prazo, substituídos por normas de estrutura de dados melhor alinhadas com o contexto conceptual e tecnológico atual, de que a web semântica é parte fundamental; CONCEPTUAL STRUCTURES AND BIBLIOGRAPHIC MANAGEMENT TECHNIQUES:
New issues and perspectives
Rosa Maria Brandão Tavares Marcelino Galvão
ABSTRACT:
The evolution of technological infrastructures, in association with the availability of resources and bibliographic services on the Internet/World Wide Web, has given rise to the discussion of models and paradigms of function, as well as means and goals of library information services. The normative universe of information is heterogeneous and transcends the boundaries of libraries, calling for an international movement to recast the principles, standards and rules of its field.
This thesis investigates the new technical issues that arise from the means of accessing and organizing information, in accordance with the theoretical framework introduced by the Functional Requirements of Bibliographic Records (FRBR). The normative structures and their interaction with systems, contents, users and networks are at the core of this study. This research limited its scope to the study of normative structures, focusing on the concepts, principles and standards of information and data that underlie the bibliographic information systems.
After verifying and validating the fundamental characteristics and applicability of the FRBR model, we analyzed a set of FRBR-based catalogs. We found it to be necessary to redesign the logical structure of catalog information. Remodelling of the organization and placement of contents would therefore be of critical importance in better elucidating and consolidating catalog objectives, and restoring a richer syndetic structure. By disrupting and reshaping bibliographic data, the FRBR model seems to provide a logical and suitable standard for restructuring bibliographic information.
These results led to the subsequent question of whether the cataloging standards currently available – International Standard Bibliographic Description (ISBD), Resource Description and Access (RDA), and data record format UNIMARC –, are sufficient and appropriate to implement this new structure. After careful analysis of the strengths and constraints of these protocols for FRBR data modeling we observed that ISBD has a tendency for conceptual alignment, though it does not restructure data according to the FRBR model. On the other hand, RDA transposes the theoretical concepts from the model to the cataloguing practice. It presents a radical break from the philosophy, concepts, terminology and practices traditionally used in cataloguing and managing bibliographic data. The current structure of UNIMARC features all the core requirements for a cataloguing method that implements the FRBR model. However, like other MARC formats, it is too extensive, complex, and lacks clear evidence-based data. It has evolved incrementally without meeting all the necessary requirements for current data management.
We concluded that, given the current challenges, there is a need for MARC protocols to be replaced by new normative data structures. Potential new protocols must be in agreement with the current conceptual and technological contexts, of which the semantic Web is part.
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Barros, Webert Cavalcanti. "Práticas de letramento no processo de ensino-aprendizagem em português língua estrangeira." Universidade Federal da Paraíba, 2011. http://tede.biblioteca.ufpb.br:8080/handle/tede/6355.
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Previous issue date: 2011-03-30Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Throughout two years (2008-2009), at the Federal University of Paraíba (UFPB), I tried to lead students from other countries to learn Portuguese as a Foreign Language (PFL) in a situated and contextualized way. From this perspective, the reflection upon the social uses of textual genres has become crucial, since, as is well known, we use genres in order to act in society. The theoretical contributions of Bronckart (1985, 1996, 1999, 2006, 2008) served as a foundation in this action research, in order to bring the students to act communicatively, that is, through language. Therefore, my research questions are the following: do the literacy practices in PFL influence the way in which students position themselves when developing certain textual genres? What are the consequences or impacts of these practices in the way they position themselves in written texts? Do marks of enunciation, more precisely, the modalizations used by students, favor the achievement of the objectives in mind? My hypothesis revolved around the belief that during the development of written textual production, students use enunciative mechanisms, which, on guiding the reader´s interpretation, constitute key elements for achieving the goals which motivated the students to construct such texts. Dwelling on the analysis of two textual genres, namely, educational memories and letters (personal and addressed to public bodies), a comparison is made between texts written by students of different levels (basic/advanced), so as to find out whether the texts written by elementary level students highlight the development of these practices in a significant way, as well as between students from the same level (basic/basic, advanced/advanced), so as to comprehend if the relevance of these practices relate to an isolated case, or whether, in fact, they were reaching the majority of the students from the same level. The analyzed genres reveal that students generally knew how to deal with words, with good levels of persuasion, in view of the objectives, as well as with the interlocutor in mind. Although students, especially those from more advanced levels, already have well-developed literacy practices in their first language, the mere fact of having participated in a learning process that encompassed literacy practices enabled them to further develop certain skills in another language, in a new culture.
Ao longo de dois anos (2008-2009), na Universidade Federal da Paraíba (UFPB), procuramos levar estudantes provenientes de outros países a aprenderem o Português Língua Estrangeira (PLE) de maneira situada, contextualizada. Nessa perspectiva, a reflexão acerca dos usos sociais dos gêneros de texto tornou-se fundamental, uma vez que, conforme já é bem sabido, utilizamos os gêneros para agir em sociedade. Os aportes teóricos de Bronckart (1985, 1996, 1999, 2006, 2008) serviram-nos de base para o encaminhamento de nossa pesquisa-ação, tendo em vista levar o estudante a agir comunicativamente, ou seja, por meio da linguagem. Assim, tivemos como um de nossos objetivos o interesse de responder à seguinte questão: as práticas de letramento em PLE influenciam no modo como os estudantes se posicionam ao elaborarem determinados gêneros de textos ou quais os desdobramentos ou impactos dessas práticas no modo como se posicionam nos textos escritos? As marcas enunciativas, mais precisamente, as modalizações utilizadas pelos estudantes favorecem o alcance dos objetivos em mente? Nossa hipótese girou em torno do fato de crermos que, durante o desenvolvimento de produções textuais, neste caso, escritas, os estudantes utilizam mecanismos enunciativos, que, por orientarem a interpretação do leitor, acabam se configurando como elementos fundamentais para se atingir os objetivos que os motivaram a construir tais textos. Detendo-nos na análise de dois principais gêneros de texto, a saber, relatos ou memórias educativas e cartas (pessoais e endereçadas a instâncias públicas), ora comparamos textos elaborados por estudantes de níveis distintos (básico/avançado), para sabermos até que ponto os textos de estudantes do básico evidenciavam os desdobramentos de nossas práticas de maneira significativa, ora por estudantes de mesmo nível (básico/básico, avançado/avançado), para sabermos até que ponto a relevância dessas práticas estava relacionada a um caso isolado ou se, de fato, estavam atingindo a maioria dos estudantes de um mesmo nível. Os gêneros analisados revelam que os estudantes de modo geral souberam lidar com as palavras, apresentando, inclusive, bons níveis de persuasão, tendo em vista os objetivos propostos, assim como o interlocutor que se tinha em mente. Embora os estudantes, principalmente de níveis mais avançados, já terem bem desenvolvidas as práticas de letramento em sua língua materna, o simples fato de terem participado de um processo de aprendizagem que contemplasse práticas de letramento, possibilitou-lhes desenvolver ainda mais certas habilidades, em outra língua, em uma nova cultura.
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Castillo, Alfred. "Respondent Perceived Threat During the Information Systems Requirements Determination Process: Understanding and Mitigation." FIU Digital Commons, 2017. https://digitalcommons.fiu.edu/etd/3549.
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Requirements determination is a critical driver in a successful software development process. Despite decades of research prescribing various software development methodologies, intended to aid in achieving an eventual convergence between the user’s mental models and an informationally equivalent representation that is codified within an information system, we can still attribute many of the deficiencies in software development projects to the improper or ineffective execution of the requirements determination process. This study draws on the user resistance, software development, and psychology literature to discuss how perceived threats by potential users and key respondents can result in sub-optimization of a proposed information system via reduction in the quality of their responses during the requirements gathering phase. A laboratory experiment was carried out to explore the sources and effects of various threat perceptions and the effectiveness of techniques intended to detect and mitigate such perceptions of threat. The results confirm that perception of threat does lead to a degradation in response quality, with perceived adaptability fully mediating the relationship. The findings on whether interviewer reassurance has a moderating effect on the relationship between threat and perceived adaptability had interesting results, which are discussed.
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Silva, Fabio Pessoa da. "O agir docente em contexto de EJA: saberes, gestos e práticas do professor-alfabetizador." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/8446.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Teaching act, understood as a work, is something that requires an understanding of the multidimensionality constitutive of teaching activity, considered by a sociointeractionist view, which allows to evaluate the individual actions as a reflection of their conceptions/representations built and/or acquired in the social environment. This research focuses on the epistemological approach of the Sociodiscursive Interactionism (SDI) and its main theoretical and methodological contributions, with the assumptions of Bronckart (1999; 2006; 2008); the Work Sciences (the Ergonomy and the Clinic of Activity) , the studies of Clot (2007; 2010); Nouroudine (2002) and Amigues (2004); and Education theories specifically regarding the Didactics, with studies of Tardif (2014); Chevallard (1991; 2013); Aeby-Daghé & Dolz (2008) and Schneuwly (2000). The investigation of this research is focused on the act of the literacy-teacher who works in the Brazil Literacy Programme (Programa Brasil Alfabetizado - PBA). The goal is to understand the teaching practice of literacy-teacher in the context of Youth and Adult Education (Educação de Jovens e Adultos – EJA), considering the relationship between the didactic gestures and teaching knowledge presented in their conceptions and their performances. This aim, based on this relation, is to investigate to what extension an analysis of literacy-teachers’ act in teaching young and old students can reveal their knowledge, specific gestures and practices. In this research, there are two collaborators who work in the PBA at urban schools, in the municipality of Jacaraú-PB. The adopted methodological approach consists of three stages of analysis, including the represented/interpreted work and the performed work. Thus, the collection and provision of data necessarily were carried out through, firstly semi structured interviews to check the teachers’ conceptions and their implied knowledge; secondly, filming three classes of each collaborator to check and categorize didactic gestures mobilized by them. Thirdly, a simple self-confrontation session with both literacy-teachers in order to get their interpretations of the implemented pedagogical act. With all the data, each stage was analyzed separately, using as categories, the thematic content and the linguistic-discursive materialization proposed by the SDI, in Machado and Bronckart (2009), in addition to the founding didactic gestures defined by Aeby-Daghé & Dolz (2008). In the end, there was a triangulation of data, bringing together all realization, in order to get a more accurate view of the investigated object. As conclusions, it was found that there are eight evidenced conceptions in the literary-teachers of the PBA, which are in the base of their specific didactic gestures’ performance. In addition, the interpretations of their own act reveal that the higher is the teaching experience, the higher is the tendency of the educator to shield him/herself and avoid explicitly self-reflections that expose his/her weaknesses and unexpected actions in their pedagogical activity. Therefore, as a result of all the analysis after triangulation, it was found that experiential knowledge derived from practice in the classroom is what permeates and guides the generation, doing and interpretation of these literacy-teachers of young people and adults. This fact confirms the thesis that pedagogical practice of the literacy-teachers of young and adult students in the Literate Brazil Program is permeated by didactic gestures and acquired and (re)focused knowledge, mainly in / by the experience in the classroom.
O agir docente, entendido como trabalho, é algo que requer uma compreensão da multidimensionalidade constitutiva da atividade de ensino, vista por uma ótica sociointeracionista, a qual permite avaliar as ações dos indivíduos como sendo reflexo de suas concepções/representações construídas e/ou adquiridas no social. A presente pesquisa centra-se nessa abordagem epistemológica e tem como principais aportes teórico-metodológicos o Interacionismo Sociodiscursivo – ISD, com os pressupostos de Bronckart (1999; 2006; 2008); as Ciências do Trabalho (Ergonomia e Clínica da Atividade), com os estudos de Clot (2007; 2010); de Nouroudine (2002) e de Amigues (2004); e as Teorias da Educação, especificamente, relativas à Didática, com os estudos de Tardif (2014); Chevallard (1991; 2013); Aeby-Daghé & Dolz (2008) e Schneuwly (2000). O objeto de investigação é o agir do professor-alfabetizador de Jovens e Adultos atuante no Programa Brasil Alfabetizado (PBA). O objetivo central é compreender a prática pedagógica dos professores-alfabetizadores em contexto de EJA, considerando a relação entre os gestos didáticos e os saberes docentes presentes em suas concepções e realizações do agir. Tal objetivo resulta da problemática que é investigar em que medida uma análise do agir docente do alfabetizador de jovens e adultos pode revelar saberes, gestos e práticas específicas desse professor. Participam da pesquisa dois professores colaboradores que atuam no PBA, no município de Jacaraú-PB, em escolas da zona urbana. O percurso metodológico adotado é composto de três momentos de análise, incluindo o trabalho representado/interpretado e o trabalho realizado. Assim, a constituição dos dados correspondeu necessariamente a tal percurso, a saber, primeiro, a realização de entrevistas semiestruturadas para verificar as concepções docentes e os saberes nelas implicados; segundo, a filmagem de três aulas de cada colaborador para verificar e categorizar os gestos didáticos por eles mobilizados; e terceiro, uma sessão de autoconfrontação simples com ambos os alfabetizadores a fim de obter as suas interpretações acerca do agir pedagógico implementado. De posse do conjunto dos dados, fez-se a análise de cada etapa, separadamente, utilizando como categorias o nível do conteúdo temático e o da materialização linguístico-discursiva propostos no quadro do ISD, conforme Machado e Bronckart (2009), além dos gestos didáticos fundadores definidos por Aeby-Daghé & Dolz (2008). Ao final, fez-se uma triangulação dos dados, reunindo todas as constatações, com o propósito de obter uma visão mais apurada do objeto investigado. Como conclusões, verificou-se a existência de oito concepções docentes evidenciadas no dizer dos alfabetizadores do PBA, as quais estão na base da realização dos seus gestos didáticos específicos. Além disso, as interpretações do próprio agir feitas pelos respectivos professores revelam que, quanto maior a experiência docente, mais o educador tende a evitar explicitamente autorreflexões que desvelem as fragilidades e os imprevistos do seu agir professoral. Portanto, como desdobramentos de todas as análises, após a triangulação, ficou constatado que os saberes experienciais oriundos da prática em sala de aula são o que perpassa e orienta tanto o conceber, quanto o fazer e o interpretar desses alfabetizadores de pessoas jovens e adultas. Esse fato serviu para confirmar a tese de que a prática pedagógica do alfabetizador de jovens e adultos atuante no Programa Brasil Alfabetizado é permeada por gestos didáticos e saberes docentes adquiridos e (re)orientados, sobretudo, na/pela vivência em sala de aula.
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Andersson, Viktor, Emil Berg, Emanuel Bergsten, Johan Classon, Tony Fredriksson, Max Halldén, and Niklas Ljungberg. "Övervakningsfunktion för en mätplattform för mätning i bil – erfarenhetsrapport från kandidatprojekt i programvaruutveckling." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-107503.
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Denna rapport innehåller de samlade erfarenheterna från ett produktutvecklingsprojekt i kursen TDDD77 vid Linköpings universitet. Projektets mål var att skapa en applikation för att visualisera mätdata från en specialutrustad bil på en surfplatta. Detta var önskvärt då det inte fanns något sätt att se om någon sensor slutade fungera mitt i ett test. Projektet delades upp i en förstudie följd av tre iterationer, där en färdig produkt presenterades på en teknisk mässa i slutet av iteration 3. Resultaten visar att Essence Kernel Alpha States kunde användas som en hälsokontroll för projektet, men då de kunde ses som rätt vaga och lämnade rum för tolkning passade det bäst som ett komplement till exempelvis milstolpar. Att använda Google Protocol Buffers sågs som ett viktigt tekniskt val tillsammans med uppdelningen av klienten i front- och back-end. Protobuf underlättade kommunikationen mellan server och klient som annars krävt ett nyskapat protokoll. Uppdelningen av front- och back-end underlättade inte bara resursfördelningen vid utveckling utan även vid felsökning då det i många fall blev lättare att se precis var felet uppkom. Back-ends uppbyggnad gjorde även att den går att återanvända vid eventuell utveckling till flertalet plattformar. Den arbetsprocess som följdes ses som en hybrid mellan agila metoder och vattenfallsmodellen. Mycket erfarenhet finns att hämta från projektet, bland annat hur krav kan ändras och hur en prototyp kan styra mjukvaruutvecklingen åt rätt håll. På grund av att surfplattan distraherar användaren under körning av bil har designen utgått från att minimera interaktionen som krävs med surfplattan under mätning.
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Wilson, Shannae Louise. "Effects on sleep-state organisation of a behavioural intervention for infant sleep disturbance." Thesis, University of Canterbury. Psychology, 2013. http://hdl.handle.net/10092/8044.
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Establishing healthy sleep-wake patterns early in infancy is vitally important as sleep problems can persist. Behavioural sleep interventions such as the parental presence procedure are well established and have been found to improve infant sleep as determined by parent report. The exact nature of this improvement is, however, unclear. Sleep consolidation, sleep-state organisation, and self-soothing are thought likely to change after intervention; however, no known research has comprehensively determined which of these variables change as infant sleep changes in response to intervention. Three participants aged between 7 to 11 months who met the criteria for Infant Sleep Disturbance (ISD) were referred by a Health Centre and the parental presence behavioural sleep intervention was implemented. Parental report and videosomonography (VSG) data were used to measure sleep before and after intervention. While parental report is limited in that parents can only report what they can hear and/or see, VSG offers a tool that can be used to measure sleep-state organisation, state changes, and periods when the infant is awake and quiet. The present research found that infants’ sleep became more consolidated resulting in fewer sleep-wake transitions and night wakings. Infants who had difficulties initiating sleep on their own also demonstrated decrease in Sleep Onset Delay (SOD). Furthermore, infants were found to sleep through a greater number of sleep-state transitions and sleep for a greater duration of time before waking. Collectively this research provides some evidence that changing parental behaviours to those that promote self-initiation through self-soothing and consistency, can change sleep-state organisation and improve self-soothing.
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Green, Rickard. "Development of a 2D Optimal Path Simulation for Ship-to-Shore Cranes : Safe Trajectories within Interchangeable Obstalce Environments." Thesis, Linköpings universitet, Fordonssystem, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-165612.
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The most advanced ports as of writing of this report are at least somewhat autonomous. Whether discussing the transporters between crane and stack (temporary storage) or cranes, the ports are shifting into a completely autonomous system. This ultimate goal presents a challenge in regards to unloading and loading cargo ships in the harbour. How do you achieve unloading of a ship without human intervention while still guaranteeing secure trajectories for the containers? ABB Ports in collaboration with the Division of Vehicular Systems at Linköping University have developed a simulation that utilises a simple control model to investigate the behaviour, limitations and capabilities of such an autonomous crane. Specifically, this simulation utilises a model of the dynamics of a Ship-to-Shore crane (STS), which has the task of unloading a ship. In order to set the crane model in context of realistic scenarios, some additions to the simulation are needed. One of these additions is obstacles. Before this thesis work, the model enjoyed an empty simulation environment to freely optimise how quickly the containers could be transported off of the ship. The addition of obstacles in the form of other containers on the cargo ship as well as the physical presence of the crane’s legs presents new challenges for the optimiser used to solve the optimal control problems formulated through the model in the simulation. The implementation of obstacles is one of the objectives for this thesis. This addition was implemented by modeling the obstacle dimensions and ship limitations by looking at the largest container ships in the world. Due to the simulation not containing obstacles previous to this thesis work, the initial guess provided to the solver initialised the solving in an area of convergence that is unfair to the solver, This rendered the simulation useless, as any obstacle presented to the solver would generate an infeasible solution. Another functionality needed for the obstacle implementation to be meaningful is a solution for guaranteeing safe trajectories for the containers from ship to shore. The solution utilised to reach this goal was to combine a convex hull and safety conditions where the convex hull covers the obstacles, including some padding to prevent collisions between the container carried (load) and obstacles. The safety conditions however calculates the potential positions of the load when an emergency stop occurs, and therefore can prevent the load from swinging into obstacles if there is an emergency stop. These implementations however changes the usefulness and performance of the simulation because of how they shrink the area of convergence for the solver and making some problems non-solvable. When considering both a convex hull and safety conditions, the usability of the simulations is harmed, but can still be utilised to learn about autonomous performance of the simulation. The optimal solutions include some interesting characteristics that can learn crane operators about how the control systems can be utilised. Such a simulation would benefit from continuous development in order to investigate further technologies and features that could improve both performance and usability. Areas such as homotopy, modelling ropes, comparison between simple and nuanced model would be truly interesting for future areas of investigation.
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Yeager, Walter Lee Jr. "The effect of the Capturing Kids' Hearts staff development program in fostering positive teacher-student relationships at Jane Long Middle School in Bryan ISD." Texas A&M University, 2004. http://hdl.handle.net/1969.1/403.
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The purpose of this study was to examine the impact of the Capturing Kids' Hearts staff development program on teacher-student relationships, student engagement, attentiveness, achievement, collaboration, and discipline. The study also sought to measure teacher perceptions of the effectiveness of the training and how teachers implemented methods and strategies from the Capturing Kids' Hearts program.
An extensive review of the literature in regard to teacher-student relationships, student engagement, and student discipline indicated that the emotional connection established between the classroom teacher and the student is the basis of much of a students' success in school. The creation of a positive teacher-student relationship is important in helping students to feel that their academic success and self-importance is valued and deemed worthy by the school organization.
The study involved teachers and students answering a pre-survey and post-survey questionnaire about classroom activities and teacher traits. Teachers and students took the pre-survey before teachers attended the Capturing Kids' Hearts training. At the end of the year all participants answered the post-survey questions. The Capturing Kids' Hearts staff development program is a 3-day retreat where-in teachers learn the techniques and rationale for creating social contracts for organizing their classrooms. Questioning techniques are taught that enable teachers to redirect students with off-task behaviors. Participants are taught different methods of building rapport and trust with students.
Research findings of this study included:
1. Teacher perceptions of the Capturing Kids' Hearts program were more positive than students.
2. Eighth grade students had more positive perceptions of teachers and classrooms than did seventh and sixth grade students.
3. Teachers valued the training and recognized the worth of its implementation in their classrooms.
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Morais, Joácio júnior de Araujo. "Influence des pré-traitements mécaniques et biologiques des Ordures Ménagères Résiduelles (OMR) sur leur comportement bio-physico-chimique en Installation de Stockage de Déchets (ISD)." Lyon, INSA, 2006. http://theses.insa-lyon.fr/publication/2006ISAL0121/these.pdf.
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La directive européenne 99/31/CE sur le stockage des déchets solides fixe des règles de gestion intégrée des déchets. Les pré-traitements mécaniques et biologiques (PTMB) des ordures ménagères doivent permettre de réduire les quantités de déchets stockés et de réduire la fraction biodégradable contenue dans les déchets. L’objectif fixé pour cette thèse a été d’évaluer l’influence des PTMB des ordures ménagères résiduelles sur leur comportement en installations de stockage des déchets. Pour atteindre cet objectif, le travail a été basé d’une part sur l’étude de l’efficacité des opérations de deux procédés industriel et semi-industriel de PTMB (au SDEE-Lozère et au CREED), d’autre part sur l’évaluation au laboratoire du comportement des déchets pré-traités en bioréacteurs de simulation de stockage avec ou sans recirculation de lixiviats. L’influence positive des PTMB des deux procédés est observée ainsi que l’effet de la recirculation sur tous les bioréacteursThe European directive 99/31/CE on the storage of solid waste fixes the requirements of integrated waste management. By mechanical-biological pretreatment (MBP) of residual municipal solid waste it is possible to reduce the quantity of waste to be landfilled and the waste biodegradable fraction. The objective of this PhD thesis was to evaluate the influence of the MBP of residual municipal solid waste on their behaviour in landfill. In this purpose, the work was based on the one hand on the study of the effectiveness of the operations of two industrial and semi-industrial processes of MBP (at SDEE-Lozère and at CREED) and, on the other hand, on the evaluation of the behavior of pretreated waste in laboratory scale test landfill simulation reactor with and without leachate recirculation. The positive influence of the MBP of the two processes is observed as well as the effect of the recirculation on all bioreactors
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Morais, Joácio de Araujo júnior Gourdon Rémy Bayard Rémy. "Influence des pré-traitements mécaniques et biologiques des Ordures Ménagères Résiduelles (OMR) sur leur comportement bio-physico-chimique en Installation de Stockage de Déchets (ISD)." Villeurbanne : Doc'INSA, 2007. http://docinsa.insa-lyon.fr/these/pont.php?id=de_araujo_morais.
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Kunfermann, Andrea Christiana [Verfasser], Michael [Akademischer Betreuer] Groll, and Thomas [Akademischer Betreuer] Kiefhaber. "Structural and functional characterization of the non-mevalonate pathway enzymes IspC and IspD in complex with natural and synthetic ligands / Andrea Christiana Kunfermann. Gutachter: Michael Groll ; Thomas Kiefhaber. Betreuer: Michael Groll." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/104867732X/34.
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Hu, Li. "CORPORATE TRAINING PROFESSIONALS' PERCEPTIONS REGARDING THE USE OF INSTRUCTIONAL SYSTEMS DESIGN IN CHINA: A MIXED METHODS STUDY." OpenSIUC, 2011. https://opensiuc.lib.siu.edu/dissertations/443.
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Meqbel, Manal. "KVALITETSSÄKRING AV BENDENSITOMETRI." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-42833.
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Santos, Joel Fernando da Silva. "Sistema de gestão de arquivo para o Memória de África e do Oriente." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/18010.
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Mestrado em Engenharia de Computadores e TelemáticaO projeto Memória de África nasceu nos finais de 1996 e tem sido executado com a mesma equipa central desde então. Consiste num site em português de acesso livre, http://memoria-africa.ua.pt/ que contém uma base de referências de obras sobre os PALOP e dos locais onde elas se encontram em formato digital, possibilitando a consulta página a página. Pretende-se com esta dissertação criar uma nova secção no Projeto onde seja possível catalogar, pesquisar e explorar documentos de arquivo, com particular destaque para o arquivo fotográfico. Para além da manutenção da atividade de arquivo pretende-se também a criação de um módulo que permita aos utilizadores a identificação de pessoas e locais nas fotografias. Este módulo deverá para além dos comentários dos utilizadores permitir que outros utilizadores validem (ou não) os dados colocados sobre a fotografia e que isso permita a criação de um mecanismo de reputação de utilizadores.
The Memory of Africa project was born in late 1996 and has been running with the same core team ever since. Is a website in Portuguese with free access, http://memoria-africa.ua.pt/ containing a references to works based on the PALOP and the places where they are in digital format, allowing the query page by page. The aim of this thesis create a new section in the Project where it is possible to catalog, search and explore archival documents, with particular emphasis on the photographic archive. In addition to the maintenance of file activity also aims to create a module that allows users to identify people and places in the photographs. This module will in addition to the feedback from users allow others to validate (or not) the data placed on the photo and it allows the creation of a mechanism of reputation for users.
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Sadauskas, Tomas. "Informacinės sistemos klasių modelio kūrimas veiklos žinių pagrindu." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20090304_104619-46917.
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Nepakankamos informacinių sistemų projektavimo priemonių galimybės labai išplečia projekta-vimo proceso trukmę. Dažnai projektavimo ciklas susideda iš kelių etapų. Paprastai pradžioje aprašoma probleminė sritis (kaupiamos žinios apie veiklą), specifikuojami vartotojo reikalavimai, po to sudarinėjami projektiniai sprendimai (sistemos klasių modelis ir kt.). Projektinių sprendimų kūrimas veiklos žinių pagrindu nėra automatizuotas, dėl to šis procesas užtrunka ilgai. Neautomatizuotas IS projektavimas ne tik užtrunka ilgiau, bet ir įveda didesnę klaidos pasitai-kymo galimybę. T.y. žmogiškas faktorius gali lemti, kad bus atsižvelgta ne į visus veiklos žinių bazėje saugomus įrašus. Įrašai taip pat gali būti ne tinkamai interpretuojami ir t.t. Darbe plačiai analizuojamos IS kūrimo priemonės ir atsižvelgiant į privalumus ir trūkumus pasiūlomas metodas proceso optimizavimui. Metodas - skirtas klasių modelio sudarymui pagal veiklos žinias.Insufficient capabilities of information systems design tools extends the duration of the design process. Often, the design cycle consists of several stages. Usually at the beginning, then the domain is described (collected knowledge of the activities), analytics specifies user requirements. Only after this design solution (the system class models, etc.) can be developed. Enterprise Knowledge-based Devel-opment of the design solutions is not automated therefore the duration of the design process is long. There are a lot of disadvantages of not automated process. Non-automated design not only takes longer, but also creates a greater possibility of the error occurrence. That is because the human factor can be taken into account because, that not all the activities stored in the knowledge base. Also records may not be correctly interpreted, and etc. Thus, the expected solution is a method which will be used to generate information system de-sign solutions (specifically - information system class model of the platform independent level) based on the knowledge (the description of the domain) stored in knowledge base. Of all design solutions, the class model is one of the major information system project solutions. Therefore this should efficiently optimize the design process of information system. In this paper you will discover the possible solution – proposed prototype of algorithm and pro-totype of knowledge base. Solution is realized on “MagicDraw UML” platform therefore it... [to full text]
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Barbosa, Lílian Paula Leitão. "Uma visão interacionista sociodiscursiva de leitura: por uma proposta interventiva para a aula de leitura no ensino básico." reponame:Repositório Institucional da UFC, 2016. http://www.repositorio.ufc.br/handle/riufc/21799.
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BARBOSA, Lílian Paula Leitão. Uma visão interacionista sociodiscursiva de leitura: por uma proposta interventiva para a aula de leitura no ensino básico. 2016. 266f. - Dissertação (Mestrado) – Universidade Federal do Ceará, Programa de Pós-graduação Profissional em Letras - PROFLETRAS, Fortaleza (CE), 2016.Submitted by Gustavo Daher (gdaherufc@hotmail.com) on 2017-01-23T15:21:10Z No. of bitstreams: 1 2016_dis_lplbarbosa.pdf: 1967492 bytes, checksum: be0cfac9c9fa0196a3cdce7b22f0fb3e (MD5)
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Made available in DSpace on 2017-01-25T16:46:57Z (GMT). No. of bitstreams: 1 2016_dis_lplbarbosa.pdf: 1967492 bytes, checksum: be0cfac9c9fa0196a3cdce7b22f0fb3e (MD5) Previous issue date: 2016
A leitura é o foco principal do nosso trabalho, pois ela tem um lugar de destaque nas práticas sociais, já que é, por meio dela, que os indivíduos se comunicam nos diversos setores da sociedade. Diante da importância da leitura para a formação de um leitor crítico e social, fica evidente a relevância da escola e do agir professoral do professor de Língua Portuguesa LM (Língua Materna) no processo de ensino e aprendizagem da leitura. Este estudo, então, proporcionou a análise dos últimos resultados das provas de larga escala, Spaece e Prova Brasil, aplicadas aos alunos do último ano do Ensino Fundamental II, dos anos de 2009 a 2013 no estado do Ceará, em que foram averiguados, apesar de uma melhora significativa, os baixos índices de proficiência em leitura. Para reverter esse quadro de ainda baixos resultados nas diversas avaliações internas e externas envolvendo leitura no nível básico de ensino, seria necessário que se elaborasse uma transposição didática inovadora, capaz de encorajar professores a novas descobertas e desafios. Verificando essa necessidade, propomos, então, uma intervenção por meio da metodologia da pesquisa-ação, “pesquisa associada a diversas formas de ação coletiva que é orientada em função da resolução de problemas ou de objetivos de transformação” (THIOLLENT, 2008), utilizando um modelo de sequência didática (DOLZ, 2010), voltada para o ensino da leitura para o nível básico, mais especificamente para o nono ano do Ensino fundamental II. Tratar-se-á de uma pesquisa qualitativa sobre a prática da leitura em sala de aula e do trabalho docente cujo foco será o próprio agir profissional do professor-pesquisador. O objetivo deste trabalho, portanto, é propor uma perspectiva interventiva mais atual para tornar essa aula de leitura mais eficiente para a aprendizagem e para o desenvolvimento da competência comunicativa dos discentes. Para conseguirmos tal objetivo, ancoramo-nos em estudos de Braggio (1992), quanto à concepção sócio-histórica ideológica de linguagem, tendo como base o quadro teórico do Interacionismo Sociodiscursivo - ISD (BRONCKART, 1999) e os modelos de aulas de leitura propostos por Cicurel (1991) e Leurquin (2014).
Cette étude a commencé à partir de l’analyse des derniers résultats des évaluations à large échelle, Spaece et Prova Brasil, appliqueés aux élèves de la dernière année de l’enseignement fondamental II, des années de 2009 à 2013, dans l’État du Ceará, dans laquelle des faibles niveaux de compétence en lecture ont été vérifiés, en dépit d’une amélioration significative. Pour changer cette situation de bas résultats dans les diverses évaluations internes et externes qui impliquent la lecture dans l’Éducation de base, il faut élaborer une transposition didactique innovante qui soit capable d’encourager des professeurs aux nouvelles découvertes et aux nouveaux défis. En raison de cette nécessité, on a proposé, alors, une intervention d’après la méthodologie de la recherche-action, définie comme « une recherche associée aux diverses façons d’action collective qui est orientée vers la résolution de problèmes ou d’objectifs de transformation » (THIOLLENT, 2008), en utilisant un modèle de séquence didactique (DOLZ, 2010) pour l’enseignement de la lecture dans l’éducation basique, particulièrement, dans la neuvième année de l’enseignement fondamental II. Il s’agit, de cette façon, d’une recherche qualitative à propos de la pratique de la lecture en classe et du travail enseignant, dont l’objectif est l’agir même professionnel de l’enseignant-chercheur. Ce travail a pour but, donc, de faire une analyse de la pratique actuelle de lecture dans l’enseignement basique et de proposer une perspective d’intervention plus actuelle pour rendre ce cours de lecture plus efficace pour l’apprentissage et pour le développement de la compétence comunicative des élèves. Pour réussir cet objectif, on se base sur les études de Braggio (1992), en ce qui concerne la conception socio-historique idélogique de langage ; sur le cadre théorique de l’Interaccionisme Socio-discursif - ISD - (BRONCKART, 1999) et sur les modèles de cours de lecture proposés par Cicurel (1991) et par Leurquin (2014).
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Ghavami, Maryam. "Antimalarial Agents: New Mechanisms of Actions for Old and New Drugs." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/96192.
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Worldwide, malaria is one of the deadliest diseases. In 2016 it sickened 216 million people and caused 445,000 deaths. In order to control the spread of this deadly diseases to human, we can either target the mosquito vector (Anopheles gambiae) or the parasite (Plasmodium falciparum). Due to recent emergence of resistance to current insecticides and antimalarial drugs there is a pressing need to discover and develop new agents that engage new targets in these organisms.
To circumvent the effect of resistance to pyrethroid insecticides on the efficacy of insecticide treated nets (ITNs), the use of acetylcholinesterase (AChE) inhibitors on ITNs has drawn attention. In the first project, we explored a small library of g- substituted oxoisoxazole- 2(3H)-carboxamides and isoxazol-3-yl carbamates, and nitriles as AChE inhibitors targeting wild- type (G3) and resistant (Akron) An. gambiae mosquito. In total 23 compounds were synthesized and evaluated. Both carbamates and carboximides with a 2-cyclopropylethyl side chain (1-87a and 1-88a) were extremely toxic to Akron mosquitos, yet these compounds did not exhibit appreciable selectivity between human and An. gambiae AChE. Unfortunately, none of the nitriles showed appreciable toxicity to G3 strain of the mosquitoes, nor did they inhibit An. gambiae AChE.
In the second project, conducted in collaboration with Professor Michael Klemba, we focused on the mode of action of an established antimalarial drug, Mefloquine (MQ). Dr. Klemba's recently developed amino acid efflux assay was used to determine the effect of MQ and its open-ring analogs on hemoglobin endocytosis and catabolism in P. falciparum-infected erythrocytes. In total 26 MQ analogs were synthesized and 18 were studied in depth to determine
their potency to inhibit leucine (Leu) efflux and parasite growth (SYBR Green). An excellent correlation (R2 = 0.98) over nearly 4 log units was seen for these 18 compounds in the two assays. These data are consistent with the hypothesis that the antimalarial action of these compounds principally derives from inhibition of hemoglobin endocytosis. After this observation, a number of photo-affinity probes were designed and synthesized in hopes of isolating the molecular target of MQ. These analogs are currently being used by Dr. Klemba in pull-down experiments.
In the third project, conducted in collaboration with Professor Belen Cassera, we sought to optimize a new antimalarial drug lead that would circumvent current resistance mechanisms. In Plasmodium parasites, the methylerythritol phosphate (MEP) pathway is known to be essential for its growth. This pathway is absent in humans, presenting the opportunity to develop potentially safe and effective therapeutic candidates. Previous work in the Cassera and Carlier lab had established that MMV008138 was the only compound in the Malaria Box that targeted the MEP pathway and that it was (1R,3S)-configured. My research expanded previous efforts in the Carlier group and produced synthesis of 73 analogs of MMV008138 (3-21a'1) that were tested for growth inhibition. These analogs featured variation at the A-, B-, C- and D-ring. In the process, a novel Pictet-Spengler ring expansion reaction of ortho-substituted acetphenones was discovered. The ring-expanded products were identified by means of 1D and 2D NMR experiments, HRMS, and X-ray crystallography. Among the 73 analogs prepared, four compounds showed similar growth inhibition potency to the lead 3-21a'1. In particular, the methoxyamide 3-80a, and the fluorinated A-ring analogs 3-124a, 3-124c and 3-124d all showed excellent (500-700 nM) growth IC50 values against P. falciparum. All four showed full rescue upon co-application of IPP (200 μM), confirming that they target the MEP pathway. ADME-Tox evaluation of these new analogs will soon be underway.PHD
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Hogg, James. "DESIGNING AN EXPERIENTIAL WEB-BASED LEARNING MODEL TO DELIVER THE ACQUISITION AND APPLICATION OF KNOWLEDGE TO HOSPITALITY EVENT." Doctoral diss., University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2121.
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ABSTRACT Most hospitality institutions have increasingly moved classes online but are concerned about migrating classes and instructional content online. The concern is most Web-based models are designed to deliver the acquisition of knowledge but lack the ability to transform that knowledge into applied career skills for practical use in the industry. The purpose of this study was to test a new Web-based instructional model. The model supported delivering both the acquisition and application of knowledge. Educators, researchers, and practitioners can utilize the new model to enhance the application of career skills and enhance organizational objectives by providing just-in-time training. The new Web-based instructional model can be delivered through multiple platforms including computers, electronic devices, wireless devices and mobile devices. The application of knowledge was delivered through experiential role-play exercises delivered live to the comparison group and virtual, inside Second Life, to the treatment group. An Analysis of Co-Variance (ANCOVA) revealed a significant difference between groups with higher application scores for the students who received the role-play live compared to virtual. In addition, an analysis was conducted to explore factors to consider when examining the cost effectiveness of Web-based instructional content. Factors determined to be important were developmental costs, delivery costs, and reusability of the Web-based instruction.Ph.D.
Department of Educational Research, Technology and Leadership
Education
Education PhD
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Garcia, Colin Monica. "Identification of a Potential Factor Affecting Graduation Rates in STEM for Hispanic Students at the University of North Texas, via Analysis of Nonfiction Science Books in Spanish Language for ELLs in the Dallas ISD Schools." Thesis, University of North Texas, 2016. https://digital.library.unt.edu/ark:/67531/metadc862785/.
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Latinos are the largest minority group in the U.S.; however despite the continuous growth of the Hispanic population, Latinos are severely underrepresented in STEM fields. One of the reasons that might explain why Latinos do not major in STEM is the way they encounter science curriculum in primary school. Students' limited proficiency in English may constrain their science achievement when instruction is delivered exclusively in English. A quantitative analysis with graduation rates in STEM from 2009 to 2014 at the University of North Texas was conducted, finding that there is a significant difference (p<0.05) in the number of bachelor's degrees in STEM between Hispanic, White, African American and other student populations. Interviews with teachers, librarians and publishing companies were performed to describe the limited science literature in Spanish at the Dallas ISD schools. Improving science literacy by teaching according to ELLs' linguistic skills and culture may lead to a better understanding of science curriculum throughout their education, which may translate into higher college graduation rates by Hispanic recipients in STEM.
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Barral, Carla Vanessa Ferreira. "A determinação de requisitos no sucesso de um projecto de desenvolvimento de sistemas de informação: um estudo de casos em Portugal." Master's thesis, Instituto Superior de Economia e Gestão, 2007. http://hdl.handle.net/10400.5/1299.
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Mestrado em Gestão de Sistemas de InformaçãoNo contexto actual, de grandes investimentos e ubiquidade dos SI, o seu sucesso revela-se da maior importância. Apesar de os executivos e investidores procurarem tendencialmente medir o sucesso a longo prazo, a análise detalhada dos resultados demonstrou que a maioria das dificuldades advém de problemas ocorridos durante a fase de projecto, devendo assim controlar-se o sucesso do projecto, no curto prazo, para permitir o início de um SI de sucesso. Neste sentido, o presente trabalho de investigação incide no sucesso do Projecto de Desenvolvimento de SI (PDSI), com base nas métricas de sucesso definidas por Markus et al (2000), para a fase de projecto: cumprimento dos custos, prazos e funcionalidades acordadas. A importância da determinação de requisitos para o sucesso de um PDSI é evidente para profissionais e investigadores de SI, e já discutida há alguns anos. Entender o porquê da dificuldade da actividade de determinação dos requisitos nas organizações e desenvolver caminhos para melhorar o processo e os seus resultados, é um desafio constante (Davidson, 2002). O presente estudo procura contribuir para a criação de um corpo de conhecimento sobre os requisitos e a sua ligação ao sucesso dos SI/TI, pelo sucesso de um PDSI. Este estudo pretende auxiliar as empresas e os gestores de negócio, a planear, gerir e criar condições para realizar a determinação de requisitos num PDSI, maximizando as suas probabilidades de sucesso. Para o cumprimento do objectivo proposto, após a revisão à literatura existente e adoptando a posição filosófica de realismo crítico, foi realizado um estudo exploratório de dois casos, nos quais se analisou a forma como foi feita a determinação de requisitos e qual a sua ligação ao sucesso de cada um dos PDSI. A recolha de dados foi efectuada através de entrevista, observação e análise documental, e a análise qualitativa de conteúdo, através da framework de análise teórico-empírica, desenvolvida com base na literatura revista. Este estudo procurou identificar e compreender problemas associados à determinação de requisitos, com potencial impacto no sucesso de um PDSI, e reconhecer medidas que mitiguem os problemas, minimizando o risco do seu insucesso.
In the current context of high Information Systems (IS) investments and ubiquity, the success of IS projects becomes of great importance. Although executives and investors seek to measure long term success, the detailed analysis of the results show that most difficulties result from problems occurred during the project phase. The present research focus on the success of the Information Systems Project Development (ISPD) based on success measures defined by Markus et al (2000), for the project phase: accomplishment of agreed costs, terms and functionalities. The importance of requirements determination for the success of ISPD is obvious for IS professionals and researchers. Understanding the reason of the difficulty of requirements determination activity in the organizations and developing ways to improve the process and its results, is a constant challenge (Davidson, 2002). The present study seeks to contribute to the creation of a body of knowledge on the requisites and its connection to the success of IS/IT, by studying the success of a ISPD. This study aims to help enterprises and business managers, planning, managing and creating conditions to carry out the requirements determination in a ISPD, maximizing the probabilities of success. For the proposed goal accomplishment, after reviewing the literature and adopting the philosophical position of critical realism, an exploratory study was carried on two cases. Data was collected through interviews, observation and document analysis. This study seeks to identify and understand problems related to requirements determination, with potential impact in the success of ISPD, and to recognize measures that minimize the risk of ISPD failure.
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Herrero, Pascual Cristina. "La Biblioteca de los Obispos (Murcia): historia y catálogo." Doctoral thesis, Universidad de Murcia, 1995. http://hdl.handle.net/10803/10915.
Full textAbstract:
Estudio de la Biblioteca de los Obispos (Murcia) centrado en el origen, formación de la colección y su evolución histórica. A partir del análisis de la estructura del libro en el siglo XVI, se ha creado una metodología, basada en la norma ISBD (A), para proceder a la descripción de obras de este siglo. A su vez, se ha diseñado y creado una base de datos para la realización del catálogo. Los resultados han sido: catálogo de impresos del siglo XV (incunables) y del siglo XVI de esta biblioteca, índices de colaboradores, lugares de impresión, impresores y materias.Study of the Library of the bishops of Murcia centered in the origin, formation of the collection and their historic evolution. Starting from the analysis of the structure of the book in the XVI century, a methodology has been created, based an opinion on the ISBD (A) norm, in order to proceed to the description of works of this century. To their time, it have been designed and created a base of data for the realization of the catalog. The outputs have been: catalog of forms of the XV century (incunabula) and of the XVI century of this library.
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Abreu-Tardelli, Lília Santos. "trabalhodoprofessor@chateducacional.com.br: aportes para compreender o trabalho do professor iniciante em EAD." Pontifícia Universidade Católica de São Paulo, 2006. https://tede2.pucsp.br/handle/handle/13799.
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Previous issue date: 2006-06-12Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
This research aims at contributing to the understanding of the work of a professor beginning to work in Distance Education, based on the analysis and interpretation of the representations about her acting in texts produced about and in the work situation in Distance Education, specifically in the context of the educational chat. In order to do that, we adopt the theory and methodology of sociodiscursive interactionism an interdisciplinary branch of Psychology which gives to acting and language an essential role in human development. Work being a way of acting, institutionally ruled and taking a central role in human development, we set out to investigate the relationship between language (constitutive of the human being) and work (central axis to understand present day society) in Distance Education within the different levels in which this work takes shape. With that in mind, we present a synthesis of the theoretical and methodological frame that we adopt and which involves: a) sociological issues the concept of work and technology and their mutual relations in contemporary society; b) issues about the status of actions and activities and their relations with language; c) issues related to the method of collection and analysis. Concerning the method of collection and analysis, we first present an a priori classification of the texts that constitute our data, and which allowed us to collect texts considered as (re-)configurating the acting of a first-time professor in an online course. After that, the categories of analysis are presented aiming at identifying the characteristics of these texts or of some of their segments in their general, organizational, enunciative and semantics aspects. The analyses of the texts aim at the understanding of the relations that this discursive or textual network bears with the work of a first-time professor in Distance Education, in his/her different ways of acting. Finally, the results of the analyses are presented, as well as the conclusions reached through the analyzed texts both in regard to the acting of the professor in a Distance Education environment and the methodological and theoretical frame adopted
Esta pesquisa tem como objetivo principal contribuir para a compreensão do trabalho do professor iniciante em Educação a Distância (EAD), por meio da análise e da interpretação das representações construídas sobre o agir nos textos produzidos sobre a e na situação de trabalho em EAD, especificamente no chamado chat educacional. Para isso, adotamos pressupostos teórico-metodológicos do interacionismo sociodiscursivo (ISD), vertente interdisciplinar da Psicologia, que atribui ao agir e à linguagem um papel fundamental no desenvolvimento humano. Sendo o trabalho uma forma de agir, regulado institucionalmente, e sendo ele um dos lugares centrais do desenvolvimento, propomo-nos a compreender as relações entre a linguagem (constitutiva do ser humano) e o trabalho (eixo central para a compreensão da sociedade atual) do professor em EAD nos diferentes níveis em que esse trabalho se configura. Para isso, apresentamos uma síntese dos pressupostos teórico-metodológicos que assumimos e que envolvem: a) questões de ordem mais sociológica conceito de trabalho e tecnologia e suas relações na sociedade contemporânea; b) questões sobre o estatuto das ações e das atividades e de suas relações com a linguagem; c) questões referentes ao método de coleta e ao método de análise. Em relação ao método de coleta e de análise, apresentamos, a priori, uma classificação dos textos que constituem nossos dados. Essa classificação nos permitiu coletar textos considerados como (re)configuradores do agir de um professor iniciante em um curso de EAD. Em seguida, apresentamos as categorias de análise, visando à identificação das características desses textos ou de alguns de seus segmentos, no seu aspecto genérico, organizacional, enunciativo e semântico. A análise dos textos visou sempre à compreensão da relação que essa rede discursiva ou textual mantém com o trabalho realizado pelo professor iniciante em EAD, nas suas diferentes formas de agir. Por fim, apresentamos os resultados das análises efetuadas e as conclusões a que nos permitiram chegar, referentes aos textos analisados tanto em relação ao agir do professor iniciante em ambiente de EAD quanto em relação ao quadro teórico-metodológico adotado