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1
Lee, Matthias S. "Biochemische und strukturelle Studien an IspG- und IspH-Proteinfamilien /." München : Verl. Dr. Hut, 2009. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=017315255&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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D'auria, Lucia. "Caractérisation biophysique et structurale de IspG et IspH (en complexe avec des inhibiteurs)." Electronic Thesis or Diss., Université Grenoble Alpes, 2023. http://www.theses.fr/2023GRALV116.
Abstract:
La résistance aux antibiotiques constitue un défi sanitaire mondial important. L'organisation mondiale de la santé la classant parmi les dix principales menaces pour la santé publique dans le monde ; d’où un besoin urgent de nouveaux anti-infectieux ciblant de nouvelles voies.Dans ce contexte, la voie du méthylerythritol phosphate (MEP) a une importance particulière. La voie MEP est composée de sept enzymes et est responsable de la biosynthèse des précurseurs des isoprénoïdes : le diphosphate d'isopentényle (IPP) et le diphosphate de diméthylallyle (DMAPP). Cette voie est totalement absente chez l'homme mais est essentielle pour des microorganismes tels que Mycobacterium tuberculosis (Mt), Plasmodium falciparum (Pf), Pseudomonas aeruginosa (Pa).Le but de ce projet était d'élucider les structures cristallographiques des deux dernières enzymes de la voie MEP (IspG et IspH) de trois pathogènes (P. aeruginosa, M. tuberculosis et P. falciparum) et ensuite, en combinant le criblage cristallographique aux rayons X de fragments et le criblage virtuel in silico de chimiothèques, d'identifier ou de concevoir de nouveaux inhibiteurs spécifiques de ces enzymes.En raison de la présence d'un cluster 4Fe-4S dans leurs sites actifs, toutes ces enzymes sont sensibles à l'oxygène et doivent être manipulées en boîte à gants dans des conditions anaérobies. La première partie de ce travail a consisté à produire et purifier chacune des six protéines en quantité suffisante aux études de cristallisation. Les trois IspH ainsi que Pa et MtIspG ont pu être purifiés.Les réactions catalysées par IspG et IspH dépendent d'un système donneur d'électrons. Chez Plasmodium, ce système est composé de deux protéines: la ferrédoxine (PfFd) et la ferrédoxine-réductase (PfFNR). L'obtention de ces deux protéines actives et en quantités suffisantes était une condition préalable à l'utilisation du système de réduction naturelle pour mesurer les activités enzymatiques de PfIspG et PfIspH. C'est pourquoi l'optimisation de l'expression et de la purification de PfFd et PfFNR a également été réalisée au cours de la première partie de ce projet. Les tests d'activité ont été réalisés avec succès pour PfIspH par le groupe du Dr. Myriam Seemann, nos collaborateurs à l'Université de Strasbourg. Ils ont également utilisé le système Plasmodium pour cribler différentes séries de composés chimiques in vitro.Le criblage des conditions de cristallisation a été réalisé en boite à gants avec toutes les protéines purifiées. Les cristaux obtenus ont été analysés à l’European Synchrotron Radiation Facility (ESRF). Les données recueillies ont permis d'élucider les premières structures cristallographiques de PaIspH et MtIspH à des résolutions de 1.5 Å et 2.8 Å, respectivement. Ces deux enzymes présentent le repliement typique de la famille IspH en trèfle à trois feuilles.PaIspH contient un cluster 3Fe-4S incomplet et une molécule de bicine provenant du tampon de cristallisation dans son site actif. La bicine interagit avec des résidus clés impliqués dans la liaison du substrat, mais n'a pas d'activité inhibitrice. Cependant, cela nous a permis d'obtenir des informations structurales sur les interactions possibles au sein du site actif, ce qui pourra aider à la conception de nouveaux inhibiteurs.Dans le cas de MtIspH, un déplacement du troisième domaine entraîne une ouverture inédite du site actif. Malgré cette ouverture, MtIspH présente un cluster 4Fe-4S. Cela peut s'expliquer par le fait que le déplacement du troisième domaine a rapproché le cluster de la thréonine 189, qui peut désormais se lier au fer apical et le stabiliser.Grâce à ces nouvelles structures, nous avons réalisé des criblages virtuels in silico de différentes chimiothèques. Certains composés identifiés in silico ainsi que de nouveaux inhibiteurs sélectionnés in vitro par nos collaborateurs de Strasbourg ont été utilisés pour des essais de co-cristallisationAntimicrobial resistance poses a significant global health challenge, with the World Health Organization ranking it among the top 10 global threats to public health worldwide. Hence, the urgent need for new anti-infectives targeting novel pathways.In this context, the Methylerythritol phosphate (MEP) pathway becomes particularly significant. The MEP pathway is composed of seven enzymes and is responsible for the biosynthesis of the two isoprenoids precursors: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). This pathway is completely absent in humans but is essential to pathogenic microorganisms such as Mycobacterium tuberculosis (Mt), Plasmodium falciparum (Pf), Pseudomonas aeruginosa (Pa).The aims of this project were to elucidate the crystallographic structures of the last two enzymes of the MEP pathway (IspG and IspH) from three different pathogens (P. aeruginosa, M. tuberculosis and P. falciparum) and by combining X-ray fragment screening and in silico virtual screening of chemical libraries, to identify or design new specific inhibitors of these enzymes.Due to the presence of a 4Fe-4S cluster in their active sites, all these targets are oxygen-sensitive enzymes that must be handled under anaerobic conditions using a glove-box. The first part of this work consisted in establishing a protocol for the production and purification of each of the six proteins in quantity suitable for crystallization studies. Pure proteins were obtained for all the IspH orthologues and for Pa and MtIspG.The reactions catalyzed by IspG and IspH are dependent on an electron donating system. For Plasmodium, this system is composed of two proteins: the ferredoxin (a 2Fe-2S cluster, PfFd) and the ferredoxin-reductase (a FAD dependent protein, PfFNR). Obtaining these two active proteins in sufficient quantities was necessary for using the natural reduction system for measuring the enzymatic activities of PfIspG and PfIspH. That’s why the optimization of the expression and purification of PfFd and PfFNR was also achieved during the first part of this project. The activity tests were performed successfully with PfIspH by the group of Dr. Myriam Seemann, our close collaborators at the University of Strasbourg. They also used the Plasmodium system to screen different series of chemical compounds in vitro.Crystallization screening under anaerobic conditions were performed for all the IspG and IspH proteins obtained. Several crystals were obtained and analyzed at the European Synchrotron Radiation Facility (ESRF). The collected data led to the elucidation of the first crystallographic structures of PaIspH and MtIspH at 1.5 Å and 2.8 Å resolution, respectively. Both enzymes show a three-leaf clover folding typical of the IspH family.PaIspH contains an incomplete 3Fe-4S cluster and a molecule of bicine coming from the crystallization buffer in its active site. The bicine is interacting with key residues involved in the substrate binding, but has no inhibitory activity. However, this has provided us structural information on possible interactions within the active site, which may help in the design of new inhibitors.For MtIspH, a shift in the third domain leads to a previously unseen opening of the active site. Surprisingly, despite this opening, MtIspH displays a 4Fe-4S cluster. This can be explained by the fact that the displacement of the third domain has brought the cluster closer to the threonine 189, which can bind and stabilize the apical iron.Some of the compounds identified in silico as well as new inhibitors selected in vitro by our collaborators in Strasbourg have been used for co-crystallization assays. The new structural information combined with the in silico docking analysis and the enzymatic activity assays, opens the door for new biophysical and structural studies of these fascinating enzymes that are targeted for the development of new anti-infectives
3
Zepeck, Ferdinand. "Charakterisierung der 1-Hydroxy-2-methyl-2-(E)-butenyl-4-diphosphat-Synthase (IspG-Protein)." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980363721.
4
Lauw, Susan. "Characterization and inhibition of the IspC, IspE and IspF proteins involved in the deoxyxylulose phosphate pathway of isoprenoids biosynthesis." kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/669162/669162.pdf.
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Santos, Juliete Vitorino dos. "Expressão e purificação da forma recombinante dos Inibidores de Serino Peptidase ISP1 e ISP2 de Leishmania infantum chagasi." reponame:Repositório Institucional da UFABC, 2017.
Abstract:
Orientadora: Profª Drª Márcia Aparecida SperançaDissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biossistemas, 2017.
A leishmaniose visceral, causada pelos parasitas das espécies Leishmania infantum e Leishmania donovani, do Velho Mundo, e pela Leishmania infantum chagasi, do Novo Mundo, é uma doença infecciosa e letal se não for tratada. O número de casos desta doença está aumentando no Estado de São Paulo. Uma vez diagnosticada, o tratamento para a leishmaniose visceral tem efeitos colaterais importantes, além da ocorrência de parasitas resistentes aos medicamentos disponíveis. Sabe-se que algumas peptidases desempenham um papel importante na fisiologia e doença causada por parasitas do género Leishmania. A inibição específica destas enzimas pode constituir uma importante estratégia para a produção de potentes agentes antiparasitários. Em bactérias E. coli, inibidores de serino peptidases (ISPs) denominados ecotinas, têm sido descritos, sendo também identificados em espécies de Leishmania. A caracterização funcional da ISP1 e ISP2 de L. major mostrou o seu papel na formação de flagelo de promastigotas e na inibição da elastase de neutrófilos de hospedeiro vertebrado, respectivamente. Portanto, os objetivos deste projeto são a expressão e a purificação das proteínas ISP1 e ISP2 de L. i. chagasi (LcISP1 e LcISP2) recombinantes. A amplificação das sequências que codificam as LcISP1 e LcISP2 foi realizada por PCR a partir do DNA genômico, de L. i. chagasi extraído de uma estirpe de referência cedida pelo Laboratório Nacional de Referência de Espécies de Leishmania da Fiocruz, Rio de Janeiro. Os fragmentos de PCR foram clonados no vetor de expressão bacteriano pET28a e as proteínas recombinantes LcISP2 e LcISP1 foram obtidas na fração solúvel do extrato proteico bacteriano. Após expressão das proteínas recombinantes, elas foram purificadas por cromatografia de afinidade em níquel.
Visceral leishmaniasis, caused by the Old World parasites species Leishmania infantum and Leishmania donovani, and by the New World Leishmania infantum chagasi, is an infectious and lethal disease, if untreated. The number of cases of this disease is increasing in the State of São Paulo. Once diagnosed, treatment for visceral leishmaniasis has important side effects, besides occurrence of parasites resistant to the available drugs. It is known that some peptidases play an important role in physiology and disease caused by parasites of the genus Leishmania. The specific inhibition of these enzymes may constitute an important strategy for producing potent antiparasitic agents. In bacteria E. coli, inhibitors of serine peptidases (ISPs) called ecotins, have been described, being also identified in Leishmania species. Characterization of genes encoding ISP1 and ISP2 of L. major, showed its role in the promastigote flagellum formation and in the inhibition of vertebrate host neutrophil elastase, respectively. Therefore, the aims of this project are to produce L. i. chagasi ISP1 (LcISP1) and ISP2 (LcISP2) recombinant forms and to evaluate the its biochemical activity. Amplification of the LcISP1 and LcISP2 encoding sequences were performed by PCR from L. i. chagasi DNA extracted from a reference strain obtained from the Leishmania collection of the Leishmania National Reference Laboratory of the Instituto Oswaldo Cruz. PCR fragments were cloned into the pET28a bacterial expression vector and the recombinant LcISP1 and LcISP2 proteins were present in soluble bacterial extract fraction. After purification by niquel affinity chromatography, recombinant LcISP1 and LcISP2 proteins e were tested for biochemical activity.
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Nie, Weiwei. "Plano de marketing – ISEG." Master's thesis, Instituto Superior de Economia e Gestão, 2018. http://hdl.handle.net/10400.5/16570.
Abstract:
Mestrado em MarketingO ISEG é relativamente pouco conhecido, no geral, devido às seguintes principais vertentes: a comunicação no mercado chinês e os programas de cooperação com as IES na China. Na fase inicial de exploração do mercado chinês, é fundamental compreendê-lo, assim como conhecer o perfil dos alunos chineses, o que inclui a sua família. O presente projeto tem como principal objetivo explorar o perfil dos alunos chineses e a perceção dos mesmos do contexto português, através de dados secundários e do questionário destinado a alunos que já frequentam cursos de licenciatura, mestrado e doutoramento em Portugal. De modo a perceber os principais pontos fortes e fracos, realiza-se uma análise de concorrência externa e interna. A partir desta análise, identificam-se as partes que se devem melhorar, tais como o aumento de oferta de cursos lecionados em inglês, e a comunicação e a cooperação com as instituições de ensino superior na China. Assim, o plano de marketing desenvolvido apresenta diversas ações e estratégias, que visam melhorar a imagem do ISEG no mercado chinês, aumentar a sua notoriedade, incrementar o número das inscrições de alunos chineses, etc.
For chineses students, the general knowledge for ISEG's is relatively low, mainly due to the two aspects: communication in the Chinese market and cooperation programs with HEIs in China. In the initial phase of exploring Chinese market, it is crucial for ISEG to understand the Chinese market and the profile of Chinese students, even their parents. The main objetivo for the present project is to explore the profile of Chinese students and their perception in terms of Portugal, through secondary data and the questionnaire for chinese students who are already attending undergraduate, masters and doctorate courses in Portugal. In order to understand the main strengths and weaknesses of ISEG compared with its competitors external and internal, a competition analysis is carried out. Based on that, we find out the main parts to be improved, such as: increase the number of courses taught in English, the communication and cooperation with higher education institutions in China. As a result, the Marketing Plan developed presents several actions and strategies, aimed at improving the image of ISEG in the Chinese market, increase its notoriety, and the enrollment of Chinese students, etc.
info:eu-repo/semantics/publishedVersion
7
Cull, Dominic. "ISPs IN THE MIDDLE." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/4595.
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Ulfskans, Niklas, and Christian Thorell. "ISPS : Vakten i Göteborgs oljehamn." Thesis, University of Kalmar, Kalmar Maritime Academy, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-241.
Abstract:
Med anledning av ISPS- kodens inträdande 2004 och personliga erfarenheter från fartyg och skyddsvaktsarbete har vi valt att fördjupa oss i ämnet portvaktens arbetsuppgifter. Vad vi har observerat sedan tidigare är att den allmänna uppfattningen bland ombordanställda är att portvakten är i vägen och det tar lång tid att komma till sin arbetsplats på fartyget.
Detta är en deskriptiv uppsats, där vi gjort en kvalitativ studie som bygger på intervju med vaktpersonal. Intervjun är sedan jämförd med de regler som finns för vakten i porten. Vi har avgränsat oss till att undersöka Göteborgs hamn, då denna var först i Europa att införa ISPS. Vi har intervjuat Magnus Rosenqvist, gruppchef på G4S i Göteborgs hamn. Detta har vi sedan jämfört med vad sjöbefälsstudenter på Högskolan i Kalmar har för erfarenheter och uppfattningar.
Vakten ansvarar för tillträdet till hamnområdet. Anledningen varför kontrollerna är så höga är för att upprätthålla hamnskyddet, inte fartygsskyddet. Vakten har samma ISPS- utbildning som resterande hamnpersonal, den utbildning en väktare måste inneha, men i Göteborgs hamn måste man dessutom vara skyddsvakt.
In connection with the ISPS- code's arising in 2004 and personal experiences from ships and security guarding, we have selected to deepen ourselves in the matter the gatekeeper’s duties. We have observed already that the general view among the vessel’s apployes, that the gatekeeper is in the way and it takes a long time to get to the workplace onboard the ship.
This is a descriptive essay, where we have done a qualitative study that builds on interview with local security personnel. The interview is then compared with the rules that are for the security guard in the gate. We have delimited ourselves to examining Gothenburg's port, because this is the first port in Europe to introduce the ISPS- code. We have interviewed Magnus Rosenqvist, squad commander at G4S in Gothenburg’s port. This result is then compared with the experiences and thoughts of students at Kalmar Maritime Academy.
The security guards are responsible for the access to the port area. The reason why the controls are so high is in order to maintain the port’s protection, not the ship’s protection. The security guard has the same ISPS education that all port personnel have, the education a general security guard must hold, but in Gothenburg’s port a security guard also must have a “skyddsvakt’s” education.
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Kunfermann, Andrea Christiana [Verfasser], Michael [Akademischer Betreuer] Groll, and Thomas [Akademischer Betreuer] Kiefhaber. "Structural and functional characterization of the non-mevalonate pathway enzymes IspC and IspD in complex with natural and synthetic ligands / Andrea Christiana Kunfermann. Gutachter: Michael Groll ; Thomas Kiefhaber. Betreuer: Michael Groll." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/104867732X/34.
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Chow, Alex. "Incompressible SPH (ISPH) on the GPU." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/incompressible-sph-isph-on-the-gpu(b569f890-78f1-42c2-b9d4-7082b45f45c8).html.
Abstract:
Incompressible free-surface flows involving highly complex and violent phenomena are of great importance to the engineering industry. Applications such as breaking-wave impacts, fluid-structure interaction, and sloshing tanks demand an accurate and noise-free pressure field, and require large-scale simulations involving millions of computation points. This thesis addresses the need with the novel use of a graphics processing unit (GPU) to accelerate the incompressible smoothed particle hydrodynamics (ISPH) method for highly non-linear and violent free-surface flows using millions of particles in three dimensions. Compared to other simulation techniques, ISPH is robust in predicting a highly accurate pressure field, through the solution of a pressure Poisson equation (PPE), whilst capturing the complex behaviour of violent free-surface flows. However, for large-scale engineering applications the solution of extremely large PPE matrix systems on a GPU presents multiple challenges: constructing a PPE matrix every time step on the GPU for moving particles, overcoming the GPU memory limitations, establishing a robust and accurate ISPH solid boundary condition suitable for parallel processing on the GPU, and exploiting fast linear algebra GPU libraries. A new GPU-accelerated ISPH algorithm is presented by converting the highly optimised weakly-compressible SPH (WCSPH) code DualSPHysics and combining it with the open-source ViennaCL linear algebra library for fast solutions of the ISPH PPE. The challenges are addressed with new methodologies: a parallel GPU algorithm for population of the PPE matrix, mixed precision storage and computation, and extension of an existing WCSPH boundary treatment for ISPH. Taking advantage of a GPU-based algebraic multigrid preconditioner for solving the PPE matrix required modification for ISPH's Lagrangian particle system. The new GPU-accelerated ISPH solver, Incompressible-DualSPHysics, is validated through a variety of demanding test cases and shown to achieve speed ups of up to 25.3 times and 8.1 times compared to single and 16-threaded CPU computations respectively. The influence of free-surface fragmentation on the PPE matrix solution time with different preconditioners is also investigated. A profiling study shows the new code to concentrate the GPU's processing power on solving the PPE. Finally, a real-engineering 3-D application of breaking focused-wave impacting a surface-piercing cylindrical column is simulated with ISPH for the first time. Extensions to the numerical model are presented to enhance the accuracy of simulating wave-structure impact. Simulations involving over 5 million particles show agreement with experimental data. The runtimes are similar to volume-of-fluid and particle-in-cell solvers running on 8 and 80 processors respectively. The 3-D model enables post-processing analysis of the wave mechanics around the cylinder. This study provides a substantial step for ISPH. Incompressible-DualSPHysics achieves resolutions previously too impractical for a single device allowing for the simulation of many industrial free-surface hydrodynamic applications.
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Mário, Lins Galdino Sérgio. "ISPN: Modelagem e avaliação estocástica intervalar." Universidade Federal de Pernambuco, 2009. https://repositorio.ufpe.br/handle/123456789/1444.
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Previous issue date: 2009O estudo de sistemas através de modelos é baseado em abstrações do mundo real. Portanto, os cálculos resultantes devem ser interpretados com cautela. Quando incertezas ou variabilidades estão associadas com os parâmetros do sistema, a caracterização pontual dos parâmetros pode ser inadequada. As incertezas podem estar associadas a parâmetros que não são conhecidos antecipadamente, especialmente em estágios iniciais de projetos de sistemas. Um dos objetivos deste trabalho é a concepção do formalismo ISPN para análise quantitativa desses sistemas. Para alcançar este objetivo, desenvolveu-se a fundamentação teórica ISPN e foram adaptados algoritmos apropriados para análise dos modelos. A análise intervalar foi usada como método de análise do estado estacionário dos modelos ISPN, nos quais as taxas das transições exponenciais e os pesos das transições imediatas são intervalos. A ISPN é aplicada principalmente para modelar as situações em que os dados de entrada estão num determinado nível da exatidão. As incertezas das taxas são especificadas através de intervalos. Este ambiente de modelagem fornece uma maneira para formalizar e estudar os problemas relacionados à presença das incertezas. Tais incertezas incluem os erros dos dados que ocorrem durante os processos de medida e os erros de arredondamento gerados durante cálculos. O modelo proposto e o método de análise relacionado permitem que a análise de desempenho seja realizada, considerando variações simultâneas nos parâmetros. Os métodos intervalares foram aplicados na estimativa exterior do conjunto solução para sistemas de equações lineares intervalares resolvidas pela aritmética intervalar clássica e pela aritmética de Kaucher dentro do ambiente do MATLAB toolbox INTLAB. Usamos ISPN como uma ferramenta de alto nível para modelagem e análise. O poder de modelagem ISPN foi avaliado em diversos estudos de caso apresentados
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Wei, Weixiao. "ISP copyright liability : towards an enhanced Chinese ISP copyright liability regime." Thesis, University of Strathclyde, 2009. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=11856.
Abstract:
ISP copyright liability for copyright infringement over the Internet is a now widely adopted approach for tackling extensive online copyright piracy in various jurisdictions. However, in China, the inconsistent ISP knowledge standard and the lack of peer-to-peer file-sharing liability provisions in the existing legal framework are among the factors that impede effective copyright law enforcement on the Internet. The adoption of a broad knowledge standard and its application in case law, both in the U.S. and Germany, which have great influence on a Chinese ISP copyright liability system, are discussed along with a similar knowledge standard provided by the Chinese Online Copyright Regulations and its application to ultimately show the need of a broad knowledge standard in a Chinese ISP copyright liability system. As for the liability issues over peer-to-peer file-sharing networks, analysis of several prominent cases and the enacted or proposed legislation in this regard in an international context sheds light on the importance of a filtering mandate in effectively deterring copyright piracy. In a Chinese context, the absence of peer-to-peer file-sharing liability legislation and the inadequacy of the applied provisions in the existing legislation entail the examination of the need and the possibility of the mandatory use of filters in a Chinese ISP copyright liability system. For an enhanced Chinese ISP copyright liability regime, the thesis concludes with two recommendations that a broad ISP knowledge standard should be retained in the Chinese ISP copyright liability system and a filtering mandate is needed and should be legislated for efforts against widespread unlawful peer-to-peer file-sharing.
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Cheema, Ansar Zaman, and Imran Ullah Saqib. "Collaborating ISPs Supporting Various Real-Time Services." Thesis, Halmstad University, School of Information Science, Computer and Electrical Engineering (IDE), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-4902.
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These days, internet service providers (ISPs) face the challenge about how to increase profitability while hey must ensure a good quality service at the same time and scale up their network. The study involves previous research papers. On the bases of those papers,the comparison is made between different alternatives. The purpose on this study is to find a solution that combines different methods and configurations about how several ISPs could cooperate. Its implementation includes how different ISPs can configure their networks to cooperate on service provision supporting various real-time services.
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Martins, Marta Calisto. "Proposta de Balanced Scorecard para o ISEG." Master's thesis, Instituto Superior de Economia e Gestão, 2012. http://hdl.handle.net/10400.5/10455.
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Mestrado em Contabilidade, Fiscalidade e Finanças EmpresariaisO contexto de mudança constante em que a sociedade se insere, acompanhado por um ambiente extremamente competitivo, pelo elevado grau de exigência dos mercados e evolução das novas tecnologias de informação, impõe a qualquer organização um sistema de controlo de gestão eficaz e eficiente. Em suma, é necessário avaliar em que medida é que os objectivos estratégicos delineados na missão e visão das organizações estão a ser alcançados. O balanced scorecard (BSC) surge assim, na década de 90, como um sistema de avaliação de desempenho que fornece uma visão integrada e global do desempenho, uma vez que se baseia num conjunto, não só de indicadores de carácter financeiro, mas também de carácter não financeiro, para medir o desempenho da organização, ajudando na implementação e comunicação da estratégia, através da clarificação da missão e visão das organizações. O BSC inicialmente foi aplicado ao sector privado, no entanto na segunda metade da década de 90, devido ao sucesso que este sistema de avaliação de desempenho revelou, passou a ser implementado nos serviços públicos. O modelo apresentado inicialmente necessitou de sofrer algumas adaptações devido ao seu objectivo principal ser o de criar valor para os cidadãos, não se centrando no lucro como no sector privado. O presente estudo tem como objectivo apresentar uma proposta do modelo BSC, adaptado ao ISEG. Neste estudo é assim apresentado uma proposta para o mapa estratégico do ISEG com os objectivos estratégicos, bem como as esperadas relações de causa-efeito entre os diversos objectivos e ainda os respectivos indicadores.
Due to the constant change that society is suffering, mainly the highly competitive environment, the high demand of markets and the constant evolution of new information technologies, all organizations need to implement an efficient and effective management system control. It is fundamental to evaluate if the strategic objectives established in the mission and vision of the organizations are being achieved. The balanced scorecard (BSC) appeared in the 90s, as a performance measurement system that provides an integrated and global view of organizational performance and it is based on a set of, not only financial metrics, but also non-financial metrics, to measure the results of the organizations, helping in the implementation and communication of the strategy by clarifying the mission and vision of the organizations. The BSC was initially applied to the private sector, however in the second half of the 90s, due to the success that this system of performance measurement revealed, was implemented in the public sector. The model presented initially required some adjustments, because the main objective of these organizations is to create value for the citizens, rather than focusing on profit, like in the private sector. The present study aims to present a proposal of the BSC model, adapted to ISEG. In this study is therefore presented a proposal of the strategy map of ISEG with the strategic objectives, as well as the expected cause-effect relationships between the various objectives and the respective metrics.
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Wang, Yukai <1987>. "ISPs’ Duty of Care in Copyright Infringement." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/8912/1/WANG_YUKAI_tesi.pdf.
Abstract:
This dissertation discussed the ISP’s duty of care in copyright infringement. The duty hereon refers to the ISP’s legal obligation to take care of the influence of the provided service on the protection of others’ copyright. The duty is divided into three sub-categories: the duty of general prevention, the duty of assistance in specific infringement and the duty to deal with repeated infringement. In order to provide a comprehensive and systematic explanation of the duty, four main aspects are logically discussed: the background, the status quo, the justification, and the specific application.
In addition to the traditional mechanism of notice and take down, it is asserted that the ISP should play a more active role in dealing with the users’ online infringement. In particular, the ISP should be imposed on a legal obligation to keep neutral actually and to have general control of the infringing activities through their service. Thereby, the application of the filtering technologies should not be refused as a whole, but should be limited from the perspective of the purpose, the scope as well as the efficacy. Accordingly, the fundamental orientation of the Proposal for a Directive of the European Parliament and of the Council on Copyright in the Digital Single Market is supported by this dissertation. At the same time, it is recommended to adopt the application of the duty of general prevention on the ISPs providing platforms instead of recognizing the service itself as communicating to the public.
16
Wahlén, Niklas. "On ISP Friendliness: Introducing an ISP-Friendly Peer-to-Peer Live Streaming System." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-100337.
Abstract:
The various capabilities provided by the Internet have attracted a large amount of Internet-based applications over the last decades. Many services that previously only used other means of communication are now also deployed on the Internet. As the content in the communication becomes richer, the bandwidth required to communicate it increases. In the case of delivering audiovisual content over the Internet, a significant amount of bandwidth is required to send the content to a single recipient, and increases rapidly for each additional recipient. To be able to provide scalable, Internet-based systems for video content delivery, researchers and companies have begun to focus on peer-to-peer-based approaches, meaning participants collaborating and contributing their bandwidth to assure content delivery to all others. This thesis proposes a design for a peer-to-peer system for delivery of live video, and provides simulation results for an implementation of the design. The design targets some of the current issues of peer-to-peer systems – mainly that of providing friendliness towards Internet Service Providers (ISPs). Peer-to-peer systems generate considerable amounts of traffic, which is often sent between peers located in different ISPs, even when data is available at a peer in the same ISP as the recipient. This creates problems for ISPs as they often have to pay other ISPs for data sent over cross-ISP connections, and because congestion can occur in the ISPs gateways to the rest of the Internet – the problems increasing with the number of ISPs that the traffic has to go through. This has forced some ISPs to limit or block peer-to-peer traffic completely. The system designed in this thesis uses a gossip-based peer-to-peer protocol for content dissemination, and to minimize cross-ISP traffic, the thesis proposes that peers should choose peers closer in the network topology to connect to. This can be achieved by creating a database composed of ISPs and the distance between them, which is consulted every time a new connection is to be created. The database is small enough to be stored locally at each peer. As long as a peer is able to deliver a clear stream it will only connect to close peers, however should the close peers not be able to provide data at a sufficient rate, the peer will request random peers in the system to also provide it with data. Evaluation of the system in various simulation scenarios shows that it operates well in a constrained environment as well as during peer failures. The evaluation also shows that it is possible to have high clustering of peers and still deliver a clear stream to all of them, as long as a few random connections are allowed to be created when close neighbors can’t provide a suffi cient download rate. Comparing the use of biased neighbor selection to random selection, traffic between ISPs is efficiently reduced in the overall system, the portion of traffic exchanged between peers in the same ISP experience a ten times increase or more in most scenarios, and in larger ISPs that contain many peers, 75% of all traffic is exchanged between peers within the ISP. Thus the design presented in this thesis can be recommended to developers and content providers that are looking to increase ISP friendliness in their existing or future peer-to-peer applications.De många möjligheter som Internet medför har gett upphov till ett stort antal Internet-baserade tjänster de senaste decennierna. Flertalet tjänster som tidigare endast fanns tillgängliga via andra kommunikationskanaler är numera också möjliga att nå via Internet. I och med att informationen som skall skickas via olika tjänster ökar så ökar också kraven på bandbredd, och för att kunna leverera video krävs en ansenlig bandbredd. Bandbredden som krävs av den som levererar videon ökar dessutom snabbt i takt med antalet mottagare av den. För att kunna skapa Internet-baserade tjänster för video som tillåter ett större antal användare har forskare och företag börjat använda peer- to-peer-baserade lösningar, där användarna av tjänsten samarbetar och bidrar med deras egen bandbredd för att göra det möjligt för samtliga användare att ta emot videon. Detta arbete beskriver hur ett peer-to-peer-system för live-video kan utformas, och tillhandahåller resultat från simulationer med en implementation av systemet. Det huvudsakliga målet med systemets design är att minska bördan som peer-to-peer-system vanligen utgör för internetleverantörer. Denna typ av system genererar ofta stora mängder data, som i de flesta fall skickas mellan användare som befinner sig i nätverk tillhörande olika internetleverantörer, trots att samma data ofta finns tillgänglig på närmare håll – det vill säga hos användare som tillhör samma internetleverantör som mottagaren. Detta är ett problem för internetleverantörerna eftersom de ofta behöver betala för trafik som lämnar eller går till deras nätverk. Utöver detta så kan de anslutningar som existerar mellan dessa nätverk inte alltid klara sådana mängder trafik, vilket gör att alla användare av de anslutningarna blir lidande. Detta har lett till att vissa internetleverantörer begränsar eller inte tillåter peer-to-peer-trafik överhuvudtaget. Systemet som utformats i detta arbete bygger på gossiping (ryktesspridning) för att förse användare med videoströmmen. För att minimera mängden trafik som skickas mellan användare hos olika internetleverantörer så jämför användarna avståndet i nätverkstopologin till andra användare och skapar bara anslutningar till de som befinner sig närmast. Avståndet mellan två internetleverantörer utgörs av antalet anslutningar mellan två internetleverantörers nätverk som måste passeras på vägen. Dessa avstånd är lagrade i en databas som finns lokalt hos varje användare. Så länge en användare kan se en videoström utan störningar så laddas den endast ner från närbelägna användare, men skulle dessa inte kunna tillgodose användaren med tillräcklig datahastighet så kommer andra, slumpmässigt utvalda, också att kontaktas för att bidra med delar av videoströmmen till denna användare. I den utvärdering av systemet som gjorts så har det visat sig fungera väl när tillgängliga resurser som bandbredd och tillförlitligheten i det fysiska nätverket är begränsade, samt under svåra förhållanden som när en stor del av användarna lämnar systemet samtidigt. Utvärderingen visar också att användarupplevelsen inte påverkas av förändringen som det innebär att föredra kommunikation med närbelägna användare, så länge några få slumpmässiga anslutningar är tillåtna i de fall då användare i närheten inte kan tillhandahålla tillräcklig datahastighet. Jämfört med att välja alla kommunikationspartners slumpmässigt så minskar tillvägagångssättet i detta arbete effektivt trafiken mellan olika internetleverantörer både sett till hela systemet och i enskilda nätverk—andelen trafik som utbyts mellan användare tillhörande samma internetleverantör blir i de flesta fall tio gånger större—och i stora nätverk som innehåller många användare så utgör trafik mellan dess användare 75 % av all systemets trafik i detta nätverk. Den design som utformats i detta arbete kan därför rekommenderas till utvecklare och tillhandahållare av både existerande och framtida tjänster som använder peer-to-peer-teknik, och som är intresserade av att minska belastningen som deras system utgör för internetleverantörer.
17
Gomes, Ana Isabel Fidalgo. "Reatribuição de salas em horários escolares no ISEG." Master's thesis, Instituto Superior de Economia e Gestão, 2018. http://hdl.handle.net/10400.5/17189.
Abstract:
Mestrado em Métodos Quantitativos para a Decisão Económica e EmpresarialO presente trabalho tem como objetivo colmatar a necessidade de otimizar os horários dos alunos de licenciatura do ISEG, para que estes realizem o mínimo de deslocações de salas no mesmo dia. Assim, o desafio proposto consiste em resolver este problema utilizando o conhecimento adquirido ao longo do mestrado. Apesar de a Secretaria das Licenciaturas utilizar um programa para a elaboração dos horários das licenciaturas, o Bullet Education Scheduling and Timetabling, este não otimiza as deslocações dos alunos da mesma turma entre as várias salas de aula. Espera-se que a implementação computacional desenvolvida no âmbito do presente TFM auxilie a Secretaria das Licenciaturas na elaboração dos horários. Desta forma, a secretaria não necessitará de despender tempo a fazer alterações de salas, processo esse que atualmente é feito manualmente. Assim, será facilitado não só o trabalho da secretaria, como melhorado o dia-a-dia dos alunos e também o dos funcionários desta instituição. Através do Excel e de programação em VBA procede-se à leitura dos dados fornecidos pela Secretaria das Licenciaturas. Após a leitura dos dados, é aplicada uma Heurística de Trocas sobre os mesmos que permite a criação de horários de melhor qualidade, no que a deslocações dos alunos das várias licenciaturas do ISEG diz respeito. Assim, após a aplicação da heurística, obtêm-se alterações em 14 dos 79 horários analisados, sendo que o tempo de execução do programa comparado com o processo manual é relativamente baixo, demorando menos de cinco minutos.
This work aims at filling the need of optimize the timetables of ISEG?s bachelor students, so that students make less movements from room to room on the same day. Therefore, the challenge that was proposed to me consists in solving this issue using the knowledge acquired during the master. Although the bachelors' secretariat uses a program for the preparation of undergraduate timetables, the Bullet Education Scheduling and Timetabling (BEST), it does not optimize the movement of students of the same class between their successive classrooms. It is expected that the computational implementation developed in the scope of the present masters degree work will assist the secretariat in the preparation of the schedules. As a result, the secretariat will not need to spend time making room changes, a process that is currently done manually. Not only the work of the bachelor's degree secretariat, but also the day-to-day work of the students, staff and teachers of this institution will be improved. Through Excel and VBA programming, the data provided by the bachelor's degree secretariat is read. After reading the data, a heuristic is applied to produce timetables of better quality, regarding the movements of the undergraduate students of ISEG. After the application of the heuristic, we obtain changes in 14 of the 79 timetables analyzed, and the execution time of the program is significantly low, comparing with the manual process, taking less than five minutes.
info:eu-repo/semantics/publishedVersion
18
Salas, Peña Carlo Anthony Marcos Javier. "Planeamiento estratégico para la empresa Iseg Perú S.A.C." Master's thesis, Pontificia Universidad Católica del Perú, 2019. http://hdl.handle.net/20.500.12404/15072.
Abstract:
El plan estratégico de ISEG PERÚ S.A.C. desarrollado en el presente documento, se
realizó identificando las estrategias que la compañía debe implementar para generar un
posicionamiento que le permita aprovechar las condiciones del mercado en su sector y
desarrollar sus actividades en el marco de su visión, propósito, misión y valores. ISEG PERÚ
S.A.C. es una compañía dedicada a las actividades de prestación de "Servicios
Complementarios" de Seguridad y Vigilancia Privada, con operaciones en las principales
ciudades del Perú desde el año 2009.
Actualmente, debido al incremento de la inseguridad ciudadana los clientes se han
vuelto más exigentes al momento de elegir una empresa de seguridad y vigilancia. La
demanda de servicios de seguridad privada se ha incrementado; una prueba de ello, son las
denuncias por comisión del delito las cuales se han incrementado en los últimos años: el 70 %
de las empresas invierten en agentes de seguridad.
De acuerdo al contexto y del análisis efectuado a ISEG PERÚ S.A.C., la empresa
debe crecer y posicionarse en el país, y para lograrlo debe aplicar acciones enfocadas en la
optimización de costos y asociadas a estrategias específicas y de diversificación, debiendo
invertir en infraestructura física y tecnológica, así como mejorar la calidad del servicio y
garantizar su sostenibilidad en el tiempo.
La metodología aplicada es la del Proceso Estratégico planteado por D´Alessio (2013)
en su libro El proceso estratégico: un enfoque de gerencia, el cual tiene un desarrollo
sistémico y secuencial. Se comienza presentando la situación actual de la empresa,
procediendo a analizar la situación externa e interna de la empresa. Con estos datos se define
la visión para el año 2024, junto con su misión, de donde se derivan los objetivos de largo
plazo. Luego, se presentan las estrategias para llegar a la visión y se describe el proceso de
evaluación y control estratégico. Finalmente, para asegurar la implementación exitosa del plan estratégico, se han
propuesto indicadores financieros, de clientes, de procesos internos y de aprendizaje,
dispuestos en el tablero de control balanceado, a través de los cuales se medirá el avance en
la ejecución de los objetivos a corto plazo definidos, los mismos que permitirán el logro de
los objetivos de largo plazo, y con ello, alcanzar la visión de ISEG PERÚ S.A.C. al 2024.The strategic plan of ISEG PERÚ S.A.C. developed in this document was made by identifying the strategies that the company must implement to generate a positioning that allows it to take advantage of the market conditions in its sector and develop its activities within the framework of its vision, purpose, mission and values. ISEG PERÚ S.A.C. is a company dedicated to the activities of provision of "Complementary Services" of Security and Private Surveillance, with operations in the main cities of Peru since 2009. Currently, due to the increase in citizen insecurity, customers have become more demanding when choosing a security and surveillance company. The demand for private security services has increased, proof of which are the complaints of crime that have increased in recent years, 70 % of companies invest in security agents. According to the context and the analysis made to ISEG PERÚ S.A.C., the company must grow and position itself in the country, and to achieve this it must apply actions focused on cost optimization, and associated with specific strategies and diversification, having to invest in physical infrastructure and technological, as well as improving the quality of the service and guaranteeing its sustainability over time. The methodology used is the Strategic Process raised by D'Alessio (2013) in his book The Strategic Process, management approach, which has a systemic and sequential development. It begins by presenting the current situation of the company, proceeding to analyze the external and internal situation of the company. With these data, the vision for the year 2024 is defined, together with its mission, from which the long-term objectives are derived. Then, the strategies to reach the vision are presented and the process of evaluation and strategic control is described. Finally, to ensure the successful implementation of the Strategic Plan, financial, client, internal process and learning indicators have been proposed, arranged in the Balanced Control Board, through which the progress will be measured in the execution of the defined short-term objectives, which will allow the achievement of the long-term objectives, and with it, achieve the vision of ISEG PERÚ S.A.C. to 2024.
Tesis
19
H, Fruchter Nathaniel. "Enhancing ISP-consumer security notifications." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122916.
Abstract:
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Thesis: S.M. in Technology and Policy, Massachusetts Institute of Technology, School of Engineering, Institute for Data, Systems, and Society, Technology and Policy Program, 2019
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 79-85).
Security notification schemes hold great promise for improving both consumer cybersecurity and general network health as malware and other sources of malicious activity are becoming more prevalent on home networks. For example, botnets of Internet of Things devices engage in denial of service (DoS) attacks and ransomware holds data on personal and commercial systems hostage. Many of these threats are relatively opaque for an end user. An end user may not know that their smart device is participating in a DoS attack at all, unless they notice a protracted slowdown in network speeds. An upstream network provider like a consumer ISP has more visibility into the issue. Due to their privileged position, ISPs often have more data about the status of a malware infection, denial of service attack, or other malicious activity. This extra information can be of great benefit for the purposes of notification. For instance, an ISP may be able to notify a customer that a device on their network is being used for a DoS attackor that they see communication with a server involved in distributing ransomware. ISPs and other organizations that try and implement these schemes often run into a set of questions: How do I get the right data to power the notification? How do I ensure the user trusts the notification? Can I ensure the notification is not spoofed? Is there an optimal way to present the notification? How do I make sure a user takes the proper remedial action? This thesis presents a framework for new notification schemes to answer these questions by examining four key elements of a notification: form, delivery, and content. It also proposes multi-factor verification, a novel scheme to address trust and spoofing issues within a notification scheme. Finally, it provides a model for a new ISP-user security notification scheme within the context of the United States market and policy landscape.
by Nathaniel H. Fruchter.
S.M. in Technology and Policy
S.M.inTechnologyandPolicy Massachusetts Institute of Technology, School of Engineering, Institute for Data, Systems, and Society, Technology and Policy Program
20
Doležal, Martin. "Implementace vybrané technologie pro ISP." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-234777.
Abstract:
The thesis focuses on implementation of selected technology within the company CPU-Kocourek, s.r.o, which provides varied internet services. Based on the theoretical part and the analysis of the current situation are proposed solutions suitable for the management of access network provider. The proposal part contains selection of the best proposal and its implementation into the routine mode of operation.
21
Garshasbi, Farzam, and Ebrahimi Shahram Pasha. "Supply Chain Security Programs Comparing TAPA FSR with ISPS." Thesis, Högskolan i Borås, Institutionen Ingenjörshögskolan, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-16642.
Abstract:
In this era, where international outsourcing and global distribution systems are thriving, providing the security of products in the logistic system is very crucial now. For corporates, it is highly vital to know how secure high-tech products and materials are handled, warehoused and transported as they move throughout the globe. Different international security standards have been introduced, two of which are TAPA FSR and ISPS. TAPA FSR (Freight Security Requirements) defines the smallest required security standards for goods travelling throughout the supply chain and the suitable approaches in keeping those standards. ISPS (International Ship and Port Facility Security) is another security standard which identifies the tasks of governments, shipping companies, shipboard personnel, and port/facility personnel to find security threats and take preemptive actions against security events influencing ships or port facilities used in global business. This research attempts to study the literature on security of transportation in supply chain. By comparing the requirements of TAPA FSR and ISPS, we aim to find their basic differences and to analyze to what extent the two standards respond to the crucial concepts of security in the supply chain.Program: BSc in Industrial Engineering - International Business Engineering
22
Mazaheri, Arsham. "How the ISPS code affects port and port activities." Thesis, Högskolan i Borås, Institutionen Ingenjörshögskolan, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-18834.
Abstract:
Following terrorist attacks on twin towers in the USA and Limburg oil tanker in Yemen, theIMO has defined a supplementary chapter and an appendix named ISPS code to its SOLAS,to prevent similar events in maritime transportation. The ISPS code forces the ports, ships andall organizations, who work in marine industry, to keep their security gates more tightly. Thissituation affects involved parties in good and bad ways. Good impacts like increasing insecurity level, efficiency, effectiveness and competitiveness; and bad effects like increasing inannual costs, administration works and manning.This thesis is based on a study that was run by preparing an electronic questionnaire anddistributing among the Swedish ports to get first hand information about the ISPS codeimpacts on port and port activities. Through them it was found that the ISPS code achieved itsmain goal, which it has been described as less smuggling and less theft in Sweden; whileactually the ISPS is an anti terrorism regulation by its nature.On the other hand, the indirect impacts of the code have played an important role in itssuccess; therefore they have been reviewed as well. The ISPS code’s indirect impacts on portscan be summarized as its effects on efficiency, effectiveness, administration cost, serviceprice, profit, competitiveness, service level, customer satisfaction, damage occurring,documentation, manning , lead time and checking process.Uppsatsnivå: D
23
Cordeiro, Douglas Farias. "Simulação numérica de escoamentos bifásicos com o método ISPH." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-05052014-104029/.
Abstract:
O método ISPH (do inglês, Incompressible Smoothed Particle Hydrodynamics) é um método de aproximação livre de malha que, através de um conjunto finito de partículas e uma formulação completamente Lagrangeana, permite a solução de diversos tipos de escoamentos. Entretanto, sua aplicação para escoamentos bifásicos ainda é um desafio, principalmente no que refere-se à manutenabilidade da interface entre fluidos. Diante disso, nesta tese é apresentado o desenvolvimento de um código numérico baseado no método ISPH, sendo propostas duas técnicas de tratamento de interface. Para tanto é realizado um estudo a cerca do método, considerando diferentes metodologias, e analisando pontos específicos, tais como a solução do campo de pressões. São apresentados resultados que mostram a eficácia do método, tanto em escoamentos monofásicos, quanto em escoamentos multifásicos, onde, neste caso, são destacadas as melhorias obtidas através das técnicas de tratamento de interface propostas. Por fim, é realizado um estudo do comportamento de misturas bifásicas, com referência ao fenômeno da inversão de faseIncompressible Smoothed Particle Hydrodynamics (ISPH) method is a meshless approximation that has been used to simulate several types of fluid flows, through a finite particle set and fully lagrangian formulation. The application of ISPH method in two-fluid flow simulations however, has presented many challenges, specially related to the presence of the interface between different fluids. Thus, we present in this study the development of a numerical code based on ISPH, introducing novel interface treatment techniques. A thorough study about this method is provided, considering different methodologies and analysing specific points such as the position of the interface and the obtained pressure field. Results have been presented to show the methods developed in this thesis efficiently simulate two-fluid flows, illustrating the improvements achieved by the proposed interface treatment techniques. Finally, a study of biphasic mixture behavior is carried out with reference to phase inversion phenomena
24
Cardoso, Luís Filipe Rosa. "Expectativas e carreira dos graduados em MBA pelo ISEG." Master's thesis, Instituto Superior de Economia e Gestão, 2012. http://hdl.handle.net/10400.5/10510.
Abstract:
Mestrado em Gestão de Recursos HumanosFace à actual situação económica do país e às transformações no mundo do trabalho, tem-se verificado um aumento contínuo do desemprego e uma aposta na formação contínua através da frequência e obtenção de graus pós-graduados. A literatura sobre o tema atesta que uma das melhores vias para potenciar a empregabilidade e ganhar maior visibilidade no mercado do trabalho passa por adquirir mais e melhores conhecimentos e competências. Nesse sentido, a obtenção de um título de graduação superior pode permitir aos alunos melhorarem as suas oportunidades de emprego, conceberem uma mudança na carreira profissional e sobretudo alcançarem metas remuneratórias mais elevadas. A presente investigação visa contribuir para o melhor conhecimento desta realidade, focalizando-se sobre as expectativas e carreiras de um sector específico da força-de-trabalho: os alunos graduados em MBA pelo Instituto Superior de Economia e Gestão. O objectivo é analisar se existe adequação ou não das expectativas de carreira ao mercado de trabalho e às relações de trabalho nas organizações onde desempenham a sua actividade. Por intermédio da aplicação de um inquérito, concluiu-se que o que levou os graduados do ISEG a optarem por realizar um MBA foi o facto de poderem aprofundar os seus conhecimentos em torno da Gestão de negócios, melhorar o desempenho profissional e obter melhores perspectivas de carreira, despontando nestes uma melhoria no processo de tomada de decisão, no desenvolvimento do trabalho em equipa, e na aprendizagem de técnicas de negociação.
Due to the current economical situation of the country, and the consequential transformations in the working conditions, Portugal has been facing a continuous increase in the unemployment rate, and the consequent ongoing investment that individuals do on their academic trainings. Everything read about this subject confirms that one of the best ways to improve one's employability and to be known in the work market, is by acquiring more and better knowledge and skills. Therefore, obtaining higher education allows students to improve their job opportunities. It has a positive impact on their professional career and, mainly, allows them to have higher salary expectations. The purpose of this investigation is to better understand this reality, focusing on the expectations and careers of a specific target: ISEG's MBA graduate students. The main goal is to analyze if there is any link between the students' career expectations and their current work situation. By doing a questionnaire, it was possible to conclude that most of the MBA students in ISEG chose to take this degree in order to deepen their knowledge on Business Management. Moreover, students admit that this degree allows them to improve their performance and to gain better career opportunities, by enabling the optimization of the decision-making process, team work, and in learning negotiation techniques.
25
Důbrava, Marek. "Řízení datového toku v ISP síti." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2016. http://www.nusl.cz/ntk/nusl-242049.
Abstract:
The thesis focuses on the control of data flow in networks of Internet service providers. The problem of aggregation and related overload network elements are shown. Theoretical section describes the standardized methods for managing data flow. The parameters associated with managing data flow are described for devices selected devices. The thesis displays measurements depicting to which extent the ECN algorithm occurs in practice. In the thesis is theoretically described HTB program, which is complemented by a newly described algorithm. The new algorithm is implemented into the program and tested on a real network ISP.
26
Pham, Huong Thi Mai. "Attitudes towards inclusive education of students with disabilities in Vietnam : a survey of regular lower secondary school teachers /." Oslo : Department of Special Needs Education, Universitetet i Oslo, 2008. http://www.duo.uio.no/publ/isp/2008/73247/pham_master.pdf.
27
Bertilsson, Emil, and Sebastian Arvidsson. "Fartygsskydd och rollen som SSO : En kvalitativ undersökning om fartygsskyddet och SSOrollenombord på olika typer av fartyg efter införandet avISPS." Thesis, Linnéuniversitetet, Sjöfartshögskolan (SJÖ), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-52406.
Abstract:
Detta examensarbete handlar om fartygsskydd och rollen som SSO på olika fartygstyper. Syftet med undersökningen var att ta reda på vilket sätt fartygstypen och fartområdet fartyget går i påverkar hur man ombord arbetar med fartygsskyddet och ISPS. Denna undersökning genomfördes under sommaren och hösten 2015 genom kvalitativa semistrukturerade intervjuer med SSO:erna på fyra fartyg av olika typ i olika fartområden. Fartygen i undersökningen består av ett kryssningsfartyg i oceanfart, ett tankfartyg i europafart, ett biltransportfartyg i oceanfart samt en färja i närfart. Resultatet av vår undersökning visar att det finns skillnader mellan både de undersökta fartygstyperna och fartområdena samt att detta påverkar hur de intervjuade SSO:erna uppfattar sin roll. Resultatet pekar på att den största skillnaden i organiseringen av fartygsskyddet finns mellan de två huvudtyperna av fartyg i studien, dvs. passagerarfartyg och lastfartyg, och att den skillnaden till stor del kan förklaras av besättningens storlek.This thesis is about ship security and the role of the SSO on different types of vessels. The purpose of the survey was to find out how the ship type and trade area of the ship affects how the on-board work with security and ISPS is conducted. The study was carried out during the summer and autumn 2015 by making qualitative semi-structured interviews with the SSOs on four vessels of different type in different trade areas. The vessels in the survey consist of a cruise ship in ocean traffic, a tanker in European traffic, a car carrier in world-wide ocean traffic and a ferry in short voyage traffic. In the study it was concluded that there are differences between both the investigated vessel types and trade areas, and that this affects how the interviewees: the SSOs perceive their role. The result indicates that the largest difference in the organization of ship security is found between the two main types of vessels in the study, between passenger ships and cargo ships, and that this difference can largely be explained by the size of the crew.
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Pinto, Isabel Cristina Carmo Costa. "Rumo à Universidade empreendedora : o potencial empreendedor dos alunos do ISEG." Master's thesis, Instituto Superior de Economia e Gestão, 2013. http://hdl.handle.net/10400.5/6280.
Abstract:
Mestrado em MarketingA relevância do empreendedorismo e inovação é cada vez mais evidente devido ao papel fundamental que desempenham na sociedade e economia, o que tem tornado esta temática num importante alvo de estudo. A procura pela compreensão do espírito de iniciativa desde a sua origem tem sido crescente, no sentido de perceber qual a melhor forma de estimular cada vez mais e melhores empreendedores. Neste sentido, impõe-se a necessidade de perceber os fatores que levam à intenção de empreender e também de refletir sobre a inserção desta temática desde cedo na vida académica dos indivíduos, como parte complementar da sua aprendizagem. A universidade empreendedora torna-se assim um ponto incontornável nesta temática e um alvo de estudo devido ao papel central que desempenha no empreendedorismo e consequente necessidade de adaptação a tamanha responsabilidade. Perante a frequente dificuldade das universidades de adequar a sua oferta nesta área, no sentido de se tornarem mais empreendedoras, este estudo teve como objetivo principal a compreensão do potencial empreendedor dos alunos de uma Instituição de Ensino Superior específica. Com base na teoria sobre a formação de intenções empreendedoras, foi realizado um estudo de caso que permitiu avaliar o percurso da instituição nesta área, aferir o potencial empreendedor dos respetivos alunos, perceber a relação entre ambos e sugerir medidas para a adaptação da estratégia organizacional de acordo com o potencial de empreendedorismo verificado. O estudo baseou-se numa entrevista semi-estruturada, para perceber a dinâmica interna da instituição, e num inquérito dirigido aos alunos. A partir deste último foi possível perceber o forte potencial empreendedor dos alunos da instituição e a sua relação com o ensino do empreendedorismo. Verificou-se o papel positivo da instituição no fomento do empreendedorismo mas foi possível detetar falhas ao nível da comunicação e oferta de formação nesta área, assim como alguns pontos de melhoria em termos de organização e iniciativas a implementar. A análise do potencial empreendedor dos alunos provou ser um método que permite a adequação da estratégia de ensino às necessidades do seu público, no sentido de vir a proporcionar melhores resultados para ambas as partes: a escola e os seus alunos.
The relevance of entrepreneurship and innovation is increasingly obvious due to the key role they play in Society and Economy, which has made this subject a major focus of study. The search for understanding the entrepreneurial attitude from its origin has been increasing, in the sense of understanding which is the best way to stimulate more and better entrepreneurs. In this regard, it is imperative the need to understand the factors that lead to the entrepreneurial intentions and also to reflect on the inclusion of this issue in an early stage of the academic life of individuals, as a complementary part of their learning. The entrepreneurial university thus becomes an unavoidable point in this matter and a study target, due to the central role it plays on entrepreneurship and consequent need to adapt to such responsibility. Given the frequent difficulty of universities to adapt their offerings in this area, in order to become more entrepreneurial, this research was aimed at understanding the entrepreneurial potential of the students of a specific higher education institution. Based on the theory of formation of entrepreneurial intentions, a case study was carried out to the course of the institution in these matters to measure the entrepreneurial potential of its students, to understand the relationship between both, and finally to suggest measures to adapt the organizational strategy according to its measured entrepreneurial potential. The study was based on a semi-structured interview, to understand the internal dynamics of the institution, and on a survey directed to the students. From this survey it was possible to perceive the strong entrepreneurial potential of the institution’s students and its relation with the entrepreneurship education. The positive role of the institution in promoting entrepreneurship was verified but it was possible to detect some flaws regarding communication and education offering in that area, as well as to suggest some improvement tips regarding management and some initiatives to implement. The assessment of the entrepreneurial potential among students has proven to be a method that allows the adequacy of the teaching strategy to its public’s needs, in order to provide better results in the future for both parties: the school and the students.
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Pliças, Maria Rosa Brás Morais. "Antecedentes das actividades de procura de emprego dos finalistas do ISEG." Master's thesis, Instituto Superior de Economia e Gestão, 2014. http://hdl.handle.net/10400.5/7925.
Abstract:
Mestrado em Gestão de Recursos HumanosNo atual contexto económico e social, assistimos a um crescente aumento do número de pessoas com formação académica superior, não acompanhado pela oferta de emprego do mercado de trabalho. A presente Dissertação pretende estudar as atividades desenvolvidas pelos alunos finalistas das Licenciaturas do ISEG visando a obtenção de emprego no final do curso. O principal objetivo é perceber qual o impacto da inteligência emocional, de características de personalidade (proatividade), de atitudes quanto à procura de emprego (autoeficácia na procura de emprego e indecisão de carreira) e do perfil sociodemográfico (género, idade e licenciatura) no tipo e frequência de realização de atividades de procura de emprego. Todas estas variáveis foram estudadas anteriormente, à exceção da IE, pelo que a inclusão desta variável constitui a originalidade deste estudo. Os resultados indicam que a frequência de realização de atividades genéricas (e.g., candidaturas espontâneas) está positivamente associada à autoeficácia na procura de emprego e que os alunos do género feminino aproveitam mais as atividades proporcionadas pelo ISEG (e.g., participar na Feira de Emprego). Verificou-se ainda uma correlação positiva significativa entre a inteligência emocional e as atividades de iniciativa própria (e.g., estabelecimento de networks com profissionais de referência).
In the current economic and social context, we witness an increasing number of people with University degrees who cannot find a position in the labour market. The current research studies the activities of ISEG's undergraduate students seeking for a job after graduation. Its main goal is to understand the impact of emotional intelligence, personality characteristics (proactivity), attitudes towards job seeking (self-efficacy in job seeking and career indecision) and demographic variables (gender, age and field of studies) on the type and frequency of activities. Undertaken all these variables were studied before, with the exception of EI. Therefore, the inclusion of EI is the main originality of this study. Results indicate that the frequency of general activities (e.g., spontaneous applications) is positively associated with self-efficacy and that female students take more advantage of activities offered by ISEG (e.g., job fairs). A significant positive correlation was found between emotional intelligence and self-initiative activities non traditional (e.g., establishing network, with reference professionals).
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Price, Patrick D. "Toward an internet service provider (ISP) centric security." Thesis, Monterey, California. Naval Postgraduate School, 2003. http://hdl.handle.net/10945/6033.
Abstract:
Approved for public release; distribution is unlimitedThis thesis was completed in cooperation with the Institute for Information Superiority and Innovation.
Individual users, businesses, and governments have become functionally dependent on the Internet's connectivity to interact at the most basic levels of social and economic intercourse. Yet self-propagating worms and distributed denial of service attacks have demonstrated that disruption of the Internet infrastructure can be quickly achieved despite the vast knowledge of vulnerabilities and readily available subscriber-based countermeasures. In part, this condition is made possible because networks continue to operate under an obsolete subscriber-centric security paradigm that is based on all end users being trusted to act appropriately. This thesis develops the idea of an Internet Service Provider (ISP)- centric security approach by examining the types, roles, security mechanisms, and operational precepts of ISP's to illustrate their functional control within the infrastructure. Denial of service and worm attacks are detailed to provide the context for an emerging set of conditions that forms the basis of the requirement for the ISP approach. This paper concludes by examining four enabling technologies currently available that, used uniformly, provide ISPs with the framework to implement Internet based security that can serve to enhance the layered defense model and invoke the tenants of best practices.
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Hurtado, del Nido Andrés Felipe. "Evaluación Económica para Servicios ISP de Carácter Regional." Tesis, Universidad de Chile, 2010. http://www.repositorio.uchile.cl/handle/2250/103831.
Abstract:
Al analizar el comportamiento de un usuario promedio de Internet en Chile, se observa el uso de diversos servicios tales como visualización de páginas Web, correo, videos en línea, juegos, etc. Sin embargo, estos contenidos se encuentran alojados principalmente en servidores de EEUU y Europa. Esta distribución de la información tiene un costo a considerar, por cuanto cada byte transmitido entre quien hospeda los contenidos y el usuario final debe hacer uso de una extensa red, la cual posibilite la conexión entre estos actores. Así, al considerar el sostenido crecimiento en la penetración nacional de Internet, junto con las constantes alzas de las tasas de transferencia en los servicios ofrecidos, el pago por el uso de las redes internacionales se vuelve cada vez más gravitante, convirtiéndose en una componente influyente en la estructura de costos de los ISP’s y, en definitiva, de los usuarios. Sin embargo, este no es sólo un problema económico, pues a mayor lejanía entre los contenidos y su suscriptor, este verá más deteriorada la calidad del servicio entregado.
Al buscar una solución a esta problemática, es posible generar un conjunto de alternativas, todas ellas enmarcadas en “Redes de contenidos distribuidos”, las que, entre otros beneficios, generan una optimización en el uso de los enlaces internacionales. El modelo planteado, propone el traslado de contenidos desde los hosts originales que prestan los servicios, a otros nacionales o regionales. Se genera así, una primera mirada a los aspectos técnicos y económicos involucrados en dicha propuesta, basados en una “fotografía” realizada al mercado chileno, su evolución en los pasados años y su proyección en un mediano plazo.
Luego, se analizan de modo general, tanto las componentes técnicas como económicas involucradas, donde se esclarece si un proyecto bajo estas características generará ahorros reales para los ISP nacionales y, en consecuencia, para los usuarios. Un resultado importante muestra que la implementación de este tipo de redes, se justifica no sólo por los ahorros generados, sino también por la limitada capacidad de los enlaces internacionales existentes. Se genera así, no sólo un uso más eficiente del ancho de banda internacional, sino que también una mejor experiencia para los usuarios, disminuyendo los tiempos de despliegue de las páginas y servicios Web, así como en los servicios de descarga de archivos.
La implementación de un proyecto de estas características, requerirá el esfuerzo de un conglomerado de compañías junto a entes gubernamentales, con tal de establecer confianzas en los generadores de contenidos, lo cual permita el traslado de los contenidos y servicios a servidores regionales. Un trabajo futuro debe considerar las condiciones necesarias a desarrollar para la instalación de la solución, así como un estudio acabado sobre el tráfico cursado por los internautas nacionales en diversos niveles.
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Kmoníček, Tomáš. "Aplikace pro monitorování a správu sítě pro ISP." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2009. http://www.nusl.cz/ntk/nusl-217877.
Abstract:
The objective of this master‘s thesis is to develop an ISP application for service monitoring and management. A fully functioning monitoring software has been developed that allows the administrator to check round-trip time and packet loss in the entire network. Another function of the application is obtaining information from network devices by the SNMP protocol (e.g. packet and byte count etc.). The software uses this information to create graphs per hour, day, week or year. All graphs and statistics are visualised on the administration website. For the purpose of client administration, a client database has been developed. This part of the application enables the management of payments, IP addresses, contacts etc. Both parts of the web pages have been developed by using mod_python and AJAX, making the application similar to standard desktop applications. The testing application has been developed by using Python and the entire application has been designed for modules, which can be later used for the development of other functions.
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Vašák, Michal. "Preparation of a hands-on tutorial teaching basics of Mainframe ISPF programming." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-82046.
Abstract:
This paper is primarily focused on developers wanting to learn the essentials of developing mainframe applications on the IBM`s Interactive System Productivity Facility (ISPF) platform. It describes the components of the ISPF environment, focusing mainly on the two components most used in mainframe application development: The ISPF Dialog Manager and the ISPF Program Development Facility (PDF). Second part of the paper is a hands-on tutorial, where the reader is guided trough the creation of a set of simple interactive ISPF applications, with focus on covering the most used features of the platform. Within the paper it is assumed that any reader interested in this topic has basic mainframe skills and knowledge, including user knowledge of ISPF PDF, as it is usually the primary tool for dataset manipulation and editing in the z/OS mainframe environment. A wider skill set is assumed for readers who want to go through the tutorial, for example REXX and z/OS assembler basics. However none of these skills are necessary, nor expected, from those who are mainly interested in finding out what ISPF is and what it can offer to z/OS applications and their developers.
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Lauer, Mark J. "Validating the ISPI standards and principles for the Certified Performance Technologist credential." [Bloomington, Ind.] : Indiana University, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3331327.
Abstract:
Thesis (Ph.D.)--Indiana University, Dept. of Instructional Systems Technology, 2008.Title from PDF t.p. (viewed on Jul 24, 2009). Source: Dissertation Abstracts International, Volume: 69-11, Section: A, page: 4407. Adviser: James Pershing.
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Karagkounis, Anastasios. "Locality Awareness and ISP-Friendlinessfor P2P Live Streaming Applications." Thesis, KTH, Kommunikationsnät, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-103100.
Abstract:
The popularity of P2P live streaming applications has been growing rapidly the last years causing a remarkable increase in consumption of critical network resources. The peers that participate in the P2P overlays inherently establish random connections with each other without considering the locality of the generated traffic. As a result, higher costs and risks are shifted to the ISP side and cross-ISP links are used to connect remote peers. The network infrastructure will face problems in satisfying the aforementioned need and eventually both ISPs and P2P systems might suffer from this situation. In order to enhance the P2P overlays with locality-awareness and reduce this unnecessary cost for the ISPs, several schemes have been proposed. However, in the case of P2P live streaming applications, the randomness in overlay links seems more significant for the expected QoE than it is for the performance in other P2P systems. In this thesis, we describe an ISPF patch based on a decentralized, latency-biased, neighbor referral selection technique that is targeted for use in large commercial P2P live streaming systems. More specifically, we create an extra component that can work on the background of any existing P2P live streaming application. The component is able to promote a list of local peers as partner-candidate peers according to their latencies -measured by the peers themselves or referred to them by their known neighbors. The implementation of the ISPF component is coded and applied on an existing implementation of a Coolstreaming+ system and simulations of the two systems are executed on an eventbased simulator. The evaluation focuses on the comparison of performance and locality metrics between ISPFCoolstreaming and the native Coolstreaming+ simulation results. The comparison shows that the expected performance degradation is small and varies according to the churn levels and overlay sizes. More importantly, it is made clear that the achievements in locality-awareness are significant in all scenarios. We conclude that the ISPF component could be efficiently used in an optional mode by a P2P live streaming algorithm. It could be enabled during big size overlays where the impact in performance is absorbed better and the savings in resources are bigger.
36
Gao, Hongyan. "Network and I/O Characteristics of ISP Mail Servers." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1013197957.
37
Král, Tomáš. "Posouzení efektivnosti informačního systému pro ISP a návrh změny." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2012. http://www.nusl.cz/ntk/nusl-223521.
Abstract:
This master’s thesis focuses on description and evaluation of effectiveness of the current information system by means of selected methods and following proposal of changes which should lead in enhancement of the overall ICT condition in the analysed company. This company works in the field of information/telecommunication services.
38
Baumgartner, Corinne. "Strukturbasiertes Design und Synthese von Inhibitoren des Enzyms IspF als potentielle Antimalaria-Wirkstoffe /." Zürich : ETH, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17402.
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Mendonça, Ana Raquel Gonçalves. "Estudo da viabilidade económico-financeira de uma residência de estudantes para o ISEG." Master's thesis, Instituto Superior de Economia e Gestão, 2012. http://hdl.handle.net/10400.5/4951.
Abstract:
Mestrado em FinançasFoi há mais de 60 anos que foi inaugurada a primeira residência universitária em Portugal, e com o passar dos anos foram várias as residências construídas em todo o país para dar alojamento aos estudantes do ensino superior. Actualmente, a procura de alojamento nestas residências tem vindo ao aumentar, muito por culpa da situação económica, mas também da mobilidade nacional e internacional dos estudantes, docentes e investigadores do ensino superior. Com este aumento dos pedidos de alojamento, a Universidade Técnica de Lisboa (UTL), a qual pertence o Instituto Superior de Economia e Gestão (ISEG), não consegue dar resposta a todos os pedidos, e nesse sentido, o objectivo deste trabalho é estudar a viabilidade económico-financeira de uma residência de estudantes para o ISEG. Com este objectivo, procedeu-se à análise de mercado de todas as residências universitárias do concelho de Lisboa, à procura da melhor localização para a construção da residência e à caracterização de todos os espaços e funcionamento da mesma. Elaborou-se ainda todos os mapas necessários à avaliação económica e financeira do projecto. Por fim, conclui-se que, com base nos pressupostos definidos, a residência não é economicamente viável. É de reforçar que, apesar de todos os esforços, não foi possível considerar qualquer financiamento do Estado, o que podia alterar as decisões de viabilidade do projecto.
The first student dormitory built in Portugal was inaugurated more than sixty years ago, and over the past years there were several other dormitories built around the country, to give accommodation to students in higher education. Nowadays the demand for accommodation in these dorms is increasing very much, not only because of the economic crises, but also because of the national and international mobility of students, teachers and researchers in higher education. The Instituto Superior de Economia e Gestão (ISEG) which belongs to the Universidade Técnica de Lisboa (UTL) has become unable to respond to all requests. So, the aim of this project is studying the economic and financial viability of student dormitory for the ISEG. With this objective, I developed a market analysis of all dormitories in the city of Lisbon, looked for the best location for a new dormitory, and carried out a complete characterization of all the spaces and functions required. I also prepared all the maps necessary for the economic and financial evolution of the project. Finally, it was concluded that, on the basis of the assumptions set, the dormitory is not economically viable. It should be noted that, despite all efforts, it was not possible to consider any state funding. Would it have been taken into consideration the project could have been viable.
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Duarte, Ana Isabel Fonseca. "Afetação de salas para realização de provas de avaliação : uma aplicação no ISEG." Master's thesis, Instituto Superior de Economia e Gestão, 2018. http://hdl.handle.net/10400.5/17059.
Abstract:
Mestrado em Métodos Quantitativos para a Decisão Económica e EmpresarialO presente trabalho de projeto visa a criação de uma plataforma que permita à Secretaria das Licenciaturas do ISEG a afetação automática de salas para a realização de provas de avaliação de unidades curriculares (UC). Atualmente, este processo é efetuado de forma manual por funcionários desta secretaria, o que, face às dimensões das instâncias, o torna bastante moroso. A plataforma tem como objetivo a minimização da distância entre salas afetas sucessivamente à mesma prova de avaliação, bem como do número de lugares vazios na primeira sala afeta a cada prova, excluindo os casos de salas grandes e de provas de avaliação com muitos alunos inscritos. Adicionalmente, desenvolve-se um modelo de programação linear inteira (PLI), cujo objetivo é minimizar o número total de salas afetas, bem como a distância entre salas afetas à mesma prova. Em ambos os casos, é necessário ter em conta a capacidade e disponibilidade de cada sala, bem como a imposição de não afetar a mesma sala a mais do que uma prova, no mesmo período do mesmo dia de uma época de avaliação. As metodologias foram testadas e comparadas considerando diferentes cenários, nos quais se varia o número e capacidade das salas disponíveis, bem como o número de alunos inscritos por prova. Desta forma, concluiu-se que em ambos os métodos o número total de salas afetas é bastante semelhante, contrariamente ao que acontece com a distância total entre salas afetas, pois o valor obtido é bastante menor quando aplicado o modelo de PLI.
The aim of this work is to create a platform that allows the Undergraduate Office of ISEG to automatically assign rooms to evaluation tests. Currently, this process is carried out manually by employees of this office what, due to the dimensions of the instances, is quite time consuming. The purpose of this platform is to minimize the distance between rooms consecutively assigned to the same evaluation test, as well as the number of empty seats in the first room allocated to each test, excluding the cases of large rooms and of evaluation tests with many enrolled students. Additionally, an integer linear programming model (ILP) is developed with the objective of minimizing the total number of assigned rooms, as well as the distance between rooms allocated to the same test. In both cases the capacity and availability of each room must be taken into account, as well as the fact that each room cannot be assigned more than once, in the same period of the same day of an evaluation period. The methodologies were tested and compared considering different scenarios, in which the number and capacity of the available rooms varies, as well as the number of students enrolled per test. As a conclusion, it is observed that the total number of assigned rooms is quite similar in both methods, contrary to what happens with the total distance between allocated rooms, since the result obtained is much lower when the ILP model is applied.
info:eu-repo/semantics/publishedVersion
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Oliveira, Nídia Ramos. "Os dilemas éticos dos profissionais de gestão de recursos humanos formados pelo ISEG." Master's thesis, Instituto Superior de Economia e Gestão, 2018. http://hdl.handle.net/10400.5/16645.
Abstract:
Mestrado em Gestão de Recursos HumanosO presente trabalho tem por objetivo estudar os dilemas éticos existentes, em contexto profissional, dos estudantes de GRH formados pelo ISEG. A amostra é constituída por vinte profissionais que frequentaram a unidade curricular de Ética Empresarial. O levantamento dos dilemas existentes e o investimento que as empresas onde trabalham fazem para proporcionar um clima ético dentro das suas organizações, foram duas das componentes analisadas. Com esta investigação constatou-se que são profissionais preparados para lidar com questões éticas nas organizações, embora demonstrem algumas fragilidades no que diz respeito a decisões que envolvem o distanciamento das suas emoções e relações afetivas.
The presented report has as it's main purpose to study the existing ethical dilemmas, in a professional context, of the students of HRM, educated by the ISEG. The sample is based on 20 professional individuals that attended the curricular unit of Business Ethics. The research upon the existing dilemmas and the investment that the companies - where they work - make to maintain an ethical environment within their organizations, are two of the analyzed components. With this investigation, it can be stated that they are professionally qualified individuals, ready to deal with ethical issues within their organizations, although they also demonstrate some weaknesses in the emotional distancing area and their sentimental relationships.
info:eu-repo/semantics/publishedVersion
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HASSANI, SEYED RASHIDALDIN. "QoS management in DSL services of an ISP in Iran." Thesis, Halmstad University, School of Information Science, Computer and Electrical Engineering (IDE), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-5613.
Abstract:
Quality of Service is a set of mechanisms created for differentiating users and data flows. Provisioning the QoS in service provider networks is always interesting for their business departments for they can offer and sell diverse services and to make more money. This thesis QoS for DSL subscribers of Pardis Online - the private ISP in Iran. The size of the network, the certain network connectivity limitations the ISP has in addition to the complexity of the services it provides, necessitate a comprehensive study to elucidate the different service types and requirements and then choosing a specific implementation of QoS in order to meet the ISP’s need. The internet bandwidth in the region that ISP operates is very expensive and the users suffer from the lack of bandwidth so the limited internet links are usually congested in the network. This document concludes with proposing a layered QoS that guarantees that the total bandwidth of an area in congested times is distributed to the users in that area proportionate to the subscribed band width. The resulting proposals are tested in the Lab and their performance under the simulated traffic is monitored and analyzed.
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Francois, Frederic. "Policy-driven traffic engineering in energy-aware ISP backbone networks." Thesis, University of Surrey, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606700.
Abstract:
The excessive energy consumption of backbone networks is causing concerns among network operators. This thesis focuses on the design of Energy-aware Traffic Engineering (ETE) schemes which improve the energy-efficiency of different backbone networks by enabling the delivery of traffic by the smallest number of network devices so that the remaining devices can go to sleep during the periods of low traffic demands. The first proposed ETE scheme is called Time-driven Link Sleeping (TLS) which uses only two network routing topologies: the full topology with all links being active, and a reduced one with a subset of links sleeping. The key novelty of TLS lies in its ability to jointly optimize the reduced network topology and the off-peak period during which it is operated. Moreover, an extension to TLS makes it robust to single link failures. The second ETE scheme is a Green Load-balancing Algorithm (GLA) which complements TLS and other existing ETE schemes by jointly optimizing the IGP link weights in backbone networks for improved load-balancing and energy-efficiency after these existing ETE schemes put links to sleep. The final contribution is an online distributed ETE scheme called Green. Backup Paths (GBP) which dynamically diverts traffic from some selected links onto their backup paths, which were pre-installed to protect against link failure, so that these links have the opportunity to go to sleep without affecting the primary purpose of the backup paths. The distributed nature of GBP makes it scalable to large networks and be very responsive to sudden traffic changes since multiple routers can concurrently make interference-free decisions. The simple TLS scheme with GLA is ideally suited for networks which experience a regular traffic pattern because of their , offline nature while the more 'complex GBP scheme is more suitable when there is dynamic traffic because of its online nature.
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Krute, Christina Nadia. "Investigation of Post-Translational Modifications in Staphylococcus aureus." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5719.
Abstract:
The work presented herein details post-translational modifications (PTMs) in Staphylococcus aureus that are involved in mediating the stress response and normal cellular processes. The first PTM that was investigated is regulated intramembrane proteolysis (RIP) for the activation of the ECF sigma factor σS. We achieved this by analyzing the role of the site-1 protease, which we termed “putative regulator of sigmaS” (PrsS), as it is predicted to be the first enzyme in the RIP cascade, leading to the activation of σS. It was determined that the putative site-1 protease, prsS, mimics transcriptional profiles of sigS; with expression low in all strains examined other than in the highly mutagenic strain RN4220. Moreover, up-regulation of the protease was observed in response to cell wall-targeting antibiotics, DNA-damaging agents, and during infection in human serum and RAW 264.7 cells, similar to that previously demonstrated for sigS. It was further determined that prsS mutants, like sigS mutants, are more sensitive to cell wall-targeting antibiotics and DNA-damaging agents, which is explained, in part, by alterations in altered abundance of proteins in the prsS mutant that mediate antibiotic resistance (Pbp2a, FemB, and HmrA) and the response to DNA damage (BmrA, Hpt, and Tag). Importantly, transcriptional analyses of proteins affected in the protease mutant, revealed that their expression is decreased in both prsS and sigS mutants, suggesting that this is a result of sigS-mediated regulation. Lastly, it was determined that PrsS, similar to σS, is required for infection in whole human blood and murine models of virulence. Next, since the abundance of a stress response protease, HtrA1, was altered in prsS mutants, we aimed to assess the roles of this enzyme, and its homolog HtrA2 in S. aureus. Interestingly, we first determined that unlike that previously described for the HtrA enzymes, these proteases do not have a role in Agr-mediated virulence regulation. We attribute this finding to unintended mutations likely introduced during strain construction, which is common for S. aureus strains. We next used transcription profiling of the htrA genes in order to understand their role in the cell, and found that they are moderately expressed under standard conditions, and are up-regulated in response to both in vitro and ex vivo stressors that lead to cell protein, DNA, and cell envelope damage. Further to this, the protease mutants are more sensitive to numerous conditions that affect macromolecular stability, including elevated temperature, alterations in pH, reactive oxygen species, DNA damage, and antimicrobial stress. In order to further explore these sensitivities and gain insight into putative substrates, we employed a yeast-2 hybrid screen, and identified numerous proteins that interact with HtrA1 and HtrA2, including those that mediate the response to stress and normal cellular homeostasis. Taken together, we provide evidence to suggest the HtrA proteases in S. aureus are required both during standard conditions and in stress-inducing environments to mediate protein folding and proteolysis of a broad range of substrates. Finally, we performed the first examination of prenylation in a bacterial organism. Prenylation is a well-studied post-translational modification (PTM) in eukaryotes, wherein a prenyl group is added to a metabolite or the C-terminal “CAAX” motif of a protein. Interestingly, the machinery exists for this PTM in a wide variety of prokaryotic species, thus we set out to investigate its impact in S. aureus. To achieve this, we disrupted prenyl group synthesis by inactivating ispA, the gene encoding a prenyl synthetase. The abrogation of prenylation ensued in striking alterations in the cell, including lack of pigmentation and smaller colony size, similar to small-colony variants (SCVs) of S. aureus. In addition to this, the ispA mutant displayed a growth defect, as a result of lower ATP levels. Moreover, the prenylation mutant displayed alterations in resistance to antibiotics, including increased resistance to aminoglycosides and antimicrobial peptides (AMPs), yet elevated sensitivity to cell wall-targeting antibiotics. These differences in susceptibility to cell envelope targeting antibiotics are a result of alterations in cell envelope architecture, including variations in fatty acid composition and increased membrane fluidity. Collectively, the pleotropic consequences of the disruption of prenylation indicate that this process is key to maintaining cellular homeostasis in S. aureus, and perhaps other bacterial species.
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Bondan, Widyatmoko. "The Implementation of Indonesian Sustainable Palm Oil Certification (ISPO):Opportunity for Inclusion of Palm Oil Smallholder in Riau Province." Kyoto University, 2019. http://hdl.handle.net/2433/242760.
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Gräwert, Tobias Wilhelm. "IspH-Protein aus Escherichia coli und IspDF-Protein aus Campylobacter jejuni Untersuchung und Charakterisierung /." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980365236.
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Campbell, Tracey L. BROWN E. D. "Investigating the uncharacterized proteins IspF and YjeQ and their roles in essential bacterial physiology." *McMaster only, 2007.
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Sandford, Peter. "Inferring malicious network events in commercial ISP networks using traffic summarisation." Thesis, Loughborough University, 2012. https://dspace.lboro.ac.uk/2134/9580.
Abstract:
With the recent increases in bandwidth available to home users, traffic rates for commercial national networks have also been increasing rapidly. This presents a problem for any network monitoring tool as the traffic rate they are expected to monitor is rising on a monthly basis. Security within these networks is para- mount as they are now an accepted home of trade and commerce. Core networks have been demonstrably and repeatedly open to attack; these events have had significant material costs to high profile targets. Network monitoring is an important part of network security, providing in- formation about potential security breaches and in understanding their impact. Monitoring at high data rates is a significant problem; both in terms of processing the information at line rates, and in terms of presenting the relevant information to the appropriate persons or systems. This thesis suggests that the use of summary statistics, gathered over a num- ber of packets, is a sensible and effective way of coping with high data rates. A methodology for discovering which metrics are appropriate for classifying signi- ficant network events using statistical summaries is presented. It is shown that the statistical measures found with this methodology can be used effectively as a metric for defining periods of significant anomaly, and further classifying these anomalies as legitimate or otherwise. In a laboratory environment, these metrics were used to detect DoS traffic representing as little as 0.1% of the overall network traffic. The metrics discovered were then analysed to demonstrate that they are ap- propriate and rational metrics for the detection of network level anomalies. These metrics were shown to have distinctive characteristics during DoS by the analysis of live network observations taken during DoS events. This work was implemented and operated within a live system, at multiple sites within the core of a commercial ISP network. The statistical summaries are generated at city based points of presence and gathered centrally to allow for spacial and topological correlation of security events. The architecture chosen was shown to be exible in its application. The system was used to detect the level of VoIP traffic present on the network through the implementation of packet size distribution analysis in a multi-gigabit environment. It was also used to detect unsolicited SMTP generators injecting messages into the core. ii Monitoring in a commercial network environment is subject to data protec- tion legislation. Accordingly the system presented processed only network and transport layer headers, all other data being discarded at the capture interface. The system described in this thesis was operational for a period of 6 months, during which a set of over 140 network anomalies, both malicious and benign were observed over a range of localities. The system design, example anomalies and metric analysis form the majority of this thesis.
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Feng, Junjie. "ISG expression screening reveals the family-specific antibunyaviral activity of ISG20." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8610/.
Abstract:
Order Bunyavirales poses a significant threat to the agricultural industry, animal husbandry and human welfare. In response to viral infections, interferons (IFNs) trigger the expression of numerous interferon stimulated genes (ISGs) whose concerted action can potently inhibit the replication of bunyaviruses. We used a FACS-based method to screen the ability of ~500 unique ISGs from humans or rhesus macaques to inhibit the replication of Bunyamwera virus (BUNV), the prototype of both the Peribunyaviridae family and Bunyavirales order. Candidates possessing antibunyaviral activity were further examined using a panel of divergent bunyaviruses in family Peribunyaviridae, Hantaviridae, Nairoviridae and Phenuiviridae.
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Span, Ingrid [Verfasser]. "Strukturelle und funktionelle Charakterisierung des Eisen-Schwefel-Proteins IspH in Komplex mit Liganden / Ingrid Span." München : Verlag Dr. Hut, 2012. http://d-nb.info/1028783434/34.