Academic literature on the topic 'ISOPETASINA'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'ISOPETASINA.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "ISOPETASINA"
Witschel, Matthias Christian, and Hans Jürgen Bestmann. "Synthese der Pestwurzinhaltsstoffe (+)-Petasin und (+)-Isopetasin." Tetrahedron Letters 36, no. 19 (May 1995): 3325–28. http://dx.doi.org/10.1016/0040-4039(95)00475-r.
Full textWitschel, Matthias C., and Hans Jürgen Bestmann. "The Total Synthesis of (+)-Petasin and (+)-Isopetasin." Synthesis 1997, no. 01 (January 1997): 107–12. http://dx.doi.org/10.1055/s-1997-1492.
Full textWITSCHEL, M. C., and H. J. BESTMANN. "ChemInform Abstract: The Total Synthesis of (+)-Petasin and (+)-Isopetasin." ChemInform 28, no. 23 (August 3, 2010): no. http://dx.doi.org/10.1002/chin.199723211.
Full textUrda, Lorena, Matthias Heinrich Kreuter, Jürgen Drewe, Georg Boonen, Veronika Butterweck, and Thomas Klimkait. "The Petasites hybridus CO2 Extract (Ze 339) Blocks SARS-CoV-2 Replication In Vitro." Viruses 14, no. 1 (January 7, 2022): 106. http://dx.doi.org/10.3390/v14010106.
Full textWITSCHEL, M. C., and H. J. BESTMANN. "ChemInform Abstract: Synthesis of (+)-Petasin and (+)-Isopetasin, Constituents of Petasitis hybridus." ChemInform 26, no. 35 (August 17, 2010): no. http://dx.doi.org/10.1002/chin.199535301.
Full textThomet, O. A. R., U. N. Wiesmann, K. Blaser, and H. U. Simon. "Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils." Clinical & Experimental Allergy 31, no. 8 (August 2001): 1310–20. http://dx.doi.org/10.1046/j.1365-2222.2001.01158.x.
Full textLin, Ling-Hung, Tzu-Jung Huang, Sheng-Hao Wang, Yun-Lian Lin, Sheng-Nan Wu, and Wun-Chang Ko. "Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness." European Journal of Pharmacology 584, no. 2-3 (April 2008): 398–404. http://dx.doi.org/10.1016/j.ejphar.2008.02.034.
Full textKo, Wun-Chang, Sheng-Hao Wang, Mei-Chun Chen, Yun-Lian Lin, and Chieh-Fu Chen. "S-Isopetasin, A Sesquiterpene of Petasites formosanus, Allosterically Antagonized Carbachol in Isolated Guinea Pig Atria." Planta Medica 68, no. 7 (July 2002): 652–55. http://dx.doi.org/10.1055/s-2002-32905.
Full textBenemei, Silvia, Francesco De Logu, Simone Li Puma, Ilaria Maddalena Marone, Elisabetta Coppi, Filippo Ugolini, Wolfgang Liedtke, et al. "The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel." British Journal of Pharmacology 174, no. 17 (July 20, 2017): 2897–911. http://dx.doi.org/10.1111/bph.13917.
Full textDisch, Lucia, Kristina Forsch, Beate Siewert, Jürgen Drewe, and Gert Fricker. "In Vitro and In Situ Absorption and Metabolism of Sesquiterpenes from Petasites hybridus Extracts." Planta Medica 84, no. 11 (January 16, 2018): 795–805. http://dx.doi.org/10.1055/s-0044-100401.
Full textDissertations / Theses on the topic "ISOPETASINA"
Puma, Simone Li. "Ruolo dei canali Transient Receptor Potential (TRP) espressi in cellule neuronali e non neuronali, nelle patologie dolorose di origine infiammatoria e neuropatica." Doctoral thesis, 2020. http://hdl.handle.net/2158/1206841.
Full textHuang, Tzu-Jung, and 黃子容. "Mechanisms of antiasthmatic action of S-petasin and S-isopetasin, sesquiterpenes of petasites formosanus." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/31364321995586500372.
Full text臺北醫學大學
藥理學研究所
95
PDE4 is present in inflammatory cells and bronchial smooth muscles. The increased cAMP level by PDE4 inhibitors leads to have bronchodilator and anti-inflammatory effects. Petasites formosanus Kitamura, a perennial herb, is used as a folk medicine for treating hypertension, tumor and asthma in Taiwan. In the present study, we investigated mechanisms of antiasthmatic action of S-petasin and S-isopetasin, the main constituents of the plant. First, S-petasin has proven to concentration-dependently inhibit PDE3/4 activities with a respective IC50 value of 27.55 and 16.56 μM, which did not significantly differ from each other. According to the Lineweaver-Burk analysis, S-petasin (3~30 μM) competitively inhibited PDE3/4 activities, and had a Ki value of 27.6 and 23.3 μM, respectively, which also did not differ from each other. However, S-isopetasin had no effect on PDE1~PDE5 (IC50 > 100 μM). The airway hyperresponsiveness (AHR) was measured in unrestrained, sensitized and OVA-secondarily challenged BALB/c mice by barometric plethysmography using a whole-body plethysmograph after exposure of methacholine (MCh, 6.25~50 mg/ml). In the present results, S-petasin (10~30 μmol/kg, s.c. or 30~100 μmol/kg, p.o.) dose-dependently and significantly attenuated the enhanced pause (Penh) value induced by MCh (50 mg/ml) and significantly suppressed the increase of total inflammatory cells, eosinophils, neutrophils, and lymphocytes, and also significantly attenuated the release of IL-2, IL-4, IL-5, IFN-γ and TNF-α in bronchoalveolar lavage fluid (BALF) of the mice with some exceptions at lower dose. It also significantly reduced total and OVA-specific IgE in serum and in BALF. In the opposite, it dose-dependently and significantly increased IgG2a in serum suggesting that the anti-inflammation was potentiated. S-petasin displaced [3H]-rolipram from high affinity rolipram binding sites (HARBS) of particulates of whole brains isolated from sensitized guinea pigs, with an EC50 value beyond 300 μM. Therefore, the PDE4H/PDE4L ratio (> 300 μM/16.56 μM) of S-petasin was beyond 18. S-petasin did not shorten the duration of anathesia induced by xylazine/ketamine, suggesting that its adverse effect, such as nausea, vomiting and gastric hypersecretion, may be little. S-petasin (30~300 μM) and S-isopetasin (30~300 μM) significantly relaxed the baseline tension, but did not suppress cumulative OVA (10~100 μg/ml)-induced contractions in isolated sensitized guinea pig trachealis. S-isopetasin (30~300 μM) competitively antagonized cumulative ACh-induced contractions in guinea pig trachealis, because the slope of Schild plot did not significantly differ from unity. The pA2 value of S-isopetasin was calculated to be 4.70 ± 0.66 (n=18). According to the analysis of Scatchard plot, the muscarinic receptor binding sites in cultured human tracheal smooth muscle cells (HTSMCs) revealed a single population (Hill coefficient 1.00). The equilibrium dissociation constant (Kd) and the maximal receptor density (Bmax) for [3H]-NMS binding were 766 pM and 0.189 pmol/mg of protein, respectively. The –logIC50 value of S-isopetasin, methoctramine and 4-DAMP for displacing 0.4 nM [3H]-NMS specific binding was 5.05, 6.25, and 8.56, respectively, suggesting that the [3H]-NMS binding is predominantly on M3 cholinoceptors of cultured HTSMCs. The potency of S-petasin for displacing [3H]-NMS binding in cultured HTSMCs appeared greater (about 2.2-fold) than that against cumulative ACh-induced contractions in guinea pig trachealis, suggesting that S-isopetasin may be more effective in human airway smooth muscles than in guinea pig trachealis. Threfore, S-isopetasin may have benefits as a bronchodilator for treating asthma. In conclusion, S-petasin selectively and competitively inhibited PDE3/4 activities, and potentiated its anti-inflammatory and bronchodilator effects. S-isopetasin antagonized the activation of M3 cholinoceptors of cultured HTSMCs and had bronchodilator effect. The above results suggest that S-petasin and S-isopetasin may have the potential for treating asthma.
Book chapters on the topic "ISOPETASINA"
"3α-Angeloyloxy-eremophila-9(10),7(11)-dien-8-one (Iso-Petasin; Isopetasin)." In Natural Compounds, 502–3. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-0539-9_1009.
Full text"3α-[(Z)-3-Methylthioacryloyloxy]-eremophila-9(10),7(11)-dien-8-one (Iso-S-Petasin; S-Isopetasin)." In Natural Compounds, 530. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-0539-9_1061.
Full text