Relevant bibliographies by topics / Isopenicillin N

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Isopenicillin N'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Isopenicillin N.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Isopenicillin N"

1

Baldwin, Jack E., and Mark Bradley. "Isopenicillin N synthase: mechanistic studies." Chemical Reviews 90, no. 7 (November 1990): 1079–88. http://dx.doi.org/10.1021/cr00105a001.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Chapman, Nicole C., and Peter J. Rutledge. "Isopenicillin N Synthase: Crystallographic Studies." ChemBioChem 22, no. 10 (March 25, 2021): 1687–705. http://dx.doi.org/10.1002/cbic.202000743.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Lau, Rute Madeira, Jacques T. H. van Eupen, Dick Schipper, Godefridus I. Tesser, Jan Verweij, and Erik de Vroom. "Synthesis of Penicillin N and Isopenicillin N." Tetrahedron 56, no. 38 (September 2000): 7601–6. http://dx.doi.org/10.1016/s0040-4020(00)00673-6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Chen, V. J., A. M. Orville, M. R. Harpel, C. A. Frolik, K. K. Surerus, E. Münck, and J. D. Lipscomb. "Spectroscopic Studies of Isopenicillin N Synthase." Journal of Biological Chemistry 264, no. 36 (December 1989): 21677–81. http://dx.doi.org/10.1016/s0021-9258(20)88239-8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Baldwin, Jack E., Mark Bradley, Shaun D. Abbott, and Robert M. Adlington. "New penicillins from isopenicillin N synthase." Tetrahedron 47, no. 28 (January 1991): 5309–28. http://dx.doi.org/10.1016/s0040-4020(01)87142-8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Huffman, George W., Paul D. Gesellchen, Jan R. Turner, Robert B. Rothenberger, Harold E. Osborne, F. Dean Miller, Jerry L. Chapman, and Stephen W. Queener. "Substrate specificity of isopenicillin N synthase." Journal of Medicinal Chemistry 35, no. 10 (May 1992): 1897–914. http://dx.doi.org/10.1021/jm00088a028.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Sim, T. S., and P. Loke. "Molecular studies on isopenicillin N synthases." Applied Microbiology and Biotechnology 54, no. 1 (July 14, 2000): 1–8. http://dx.doi.org/10.1007/s002530000347.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Huffman, George W. "IMPROVED PREPARATION OF PENICILLIN N AND ISOPENICILLIN N." Organic Preparations and Procedures International 20, no. 5 (October 1988): 497–503. http://dx.doi.org/10.1080/00304948809356295.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Jensen, Susan E., Brenda K. Leskiw, Leo C. Vining, Yair Aharonowitz, Donald W. S. Westlake, and Saul Wolfe. "Purification of isopenicillin N synthetase from Streptomyces clavuligerus." Canadian Journal of Microbiology 32, no. 12 (December 1, 1986): 953–58. http://dx.doi.org/10.1139/m86-176.

Full text
Abstract:
Isopenicillin N synthetase was purified from Streptomyces clavuligerus by sequential salt precipitation, ion-exchange and gel-filtration chromatography using both conventional open column and high-performance liquid chromatographic techniques. Material from the final purification step had a specific activity of 204.1 × 10−3 units/mg of protein which represented a 130-fold purification over the cell-free extract. The purified isopenicillin N synthetase was determined to have a molecular weight of 33 000 by sodium dodecyl sulfate – polyacrylamide gel electrophoresis and to have a Km of 0.32 mM with respect to its substrate δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine. The enzyme showed a sensitivity to thiol-specific inhibitors with N-ethylmaleimide giving the strongest inhibitory effect.
APA, Harvard, Vancouver, ISO, and other styles
10

Loke, Paxton, and Tiow-Suan Sim. "Mutational analysis of conserved glycines 42 and 256 in Cephalosporium acremonium isopenicillin N synthase." Canadian Journal of Microbiology 47, no. 10 (October 1, 2001): 961–64. http://dx.doi.org/10.1139/w01-101.

Full text
Abstract:
Isopenicillin N synthase (IPNS) is critical for the catalytic conversion of δ -(L-α-aminoadipoyl)-L-cysteinyl-D-valine to isopenicillin N in the penicillin and cephalosporin biosynthetic pathway. Two conserved glycine residues in Cephalosporium acremonium IPNS (cIPNS), namely glycine-42 and glycine-256, were identified by multiple sequence alignment and investigated by site-directed mutagenesis to study the effect of the substitution on catalysis. Our study showed that both the mutations from glycine to alanine or to serine reduced the catalytic activity of cIPNS and affected its soluble expression in a heterologous host at 37°C. Soluble expression was restored at a reduced temperature of 25°C, and thus, it is possible that these glycine residues may have a role in maintaining the local protein structure and are critical for the soluble expression of cIPNS.Key words: isopenicillin N synthase, site-directed mutagenesis, glycine, Cephalosporium acremonium.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Isopenicillin N"

1

Fujishima, Yoshiyuki. "Studies on isopenicillin N synthase." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305979.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Bradley, Mark. "Mechanism of isopenicillin N synthase." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236117.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Furuse, Reiko. "Mechanistic investigations into isopenicillin N synthase." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305450.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Daruzzaman, Adam. "Mechanistic studies on isopenicillin N synthase." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289399.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Turner, N. J. "Mechanistic studies on isopenicillin N synthase." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355820.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Abbott, Shaun Douglas. "Mechanistic studies on isopenicillin N synthase." Thesis, University of Oxford, 1991. https://ora.ox.ac.uk/objects/uuid:0124fa37-2d7a-43b5-a3e9-c49be4125be2.

Full text
Abstract:
The mechanism of penicillin formation through the action of the enzyme isopenicillin N synthase (IPNS) on the substrate δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine and synthetic analogues, still raises many unresolved questions, despite many years' extensive investigation. In order to investigate the stereochemistry of formation of the second ring in the product, N-δ-(L-α-aminoadipoyl)-3α-hydroxymethylpenicillin, resulting from incubation of δ-(L-α-aminoadipoyl)- L-cysteinyl-D-vinylglycine with IPNS, the deuterium labelled tripeptides δ-(L-α-aminoadipoyl)- L-cysteinyl-E-[3,4-2H2]-D-vinylglycine and δ-(L-α-aminoadipoyl)-L-cysteinyl- Z-[3,4-2H2]-D-vinylglycine were synthesised and incubated with recombinant IPNS. The pattern of deuterium labelling was retained in the penam products, indicating stereospecific ring closure. The unlabelled and labelled penicillins were converted to their corresponding γ-lactones, and the 1H NMR coupling constants for the C(3)H-C(8)H2 system used to assign the 8-Pro/? and 8-ProS resonances of the unlabelled lactone. Comparison with the labelled lactones indicated that the parent penicillins had been formed via syn addition of sulphur and oxygen across the double bonds of the respective tripeptides. This stereochemistry is consistent with a mechanism involving [2πs + 2π] cycloaddition of an Fe=O species to the olefln.
APA, Harvard, Vancouver, ISO, and other styles
7

Fung, Kwok Wing. "Models and mimics of Isopenicillin N Synthase." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335777.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Pitt, A. R. "Stereochemistry and mechanism of isopenicillin N synthase." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235052.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Brown, Toby James Neville. "Analytical studies of some amino acid secondary metabolism." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300806.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Fletcher, Clare Alison. "Studies on the mechanism of isopenicillin-n-synthase." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239289.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Isopenicillin N"

1

Martín, Juan F., Ricardo V. Ullán, and Javier Casqueiro. "Novel Genes Involved in Cephalosporin Biosynthesis: The Three-component Isopenicillin N Epimerase System." In Molecular Biotechnolgy of Fungal beta-Lactam Antibiotics and Related Peptide Synthetases, 91–109. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/b99258.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

"Isopenicillin-N epimerase." In Class 4–6 Lyases, Isomerases, Ligases, 481–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-85707-5_98.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Isopenicillin N' for particular source types:
Journal articles Dissertations / Theses
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography