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Dissertations / Theses on the topic 'Isoflurane'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Bradshaw, Jennifer Jean. "Isoflurane : interaction with hepatic microsomal enzymes." Doctoral thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/27138.

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lsoflurane interacts with cytochrome P-450 in rat and human hepatic microsomes and the Δ6- and Δ5-desaturases in rat hepatic microsomes. The interaction of isoflurane with cytochrome P-450 results in its metabolism to fluoride ion and organofluorine metabolites. The cytochrome P-450 isozymes catalysing the defluorination of isoflurane were assessed in hepatic microsomes from phenobarbital-, β-naphthoflavone- and pregnenolone-16α-carbonitrilepretreated and untreated rats. One or more of the cytochrome P-450 isozymes induced by phenobarbital and pregnenolone-16α-carbonitrile appear to defluorina

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2

Jaensch, Susan Mary. "Studies on isoflurane anaesthesia in psittacine birds." Thesis, Jaensch, Susan Mary (2001) Studies on isoflurane anaesthesia in psittacine birds. PhD thesis, Murdoch University, 2001. https://researchrepository.murdoch.edu.au/id/eprint/53177/.

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The aim of the studies reported in this thesis was to describe the effects of isoflurane anaesthesia on the hepatic and respiratory systems in psittacine birds, as these are the two most commonly compromised organ systems during human anaesthesia. The results of these studies will lead to improved understanding of avian anatomy and physiology, and improvement of the current methodologies of anaesthesia administration. Galactose and indocyanine green (ICG) clearances assays were compared with plasma and serum biochemical markers of liver dysfunction in normal chickens and galahs. following

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3

Mukaida, Kumiko. "Activity of the serotonergic system during isoflurane anesthesia." Kyoto University, 2007. http://hdl.handle.net/2433/135747.

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4

Miu, Peter. "Isoflurane induced impairment of synaptic transmission in hippocampal neurons of the guinea pig in vitro." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28027.

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The effects of anaesthetic applications of isoflurane on 82 CA₁ neurons were studied in in vitro preparations (guinea pigs) using intracellular recording techniques. Various parameters of their excitability such as membrane electrical properties, action potentials and their afterhyperpolarizing potentials as well as synaptic transmission were determined during bath perfusion of clinically relevant concentrtaions of isoflurane. Concentrations of isoflurane were detected in the bath with ¹⁹fluorine nuclear magnetic resonance techniques, and were found to range between 0.02 and 0.3 mM. No

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5

Adachi, Lauren Naomi Spezia. "Avaliação dos efeitos da acupuntura e da eletroacupuntura em modelo animal de dor neuropática : parâmetros comportamentais e bioquímicos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/169683.

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Dor neuropática (DN) é definida como “dor iniciada ou causada por lesão primária ou disfunção em sistema nervoso”, porém sua prevalência depende do tipo de trauma e da disfunção relacionada. Apesar desta condição dolorosa ser considerada altamente prevalente e debilitante, os tratamentos disponíveis são relacionados a efeitos adversos dificultando a adesão. Devido a isso, buscam-se alternativas não farmacológicas para o tratamento deste tipo de dor, entre elas, as técnicas de neuromodulação periférica, como acupuntura (AC) e eletroacupuntura (EA). Estas técnicas podem ser combinadas com interv

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6

Sackey, Peter V. "Inhaled sedation with isoflurane in the intensive care unit /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-962-9/.

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7

Brosnan, Robert Joseph. "Intracranial and cerebral perfusion pressures in isoflurane-anesthetized horses /." Connect to Digital dissertations. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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8

Païta, Lucille. "Caractérisation du canal cationique TRPV1 dans les cardiomyocytes." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1329/document.

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L'infarctus du myocarde, une des causes majeures de mortalité à travers le monde, engendre une mort irréversible du muscle cardiaque suite à une ischémie. Cette ischémie, c'est-à-dire une privation de dioxygène et de nutriments, déclencher un stress réticulaire qui perturbe l'équilibre calcique de la cellule cardiaque. Plusieurs pompes et canaux calciques situés à la membrane plasmique ou réticulaire sont des intervenants clés dans le maintien de l'homéostasie calcique. Parmi eux, il existe des canaux de fuites calciques passives, comme les TRPs, et peu d'informations sont actuellement connus

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9

Decorps, Anne. "Etude pharmacoéconomique en anesthésie : impact économique d'un réveil rapide après anesthésie au desflurane : étude coût-efficacité." Paris 5, 1999. http://www.theses.fr/1999PA05P156.

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10

Ferron, Judy-Fay, and Judy-Fay Ferron. "Étude in vivo du "burst-suppression"." Master's thesis, Université Laval, 2009. http://hdl.handle.net/20.500.11794/21020.

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Tableau d’honneur de la Faculté des études supérieures et postdoctorales, 2009-2010<br>Tableau d’honneur de la Faculté des études supérieures et postdoctorales, 2009-2010<br>Cette étude résume certains concepts liés à l’anesthésie générale, détaille les mécanismes d’action de l’isoflurane, un anesthésiant volatil, et aborde le phénomène du burst-suppression. Elle vise principalement la compréhension de l’impact de l’isoflurane, à des doses amenant le burst-suppression, sur l’inhibition dans le réseau thalamo-cortical. Nous effectuons des enregistrements intracellulaires de neurones corticaux i

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11

Rocha, Thalita Leone Alves. "Avaliação do status antioxidante, das citocinas inflamatórias e metaloproteinases em ratos anestesiados com isoflurano ou sevoflurano." Botucatu, 2018. http://hdl.handle.net/11449/180509.

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Orientador: Carlos Alan Candido Dias Junior<br>Resumo: O presente estudo teve por objetivo investigar e comparar as alterações relacionadas à reatividade vascular e aos biomarcadores de estresse oxidativo e da inflamação em ratos anestesiados com isoflurano ou sevoflurano. Para alcançar nossos objetivos, ratos Wistar machos adultos foram distribuídos aleatoriamente em três grupos experimentais: não anestesiado (grupo controle) e anestesiados com isoflurano (grupo Iso) ou sevoflurano (grupo Sevo). A responsividade vascular à fenilefrina (PHE) e acetilcolina (ACh) na presença ou ausência de éste

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12

Northing, Richard J. "An electrochemical sensor for forane." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:4b9a19f1-919c-4fc1-a39b-8bb3ac706f9f.

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This thesis is concerned with the development and laboratory assessment of an electrochemical sensor for the detection and measurement of the volatile inhalation anaesthetic, forane. Investigations were therefore based on the heterogeneous and homogeneous reduction of this agent in non-aqueous electrolyte. Preliminary experiments at a mercury and other rotating disc electrodes (RDEs) revealed that the direct reduction of forane was not possible and therefore the use of an electron transfer mediator was examined. To this end, the radical anion of the polyaromatic compound, fluoranthene, (F), wa

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13

Goddard, Helen. "Electrophysiological effects of fentanyl, halothane and isoflurane on guinea-pig isolated ventricular myocytes." Thesis, University of Oxford, 2002. http://ora.ox.ac.uk/objects/uuid:58f6f4e2-aaa9-4913-a7c2-5568e2f8d72f.

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14

Aarnes, Turi K. "Fluid administration for the treatment of isoflurane-induced hypotension in dogs." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1236023502.

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15

Zambelli, Fábio Poças [UNESP]. "O isoflurano e a associação remifentanil e isoflurano usados após isquemia reperfusão causa proteção renal em ratos?" Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/105377.

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Made available in DSpace on 2014-06-11T19:34:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-12-17Bitstream added on 2014-06-13T20:25:37Z : No. of bitstreams: 1 zambelli_fp_dr_botfm.pdf: 1509094 bytes, checksum: e6de84501fc2a502a433a545bd00c50d (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Há fármacos que produzem pré-condicionamento farmacológico e, dentre estes, os anestésicos inalatórios são os mais estudados. Como exemplo, o isoflurano pode proteger o rim contra a lesão causada pela isquemiareperfusão, principalmente quando a anestesia inalatór

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16

Mosley, Craig A. E. "Evaluation of isoflurane and butorphanol in the green iguana (Iguana iguana)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/MQ55696.pdf.

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17

Aarnes, Turi Kenna. "Fluid administration for the treatment of isoflurane-induced hypotension in dogs." Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1236023502.

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18

Zambelli, Fábio Poças. "O isoflurano e a associação remifentanil e isoflurano usados após isquemia reperfusão causa proteção renal em ratos? /." Botucatu : [s.n.], 2010. http://hdl.handle.net/11449/105377.

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Orientador: Pedro Thadeu Galvão Vianna<br>Banca: Luiz Vicente Garcia<br>Banca: Luiz Antonio Vane<br>Banca: Rosa Beatriz Amorim<br>Banca: Angélica de Fátima de Assunção Braga<br>Resumo: Há fármacos que produzem pré-condicionamento farmacológico e, dentre estes, os anestésicos inalatórios são os mais estudados. Como exemplo, o isoflurano pode proteger o rim contra a lesão causada pela isquemiareperfusão, principalmente quando a anestesia inalatória é mantida por um período após a reperfusão. Os opióides parecem ser uma classe de fármacos capaz de produzir este pré-condicionamento. Há estudo most

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19

Guénard, Yves. "Etude prospective, contrôlée sur les conséquences de la prescription d'anthracyclines sur l'inotropisme ventriculaire gauche au cours de l'anesthésie générale sous isoflurane : mise en place du protocole." Bordeaux 2, 1999. http://www.theses.fr/1999BOR23011.

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20

BRODIER, CATHERINE. "Anesthesie pour chirurgie des fentes labio-palatines en pediatrie : interet de l'isoflurane dans une etude comparee : a propos de 100 cas." Reims, 1989. http://www.theses.fr/1989REIMM093.

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21

FOUILLARD, FRIOUX ANNE. "Le propofol dans la chirurgie du carrefour aortique : comparaison avec l'isoflurane." Limoges, 1989. http://www.theses.fr/1989LIMOO115.

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22

Darling, John R. "The effects of halothane, isoflurane and sevoflurane on hepatic and renal function." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261937.

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23

Moutinho, Inês Isabel Mano. "Estudo comparativo dos anestésicos sevoflurano vs isoflurano em coelhos (Oryctolagus cuniculi)." Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2010. http://hdl.handle.net/10400.5/2264.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A introdução de espécies exóticas na prática clínica veterinária exige uma actualização constante nesta área. A anestesia é, muitas vezes, necessária para a elaboração de procedimentos de rotina nestes animais. Os anestésicos mais utilizados neste âmbito são os anestésicos voláteis, devido às suas características farmacológicas. São eliminados, principalmente pelos pulmões, evitando assim a formação de metabolitos tóxicos noutros órgãos. Possuem ainda um baixo coeficiente de solubilidade sangue/gás, permitindo uma rápida indução e re

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24

Cesarovic, Nikola. "Acute and long-term effects of isoflurane and sevoflurane anaesthesia in laboratory mice /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000278505.

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25

Hirata, Shinichi. "Effects of isoflurane on receptor-operated Ca2+ channels in rat aortic smooth muscle." Kyoto University, 2000. http://hdl.handle.net/2433/180893.

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26

Pimenta, Eutálio Luiz Mariani. "Determinação da variação da pressão de pulso em equinos anestesiados com isofluorano e mecanicamente ventilados submetidos à reposição volêmica." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-07102016-122248/.

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Objetivo: Determinar a relação entre a ΔPP e a responsividade à expansão volêmica em equinos anestesiados com isoflurano e mecanicamente ventilados. Método: Em estudo prospectivo, oito cavalos Árabes saudáveis (366,5 ± 22,7kg) foram anestesiados. Todos os animais foram aleatoriamente alocados em dois grupos: (I) restrição hídrica de 14h; (II) restrição hídrica de 14h mais pneumoperitôneo de 12mmHg. Anestesia foi induzida com detomidina, diazepam e cetamina e mantida com isoflurano a 1,6% (I) e 1,3 % (II) em todos os animais mecanicamente ventilados (VTexp 14mL/kg) e posicionados em d

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27

WALLECK, PATRICIA. "Comparaison de deux protocoles anesthesiques lors des coelioscopies de longue duree chez le porc." Clermont-Ferrand 1, 1992. http://www.theses.fr/1992CLF13835.

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28

Wood, Melinda Anne. "The Effects of Anesthesia and Surgery on Thyroid Function Tests in Dogs." Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/43705.

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Background: Many non-thyroidal factors affect thyroid function tests. Anesthesia and surgery have been documented to affect thyroid function tests in humans but have not been extensively studied in dogs. Hypothesis: Anesthesia alone and anesthesia combined with surgery will affect thyroid function tests in dogs. Animals: 15 euthyroid mongrel dogs. Methods: Dogs were assigned to one of three groups: control, general anesthesia, and general anesthesia plus abdominal exploratory surgery. Blood samples were collected from each dog immediately prior to pre-medication, 20 minutes after pre-medi

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29

Erasso, Diana Marcela. "Differential Effects of Isoflurane and Propofol Anesthesia on Neurogenesis in Young and Aged Rats." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3092.

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Worldwide, millions of young and elderly patients receive procedures that could not be performed without the use of anesthetics. Unfortunately, emerging animal and human data suggest an association between exposure to general anesthesia and impairment of cognitive function in pediatric and geriatric patients. Recent laboratory data have shown that general anesthetics are potentially damaging to the developing and aging brain. However, the mechanism by which this happens is still unknown. General anesthetics affect learning and memory, a brain function involving neural plasticity. An important

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30

Fujinaga, Takuji. "Isoflurane inhalation after circulatory arrest protects against warm ischemia reperfusion injury of the lungs." Kyoto University, 2007. http://hdl.handle.net/2433/135895.

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31

Dessen, Marina Regatieri [UNESP]. "Efeitos do citrato de sufentanil, administrado em infusão contínua, na concentração alveolar mínima (CAM) de isofluorano em felinos." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/86630.

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Made available in DSpace on 2014-06-11T19:22:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-04-26Bitstream added on 2014-06-13T19:07:45Z : No. of bitstreams: 1 dessen_mr_me_botfmvz.pdf: 386204 bytes, checksum: a84656fdadfb9ae9018f3007e5844e9b (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Opioides reduzem a CAM de agentes inalatórios em diversas espécies. O objetivo do presente estudo foi avaliar o efeito de três doses de sufentanil ,administradas em infusão contínua, na CAMiso em fel

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32

David, Jean-Stéphane. "Étude in vitro de l'effet sur myocarde sain et pathologique d'agents de l'anesthésie." Lyon 1, 2006. http://www.theses.fr/2006LYO10034.

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Les effets de différents produits de l'anesthésie ont été étudiés à l'aide d'un modèle de muscle papillaire. Chez le rat, la protamine a induit un effet inotrope négatif marqué qui s'accompagnait d'une contracture du muscle probablement en relation avec une surcharge calcique intracytosolique. De plus, la réponse inotrope aux agonistes α- et β- adrénergiques était abolie alors que la réponse lusitrope était préservée, suggérant une action en aval de la chaine des phosphorylations AMPc dépendante. Sur le myocarde diabétique, l'effet des gaz halogénés était plus important et en relation avec une

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33

De, Sousa Sara Luisa Mellor. "Effects of the general anaesthetics isoflurane and xenon on synaptic transmission in isolated hippocampal neurones." Thesis, Imperial College London, 1999. http://hdl.handle.net/10044/1/8593.

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34

McKinney, Maurice Stanley. "Aspects of cardiac function and the influence of age during anaesthesia with isoflurane and halothane." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333778.

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35

Buck, Roxanne Kate. "Cardiopulmonary effects of anaesthesia maintained by propofol infusion versus isoflurane inhalation in cheetah (Acinonyx jubatus)." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/65506.

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Objective To compare the cardiopulmonary function of cheetahs (Acinonyx jubatus) undergoing propofol total intravenous anaesthesia (TIVA) to isoflurane maintenance in order to evaluate their feasibility for field use. Study design Prospective clinical study Animals 24 adult cheetahs Materials and Methods Cheetahs were immobilised with tiletamine-zolazepam (1.2 mg kg-1) and medetomidine (40 ?g kg-1) intramuscular by darting. A maintenance protocol of propofol TIVA (Group-P) or isoflurane inhalation (Group-I) was randomly assigned to each cheetah. Anaesthesia was maintained for at least 60 minut

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36

Loughran, Claire. "The effect Dobutamine and Bolus crystalloid fluids on the cardiovascular function of isoflurane anaesthetised horses." Thesis, Loughran, Claire (2016) The effect Dobutamine and Bolus crystalloid fluids on the cardiovascular function of isoflurane anaesthetised horses. Masters by Research thesis, Murdoch University, 2016. https://researchrepository.murdoch.edu.au/id/eprint/32825/.

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Reason for performing the study: Cardiac output does not always increase with dobutamine administration in anaesthetised horses and information on peripheral perfusion is lacking. Objective: Determine the effect of intravenous dobutamine infusion with and without a concurrent 20 mL kg-1 bodyweight bolus of crystalloid fluids on the cardiovascular function of hypotensive, isoflurane-anaesthetised horses premedicated with acepromazine. Study design: Prospective, randomised, crossover experimental design. Methods: Six horses aged 5-13 years, weighing 464-578 kg were premedicated with

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37

Piriou, Vincent. "Interactions entre l'isoflurane et un activateur des canaux Katp (le nicorandil) : effets sur l'hémodynamique et sur la cardioprotection." Lyon 1, 1999. http://www.theses.fr/1999LYO1T088.

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38

Keita, Alassane Ndeye Sokhna. "Etude d'un modèle de neuropaludisme chez le rat et évaluation des effets pharmacologiques d'un candidat-médicament." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30379.

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Le neuropaludisme (NP) est la forme la plus mortelle du paludisme. C'est une complication neurologique observée uniquement dans les cas d'infection par Plasmodium falciparum, principalement chez les enfants de moins de 5 ans vivant en Afrique Sub-saharienne, et les adultes non-immuns, notamment les femmes enceintes et les touristes visitant les zones d'endémie. Les signes cliniques sont à présent bien décrits (prostration, convulsions répétées, difficultés respiratoires, coma,...), mais les mécanismes physiopathologiques conduisant au NP sont encore mal définis. Leur élucidation est rendue dif

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39

Carraretto, Antonio Roberto [UNESP]. "Estudo da proteção renal com propofol e o isoflurano durante a esquemia e a reperfusão, com hiperglicemia transitória." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/106011.

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Made available in DSpace on 2014-06-11T19:35:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-24Bitstream added on 2014-06-13T19:05:31Z : No. of bitstreams: 1 carraretto_ar_dr_botfm.pdf: 822756 bytes, checksum: d39d7bb3ab7eed1fb356cccaf87705ec (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A hiperglicemia aumenta a lesão renal na isquemiareperfusão em ratos anestesiados com isoflurano (Iso). Este efeito é desconhecido com o uso do propofol (Prop). O objetivo desse estudo é avaliar o efeito do isoflurano (Iso) e do propofol na lesão renal de isquem

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40

Dessen, Marina Regatieri. "Efeitos do citrato de sufentanil, administrado em infusão contínua, na concentração alveolar mínima (CAM) de isofluorano em felinos /." Botucatu : [s.n.], 2010. http://hdl.handle.net/11449/86630.

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Orientador: Antonio José Araújo Aguiar<br>Banca: Suzane Lilian Beier<br>Banca: Stelio Pacca Loureiro Luna<br>Resumo: Opioides reduzem a CAM de agentes inalatórios em diversas espécies. O objetivo do presente estudo foi avaliar o efeito de três doses de sufentanil ,administradas em infusão contínua, na CAMiso em felinos. Oito gatos adultos e castrados (4.0±0.5 kg-1) foram anestesiados com isofluorano em três ocasiões distintas com um intervalo mínimo de sete dias mantidos em ventilação mecânica. A temperatura esofágica foi mantida na faixa de 38.5 a 39.0°C. Uma das três doses de sufentanil (0.0

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41

Oshiro, Alexandre Hideaki. "Avaliação da variação de pressão de pulso (VPP) frente a diferentes concentrações inaladas de isoflurano, desflurano e sevoflurano: modelo experimental em suínos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-27032013-111704/.

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Introdução: Os anestésicos inalatórios empregados atualmente na prática clinica (isoflurano, sevoflurano e desflurano) possuem propriedades farmacocinéticas que favorecem rápida recuperação da anestesia, porém seu uso pode causar instabilidade hemodinâmica dose-dependente, relacionado à depressão direta da contratilidade miocárdica ou à hipovolemia relativa, derivado de um sequestro de sangue devido à vasodilatação do leito vascular periférico. Este estudo visa avaliar o comportamento da VPP durante a anestesia inalatória. Para tanto se utilizou três diferentes agentes inalatórios (isoflurano,

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42

Sams, Lisa Michelle. "The Effect of Morphine-Lidocaine-Ketamine-Dexmedetomidine Co-infusion on Minimum Alveolar Concentration of Isoflurane in Dogs." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306860828.

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43

Mariam, Tasnuva. "Burst-suppression events and fast, large-amplitude, sharp waves in the cortical EEG during deep isoflurane coma." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54331.

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44

Spencer, Elizabeth Mary. "The sedation of patients requiring prolonged mechanical ventilation in the intensive therapy unit : the role of isoflurane." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387127.

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Enderle, Alke Karen. "Clinical evaluation of ketamine and lidocaine intravenous infusions to reduce isoflurane requirements in horses under general anaesthesia /." Bern : [s.n.], 2006. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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Pottie, Robert George. "A CLINICAL STUDY OF INHALANT ANAESTHESIA IN DOGS." University of Sydney, 2004. http://hdl.handle.net/2123/559.

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A clinical trial was undertaken using three different inhalant anaesthetic agents and one intravenous anaesthetic agent in dogs undergoing routine desexing surgery. Healthy adult dogs undergoing either ovariohysterectomy or castration were assessed as to their demeanour, with the more excitable dogs being placed in groups receiving premedication with acepromazine and morphine. All dogs were then randomly assigned an anaesthetic agent for induction of general anaesthesia. The agents were the inhalants halothane, isoflurane and sevoflurane, and the intravenous agent propofol. Inhalant inductio

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Dunningham, Helen. "Modelling lung and tissue gas transfer using a membrane oxygenator circuit : determining the effects of a volatile anaesthetic agent and a haemoglobin substitute on oxygen, carbon dioxide and nitric oxide diffusion." Thesis, Anglia Ruskin University, 2011. http://arro.anglia.ac.uk/211595/.

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A novel in vitro membrane oxygenator circuit was developed to test gas exchange where particular elements could be examined whilst keeping other variables constant. The circuit comprises two membrane oxygenators connected to form a continuous blood circuit resembling venous and arterial blood conditions. The effects of Isoflurane, a volatile anaesthetic, on oxygen transfer were investigated. RBC resistance to nitric oxide diffusion (DNO) was tested in this circuit by haemolysis and addition of the haemoglobin-based-oxygen-carrier (HBOC) Oxyglobin. The circuit was primed with equine blood flowi

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48

Dunningham, Helen. "Modelling lung and tissue gas transfer using a membrane oxygenator circuit; determining the effects of a volatile anaesthetic agent and a haemoglobin substitute on oxygen, carbon dioxide and nitric oxide diffusion." Thesis, Anglia Ruskin University, 2011. https://arro.anglia.ac.uk/id/eprint/211595/1/Dunningham_Thesis_2011.pdf.

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Abstract:

A novel in vitro membrane oxygenator circuit was developed to test gas exchange where particular elements could be examined whilst keeping other variables constant. The circuit comprises two membrane oxygenators connected to form a continuous blood circuit resembling venous and arterial blood conditions. The effects of Isoflurane, a volatile anaesthetic, on oxygen transfer were investigated. RBC resistance to nitric oxide diffusion (DNO) was tested in this circuit by haemolysis and addition of the haemoglobin-based-oxygen-carrier (HBOC) Oxyglobin. The circuit was primed with equine blood flowi

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Gatecel, Claire. "Incidence de l'halothane et de l'isoflurane sur les debits sanguins arteriels hepatiques et veineux porte chez l'homme mesures par methode doppler pulse avec microcapteurs implantes : validation de la methode." Rennes 1, 1992. http://www.theses.fr/1992REN1M022.

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Pillai, Aditi. "Effects of Body Temperature and General Anesthetics on Intraocular Pressure in Rats." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7351.

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Ocular hypertension has been identified as the fundamental risk factor in glaucoma which is the leading cause for irreversible blindness in the world. Understanding the different factors that affect IOP is of utmost importance in clinical management as IOP is considered as the fundamental factor in assessing the efficiency of glaucoma medications. Several studies have attempted to assess factors that could affect IOP including age, body position, blood pressure, anesthetics commonly used during eye operations, etc. However, in most of these studies IOP is measured under anesthesia using rodent

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