Relevant bibliographies by topics / Isoflavones

Academic literature on the topic 'Isoflavones'

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Published: 4 June 2021
Last updated: 31 August 2024

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Journal articles on the topic "Isoflavones"

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Hernández, Brandón, María del Carmen Cruz, Omar Gómez, Elvia Becerra, Fabiola Eloisa Jiménez, and Aaron Mendieta. "Alpha-glucosidase and Alpha-amylase Inhibitors Derived from Naturally Occurring Prenylated Isoflavones." Journal of the Mexican Chemical Society 68, no. 1 (January 1, 2024): 156–69. http://dx.doi.org/10.29356/jmcs.v68i1.2129.

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A series of prenylated isoflavones were synthesized to evaluate their inhibitory effect against α-glucosidase and α-amylase enzymes, analyzing the bioisosteric effect of the linear or cyclized prenyl moiety in these benzopyran derivatives. Compound 5a exhibited higher α-glucosidase inhibition (IC50 = 60.5 µM) and lower α-amylase inhibition (IC50 = 85.0 µM) compared to acarbose (IC50 = 527.5 µM for α-glucosidase and 20.1 µM for α-amylase). In contrast, prenylated isoflavone 5c showed higher inhibition in both enzymes (IC50 = 17.6 µM for α-glucosidase and 21.2 µM for α-amylase). This suggests that the attachment of a prenyl moiety to the 7-hydroxy group of isoflavone provides higher inhibition in the enzymes α-glucosidase and α-amylase. Docking studies of compounds 5a and 5c displayed key interactions towards both enzymes. The type of inhibition for 5c was analyzed, where the results indicate a competitive inhibition of both α-glucosidase and α-amylase. Finally, ADMET studies support that compounds 5a and 5c are candidates for the design of novel isoflavones derivatives with antidiabetic potential. Resumen. Una serie de isoflavonas preniladas se sintetizaron para evaluar su efecto inhibidor sobre las enzimas α-glucosidasa y α-amilasa, analizando el efecto bioisotérico del fragmento prenilo tipo lineal o ciclado en estos benzopiranos derivados. El compuesto 5a exhibió una inhibición alta de α-glucosidasa (CI50 = 60.5 µM) y una inhibición más baja de α-amilasa (CI50 = 85.0 µM, respectivamente) en comparación con acarbosa (CI50 = 527.5 y 20.1 µM). La isoflavona prenilada 5c mostró mayor inhibición en ambas enzimas (CI50 = 17.7 µM para α-glucosidasa y 21.2 µM para α-amilasa). Esto sugiere que la unión del fragmento prenilo al hidroxilo de la posición 7 de la isoflavona ocasiona una mayor inhibición en las enzimas α-glucosidasa y α-amilasa. Los compuestos 5a y 5c mostraron interacciones clave hacia el sitio activo de ambas enzimas, de acuerdo con los cálculos de acoplamiento. Se analizó el tipo de inhibición para 5c, donde los resultados indican una inhibición competitiva tanto de α-glucosidasa como de α-amilasa. Finalmente, los estudios ADMET respaldan que los compuestos 5a and 5c son candidatos para el diseño de nuevos derivados de isoflavonas con potencial antidiabético.
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Matsjeh, Sabirin, Chairil Anwar, Eti Nurwening Solikhah, Andi Hairil Alimuddin, and Anggie Sitta Pradhanti. "Synthesis Isoflavones Derivate: 7-Hydroxy-3',4’-Dimethoxyisoflavone, 7,3’,4’-Trimethoxyisoflavone and 7-O-Acetyl-3’,4’-Dimethoxyisoflavone." Materials Science Forum 901 (July 2017): 118–23. http://dx.doi.org/10.4028/www.scientific.net/msf.901.118.

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Some Isoflavones 7-hydroxy-3',4'-dimethoxyisoflavone (2), 7,3',4'-trimethoxyisoflavone (3) and 7-O-acetyl-3',4'-dimethoxyisoflavone (4) have been synthesized through cyclization reaction of deoxybenzoine using a reagent mixture BF3.Et2O , DMF and POCl3. The DMF reagent was added aiming to add one carbon to form isoflavone 1. The deoxybenzoine (3,4-dimethoxybenzyl-2', 4'-dihydroxyphenylketone, (1) was synthesized by reacting 3,4-dimethoxy benzyl carboxylic acid and resorcinol through Friedel Craft acylation using a Lewis acid (BF3) as a catalyst. The isoflavones 1 was converted into isoflavone 2 via methylation reaction using dimethylsulfate (DMS) and K2CO3 and conversions into isoflavone3 through acetylation reaction using acetylchloride. The results were analyzed using FTIR, GC-MS and 1H NMR spectrometers. Deoxybenzoine derivatives of 3,4-dimethoxybenzyl-2',4'-dihydroxy phenylketone was yielded in 57% with m.p 171-172 °C. The isoflavone 1, 2 and 3 was produced in 58, 52 and 53 % yield, respectively.
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Song, Sihan, Hyeong-Gon Moon, Dong-Young Noh, So-Youn Jung, Eun Sook Lee, Zisun Kim, Hyun Jo Youn, et al. "Dietary Intake and Plasma Levels of Isoflavones Among Breast Cancer Survivors." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 1490. http://dx.doi.org/10.1093/cdn/nzaa061_118.

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Abstract Objectives Isoflavones, rich in soybeans, are phytoestrogens with a similar chemical structure to estrogen and their roles in breast cancer prognosis remains equivocal. We aimed to estimate dietary intake of isoflavones and soy and examine their correlations with plasma levels of isoflavones among Korean breast cancer survivors. Methods A total of 974 female breast cancer survivors (mean age, 52 years) were included in the cross-sectional study. We estimated dietary intake of soy and isoflavones using either a 3-day food record (3DR; n = 645) or a food frequency questionnaire (FFQ; n = 329). Plasma isoflavone levels were measured by liquid chromatography methods in 439 participants. We calculated total isoflavones by summing daidzein, genistein, and glycitein. We estimated % contribution of food sources to dietary isoflavone intake and Pearson correlation coefficients with plasma isoflavone levels. We calculated de-attenuated correlations among those who reported dietary intake using 3DRs to reduce within-person variation (n = 233). Results The mean daily intake of total isoflavones among Korean breast cancer survivors was 21.91 mg/d. The major sources were tofu (% contribution = 30.6%), soybean (14.2%), and soybean sprouts (12.8%). The correlation coefficients with plasma isoflavone levels were 0.19 for dietary isoflavone intake and 0.18 for soy and its products intake. The de-attenuated correlation coefficients with plasma isoflavone levels were 0.25 for dietary isoflavone intake and 0.35 for soy and its products intake. When we examined the correlation between specific type of isoflavone and circulating level of each isoflavone, the de-attenuated correlation coefficients were 0.18 for daidzein, 0.28 for genistein, and 0.25 for glycitein. Conclusions We found the highest contribution from tofu and soybean to dietary isoflavone intake and moderate correlations of dietary intakes of soy and isoflavones with plasma levels of isoflavones among Korean breast cancer survivors. Our study warrants further investigation on the roles of isoflavones in breast cancer prognosis. Funding Sources This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science and ICT, MSIT) (No. 2019R1F1A1061017).
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Mantovani, Daniel, Aline Takaoka Alves Baptista, Charleston De Oliveira Bezerra, Driano Rezende, Luis Fernando Cusioli, and Paulo Fernando Soares. "MÉTODO DE VALIDAÇÃO E SEPARAÇÃO DE ISOFLAVONAS PRESENTES EM MELAÇO DE SOJA." e-xacta 11, no. 1 (June 15, 2018): 97. http://dx.doi.org/10.18674/exacta.v11i1.2347.

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<p><em>As isoflavonas atuam no organismo humano com efeitos fisiológicos de forma benéfica tornando os alimentos que contém isoflavonas em formas funcionais ao organismo. Assim, neste trabalho foi desenvolvido um método de análise por Cromatografia Líquida de Alta Eficiência (CLAE) bem como, separação e quantificação de isoflavonas presentes no melaço de soja. A validação do método foi baseada pela linearidade, limite de detecção (LD) e limite de quantificação (LQ) com estabelecimentos de critérios de análise para aceitação da metodologia proposta. Os resultados obtidos na separação dos isômeros de isoflavonas bem como a quantificação trouxeram melhorias relacionadas ao tempo de retenção de cada isômero estudado e separação dos compostos. Com relação ao método aplicado ao longo do estudo este apresentou resultados pertinentes para utilização e expansão do método proposto focado nos compostos de isoflavonas formas glicosídicas e agliconas presentes no melaço de soja.</em></p><p> </p><p><em>ABSTRACT</em></p><p><em>Isoflavones act in the human body with physiological effects in a beneficial way making foods containing isoflavones in functional forms to the body. Thus, in this work a high efficiency liquid chromatography (HPLC) analysis method was developed, as well as, separation and quantification of isoflavones from in soybean molasses. The validation of the method was based on linearity, limit of detection (LD) and limit of quantification (LQ) with establishments of analysis criteria for acceptance of the proposed methodology. The results obtained in the separation of the isoflavone isomers as well as the quantification brought improvements related to the retention time of each studied isomer and separation of the compounds. In relation to the method applied throughout the study, it presented relevant results for the use and expansion of the proposed method focused on the isoflavone compounds glycosidic forms and aglycones from soybean molasses.</em></p>
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Soukup, Sebastian T., Ann Katrin Engelbert, Bernhard Watzl, Achim Bub, and Sabine E. Kulling. "Microbial Metabolism of the Soy Isoflavones Daidzein and Genistein in Postmenopausal Women: Human Intervention Study Reveals New Metabotypes." Nutrients 15, no. 10 (May 17, 2023): 2352. http://dx.doi.org/10.3390/nu15102352.

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Background: Soy isoflavones belong to the group of phytoestrogens and are associated with beneficial health effects but are also discussed to have adverse effects. Isoflavones are intensively metabolized by the gut microbiota leading to metabolites with altered estrogenic potency. The population is classified into different isoflavone metabotypes based on individual metabolite profiles. So far, this classification was based on the capacity to metabolize daidzein and did not reflect genistein metabolism. We investigated the microbial metabolite profile of isoflavones considering daidzein and genistein. Methods: Isoflavones and metabolites were quantified in the urine of postmenopausal women receiving a soy isoflavone extract for 12 weeks. Based on these data, women were clustered in different isoflavone metabotypes. Further, the estrogenic potency of these metabotypes was estimated. Results: Based on the excreted urinary amounts of isoflavones and metabolites, the metabolite profiles could be calculated, resulting in 5 metabotypes applying a hierarchical cluster analysis. The metabotypes differed in part strongly regarding their metabolite profile and their estimated estrogenic potency.
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Karki, Krishna Bahadur, Awdhesh Kumar Mishra, Seong-Jin Choi, and Kwang-Hyun Baek. "Effect of Ultraviolet C Irradiation on Isoflavone Concentrations in Different Cultivars of Soybean (Glycine max)." Plants 9, no. 8 (August 16, 2020): 1043. http://dx.doi.org/10.3390/plants9081043.

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Phytoestrogens are naturally occurring plant polyphenolic compounds present in high concentrations in soybean products. Phytoestrogens are divided into three classes: lignans, isoflavones, and coumestans. Nine types of glycoside isoflavones and three types of aglycoside isoflavones are reported in soybean. Soy isoflavones can reduce the risk of a certain type of cancer, cardiovascular problems, osteoporosis, and menopausal symptoms. We irradiated the leaves of five cultivars of soybean with UV-C (260 nm) and determined the effect on concentrations of isoflavone compounds using liquid chromatography–mass spectrometry (LC–MS). Isoflavone concentrations were significantly higher following irradiation, particularly in the cultivar Daepung, which was selected as the best cultivar for high isoflavone induction with UV-C irradiation. Further experimentation with the cultivar Daepung revealed that 20 min UV-C irradiation was the best treatment for the induction of aglycone compounds, and 5 min with the dorsal surface facing the UV-C irradiation source was the best treatment for the induction of glycoside isoflavone compounds.
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Collison, Mark W. "Determination of Total Soy Isoflavones in Dietary Supplements, Supplement Ingredients, and Soy Foods by High-Performance Liquid Chromatography with Ultraviolet Detection: Collaborative Study." Journal of AOAC INTERNATIONAL 91, no. 3 (May 1, 2008): 489–500. http://dx.doi.org/10.1093/jaoac/91.3.489.

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Abstract An interlaboratory study was conducted to evaluate a method for determining total soy isoflavones in dietary supplements, dietary supplement ingredients, and soy foods. Isoflavones were extracted using aqueous acetonitrile containing a small amount of dimethylsulfoxide (DMSO) and all 12 of the naturally occuring isoflavones in soy were determined by high-performance liquid chromatography (HPLC) with UV detection using apigenin as an internal standard. Fifteen samples (6 pairs of blind duplicates plus 3 additional samples) of soy isoflavone ingredients, soy isoflavone dietary supplements, soy flour, and soy protein products were successfully analyzed by 13 collaborating laboratories in 6 countries. For repeatability, the relative standard deviations (RSDr) ranged from 1.07 for samples containing over 400 mg/g total isoflavones to 3.31 for samples containing 0.87 mg/g total isoflavones, and for reproducibility the RSDR values ranged from 2.29 for samples containing over 400 mg/g total isoflavones to 9.36 for samples containing 0.87 mg/g total isoflavones. HorRat values ranged from 1.00 to 1.62 for all samples containing at least 0.8 mg/g total isoflavones. One sample, containing very low total isoflavones (&lt;0.05 mg/g), gave RSDR values of 175 and a HorRat value of 17.6. This sample was deemed to be below the usable range of the method. The method provides accurate and precise results for analysis of soy isoflavones in dietary supplements and soy foods.
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Ng, Ming-Sin, Yee-Shan Ku, Wai-Shing Yung, Sau-Shan Cheng, Chun-Kuen Man, Liu Yang, Shikui Song, Gyuhwa Chung, and Hon-Ming Lam. "MATE-Type Proteins Are Responsible for Isoflavone Transportation and Accumulation in Soybean Seeds." International Journal of Molecular Sciences 22, no. 21 (November 6, 2021): 12017. http://dx.doi.org/10.3390/ijms222112017.

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Soybeans are nutritionally important as human food and animal feed. Apart from the macronutrients such as proteins and oils, soybeans are also high in health-beneficial secondary metabolites and are uniquely enriched in isoflavones among food crops. Isoflavone biosynthesis has been relatively well characterized, but the mechanism of their transportation in soybean cells is largely unknown. Using the yeast model, we showed that GmMATE1 and GmMATE2 promoted the accumulation of isoflavones, mainly in the aglycone forms. Using the tobacco BrightYellow-2 (BY-2) cell model, GmMATE1 and GmMATE2 were found to be localized in the vacuolar membrane. Such subcellular localization supports the notion that GmMATE1 and GmMATE2 function by compartmentalizing isoflavones in the vacuole. Expression analyses showed that GmMATE1 was mainly expressed in the developing soybean pod. Soybean mutants defective in GmMATE1 had significantly reduced total seed isoflavone contents, whereas the overexpression of GmMATE1 in transgenic soybean promoted the accumulation of seed isoflavones. Our results showed that GmMATE1, and possibly also GmMATE2, are bona fide isoflavone transporters that promote the accumulation of isoflavones in soybean seeds.
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Vergne, Sébastien, Catherine Bennetau-Pelissero, Valérie Lamothe, Philippe Chantre, Mylène Potier, Julien Asselineau, Paul Perez, Marlène Durand, Nicholas Moore, and Patrick Sauvant. "Higher bioavailability of isoflavones after a single ingestion of a soya-based supplement than a soya-based food in young healthy males." British Journal of Nutrition 99, no. 2 (February 2008): 333–44. http://dx.doi.org/10.1017/s0007114507803953.

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Soya isoflavones, genistein and daidzein, are the focus of numerous studies investigating their potential effects on health and results remain controversial. Bioavailability is clearly a crucial factor influencing their bioefficacy and could explain these discrepancies. This study aimed at assessing: (1) the isoflavone content of sixty-nine European soya-derivative products sold on the French market; (2) the bioavailability of isoflavones comparing supplement with food. Twelve healthy volunteers were recruited in a randomized two-way crossover trial and received 35 mg isoflavones equivalent aglycone either through supplements or through cheese, both containing different patterns of isoflavone conjugates and different daidzein:genistein ratios. A specific ELISA method was used to assess the plasma and urinary concentrations of isoflavones and thus the pharmacokinetic parameters, which were then normalized to mg of each isoflavone ingested. Results showed that the normalized Cmax of daidzein (P = 0·002) and similarly the normalized AUC0 → ∞andCmaxof genistein (P = 0·002) from soya-based capsules were higher than that from soya-based cheese. In conclusion, this work completes studies on isoflavone bioavailability and presents new data regarding isoflavone concentrations in soya-derivative products. Assuming that isoflavone conjugation patterns do not influence isoflavone bioavailability, this study shows that isoflavones contained in capsules are more bioavailable than those contained in soya-based cheese. Although the supplement is more bioavailable, the relative importance of this is difficult to interpret as there is little evidence that supplements are biologically active in human subjects to date and further studies will be necessary for this specific supplement to prove its efficacy.
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Vafeiadou, Katerina, Wendy L. Hall, and Christine M. Williams. "Does genotype and equol-production status affect response to isoflavones? Data from a pan-European study on the effects of isoflavones on cardiovascular risk markers in post-menopausal women." Proceedings of the Nutrition Society 65, no. 1 (February 2006): 106–15. http://dx.doi.org/10.1079/pns2005483.

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The increase in CVD incidence following the menopause is associated with oestrogen loss. Dietary isoflavones are thought to be cardioprotective via their oestrogenic and oestrogen receptor-independent effects, but evidence to support this role is scarce. Individual variation in response to diet may be considerable and can obscure potential beneficial effects in a sample population; in particular, the response to isoflavone treatment may vary according to genotype and equol-production status. The effects of isoflavone supplementation (50 mg/d) on a range of established and novel biomarkers of CVD, including markers of lipid and glucose metabolism and inflammatory biomarkers, have been investigated in a placebo-controlled 2×8-week randomised cross-over study in 117 healthy post-menopausal women. Responsiveness to isoflavone supplementation according to (1) single nucleotide polymorphisms in a range of key CVD genes, including oestrogen receptor (ER) α and β and (2) equol-production status has been examined. Isoflavones supplementation was found to have no effect on markers of lipids and glucose metabolism. Isoflavones improve C-reactive protein concentrations but do not affect other plasma inflammatory markers. There are no differences in response to isoflavones according to equol-production status. However, differences in HDL-cholesterol and vascular cell adhesion molecule 1 response to isoflavones v. placebo are evident with specific ERβ genotypes. In conclusion, isoflavones have beneficial effects on C-reactive protein, but not other cardiovascular risk markers. However, specific ERβ gene polymorphic subgroups may benefit from isoflavone supplementation.
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Dissertations / Theses on the topic "Isoflavones"

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Bueno-Silva, Bruno 1983. "Caracterização da propolis vermelha : sua origem botanica e o efeito sazonal sobre sua composição quimica e atividade biologica." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288530.

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Orientadores: Pedro Luiz Rosalen, Severino M. Alencar
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: Entre as própolis brasileiras, urna nova própolis ainda não classificada de acordo com Park et al., 2002 e denominada de própolis vermelha originária do estado de Alagoas (Nordeste do Brasil), tem mostrado resultados interessantes em relação a sua composição química e atividade biológica em estudos preliminares. Assim, o objetivo principal deste trabalho é identificar a origem botânica da própolis vermelha, a composição química e atividade biológica do extrato etanólico da própolis (EEP) e do extrato etanólico da resina da planta (EER), avaliar o efeito sazonal sobre a composição química e atividade biológica do EEP e do EER. Esses objetivos foram atingidos através das seguintes metodologias: 1- observação do comportamento de visita das abelhas à . vegetação próxima à colméia; 2- comparação dos perfis químicos dos vegeÜlis visitados pelas abelhas coletoras de resina e da própolis vermelha, obtidos por cromatografia líquida de alta eficiência em fase reversa e análises complementares, estabelecendo-se assim, as características entre ambos os materiais, visando à identificação do marcador biológico botânico e 3- avaliação da influência do efeito sazonal anual sobre a própolis vermelha e sua vegetação fonte por meio da atividade antimicrobiana e perfil químico, com coletas bimensais das amostras durante o período de 1 ano. A atividade antimicrobiana foi avaliada por meio da Concentração Inibitória Mínima (CIM) e Concentração Bactericida Mínima (CBM) e os microrganismos usados foram: O Streptococcus mutans UA159, Streptococcus sobrinus 6715, Staphylococcus aureus ATCC25923 e Actinomyces naeslundii ATCC 12104. Os resultados demonstraram o mesmo perfil quimico entre o EEP e o EER da planta Dalbergia ecastophyllum (L.) Taub., cuja característica foi a alta concentração relativa das isoflavonas 3-hidroxi-8,9-dimetoxipterocarpin e medicarpina. Os perfis químicos do EEP e do EER, obtidos ao longo do ano, através do testes químicos, apresentaram-se distintos dos perfis dos demais 12 tipos de própolis brasileiras já classificadas e variaram quantitativamente de acordo com a sazonalidade. A CIM variou entre 15,6-125 'mu'g/rnL e a CBM de 31,2 - 500 'mu'g/mL considerando os 4 microrganismos àvaliados. Conclui-se que esta própolis, cuja origem botânica é a Dalbergia ecastophyllum, pode ser classificada corno o 13° tipo de própolis, de acordo Park et al., 2002, e tanto o EEP quanto o EER apresentaram alta atividade antimicrobiana, os quais poderão ser utilizados para pesquisas futuras de novas moléculas no controle da cárie dental
Abstract: Among the Brazilian propolis, new propolis not yet classified, according to Park et al., 2002 and called of red propolis, originary from Alagoas state (Northeast of Brazil), have showed interesting results in preliminary studies in our laboratories. Thus, the main objective of this work is to identify the botanical marker of red propolis, the chemical composition and biological activity of extract ethanolic of propolis (EEP) and the extract ethanolic of resin of plant (EER), verifying the effect of seasonal period on chemical composition and antimicrobial activity of EEP and EER. This objective was reached through the following methodologies: 1- observation of bee behavior in visiting vegetation next beehive; 2- comparison of chemical profile of vegetables visited by bees for collecting resin with red propolis, gotten for liquid chromatography of high efficiency in phase reverse and complementary analyses, for establishing the common characteristics between both materiaIs, aiming to identification of botanical biological marker; 3- evaluation of influence seasonal annual effect on the red propolis and its vegetation source by means of the antimicrobial activity and chemical profile, with bymonthly collections of the samples during the period of 1 year. The antimicrobial activity was evaluated by Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) and microorganism used were Streptococcus mutans UA159, Streptococcus sobrinus 6715, Staphylococcus aureus ATCC25923 e Actinomyces naeslundii ATCC 12104. The results had the same demonstrated to chemical profile between the EEP and the EER of the plant Dalbergia ecastophyllum (L.) Taub. Whose characteristic was the high relative concentration of isoflavonas 3-hidroxi-8,9 dimetoxipterocarpin and medicarpina. The chemical profiles of EEP and EER varied quantitatively according to seasonal effect The CIM varied between 15.6-125 'mu'g/rnL and the CBM of 31.2 - 500 'mu'g/rnL. One concludes that these propolis, whose botanical origin is the Dalbergia ecastophyllum, can be classified as 13° type of propolis, according to Park et al., 2002 and the EEP and EER showed high antibacterial activity which can be used for future molecule research in the control of caries dental
Mestrado
Farmacologia, Anestesiologia e Terapeutica
Mestre em Odontologia
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Cardoso, Julio Roquete. "Efeitos da exposição a isoflavonas da soja sobre a saude reprodutiva de coelhos machos." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/318000.

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Orientador: Sonia Nair Bao
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: Este estudo foi proposto para avaliar se a exposição perinatal (gestacional e lactacional) ou crônica a isoflavonas em dieta contendo soja ou na forma de concentrados de isoflavonas pode comprometer a saúde reprodutiva de coelhos machos. No primeiro experimento, fêmeas foram alimentadas com dieta contendo soja ou dieta isenta de soja e alfafa, suplementada com 10 ou 20 mg/kg/dia de isoflavonas ao longo da gestação e lactação. O grupo controle foi mantido somente com a dieta isenta de soja e alfafa. Na desmama, foram avaliados o peso e a morfologia dos órgãos do aparelho reprodutor e os níveis séricos de testosterona de parte dos filhotes machos. O restante deles foi submetido à dieta controle desde a desmama até a fase adulta. Após a puberdade, os animais foram avaliados quanto ao comportamento sexual, qualidade do sêmen e morfologia dos órgãos reprodutivos. No segundo experimento, fêmeas foram alimentadas com as mesmas dietas empregadas no primeiro experimento, porém a suplementação com isoflavonas foi realizada com doses variando de 2,5 a 20 mg/kg/dia. As doses de isoflavonas foram selecionadas com base em estimativas da ingestão de isoflavonas a partir do consumo de alimentos derivados da soja. Após a desmama, os filhotes machos receberam a mesma dieta fornecida para suas respectivas mães até o fim do experimento. Foi avaliado nestes animais a idade à puberdade, qualidade do sêmen e o comportamento sexual, e, na 33ª semana de vida o peso e a morfologia dos órgãos reprodutivos. Os resultados deste estudo foram baseados em dados obtidos da avaliação de 100 machos num período de 3 anos. O número de espermatozóides esteve de acordo com os valores da literatura para coelhos da raça Nova Zelândia e não variou significativamente em relação ao grupo controle, embora o volume de sêmen tenha sido menor em coelhos expostos à alta dose de isoflavonas (20 mg/kg/dia). O peso dos órgãos reprodutivos não diferiu estatisticamente do grupo controle e não houve evidência de malformações genitais, alterações metaplásicas, ou qualquer outra alteração histopatológica correlacionada com os tratamentos. Nos jovens, a análise histológica dos testículos não revelou diferenças no desenvolvimento gonadal. Coelhos suplementados de forma crônica com 20 mg/kg/dia de isoflavonas apresentaram menor ingestão de alimentos e peso corporal na fase adulta. Este achado é economicamente importante na produção animal; todavia os animais alimentados com a dieta contendo soja apresentaram na 33ª semana de idade consumo de alimento e peso corporal maiores em 6 e 4% respectivamente do que os animais do grupo controle (P < 0,05). Apesar dos recentes alertas, os resultados deste estudo não suportam a hipótese de que a exposição à isoflavonas em doses compatíveis com o consumo de alimentos à base de soja possa comprometer a saúde reprodutiva masculina
Abstract: This study was proposed to determine if perinatal (that is gestation and lactation) or chronic exposure to isoflavones trough consumption of soy containing diet or semipurified soy isoflavones may disrupt male reproductive health of rabbits. In the first experiment, groups of dams were fed either soy containing diet or soy and alfafa free diet supplemented with soy isoflavones at levels of 10 and 20 mg/kg/day throughout gestation and lactation. The control group was kept on soy and alfafa free diet only. Reproductive organs weight and morphology and serum levels of testosterone of part of the male offspring were evaluated at weaning. Remaining males were subjected to the control diet from weaning to adulthood. Sexual behavior, semen quality and reproductive organs morphology were evaluated after puberty. In the second experiment, groups of dams were fed same diets employed in the experiment 1, but supplementation with isoflavones were performed with doses ranging from 2,5 to 20 mg/kg/day. Dose levels of isoflavones were selected on the basis of the reported estimative of isoflavones intake from the consumption of soy-based foods. After weaning, male offspring received the same diet, which was given to the respective mother. The age that males reached puberty, semen quality and sexual behavior were evaluated in these animals and at 33 weeks of age reproductive organs weight and morphology were analyzed. Results of this study were sustained by data from the evaluation of 100 males in a period of 3 years. Sperm counts was within literature values for New Zealand rabbits and did not vary significantly in relation to control group, although semen volume has been lesser in rabbits exposed to high levels of isoflavones (20 mg/kg/dia). Reproductive organs weight did not differ statistically from the control, and there was no gross evidence of genital malformations, metaplastic changes, or any histopathologic alteration that was correlated with the treatments. In the young rabbits, histological analysis of the testes did not revel differences in gonadal development. Rabbits chronically supplemented with 20 mg/kg/day of soy isoflavones showed lesser food intake and body weight at adulthood. This find is economically important in animal production; however the animals fed soy containing diet showed food consumption and body weight 6 and 4%, respectively higher than animals of the control group at 33 weeks of age (P <0.05). In conclusion, despite recent alerts, results of this study did not support the hypothesis that isoflavones consumption at dietary levels may impair male reproductive health
Doutorado
Biologia Celular
Doutor em Biologia Celular e Estrutural
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3

Tan, Jingjun. "Dietary isoflavones : aglycones and glycosides." Thesis, University of Leeds, 2011. http://etheses.whiterose.ac.uk/2092/.

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Flavonoids are non-nutrient secondary metabolites ubiquitous in plants, associated with protection against various diseases, such as cancer and cardiovascular diseases. Dietary flavonoids are normally found as conjugated glycosides except, notably, in fermented foods where although there may be losses in total flavonoid content, levels of liberated aglycones can be relatively high. There has been considerable interest in the relationship between the form and structure of the ingested flavonoids and the consequences for efficiency of absorption. The research focused firstly on β-D-glucosidases (β-D-glycoside glucohydrolase, EC 3.2.1.21) extracted from different plant sources and characterised. The enzyme was found at the highest levels in almond and apple seeds. The optimum reaction conditions of the enzyme from apple seeds were determined to be pH 5.5 at 65ºC, and the enzyme extract was stable at 4ºC for at least 12 weeks. Kinetic characterisation of the enzyme from selected materials was carried out by using para-nitrophenyl-β-D-glucopyranoside (p-NP-Glc) as substrate. The Km and Vmax of the enzyme from apple seed extract were determined, for the first time, to be 5.48 ± 0.34 mM and 15.60 ± 0.95 U/mg protein (n = 8), respectively, with the protein content of the extract being 0.728 ± 0.019 mg/ml. Secondly, isoflavone contents from different sources were investigated. Soy bean and its products are were found to be good sources of daidzin and genistin; kudzu was the best source of puerarin; red clover and chickpea were good sources of formononetin and biochanin A. Passion fruit was found to be an interesting source of isoflavones outside the legume family. By using selected enzyme sources and isoflavone sources, a novel natural style soy-based food was developed in which isoflavones existed predominately as aglycones. The food, derived using soya and enzymes from waste sources, may have further potential.
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Artigot, Marie-Pierre. "Etude du déterminisme génétique des différences de teneurs et de profils en isoflavones dans la graine de soja (Glycine max L. Merrill)." Thesis, Toulouse, INPT, 2012. http://www.theses.fr/2012INPT0065/document.

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La graine de soja contient de grandes quantités d'isoflavones (génistéine, daidzéine et glycitéine). En raison de leurs propriétés phytoestrogéniques, ces composés peuvent avoir des effets bénéfiques sur la santé humaine, mais ils peuvent aussi être perçus comme perturbateurs endocriniens, en particulier dans les laits pour nourrissons. La teneur et la composition en isoflavones de la graine diffèrent selon la fraction considérée. Les cotylédons contiennent de la génistéine et de la daidzéine, tandis que les germes, avec une teneur quatre à dix fois supérieure, contiennent majoritairement de la daidzéine et de la glycitéine. Le génotype influence fortement la teneur en isoflavones totales. Le déterminisme du pourcentage des isoflavones est essentiellement génétique. Ce travail porte sur l'étude du déterminisme génétique à l'origine des variations de teneurs et de compositions en isoflavones dans les germes et les cotylédons de la graine, en tenant compte également du net décalage de l'accumulation entre ces deux compartiments, au cours du développement de la graine. Dans un premier temps, les gènes des isoflavone synthases (IFS) de variétés très différenciées pour leurs teneurs et profils d'isoflavones ont été séquencés, puis les expressions des gènes clefs de la biosynthèse (neuf chalcone synthases (CHS), une chalcone réductase (CHR), quatre chalcone isomérases (CHI) et les deux isoflavone synthases (IFS) ont été suivies par RT-PCR quantitative dans les cotylédons et dans les germes, à trois stades critiques du développement de la graine (25, 40 et 60 jours après floraison). La seconde partie de ce travail a été consacrée à l'étude de l'expression de différents gènes candidats de la flavonoïde 6-hydroxylase (F6H) catalysant la première étape de la synthèse de la glycitéine. Le polymorphisme des séquences génomiques IFS1 et IFS2 des isoflavone synthases n'a pas montré de lien avec les différences de teneurs en isoflavones entre les variétés. L'activité transcriptionnelle des gènes de biosynthèse des isoflavones souligne l'existence d'une régulation bien distincte de cette synthèse dans ces deux compartiments. Les taux d'expression des gènes cibles ne sont pas toujours reliés avec les différences de teneurs ou de profils dans les germes et les cotylédons, suggérant ainsi l'effet prépondérant des régulations post-traductionnelles, notamment dans la formation du complexe multienzymatique de biosynthèse de ces composés. Nous avons aussi mis en évidence une forte expression du gène CHS9 codant pour la chalcone synthase 9, avec un profil correspondant plus à l'accumulation des isoflavones dans le germe que dans les cotylédons. Les gènes CHS7 et CHS8 codant pour les chalcone synthases 7 et 8, déjà signalés comme fortement corrélés à la synthèse des isoflavones, sont plus liés à l'accumulation dans les cotylédons que dans les germes. Ces travaux montrent aussi que le gène F6H signalé dans la littérature ne s'exprime pas dans les germes. En revanche, deux candidats dont la séquence est similaire à 79% ont été étudiés. Le gène F6H3 est le seul à s'exprimer dans la graine, uniquement dans le germe. Son expression n'a pas été détectée dans les germes d'une lignée mutante qui ne produit pas de glycitéine. Ce gène est donc un candidat potentiel clef pour la synthèse de la glycitéine dans le germe. La structure particulière de l'enzyme correspondante pourrait indiquer une forte implication de l'architecture du complexe enzymatique et des contraintes qui en découlent dans l'utilisation préférentielle d'une voie ou d'une autre dans ce schéma de biosynthèse
The soybean seed contains large amounts of isoflavones (genistein, daidzein, and glycitein). Owing to their phytoestrogenic properties, these compounds can have beneficial effects on human health, but they can also be considered as endocrine disruptors, for example in infant formulas. The isoflavone content and composition in the seed depend on the considered fraction. The cotyledons contain only genistein and daidzein, while the hypocotyls are four to ten times more concentrated and contain three isoflavones, mostly daidzein and glycitein. The genotype has a strong influence on total isoflavone content, and even more on the percentage of individual isoflavones in cotyledons and hypocotyls. The objective of this work is to investigate the genetic determinism that underlies such contrasted contents and compositions between the two seed fractions, and the relation between main biosynthetic steps and genotypic differences. First, the genes of isoflavone synthases (IFS) were sequenced in varieties with highly contrasted content and composition. The expression of different keys genes of the biosynthesis (nine chalcone synthases (CHS), a chalcone reductase (CHR), four chalcone isomerases (CHI) and the two isoflavone synthases (IFS) have then been followed by quantitative RT - PCR in the cotyledons and hypocotyls, at three critical stages of seed development (25, 40 and 60 days after flowering). Second, the expression of different candidate genes for the flavonoid 6-hydroxylase (F6H) which catalyzes the first step in the synthesis of the glycitein has been investigated. The polymorphism of the genomic sequences IFS1 and IFS2 of isoflavone synthases was not correlated with differences in isoflavone contents. The transcriptional activity of key genes of the biosynthesis of isoflavones pointed out the existence of a distinct regulation of isoflavone biosynthesis between the two seed fractions. The expression levels of target genes were not always related to differences in isoflavone content or compositions in the hypocotyls and cotyledons. This suggests the overriding effect of post-translational regulation, especially in the formation of multienzyme complex of biosynthesis of these compounds. The chalcone synthase gene CHS9 was highly expressed, with a profile similar to the accumulation of isoflavones in hypocotyls. The chalcone synthase genes CHS7 and CHS8 expressions, already reported as highly correlated to the biosynthesis of isoflavones were more related to accumulation in the cotyledons than in hypocotyls. This work has also shown that the F6H gene, reported in the literature was not expressed in the hypocotyls. However, two candidates with as highly similar coding sequence (79%) have been studied. The F6H3 gene is the only one expressed in the seed, more precisely in the hypocotyls but it was not expressed in the cotyledons. Moreover, it was not expressed in a mutant line which did not accumulate glycitein. This gene is therefore a key potential candidate for the synthesis of the glycitein in hypocotyls. The particular structure of the corresponding enzyme may indicate a strong involvement of the architecture of the multienzyme complex of isoflavones biosynthesis and the constraints arising in the preferential use of a track or another in this scheme of biosynthesis
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Pritchett, Louise Emma. "Metabolism and intestinal transport of isoflavones." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423998.

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6

Queirós, Lívia Dias 1988. "Biotransformação de compostos fenólicos do extrato de soja para obtenção de produto rico em compostos bioativos." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256640.

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Orientador: Gabriela Alves Macedo
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
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Resumo: A soja atrai considerável atenção no atual cenário econômico mundial devido ao seu elevado potencial nutritivo e efeitos potencialmente benéficos à saúde humana, que são atribuídos principalmente às isoflavonas. Esta classe de fenóis heterocíclicos é conhecida por suas atividades biológicas, tais como as atividades estrogênica, antioxidante e antitumoral, sendo as formas agliconas mais ativas do que as glicosiladas. Contudo, estudos têm mostrado que a eficácia clínica das isoflavonas está relacionada com a capacidade de produção de equol, um metabólito da daidzeína que, segundo a literatura vigente, é produzido exclusivamente pela ação da microbiota intestinal. Assim, há evidências de que nem todos os indivíduos são capazes de metabolizar as isoflavonas a equol, sendo essa variabilidade atribuída às diferenças na composição da microflora intestinal, hábitos alimentares, fatores genéticos, dentre outros. Neste contexto, os produtos à base de soja são uma forma de incluir as isoflavonas na dieta, sendo que o extrato hidrossolúvel de soja (EHS) é um substrato que tem se apresentado com potencial para produção de novos alimentos com apelo saudável. Desse modo, com o propósito de aumentar o conteúdo de isoflavonas bioativas e avaliar a viabilidade de um processo biotecnológico para produção de equol in vitro, neste projeto foi investigada a aplicação de culturas starters e bactérias lácticas probióticas na fermentação do EHS, aliado à ação do extrato bruto de tanase obtido a partir de Paecilomyces variotti. Além disso, também foi avaliada a biotransformação dos compostos fenólicos e atividade antioxidante do produto obtido. O teor de fenóis totais foi avaliado pelo método de Folin-Ciocalteau, a atividade antioxidante pelos métodos in vitro ORAC e de sequestro de radicais DPPH e o perfil químico dos extratos, antes e depois dos processos de biotransformação, foi avaliado por CLAE-DAD com co-injeção de padrões de isoflavonas. Após o processo fermentativo e/ou tratamento enzimático do EHS, houve um significativo aumento no teor de fenólicos totais e capacidade antioxidante, evidenciada por ambos métodos empregados (ORAC e DPPH), quando comparados com o controle do EHS sem reação. Além disso, foi verificada uma modificação no perfil polifenólico das amostras do EHS biotransformadas evidenciado por CLAE-DAD, resultando em um aumento na concentração das formas agliconas em relação às glicosiladas, bem como o aumento da concentração de equol após os processos de biotransformação propostos. Os resultados obtidos por CLAE-DAD confirmaram que o extrato de tanase de P. variotty foi capaz de biotransformar as formas glicosiladas (daidzina e genistina) das isoflavonas em suas respectivas formas agliconas (daidzeína e genisteína), indicando uma atividade diglicosídica do extrato semipurificado de tanase. Pelo que se tem conhecimento, a hidrólise de isoflavonoides glicosilados por tanase, bem como a formação de equol, é um relato inédito na literatura demonstrando que é possível desenvolver um processo in vitro para a obtenção deste composto bioativo, sem a presença de bactérias intestinais, utilizando apenas uma biotransformação enzimática
Abstract: The soy attracts considerable attention in the current global economic scenario due to their high nutritional potential and potentially beneficial effects to human health, which are mainly attributed to isoflavones. This class of heterocyclic phenols is known for its biological activities, such as estrogenic, antioxidant and antitumor activities, and the aglycone forms are more active than the glycosylated. However, studies have shown that the clinical efficacy of isoflavones is related to the capacity to produce equol, a metabolite of daidzein, which according to the current literature it is produced exclusively by the action of the gut microbiota. Thus, there is evidence that not all individuals are able to metabolize isoflavones to equol and this variability is attributed to differences in the composition of gut microflora, diet, genetic factors, among others. In this context, the soy-based products are a way to include the isoflavones in the diet, and the soymilk is a substrate that has shown the potential to produce new foodstuff with healthy appeal. Thus, in order to increase the content of bioactive isoflavones and assess the viability of a biotechnological process for in vitro production of equol, in this project was investigated the application of starters and probiotic lactic bacteria strains in the fermentation of soymilk, combined with the action of the crude extract of tannase obtained from Paecilomyces variotii. Furthermore, it was also evaluated the biotransformation of phenolic compounds and antioxidant activity of the obtained product. The total phenolic content was assessed by Folin-Ciocalteau method, the antioxidant activity by in vitro methods of ORAC and DPPH radical sequestration and the chemical profile of the extracts, before and after the processes of biotransformation, was evaluated by HPLC-DAD with co- injection of standards of isoflavones. After the fermentation process and/or enzymatic treatment of the soymilk, there was a significant increase of the total phenolic content and antioxidant capacity, as evidenced by both methods employed (ORAC and DPPH), compared with the standard soymilk. Furthermore, there was observed a change in the polyphenolic profile of biotransformed samples of soymilk, evidenced by HPLC-DAD, resulting in an increase in the concentration of the aglycones in relation to glucosides forms, as well as there was a significant increase of the concentration of equol after the biotransformation processes proposed. The results obtained by HPLC-DAD confirmed that the extract of tannase from P. variotii was able to biotransform the glucosides forms (daidzin and genistin) of isoflavones in their aglycone forms (daidzein and genistein), indicating a diglycosidase activity of the crude extract of tannase. From what is known, the hydrolysis of glucosides isoflavone by tannase, as well as the formation of equol, is an unpublished report in the literature demonstrating that it is possible to develop an in vitro method for obtaining this bioactive compound, without the presence of gut bacteria process using only an enzymatic biotransformation
Mestrado
Ciência de Alimentos
Mestra em Ciência de Alimentos
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7

Dettenborn, Greice Raquel. "Investigação de isoflavonas em espécies de leguminosas nativas do sul do Brasil, com ênfase em trifolium riograndense Burkart." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/28520.

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Isoflavonas são compostos fenólicos de ocorrência principalmente na família Leguminosae, utilizados, entre outros, como alternativa para a reposição hormonal em mulheres no período pós-menopausa, devido a sua ação estrogênica seletiva. Em vista disso, foi investigada a presença das isoflavonas daidzeína, genisteína, formononetina e biochanina A em 153 espécies de Leguminosas nativas do Rio Grande do Sul através de cromatografia líquida de alta eficiência. Destas, 42 espécies apresentaram ao menos uma das quatro isoflavonas investigadas. Pertencente à família Leguminosae, o gênero Trifolium é encontrado em quase toda a zona temperada e subtropical do mundo, sendo que a espécie Trifolium riograndense é nativa do estado do Rio Grande do Sul. As isoflavonas daidzeína, genisteína, formononetina e biochanina A foram quantificadas nesta espécie, que apresentou 0,187 mg de daidzeína; 0,223 mg de genisteína; 16,683 mg de formononetina e 1,207 mg de biochanina A (por grama de amostra seca). A parte da planta com maior concentração de isoflavonas foi a folha, com 7,331 mg por grama de amostra seca, e a parte da planta com menor teor destas isoflavonas foi a raiz, com 2,806 mg por grama de amostra seca. Formononetina foi a isoflavona majoritária em todas as partes da planta analisadas. Ainda, foram realizados ensaios de atividade antiinflamatória do extrato das folhas de Trifolium riograndense. Foram utilizados os modelos de quimiotaxia in vitro em câmara de Boyden e indução de edema em pata de ratos, utilizando a carragenina como agente flogístico. Pelo ensaio de quimiotaxia, verificou-se que o extrato das folhas do trevo em estudo apresentou inibição da migração leucocitária de forma significativa em diversas concentrações testadas. Através do ensaio de edema em pata de rato, verificou-se que a administração por via oral de extrato de Trifolium riograndense em ratos, na dose de 100 mg/kg, inibiu a formação do edema provocado pela carragenina, significativamente.
Isoflavones are polyphenolic compounds of Leguminosae Family. They are used as alternative therapy for treating symptoms of the menopause, due their selective action in oestrogenic receptors. So, the presence of isoflavones daidzein, genistein, formononetin and biochanin A was investigated in 153 species of the Leguminosae Family that are natives of South Brazil, by high performance liquid chromatography. Forty two species showed at least one of four investigated isoflavones. The genus Trifolium belongs to Leguminosae Family. It is found in temperate and subtropical regions in the world. Trifolium riograndense is a species native of Rio Grande do Sul – Brazil. The isoflavone content in this species was 0.187 mg g-1 of dry material (DM) to daidzein; 0.223 mg g-1 of DM to genistein; 16.683 mg g-1 of DM to formononetin, and 1.207 mg g-1 of DM to biochanin A. The leaf was the part of the plant with more isoflavone content, 7.331 mg of DM. The root was the part with less isoflavone content, 2.806 mg of DM. The majority isoflavone in all parts was formononetin. The dry extract of leaves of Trifolium riograndense was submitted to biological tests. The anti-inflammatory activity was analyzed by Boyden chamber assay, it allowed observe chemotaxis phenomenon, and by induced rat paw oedema using carrageenan as flogistic agent. Through chemotaxis model, potential activity could be observed to extract of Trifolium riograndense. In the induced rat paw oedema test, a significantly inhibition of oedema was observed in the animals treated with extract of Trifolium riograndense (100 mg/kg).
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Yeh, Linda Minlin. "Assessment of urinary isoflavones among premenopausal women." Thesis, University of Hawaii at Manoa, 2003. http://hdl.handle.net/10125/7053.

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Epidemiological and clinical studies researching the effects of soy food intake require a high compliance to a soy diet protocol. Measuring isoflavones in the bodily fluids is the most objective method in determining dietary compliance because isoflavones are highly and positively correlated with soy food intake and specific to soy foods. Urine analysis is preferred over plasma due to its noninvasiveness, which aids in compliance. Our study investigated the accuracy of collecting weekly and single day samples from 19 premenopausal women on a daily soy diet protocol in comparison to monthly samples for determining dietary compliance. We compared urinary isoflavone excretion rates (UIER) of weekly samples and single day samples to the UIER of a monthly sample that consisted of urine collected daily. Correlations were high between all samples and the monthly UIER. The correlations of the mean of all weeks UIER and single day UIER with the monthly UIER were 0.96 and 0.89, respectively. No large differences were seen when samples were stratified by ethnicity, 8MI, and equol excretor status. The small degree of increased accuracy in determining dietary compliance in measuring monthly UIER compared to weekly does not justify the extra time and effort required by the subjects and staff. Therefore, we conclude that analyzing weekly UIER is an accurate and feasible method of determining dietary compliance with a soy-based diet
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9

Duffy, Rosanna Mary. "Health benefits and metabolism of soya isoflavones." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407466.

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10

Ručková, Michaela. "Komplexní studium biologických účinků vybraných typů sojových výrobků." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2020. http://www.nusl.cz/ntk/nusl-433493.

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Soybeans and products thereof are considered as a very contradictory legume across layman and expert opinions. Some see it almost as a “superfood” while others avoid it due to its biologically active content with an unclear effect on the organism. As a lot of research on soybeans was already performed the content varies considerably and it is not easy to grasp the issue correctly. The objective of the research part of the thesis is a structuralized study of already published scientific knowledge to clarify the current state of the art. Experimental part of the thesis focuses on characterisation of soy and its products in terms of active ingredients content and determination of antioxidants and antimicrobial effect. After that, the cytotoxic effect on human heterogeneous colorectal adenocarcinoma epithelial cell line and mouse melanoma cell line is determined by in vitro testing. All obtained information and results of experimental part could possibly serve as a starting point for further study of soy and soy products, both in the dissertation and in the submission of a grant project.
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Books on the topic "Isoflavones"

1

Preedy, Victor R., ed. Isoflavones. Cambridge: Royal Society of Chemistry, 2012. http://dx.doi.org/10.1039/9781849735094.

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Preedy, Victor R. Isoflavones: Chemistry, analysis, function, and effects. Cambridge, UK: RSC Pub., 2013.

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Bennetau-Pelissero, Catherine. Isoflavones: A race after the rescue of the ageing hippocampus. Hauppauge, N.Y: Nova Science Publishers, 2011.

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Kim, Hŭi-sŏn. Noe sogyo sepʻo esŏ isoflavones ŭi hangyŏmchŭng chagyong kijŏn kyumyŏng mit noe chirhwan chʻiryo e ŭngyong =: Identification of anti-inflammatory mechanism of isoflavones in brain microglia and application to treatment of neurodegenerative diseases. [Seoul]: Pogŏn Pokchibu, 2007.

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International, Symposium on the Role of Soy in Preventing and Treating Chronic Disease (2nd 1996 Brussels Belgium). The role of soy in preventing and treating chronic disease: Proceedings of a symposium held on September 15-18, 1996, the Second International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, and a satellite symposium held on September 19, 1996, in Brussels, Belgium. [Bethesda, MD: American Society for Clinical Nutrition], 1998.

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International Symposium on the Role of Soy in Preventing and Treating Chronic Disease (2nd 1996 Brussels, Belgium). The role of soy in preventing and treating chronic disease. Edited by Messina Mark and Erdman John W. [Bethesda, MD: American Institute of Nutrition], 1998.

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Breitman, Pearl Laurie. Effects of isoflavone and calcium supplementation on bone metabolism in ovariectomized rats. Ottawa: National Library of Canada, 2002.

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Elkins, Rita. Genistein/Soy Isoflavones: Potent Soy Isoflavone (Woodland Health). Woodland Publishing, 1998.

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Preedy, Victor R., K. Nara, P. Kachlicki, J. Malysz, and R. Baber. Isoflavones: Chemistry, Analysis, Function and Effects. Royal Society of Chemistry, The, 2012.

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Isoflavones: Biosynthesis, Occurrence and Health Effects. Nova Science Pub Inc, 2010.

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Book chapters on the topic "Isoflavones"

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Vanden Berghe, Wim, Nathalie Dijsselbloem, and Guy Haegeman. "Isoflavones." In Encyclopedia of Cancer, 1–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_3157-2.

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Berghe, Wim Vanden, Nathalie Dijsselbloem, and Guy Haegeman. "Isoflavones." In Encyclopedia of Cancer, 2363–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-46875-3_3157.

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Vanden Vanden Berghe, Wim, Guy Haegeman, and Nathalie Dijsselbloem. "Isoflavones." In Encyclopedia of Cancer, 1918–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_3157.

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Křížová, Ludmila, Kateřina Dadáková, and Veronika Farková. "Isoflavones." In Handbook of Food Bioactive Ingredients, 1–27. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-81404-5_8-1.

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Křížová, Ludmila, Kateřina Dadáková, and Veronika Farková. "Isoflavones." In Handbook of Food Bioactive Ingredients, 313–39. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-28109-9_8.

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Campos, Maria Graça. "Soy Isoflavones." In Handbook of Dietary Phytochemicals, 1–38. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-13-1745-3_8-1.

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Campos, Maria Graça. "Soy Isoflavones." In Handbook of Dietary Phytochemicals, 205–42. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-4148-3_8.

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Fleury, Y., D. H. Welti, G. Philippossian, and D. Magnolato. "Soybean (Malonyl) Isoflavones." In ACS Symposium Series, 98–113. Washington, DC: American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0507.ch008.

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Clair, R. St, and M. Anthony. "Soy, Isoflavones and Atherosclerosis." In Atherosclerosis: Diet and Drugs, 301–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/3-540-27661-0_10.

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Atcharaporn, Khoomtong, Pananun Thawunporn, and Buddhi Lamsal. "Isoflavones - Extraction and Bioavailability." In Functional Foods and Dietary Supplements, 255–93. Chichester, UK: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118227800.ch10.

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Conference papers on the topic "Isoflavones"

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Muntean, Edward, and Camelia Urda. "Isoflavones in red clover tea infusions." In 6th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07251.

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"Antioxidant Activity of Isoflavones from Tofu Pulp Waste." In 6th International Conference on Advances in Engineering Sciences and Applied Mathematics. International Institute of Engineers, 2016. http://dx.doi.org/10.15242/iie.a1216006.

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Marik, Radharani, Saraswati Sukumar, Martha Zeiger, Vered Stearns, and Christopher Umbricht. "Abstract A50: Soy isoflavones and vitamin D in breast cancer prevention." In Abstracts: Frontiers in Cancer Prevention Research 2008. American Association for Cancer Research, 2008. http://dx.doi.org/10.1158/1940-6207.prev-08-a50.

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Martinez-Montemayor, Michelle M., Elisa Otero-Franqui, Luis A. Cubano, and Suranganie Dharmawardhane Flanagan. "Abstract 5725: Differential effects of dietary soy isoflavones on cancer metastasis." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-5725.

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Davis, B. E., M. D. Flythe, T. A. Hamilton, D. G. Ely, L. H. Anderson, and J. R. Weinert-Nelson. "Isoflavones in Legumes as Functional Forages and Feeds in Ruminant Grazing Systems." In XXV International Grassland Congress. Berea, KY 40403: International Grassland Congress 2023, 2023. http://dx.doi.org/10.52202/071171-0265.

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Sae-Foo, W., N. Nualkaew, G. Yusakul, and W. Putalun. "Estrogenic activity of isoflavones derived from Derris scandens using MCF-7 cell." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759102.

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Wongrungrote, Phanarat, Sunisa Thaichinda, and Phakkharawat Sittiprapaporn. "Beneficial effect of isoflavones to post-menopausal women with insomnia: A preliminary study." In 2018 International Conference on Digital Arts, Media and Technology (ICDAMT). IEEE, 2018. http://dx.doi.org/10.1109/icdamt.2018.8376548.

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Oliveira, Jordana M., Gustavo M. Faria, Tulio R. Pimenta, Cesar A. S. T. Vilanova Costa, and Antonio M. T. C. Silva. "THE RELATIONSHIP BETWEEN THE CONSUPTION OF ISOFLAVONES AND THE DEVELOPMENT OF BREAST CANCER." In Brazilian Breast Cancer Symposium. v29s1, 2019. http://dx.doi.org/10.29289/259453942019v29s1ep58.

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Zong, Wei, and Hanjun Ma. "Adsorption of Soybean Isoflavones from Soybean Whey Wastewater with Magnetic AB-8 Resin." In 2008 2nd International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2008. http://dx.doi.org/10.1109/icbbe.2008.1016.

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Sekine, Ryo, Naomi Lewcenko, Evan Robertson, Leone Spiccia, Don McNaughton, P. M. Champion, and L. D. Ziegler. "Surface-Enhanced Raman Spectroscopy Of Isoflavones With Silver-Doped Nano-Porous Inorganic Substrates." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482312.

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Reports on the topic "Isoflavones"

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Sarkar, Fazlol. Soy Metabolites, Isoflavones in Cell Growth and Apoptosis. Fort Belvoir, VA: Defense Technical Information Center, January 2002. http://dx.doi.org/10.21236/ada405198.

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Sarkar, Fazlul. Soy Metabolites, Isoflavones in Cell Growth and Apoptosis. Fort Belvoir, VA: Defense Technical Information Center, August 1999. http://dx.doi.org/10.21236/ada374128.

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Kucuk, Omer. Modulation of Growth and Differential in Breast Cancer by Soy Isoflavones. Fort Belvoir, VA: Defense Technical Information Center, November 2000. http://dx.doi.org/10.21236/ada393883.

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Kucuk, Omer. Modulation of Growth and Differentiation in Breast Cancer by Soy Isoflavones. Fort Belvoir, VA: Defense Technical Information Center, November 2002. http://dx.doi.org/10.21236/ada413354.

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Kucuk, Omer. Modulation of Growth and Differentiation in Breast Cancer by Soy Isoflavones. Fort Belvoir, VA: Defense Technical Information Center, November 1999. http://dx.doi.org/10.21236/ada391628.

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Abu-Jaradeh, Rula Ahmed-Eid. The effect of dietary supplementation on immune function Two specific immuno-nutrients: Glutamine and Isoflavones. Ames (Iowa): Iowa State University, January 2002. http://dx.doi.org/10.31274/cc-20240624-1423.

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de la Parra Simental, Columba. Role of Protein Synthesis Initiation Factors in Dietary Soy Isoflavone-Mediated Effects on Breast Cancer Progression. Fort Belvoir, VA: Defense Technical Information Center, August 2014. http://dx.doi.org/10.21236/ada610997.

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Chalutz, Edo, Charles Wilson, Samir Droby, Victor Gaba, Clauzell Stevens, Robert Fluhr, and Y. Lu. Induction of Resistance to Postharvest Diseases and Extension of Shelf-Life of Fruits and Vegetables by Ultra-Violet Light. United States Department of Agriculture, February 1994. http://dx.doi.org/10.32747/1994.7568093.bard.

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Abstract:
Following preliminary observations by one of the collaborating scientists on this project and the completion of a 1-year, BARD-supported feasibility study (IS-1908-90F), this 3-year BARD project has been executed. The main objectives of the research were to elucidate biochemical and pathological aspects of UV-induced resistance in fruits and vegetables, to characterize physical and biological variables of induced resistance and delay of ripening, and to explore the application of the treatment as a control practice of postharvest diseases and shelf-life extension of fruits and vegetables. Our findings, which are detailed in numerous joint publications, have shown that the effect of UV-C light on induction of resistance and delay of ripening is a general one and of wide oddurrence. Apart from surface sterilization of the commodity, the reduction of decay of different fungi has been associated with and induced resistance phenomenon which gradually builds up within 24 to 48 hours after the UV treatment and can be reversed by visible light. In citrus, induced resistance has been associated with increased activity of the enzymes phenylalanine ammonia-lyase and peroxidase, and with the levels of endglucanase and chitinase. In tomato, resistance was correlated with the production of high levels of tomatine. Our study of some molecular aspects of the induced resistance in grapefruit has revealed the induction of a cDNA which represents a gene encoding for an isoflavone reductase-like protein that, in legumes, has been associated with phytoalexin biosynthesis. This gene was cloned and sequenced. Delay of ripening was associated in tomato with inhibition of ethylene production, carotenoid synthesis, and chlorophyll degradation and with the presence of high levels of polyamines. In peach fruit epiphytic populations of a yeast increased following the UV treatment. Pilot-size treatment and packing lines were constructed in the US and Israel to test the application of the UV treatment on a semi-commercial scale. Although effective in reduction of decay and delay of ripening, a number of problems will have to be addressed before practical application of this methodology can be realized. The main issues are associated with the temporal and variable response to the treatment, and its relationship to the maturity and date of harvest of the commodity.
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