Journal articles: 'Isoferulic acid'

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Hodgson, Jonathan M., Shin Yee Chan, Ian B. Puddey, Amanda Devine, Naiyana Wattanapenpaiboon, Mark L. Wahlqvist, Widjaja Lukito, et al. "Phenolic acid metabolites as biomarkers for tea- and coffee-derived polyphenol exposure in human subjects." British Journal of Nutrition 91, no. 2 (February 2004): 301–5. http://dx.doi.org/10.1079/bjn20031046.

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Tea and coffee are rich in polyphenols with a variety of biological activities. Many of the demonstrated activities are consistent with favourable effects on the risk of chronic diseases. 4-O-methylgallic acid (4OMGA) and isoferulic acid are potential biomarkers of exposure to polyphenols derived from tea and coffee respectively. 4OMGA is derived from gallic acid in tea, and isoferulic acid is derived from chlorogenic acid in coffee. Our major objective was to explore the relationships of tea and coffee intake with 24 h urinary excretion of 4OMGA and isoferulic acid in human subjects. The relationships of long-term usual (111 participants) and contemporaneously recorded current (344 participants) tea and coffee intake with 24 h urinary excretion of 4OMGA and isoferulic acid were assessed in two populations. 4OMGA was related to usual (r 0·50, P<0·001) and current (r 0·57, P<0·001) tea intake, and isoferulic acid was related to usual (r 0·26, P=0·008) and current (r 0·18, P<0·001) coffee intake. Overall, our present results are consistent with the proposal that 4OMGA is a good biomarker for black tea-derived polyphenol exposure, but isoferulic acid may be of limited usefulness as a biomarker for coffee-derived polyphenol exposure.

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Karamać, M., A. Buciński, B. Pegg R, and R. Amarowicz. "Antioxidant and antiradical activity of ferulates." Czech Journal of Food Sciences 23, No. 2 (November 15, 2011): 64–68. http://dx.doi.org/10.17221/3373-cjfs.

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Antioxidant and antiradical activities of ferulates (i.e., ferulic acid, isoferulic acid, coniferyl aldehyde, and methyl ferulate) were investigated using a β-carotene-linoleate model system and a DPPH radical scavenging assay, respectively. Compounds so tested exhibited antioxidant and antiradical properties to varying degrees. Methyl ferulate showed the strongest antioxidant activity, whereas the parent phenolic acid was the most active ferulate to scavenge the DPPH radical (DPPH·). Isoferulic acid at concentrations ranging from 10 to 100 nmol/assay did not impart an antiradical efficacy; this may be attributed to the location of the hydroxyl group in the meta position on the aromatic ring.

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Wang, Xiaozhen, Xican Li, and Dongfeng Chen. "Evaluation of Antioxidant Activity of Isoferulic Acid in vitro." Natural Product Communications 6, no. 9 (September 2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600919.

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Isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA), the isomer of ferulic acid (4-hydroxy-3-methoxycinnamic acid), is a rare phenolic acid occurring in Rhizoma Cimicifugae. Unlike ferulic acid, which has been well investigated, the antioxidant activity of IFA has not been measured. In this study, IFA was systematically evaluated for its in vitro antioxidant activity for the first time. IC50 values were calculated of 7.30±0.57, 4.58±0.17, 1.08±0.01, 8.84±0.43, 7.69±0.39, 1.57±0.2, 13.33±0.49 μg/mL, respectively, for lipid peroxidation, DPPH (1,1-diphenyl-2-picrylhydrazyl radical) and ABTS (3-ethylbenzthiazoline-6-sulfonic acid diammonium salt) radical scavenging, reducing power on Fe3+ and Cu2+ ions, and hydroxyl and superoxide anion radical scavenging. Comparison with the IC50 values with those of the positive controls, Trolox and butylated hydroxyanisole (BHA), it can be concluded that isoferulic acid is an effective natural antioxidant in both lipid and aqueous media.

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Terencio, M. C., R. M. Giner, M. J. Sanz, S. Máñez, and J. L. Ríos. "On the Occurrence of Caffeoyltartronic Acid and Other Phenolics in Chondrilla juncea." Zeitschrift für Naturforschung C 48, no. 5-6 (June 1, 1993): 417–19. http://dx.doi.org/10.1515/znc-1993-5-603.

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Abstract Caffeoyltartronic acid and other eleven phenolic com pounds were identified in the MeOH extract of Chondrilla juncea: the flavonoids luteolin, luteolin-7-glucoside, luteolin-7-galactosylglucuronide and quercetin-3-galactoside; the phenolic acids protocatechuic, caffeic, chlorogenic, isochlorogenic and isoferulic and the coumarins cichoriin and aesculetin. The taxonomic im plications of these com pounds have been discussed.

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Kalinowska, Monika, Ewelina Gołębiewska, Liliana Mazur, Hanna Lewandowska, Marek Pruszyński, Grzegorz Świderski, Marta Wyrwas, Natalia Pawluczuk, and Włodzimierz Lewandowski. "Crystal Structure, Spectroscopic Characterization, Antioxidant and Cytotoxic Activity of New Mg(II) and Mn(II)/Na(I) Complexes of Isoferulic Acid." Materials 14, no. 12 (June 11, 2021): 3236. http://dx.doi.org/10.3390/ma14123236.

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The Mg(II) and heterometallic Mn(II)/Na(I) complexes of isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA) were synthesized and characterized by infrared spectroscopy FT-IR, FT-Raman, electronic absorption spectroscopy UV/VIS, and single-crystal X-ray diffraction. The reaction of MgCl2 with isoferulic acid in the aqueous solutions of NaOH resulted in synthesis of the complex salt of the general formula of [Mg(H2O)6]⋅(C10H9O4)2⋅6H2O. The crystal structure of this compound consists of discrete octahedral [Mg(H2O)6]2+ cations, isoferulic acid anions and solvent water molecules. The hydrated metal cations are arranged among the organic layers. The multiple hydrogen-bonding interactions established between the coordinated and lattice water molecules and the functional groups of the ligand stabilize the 3D architecture of the crystal. The use of MnCl2 instead of MgCl2 led to the formation of the Mn(II)/Na(I) complex of the general formula [Mn3Na2(C10H7O4)8(H2O)8]. The compound is a 3D coordination polymer composed of centrosymmetric pentanuclear subunits. The antioxidant activity of these compounds was evaluated by assays based on different antioxidant mechanisms of action, i.e., with •OH, DPPH• and ABTS•+ radicals as well as CUPRAC (cupric ions reducing power) and lipid peroxidation inhibition assays. The pro-oxidant property of compounds was measured as the rate of oxidation of Trolox. The Mg(II) and Mn(II)/Na(I) complexes with isoferulic acid showed higher antioxidant activity than ligand alone in DPPH (IFA, IC50 = 365.27 μM, Mg(II) IFA IC50 = 153.50 μM, Mn(II)/Na(I) IFA IC50 = 149.00 μM) and CUPRAC assays (IFA 40.92 μM of Trolox, Mg(II) IFA 87.93 μM and Mn(II)/Na(I) IFA 105.85 μM of Trolox; for compounds’ concentration 10 μM). Mg(II) IFA is a better scavenger of •OH than IFA and Mn(II)/Na(I) IFA complex. There was no distinct difference in ABTS•+ and lipid peroxidation assays between isoferulic acid and its Mg(II) complex, while Mn(II)/Na(I) complex showed lower activity than these compounds. The tested complexes displayed only slight antiproliferative activity tested in HaCaT human immortalized keratinocyte cell line within the solubility range. The Mn(II)/Na(I) IFA (16 μM in medium) caused an 87% (±5%) decrease in cell viability, the Mg salt caused a comparable, i.e., 87% (±4%) viability decrease in a concentration of 45 μM, while IFA caused this level of cell activity attenuation (87% ± 5%) at the concentration of 1582 μM (significant at α = 0.05).

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Zhang, Ting Ting, Wei Hu, and Dian Zhang. "Allelopathic Effect of Typha Angustifolia L. on Phytoplankton." Advanced Materials Research 383-390 (November 2011): 3724–28. http://dx.doi.org/10.4028/www.scientific.net/amr.383-390.3724.

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To pursue an effective method to control phytoplankton blooms, the allelochemicals of Typha angustifolia L. were purified and identified and their allelopathic effects were studied in phytoplankton assemblage assays. We found that the Typha angustifolia L. allelochemicals included 3 phenic acids (o-hydroxycinnamic acid, syringic acid and isoferulic acid, which inhibited the growth of phytoplankton assemblage and the o-hydroxycinnamic acid proved most potent. The combined activity of these phenic acids exerted synergistic inhibitory effects on the growth of phytoplankton assemblage. The results suggested that Typha angustifolia L. and its allelochemicals may control the phytoplankton blooms in eutrophic waters.

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Liu, I.-Min, Feng-Lin Hsu, Chieh-Fu Chen, and Juei-Tang Cheng. "Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats." British Journal of Pharmacology 129, no. 4 (February 2000): 631–36. http://dx.doi.org/10.1038/sj.bjp.0703082.

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Si, Dandan, Xiaohong Sun, Dandan Qi, Xiaohui Chen, and Kaishun Bi. "Determination and pharmacokinetics of isoferulic acid in rat plasma by high-performance liquid chromatography after oral administration of isoferulic acid and Rhizoma Cimicifugae extract." Journal of Pharmaceutical and Biomedical Analysis 47, no. 1 (May 2008): 140–45. http://dx.doi.org/10.1016/j.jpba.2007.12.044.

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Dang, Phu Hoang, Phuong Thi Yen Duong, Trong Nguyen Huu Phan, Thy Anh Nguyen, and Nhan Trung Nguyen. "Investigation of chemical constituents of the leaves from Kalanchoe pinnata L. (Crassulaceae)." Science and Technology Development Journal 16, no. 2 (June 30, 2013): 47–52. http://dx.doi.org/10.32508/stdj.v16i2.1451.

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From the chloroform and ethyl acetate extracts of the leaves of Kalanchoe pinnata L. (Crassulaceae), two flavonoids and three phenolic compounds were isolated; named quercetin (1), 5,7,4’-trihydroxy-8,3’-dimethoxyflavone (2), gallic acid (3), ferulic acid (4) and isoferulic acid (5). Based on the NMR spectroscopy, their chemical structures were elucidated and the result was confirmed by comparison with published data.

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Serreli, Gabriele, Melanie Le Sayec, Estelle Thou, Camille Lacour, Camilla Diotallevi, Misbah Arshad Dhunna, Monica Deiana, Jeremy P. E. Spencer, and Giulia Corona. "Ferulic Acid Derivatives and Avenanthramides Modulate Endothelial Function through Maintenance of Nitric Oxide Balance in HUVEC Cells." Nutrients 13, no. 6 (June 12, 2021): 2026. http://dx.doi.org/10.3390/nu13062026.

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Wholegrain oats contain a variety of phenolic compounds thought to help maintain healthy vascular function, through the maintenance of local levels of the vasodilator nitric oxide (NO). Thus, the full molecular mechanisms involved are not yet clear. With this work we aim to understand the possible cellular mechanisms by which avenanthramides and ferulic acid derivatives, present in oats, may help maintain a healthy vascular function through the modulation of the NO pathway. Primary Human Umbilical Vein Endothelial Cells (HUVEC) were exposed to ferulic acid, isoferulic acid, hydroferulic acid, ferulic acid 4-O-glucuronide, isoferulic acid 3-O-sulfate, dihydroferulic acid 4-O-glucuronide, avenanthramide A, avenanthramide B and avenanthramide C (1 μM) or vehicle (methanol) for 24 h. Apocynin and Nω-Nitro-L-arginine (L-NNA) were additionally included as controls. NO and cyclic GMP (cGMP) levels, superoxide production and the activation of the Akt1/eNOS pathway were assessed. The statistical analysis was performed using one-way ANOVA followed by a Tukey post-hoc t-test. Apocynin and all phenolic compounds increased NO levels in HUVEC cells (increased DAF2-DA fluorescence and cGMP), and significantly reduced superoxide levels. Protein expression results highlighted an increase in the Akt1 activation state, and increased eNOS expression. Overall, our results indicated that the glucuronide metabolites do not enhance NO production through the Akt1/eNOS pathway, thus all compounds tested are able to reduce NO degradation through reduced superoxide formation.

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Schmid, Diethart, Florian Woehs, Martin Svoboda, Theresia Thalhammer, Peter Chiba, and Thomas Moeslinger. "Aqueous extracts ofCimicifuga racemosaand phenolcarboxylic constituents inhibit production of proinflammatory cytokines in LPS-stimulated human whole blood." Canadian Journal of Physiology and Pharmacology 87, no. 11 (November 2009): 963–72. http://dx.doi.org/10.1139/y09-091.

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Cimicifuga racemosa (black cohosh) is commonly used in traditional medicines as treatment for menopausal symptoms and as an antiinflammatory remedy. To clarify the mechanism of action and active principle for the antiinflammatory action, the effects of aqueous C. racemosa root extracts (CRE) and its major constituents on the release of the proinflammatory cytokines IL-6, TNF-α, IFN-γ, and the chemokine IL-8 were investigated in lipopolysaccharide (LPS)-stimulated whole blood of healthy volunteers. CRE (3 µg/µL and 6 µg/µL) reduced LPS-induced release of IL-6 and TNF-α in a concentration- and time-dependent manner and almost completely blocked release of IFN-γ into the plasma supernatant. Except for IFN-γ, these effects were attenuated at longer incubation periods. IL-8 secretion was stimulated by CRE. As shown by quantitative real-time RT-PCR, effects on cytokines were based on preceding changes in mRNA levels except for IL-8. According to their content in CRE, the phenolcarboxylic compounds caffeic acid, ferulic acid, and isoferulic acid, as well as the triterpene glycosides 23-epi-26-deoxyactein and cimigenol-3-O-xyloside, were tested at representative concentrations. Among these, isoferulic acid was the prominent active principle in CRE, responsible for the observed inhibition of IL-6, TNF-α, and IFN-γ, but not for IL-8 stimulation. The effect of this compound may explain the antiinflammatory activities of CRE and its beneficial actions in rheumatism and other inflammatory diseases.

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Krzaczek, W., and T. Krzaczek. "Phenolic acids of native species of the Rosa L. genus in Poland." Acta Societatis Botanicorum Poloniae 48, no. 2 (2015): 327–36. http://dx.doi.org/10.5586/asbp.1979.027.

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Phenolic acids were identified in the leaves of 23 species of native roses and their quantitative proportions were determined by the method of two-dimensional paper chromatography. The common occurrence of ellagic and gallic acid in roses was confirmed and so was the regular presence of protocatechuic, caffeic, gentisic, p-hydroxybenzoic, p-hydroxyphenylacetic, p-cumaric, syringic, vanillic, ferulic and salicylic acids. A small amount of isoferulic acid was noted only in Rosa gizellae Borb. and R. eglanteria L. var. comosa (Ripart) Du Mortier. Homoprotocatechuic acid was revealed only in the species of the Rosa rubiginosa and Rosa tomentosa groups from the Caninae section. The taxonomically limited occurrence of some phenolic acids points to the systematic differentiating value of the latter within one genus.

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Sakai, Shinya, Hiroshi Ochiai, Naoki Mantani, Toshiaki Kogure, Naotoshi Shibahara, and Katsutoshi Terasawa. "Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice." Mediators of Inflammation 10, no. 2 (2001): 93–96. http://dx.doi.org/10.1080/09629350120054572.

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Background: Isoferulic acid (IFA) is a main active ingredient of the rhizoma ofCimicifuga heracleifolia, which is used frequently in Japanese traditional medicine as an anti-inflammatory drug. It has been revealed that IFA inhibits the production of macrophage inflammatory protein-2 (MIP-2), which is a murine counterpart of the chemokine family that may contribute to the pathogenesis of inflammatory diseases through the chemotactic activity for inflammatory and immune effector cells.Aim of the study: In this study, we investigated the therapeutic effect of IFA on the progression of lethal influenza virus pneumonia in mice by comparison with that of dexamethasone (DX), a potent inhibitor for various inflammatory cytokines including MIP-2.Methods: Mice were infected by intranasal inoculation of influenza virus under ether anesthesia. The IFA or DX was given by oral administration once daily for 4 days after infection. After infection, the survival rate and the change in body weight were daily monitored.Results: IFA administration markedly improved the survival rate and body weight loss of influenza virusinfected mice in a suitable dose range (0.5 mg/day). However, DX administration did not show a beneficial effect at any dose.Conclusion: These data suggested that IFA is a novel tool not only for the intervention therapy, but also for the studies on the pathogenesis of influenza virusinduced pneumonia.

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Sakai, S., H. Kawamata, T. Kogure, N. Mantani, K. Terasawa, M. Umatake, and H. Ochiai. "Inhibitory Effect of Ferulic Acid and Isoferulic Acid on the Production of Macrophage Inflammatory Protein-2 in Response to Respiratory Syncytial Virus Infection in RAW264.7 Cells." Mediators of Inflammation 8, no. 3 (1999): 173–75. http://dx.doi.org/10.1080/09629359990513.

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We investigated the effect of ferulic acid (FA) and isoferulic acid (IFA), which are the main active components of the rhizoma ofCimicifuga heracleifolia(CH), an anti-inflammatory drug used frequently in Japanese traditional medicine, on the production of macrophage inflammatory protein-2 (MIR-2) in a murine macrophage cell line, RAW264.7, in response to respiratory syncytial virus (RSV) infection. Following the exposure of cells to RSV for 20 h, the MIP-2 level in condition medium was increased to about 20 ng/ml, although this level in mock-infected cells was negligible. In the presence of either FA or IFA, RSV-infected cells reduced MIP-2 production in a dose-dependent manner. These data suggest that FA and IFA might be responsible, at least in part, for the anti-inflammatory drug effect of CH extract through the inhibition of MIP-2 production.

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Borges, M. Fernanda M., Fernanda M. F. Roleira, and Madalena M. M. Pinto. "Isocratic HPLC Separation of Scopoletin andCis/TransIsomers of Ferulic Acid as Well as Isoscopoletin andCis/TransIsomers of Isoferulic Acid." Journal of Liquid Chromatography 14, no. 12 (July 1991): 2307–16. http://dx.doi.org/10.1080/01483919108049693.

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Zhang, Jinli, Yan Ding, Haizhou Dong, Hanxue Hou, and Xiansheng Zhang. "Distribution of Phenolic Acids and Antioxidant Activities of Different Bran Fractions from Three Pigmented Wheat Varieties." Journal of Chemistry 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/6459243.

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Phenolic acid profiles and antioxidant activities of outer bran, coarse bran, and shorts from blue, black, and purple wheat were analyzed. Phenolic acids were mainly in the bound form in pigmented wheat bran fractions. Phenolic acid content decreased in the order of outer bran, coarse bran, and shorts for the three pigmented wheat varieties. HPLC analysis of phenolic extracts demonstrated that the bound form of phenolic acids contained more ferulic, isoferulic, and p-coumaric acids compared to their free counterparts. Among the three pigmented wheat varieties, the bran fractions from blue wheat contained higher bound phenolic acids than the other two pigmented wheat bran fractions, except for purple coarse bran. The blue wheat outer bran had the highest total bound phenolic acid of 3458.71 μg/g while the purple wheat shorts had the lowest of 1730.71 μg/g. The contribution of bound phenolic acids to the total phenolic content and antioxidant activity was significantly higher than that of free phenolic acids. Blue wheat bran fractions had the highest radical scavenging activity against DPPH∙ while those of purple wheat gained the highest ABTS∙+ scavenging activity. High correlations were observed between TPC and radical scavenging capacities for DPPH and ABTS (R2>0.85, P<0.05).

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Meeprom, Aramsri, Weerachat Sompong, Catherine Chan, and Sirichai Adisakwattana. "Isoferulic Acid, a New Anti-Glycation Agent, Inhibits Fructose- and Glucose-Mediated Protein Glycation in Vitro." Molecules 18, no. 6 (May 30, 2013): 6439–54. http://dx.doi.org/10.3390/molecules18066439.

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Liu, I.-Min, Wang-Chuan Chen, and Juei-Tang Cheng. "Mediation of β-Endorphin by Isoferulic Acid to Lower Plasma Glucose in Streptozotocin-Induced Diabetic Rats." Journal of Pharmacology and Experimental Therapeutics 307, no. 3 (September 15, 2003): 1196–204. http://dx.doi.org/10.1124/jpet.103.053900.

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Lu, Wen, Fang Wang, Tao Zhang, Jinyun Dong, Hongping Gao, Ping Su, Yaling Shi, and Jie Zhang. "Search for novel histone deacetylase inhibitors. Part II: Design and synthesis of novel isoferulic acid derivatives." Bioorganic & Medicinal Chemistry 22, no. 9 (May 2014): 2707–13. http://dx.doi.org/10.1016/j.bmc.2014.03.019.

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Sha, Na, Hui-Lian Huang, Jin-Qiang Zhang, Guang-Tong Chen, Si-Jia Tao, Min Yang, Xing-Nuo Li, Ping Li, and De-An Guo. "Simultaneous Quantification of Eight Major Bioactive Phenolic Compounds in Chinese Propolis by High-Performance Liquid Chromatography." Natural Product Communications 4, no. 6 (June 2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400615.

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A simple, sensitive and specific high-performance liquid chromatography-UV (HPLC-UV) method has been developed to simultaneously quantify the eight major bioactive phenolic compounds in Chinese propolis, namely caffeic acid, isoferulic acid, 3,4-dimethoxycinnamic acid, pinobanksin 5-methyl ether, pinocembrin, benzyl caffeate, chrysin and galangin. This HPLC assay was performed on an Agilent Zorbax Extend-C18 (250 × 4.6 mm, 5 μm) column with a gradient of methanol and 0.2% aqueous acetic acid (v/v) in 50 min, at a flow rate of 1.0 mL/min, and detected at 290 nm. All calibration curves showed good linearity (r2 >0.999) within the test ranges. The intra- and inter-day assay precision (RSD) of eight phenolic compounds were in the range of 0.07-4.92%. The recoveries were between 98.3% and 104.8%. This assay was applied to the evaluation of nineteen samples from different origins in China. The results indicated that the developed assay could be readily utilized for the quality control of propolis.

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Serreli, Gabriele, Micaela Rita Naitza, Sonia Zodio, Vera Piera Leoni, Martina Spada, Maria Paola Melis, Anna Boronat, and Monica Deiana. "Ferulic Acid Metabolites Attenuate LPS-Induced Inflammatory Response in Enterocyte-like Cells." Nutrients 13, no. 9 (September 10, 2021): 3152. http://dx.doi.org/10.3390/nu13093152.

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Ferulic acid (FA) is a polyphenol pertaining to the class of hydroxycinnamic acids present in numerous foods of a plant origin. Its dietary consumption leads to the formation of several phase I and II metabolites in vivo, which represent the largest amount of ferulates in the circulation and in the intestine in comparison with FA itself. In this work, we evaluated their efficacy against the proinflammatory effects induced by lipopolysaccharide (LPS) in intestinal Caco-2 cell monolayers, as well as the mechanisms underlying their protective action. LPS-induced overexpression of proinflammatory enzymes such as inducible nitric oxide synthase (iNOS) and the consequent hyperproduction of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) were limited by physiological relevant concentrations (1 µM) of FA, its derivatives isoferulic acid (IFA) and dihydroferulic acid (DHFA), and their glucuronidated and sulfated metabolites, which acted upstream by limiting the activation of MAPK p38 and ERK and of Akt kinase, thus decreasing the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ĸB) translocation into the nucleus. Furthermore, the compounds were found to promote the expression of Nrf2, which may have contributed to the downregulation of NF-ĸB activity. The overall data show that phase I/II metabolites retain the efficacy of their dietary free form in contrasting inflammatory response.

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Xuan, Hongzhuan, Yuehua Wang, Aifeng Li, Chongluo Fu, Yuanjun Wang, and Wenjun Peng. "Bioactive Components of Chinese Propolis Water Extract on Antitumor Activity and Quality Control." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/9641965.

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To understand the material basis of antitumor activity of Chinese propolis water extract (CPWE), we developed a simple and efficient method using macroporous absorptive resin coupled with preparative high performance liquid chromatography and separated and purified eleven chemical components (caffeic acid, ferulic acid, isoferulic acid, 3,4-dimethoxycinnamic acid, pinobanksin, caffeic acid benzyl ester, caffeic acid phenethyl ester, apigenin, pinocembrin, chrysin, and galangin) from CPWE; then we tested the antitumor activities of these eleven components using different human tumor cell lines (MCF-7, MDA-MB-231, HeLa, and A549). Furthermore, cell migration, procaspase 3 level, and reactive oxygen species (ROS) of effective components from CPWE were investigated. Our data showed that antitumor activities of the eleven components from CPWE were different from each other. CPWE and its effective components induced apoptosis by inhibiting tumor cell migration, activating caspase 3, and promoting ROS production. It can be deduced that the antitumor effects of propolis did not depend on a single component, and there must exist “bioactive components,” which also provides a new idea for Chinese propolis quality control.

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Jairajpuri, D. S., and Z. S. Jairajpuri. "Isoferulic acid action against glycation-induced changes in structural and functional attributes of human high-density lipoprotein." Biochemistry (Moscow) 81, no. 3 (March 2016): 289–95. http://dx.doi.org/10.1134/s0006297916030123.

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Hirabayashi, Tatsuji, Hiroshi Ochiai, Shinya Sakai, Katsuhisa Nakajima, and Katsutoshi Terasawa. "Inhibitory Effect of Ferulic Acid and Isoferulic Acid on Murine Interleukin-8 Production in Response to Influenza Virus Infectionsin vitroandin vivo." Planta Medica 61, no. 03 (June 1995): 221–26. http://dx.doi.org/10.1055/s-2006-958060.

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Nyandwi, Ramadhan, Ayşe S. Kılıç, Meltem Çelik, and Hasan H. Oruç. "Determination and Quantification of Gallic Acid in Raw Propolis by High-performance Liquid Chromatography–Diode Array Detector in Burundi." East Africa Science 1, no. 1 (March 25, 2019): 43–48. http://dx.doi.org/10.24248/easci.v1.iss1.18.

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Background: Honey, pollen, and propolis are among the products that bees process and derive from plants and flowers. Propolis is a resinous material that bees gather from the buds and bark of some trees and small plants. Propolis from temperate climates mainly contains phenolic compounds, in contrast with propolis from tropical climates, which mainly contains terpenes. This study aimed to determine, characterise, and quantify the phenolic content of raw propolis from Burundi. Methods: In this study, a total of 6 samples were collected from the provinces of Rumonge, Cibitoke, and Ruyigi in Burundi. Fifteen phenolic compounds (caffeic acid, ferulic acid, epigallocatechin gallate, isoferulic acid, cinnamic acid, caffeic acid phenethyl ester, gallic acid, apigenin, chrysin, galangin, quercetin, kaempherol, rutin trihydrate, naringenin, and pinocembrin) were used as high-performance liquid chromatography (HPLC) standards for qualitative and quantitative analyses of the propolis samples. Results: Among the 15 phenolic compounds checked, only 1 – gallic acid – was detected at a measurable level using an HPLC-diode array detector system. Conclusion: In addition to terpenes, propolis found in sub-Saharan Africa may contain phenolic compounds. Further advanced investigation of sub-Saharan African propolis is required for more detailed characterisation.

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Nyandwi, Ramadhan, Ayşe S. Kılıç, Meltem Çelik, and Hasan H. Oruç. "Determination and Quantification of Gallic Acid in Raw Propolis by High-performance Liquid Chromatography–Diode Array Detector in Burundi." East Africa Science 1, no. 1 (March 25, 2019): 43–48. http://dx.doi.org/10.24248/easci.v1i1.9.

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Background: Honey, pollen, and propolis are among the products that bees process and derive from plants and flowers. Propolis is a resinous material that bees gather from the buds and bark of some trees and small plants. Propolis from temperate climates mainly contains phenolic compounds, in contrast with propolis from tropical climates, which mainly contains terpenes. This study aimed to determine, characterise, and quantify the phenolic content of raw propolis from Burundi. Methods: In this study, a total of 6 samples were collected from the provinces of Rumonge, Cibitoke, and Ruyigi in Burundi. Fifteen phenolic compounds (caffeic acid, ferulic acid, epigallocatechin gallate, isoferulic acid, cinnamic acid, caffeic acid phenethyl ester, gallic acid, apigenin, chrysin, galangin, quercetin, kaempherol, rutin trihydrate, naringenin, and pinocembrin) were used as high-performance liquid chromatography (HPLC) standards for qualitative and quantitative analyses of the propolis samples. Results: Among the 15 phenolic compounds checked, only 1 – gallic acid – was detected at a measurable level using an HPLC-diode array detector system. Conclusion: In addition to terpenes, propolis found in sub-Saharan Africa may contain phenolic compounds. Further advanced investigation of sub-Saharan African propolis is required for more detailed characterisation.

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Hori, Kengo, Takashi Watanabe, and Hari Prasad Devkota. "Phenolic Acid Derivatives, Flavonoids and Other Bioactive Compounds from the Leaves of Cardiocrinum cordatum (Thunb.) Makino (Liliaceae)." Plants 10, no. 2 (February 7, 2021): 320. http://dx.doi.org/10.3390/plants10020320.

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Cardiocrinum cordatum (Thunb.) Makino (Family: Liliaceae), commonly known as ‘Ubayuri’, is native to Japan and some islands in the Russian Far East. It has high value as food, medicinal, and ornamental species. The aim of this study was to isolate and characterize the main chemical constituents of the leaves of C. cordatum. A total of 19 compounds, namely caffeic acid (1), caffeic acid methyl ester (2), caffeic acid β-glucopyranosyl ester (3), caffeic acid 4-O-β-glucopyranoside (4), ferulic acid (5), isoferulic acid (6), protocatechuic acid (7), syringic acid (8), 2,6-dimethoxy-p-hydroquinone 1-O-β-glucopyranoside (9), esculetin (10), taxifolin (11), quercetin 3-O-(6-O-α-rhamnopyranosyl)β-glucopyranoside-7-O-β-rhamnopyranoside (12), 2,7-dimethyl-2,4-diene-deca-α,ω-diacid β-glucopyranoside (13), 4-[formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoic acid (14), (3Z)-3-hexenyl β-glucopyranoside (15), tryptophan (16), adenine (17), adenosine (18), and 2-deoxyadenosine (19) were isolated using various chromatographic methods. The structures of isolated compounds were elucidated on the basis of their NMR spectroscopic data. All these compounds were isolated for the first time from the genus Cardiocrinum. Phenolic acid derivatives and flavonoids can be considered as chemotaxonomic markers in the leaves of Cardiocrinum species.

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Jiang, Li, Minhao Xie, Guijie Chen, Jiangtao Qiao, Hongcheng Zhang, and Xiaoxiong Zeng. "Phenolics and Carbohydrates in Buckwheat Honey Regulate the Human Intestinal Microbiota." Evidence-Based Complementary and Alternative Medicine 2020 (February 26, 2020): 1–11. http://dx.doi.org/10.1155/2020/6432942.

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Intestinal microbiota plays an important role in human health. The aim of this paper is to determine the impact of the phenolics and carbohydrate in buckwheat honey on human intestinal microbiota. We investigated the phenolics and carbohydrate compositions of eight buckwheat honey samples using high-performance liquid chromatography and ion chromatography. The human intestinal microbes were cultured in a medium supplemented with eight buckwheat honey samples or the same concentration of fructooligosaccharides. The bacterial 16S rDNA V4 region sequence of DNA extraction was determined by the Illumina MiSeq platform. 12 phenolics and 4 oligosaccharides were identified in almost all buckwheat honey samples, namely, protocatechuic acid, 4-hydroxy benzoic acid, vanillin, gallic acid, p-coumaric acid, benzoic acid, isoferulic acid, methyl syringate, trans,trans-abscisic acid, cis,trans-abscisic acid, ferulic acid, 4-hydroxybenzaldehyde, kestose, isomaltose, isomaltotriose, and panose. Most notably, this is the first study to reveal the presence of 4-hydroxybenzaldehyde in buckwheat honey. 4-Hydroxybenzaldehyde seems to be a land marker of buckwheat honey. Our results indicate that buckwheat honey can provide health benefits to the human gut by selectively supporting the growth of indigenous Bifidobacteria and restraining the pathogenic bacterium in the gut tract. We infer that buckwheat honey may be a type of natural intestinal-health products.

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Jiang, Xiasen, Linchen Tao, Chunguang Li, Mengmeng You, George Q. Li, Cuiping Zhang, and Fuliang Hu. "Grouping, Spectrum–Effect Relationship and Antioxidant Compounds of Chinese Propolis from Different Regions Using Multivariate Analyses and Off-Line Anti-DPPH Assay." Molecules 25, no. 14 (July 16, 2020): 3243. http://dx.doi.org/10.3390/molecules25143243.

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49 samples of propolis from different regions in China were collected and analyzed for their chemical compositions, contents of total flavonoids (TFC), total phenolic acid (TPC) and antioxidant activity. High-performance liquid chromatography (HPLC) analysis identified 15 common components, including key marker compounds pinocembrin, 3-O-acetylpinobanksin, galangin, chrysin, benzyl p-coumarate, pinobanksin and caffeic acid phenethyl ester (CAPE). Cluster analysis (CA) and correlation coefficients (CC) analysis showed that these propolis could be divided into three distinct groups. Principal component analysis (PCA) and multiple linear regression analysis (MLRA) revealed that the contents of isoferulic acid, caffeic acid, CAPE, 3,4-dimethoxycinnamic acid, chrysin and apigenin are closely related to the antioxidant properties of propolis. In addition, eight peak areas decreased after reacting with 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radicals, indicating that these compounds have antioxidant activity. The results indicate that the grouping and spectrum–effect relationship of Chinese propolis are related to their chemical compositions, and several compounds may serve as a better marker for the antioxidant activity of Chinese propolis than TFC and TPC. The findings may help to develop better methods to evaluate the quality of propolis from different geographic origins.

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Liu, I.-Min, Tzong-Cherng Chi, Feng-Lin Hsu, Chieh-Fu Chen, and Juei-Tang Cheng. "Isoferulic Acid as Active Principle from the Rhizoma of Cimicifuga dahurica to Lower Plasma Glucose in Diabetic Rats." Planta Medica 65, no. 8 (December 1999): 712–14. http://dx.doi.org/10.1055/s-1999-14048.

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Renouf, Mathieu, Philippe Guy, Cynthia Marmet, Karin Longet, Anne-Lise Fraering, Julie Moulin, Denis Barron, et al. "Plasma appearance and correlation between coffee and green tea metabolites in human subjects." British Journal of Nutrition 104, no. 11 (August 9, 2010): 1635–40. http://dx.doi.org/10.1017/s0007114510002709.

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Coffee and green tea are two of the most widely consumed hot beverages in the world. Their respective bioavailability has been studied separately, but absorption of their respective bioactive phenolics has not been compared. In a randomised cross-over design, nine healthy subjects drank instant coffee and green tea. Blood samples were collected over 12 h and at 24 h to assess return to baseline. After green tea consumption, ( − )-epigallocatechin (EGC) was the major catechin, appearing rapidly in the plasma; ( − )-EGC gallate (EGCg) and ( − )-epicatechin (EC) were also present, but ( − )-EC gallate and C were not detected. Dihydroferulic acid and dihydrocaffeic acid were the major metabolites that appeared after coffee consumption with a long time needed to reach maximum plasma concentration, suggesting metabolism and absorption in the colon. Other phenolic acid equivalents (caffeic acid (CA), ferulic acid (FA) and isoferulic acid (iFA)) were detected earlier, and they peaked at lower concentrations. Summations of the plasma area under the curves (AUC) for the measured metabolites showed 1·7-fold more coffee-derived phenolic acids than green tea-derived catechins (P = 0·0014). Furthermore, we found a significant correlation between coffee metabolites based on AUC. Inter-individual differences were observed, but individuals with a high level of CA also showed a correspondingly high level of FA. However, no such correlation was observed between the tea catechins and coffee phenolic acids. Correlation between AUC and maximum plasma concentration was also significant for CA, FA and iFA and for EGCg. This implies that the mechanisms of absorption for these two classes of compounds are different, and that a high absorber of phenolic acids is not necessarily a high absorber of catechins.

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Oniszczuk, Widelska, Wójtowicz, Oniszczuk, Wojtunik-Kulesza, Dib, and Matwijczuk. "Content of Phenolic Compounds and Antioxidant Activity of New Gluten-Free Pasta with the Addition of Chestnut Flour." Molecules 24, no. 14 (July 18, 2019): 2623. http://dx.doi.org/10.3390/molecules24142623.

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Chestnut fruit abounds in carbohydrates, proteins, unsaturated fatty acids, fiber, polyphenolic compounds, as well as vitamins and micronutrients, that are behind the health-promoting properties of this plant. The purpose of the discussed research was to obtain innovative gluten-free pasta from rice and field bean flour enriched with a various addition of chestnut flour. Regarding the studied pasta, the following were determined: the content of free phenolic acids, total polyphenols, and antioxidant properties. Chromatographic analysis (HPLC-ESI-MS/MS (high-performance liquid chromatography-electrospray ionization tandem mass spectrometry)) revealed a wide variety of phenolic acids. In a sample with 20% and higher content of chestnut flour, as many as 13 acids were detected. Isoferulic acid prevailed. The total content of free phenolic acids and total polyphenols increased along with the increasing chestnut content. Moreover, in most cases, the content of individual acids increased with the addition of chestnut flour. Besides, the antioxidant activity was positively correlated with the addition of chestnut fruit flour, the content of free phenolic acids, and total polyphenols. Our research has demonstrated that our innovative gluten-free pasta, with the addition of chestnut flour, has a potential to be a source of polyphenolic compounds, including free phenolic acids, that are valuable for human health.

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Guo, Xiaorui, Xiaohui Chen, Weiming Cheng, Kaiyu Yang, Yongfen Ma, and Kaishun Bi. "RP-LC Determination and Pharmacokinetic Study of Ferulic Acid and Isoferulic Acid in Rat Plasma After Taking Traditional Chinese Medicinal-Preparation: Guanxinning Lyophilizer." Chromatographia 67, no. 11-12 (April 18, 2008): 1007–11. http://dx.doi.org/10.1365/s10337-008-0614-6.

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Liu, I.-Min, Chin-Chuan Tsai, Tung-Yuan Lai, and Juei-Tang Cheng. "Stimulatory effect of isoferulic acid on α1A-adrenoceptor to increase glucose uptake into cultured myoblast C2C12 cell of mice." Autonomic Neuroscience 88, no. 3 (May 2001): 175–80. http://dx.doi.org/10.1016/s1566-0702(01)00241-7.

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Al-Amier, Hussein, Khaled A. Nasr, Lorna Lück, and Lyle E. Craker. "(390) Chemotype Variation among Black Cohosh Populations." HortScience 40, no. 4 (July 2005): 1032E—1033. http://dx.doi.org/10.21273/hortsci.40.4.1032e.

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Black cohosh [Actaea racemosa L.; syn. Cimicifuga racemosa (L.) Nutt.] is a medicinal plant native to America and the woodlands of eastern North America. The roots and rhizomes of black cohosh, used by Native Americans to ease childbirth and treat menstrual cramps, rheumatism, headaches, coughs, asthma, and snakebites, are currently popular as an herbal remedy in the United States and Europe for the relief of discomfort associated with menopause. To determine chemical variation among populations of this perennial plant, root samples from 33 locations within the natural range of the species, ranging from Massachusetts to South Carolina and west to Missouri and Tennessee, were collected and chemically analyzed by HPLC-PDA using a C-18 reversed phase column (Phenomenex) for separation of the chemical constituents. The constituents were identified by comparison with commercial standards, including actein, methyl-beta-arabinopyranoside, caffeic acid, cimicifugoside, cimicifugoside H1, cimiracemoside A, 26 deoxyactein, ferulic acid, isoferulic acid, kaempferol, formononetin, and others. Chemically, an extract of the root and rhizome is known to contain at least three major natural product groups: cycloartenal-type triterpenes, phenolics, and flavonoids. Chemical constituents, especially formononetin, varied among the populations.

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Olech, Marta, Wioleta Pietrzak, and Renata Nowak. "Characterization of Free and Bound Phenolic Acids and Flavonoid Aglycones in Rosa rugosa Thunb. Leaves and Achenes Using LC–ESI–MS/MS–MRM Methods." Molecules 25, no. 8 (April 15, 2020): 1804. http://dx.doi.org/10.3390/molecules25081804.

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Fast and reliable determination of polyphenols is a quite common goal during investigation of new plant materials and herbal products, their standardization, quality control, or chemo-taxonomical studies. The aim of this study was to develop and validate methods based on the application of reversed phase liquid chromatography/electrospray ionization triple quadrupole mass spectrometry (LC-ESI-MS/MS) using multiple reaction monitoring (MRM) for comprehensive quantitative and qualitative analysis of phenolic acids and flavonoid aglycones. LC-MS/MS-MRM protocols were applied for the determination of free and bound phenolics in a series of plant samples prepared from leaves and achenes (true fruits) of Japanese rose (Rosa rugosa Thunb.). The presence of large amount of phenolic compounds was detected in rose leaves (786.44 µg/g and 14.46 µg/g of phenolic acids and flavonoid aglycones, respectively). Isoferulic acid and five aglycones were revealed for the first time in this plant material. Moreover, 15 phenolic acids and six aglycones were found in the rose achenes, including eight phenolic acids and four aglycones that had not been previously reported in this rose organ. It was shown that leaves and achenes may constitute an industrially relevant source of phenolic compounds for potential commercial use in pharmaceutical, food, or cosmetic industry.

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Martínez, Mario David, Diego Ariel Riva, Cybele Garcia, Fernando Javier Durán, and Gerardo Burton. "Synthesis and Antibacterial Activity of Difluoromethyl Cinnamoyl Amides." Molecules 25, no. 4 (February 12, 2020): 789. http://dx.doi.org/10.3390/molecules25040789.

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Series of novel amides of isoferulic acid, where the phenolic hydroxyl was replaced by a difluoromethyl group, were synthesized and their in vitro antibacterial activities assayed against fourteen bacterial strains (six Gram-positive and eight Gram-negative). A one-pot methodology was developed to obtain the 3′-(difluoromethyl)-4′-methoxycinnamoyl amides using Deoxofluor® as a fluorinating agent. The N-isopropyl, N-isopentyl, and N-(2-phenylethyl) amides 11b, 11d and 11g were the most active and selective against Mycobacterium smegmatis (MIC = 8 µg/mL) with 11b and 11g displaying negligible or no cytotoxicity against HepG2 and A549 cells. Thirteen analogs of N-isopropylamide 11b were also synthesized and their antibacterial activity assayed. Results show that the difluoromethyl moiety enhanced antibacterial activity and selectivity towards M. smegmatis, changing the microorganism inhibition profile of the parent compound. The selectivity exhibited by some of the compounds towards M. smegmatis makes them potential leads in the search for new narrow spectrum antibiotics against M. tuberculosis.

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Chen, Wenbin, Xijuan Tu, Dehui Wu, Zhaosheng Gao, Siyuan Wu, and Shaokang Huang. "Comparison of the Partition Efficiencies of Multiple Phenolic Compounds Contained in Propolis in Different Modes of Acetonitrile–Water-Based Homogenous Liquid–Liquid Extraction." Molecules 24, no. 3 (January 26, 2019): 442. http://dx.doi.org/10.3390/molecules24030442.

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Homogeneous liquid–liquid extraction (HLLE) has attracted considerable interest in the sample preparation of multi-analyte analysis. In this study, HLLEs of multiple phenolic compounds in propolis, a polyphenol-enriched resinous substance collected by honeybees, were performed for improving the understanding of the differences in partition efficiencies in four acetonitrile–water-based HLLE methods, including salting-out assisted liquid–liquid extraction (SALLE), sugaring-out assisted liquid–liquid extraction (SULLE), hydrophobic-solvent assisted liquid–liquid extraction (HSLLE), and subzero-temperature assisted liquid–liquid extraction (STLLE). Phenolic compounds were separated in reversed-phase HPLC, and the partition efficiencies in different experimental conditions were evaluated. Results showed that less-polar phenolic compounds (kaempferol and caffeic acid phenethyl ester) were highly efficiently partitioned into the upper acetonitrile (ACN) phase in all four HLLE methods. For more-polar phenolic compounds (caffeic acid, p-coumaric acid, isoferulic acid, dimethoxycinnamic acid, and cinnamic acid), increasing the concentration of ACN in the ACN–H2O mixture could dramatically improve the partition efficiency. Moreover, results indicated that NaCl-based SALLE, HSLLE, and STLLE with ACN concentrations of 50:50 (ACN:H2O, v/v) could be used for the selective extraction of low-polarity phenolic compounds. MgSO4-based SALLE in the 50:50 ACN–H2O mixture (ACN:H2O, v/v) and the NaCl-based SALLE, SULLE, and STLLE with ACN concentrations of 70:30 (ACN:H2O, v/v) could be used as general extraction methods for multiple phenolic compounds.

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Agulló, Vicente, Débora Villaño, Cristina García-Viguera, and Raúl Domínguez-Perles. "Anthocyanin Metabolites in Human Urine after the Intake of New Functional Beverages." Molecules 25, no. 2 (January 16, 2020): 371. http://dx.doi.org/10.3390/molecules25020371.

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Sugar intake abuse is directly related with the increase of metabolic diseases such as type 2 diabetes, obesity, and insulin resistance. Along this line, the development of new beverages using alternative sweeteners could help with combatting the pathophysiological disorders associated to the consumption of sugar. To provide evidence on this issue, in the present work, the bioavailability of anthocyanins was evaluated after the acute ingestion of a new maqui-citrus-based functional beverage rich in polyphenols, and supplemented with a range of sweeteners including sucrose (natural high caloric), stevia (natural non-caloric), and sucralose (artificial non-caloric), as an approach that would allow reducing the intake of sugars while providing bioactive phenolic compounds (anthocyanins). This approach allowed the evaluation of the maximum absorption and the diversity of metabolites excreted through urine. The beverages created were ingested by volunteers (n = 20) and the resulting anthocyanin metabolites in their urine were analyzed by UHPLC-ESI-MS/MS. A total of 29 degradation metabolites were detected: Caffeic acid, catechol, 3,4-dihidroxifenilacetic acid, hippuric acid, trans-ferulic acid, 2,4,6-trihydroxybenzaldehyde, trans-isoferulic acid, and vanillic acid derivatives, where peak concentrations were attained at 3.5 h after beverage intake. Sucralose was the sweetener that provided a higher bioavailability for most compounds, followed by stevia. Sucrose did not provide a remarkably higher bioavailability of any compounds in comparison with sucralose or stevia. The results propose two sweetener alternatives (sucralose and stevia) to sucrose, an overused high calorie sweetener that promotes some metabolic diseases.

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Agulló, Vicente, Cristina García-Viguera, and Raúl Domínguez-Perles. "Beverages Based on Second Quality Citrus Fruits and Maqui Berry, a Source of Bioactive (Poly)phenols: Sorting Out Urine Metabolites upon a Longitudinal Study." Nutrients 13, no. 2 (January 22, 2021): 312. http://dx.doi.org/10.3390/nu13020312.

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The intake of sugar-sweetened beverages has been associated with an augmented prevalence of metabolic diseases, namely, obesity, type II diabetes, and metabolic syndrome. On the other hand, nowadays, it is broadly accepted that foods and beverages rich in (poly)phenols could contribute to reducing the incidence of these pathologies. In this sense, the objective of the work was to revalue second quality citrus fruits for the development of new beverages, rich in anthocyanins and flavanones (maqui berry and second qualities citrus-based), and evaluate the influence of alternative sweeteners (sucralose, sucrose, or stevia), regarding the bioaccessibility and bioavailability of these bioactive compounds in the frame of a chronic (longitudinal) intervention. To fulfill this objective, a longitudinal study of the urinary excretion of anthocyanins and flavanones, after 2-months of ingestion of the developed maqui-citrus beverage, by 138 volunteers (n = 46 per beverage) and the analysis of the resulting phenolic metabolites by ultra-high performance liquid chromatography coupled to mass spectrometry (UHPLC-ESI-QqQ-MS/MS) was carried out. As major results, the bioavailable metabolites of caffeic acid (CA), catechol (CAT), 3,4-di-hydroxyphenylacetic acid (DHPAA), eriodictyol (E), homoeriodictyol (HE), hippuric acid (HA), naringenin (N), trans-ferulic acid (TFA), 2,4,6-tri-hydroxybenzaldehyde (THBA), trans-isoferulic acid (TIFA), and vanillic acid (VA) were detected. Accordingly, significantly different bioavailability was dependent on the sweetener used, allowing proposing stevia and, to a lower extent, sucralose, as valuable alternatives to sucrose.

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Vauzour, David, Emily J. Houseman, Trevor W. George, Giulia Corona, Roselyne Garnotel, Kim G. Jackson, Christelle Sellier, et al. "Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers." British Journal of Nutrition 103, no. 8 (November 30, 2009): 1168–78. http://dx.doi.org/10.1017/s0007114509992959.

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Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial. We show that consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption. Although both Champagne wine and the control also induced an increase in endothelium-dependent vascular reactivity at 4 h, there was no significant difference between the vascular effects induced by Champagne or the control at any time point. These effects were accompanied by an acute decrease in the concentration of matrix metalloproteinase (MMP-9), a significant decrease in plasma levels of oxidising species and an increase in urinary excretion of a number of phenolic metabolites. In particular, the mean total excretion of hippuric acid, protocatechuic acid and isoferulic acid were all significantly greater following the Champagne wine intervention compared with the control intervention. Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity.

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Oniszczuk, Anna, Agnieszka Wójtowicz, Tomasz Oniszczuk, Arkadiusz Matwijczuk, Ahlem Dib, and Ewa Markut-Miotła. "Opuntia Fruits as Food Enriching Ingredient, the First Step towards New Functional Food Products." Molecules 25, no. 4 (February 18, 2020): 916. http://dx.doi.org/10.3390/molecules25040916.

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Prickly pear (Opuntia ficus indica (L.) Mill.) is a rich source of vitamins C, B1, B2, A, and E, minerals such as calcium, potassium, magnesium, iron, and phosphorus, as well as bioactive substances, i.e., carotenoids, betalains, and phenolic compounds. Of these, the phenolic acids, betalains, and flavonoids are notable in that they are largely responsible for the health-promoting properties of this plant. The purpose of the presented research was to first determine the antioxidant properties and the content of polyphenolic compounds (including individual phenolic acids) in prickly pear fruit, then to produce an innovative gluten-free pasta from rice-field bean flour enriched with various amounts of pear prickly fruit. The content of free phenolic acids, the sum of polyphenols and antioxidant properties of pasta were subsequently determined in the supplemented pasta. Chromatographic analysis (HPLC-ESI-MS/MS) showed a wide variety of phenolic acids. In the fruit sample, 14 acids were detected, whereas in the pasta sample without additives, 9. The dominant acid was isoferulic. The total content of free phenolic acids and the sum of polyphenols increased with increasing content of the functional additive. Moreover, the content of individual acids generally increased as the Opuntia fruit was added. The antioxidant activity was also positively correlated with the addition of fruit, with the content of free phenolic acids and the sum of polyphenols. Our research has shown that our innovative pasta with the addition of prickly fruit can become a source of the free phenolic acids indispensable for human health.

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Arfin, Sadaf, Gufran Ahmed Siddiqui, Aabgeena Naeem, and Shagufta Moin. "Inhibition of advanced glycation end products by isoferulic acid and its free radical scavenging capacity: An in vitro and molecular docking study." International Journal of Biological Macromolecules 118 (October 2018): 1479–87. http://dx.doi.org/10.1016/j.ijbiomac.2018.06.182.

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Meeprom, Aramsri, Catherine B. Chan, Weerachat Sompong, and Sirichai Adisakwattana. "Isoferulic acid attenuates methylglyoxal-induced apoptosis in INS-1 rat pancreatic β-cell through mitochondrial survival pathways and increasing glyoxalase-1 activity." Biomedicine & Pharmacotherapy 101 (May 2018): 777–85. http://dx.doi.org/10.1016/j.biopha.2018.01.017.

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Sánchéz-Cortés, S., and J. V. García-Ramos. "FT Surface-Enhanced Raman Evidence of the Oxidative Condensation Reactions of Caffeic Acid in Solution and on Silver Surface." Applied Spectroscopy 54, no. 2 (February 2000): 230–38. http://dx.doi.org/10.1366/0003702001949159.

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Fourier transform (FT)-Raman spectroscopy and FT surface-enhanced Raman spectroscopy (FT-SERS) are applied for the first time to study the chemical oxidative changes undergone by caffeic acid (CA) in solution and when adsorbed on silver colloids. UV-visible spectroscopy was also applied to follow the polymerization of CA. Normal Raman techniques have only a limited application in the characterization of CA oxidation products owing to the high fluorescence background emitted by them. Nevertheless, the use of silver colloids may both quench the fluorescence signal and catalyze the CA oxidation, with the additional advantage of analyzing very small concentrations of the CA derivatives formed in situ on the surface. The influence of the solvent (water or ethanol) in the oxidation of the stock solution, the pH, and the storage time on the SERS spectra was investigated and analyzed on the basis of the oxidation and polymerization mechanisms proposed by several authors in the literature. The results found for CA were compared with those for other chemically related molecules as catechol and isoferulic acid in order to assign the vibrational spectra obtained at the different conditions employed to carry out the study of CA oxidation. The results found in this study demonstrate that the polymerization mechanism followed by CA depends on the conditions of CA storage and those at which the SERS spectra are recorded. The conclusions derived from this work can be very useful in the understanding of the chemical processes undergone by CA, which lead to possible changes in the nutritional value of the foods where this molecule appears. The advantage of this technique in relation to those employed so far in similar investigations is the ability to carry out in situ time-resolved measurements, thus allowing assignments of the different mechanisms of CA oxidation under the different experimental conditions employed.

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Dilshara, Matharage Gayani, Kyoung-Tae Lee, Rajapaksha Gedara Prasad Tharanga Jayasooriya, Chang-Hee Kang, Sang Rul Park, Yung Hyun Choi, Il-Whan Choi, et al. "Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1." International Immunopharmacology 18, no. 1 (January 2014): 203–11. http://dx.doi.org/10.1016/j.intimp.2013.11.020.

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Hettihewa, Sujeewa, Yacine Hemar, and H. Rupasinghe. "Flavonoid-Rich Extract of Actinidia macrosperma (A Wild Kiwifruit) Inhibits Angiotensin-Converting Enzyme In Vitro." Foods 7, no. 9 (September 5, 2018): 146. http://dx.doi.org/10.3390/foods7090146.

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Increasing interest in flavonoids in kiwifruit is due to the health-promoting properties of these bioactives. Inhibition of the angiotensin-converting enzyme (ACE) is one of the main therapeutic targets in controlling hypertension. The present study investigated the ACE inhibitory activity of flavonoid-rich extracts obtained from different kiwifruit genotypes. The flavonoid-rich extracts were prepared from fruits of Actinidia macrosperma, Actinidia deliciosa cv Hayward (Green kiwifruit), and Actinidia chinensis cv Hort 16A (Gold kiwifruit) by steeping the lyophilized fruit samples in 70% aqueous acetone, followed by partitioning the crude extracts with hexane. The composition of each extract was analyzed using ultrahigh-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). The ACE inhibitory activity of the fruit extracts was performed using a fluorescence-based biochemical assay. The subclass flavonol was the most abundant group of flavonoids detected in all the extracts tested from three different kiwifruit cultivars. Quercetin-3-O-galactoside, quercetin-3-O-glucoside, quercetin-3-O-rhamnoside, quercetin-3-O-rutinoside, quercetin-3-O-arabinoglucoside, catechin, epigallocatechin gallate, epigallocatechin, chlorogenic, ferulic, isoferulic, and caffeic acid were prominent phenolics found in A. macrosperma kiwifruit. Overall, the flavonoid-rich extract from A. macrosperma showed a significantly (p < 0.05) high percentage of inhibition (IC50 = 0.49 mg/mL), and enzyme kinetic studies suggested that it inhibits ACE activity in vitro. The kiwifruit extracts tested were found to be moderately effective as ACE inhibitors in vitro when compared to the other plant extracts reported in the literature. Further studies should be carried out to identify the active compounds from A. macrosperma and to validate the findings using experimental animal models of hypertension.

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Celaya, Liliana, Carmen Viturro, and Luís R. Silva. "Acantholippia salsoloides: Phytochemical Composition and Biological Potential of a Thujonic Population." Natural Product Communications 14, no. 6 (June 2019): 1934578X1985854. http://dx.doi.org/10.1177/1934578x19858542.

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Abstract:

Acantholippia salsoloides (Verbenaceae) is an aromatic plant widespread in the Andean region. The infusion (leaves and flowers) is widely used as a digestive stimulant as well as for the treatment of various diseases in traditional medicine. A. salsoloides attributes its common name “rica-rica” to the fresh and sweet fragrance of the plant. In this work, 2 different polar extracts and the essential oil of a selected rica-rica population were studied. The phenolic composition was analyzed by high-performance liquid chromatography diode array detector; the essential oil profile was determined by gas-chromatography ion-trap mass spectrometry/flame ionization detection. For all extracts, the antibacterial potential was performed by in vitro assays; the antioxidant and α-glucosidase inhibition were determined in decoction and hydroethanolic extracts. The volatile profile allowed the identification of 26 volatile compounds, β-thujone (84%) being the major one in this rica-rica population. Eighteen phenolic compounds were identified; isoferulic acid (16%-18%) and cynaroside (45%-47%) were the larger ones. In a general way, the hydroethanolic extract was more active against Staphylococcus aureus and Micrococcus luteus (minimum inhibitory concentrations= 0.3- 1.3 mg/mL). Both polar extracts have strong antiradical activities although decoction extract proved to be more active against DPPH· (half-maximal inhibitory concentration [IC50] =36 µg/mL) and O2•− (IC50 =28 µg/mL) while hydroethanolic extract shows higher action over α-glucosidase (IC50 =217 µg/mL). The results suggest that A. salsoloides leaves and flowers may be an interesting source of natural antioxidants, antidiabetics, or antimicrobials, and could be used in dietary supplements, medicinal products and pharmaceutical formulations.

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Giner, Rosa María, María Jesús Cuellar, María Carmen Recio, Salvador Máñez, and José Luis Ríos. "Chemical Constituents of Urospermum picroides." Zeitschrift für Naturforschung C 47, no. 7-8 (August 1, 1992): 531–34. http://dx.doi.org/10.1515/znc-1992-7-807.

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Seven phenolic compounds were isolated from the aerial parts of U. picroides. They were identified by UV spectra, TLC and HPLC-DAD as luteolin, luteolin-7-glucoside, quercetin, quercetin-3-galactoside, kaempferol-3-galactoside, chlorogenic and isochlorogenic acids. Other phenolics were characterized by HPLC-DAD analysis: gallic, protocatechuic, caffeic, ferulic and isoferulic acids, quercetin-3-glucoside and luteolin-4′-glucoside.

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Borges, M. Fernanda M., Fernanda M. F. Roleira, and Madalena M. M. Pinto. "Simultaneous Isocratic HPLC Separation of the Diastereoisomers of Caffeic, Ferulic, and Isoferulic Acids and Related Coumarins." Journal of Liquid Chromatography 16, no. 1 (January 1993): 149–60. http://dx.doi.org/10.1080/10826079308020903.

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Journal articles on the topic 'Isoferulic acid'

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