Academic literature on the topic 'Isochromanes'

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Journal articles on the topic "Isochromanes"

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Dyachenko, V. I., and V. V. Semenov. "A new approach to isochromanes." Russian Chemical Bulletin 59, no. 4 (April 2010): 870–71. http://dx.doi.org/10.1007/s11172-010-0178-0.

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Saikia, Anil K., Sabera Sultana, Ngangbam Renubala Devi, Manash J. Deka, Kartikeya Tiwari, and Vikash K. Dubey. "Diastereoselective synthesis of substituted hexahydrobenzo[de]isochromanes and evaluation of their antileishmanial activity." Organic & Biomolecular Chemistry 14, no. 3 (2016): 970–79. http://dx.doi.org/10.1039/c5ob02038g.

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Dyachenko, V. I., and V. V. Semenov. "ChemInform Abstract: A New Approach to Isochromanes." ChemInform 42, no. 11 (February 17, 2011): no. http://dx.doi.org/10.1002/chin.201111160.

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Kuramochi, Kouji, Kazunori Tsubaki, Isoko Kuriyama, Yoshiyuki Mizushina, Hiromi Yoshida, Toshifumi Takeuchi, Shinji Kamisuki, Fumio Sugawara, and Susumu Kobayashi. "Synthesis, Structure, and Cytotoxicity Studies of Some Fungal Isochromanes." Journal of Natural Products 76, no. 9 (September 13, 2013): 1737–45. http://dx.doi.org/10.1021/np400460m.

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Pihlaja, K., J. Mattinen, E. Kleinpeter, R. Meusinger, Ch Duscheck, and R. Borsdorf. "A1H and13C NMR conformational study of methyl-substituted isochromanes." Magnetic Resonance in Chemistry 23, no. 9 (September 1985): 754–58. http://dx.doi.org/10.1002/mrc.1260230915.

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Li, Xiao-Hua, Xue-Hua Han, Ling-Ling Qin, Jun-Lin He, Zhi-Xing Cao, Yu-Cheng Gu, Da-Le Guo, and Yun Deng. "Isochromanes from Aspergillus fumigatus, an endophytic fungus from Cordyceps sinensis." Natural Product Research 33, no. 13 (May 24, 2018): 1870–75. http://dx.doi.org/10.1080/14786419.2018.1478824.

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Yue, Guizhou, Sicheng Li, Dan Jiang, Gang Ding, Juhua Feng, Huabao Chen, Chunping Yang, et al. "Syntheses of 3,3-Disubstituted Dihydrobenzofurans, Indolines, Indolinones and Isochromanes by Palladium-Catalyzed Tandem Reaction Using Pd(PPh3)2Cl2/(±)-BINAP as a Catalytic System." Catalysts 10, no. 9 (September 18, 2020): 1084. http://dx.doi.org/10.3390/catal10091084.

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A general procedure for the tandem arylation reaction of arylbromide with heteroaryl compounds was developed by using Pd(PPh3)2Cl2/(±)-BINAP (1,1′-Binaphthalene-2,2′-diylbis (diphenylphosphane)) as catalytic system. Both sulphur- and oxygen-containing heterocycles were also employed as an efficient reagent for arylation, which gave moderate to excellent yields with moderate to good regioselectivities (5:1 to > 20:1 ir (isomer ratio)). Except for dihydrobenzofurans, indolines and indolinones, this type of tandem reaction was also expanded to synthesize isochromanes. The synthesized new compounds were well characterized through different spectroscopic techniques, such as 1H and 13C NMR (nuclear magnetic resonance), and mass spectral analysis.
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Hashmi, A. Stephen K, M. Wölfle, Filiz Ata, Melissa Hamzic, Ralph Salathé, and Wolfgang Frey. "Gold Catalysis: Dihydroisobenzofurans and Isochromanes by the Intramolecular Furan/Alkyne Reaction." Advanced Synthesis & Catalysis 348, no. 16-17 (November 2006): 2501–8. http://dx.doi.org/10.1002/adsc.200600367.

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Guyard, Anne-Laure, Alain Valleix, Bernard Rousseau, and Jean-Christophe Cintrat. "Synthesis and deuterium labeling of some 4-phenyl, 3-substituted isochromanes." Journal of Labelled Compounds and Radiopharmaceuticals 44, no. 7 (2001): 529–39. http://dx.doi.org/10.1002/jlcr.484.

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Salomone, Antonio, Filippo Maria Perna, Francesca Claudia Sassone, Aurelia Falcicchio, Jure Bezenšek, Jurij Svete, Branko Stanovnik, Saverio Florio, and Vito Capriati. "Preparation of Polysubstituted Isochromanes by Addition of ortho-Lithiated Aryloxiranes to Enaminones." Journal of Organic Chemistry 78, no. 21 (October 24, 2013): 11059–65. http://dx.doi.org/10.1021/jo401689e.

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Dissertations / Theses on the topic "Isochromanes"

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Muller, Cyprien. "Supramolecular catalysis and vibrational strong coupling : how to influence chemical reactivity ?" Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAF014.

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Comment peut-on influencer la réactivité chimique ? Dans ce travail de thèse, j’ai tâché de répondre à cette question en explorant la frontière entre la chimie et la physique. Dans un premier temps, en tirant avantage du solvant 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) qui permet souvent une réactivité exotique, qui peut être attribuée à ses exceptionnelles propriétés physiques. Ces dernières font de HFIP une véritable matrice supramoléculaire, qui nous a permis le développement d’une nouvelle méthode pour la synthèse d’isochromanes fonctionnalisés. Ce faisant, une généralité et une simplicité opératoire inédites pour la synthèse de ce motif important furent atteintes. Dans un second temps, j’ai exploré la capacité de l’hybridation lumière-matière, accessible grâce au couplage fort vibrationnel (CFV) de modifier la cinétique de certaines réactions chimiques. Ainsi, en plaçant entre deux miroirs différents réactifs, j’ai étudié l’impact du CFV sur la nucléophilicité ainsi que sur la réactivité Diels-Alder
How can we influence chemical reactivity? Throughout this thesis, I attempted to answer this question by exploring the frontier between chemistry and physics.First, I took advantage of solvent 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) which often unlocks exotic reactivity that can be explained by its extraordinary physical properties. These properties make of HFIP a veritable supramolecular matrix, which allowed the development of a new method for the synthesis of densely functionalized isochromans. This method displayed unprecedented generality, simplicity, and practicality on the way to this pharmacologically important motif.Second, I investigated how light-matter hybridization, accessed through Vibrational Strong Coupling (VSC) could alter the kinetics of some chemical reactions. In practice, by placing different reactants between two mirrors, I studied the impact of VSC on nucleophilicity, as well as on Diels-Alder reactivity
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Joll, Cynthia Ann. "The asymmetric synthesis of isochromans related to the aphid pigments." Thesis, Joll, Cynthia Ann (1995) The asymmetric synthesis of isochromans related to the aphid pigments. PhD thesis, Murdoch University, 1995. https://researchrepository.murdoch.edu.au/id/eprint/51655/.

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Many of the naturally occurring benzoisochromanquinones exhibit notable biological activity, being potential antibiotics or antineoplastic agents. The synthetic work described in this thesis is directed towards the asymmetric synthesis of Quinone A 2, Quinone A 3 and Deoxyquinone A 4, three derivatives of the naturally occurring benzoisochromanquinone aphid pigments, protoaphin-fb, protoaphin-sl and deoxyprotoaphin, respectively. In the first chapter, a comprehensive review of a category of benzoisochromanquinone natural products related to the aphid pigment derivatives is presented, highlighting their structures, occurrence and biological activities. This is followed by a discussion of the isolation and structural elucidation of the aphid pigments themselves. The racemic synthesis of the aphid pigment derivatives 2, 3 and 4, and the asymmetric syntheses of several related naturally occurring benzoisochromanquinones are reviewed in the latter part of the chapter. An approach to the first chiral synthesis of Quinone A 2, Quinone A' 3 and Deoxyquinone A 4, through a key intermolecular reaction between a metal phenolate and a chiral aldehyde, is detailed in Chapter Two. It was first necessary to prepare an aromatic compound which is a suitable precursor to the benzyne 189. The assembly of two different precursors is described, and the yields of their respective conversions to the intermediate benzyne 189 and in situ cycloaddition reaction with 2-methoxyfuran compared. Model studies of the key intermolecular reaction, using 4,5,7-trimethoxynaphthalene-1-ol and the 1-ethoxyethyl ether of (2S)-2-hydroxypropanal, are then presented. This reaction was highly diastereoselective and this was controlled by the choice of the metal. Thus, the product of addition of the titanium phenolate differed from that of the magnesium phenolate only at the newly created chiral centre. Chapter Three deals with the application of the reaction between metal phenolates and chiral aldehydes to intramolecular processes. Firstly, commercially available 2,5-dihydroxyacetophenone was transformed into the differentially protected 5-benzyloxy-2-methoxyacetophenone. This was followed by extension of the side chain by formation of an ether with (S)-ethyl lactate. Ultimately, two diastereomeric optically-pure phenols, each bearing an aldehydic side chain derived from (S)-ethyl lactate, were prepared. These were each treated separately with both titanium tetraisopropoxide and ethyl magnesium bromide and the products of the four reactions examined in detail. In the case of the bromomagnesium phenolates, the yields of cyclized products were poor, and for one of these diastereomeric phenolates the stereoselectivity of cyclization was only average. For the titanium phenolates, high yields of products of intramolecular cyclization were obtained. The diastereoselectivity of the cyclization reaction was only 3:1 in one case, but in the other, which produced the required benzopyran analogous to Quinone A, the cyclization was completely diastereoselective. Thus, the first chiral synthesis of a benzopyranquinone having the same absolute stereochemistry as the enantiomer of Quinone A, i.e., quinone 234, is presented.
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Majeed, Amera Jihad. "Electrochemical oxidation of isochromanones, isoquinolines and related structures." Thesis, University of Bath, 1986. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332114.

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Vetica, Fabrizio [Verfasser]. "Organocatalytic Asymmetric Synthesis of Isochromanones, Tetranortriterpenoids and Pyrazolone Derivatives / Fabrizio Vetica." München : Verlag Dr. Hut, 2018. http://d-nb.info/1155056213/34.

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Fronert, Jeanne Katrin [Verfasser]. "Organokatalytische asymmetrische Synthesen von Dihydrobenzofuranen und Isochroman-1-onen / Jeanne Katrin Fronert." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2015. http://d-nb.info/1080490825/34.

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Coelho, Paulo. "Etude de la diastereoselectivite des reactions intramoleculaires de composes presentant un atome de silicium chiral. Synthese de derives de 4-silatetrahydro-isochroman-1-ones, de 4-sila-2h-isoquinolein-1-ones et de silacycloalcanes." Paris 11, 1995. http://www.theses.fr/1995PA112069.

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Divers silatrienes et alcenyl(bromomethyl)silanes presentant un atome de silicium chiral ont ete synthetises en 4 a 6 etapes a partir de chlorosilanes commerciaux avec des rendements satisfaisants afin d'etudier la selectivite de reactions de diels-alder intramoleculaires et de cyclisations radicalaires intramoleculaires. Des 4-sila-4a,7,8,8a-tetrahydroisochroman-1-ones et des 4-sila-3,4,4a,7,8,8a-hexahydro-2h-isoquinolein-1-ones ont ete preparees diastereoselectivement par reaction de diels-alder intramoleculaire des acrylates, methacrylates et monomethylfumarates de 2-methyl-2-silahexa-3,5-dienyle et des n-benzyl-n-(buta-1,3-dienylsilylmethyl)acrylamides. C'est la cycloaddition de l'acrylate de 2-(2-methoxyphenyl)-2-methyl-2-silahexa-3,5-dienyle catalysee par etalcl#2 a temperature ambiante qui presente la meilleure selectivite: l'un des diastereoisomeres constitue 90% du melange des quatre silatetrahydroisochromanones isole avec un rendement de 74%. Des 4-sila-3,4,4a,5-tetrahydro-2h-isoquinolein-1-ones ont ete preparees diastereoselectivement par reaction de diels-alder a demande electronique inverse des n-benzyl-n-(vinylsilylmethyl)-2-pyranone-6-carboxamides, suivie d'elimination de co#2 par reaction de retro diels-alder. La meilleure selectivite (rapport des diastereoisomeres: 80/20) a ete obtenue avec le compose presentant les groupes cyclohexyle et methyle sur l'atome de silicium. La 4-cyclohexyl-4-methyl-4-sila-3,4,4a,5,6,8a-hexahydro-2h-isoquinolein-1-one-6,8a-carbolactone intermediaire dans cette reaction a pu etre isolee. Le traitement des alcenyl(bromomethyl)silanes par l'hydrure de tributyletain permet de preparer selectivement et avec de bons rendements des silacyclopentanes, des silacyclohexanes et des silacycloheptanes
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Govender, Sameshnee. "Methodology for the Enantioselective Synthesis of Isochromanes and their Dimers." Thesis, 2006. http://hdl.handle.net/10539/1713.

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Faculty of Science School of Chemistry 9800165e govendor@aurum.wits.ac.za
Pyranonaphthoquinones are biologically important molecules found in a wide variety of bacteria, microbial fungi and plant species. Their biological activity is proposed to be a consequence of their ability to function as bioreductive alkylating agents. This class of compounds, which include monomeric and dimeric examples, contain the basic naphtho[2,3-c]pyran-5,10-dione skeleton, usually with substituents at the C-1 and C-3 positions of the pyran ring. The aim of the first part of the project was to develop a novel method for the synthesis of enantiomerically pure 5,8-dimethoxy-isochroman-4-ol, which will provide a handle for stereoselectively adding substituents to the C-1 and C-3 positions of the pyran nucleus. In the second part of the project we wished to attempt to synthesize the naturally occurring compound, cardinalin 3, the dimer of ventiloquinone L previously synthesized in the Wits laboratories. The synthesis of the enantiomerically pure isochromanol began with 2,5-dihydroxybenzoic acid, which was subjected to a diallylation followed by a Claisen rearrangement. The phenols were protected by a methylation reaction and the ester moiety was reduced to give (2-allyl-3,6- dimethoxyphenyl)methanol. It was then allylated to produce a suitable precursor for a one pot/two step ruthenium mediated isomerisation/ring closing metathesis reaction to produce 5,8-dimethoxy-1H-isochromene in an overall yield of 47%. It was converted to racemic 5,8-dimethoxy-isochroman-4-ol through a hydroboration-oxidation reaction in a yield of 84%. The separation of the enantiomers was achieved by acetylating the alcohol to form 5,8-dimethoxy-3,4-dihydro-1H-isochromen-4-yl acetate and then a lipase enzyme was used to stereospecifically deacetylate one enantiomer, while leaving the other enantiomer untouched. The second part of the dissertation discusses the progress towards the synthesis of cardinalin 3. This project began with the formation of the C-C biaryl axis starting from 1,3-dimethoxybenzene. The synthesis then continued with the diformylation of the biphenyl to give 2,2’,6,6’-tetramethoxy[1,1′-biphenyl]-3,3′-dicarbaldehyde. This was subjected to a Stobbe condensation and a Friedel-Crafts acylative cyclisation to produce diethyl [4,4′-diacetoxy-6,6′,8,8′-tetramethoxy-7,7′-binaphthalene]-2,2′- dicarboxylate. The synthesis will be continued in the PhD, using methodology previously developed for the formation of the monomer, as well as methodology developed here.
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Karapetyan, Vahuni [Verfasser]. "Synthesis of bridged and non-bridged N-heterocycles, dichloromethyl- and formyl-salicylates, pyran-4-ones, chromanes and isochromanes based on cyclocondensation reactions of 1,3-bis(silyloxy)-1,3-butadienes and oxime dianions / vorgelegt von Vahuni Karapetyan." 2009. http://d-nb.info/1001599659/34.

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Senanayake, Badra Sriyani. "Approaches to natural isochromans by isomerisation of aryldioxolanes." Phd thesis, 1992. http://hdl.handle.net/1885/138963.

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Wei-Hsiang, Hung, and 洪偉翔. "A Synthesis of Isochromans Via Claisen Rearrangement and Intramolecular Cyclization." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/95048723709620156052.

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碩士
高雄醫學大學
藥學研究所碩士在職專班
92
英文摘要 In this study, 2-allyloxyisovanillin ( 2 ), prepared from isovanillin ( 1 ), was heated at higher temperature ( 180 ℃) to undergo the Claisen rearrangement to furnish 2-allyl-3-hydroxy-4-methoxybenzaldehyde ( 3 ). Based on O-alkylation and reduction ,compound 3 was converted into 3-alkyloxy-2-allyl-4-methoxybenzyl alcohol ( 5 ) in good yields. Followed by the treatment of compound 5 with potassium tert-butoxide to undergo the isomerization of the allylic double bond, and concomitantly to undergo the sp2-endo trigonal intramolecular cyclization, gave a series of new substituted isochromans in moderate yields.
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Book chapters on the topic "Isochromanes"

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Lavine, Barry K., and Collin White. "Odor-Structure Relationship Studies of Indan, Tetralin, and Isochroman Musks." In ACS Symposium Series, 333–59. Washington, DC: American Chemical Society, 2015. http://dx.doi.org/10.1021/bk-2015-1191.ch023.

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Fauszt, I., A. Fehér, Gy Horváth, A. Juhász, E. Széll, and S. Bajusz. "Facile synthesis of 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid, a constrained phenylglycine and its oxa analog, isochromane-1-carboxylic acid." In Peptides 1994, 678–79. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-1468-4_311.

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"Olive Oil Hydroxy-Isochromans." In Olive Oil, 207–14. CRC Press, 2008. http://dx.doi.org/10.1201/9781420059946-13.

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Guiso, Marcella, Giuliana Trefiletti, and Giuseppina Togna. "Olive Oil Hydroxy-Isochromans." In Olive Oil, 193–200. CRC Press, 2008. http://dx.doi.org/10.1201/9781420059946.ch9.

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Freeman, R. "Spin choreography." In Pulsed Magnetic Resonance: NMR, ESR, and Optics, 219–41. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780198539629.003.0010.

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Abstract Very soon after the initial discovery of nuclear magnetic resonance, E. L. Hahn performed an experiment that, in conceptual originality and elegance, transcended all that had preceded it-the spin echo experiment [1]. Here was an idea to inspire the young scientists reading about NMR for the first time. Not only could oneworkwith these strange new entities called spins, but alsomanipulatethem like a conjuror with a pack of cards. In its original form, experiment was conceptually easier to follow, resembling the opening and closing of a ‘fan’ of vectors confined to the transverse(x-y)plane of the rotating frame. Note that the description of the conventional continuous wave NMR experiments of the time scarcely required this level of sophistication, relying on the steady state solutions of the Bloch equations. To understand spin echoes, one was forced to come to grips with homogeneous and inhomogeneous line broadening, transformation into the rotating frame of reference, and the concept of ‘spin isochromats’. This was a term coined by Abragam [3]. The sample is considered to be made up of a mosaic of volume elements, each small enough that the variation of the applied field intensity across that element could be neglected, but with neighbouring elements in slightly different applied fields due to the spatial inhomogeneity. Each element has a nuclear magnetization with a characteristic precession frequency; this is an isochromat. The total sample magnetization is the resultant of all these isochromatic magnetization vectors. Because the isochromats have different intrinsic frequencies this resultant can change as individual isochromats fan out or come back into alignment. This has proved a valuable idea for describing spin echo experiments.
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Nógrádi, M. "By Oxidative Fragmentation of 1-2-Benzopyrans (Isochromans)." In Six-Membered Hetarenes with One Chalcogen, 1. Georg Thieme Verlag KG, 2003. http://dx.doi.org/10.1055/sos-sd-014-00146.

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Menche, D. "Stereoselective Synthesis of Isochromanones with and Without Activated Spin Intermediates." In Strategies and Tactics in Organic Synthesis, 193–213. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-08-100756-3.00007-8.

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Conference papers on the topic "Isochromanes"

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C.T., Samlan, Dinesh N. Naik, and Nirmal K. Viswanathan. "Separating Isogyres and Isochromates of a Uniaxial Crystal using Fourier Fringe Analysis." In International Conference on Fibre Optics and Photonics. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/photonics.2016.th3a.4.

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