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Dissertations / Theses on the topic 'Islands of Langerhans'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

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1

Ar'Rajab, Aamer. "Islet transplantation in the treatment of diabetes number of islets, functional regulation and metabolic control /." Lund : Dept. of Surgery, Lund University, 1991. http://catalog.hathitrust.org/api/volumes/oclc/38187937.html.

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2

Axcrona, Ulrika Myrsén. "Expression and regulation of neuropeptide Y (NPY) in the Islets of Langerhans." Lund : Dept. of Physiology and Neuroscience, Section for Neuroendocrine Cellbiology, Lund University, 1997. http://books.google.com/books?id=Ew5rAAAAMAAJ.

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3

Edwin, Nalini. "Quantitative estimation of islet tissue of pancreas in Australian mammals (comparative histological study) /." Title page, contents and summary only, 1986. http://web4.library.adelaide.edu.au/theses/09PH/09phe269.pdf.

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4

Kulis, Michael D. "Islet neogenesis associated protein-related protein from gene to folded protein /." Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-01112006-195113/.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2006.<br>Shuker, Suzanne, Committee Chair ; Doyle, Donald, Committee Member ; Orville, Allen, Committee Member ; Barry, Bridgette, Committee Member ; McCarty, Nael, Committee Member.
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5

Blais, Debbie Lin Marie. "Becoming an islet cell allotransplant recipient." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq21258.pdf.

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6

Yan, Mengyong. "Interaction of human papillomavirus-like particles with dendritic cells and Langerhans cells : involvement in uptake, activation and cross-presentation /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17614.pdf.

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7

Teague, Warwick J. "Mesenchyme-to-epithelial transition in pancreatic organogenesis." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670115.

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8

Iovino, Giugetta. "The role of lipid peroxidation in pancreatic islet function and destruction in Type 1 diabetes mellitus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ37131.pdf.

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9

Wu, Douglas Ching Gee. "Cellular therapeutic strategies for the treatment of Type 1 Diabetes Mellitus." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670111.

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10

Serra, Navarro Berta. "Implicació de la senyalització dependent de Gsα en l’establiment de la massa cel·lular β". Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/667060.

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La regulación y potenciación de la proliferación de la célula β pancreática es un objetivo principal en la prevención y/o retardo de la diabetes. Su replicación se regula a través de un proceso dinámico, siendo muy elevada en el estado embrionario hasta el nacimiento y disminuyendo gradualmente durante la etapa posnatal, manteniéndose en niveles muy bajos durante la edad adulta. Las vías de señalización que regulan este descenso son poco conocidas. Este estudio pretende establecer el papel de las vías Gsα-dependientes que actúan a través del segundo mensajero AMPc en la regulación de la ma
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11

Wilson, John Tanner. "Biomolecular strategies for cell surface engineering." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/33846.

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Islet transplantation has emerged as a promising cell-based therapy for the treatment of diabetes, but its clinical efficacy remains limited by deleterious host responses that underlie islet destruction. In this dissertation, we describe the assembly of cell surface-supported thin films that confer molecular-level control over the composition and biophysicochemical properties of the islet surface with implications for improving islet engraftment. Specifically, the process of layer-by-layer (LbL) polymer self assembly was employed to generate nanothin films of diverse architecture with tunable
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12

Jackson, Andrew M. Naziruddin Bashoo. "Analysis of inflammatory changes in human pancreatic islet cells." Waco, Tex. : Baylor University, 2009. http://hdl.handle.net/2104/5344.

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13

Alves, Figueiredo Hugo Jorge. "Improving islet-graft revascularization." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/586309.

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El trasplante de islotes ha sido reconocido como una prometedora opción de tratamiento de la diabetes tipo 1 (DT1) tras la introducción del protocolo de Edmonton, el cual enfatiza el requerimiento de un adecuado número de islotes donantes así como el uso de regímenes de inmunosupresores libres de esteroides. Además es un procedimiento quirúrgico menos invasivo y que conlleva menos complicaciones comparado con el trasplante de páncreas. A pesar de los importantes avances establecidos por el protocolo de Edmonton, el uso clínico del trasplante de islotes para el tratamiento de pacientes DT1 cont
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14

Filiputti, Eliane. "Regulação da secreção de insulina em ilhotas de Langerhans de ratos submetidos a restrição proteica e suplementados com leucina." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314197.

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Orientador: Everardo Magalhães Carneiro<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-06T11:23:18Z (GMT). No. of bitstreams: 1 Filiputti_Eliane_D.pdf: 3662221 bytes, checksum: e40ea0446558f8556a8352fd8c98a5fc (MD5) Previous issue date: 2006<br>Resumo: Suspeita-se que a desnutrição intra-uterina e pós-natal produzam mudanças morfológicas e funcionais no pâncreas endócrino e em tecidos periféricos, que se traduzem em insulinopenia e resistência à insulina. Baseado nessas complicações avaliou-se neste trabalho a regulação d
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15

Arantes, Vanessa Cristina. "Acido graxo aumenta a secreção de insulina e modula a expressão de genes envolvidos na biossintese de insulina em ilhotas de ratos submetidos a desnutrição proteica." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313938.

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Orientador: Antonio Carlos Boschero<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-06T07:06:58Z (GMT). No. of bitstreams: 1 Arantes_VanessaCristina_D.pdf: 1696436 bytes, checksum: 2db258b560bf7ee0ec64de7441adfe76 (MD5) Previous issue date: 2006<br>Resumo: Em animais, a desnutrição intra-uterina exerce efeitos marcantes sobre o desenvolvimento fetal e pós-natal. Sabe-se que animais desnutridos apresentam níveis elevados de ácidos graxos plasmáticos e esses, por sua vez, são responsáveis por alterar a secreção de insulina.
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16

Quallio, Silvana. "Avaliação da função e plasticidade celuar de ilhotas pancreaticas em modelo de resistencia a insulina induzida por dexametosa em ratos." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314399.

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Orientador: Jose Roberto Bosqueiro<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-11T17:39:01Z (GMT). No. of bitstreams: 1 Quallio_Silvana_M.pdf: 957537 bytes, checksum: 0c375a9b9290585b85244a414a6ea02d (MD5) Previous issue date: 2008<br>Resumo: Introdução e objetivos: O aumento nos níveis de glicose circulante é o principal estímulo para a secreção de insulina. A insulina se liga a receptores de membrana desencadeando diversas respostas celulares. Qualquer alteração na sensibilidade à insulina pode levar a disfunçõ
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17

Wong, Jeffrey K. W. "Chemokines and chemokine receptors in islet xenograft rejection." Thesis, The University of Sydney, 2006. https://hdl.handle.net/2123/28055.

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This project investigates the role of chemokine and chemokine receptors in a model of CD4 T cell dependent cellular xenograft rejection, specifically the transplantation of fetal pig pancreas tissue to the renal subcapsular space of mice. Chemokines and chemokine receptor gene expression was assessed by cDNA arrays, and confirmed by multi-probe ribonuclease protection assay. Immunostaining for a selected chemokine, RANTES was performed to demonstrate upregulation at the protein level. These methods were applied to several different models to dissect the role Chemokines and their re
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18

Atla, Goutham. "Dissecting genetic regulatory mechanisms in human pancreatic islets to gain insights into type 2 diabetes pathophysiology." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672647.

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Diabetes mellitus is a heterogeneous group of metabolic diseases characterized by impaired blood glucose homeostasis that affects more than 415 million people worldwide and is a leading cause of mortality. The most prevalent form of diabetes is Type 2 Diabetes (T2D) that accounts for 90% of diabetes cases. An interplay of environmental and genetic risk factors contributes to etiology of T2D via a progressive loss of pancreatic beta cell function coupled with insulin resistance. Genome Wide Association Studies (GWAS) identified more than 400 independent genetic loci associated with T2D risk, al
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19

Phelps, Edward Allen. "Bio-functionalized peg-maleimide hydrogel for vascularization of transplanted pancreatic islets." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45899.

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Type 1 diabetes affects one in every 400-600 children and adolescents in the US. Standard therapy with exogenous insulin is burdensome, associated with a significant risk of dangerous hypoglycemia, and only partially efficacious in preventing the long term complications of diabetes. Pancreatic islet transplantation has emerged as a promising therapy for type 1 diabetes. However, this cell-based therapy is significantly limited by inadequate islet supply (more than one donor pancreas is needed per recipient), instant blood-mediated inflammatory reaction, and loss of islet viability/function dur
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20

Ribeiro, Rosane Aparecida. "Regulação da secreção de insulina em ilhotas pancreaticas de camundongos suplementados com taurina." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314748.

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Orientador: Everardo Magalhães Carneiro<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-13T09:09:25Z (GMT). No. of bitstreams: 1 Ribeiro_RosaneAparecida_D.pdf: 2339564 bytes, checksum: 146ea5a2123d76628db5f4758417e020 (MD5) Previous issue date: 2009<br>Resumo: Neste estudo, investigamos os efeitos da suplementação com taurina (TAU; 2% adicionada à água de beber) sobre a tolerância à glicose e a secreção de insulina frente a diferentes secretagogos em camundongos adultos. Camundongos suplementados apresentaram aumento da to
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21

Wang, Xiao Yang. "Approaches to induce islet allograft tolerance by liver allografting and to improve fetal pig islet function by gut hormones." Thesis, The University of Sydney, 1999. https://hdl.handle.net/2123/27740.

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This thesis examined (1) the effect of liver transplantation on tolerance induction to islet allografts; (2) the effects of gut hormones (CCK, GLP-1) on fetal pig islets. Liver allografts in tolerant strain combinations are unique in their ability to induce tolerance to other organ and skin grafts from the same donor strain in the absence of immunosuppression. Whether liver transplantation has the same effect on islet allografts is unknown. Studies in this thesis demonstrate that the protective effect of liver transplantation on islet allografts varies with the time of liver grafting. Islet
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22

Cadavez, Trigo Lisa. "Islet amylold in type 2 diabetes: The role of chaperones in endoplasmic reticulum stress and amyloid formation in pancreatic β-cell". Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/290734.

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La disminución de la masa de célula ß pancreática y la función en la diabetes tipo 2 (T2D) se puede atribuir a una serie de factores estresantes experimentados por el islote durante el desarrollo y la progresión de la enfermedad, incluyendo el amiloide de los islotes. El amiloide de los islotes pancreáticos se compone predominantemente del péptido humano amilina, también conocido como polipeptido amiloide del islote humano (hIAPP). Estos depósitos están implicados en el proceso de deterioro de las células ß y en la reducción de la masa celular ß e implica la agregación de monómeros solubles no
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23

Velasco, Mallorquí Ferran. "Carboxymethyl cellulose-based cryogels as scaffolds for pancreatic and skeletal muscle tissue engineering." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672378.

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Diabetes incidence highly increased in the last years. According to IDF (International Diabetes Federation), 463 million people suffered this disease in 2019. The estimations of diabetic people highly increase in the upcoming years, rising approximately to 700 million diabetic patients in 2045 [1]. Type 2 diabetes (T2D) is the most common type of diabetes, representing 90% of diabetic patients. It occurs when the body becomes resistant to insulin. Body insulin resistance confirms that T2D is not only a pancreatic disease, as there are many other tissues involved, like liver, adipose tissue, o
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24

Roma, Leticia Prates. "Analise da expressão genica e proteica de ilhotas de ratos tratados com dexametasona." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314401.

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Orientador: Jose Roberto Bosqueiro<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-06T10:10:15Z (GMT). No. of bitstreams: 1 Roma_LeticiaPrates_M.pdf: 861159 bytes, checksum: 232359e1de6e654ce6bb13758ca58bd2 (MD5) Previous issue date: 2006<br>Resumo: As células B pancreáticas possuem controle multifatorial que permite a secreção de insulina em quantidade e tempo adequados. Os glicocorticóides modulam a secreção de insulina dependendo do tempo e dose em que forem utilzados. Assim,o presente trabalho teve por objetivo a
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25

Silva, Kelly Elizeu da. "INGAP-PP (Islets Neogenesis Associated Protein) aumenta a expressao das proteinas do canal de potassio, sensivel ao ATP, em ilhotas cultivadas de ratos adultos." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313923.

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Orientador: Antonio Carlos Boschiero<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-09T03:49:57Z (GMT). No. of bitstreams: 1 Silva_KellyElizeuda_M.pdf: 1866524 bytes, checksum: 87ae185f2da61d551d322f4375943e54 (MD5) Previous issue date: 2007<br>Resumo: O INGAP-PP é um pentadecapeptídeo constituído pela seqüência de aminoácidos do resíduo 104 ao 118 do INGAP (Islet Neogenesis Associated Protein), o qual é expresso no pâncreas exócrino e também nas células ductais durante a neogênese de células ßpancreáticas. Nesse tr
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Stoppiglia, Luiz Fabrizio. "Modulação dos mecanismo de defesa das ilhotas pancreaticas contra o estresse oxidativo." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313936.

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Orientador: Antonio Carlos Boschero<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-06T10:55:45Z (GMT). No. of bitstreams: 1 Stoppiglia_LuizFabrizio_D.pdf: 2405428 bytes, checksum: 6387a533bea2ca65f3826092e2220b39 (MD5) Previous issue date: 2006<br>Resumo: No diabetes mellitus, radicais de oxigênio estão associados com perda de sensibilidade à glicose ou destruição das células b. Nesse trabalho, investigamos a tolerância de ilhotas de Langerhans de ratos neonatos ao estresse provocado por H2O2, seus mecanismos antioxidante
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27

Giozzet, Vanessa Aparecida Gonçalves. "Analise das ações da dexametasona sobre a secreção de insulina, parametros bioquimicos e moleculares em ratos submetidos a restrição proteica." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314400.

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Orientador: Jose Roberto Bosqueiro<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-10T23:23:58Z (GMT). No. of bitstreams: 1 Giozzet_VanessaAparecidaGoncalves_D.pdf: 2125921 bytes, checksum: 5e1d4923fcc0268442cc60af14fa58dd (MD5) Previous issue date: 2008<br>Resumo: A desnutrição e a resistência periférica à insulina induzida por administração de glicocorticóides induzem compensações funcionais e morfológicas em ilhotas pan creáticas a fim de manter a homeostase glicêmica. Deste modo, investigamos as alterações desenvolvida
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28

Barthson, Jenny. "Transcription factors and downstream genes modulating TNF-gas + IFN-gcs induced beta cell apoptosis." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209491.

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In type 1 diabetes (T1D) a combination of genetic predisposition and environmental factors triggers islet inflammation (insulitis) leading to a selective and gradual destruction of the pancreatic beta cells. Beta cells mainly die through apoptosis, triggered at least in part by pro-inflammatory cytokines such as IL-1β, TNF-α and IFN-γ. Recent findings suggest that the mitochondrial pathway of cell death is involved in this death cascade. Array analysis indicated that TNF-α+IFN-γ induces transcription factors such as NF-ĸB, STAT1, and AP-1 in beta cells. We presently aimed to examine the pathwa
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29

Gregg, Randal K. "Mechanisms underlying diabetogenesis in the NOD mouse." Free to MU campus, others may purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3115548.

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Batista, Thiago Martins 1984. "Modulação do mecanismo de sedreção de insulina em ilhotas pancreaticas de ratos submetidos a restrição protetica e suplementados com taurina." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314196.

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Orientador: Everardo Magalhães Carneiro<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-13T21:03:55Z (GMT). No. of bitstreams: 1 Batista_ThiagoMartins_M.pdf: 1168177 bytes, checksum: 6c327ab4c396fab9844364b47f69ad79 (MD5) Previous issue date: 2009<br>Resumo: A desnutrição ainda é um problema de saúde pública que afeta principalmente países em desenvolvimento e sua prevalência chega a ser crescente em algumas áreas. Vários estudos obtiveram êxito em correlacionar a má nutrição em estágios iniciais de vida com o desenv
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Vanzela, Emerielle Cristine 1982. "Dieta de cafeteria induz obesidade, resistência periférica a insulina, e reduz a secreção deste hormônio por ilhotas de ratas = restauração do processo secretório, mas não da sensibilidade à insulina durante a prenhez." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313918.

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Orientador: Antonio Carlos Boschero<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-16T00:11:07Z (GMT). No. of bitstreams: 1 Vanzela_EmerielleCristine_D.pdf: 2535043 bytes, checksum: eee7b54cea5f470c5637de8c4b3385f5 (MD5) Previous issue date: 2010<br>Resumo: A obesidade atingiu proporções alarmantes constituindo-se num fator de risco para o desenvolvimento de várias doenças. O aumento da resistência periférica à insulina acompanha esta patologia e a incapacidade da célula beta pancreática em suprir a maior necessidade por
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Purificação, Thais Almeida 1980. "Participação das proteínas AS160 e Rab27A na secreção de insulina de ratos controles e insulino-resistentes por dexametasona." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313950.

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Orientadores: Antonio Carlos Boschiero, Alex Rafacho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-20T10:53:44Z (GMT). No. of bitstreams: 1 Purificacao_ThaisAlmeida_M.pdf: 1255549 bytes, checksum: 5142cacf6ca932aa0dd1a86b9eef5074 (MD5) Previous issue date: 2012<br>Resumo: Administração de glicocorticóides em roedores e humanos aumenta a resistência à insulina (RI). A RI, provocada por dexametasona, leva a hiperinsulinemia por aumento da secreção do hormônio pelas ilhotas pancreáticas. Recentemente, demonstrou-se qu
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Estil·les, Altimiras Elisabet. "Efectes de la sobreexpressió d’IGF2 en la protecció i la regeneració de les cèl·lules beta pancreàtiques." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/285812.

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Un aspecte central, tant en el desenvolupament de la diabetis tipus 1 com en el de la tipus 2, és la reducció del nombre de cèl·lules beta productores d’insulina, i en ambdues condicions la pèrdua de massa beta s’ha atribuït en gran mesura a l’augment de la mort de les cèl·lules beta. A més, diversos treballs han posat de relleu la contribució fonamental de la replicació de les cèl·lules beta pel manteniment fisiològic i la regeneració de la massa de cèl·lules beta en models amb massa beta reduïda, la qual cosa pot suggerir que l’alteració de la replicació de les cèl·lules beta també pot contr
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34

Violato, Natalia Moretti [UNESP]. "Avaliação do estado inflamatório em ilhotas de Langerhans de camundongos portadores do tumor sólido de Ehrlich." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/87801.

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Made available in DSpace on 2014-06-11T19:23:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-02-26Bitstream added on 2014-06-13T19:49:32Z : No. of bitstreams: 1 000750938.pdf: 1775034 bytes, checksum: c641a43dad9d97c0e823027882ca517f (MD5)<br>A manutenção da homeostase energética é, sem duvida, o aspecto fisiológico mais importante para a garantia de sobrevivência animal. Doenças crônicas como câncer são capazes de alterar esta homeostase, agravada principalmente pela presença do tumor. O conjunto de sintomas envolvidos neste quadro de desequilíbrio metabólico, comum a diversas doe
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Violato, Natalia Moretti. "Avaliação do estado inflamatório em ilhotas de Langerhans de camundongos portadores do tumor sólido de Ehrlich /." Botucatu, 2013. http://hdl.handle.net/11449/87801.

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Orientador: José Roberto Bosqueiro<br>Banca: José Maurício Sforcin<br>Banca: Silvana Bordin<br>Resumo: A manutenção da homeostase energética é, sem duvida, o aspecto fisiológico mais importante para a garantia de sobrevivência animal. Doenças crônicas como câncer são capazes de alterar esta homeostase, agravada principalmente pela presença do tumor. O conjunto de sintomas envolvidos neste quadro de desequilíbrio metabólico, comum a diversas doenças, foi agrupado e caracterizado como uma síndrome metabólica denominada caquexia que, entre outros fatores, leva à progressiva perda de peso, perda d
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36

Wang, Sui. "The Myt1 and Ngn3 feed-forward expression loop drives pancreatic islet differentiation in the mouse." Diss., 2009. http://etd.library.vanderbilt.edu/available/etd-11262009-124114/.

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37

Li, Xiaoyan. "Metallothionein overexpression prolongs grafts survival in the early phase of pancreatic islet transplantation." 2002. http://etd.louisville.edu/data/UofL0015t2002.pdf.

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38

"Pancreatic islet renin-angiotensin system: its role in insulin secretion and in islet transplantation." 2004. http://library.cuhk.edu.hk/record=b5892115.

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Lau Tung.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (leaves 142-157).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>摘要 --- p.iii<br>Acknowledgements --- p.v<br>Table of Contents --- p.vi<br>List of Abreviations --- p.x<br>Chapter Chapter 1 --- Introduction<br>Chapter 1.1 --- Pancreas and its functions --- p.1<br>Chapter 1.1.1 --- Structure of pancreas --- p.1<br>Chapter 1.1.2 --- Exocrine function --- p.4<br>Chapter 1.1.3 --- Endocrine function --- p.7<br>Chapter 1.1.3.1 --- Pancreatic islet and islet cells --- p.
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39

Ramji, Qahir Alnasir. "Co-transplantation of neonatal porcine islets with Sertoli cells combined with short-term monoclonal antibody therapy in preventing neonatal porcine islet xenograft rejection." 2009. http://hdl.handle.net/10048/461.

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Thesis (M.Sc.)--University of Alberta, 2009.<br>A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science in Experimental Surgery, Department of Surgery, University of Alberta. Title from pdf file main screen (viewed on July 28, 2009). Includes bibliographical references.
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40

Li, Xiaoyan. "The roles of pancreatic beta cell antioxidants in islet transplantation and type 1 diabetes." 2004. http://etd.louisville.edu/data/UofL0054d2004.pdf.

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41

"The effects of neuroendocrine factors on islet cell gene expression." 1996. http://library.cuhk.edu.hk/record=b5889162.

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by Hinny Shuk-Yee Lam.<br>Year shown on spine: 1997.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1996.<br>Includes bibliographical references (leaves 92-117).<br>Declaration --- p.i<br>Acknowledgements --- p.ii<br>Abstract --- p.iii<br>Table of Contents --- p.v<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Pancreas and Islets of Langerhans --- p.1<br>Chapter 1.1.1 --- Islet Hormones and Glucose Balance --- p.3<br>Chapter 1.1.2 --- Glucagon and Its Derived Peptides --- p.4<br>Chapter A. --- Tissue-specific Post-translational Processing --- p.4<br>Chapter B.
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42

"The modulatory effects of simvastatin, a HMG CoA reductase inhibitor, on insulin release from isolated porcine pancreatic islets of Langerhans." 2010. http://library.cuhk.edu.hk/record=b5894451.

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Wong, Mei Fung.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2010.<br>Includes bibliographical references (leaves 207-251).<br>Abstracts in English and Chinese.<br>ABSTRACT --- p.i<br>摘要 --- p.iv<br>ACKNOWLEDGEMENTS --- p.vi<br>PUBLICATIONS BASED ON WORK IN THIS THESIS --- p.vii<br>ABBREVIATIONS --- p.viii<br>TABLE OF CONTENTS --- p.x<br>Chapter CHAPTER 1 --- INTRODUCTION --- p.1<br>Chapter 1.1 --- Diabetes Mellitus --- p.1<br>Chapter 1.2 --- Structure and Functions of the Pancreas --- p.2<br>Chapter 1.2.1 --- Size of Pancreatic β-Cells --- p.4<br>Chapter 1.2.2 --- Signaling
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43

Millings, Elizabeth Joy. "Investigating the Role of ILDR2 in Hepatic Lipid Metabolism and Pancreas Islet Function." Thesis, 2017. https://doi.org/10.7916/D8NS169R.

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Metabolic syndrome defines a cluster of related comorbidities including obesity, Type 2 diabetes, fatty liver disease, and cardiovascular diseases. Increasingly prevalent in Western countries, metabolic syndrome diseases are a major focus of efforts to understand the complex genetics that underlie disease risk and severity. Immunoglobulin domain-containing receptor 2 (ILDR2) is an ER transmembrane protein first identified as a candidate genetic modifier of diabetes susceptibility in the context of obesity. Obese, leptin-deficient mice with hypomorphic Ildr2 expression had hypoinsulinemic hyper
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44

Singer, Ruth Arielah. "Long noncoding RNAs are critical regulators of pancreatic islet development and function." Thesis, 2019. https://doi.org/10.7916/d8-nnax-mb40.

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Diabetes is a complex group of metabolic disorders with genetic, immunological, and environmental etiologies. Decades of diabetes research have elucidated many genetic drivers of normal islet function and dysfunction. Furthermore, genome wide associated studies (GWAS) have discovered that most diabetes susceptibility loci fall outside of coding regions, which suggests a role for noncoding elements in the development of disease. This highlights our incomplete understanding of the islet regulome and suggests the need for detailed functional analyses of noncoding genes to precisely determine thei
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45

"Studies on some factors critical for the development of pancreatic progenitor cells derived from human fetal pancreas." 2011. http://library.cuhk.edu.hk/record=b5896938.

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Ng, Ka Yan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 179-204).<br>Abstracts in English and Chinese.<br>Abstract --- p.I<br>摘要 --- p.IV<br>Publications --- p.VII<br>Acknowledgements --- p.VIII<br>Table of contents --- p.IX<br>List of figures --- p.XV<br>List of tables --- p.XVII<br>List of abbreviations --- p.XVIII<br>Chapter Chapter 1 --- General Introduction<br>Chapter 1.1 --- The Pancreas --- p.2<br>Chapter 1.1.1 --- Anatomy of Pancreas --- p.2<br>Chapter 1.1.2 --- The Exocrine Pancreas --- p.4<br>Chapter 1.1.3 ---
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46

"Isolation, characterization and differentiation of pancreatic progenitor cells from human fetal pancreas." Thesis, 2007. http://library.cuhk.edu.hk/record=b6074338.

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Another growth factor candidate is a recently recognized bioactive peptide, islet-neogenesis associated protein (INGAP). A master pancreatic transcription factor, pancreatic duodenal homeobox-1 (Pdx-1), was overexpressed in PSCs by the adenovirus-mediated transfer method in the present study. With the infection of adenovirus expressing Pdx-1, several beta-cell developmental genes, including Isl-1, Beta2, Nkx2.2, Nkx6.1 and the endogenous Pdx-1 were found to be upregulated temporally in our PSCs-derived ICCs. Meanwhile, previous study has shown that Pdx-1/INGAP-positive cells represent a new st
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"Studies on some immune properties of the pancreatic progenitor cells derived from human fetal pancreas." 2010. http://library.cuhk.edu.hk/record=b5894466.

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Ma, Man Ting.<br>"July 2010."<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2010.<br>Includes bibliographical references (leaves 186-207).<br>Abstracts in English and Chinese.<br>Abstract --- p.I<br>List of Publications --- p.VI<br>Acknowledgements --- p.VIII<br>Table of Contents --- p.X<br>List of Figures --- p.XV<br>List of Tables --- p.XVIII<br>List of Abbreviations --- p.XIX<br>Chapter CHAPTER1 --- INTRODUCTION<br>Chapter 1.1 --- The Pancreas --- p.2<br>Chapter 1.1.1 --- Structure of pancreas --- p.2<br>Chapter 1.1.2 --- Structure and function of exocrine pancreas --- p.6
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Dean, Sophia Katrina Prince of Wales Clinical School UNSW. "Transplantation of fetal pig islet-like cell clusters as therapy for diabetes." 2007. http://handle.unsw.edu.au/1959.4/40870.

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Fetal pig islet-like cell clusters (ICCs) were transplanted into the thymus or omentum of STZ-induced diabetic pigs immunosuppressed with cyclosporine (CsA) and deoxyspergualin (DSG), as a potential treatment for type 1 diabetes. C-peptide levels in response to glucagon and arginine significantly increased over time using 1 litter of ICCs with highest levels obtained at 100 days post-transplantation. Increasing the number of ICCs to 2 litters was not advantageous. Histology of the graft showed all 4 pancreatic endocrine cells. Normoglycaemia was achieved for transient periods without insulin a
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Churchill, Angela Josephine. "Spatiotemporal and Mechanistic Analysis of Nkx2.2 Function in the Pancreatic Islet." Thesis, 2016. https://doi.org/10.7916/D84M94N2.

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Pancreatic beta cell specification is a complex process, requiring proper function of numerous transcription factors. Nkx2.2 is a transcription factor that is crucial for beta cell formation, and is expressed early and throughout pancreatic development. Nkx2.2-/- mice display complete loss of the beta cell lineage and defects in the specification of other endocrine cell types, demonstrating the importance of Nkx2.2 in establishing proper endocrine cell ratios. Recent studies have also demonstrated a role for Nkx2.2 within the mature beta cell to maintain identity and function. This thesi
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50

"Ability of [beta]-cell function tests and autoimmune markers to clarify the type of diabetes in adult patients." Malmö : Dept. of Medicine, University of Lund, Malmö General Hospital, 1994. http://books.google.com/books?id=jNlqAAAAMAAJ.

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