Journal articles: 'ISH'

1

Levine, Etan, and Savyon Liebrecht. "Ish, Ishah we-Ish." World Literature Today 73, no. 2 (1999): 386. http://dx.doi.org/10.2307/40154836.

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Christiansen, J. H. "One ISH, two ISH, red ISH, blue ISH: choosing the right in situ hybridisation protocol." Development 133, no. 24 (November 15, 2006): 4802–3. http://dx.doi.org/10.1242/dev.02632.

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Ellis, Harvey. "flu-ish." Lancet 351, no. 9108 (April 1998): 1069. http://dx.doi.org/10.1016/s0140-6736(05)79047-4.

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Field, Allyson Nadia. "Woke-ish." ASAP/Journal 3, no. 2 (2018): 217–21. http://dx.doi.org/10.1353/asa.2018.0013.

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5

Williams, Brittany M., and Georgianna Martin. "Grown-ish." Journal of Student Affairs Research and Practice 56, no. 3 (April 3, 2019): 358–60. http://dx.doi.org/10.1080/19496591.2018.1506797.

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6

Lee, Hokyou, Yuichiro Yano, So Mi Jemma Cho, Jong Heon Park, Sungha Park, Donald M. Lloyd-Jones, and Hyeon Chang Kim. "Cardiovascular Risk of Isolated Systolic or Diastolic Hypertension in Young Adults." Circulation 141, no. 22 (June 2, 2020): 1778–86. http://dx.doi.org/10.1161/circulationaha.119.044838.

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Background: Little is known regarding health outcomes associated with isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), or systolic and diastolic hypertension (SDH) among young adults with stage 1 hypertension, defined using the 2017 American College of Cardiology/American Heart Association blood pressure (BP) guideline. Methods: From a nationwide health screening database, we included 6 424 090 participants, aged 20 to 39 years, who were not taking antihypertensive medication at the baseline examination in 2003 to 2007. Participants were categorized as having normal BP (untreated systolic BP [SBP] <120/diastolic BP [DBP] <80 mm Hg; n=2 665 310); elevated BP (SBP 120–129/DBP <80 mm Hg; n=705 344); stage 1 IDH (SBP <130/DBP 80–89 mm Hg; n=1 271 505); stage 1 ISH (SBP 130–139/DBP <80 mm Hg; n=255 588); stage 1 SDH (SBP 130–139/DBP 80–89 mm Hg; n=711 503); and stage 2 hypertension (SBP ≥140, DBP ≥90 mm Hg; n=814 840). The primary outcome was composite cardiovascular disease (CVD) events, including myocardial infarction, stroke, heart failure, and CVD-related death. Results: The median age of the participants was 30 years and 60.9% were male. Over a median follow-up of 13.2 years, 44 070 new CVD events occurred. With normal BP as the reference, multivariable-adjusted hazard ratios (95% CIs) for CVD events were 1.14 (1.09–1.18) for elevated BP, 1.32 (1.28–1.36) for stage 1 IDH, 1.36 (1.29–1.43) for stage 1 ISH, 1.67 (1.61–1.72) for stage 1 SDH, and 2.40 (2.33–2.47) for stage 2 hypertension. Conclusions: Among young adults, stage 1 ISH, IDH, and SDH were all associated with higher CVD risks than normal BP. The CVD risks of stage 1 ISH and IDH were similar to each other but lower than the risk of stage 1 SDH. Categorizing young adults with stage 1 hypertension further into stage 1 ISH, IDH, and SDH may improve risk stratification for identifying high-risk individuals.

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Šafus, P., M. Štípková, L. Stádník, J. Přibyl, and V. Čermák. "Sub-indexes for bulls ofHolsteinbreed in theCzechRepublic." Czech Journal of Animal Science 50, No. 6 (December 10, 2011): 254–65. http://dx.doi.org/10.17221/4166-cjas.

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Sub-indexes were constructed for bulls of the Holstein breed according to groups of production traits – production index for milk (IPH), sub-indexes for reproduction (IRH), longevity (IDH), health resistance (IOH) and fitness (IFH). Every index for selection for a group of traits applies all available information – breeding values for traits of milk performance, fertility and linear type trait classification. The sub-indexes were compared with the total index (SIH). The accuracy of total selection index (SIH) was 69.30%, the accuracies of the other indexes were as follows: IPH 83.32%, IRH 56.04%, IDH 9.80%, IOH 15.57% and IFH 9.86%. All of the indexes were standardised to have the mean 100 and standard deviation 12. Simplified index ZSIH was developed as a sum of IPH, IRH and IDH; its correlation with the total index is r = 0.992. If IPH is used, the values of secondary functional traits decrease. The use of IDH, IOH and IFH results in a decrease in milk performance. Selection differences, i.e. changes in breeding values at various intensities of selection according to some indexes and breeding values for kg of milk and kg of milk proteins, were tested on the basis of breeding values in a sample of the domestic population of bulls. The production index was compared with production indexes used in other countries. Correlations between production indexes were higher than r = 0.790.  

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Bates, Jane. "Forever young-ish." Nursing Standard 18, no. 20 (January 28, 2004): 23. http://dx.doi.org/10.7748/ns.18.20.23.s29.

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Rosen, Rachel. "GOT MILK-ish?" Journal of Pediatric Gastroenterology & Nutrition 71, no. 2 (May 26, 2020): 149. http://dx.doi.org/10.1097/mpg.0000000000002800.

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10

de Arozena, Barbara Pastor. "ΜΕΡΟΠΕΣ "Glitter-Ish"." Classical Philology 88, no. 2 (April 1993): 137–38. http://dx.doi.org/10.1086/367348.

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Watts, Peter. "Liver-ish allsorts." Food and Chemical Toxicology 23, no. 3 (March 1985): 409–10. http://dx.doi.org/10.1016/0278-6915(85)90089-4.

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12

Oltra-Massuet, Isabel. "Towards a morphosyntactic analysis of -ish." Word Structure 10, no. 1 (April 2017): 54–78. http://dx.doi.org/10.3366/word.2017.0100.

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This article deals with the morphosyntactic and semantic properties of the adjectives derived with the English morpheme -ish. The main goal of the paper is to outline a morphosyntactic analysis of -ish that: (i) accounts for its cross-categorial nature, (ii) derives its surface polysemy, and (iii) is compatible with Bochnak & Csipak's (2014) recent semantic analysis of deadjectival -ish (for example, reddish) and free-standing propositional -ish (for example, I liked the movie …ish) as a metalinguistic degree operator. Focusing on the analysis of the various subtypes of bounded -ish forms, this paper develops a unified morphosyntactic approach to -ish with a single shared semantics, and suggests that the cross-categorial and polysemous nature of -ish derives from three main closely interrelated factors: (i) the source of the degree variable that -ish targets, whether syntactic, lexical, or metalinguistic; (ii) the syntactic realization site of -ish; and (iii) the late insertion of the underspecified morpheme -ish.

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Greacen, Robert, and Hugo Hamilton. "What Ish My Tongue?" Books Ireland, no. 284 (2006): 81. http://dx.doi.org/10.2307/20632892.

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Keefe, Joan Trodden. "What Ish My Language?" World Literature Today 59, no. 1 (1985): 5. http://dx.doi.org/10.2307/40140522.

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Rüschoff, Josef, Iris Nagelmeier, Bharat Jasani, and Oliver Stoss. "ISH-basierte HER2-Diagnostik." Der Pathologe 41, no. 6 (October 1, 2020): 606–13. http://dx.doi.org/10.1007/s00292-020-00841-5.

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&NA;, &NA;. "Announcement from the ISH." Journal of Hypertension 11, no. 7 (July 1993): H44. http://dx.doi.org/10.1097/00004872-199307000-00015.

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Jouret, Jill. "32nd ISH World Congress." Lancet Oncology 9, no. 12 (December 2008): 1128. http://dx.doi.org/10.1016/s1470-2045(08)70299-7.

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18

Wee, John Zhu-En. "Maacah and Ish-Tob." Journal for the Study of the Old Testament 30, no. 2 (December 2005): 191–99. http://dx.doi.org/10.1177/0309089205060614.

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19

Ball, Philip. "Is photosynthesis quantum-ish?" Physics World 31, no. 4 (April 2018): 44–48. http://dx.doi.org/10.1088/2058-7058/31/4/39.

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20

COHEN, MICHAEL R. "A Ticlid-ish situation." Nursing 32, no. 5 (May 2002): 28. http://dx.doi.org/10.1097/00152193-200205000-00026.

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21

Duarte, Rui, and António Guedes de Oliveira. "Between Shi and Ish." Discrete Mathematics 341, no. 2 (February 2018): 388–99. http://dx.doi.org/10.1016/j.disc.2017.09.006.

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22

Lin, C. "Detection of human papillomavirus in laryngeal neoplasia by ISH and PCR-ISH." Otolaryngology - Head and Neck Surgery 129, no. 2 (August 2003): P184. http://dx.doi.org/10.1016/s0194-5998(03)01073-8.

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23

Kerstens, H. M., P. J. Poddighe, and A. G. Hanselaar. "A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramine." Journal of Histochemistry & Cytochemistry 43, no. 4 (April 1995): 347–52. http://dx.doi.org/10.1177/43.4.7897179.

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For amplification of in situ hybridization (ISH) signals, we describe a method using catalyzed reporter deposition (CARD). This amplification method is based on the deposition of biotinylated tyramine (BT) at the location of the DNA probe. The BT precipitate can then visualized with fluorochrome- or enzyme-labeled avidin. Both for bright-field ISH (BRISH) and for fluorescence ISH (FISH), the detection limit was highly increased. This method is especially suitable for visualization of very weak ISH signals, such as those obtained by ISH using locus-specific DNA probes. Furthermore, CARD amplification of ISH signals (CARD-ISH) is highly sensitive, rapid, flexible, and easy to implement. Successful application of CARD-ISH with locus-specific DNA probes on histological and cytological samples may improve the determination of structural chromosomal aberrations in archival material.

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Bartlett, J. M. S., Fiona M. Campbell, Merdol Ibrahim, Anthony O’Grady, Elaine Kay, Catherine Faulkes, Nadine Collins, et al. "A UK NEQAS ISH Multicenter Ring Study Using the VentanaHER2Dual-Color ISH Assay." American Journal of Clinical Pathology 135, no. 1 (January 2011): 157–62. http://dx.doi.org/10.1309/ajcpvprkk1enedgq.

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25

Bonvicini, Francesca, Claudia Filippone, Elisabetta Manaresi, Giovanna Angela Gentilomi, Marialuisa Zerbini, Monica Musiani, and Giorgio Gallinella. "Peptide Nucleic Acid–Based In Situ Hybridization Assay for Detection of Parvovirus B19 Nucleic Acids." Clinical Chemistry 52, no. 6 (June 1, 2006): 973–78. http://dx.doi.org/10.1373/clinchem.2005.064741.

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Abstract Background: Peptide nucleic acid (PNA) molecules are known to bind complementary nucleic acid sequences with a much stronger affinity and with more stable binding than DNA or RNA molecules. We chose parvovirus B19, which is diagnosed by detection of nucleic acids by in situ hybridization assay (ISH) and/or PCR, as an experimental model to develop an ISH assay that uses biotinylated PNA probes to detect viral genome in clinical specimens. Methods: We first optimized the PNA-ISH assay on B19-infected and mock-infected UT-7/EpoS1 cells and then tested the assay on archival B19 specimens and on consecutive specimens. All data were compared with data obtained with a standardized DNA-based ISH assay and confirmed by a PCR-ELISA. Results: PNA-ISH detected B19 genome in a higher number of B19-infected UT-7/EpoS1 cells and with a more defined localization of viral nucleic acids than the standardized DNA-ISH assay. Moreover, PNA-ISH was able to detect B19 genome in all positive archival samples, whereas DNA-ISH failed in 5 samples. PNA-ISH detected more positive samples than DNA-ISH when consecutive specimens were analyzed, and a close agreement was found with PCR-ELISA results. Conclusions: The PNA-ISH assay had sensitivity and specificity comparable to a PCR assay and was more practical and quicker to perform than standard hybridization assays. The assay may be a suitable diagnostic test for the detection of viral nucleic acids in clinical specimens.

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Keung, Elaine S., Rhona J. Souers, Julia A. Bridge, William C. Faquin, Rondell P. Graham, Meera R. Hameed, James S. Lewis, Jason D. Merker, Patricia Vasalos, and Joel T. Moncur. "Comparative Performance of High-Risk Human Papillomavirus RNA and DNA In Situ Hybridization on College of American Pathologists Proficiency Tests." Archives of Pathology & Laboratory Medicine 144, no. 3 (September 4, 2019): 344–49. http://dx.doi.org/10.5858/arpa.2019-0093-cp.

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Context.— Detection of high-risk human papillomavirus (HR-HPV) in squamous cell carcinoma is important for classification and prognostication. In situ hybridization (ISH) is a commonly used HR-HPV–specific test that targets viral RNA or DNA. The College of American Pathologists (CAP) provides proficiency testing for laboratories performing HR-HPV ISH. Objective.— To compare the analytical performance of RNA- and DNA-based ISH methods on CAP HR-HPV proficiency tests. Design.— Data from the 2016–2018 CAP HPV ISH proficiency testing surveys were reviewed. These surveys consist of well-characterized samples with known status for HR-HPV, including 1 to 2 copies, 50 to 100 copies, 300 to 500 copies, and no copies of HR-HPV per cell. Results.— Ninety-five participants submitted 1268 survey results from 20 cores. Overall, RNA ISH had a significantly higher percentage of correct responses than DNA ISH: 97.4% (450 of 462) versus 80.6% (650 of 806) (P < .001). This disparity appears to be the consequence of a superior sensitivity of RNA ISH compared to DNA ISH for samples with 1 to 2 and with 50 to 100 copies of HR-HPV per cell: 95.2% (120 of 126) versus 53.8% (129 of 240), P < .001, respectively, and 100% (89 of 89) versus 76.3% (119 of 156), P < .001, respectively. Conclusions.— An assessment of CAP HR-HPV proficiency test performance indicates that RNA ISH shows significantly higher accuracy than DNA ISH owing to higher analytical sensitivity of RNA ISH in tumors with low (1–2 copies per cell) to intermediate (50–100 copies per cell) HR-HPV viral copy numbers. These data support the use of RNA over DNA ISH in clinical laboratories that perform HR-HPV testing as part of their testing algorithms.

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Brackett, Diane G., Azfar Neyaz, Kshitij Arora, Ricard Masia, Anthony Mattia, Lawerence Zukerberg, Joseph Misdraji, et al. "Cholangiolar pattern and albumin in situ hybridisation enable a diagnosis of intrahepatic cholangiocarcinoma." Journal of Clinical Pathology 73, no. 1 (August 17, 2019): 23–29. http://dx.doi.org/10.1136/jclinpath-2019-206055.

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AimsThe histological distinction of intrahepatic cholangiocarcinoma (ICC) from metastatic adenocarcinoma remains a challenge. The primary goal was to evaluate the diagnostic value of morphology and albumin expression in the diagnosis of ICC.MethodsWe evaluated morphological patterns in 120 ICCs and 677 non-hepatic adenocarcinomas and performed in situ hybridisation (ISH) stain for albumin in the former cohort (retrospective cohort). We also identified 119 samples from primary and metastatic lesions, the validation cohort, in which albumin ISH was performed as part of the diagnostic workup. Targeted sequencing was performed on selected cases. We also mined existing expression profiling data including cases from The Cancer Genome Atlas (TCGA) (41 760 unique samples).ResultsIn the retrospective cohort, 45% of ICCs and <1% of non-hepatic adenocarcinomas showed a cholangiolar pattern; albumin ISH was positive in 93% of ICCs with significant intratumorous heterogeneity. In the validation cohort, 29% of ICCs showed a cholangiolar pattern and 88% expressed albumin, while all metastatic non-hepatic neoplasms were negative (n=37) (sensitivity 88% and specificity 100%). Targetable genetic alterations (IDH mutations and FGFR2 fusions) were identified in 31% of ICCs (10 of 32). An analysis of the TCGA data validated the specificity of the albumin assay.ConclusionsThe cholangiolar pattern and albumin RNA ISH distinguishes ICC from metastatic adenocarcinoma with high specificity. Given the high prevalence of targetable mutations in ICC, albumin RNA ISH is an essential component in the workup of tumours of uncertain origin. A specific diagnosis of ICC could trigger molecular testing and uncover targetable genetic alterations.

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Fanaian, Naim K., Cynthia Cohen, Sandra Waldrop, Jennifer Wang, and Bahig M. Shehata. "Epstein-Barr Virus (EBV)-Encoded RNA: Automated In-Situ Hybridization (ISH) Compared with Manual ISH and Immunohistochemistry for Detection of EBV in Pediatric Lymphoproliferative Disorders." Pediatric and Developmental Pathology 12, no. 3 (May 2009): 195–99. http://dx.doi.org/10.2350/07-07-0316.1.

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Detection of Epstein-Barr virus (EBV) may be achieved by various methods, including EBV-encoded RNA (EBER) in-situ hybridization (ISH) and immunohistochemistry (IHC) for latent membrane protein (LMP-1). We compared novel automated ISH and IHC techniques in pediatric lymphoproliferative disorders with results obtained by manual ISH. Thirty-seven pediatric cases previously studied by manual EBER ISH (including 18 EBER-positive, 15 EBER-negative, and 4 EBER-equivocal cases) were used for the study. Automated EBER ISH and automated LMP-1 IHC were performed using the BondMax autostainer and prediluted EBER probe and EBV cell surface 1 to 4 at 1:50 dilution, respectively. Results of each of the automated techniques for EBV detection were compared with results by manual EBER ISH. Compared with manual EBER ISH as the gold standard, automated ISH had a sensitivity and specificity of 94% and 69%, respectively, accuracy of 83%, positive predictive value (PPV) of 79%, and negative predictive value (NPV) of 90%. Automated IHC had a sensitivity of 44%, specificity of 93%, accuracy of 67%, PPV of 88%, and NPV of 59%. Automated ISH and IHC correlated significantly ( P < 0.045). Automated ISH is useful for diagnosis of EBV-related pediatric neoplasms, being easy to perform and interpret and requiring only the technologist's time to set up and having a high sensitivity and NPV. The automated IHC protocol is of too low sensitivity for routine use, although results show high specificity and PPV.

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Givan, Scott A., and Kevin J. Cummings. "Intermittent severe hypoxia induces plasticity within serotonergic and catecholaminergic neurons in the neonatal rat ventrolateral medulla." Journal of Applied Physiology 120, no. 11 (June 1, 2016): 1277–87. http://dx.doi.org/10.1152/japplphysiol.00048.2016.

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5-HT neurons contribute to autoresuscitation and survival during intermittent severe hypoxia (IsH). In adults, catecholaminergic neurons in the ventrolateral medulla (VLM) contribute to the autonomic response to hypoxia. We hypothesized that 1) catecholaminergic neurons in the neonatal VLM are activated following IsH, 2) this activation is compromised following an acute loss of brain stem 5-HT, and 3) IsH induces cellular and/or transcriptomic plasticity within catecholaminergic and serotonergic neurons that are within or project to the VLM, respectively. To test these hypotheses, we treated rat pups with 6-fluorotryptophan, a tryptophan hydroxylase (TPH) inhibitor, and then exposed treated and vehicle controls to IsH or air. Along with immunohistochemistry to detect tyrosine hydroxylase (TH)- or Fos-positive neurons, we used RNA sequencing to resolve the effects of IsH and 5-HT deficiency on the expression of serotonergic and catecholaminergic system genes in the VLM. 5-HT deficiency compromised autoresuscitation and survival. IsH significantly increased the number of identifiable TH-positive VLM neurons, an effect enhanced by 5-HT deficiency ( P = 0.003). Contrary to our hypothesis, 5-HT-deficient pups had significantly more Fos-positive neurons following IsH ( P = 0.008) and more activated TH-positive neurons following IsH or air ( P = 0.04). In both groups the expression of the 5-HT transporter and TPH2 was increased following IsH. In 5-HT-deficient pups, the expression of the inhibitory 5-HT1A receptor was decreased following IsH, while the expression of DOPA decarboxylase was increased. These data show that the serotonergic and catecholaminergic systems in the VLM of the neonatal rat are dynamically upregulated by IsH, potentially adapting cardiorespiratory responses to severe hypoxia.

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Birkenbihl, Rainer P., and Walter Vielmetter. "Complete maps of IS1, IS2, IS3, IS4, IS5, IS30 and IS150 locations in Escherichia coli K12." Molecular and General Genetics MGG 220, no. 1 (December 1989): 147–53. http://dx.doi.org/10.1007/bf00260869.

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31

Hagiwara, Yuta, Naoki Takao, Tatsuro Takada, Takahiro Shimizu, Tomohide Yoshie, Takayuki Fukano, Yoshiaki Tokuyama, Noriko Usuki, Toshihiro Ueda, and Yasuhiro Hasegawa. "Contrast-enhanced carotid ultrasonography and MRI plaque imaging to identify patients developing in-stent intimal hyperplasia after carotid artery stenting." Medical Ultrasonography 21, no. 2 (May 2, 2019): 170. http://dx.doi.org/10.11152/mu-1774.

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Aim: In-stent intimal hyperplasia (ISH) observed after carotid artery stenting (CAS) may lead to in-stent restenosis. We aimed to investigate whether contrast-enhanced carotid ultrasonography (CEUS) and magnetic resonance imaging (MRI) plaque imaging prior to CAS are predictive for ISH at 6 months after CAS.Material and method: A total of 14 patients (13 men, 1 woman; mean age, 74.2 years) were prospectively enrolled. CEUS and MRI plaque imaging were performed before CAS. ISH was diagnosed by carotid angiography at 6 months after CAS. Patients were divided into two groups based on the thicknessof ISH and age, risk factors, enhancement in CEUS, MRI plaque imaging and number of replaced stents were compared between groups.Results: Carotid angiography at 6 months after CAS revealed ISH in 10 patients. Plaque enhancement on CEUS was observed in 6 patients, all of whom showed ISH. A significant association was seen between plaque enhancement on CEUS and development of ISH (χ2 test, CEUS enhancement (+) 100% vs. CEUS enhancement (-) 50% p=0.040). Carotid plaques in 12 patients were diagnosed as unstable by MRI plaque imaging. Presence of ISH was significantly associated with unstable plaque diagnosed by MRI plaque imaging (χ2 test, unstable 83% vs. stable 0%; p=0.016).Conclusion: Carotid plaque MRI and CEUS may be useful to predict ISH after CAS.

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Ivakhiv, Adrian. "Pagan(ish) Senses and Sensibilities." Pomegranate: The International Journal of Pagan Studies 17, no. 1-2 (January 18, 2016): 194–205. http://dx.doi.org/10.1558/pome.v17i1-2.29680.

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Spisak, April. "Love, Ish by Karen Rivers." Bulletin of the Center for Children's Books 70, no. 8 (2017): 378. http://dx.doi.org/10.1353/bcc.2017.0314.

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Chalmers, John, Lawrie Beilin, Giuseppe Mancia, Judith Whitworth, and Alberto Zanchetti. "International Society of Hypertension (ISH)." Journal of Hypertension 21, no. 4 (April 2003): 649–50. http://dx.doi.org/10.1097/00004872-200304000-00001.

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Veerabhadrappa, Praveen, Dylan Burger, Bo Carlberg, Fadi Charchar, Maciej Tomaszewski, and Stephen Harrap. "ISH Hypertension Future Leaders Group." Journal of Hypertension 29, no. 8 (August 2011): 1664–65. http://dx.doi.org/10.1097/hjh.0b013e3283491598.

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Cornwell, Gareth. "For a new-ish criticism." Scrutiny2 17, no. 1 (May 2012): 5–11. http://dx.doi.org/10.1080/18125441.2012.706026.

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Sullivan, Jas M., and Gheni N. Platenburg. "From Black-ish to Blackness." Journal of Black Studies 48, no. 3 (January 29, 2017): 215–34. http://dx.doi.org/10.1177/0021934716685845.

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Prior research shows consumption of Black information affects the way people think. More specifically, it influences general racial group attitudes. However, the expectations about the amount of Black information and deeper understanding of its effect on racial identity development remain unclear. Using a unique survey data set, with large oversamples of Blacks, this article explores whether the amount of Black information consumed influences Black identity development. The findings show Black information sources positively affect racial identity development—creating a sense that race is a more important aspect of the individuals’ definitions of self (i.e., racial centrality). The flip side, however, is greater consumption of Black information decreases public regard, prompting Blacks to believe other groups have a more negative feeling toward them. Thus, Black media plays a dual function in racial identity development—both positive and negative.

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Pierce, M. "THE FURTHER DEGRAMMATICALIZATION OF -ISH." American Speech 89, no. 1 (March 1, 2014): 115–18. http://dx.doi.org/10.1215/00031283-2726431.

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Abe, Takuro, Daisuke Suyama, and Shuhei Tsujie. "The freeness of Ish arrangements." Journal of Combinatorial Theory, Series A 146 (February 2017): 169–83. http://dx.doi.org/10.1016/j.jcta.2016.09.008.

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Yoshii, A., T. Koji, N. Ohsawa, and P. K. Nakane. "In situ localization of ribosomal RNAs is a reliable reference for hybridizable RNA in tissue sections." Journal of Histochemistry & Cytochemistry 43, no. 3 (March 1995): 321–27. http://dx.doi.org/10.1177/43.3.7532657.

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Assessments of RNA integrity and its hybridizability are essential for successful implementation of in situ hybridization (ISH) for mRNA or viral RNA, particularly when paraffin-embedded specimens from surgical, biopsy, and autopsy cases are used. In this study, we examined the suitability of ISH of 28S ribosomal RNA (rRNA) for this purpose. Oligo-DNA with nucleotide sequences complementary to a well-conserved segment of 28S rRNA with auxiliary adenine-thymine-thymine (ATT) repeats at the 3' and 5' ends was synthesized. The oligo-DNA was made antigenic by converting the adjacent thymines to T-T dimers by UV irradiation and was used as a probe for ISH of 28S rRNA. The T-T dimers were detected by enzyme immunohistochemistry. When the results of ISH rRNA staining and that of total RNA staining by methyl green/pyronin Y were compared for various types of sections prepared from rat and human tissues, the staining intensities of total RNA did not always match those of ISH rRNA staining. In paraffin sections of formalin-fixed tissues, the degree of proteinase digestion influenced the ISH rRNA staining intensity, whereas it had no effect on the total RNA staining intensity. The intensities of ISH rRNA staining agreed well with those of various types of mRNA staining by ISH in 10 cases of paraffin-embedded pathological specimens. We therefore believe that ISH rRNA staining is a convenient parameter for evaluation of levels of hybridizable RNAs in tissue sections.

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Mohammad, Yousef M., Adnan Qureshi, M. Fareed K. Suri, Zulfiqar Ali, Lee R. Guterman, and Nelson L. Hopkins. "Isolated Systolic Hypertension and the Long-Term Risk of Stroke: A 20-Year follow-up of the National Health and Nutrition Survey." Stroke 32, suppl_1 (January 2001): 363. http://dx.doi.org/10.1161/str.32.suppl_1.363-a.

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P133 Background and Purpose: Isolated systolic hypertension (ISH) is frequently observed in elderly persons. The effect of ISH on the long-term risk for stroke and stroke subtypes is unclear. We performed this study to evaluate the long-term risk of stroke in persons with ISH. METHODS: We evaluated the incidence of stroke and stroke subtypes(ischemic and hemorrhagic) in a nationally representative cohort of 14,047 adults who participated in the First National Health and Nutrition Examination Survey during the 20-year follow-up. ISH was defined as a systolic blood pressure(BP)>160mmHg and diastolic BP<90mmHg. RESULTS: A total of 376 persons with ISH, 8985 persons with normotension, and 4686 persons with classic hypertension were followed. During the follow-up period, the annual incidences of ischemic stroke and intracerebral hemorrhage for patients with ISH were 1.7% and .05% respectively. After adjusting for differences in age, race,and gender, the risk for ischemic stroke was increased in persons with ISH compared to persons with normotension (odds ratio [OR]=1.6, 95% confidence interval [CI]=1.1 to 2.2). The increased risk was similar to persons with classic hypertension (OR=1.3, 95% CI=1.03 to 1.6). The risk of intracerebral hemorrhage was increased in persons with classic hypertension (OR=3.0, 95% CI=1.5 to 7.1) but not in persons with ISH (OR=0.7, 95% CI=0.1 to 2.3). CONCLUSION: Persons with ISH are at increased risk for ischemic stroke, similar to those with classic hypertension.

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Kenny, Daryn, Lu-Ping Shen, and Janice A. Kolberg. "Detection of Viral Infection and Gene Expression in Clinical Tissue Specimens Using Branched DNA (bDNA) In Situ Hybridization." Journal of Histochemistry & Cytochemistry 50, no. 9 (September 2002): 1219–27. http://dx.doi.org/10.1177/002215540205000909.

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In situ hybridization (ISH) methods for detection of nucleic acid sequences have proved especially powerful for revealing genetic markers and gene expression in a morphological context. Although target and signal amplification technologies have enabled researchers to detect relatively low-abundance molecules in cell extracts, the sensitive detection of nucleic acid sequences in tissue specimens has proved more challenging. We recently reported the development of a branched DNA (bDNA) ISH method for detection of DNA and mRNA in whole cells. Based on bDNA signal amplification technology, bDNA ISH is highly sensitive and can detect one or two copies of DNA per cell. In this study we evaluated bDNA ISH for detection of nucleic acid sequences in tissue specimens. Using normal and human papillomavirus (HPV)-infected cervical biopsy specimens, we explored the cell type-specific distribution of HPV DNA and mRNA by bDNA ISH. We found that bDNA ISH allowed rapid, sensitive detection of nucleic acids with high specificity while preserving tissue morphology. As an adjunct to conventional histopathology, bDNA ISH may improve diagnostic accuracy and prognosis for viral and neoplastic diseases.

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Wolff, Antonio C., M. Elizabeth Hale Hammond, Kimberly H. Allison, Brittany E. Harvey, Pamela B. Mangu, John M. S. Bartlett, Michael Bilous, et al. "Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update." Archives of Pathology & Laboratory Medicine 142, no. 11 (May 30, 2018): 1364–82. http://dx.doi.org/10.5858/arpa.2018-0902-sa.

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Purpose.— To update key recommendations of the American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) human epidermal growth factor receptor 2 (HER2) testing in breast cancer guideline. Methods.— Based on the signals approach, an Expert Panel reviewed published literature and research survey results on the observed frequency of less common in situ hybridization (ISH) patterns to update the recommendations. Recommendations.— Two recommendations addressed via correspondence in 2015 are included. First, immunohistochemistry (IHC) 2+ is defined as invasive breast cancer with weak to moderate complete membrane staining observed in >10% of tumor cells. Second, if the initial HER2 test result in a core needle biopsy specimen of a primary breast cancer is negative, a new HER2 test may (not “must”) be ordered on the excision specimen based on specific clinical criteria. The HER2 testing algorithm for breast cancer is updated to address the recommended workup for less common clinical scenarios (approximately 5% of cases) observed when using a dual-probe ISH assay. These scenarios are described as ISH group 2 (HER2/chromosome enumeration probe 17 [CEP17] ratio ≥2.0; average HER2 copy number <4.0 signals per cell), ISH group 3 (HER2/CEP17 ratio <2.0; average HER2 copy number ≥6.0 signals per cell), and ISH group 4 (HER2/CEP17 ratio <2.0; average HER2 copy number ≥4.0 and <6.0 signals per cell). The diagnostic approach includes more rigorous interpretation criteria for ISH and requires concomitant IHC review for dual-probe ISH groups 2 to 4 to arrive at the most accurate HER2 status designation (positive or negative) based on combined interpretation of the ISH and IHC assays. The Expert Panel recommends that laboratories using single-probe ISH assays include concomitant IHC review as part of the interpretation of all single-probe ISH assay results.

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Wolff, Antonio C., M. Elizabeth Hale Hammond, Kimberly H. Allison, Brittany E. Harvey, Pamela B. Mangu, John M. S. Bartlett, Michael Bilous, et al. "Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update." Journal of Clinical Oncology 36, no. 20 (July 10, 2018): 2105–22. http://dx.doi.org/10.1200/jco.2018.77.8738.

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Purpose To update key recommendations of the American Society of Clinical Oncology/College of American Pathologists human epidermal growth factor receptor 2 (HER2) testing in breast cancer guideline. Methods Based on the signals approach, an Expert Panel reviewed published literature and research survey results on the observed frequency of less common in situ hybridization (ISH) patterns to update the recommendations. Recommendations Two recommendations addressed via correspondence in 2015 are included. First, immunohistochemistry (IHC) 2+ is defined as invasive breast cancer with weak to moderate complete membrane staining observed in > 10% of tumor cells. Second, if the initial HER2 test result in a core needle biopsy specimen of a primary breast cancer is negative, a new HER2 test may (not “must”) be ordered on the excision specimen based on specific clinical criteria. The HER2 testing algorithm for breast cancer is updated to address the recommended work-up for less common clinical scenarios (approximately 5% of cases) observed when using a dual-probe ISH assay. These scenarios are described as ISH group 2 ( HER2/chromosome enumeration probe 17 [CEP17] ratio ≥ 2.0; average HER2 copy number < 4.0 signals per cell), ISH group 3 ( HER2/CEP17 ratio < 2.0; average HER2 copy number ≥ 6.0 signals per cell), and ISH group 4 ( HER2/CEP17 ratio < 2.0; average HER2 copy number ≥ 4.0 and < 6.0 signals per cell). The diagnostic approach includes more rigorous interpretation criteria for ISH and requires concomitant IHC review for dual-probe ISH groups 2 to 4 to arrive at the most accurate HER2 status designation (positive or negative) based on combined interpretation of the ISH and IHC assays. The Expert Panel recommends that laboratories using single-probe ISH assays include concomitant IHC review as part of the interpretation of all single-probe ISH assay results. Find additional information at www.asco.org/breast-cancer-guidelines .

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DasSarma, Shiladitya. "Mechanisms of genetic variability in Halobacterium halobium: the purple membrane and gas vesicle mutations." Canadian Journal of Microbiology 35, no. 1 (January 1, 1989): 65–72. http://dx.doi.org/10.1139/m89-010.

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Several phenotypic variants of Halobacterium halobium arise spontaneously at extremely high frequencies (up to 1%) and are readily identified by inspection of bacterial colonies. Two mutant types, those lacking the buoyant gas vesicles or the photosynthetic purple membrane, have been studied in detail by phenotypic and molecular genetic analysis. In the wild-type NRC-1 strain, the bop gene, encoding the purple membrane protein bacterio-opsin, is found on the bacterial chromosome, while the gas vesicle protein genes, gvpA and gvpC, are present on pNRC100, a multicopy plasmid of ~150 kilobase pairs. The gvpA and gvpC genes are on a single transcription unit, while the major bop mRNA is monocistronic. Essentially all of the purple membrane deficient mutants contain insertion sequence (IS) elements into or upstream of the bop gene. Two elements, ISH 1 and ISH 2, account for most (80–90%) of the purple membrane mutations, but at least three other elements, ISH 23, ISH 26, and ISH S1, have also been implicated. The gas vesicle mutants are more heterogeneous, with many displaying partial phenotypes. Three major classes of gas vesicle mutants are distinguishable: class I and class III mutants are the result of large deletions in pNCR100; however, while class I mutants are partially gas vesicle deficient and contain a correspondingly reduced number of gvpAC operon copies, class III mutants contain no detectable copies of the gas vesicle genes and are essentially completely gas vesicle deficient. Class II mutants, like the purple membrane mutants, contain IS elements into or upstream of the gas vesicle genes. At least five different IS elements are involved: ISH 2, ISH 3, ISH 4, ISH 6, and ISH 8.Key words: insertion sequence, transposable element, plasmid, Halobacterium halobium, bacteriorhodopsin, gas vesicle.

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Piovesan, EJ, E. Zukerman, PA Kowacs, and LC Werneck. "Cox-2 Inhibitor for the Treatment of Idiopathic Stabbing Headache Secondary To Cerebrovascular Diseases." Cephalalgia 22, no. 3 (April 2002): 197–200. http://dx.doi.org/10.1046/j.1468-2982.2002.00346.x.

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The idiopathic stabbing headache (ISH) is characterized by a stabbing pain of short duration, variable localization and an errant evolution pattern. As its biological mechanisms are unknown and the treatment options are little effective, this disorder shows a strong impact on the patient's life. Two females and one male, aged 76, 66 and 72 years, respectively, started presenting ISH within 20 days after the onset of a stroke. All the patients were treated for the ISH with celecoxib, a COX-2 specific inhibitor, with full recovery from ISH up to 6 days after it was first administered. The interruption of the drug 60 days after the treatment with celecoxib induced again the appearance of algic symptoms in two patients. We concluded that cerebrovascular diseases (CD) can lead to ISH and that the COX-2 inhibitor can be an effective prophylactic drug for ISH after CD.

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Jiang, Jiming, and Bikram S. Gill. "Sequential chromosome banding and in situ hybridization analysis." Genome 36, no. 4 (August 1, 1993): 792–95. http://dx.doi.org/10.1139/g93-104.

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Different combinations of chromosome N- or C-banding with in situ hybridization (ISH) or genomic in situ hybridization (GISH) were sequentially performed on metaphase chromosomes of wheat. A modified N-banding–ISH/GISH sequential procedure gave best results. Similarly, a modified C-banding – ISH/GISH procedure also gave satisfactory results. The variation of the hot acid treatment in the standard chromosome N- or C-banding procedures was the major factor affecting the resolution of the subsequent ISH and GISH. By the sequential chromosome banding – ISH/GISH analysis, multicopy DNA sequences and the breakpoints of wheat–alien translocations were directly allocated to specific chromosomes of wheat. The sequential chromosome banding– ISH/GISH technique should be widely applicable in genome mapping, especially in cytogenetic and molecular mapping of heterochromatic and euchromatic regions of plant and animal chromosomes.Key words: N-banding, C-banding, in situ hybridization, genomic in situ hybridization.

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Eeftinck Schattenkerk, Daan W., Jacqueline van Gorp, Liffert Vogt, Ron JG Peters, and Bert-Jan H. van den Born. "Isolated systolic hypertension of the young and its association with central blood pressure in a large multi-ethnic population. The HELIUS study." European Journal of Preventive Cardiology 25, no. 13 (May 29, 2018): 1351–59. http://dx.doi.org/10.1177/2047487318777430.

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Background Isolated systolic hypertension (ISH) of the young has been associated with both normal and increased cardiovascular risk, which has been attributed to differences in central systolic blood pressure and arterial stiffness. Methods We assessed the prevalence of ISH of the young and compared differences in central systolic blood pressure and arterial stiffness between ISH and other hypertensive phenotypes in a multi-ethnic population of 3744 subjects (44% men), aged <40 years, participating in the HELIUS study. Results The overall prevalence of ISH was 2.7% (5.2% in men and 1.0% in women) with the highest prevalence in individuals of African descent. Subjects with ISH had lower central systolic blood pressure and pulse wave velocity compared with those with isolated diastolic or systolic-diastolic hypertension, resembling central systolic blood pressure and pulse wave velocity values observed in subjects with high-normal blood pressure. In addition, they had a lower augmentation index and larger stroke volume compared with all other hypertensive phenotypes. In subjects with ISH, increased systolic blood pressure amplification was associated with male gender, Dutch origin, lower age, taller stature, lower augmentation index and larger stroke volume. Conclusion ISH of the young is a heterogeneous condition with average central systolic blood pressure values comparable to individuals with high-normal blood pressure. On an individual level ISH was associated with both normal and raised central systolic blood pressure. In subjects with ISH of the young, measurement of central systolic blood pressure may aid in discriminating high from low cardiovascular risk.

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Ghabril, M., R. C. Dickson, M. Krishna, R. Lloyd, J. Aranda-Michel, A. Keaveny, R. Satyanarayana, and H. Bonatti. "Persistence of Hepatitis C RNA in Liver Allografts Is Associated with Histologic Progression Independent of Serologic Viral Clearance." Journal of Transplantation 2009 (2009): 1–6. http://dx.doi.org/10.1155/2009/297528.

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Background. Hepatitis C virus (HCV) nondetectability in the liver may predict a sustained viral response (SVR) in patients with an end of treatment response. HCV RNA can be detected in liver tissue by in situ hybridization (ISH).Aim. To determine if HCV nondetectability in liver allografts by ISH can predict SVR in patients who cleared virus serologically on treatment.Methods. Twenty five patients with undetectable serum HCV on Interferon/Ribavirin therapy for HCV recurrence post liver transplant (LT) were studied. All had biopsies at 4 months post LT (baseline) and follow up with HCV ISH analysis performed.Results. 10 were ISH positive (group 1); 15 were ISH negative (group 2). Groups 1 and 2 had similar patient, donor, and viral characteristics at LT, as well as treatment duration at the time of the ISH assayed liver biopsy (13±16versus10±4monthsP= .24). However, group 1 had longer total treatment duration (24±10versus14±5months,P= .001). Eight (80%) group 1 and 9 (60%) group 2 patients achieved SVR. Mean grade and stage (modified Ishak score) were similar at 4 months, however, group 1 had higher grade (3±1.7versus1.6±1.3,P= .039) and stage (1.4±1.4versus0.5±0.6,P= .084) on the ISH assayed biopsy, after similar post LT intervals (23±10versus24±12months,P= .91).Conclusion. Allograft HCV ISH nondetectability does not predict SVR in treatment responsive HCV recurrence, but is associated with less severe histologic disease.

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Senthil Kumar, S., P. Govindaraj, and C. Appunu. "Morphological and Molecular Characterization of High Biomass IGH, ISH and Saccharum Hybrids." Sugar Tech 17, no. 3 (June 3, 2014): 243–51. http://dx.doi.org/10.1007/s12355-014-0327-0.

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Journal articles on the topic 'ISH'

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