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Harris, Tabea [Verfasser], and Carola [Akademischer Betreuer] Trips. "-ish / Ish: Aspects of a suffix turned free morpheme / Tabea Harris ; Betreuer: Carola Trips." Mannheim : Universitätsbibliothek Mannheim, 2021. http://d-nb.info/1237618355/34.
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Puniyani, Kriti. "Spatiotemporal Gene Networks from ISH Images." Research Showcase @ CMU, 2013. http://repository.cmu.edu/dissertations/338.
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As large-scale techniques for studying and measuring gene expressions have been developed, automatically inferring gene interaction networks from expression data has emerged as a popular technique to advance our understanding of cellular systems. Accurate prediction of gene interactions, especially in multicellular organisms such as Drosophila or humans, requires temporal and spatial analysis of gene expressions, which is not easily obtainable from microarray data. New image based techniques using in-sit hybridization(ISH) have recently been developed to allowlarge-scale spatial-temporal profiling of whole body mRNA expression. However, analysis of such data for discovering new gene interactions still remains an open challenge. This thesis studies the question of predicting gene interaction networks from ISH data in three parts. First, we present SPEX2, a computer vision pipeline to extract informative features from ISH data. Next, we present an algorithm, GINI, for learning spatial gene interaction networks from embryonic ISH images at a single time step. GINI combines multi-instance kernels with recent work in learning sparse undirected graphical models to predict interactions between genes. Finally, we propose NP-MuScL (nonparanormal multi source learning) to estimate a gene interaction network that is consistent with multiple sources of data, having the same underlying relationships between the nodes. NP-MuScL casts the network estimation problem as estimating the structure of a sparse undirected graphical model. We use the semiparametric Gaussian copula to model the distribution of the different data sources, with the different copulas sharing the same covariance matrix, and show how to estimate such a model in the high dimensional scenario. We apply our algorithms on more than 100,000 Drosophila embryonic ISH images from the Berkeley Drosophila Genome Project. Each of the 6 time steps in Drosophila embryonic development is treated as a separate data source. With spatial gene interactions predicted via GINI, and temporal predictions combined via NP-MuScL, we are finally able to predict spatiotemporal gene networks from these images.
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Lai, Dominic. "Compliant(ish) : norm evasion and avoidance in doping, tax, and Indigenous rights." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59082.
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Norms literature assume that opponents of norms do not comply with its prescriptions, and will actively reject its’ logic patterns. While this may describe some patterns of norm contestation, actors that openly contest generally accepted norms may incur unbearable penalties. Other theories presume that a state may accept a norm’s logic patterns, but not comply as a result of an inability to comply. Evasion and avoidance present a different way of envisioning how actors may approach norms, compliance, and logic systems by delinking compliance and acceptance of normative logic. These concepts introduce opportunism as a key variable that also challenges presumptions about actor intentions. By examining the cases of doping in sport, tax law, and Indigenous rights, a pattern emerges where actors have been able to manipulate a norm’s compliance signals to technically comply with a norm while defeating the norm’s objectives. In turn, this allows actors to enjoy the benefits of non-compliance or partial compliance and compliance simultaneously, and escape detection by appearing to be compliant with the norm itself. These two concepts implicitly challenge the concept that compliance is a binary variable, and builds on a growing literature that suggests that the grey area between the poles of compliance and non-compliance may be more complex than expected.Arts, Faculty of
Political Science, Department of
Graduate
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Amos, Pauline. "Self(ish)-fusion thinking and practice : a (mainly) visual investigation of poly-modal art-making." Thesis, University of Plymouth, 2004. http://hdl.handle.net/10026.1/2637.
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If it could be seen that a 'body of training' has a crucial impact on a creative practice, my own history of 'training' would be difficult to trace within any specific discipline or mode of self-expression. I have been 'trained' as a visual artist, actor, performance-artist, and to some extent, musician/sonic performer. This coexistence of modalities with associated meta-praxis, has in fact created a set of parallel dimensions embodied within a collective of theories as well as practices. On the one hand, this collective of practices has involved a view of myself (and what I make) as a form of 'research object'. But on another hand, the very intersection between these modes of practice has inevitably involved a form of experimentation and enquiry that has stretched far beyond the boundaries of 'self '. Not only have these diverse practices 'informed' each other, but the fusion of these modalities has created a set of research questions that interrogate the validity of self (and self-practice) as a form of research outcome. Consequently, at a key stage of my research, I decided to 'pull focus' on particular disciplinary modes and practices in order to best define my practice and its context within notions of defining a 'self. This is why the bulk of my practical submission has taken the form of a selected series of mainly large-scale works on paper. At an earlier stage, my visual work was equally disposed of representational (figurative) and non-representational outcomes. However, notions (and questions) of 'self are capable of presentation in the abstract domain of signs, symbols and 'signals', I chose to represent questions about intuition, emotion, spontaneity and improvisation via the submission of a series of entirely abstract work. In many if not all cases, the process of execution is as important as the outcome. To this end, where appropriate, I have also chosen to represent 'process' by means of:- • Reproductions (where appropriate) of sketches and preparatory notations in the form of image, text, video and other forms of documentation, from time to time; • Installed performance experiments of either a personal or collaborative nature (the latter normally being in the form of collaborations between myself and other visual artists or musicians) and represented by means of edited parts from video documentation; • Sonic experiments and collaborations between myself in the role of musician, and other musicians (CD submission). However, and most importantly, the arrangement and ordering of the completed works on paper is also intended to represent a documentation of a process where notions of 'completion', via a series, can be seen as evidence of the nature of a continuous and gradually unfolding process of experimentation and 'testing'. In other words, the entire body of completed works on paper should be seen as an holistic exercise in questioning the position of my own body (and practice) as illuminating the position of my mind and senses within an evolving set of works. The written thesis follows this same 'chain' format. It is constructed in the form of a textual continuum that both spans and links several theoretical and practical discourses. In each case (with the exception of the introduction and conclusion), I have sought to analyse, evaluate, document and criticise the sources, processes and outcomes of each work. I have also taken the view that the series of works beg questions of generic relationships. There is an obvious diversity of 'idea' but in the main, the paintings/drawings are represented by a relatively heterogeneous set of stylistic practices. These heterogeneous elements emerged as a result of a highly personalised journey of exploration. At no point have I taken the view that theoretical contexts (those derived more usually from an historical analysis of past and current trends), will be the determining core of either my practice or my research with and into that practice. The written thesis charts a progression of a body of work that has been practice-led. In so-doing, it also connects several modes of creative self-expression together; most notably, music, theatre and visual-performance. Consequently, and because I believe the process of working to be as significant (if not more so) as the outcomes. The written thesis is both a 'history' and a critique of that journey. All my practice is 'primed' by different approaches to research. The written thesis embodies the three stages that articulate the sequencing of my practice, namely; • Source-research-memory-theory-experience; • Practice-improvisation- visual experimentation; • Review and notions of progression/linkage between one state (and stage) of practice and another. The introduction is concerned with the contextualisation of my practice and descriptions of the 'ordering' and determinants for making work. The conclusion concerns itself with the analysis and debriefing that accrues from a body of completed work. But I have also concluded by drawing attention to a poly-modal approach to practice, one that encompasses a 'collective' of techniques and artistic languages, across and between one mode of self-expression and another.
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Madubela, Ndumiso S. "Eish - when to use -ish-: a study in the verbalization of English lexical items in spoken Xhosa." Master's thesis, Faculty of Humanities, 2021. http://hdl.handle.net/11427/33160.
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This study examines how Xhosa speakers incorporate verbs of English origin into their lexicons with a specific focus on the -ish- suffix. The study deals with historical treatments of this phenomenon and debates its relevance and applicability to current scholarship on lexical borrowing. To ensure a wide range of data sources I used a corpus derived from interviews with 30 Xhosa speakers in Cape Town, as well as from three media sources: the first is a 1-hour long talk radio programme transcribed from the national Xhosa broadcaster, UMhlobo weNene, the second an interview with a Xhosa-speaking patient on the television programme, Siyayinqoba Beat It. The third is from social media, (Facebook, Twitter and WhatsApp). The demographics of participants in this study are predominantly urban dwellers. The youngest participant (from the surveys) was 16 years old and the oldest participant was 45 years old. I say “predominantly” as it was not possible to obtain specific background data to the two Xhosa speakers on radio and television. Very little work has been done on the way in which African languages speakers grammaticalize verbs of English origin – why, for example, do some adopted words like suffix -a (e.g. Ndiyamotivate-a – ‘I am motivating') while others suffix -ish-a (e.g. Ndiyastudy-ish-a – ‘I am studying'). The main finding of the study is that speakers incorporated verbs of English origin by suffixing -a and -ish- in their speech, they were not consciously code mixing: rather, they used these suffixes as just another resource available to them to make their communication more strategic. This could indicate that in certain urban settings the -ish- verbalizing suffix might become even more popular as people need to negotiate lifestyles that require new lexicons. It is hoped that this research will shed more light on this growing phenomenon and provide a framework for discussion of verbalizers within the greater canon of language change scholarship in South Africa as a whole. A primary function of this study was to formulate rules for the adoption of -ish- and -a and to provide statistical data as to which one is preferred by speakers.
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Cioffi, Daryl. "College President Perceptions of Personal Wellness| Exploring "Well-ish" and the Work-Life Balance of Mid-Career Private College Presidents." Thesis, Johnson & Wales University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10746629.
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Leadership has entered an age of chronic unrest. Scholars have emphasized the impact of healthy and effective leaders on organizations (Crother-Laurin, 2006), yet recent studies reveal high stress and burnout in the contemporary workplace (Walsh, 2005, 2013). The academy faces their own organizational challenges, (Archibald & Feldman, 2010) calling into question the health and effectiveness of leaders, especially at the presidential level (Duderstadt, 2010). While the study of college president wellness has been explored through multiple lenses (McNair, Duree, & Ebbers, 2011; Tekniepe, 2014; Walker & McPhail, 2009), some researchers highlight the unique needs of mid-career presidents of private institutions. To date, minimal research has been conducted on wellness for this population. Using the presidential office as the pivotal point of inquiry, this qualitative interpretive constructivist study sought to answer the following research questions: RQ1: How do mid-career college presidents perceive personal wellness? • RQ1a: What value does wellness play in the lives of mid-career presidents? • RQ1b: How do mid-career college presidents apply wellness techniques in their lives? • RQ1c: Have these wellness practices changed throughout their time as president?
Interviews with (N = 10) mid-career private college presidents were conducted, as well as an (N = 1) elite interview with an executive coach. These data were analyzed using Giorgi’s (2009) analytical strategy. Interview observation data and document analyses of various institutional documents (websites and presidential social media) supplemented the data set. Boyatzis’ (1998) data analysis strategy was applied to observation and document data. Hettler’s (1976) six dimensions of wellness were used to guide study design, develop instrumentation, and contextualize the definition of wellness used in this study. Five themes emerged from this study: mid-career college presidents identified the continuous challenges of their position, transitional issues and the need to mitigate stressors, their conscious acknowledgement of wellness, their need for social connections and family, and their efforts to pursue personal wellness in a taxing environment. These findings highlight the complexities of the mid-career college president’s quest for personal wellness. This study may assist academic leaders and board members with the knowledge to develop programs and resources for presidents, supporting wellness for future leaders.
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Jahar, Asep Saepudin. "Ab¢u Ish¢aq al-Sh¢atib¢i's reformulation of the concept of Bid'a, a study of his al-I'tis¢am." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0015/MQ54994.pdf.
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Smith, Robin Yvonne. "Hishuk ish ts'awalk - All things are one, traditional ecological knowledge and forest practices in ahousaht first nations's traditional territory, Clayoquot Sound, British Columbia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0007/MQ30233.pdf.
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com, dbearham@hotmail, and Douglas Bearham. "Identification and characterisation of two haplosporidian parasites of oysters in north Western Australia." Murdoch University, 2008. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20081114.120135.
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A cryptic haplosporidian parasite was detected infecting rock oysters from the Montebello Islands in north-western Australia using a PCR targeting the parasites small ribosomal subunit gene. The PCR products were cloned and sequenced along with the remaining sections of the parasites SSU rRNA gene. Phylogenetic analysis of the sequence generated indicated a Minchinia species (Haplosporidia). The SSU sequence generated was used to develop two in situ hybridisation assays to visualise the parasite in H/E sections as well as a PCR assay to detect the parasite. The molecular assays were assessed for specificity and sensitivity and were then used to compare the parasite to previous haplosporidian parasite infections of pearl oysters. Both assays produced positive results from the infected pearl oysters but not from other closely related haplosporidian species. An SEM and TEM electron microscopy analysis was performed on spores from both parasite species. The spores of the pearl oyster parasite had two spore wall filaments wound around the spore originating for a posterior thickening while the spores of the rock oyster parasite were covered in microtubule-like structures. These data suggests pearl oysters where co-infected with both the Haplosporidium sp. and the Minchinia sp. detected in rock oysters. No evidence of a posterior thickening could be found on the spores of the rock oyster parasite. Attempts to detect the parasite at the previous geographic sites of its detection in pearl oysters resulted in detection of the Minchinia species in tropical oysters in the Kimberley region of Western Australia by in-situ hybridisation.
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Dumont, Yves. "Supraconductivite et aspects structuraux dans les cuprates mixtes (bi)is2(sr,la)is2(cu)is1(o)is6+delta." Paris 11, 1996. http://www.theses.fr/1996PA112539.
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Sur des monocristaux, de croissance par flux, de bi-2201 substitues au lanthane, sur lesquels une correspondance entre la composition nominale en lanthane yla, et les parametres de la structure moyenne et de la structure displacive incommensurable avaient ete etablie, nous avons cherche une relation entre la temperature de transition supraconductrice, tc et yla. Par micro-analyse par sonde electronique (epma), nous montrons que le lanthane se substitue de facon homogene et continue sur le site du strontium. La composition stoechiometrique des cristaux etudies est biis2. 1sris1. 9ylaisycuis1ois6+delta. Tc n'est pas directement determine par yla. L'oxygene dans toute sa complexite est suspecte. Via le developpement d'une technique de mesure de resistivite in-situ a haute temperature, nous montrons que dans la gamme 470c, 680c, le terme residuel de la resistivite rho(t) en fonction de la temperature est modifie selon la loi de matthiessen. Tc decroit avec l'augmentation de la temperature de recuit. Le probleme de la diffusion d'oxygene et du degre d'ordre/desordre local est pose. Nous developpons une technique de mesure du coefficient seebeck s(t) en fonction de la temperature, car s(300k) a ete revele comme une mesure efficace et universelle du niveau de dopage en trous dans les autres cuprates. Nous montrons que le substitution en lanthane et les traitements thermiques sont equivalents pour la dependance en temperature de s(t), analysee en termes d'entrainement et de bande etroite. Nous tracons un diagramme de phase tc vs. S(300k) pour le systeme bi-2201 avec differents yla et differentes temperatures tr de recuit. Nous pouvons aller du regime surdope (quand yla=0) au regime sousdope (quand yla et tr sont augmentes). La difference avec les autres cuprates est l'existence d'une bifurcation dans le diagramme de phase pour yla=0. 3 qui coincide avec la transition de phase structurale passant de la symetrie monoclinique a celle orthorhombique. Une forte pression hydrostatique modifie a la fois tc et la dynamique de vortex evaluee par le champ critique resistif. Ce cuprate a bas tc, a sa supraconductivite dominee par sa structure complexe.
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Andersson, Sandra. "Validation of antibodies for tissue based immunoassays." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251344.
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In situ protein detection in human tissues using antibodies reveals the cellular protein localization, and affinity-based proteomic studies can help to discover proteins involved in the development of diseases. However, antibodies often suffer from cross-reactivity, and the lack of positive and negative tissue controls for uncharacterized proteins complicates the mapping of the proteome. The aim of this thesis is thus to improve the methodology for validating antibodies used for immunostaining on formalin-fixed paraffin-embedded tissues. Two of the papers include comparisons between mRNA-expression and immunostaining of corresponding protein. In paper I, ISH and IHC staining patterns were compared on consecutive TMA-slides. The study of well-characterized genes showed that ISH could be used for validation of antibodies. ISH was further used for antibody evaluation, and could validate four out of nine antibodies showing potentially interesting staining patterns. In paper III, transcriptomic data generated by RNA-sequencing were used to identify tissue specific expression in lymphohematopoietic tissues. An increased expression in one or more of these tissues compared to other tissue types was seen for 693 genes, and these were further compared to the staining patterns of corresponding proteins in tissues. Antibody labeling is necessary for many immunoassays. In paper II, two techniques for antibody-biotinylation were compared, aiming to find a stringent labeling method for antibodies used for immunostaining on TMAs. The ZBPA-method, binding specifically to Fc-part of antibodies, was found to be superior to the Lightning Link-biotinylation kit targeting amine groups, since labeling of amine groups on stabilizing proteins in the antibody buffer causes unspecific staining. The localization of the estrogen receptor beta (ERβ) in human normal and cancer tissues was studied in paper IV. Thorough evaluation of 13 antibodies using positive and negative control cell lines showed that only one antibody, PPZ0506, is specific for ERβ in all three immunoassays used. Contradictory to previously published data, tissue profiling using PPZ0506 showed that ERβ is expressed in a limited number of normal and cancer tissues. In conclusion, the present investigations present tools for validation of antibodies used for large-scale studies of protein expression in tissues.
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Dapaah, Gloria Fremah. "The prevalence of HPV-positive Oropharyngeal squamous cell carcinoma at one of the largest tertiary care centers in Sub-Saharan Africa Tygerberg Hospital." University of the Western Cape, 2004. http://hdl.handle.net/11394/8145.
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Magister Chirurgiae Dentium (MChD)CONTEXT Limited data on the prevalence of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) in Sub-Saharan Africa exist. The aim of the current study was to determine the prevalence of HPV-positive OPSCC at one of the largest tertiary care centers in the region (Tygerberg Hospital, Cape Town, South Africa). METHODS Sequential surgical samples of 266 cases of OPSCC diagnosed over a 10-year period (2007-2017) were selected for evaluation and relevant patient characteristics were documented. p16 immunohistochemistry (IHC) was performed as a screening test. All p16 positive cases were further evaluated for HR-HPV using BD onclarity™ HPV assay (BD Diagnostics, Sparks, USA), a real-time PCR assay that detects type-specific E6 and E7 genomic DNA. RESULTS Of 266 OPSCC cases, 14% (n=36) were positive for p16. Of those p16-positive cases, 23 were negative and 13 (13/266=5%) were positive for HR-HPV when evaluated by PCR. P16 was found to have a positive predictive value (PPV) of only 36.1%. HPV subtypes were HPV-16 (n=10), HPV-18 (n=1), HPV-52 (n=1) and HPV-31 (n=1). One case was positive for HPV-16 and HPV-31. HPV-positive OPSCC occurred in 10 men and 3 women (male: female ratio 3.3:1) with a mean age of 51 years (range: 33 to 72 years). All HPV-positive OPSCC arose from the tonsil (n=10) and base of tongue (n=3). Most HPV-positive OPSCC were non-keratinizing (n=10) or partially keratinizing (n=1). In contrast, HPV-negative OPSCC were predominantly keratinizing (n=218). A positive history of smoking was significantly correlated with a negative HPV status (p=0.08) CONCLUSIONS The presence of HR-HPV in 5% of OPSCC cases, in one of the largest tertiary care centers in Sub-Saharan Africa (Tygerberg Hospital), suggests HR-HPV as a minor etiologic agent in OPSCC in this region. Due to its sub-optimal positive predictive value (36.1%), p16 IHC is a less reliable marker for HR-HPV infection due to high incidence of tobacco and alcohol related diseases in this region. When positive, HPV-specific testing should be performed by one of the available platforms. The identification of the less common HR-HPV types; HPV-52 and HPV-31, in our cohort of HPV-positive OPSCC cases, may have implications for in-situ hybridization (ISH) HPV cocktails and current local vaccination strategies.
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Thadani, Acosta Alvaro. "Análisis de la interacción entre el ARN genómico de VIH-1 y proteínas lectoras de N6-metiladenosina (m6A) mediante hibridización in situ acoplada al ensayo de ligación proximal (ISH-PLA)." Tesis, Universidad de Chile, 2018. http://repositorio.uchile.cl/handle/2250/151834.
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Título de Ingeniero en Biotecnología Molecular.La epitranscriptomica es considerada una nueva rama de las ciencias biológicas que tiene como finalidad comprender la regulación de la expresión génica mediada por modificaciones químicas en el ARN. La N6-metiladenosina o m6A, es la modificación interna más abundante descrita en los ARNm. Los miembros de la familia de proteínas YTH han sido descritos como los principales encargados de reconocer la m6A presente en los ARNm y de ejecutar su función. Así, estas proteínas son conocidas como “lectoras” de m6A. En la familia de proteínas YTH existen 5 proteínas de las cuales 4 son citoplasmáticas, (YTHDF1, YTHDF2, YTHDF3 e YTHDC2) y una nuclear (YTHDC1). Mientras las proteínas citoplásmicas han sido asociadas con la regulación de la estabilidad, traducción o degradación de los ARNm que poseen m6A, el quinto miembro es nuclear y está involucrada con los procesos de corte y empalme alternativo y la exportación nuclear de ARNm metilados. Debido a que en los últimos años se ha descrito la presencia de m6A en ARNm virales, como es el caso de VIH-1, es que ha surgido el estudio de la epitranscriptómica viral, campo donde es necesario investigar las funciones de las proteínas involucradas. En este contexto, existen datos controversiales en donde se ha reportado que YTHDF1, YTHDF2 e YTHDF3 promueven la expresión génica de VIH-1 mediante el aumento de ARNm viral en las células infectadas e inhiben las etapas tempranas de la infección al inducir la degradación del genoma viral. Sin embargo, aún se desconoce si YTHDC1 o YTHDC2 regulan alguna etapa de la replicación de VIH-1. En este trabajo se planteó determinar la localización y proximidad entre las proteínas lectoras de m6A y el ARNm de VIH-1 a través de hibridación in situ acoplada al ensayo xiii de ligación proximal (ISH-PLA), de las cuales se obtuvo como resultado que YTHDC1 e YTHDF1 interactúan con el ARNm de VIH-1 en la periferia nuclear y región citoplasmática, respectivamente. Mientras que en el caso de YTHDF2 e YTHDF3, las interacciones observadas, no nos permitieron determinar la localización exacta de estas, mediante ISH-PLA. Una vez determinado esto, se escogió la proteína YTHDC1 como objeto de estudio. Se determinó el efecto de la sobreexpresión de esta lectora de m6A en la expresión génica viral analizando los niveles de la poliproteína Gag mediante Western blot y del ARN genómico mediante RT-qPCR. Aunque no se obtuvo consistencia en los resultados obtenidos, estos sugieren que YTHDC1 posiblemente promueve la exportación nuclear del ARN genómico de VIH-1.
The epitranscriptome is consider a new Branch of biology sciences that aims to understand the regulation of gene expression by chemical modifications on the RNA. The N6-methyladenosine or m6A, it is the most abundant inter modification described on the mRNA. The members of YTH proteins family have been described as the main responsible for recognizing m6A present on the mRNA and execute its function. So, these proteins are known as “readers” of m6A. In the YTH protein family exist 5 proteins of which 4 are cytoplasmic, (YTHDF1, YTHDF2, YTHDF3 e YTHDC2) and one nuclear (YTHDC1). Meanwhile cytoplasmic proteins have been associated with the stability regulation, translation or degradation of mRNA that m6A possesses, the fifth member is nuclear and is involved in the alternative splicing and the methylated mRNA nuclear export. xiv Because the presence of m6A on viral mRNA has been described in recent years, as in the case of HIV-1, the study of viral epitranscriptome has arisen, a field where it is necessary to investigate the functions of proteins involved. In this context, there are controversial data in where it has been reported that YTHDF1, YTHDF2 and YTHDF3 promote HIV-1 genetic expression by increasing viral mRNA in the infected cells and inhibit the early stage of infection by inducing the degradation of viral genome. However, it is still unknow if YTHDC1 or YTHDC2 regulate any stage of HIV-1 replication. In this work planned to determine the location and proximity among m6A reading proteins and HIV-1 mRNA by in situ hybridization coupled to the proximal ligation assay (ISH-PLA), from which YTHDC1 was obtained as a result and YTHDF1 interact with HIV-1 mRNA in the nuclear periphery and cytoplasmic region, respectively. While in the case of YTHDF2 and YTHDF3, the observed interactions did not allow us to determine the exact location of these, through ISH-PLA. Once it was determined, the YTHDC1 protein was chosen as the object of study. The effect of overexpression of this m6A reader in viral genetic expression was determined by analyzing the Gag polyprotein and genomic RNA by Western blot and RT-qPCR. Although no consistency was obtained in the results obtained, these suggest that YTHDC1 possibility promote the nuclear export of HIV-1 genomic RNA.
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Johansson, Anneli, and Vlora Uka. "Varför miljöcertifiera företag?" Thesis, Karlstad University, Faculty of Economic Sciences, Communication and IT, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-3532.
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Företagens tillämpning av miljöledningssystemet ISO 14001 har sedan etableringen år 1994 fram till idag gradvist stegrat. Miljöfrågor får allt mer uppmärksamhet av allmänheten, samtidigt ställs det krav på företag om att de ska driva sin verksamhet utifrån ett miljövänligt perspektiv.
Miljöledningssystemet ISO 14001 är en internationellt känd standard och förekommer oftare bland företag som innehar en certifiering. Investering av ett miljöledningssystem för med sig stora kostnader och företaget förväntas arbeta mycket och tillsammans för att få det att fungera väl. Det finns företag som driver sin verksamhet samtidigt som de tar hänsyn till miljön, men det är först när företag använder sig av ett miljöledningssystem som deras miljöarbete får betydelse. Det kan förklaras med den extra post som tillkommer; miljörevision. Det innebär att företagets miljöarbete granskas av externa revisorer. De ser till att ständiga förbättringar genomförs och att miljötänkandet regelbundet finns i företagets processer. Miljöledningssystemet hjälper företaget att få bättre struktur på sin verksamhet genom dokumentation. Denna dokumentation leder till ökad kontroll, effektivare resursanvändning och underlättar för den nyanställda att komma in i arbetet.
Föreliggande undersökning fokuserar på företag som är etablerade i Karlstad och som har miljöledningssystemet ISO 14001. Undersökningen inkluderar sammanlagt sju intervjuer med miljösamordnare på företagen. Resultaten av undersökning visar att företag miljöcertifierar sig främst i syfte att tillfredställa intressenternas krav och för deras verksamhets fortsatta existens, den egna viljan har alltså väldigt liten inverkan. Trots att investeringen kräver mycket av personalen och kostar en del är det lönsamt eftersom intressenterna är viktiga för företagets fortlevnad. Om miljöledningssystemet bidragit till förändrad kundtillströmning, resultat och ställning är det enligt företagen svårt att mäta. Dock spekuleras det om att miljöledningssystemet har varit positivt för företagets helhetsbild vilket också har påverkan på kundtillströmningen. Samhället förändras mer eller mindre ständigt vilket i många fall har inverkan på företagen, en förändring såsom exempelvis lågkonjunkturen idag påstår de deltagande företagen att det inte kommer att påverka nuvarande miljöarbetet negativt. Miljöarbetet är något som får kosta trots sämre tider.
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Camargo-Pardo, Javier-Andrés. "Systèmes injectables biodégradables pour la libération prolongée d'ivermectine." Thesis, Nancy 1, 2010. http://www.theses.fr/2010NAN10068/document.
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Des systèmes injectables de formation in situ ont été utilisés dans les dernières années pour l'obtention de formulations de préparation facile et permettant la libération prolongée de principes actifs. Ces systèmes utilisant des solvants biocompatibles et des polymères biodégradables sont des liquides (solutions ou émulsions) qui une fois injectés dans l'organisme donnent lieu à des implants (ISI) ou à des microparticules (ISM) solides. La formation de ces systèmes est induite par la précipitation du polymère à partir des solutions polymériques qu'ils contiennent lors du contact avec les fluides corporaux aqueux. Dans ce travail, des ISI et des ISM, réalisés à partir des polymères de l'acide lactique et/ou glycolique (PLA et PLGA) et des différents solvants biocompatibles, pour la libération prolongée d?ivermectine (IVM), un principe actif antiparasitaire faiblement biodisponible par la voie orale, ont été développés. Les profils de libération du principe actif in vitro et in vivo à partir de ces systèmes, ont été comparés avec ceux obtenus à partir de microparticules réalisées par la méthode classique dite d'émulsion simple - évaporation de solvant ; il s'agit d'une technique aux multiples étapes, à coût élevé et dont l'utilisation de solvants toxiques la font difficilement industrialisable. La libération du principe actif à partir des microparticules obtenues par émulsion simple/évaporation du solvant a été influencée par la forte interaction du principe actif avec les polymères mais aussi par la porosité. Dans le cas des systèmes in situ, la vitesse de libération d'IVM a été conditionnée par la solubilité dans l'eau du solvant biocompatible sélectionné et par les interactions solvant/polymère. Pour les ISM, des paramètres tels que la nature de la phase externe, aqueuse (ISM-O/W) ou huileuse (ISM-O/O), la solubilité dans l'eau du solvant de la phase interne, l'affinité entre les phases et l'affinité de l'IVM pour chacune des phases, ont déterminé la vitesse de libération du principe actif. La bonne stabilité ainsi que les profils de libération plus prolongés et présentant une faible libération initiale du principe actif in vivo et in vitro, ont montré que les ISI et les ISM réalisés à partir de solvants biocompatibles de faible solubilité dans l'eau tels que la triacetine sont les plus indiqués pour l'encapsulation d'IVM par rapport à ceux plus solubles dans l'eau comme la N-methyl-2-pyrrolidone et la 2-pyrrolidone. Ces systèmes représentent donc une alternative intéressante par rapport aux formulations conventionnelles d'IVMIn situ forming injectable systems have been used in the past years to obtain sustained drug release formulations which are easy to prepare. These systems using biocompatible solvents and biodegradable polymers are liquids (solutions or emulsions) that upon injection on the body lead to solid implants (ISI) or microparticles (ISM). These systems are formed in contact with water body fluids by polymer precipitation from the polymeric solution. In this work, ISI and ISM made from lactide and/or glycolide polymers (PLA and PLGA) and different biocompatible solvents were performed to obtain sustained release of ivermectin (IVM), an antiparasitic drug with a low oral bioavailability. In vitro and in vivo drug release profiles from these systems were compared with those from microparticles obtained by the classical simple emulsion/solvent evaporation method, which is difficult to propose in industry because of its multiple steps, high cost and the solvent toxicity. Drug release from simple emulsion/solvent evaporation microparticles was affected by the strong polymer/drug interactions and porosity. Concerning to in situ forming systems, the rate of IVM release was dependent on solvent water solubility and solvent/polymer interactions. The nature of the external phase, water (ISM-O/W) or oil (ISM-O/O), the water solubility of the solvent in the internal phase, phase affinity and IVM/phase affinity determined drug release from ISM. The good stability, the in vitro and in vivo sustained release and the low burst effect of IVM, indicated that ISI and ISM formulated from low hydrosoluble biocompatible solvents such as triacetin are more appropriated to IVM formulation instead of those based on more hydrophilic solvent (N-methyl-2-pyrrolidone and 2-pyrrolidone). These systems are an interesting alternative to conventional IVM formulations
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Beristain, Beristain Cecilia. "Ich sage "ich"." Diss., Ludwig-Maximilians-Universität München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-183938.
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In der vorliegenden Arbeit untersuche ich verschiedene Funktionen, die das Wort 'Ich' in unserer Sprache einnehmen. In der Alltagssprache sprechen wir in vielen verschiedenen Weisen und Situationen über uns selbst. Dies ist verbunden mit verschiedenen Verwendungsweisen des Pronomens der ersten Person, das verschiedene Rollen in unserer Sprache haben kann. Wittgensteins Spätphilosophie ist bestrebt diese Rollen zu beschreiben. Dazu beobachtet Wittgenstein den Gebrauch der Alltagssprache.
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Bruhn, Elisa [Verfasser]. "Virtual Internationalization in Higher Education / Elisa Bruhn." Bielefeld : wbv Media, 2020. http://wbv.de/ihs.
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Beard, Rebecca. "'Ich schreibe [...] auf ein Förderband: Ich Ich Ich' : constructing authorship in the work of Günter Grass." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425420.
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Vesik, Hanne. "Isa." Thesis, Linnéuniversitetet, Institutionen för film och litteratur (IFL), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-84762.
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Del av en påbörjad roman om en kvinna som flyttar in i sin avlidna mormors hus efter att ha varit bosatt i London under några år. Hon återupptar kontakten med människor som hon kände som barn, samt reflekterar över tillvaron och ser tillbaka på tiden i London där hon bland annat hade en kärleksrelation som möjligen inte är helt avslutad.
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Knaus, Gudrun. "Ich sammle." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-111384.
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Ob Kunstmuseum oder ethnographische Sammlung, ob Militärhistorisches Museum oder Münzkabinett: In einem vielfältigen Angebotsspektrum ringen große und kleine Museen um die Gunst der Besucher. Die Struktur des Zielpublikums ist dabei in der Regel sehr weit gefasst, da im Sinne des Bildungsauftrags möglichst viele soziale Milieus oder Altersgruppen angesprochen werden sollen. Das Informationsmaterial zur Vermittlung der Ausstellungsinhalte, wie Ausstellungskataloge, Audioguides, Flyer oder der Internetauftritt der jeweiligen Institutionen, enthält eine Vielzahl von weiterführenden Informationen, die in der Regel nur teilweise zielgruppenspezifisch aufbereitet werden, da die Adressaten jeweils nur schwer eingegrenzt werden können. (...)
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Sanmartín, Méndez Luz Del Carmen, and María Teresa Valdés. "Isa Bags." Tesis, Universidad de Chile, 2018. http://repositorio.uchile.cl/handle/2250/168315.
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TESIS PARA OPTAR AL GRADO DE MAGÍSTER EN MARKETINGSanmartín Méndez, Luz Del Carmen, [Parte I], Valdés, María Teresa, [Parte II]
El presente plan de marketing fue desarrollado con el objetivo de posicionar las nuevas bolsas de tela ecológicas Isa Bags en la mente de nuestro mercado objetivo. El plan se ejecutará durante un año iniciando en enero de 2018 y finalizando en diciembre del mismo año. En este plan se plantean las diferentes actividades a realizarse para lograr el objetivo principal y se explica el razonamiento detrás de cada una. De igual manera, se comparte información sobre el entorno y ambiente actual, sobre la industria y fortalezas del producto. Este plan de marketing surge después de haber realizado estudios cualitativos, incluyendo encuestas y entrevistas, para conocer la percepción de los consumidores en nuestro mercado objetivo. Dentro del estudio se tomó en consideración la opinión general sobre el cuidado del medio ambiente para entender como esta impacta su elección de tipo de bolsa, considerando que las Isa Bags son bolsas de tela fabricadas artesanalmente con materiales que no contaminan el ambiente. Se reconocieron segmentos importantes antes de identificar nuestro mercado objetivo y enfocarnos en este para el desarrollo del plan.
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Daly, J. N. "IgH allelic exclusion at the level of IgH transcription." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598257.
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Expression of a productivity rearranged immunoglobulin heavy (μH) chain from a first in-frame VDJH-rearranged allele prevents further recombinant of the second, DJH-rearranged, allele, termed heavy chain allelic exclusion. I investigated at the single cell level the transcriptional status of both IgH alleles in ex vivo cells using RNA fluorescent in situ hybridisation (FISH). Prior to exclusion, in predominantly DJH /DJH-rearranged pro/pre-B1 cells, both IgH alleles are transcribed and detected by RNA-FISH. In contrast, following productive VDJH-recombination and μH expression i.e. in allelically excluded pre-BII cells, mono-allele transcription was detected in the 40% and bi-allelic in 60% of cells. This 40:60 ratio was maintained throughout subsequent B cell developmental stages. A VH-specific transcription assay revealed a VH (J558) transcription co-localising with mono- and bi-allelic μ transcription sites, strongly indicating transcription from VDJH-rearranged alleles in allelically excluded B cells. Combined RNA/DNA FISH showed detection of the VH-DH intergenic regions in cells with mono-allelic μ-transcription. Within these nuclei the μ-transcription site and VH-DH intergenic region were clearly separate and thus do not originate from the same allele, thus suggesting a VDJH/DJH-rearrangement status. In the majority (>80%) of nuclei with two μ-transcription sites no VH-DH-intergenic regions were observed, suggesting VDJH/VDJH-recombination. Semi-quantitative RT-PCR revealed steady-state DJH-Cμ transcripts in splenic B cells, which have been allelically excluded at levels 2-3 fold less than observed in a developmental stage prior to exclusion. Thus the DJH-recombined allele is transcribed after exclusion. Our data show that the process of allelic exclusion results in diminished ability for RNA-FISH to detect the transcription of the DJH- but not the VDJH-rearranged alleles, indicating that the signal for allelic exclusion is received only by the DHJ-recombined alleles. Therefore, in allelically excluded cells, the DJH-but not VDJH-rearranged alleles alter their transcriptional activity and thus act as part of the mechanism for heavy chain allelic exclusion.
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Peroutka, Tomáš. "Integrace ISMS/ISO 27001/ISO 27002 do společnosti RWE." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-114299.
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The main theme of this diploma thesis is Information Security Management System (ISMS) which is based on security standard ISO 27001 and ISO 27002. This thesis is one part of the project of integration ISMS to company RWE. First goal is analysis of actual documentation of RWE. Second goal is proposal of ideal structure of ISMS documentation. Third goal is assignment the parts of RWE documentation to ideal structure of ISMS documentation. Analysis of actual documentation used knowledge about RWE documentation to create overview table with all documents and their relations. Ideal structure of ISMS documentation was based on selected parts of ISO 27001 and multicriterial analysis. Third goal of this thesis was reached by assignment parts of RWE documentation to selected parts of ISO 27001 from the second goal. Contribution of this diploma thesis is the ideal structure of ISMS documentation and form of old RWE documentation assignment, because these goals are usual steps of PDCA cycle of ISMS but they are described briefly and sparsely in security standards and works related to ISMS.
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Bomark, Niklas. "Involvement in ISO 14001 : ISO 14001 from a user perspective." Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-155746.
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Today the ISO 14001 system is used within a rather wide spectrum of firms and industries, even if the early adopters of the standard mainly where organizations in the heavy industry and manufacturing sectors (Peglaue and Baxter, 2007). Many of those early adopters have now been certified for over 10 years, and during the years several surveys and case studies have been conducted to pinpoint the motives, benefits and challenges for why organizations chose to implement and maintain the system (Massoud, 2010; Jiang and Bansal, 2003). However, one issue with research about ISO 14001 up until now is that most studies have focused upon a managerial perspective where the managers´ attitudes have been in focus rather than the employees (Boiral, 2007). Therefore, this case study set out to explore how the employees, the production operators, inside one certified organization are involved in ISO 14001 through a Grounded Theory approach. The results of the study showed that the production operators relied upon different strategies in order to legitimize their involvement in ISO 14001. Further on, the study shows that the production operators where involved in ISO 14001 at a level which was required in order to keep the certification. However, they could not obtain enough legitimacy to motivate an involvement in ISO 14001 which extended what was required in order to keep the certification. Grounded in the discovery of the different strategies used by the employees, this study argues that environmental awareness could be seen as an internal barrier and as a source for unsatisfied employees. Something which risks emphasizes a feeling of being involved in a rational myth (Boiral, 2007).
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Kahrle, Atterlord Naomi. "Framgångsfaktorer för etablering av ledningssystemstandarderna ISO 14001 och ISO 39001." Thesis, Linnéuniversitetet, Institutionen för biologi och miljö (BOM), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-27393.
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Standarder för ledningssystem är ett hjälpmedel för företag och myndigheter att bedriva arbete i en viss fråga. Spridningen och etableringen av ledningssystemstandarder är beroende av flera faktorer. I och med lanseringen av det nya ledningssystemet för trafiksäkerhet, ISO 39001, vill Trafikverket förstå vilka framgångsfaktorer som finns för ett väletablerat ledningssystem. Detta görs genom att utvärdera ett ledningssystem som har kommit att få god global spridning och etablering, miljöledningssystemet ISO 14001. Syftet med denna uppsats är att utreda vilka framgångsfaktorerna är för etableringen och spridningen av miljöledningssystemet, ISO 14001, för att sedan se om dessa går att applicera på trafiksäkerhetsledningssystemet, ISO 39001. För att besvara detta genomfördes en litteraturstudie som kompletterades med en empirisk undersökning. Den empiriska undersökningen utgjordes av semistrukturerade intervjuer som genomfördes med fyra aktörer med god kännedom om den nya trafiksäkerhetsstandarden. Uppsatsen visade att de framgångsfaktorerna som kan relateras starkast till ISO 14001 är dess koppling till ISO 9001, den rådande tidsandan samt fördelar som ökade marknadsandelar genom god publicitet vid certifiering. De krav som ställdes på underleverantörer från redan certifierade företag är också en betydande faktor. Även om trafiksäkerhet fått större utrymme på världsagendan under senare år var inte trafiksäkerhetsengagemanget lika stort vid lanseringen av ISO 39001 som miljöengagemanget var vid lanseringen av ISO 14001. Spridningen av ISO 39001 beror även på regeringsstöd, med förhoppning om att den införs i lagstiftningen då nollvisionen är ett riksdagsbeslut. Den offentliga sektorn tog initiativ till arbetet med ISO 39001 och efterfrågan kan bidra till att ISO 39001 når stora framgångar inom den offentliga sektorn. ISO 39001 har föregåtts av en nollvision och en nationell branschspecifik säkerhetsstandard som har banat vägen för standarden inom vissa sektorer. De verksamheter som inför ISO 39001 kommer troligtvis göra detta för att uppfylla marknadskrav och myndighetskrav. En viktig framgångsfaktor för ISO 39001 är att den ger förutsättningar för företag att ställa krav på sina underleverantörer, något som bekräftades vid intervjuerna.
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Krebs, Sandra. "Identitätskonstitution in Wilhelm Raabes Ich-Romanen Ich-Spiegelungen und Erzählprozess." Hamburg Kovač, 2008. http://d-nb.info/993077048/04.
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Fingal, Charlotte, and Sara Ahmad. "ISO 14001 - Hinder eller möjligheter ISO 14001 - Obstacles or oppotunities." Thesis, Malmö högskola, Fakulteten för teknik och samhälle (TS), 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-21476.
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Arbetet med miljöfrågorna är svåra att strukturera och därför har olika internationella miljöstandarder skapats. SS-EN ISO 14000 är en serie internationella miljöstandarder, som i dagligt tal kallas ISO 14000 och i denna standard ingår ISO 14001 vilken kan användas som grund vid uppbyggandet av ett miljöledningssystem och det är införandet av denna som analysen vilar på. Syftet med uppsatsen är att undersöka vilka hinder som kan uppstå vid införandet av ISO 14001-standarden. Även att identifiera vilka lösningar som finns att tillgå gällande hindren. Dessutom utforskas vilka de olika incitamenten är som driver en verksamhet till att vilja integrera miljöfrågor bland övriga beslut. Slutligen granskas fördelar med att införa miljöledningssystemet ISO 14001.
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Baraya, Raghda, and Johansson Malin. "Implementeringen av ISA." Thesis, Södertörns högskola, Institutionen för samhällsvetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-26285.
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Syftet med denna studie ä̈r att undersö̈ka hur infö̈randet av den nya revisionsstandarden ISA upplevs av revisorerna i Sverige och hur ISA fö̈rhåller sig till god redovisningssed och rättvisande bild.
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Garaffini, Eliana Vanina. "Normas ISO 9001." Bachelor's thesis, Universidad Nacional de Cuyo. Facultad de Ciencias Económicas, 2015. http://bdigital.uncu.edu.ar/7528.
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Könemann, Judith. ""Ich wünschte, ich wäre gläubig, glaub' ich : Zugänge zu Religion und Religiosität in der Lebensführung der späten MModerne /." Opladen : Leske + Budrich, 2002. http://catalogue.bnf.fr/ark:/12148/cb38883887b.
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Vaičiūnaitė, Raimonda. "Statybos įmonės veiklos valdymas įdiegus ISO 9000 ir ISO 14000 standartus." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20080925_115102-41434.
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Magistro darbe nagrinėjamas statybinės įmonės veiklos valdymas įdiegus kokybės ir aplinkos apsaugos vadybos standartus, išaiškinamos ISO 9000 serijos standarto kokybės vadybos sistemų diegimo problemos visuotinės kokybės vadybos atžvilgiu. Išsamiai analizuojami vadybos sistemų integravimo ypatumai, kokybės ISO 9000 ir aplinkos apsaugos ISO 14000 vadybos sistemos standartų reikalavimai bei juos įtakojantys veiksniai, kokybės bei aplinkosaugos sistemų naudą įmonėje. Teoriniai sprendimai pagrįsti: Abramavičiaus Š., Adomėno V., Jucevičiaus R., Paulauskaitės N., Rutkausko J., Vanago P., Gardin D., Hoyle D., Tsiakals J., West J. bei kitų autorių moksliniais straipsniais ir knygomis, kuriose teoriniais aspektais analizuojamos ISO 9000 serijos standarto kokybės vadybos sistemų diegimo problemos, vadybos sistemų integravimo ypatumai, Aplinkos vadybos sistemų diegimas Lietuvos įmonėse. Atlikta anketinė apklausa, siekiant identifikuoti įmonės veiklos valdymą įdiegus kokybės ir aplinkos apsaugos vadybos sistemas. Patvirtinama autorės suformuluota mokslinio tyrimo hipotezė, kad VKV – į kokybę orientuotas UAB „NCC titanas“ vadovavimo būdas, pagrįstas visų jos narių dalyvavimu, siekiant ilgalaikės sėkmės tenkinant klientą ir naudos visiems savo organizacijos nariams bei visuomenei. Tačiau visgi UAB „NCC titanas“ reiktų didesnį dėmesį skirti paslaugų ir darbuotojų veiklos kokybės gerinimui, VKV žinių tobulinimui, komunikavimo procesui bei vidinių ir išorinių klientų lūkesčių tenkinimui.This work analyses the practice of constructional enterprise administration after introducing into it the quality and anti-pollution standards, also the problems of ISO 9000 quality of standard management system implemention regard to general quality management. The management system integration peculiarities are analysed as well as the requirements for quality of ISO 9000 series and anti-pollution ISO 14000 series management system standarts, factors that influence them, quality and anti-pollution systems benefit in enterprise. Theoretical decisions are based on: Abramavičius Š., Adomėnas V., Jucevičius R., Paulauskaitė N., Rutkauskas J., Vanagas P., Gardin D., Hoyle D., Tsiakals J., West J. and other authors memoirs and books in which the ISO 9000 series quality standards of management systems implemention problems and pecularities, anti-pollution management system installation in Lithuania companies and so on are analysed by theoretical aspects. The survey was made by seeking to identify the administration of enterprise after implemention of quality and anti-pollution management systems. The hypothesis of author that the style of leadership TQM, which is oriented to JSC „NCC titanas“ and based on participation of all members, trying to reach permanent success to meet the requirements of customer and get a big benefit for all members of organization and society was confirmed. Though still JSC „NCC titanas“ should pay more attention to development of the service and the... [to full text]
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Wei, Weixiao. "ISP copyright liability : towards an enhanced Chinese ISP copyright liability regime." Thesis, University of Strathclyde, 2009. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=11856.
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ISP copyright liability for copyright infringement over the Internet is a now widely adopted approach for tackling extensive online copyright piracy in various jurisdictions. However, in China, the inconsistent ISP knowledge standard and the lack of peer-to-peer file-sharing liability provisions in the existing legal framework are among the factors that impede effective copyright law enforcement on the Internet. The adoption of a broad knowledge standard and its application in case law, both in the U.S. and Germany, which have great influence on a Chinese ISP copyright liability system, are discussed along with a similar knowledge standard provided by the Chinese Online Copyright Regulations and its application to ultimately show the need of a broad knowledge standard in a Chinese ISP copyright liability system. As for the liability issues over peer-to-peer file-sharing networks, analysis of several prominent cases and the enacted or proposed legislation in this regard in an international context sheds light on the importance of a filtering mandate in effectively deterring copyright piracy. In a Chinese context, the absence of peer-to-peer file-sharing liability legislation and the inadequacy of the applied provisions in the existing legislation entail the examination of the need and the possibility of the mandatory use of filters in a Chinese ISP copyright liability system. For an enhanced Chinese ISP copyright liability regime, the thesis concludes with two recommendations that a broad ISP knowledge standard should be retained in the Chinese ISP copyright liability system and a filtering mandate is needed and should be legislated for efforts against widespread unlawful peer-to-peer file-sharing.
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Tomahoghová, Jana. "Manažment dlhovej krízy: aktéri, ich schopnosti a možnosti konania, ich stratégie." Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-191945.
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Debt crisis is seen as a spiral which has been launched by failure of American financial market and which final stage is global economic depression. But we can not speak only about financial market crisis. Current world crisis is at the same time political crisis and social crisis; it is a multi-sector crisis. Actors which try to manage the crisis, their abilities, possibilities to act and their strategies in each sector will be identified and described in the thesis. Complexity of current crisis demands global solutions involving cooperation of different actors throughout all three mentioned sectors.
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Ackelman, Jenny. "Alternative splicing and its regulation under normal and abnormal conditions." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-56899.
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Eisele, Sandra Fischinger Sylvie. "Ich arbeite, also bin ich! Ich arbeite nicht, also...? Analyse vom Bild der Erwerbsarbeit und Erwerbslosigkeit aus Sicht langzeiterwerbsloser Personen." Rubigen Bern Ed. Soziothek, 2005. http://www.soziothek.ch/?3-03796-110-4.
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Kicmari, Ruzhdi [Verfasser]. "„Ich spreche Deutsch, ich denke aber Albanisch“: Deutsch-albanische Sprachbiographien / Ruzhdi Kicmari." Hamburg : disserta Verlag, 2020. http://d-nb.info/1222208067/34.
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Duarte, Alexandra Silva. "Transição da norma ISO 9001:2008 para a norma ISO 9001:2015." Master's thesis, Instituto Superior de Economia e Gestão, 2018. http://hdl.handle.net/10400.5/16639.
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Mestrado em Gestão e Estratégia IndustrialAs organizações implementam cada vez mais os padrões de gestão desenvolvidos pela International Organization for Standardization (ISO) para se manterem competitivas. Ao longo dos anos, a investigação na área da certificação da qualidade pela norma ISO 9001 tem vindo a aumentar. No entanto, ainda existem poucos estudos que abordam as transições da norma, particularmente da norma ISO 9001:2008 para a norma ISO 9001:2015. Com base em 356 respostas recolhidas através de um questionário enviado via e-mail para as empresas portuguesas certificadas pela norma ISO 9001, procedeu-se à análise da perceção das empresas em relação à transição para a norma ISO 9001:2015. A importância atribuída às alterações recentes da norma ISO 9001 variam consoante a dimensão da empresa, a estratégia de internacionalização e o tipo de indústria onde a empresa opera. Os resultados obtidos mostram ainda que as melhorias organizacionais internas, a melhoria da satisfação dos clientes, a melhoria da imagem da empresa e a melhoria da qualidade do produto/serviço são as principais motivações, segundo a perceção dos gestores, da implementação da norma ISO 9001. E mostram também que os principais benefícios, segundo a perceção dos gestores, da implementação da norma ISO 9001 são a melhoria contínua do desempenho, o aumento do prestígio e reputação da empresa, a melhoria da eficiência dos processos e o aumento da satisfação dos clientes.
The organizations are increasingly implementing the management standards developed by the International Organization for Standardization (ISO) in order to remain competitive. Over the years, research into quality certification of ISO 9001 has been increasing greatly. However, there are still few studies that address the transitions of the standard, particularly from ISO 9001:2008 to ISO 9001:2015. Based on the 356 replies collected by a questionnaire, which was sent by e-mail to the portuguese companies certified by ISO 9001, this study analyze their perception regarding the transition to the ISO 9001:2015. The importance attributed to the recent changes in ISO 9001 vary according to the size of the company, the internationalization strategy and the type of industry where the company operates. The results obtained also show that internal organizational improvements, improvement of customer satisfaction, improvement of company image and improvement of product/service quality are the main motivations according to the perception of managers of the implementation of ISO 9001. And also show that the main benefits, according to the perception of managers, the implementation of ISO 9001 are the continual improvement of performance, increase the prestige and reputation of the company, improving process efficiency and increased customer satisfaction.
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Dreyer, Florian. "Siremobil Iso–C 3D." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-84344.
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Kim, Oh-Hyun. "Ich, Freiheit und Moral /." Frankfurt am Main : P. Lang, Europäischer Verl. der Wissenschaften, 1996. http://catalogue.bnf.fr/ark:/12148/cb37095409m.
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Liu, Tong. "„Ich verstehe nur Chinesisch!“." Doctoral thesis, Humboldt-Universität zu Berlin, Philosophische Fakultät II, 2015. http://dx.doi.org/10.18452/17269.
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Vor dem Hintergrund der Ausspracheabweichungen, die chinesische Muttersprachler beim Erwerb der deutschen Aussprache produzieren bzw. aufweisen, widmet sich die vorliegende Arbeit einer intensiven kontrastiven phonetisch-phonologischen Analyse des Deutschen (Standardbinnendeutsch) und des Chinesischen (Putonghua) auf der segmentalphonetischen und -phonologischen, der phonotaktischen und der suprasegmentalen Ebene, um hierauf aufbauend internetbasierte Lehr- und Lernmaterialien zur deutschen Aussprache für chinesische Muttersprachler zu entwickeln. Exemplarisch für diese Konzeption stehen zwei zweieinhalb- bis dreiminütige selbst entwickelte und professionell ausgearbeitete Lernvideos (zu den deutschen Kurz- und Langvokalen sowie zu Konsonantenhäufungen).Considering pronunciation deviations which are produced by Chinese native speakers in the learning of German pronunciation, this dissertation conducts an intensive contrastive phonetic-phonological analysis of German (Standard internal German) and Chinese (Putonghua) on the segmental, the phonotactic and the suprasegmental levels, in order to further develop internet-based teaching and learning materials for German pronunciation targeting Chinese native speakers. Two educational videos about German pronunciation for Chinese native speakers based on this contrast are developed as a result of this analysis, with one focusing on German short and long vowels and the other on consonant clusters.
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Leppänen, S. (Samu). "Hirsirakenteinen huoneistohotelli Iso-Syötteelle." Master's thesis, University of Oulu, 2019. http://jultika.oulu.fi/Record/nbnfioulu-201906042326.
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Tiivistelmä. Tämä diplomityö on suunnitelmapainotteinen työ, jonka aiheena on uusi hirsirakenteinen huoneistohotelli Iso-Syötteen laskettelukeskukseen. Suunnitelma on toteutettu osana Moderni Hirsikaupunki -hanketta, joka tutkii nykyaikaisen hirsirakentamisen käyttömahdollisuuksia kaupunkiympäristössä, sen haasteita ja hyötyjä. Diplomityö on tehty syksyn 2018 ja kevään 2019 aikana, Moderni Hirsikaupunki -hankkeen loppupuolen arviointivaiheessa, mutta työn suunnittelullisen aiheen vuoksi se kuuluu varsinaisesti hankkeen suunnittelututkimusvaiheeseen. Suunnittelutyön aihe on saatu Hotelli Iso-Syötteen johtajalta, jonka aikeena on ollut rakentaa laskettelukeskuksen ala-aseman läheisyyteen uusi huoneistohotelli. Toiveena oli tutkia mahdollisuutta toteuttaa suhteellisen suurikokoinen hotellirakennus hirsirakenteisena, mihin tässä diplomityössä onkin tartuttu. Annetut lähtötiedot itse suunnittelulle olivat suhteellisen niukat, sisältäen lähinnä suunnittelualueen suurpiirteisen rajauksen ja toivotun huoneistojen määrän, joten suunnittelussa on otettu paljon vapauksia esimerkiksi muun tilaohjelman sekä arkkitehtuurin suhteen.
Diplomityö jakautuu karkeasti ottaen kolmeen toisiinsa linkittyvään osaan: aiheen taustoitukseen, suunnittelupaikan tutkimiseen, sekä varsinaiseen suunnitelmaosuuteen.
Tausta -osuus on kirjallisena tehty osio, joka antaa suunnitelman kannalta olennaisia taustatietoja aiheeseen liittyen. Taustoituksessa on rrottu lyhyesti Suomen hirsirakentamisesta, sekä esitelty Pohjois-Suomen matkailuarkkitehtuurin historiaa ja pohdittu sen nykytilaa ja tulevaisuutta. Matkailuarkkitehtuuri on 1960-luvulle saakka ollut suhteellisen laadukasta, mutta sen jälkeen massaturismin alettua taso on heikentynyt ja erityisesti Suomen laskettelukeskuksiin on noussut mitä ihmeellisempiä tyylittömiä luomuksia. Eriskummallisella kulissiarkkitehtuurilla pyritään houkuttelemaan turiseja, mutta ehkä samaan lopputulokseen voitaisiin päästä myös oikeasti laadukkaalla arkkitehtuurilla.
Paikka -osuudessa on esitelty tarkemmin suunnittelualuetta, Iso-Syötettä, ja kerrottu sen historiasta ja tulevaisuudesta sekä esitelty nykyistä tilannetta suunnittelun pohjaksi. Iso-Syöte on Pohjois-Pohjanmaalla sijaitseva tunturi, jonka alueen historia ulottuu kivikaudelle asti. 1980-luvulta lähtien tunturilla on toiminut laskettelukeskus Iso-Syöte, jonka toiminta on pyörinyt pääosin menestyksekkäästi tähän päivään saakka. Iso-Syötteen ympäristö ja toiminnot tarjoavat kiinnostavat lähtökohdat diplomityön suunnitteluosuudelle.
Suunnitelma -osuus esittelee diplomityön varsinaisen suunnittelutyön, Hirsirakenteisen huoneistohotellin Iso-Syötteelle. Huoneistohotelli koostuu maantasokerrokseen ja kellariin sijoittuvista julkisista tiloista, kuten ravintolasta, baarista, liiketiloista ja saunatiloista, sekä tilaelementtitekniikalla toteutetuista majoitushuoneistoista kolmessa kerroksessa. Hotellissa on pyritty yhdistelemään klassisen luontomatkailun piirteitä, paikalla vallalla olevaan aktiiviseen laskettelumatkailuun. Suunnitelman lähtökohdat ovat vahvasti kontekstissa ja paikallisuudessa, ja perinteikästä hirsirakentamista on siinä käytetty modernilla tavalla laadukkaan arkkitehtuurin luomiseen.Log-structured apartment hotel for Iso-Syöte. Abstract. This master’s thesis is a design oriented work, whose topic is a design for a new log-structured apartment hotel, for the ski resort of Iso-Syöte. The work is done as a part of the Modern Log City (Moderni Hirsikaupunki) -research project, which studies the potential of log structures in the urban environment; the challenges and the benefits. The master’s thesis has been done during the autumn of 2018 and spring of 2019, during the evaluation period of the Modern Log City -research project, but due to the design oriented character of the work, it is more a part of the design-based research period of the project. The topic of the thesis was given by the manager of the Hotel Iso-Syöte, whose aim has been to build a new apartment hotel close to the bottom of the ski slopes. His request was to study the possibility of constructing a rather extensive hotel building using a log structure, and that is the issue which has been dealt with in this master’s thesis. The given initial data was rather scarce, including essentially the rough boundaries of the design area and the desirable amount of rooms, so a lot of liberties have been taken considering the space programme and architecture for example.
This master’s thesis is coarsely divided into three interlinking parts: the background of the subject, the examination of the site and ultimately the actual project of the apartment hotel.
The background part is a written part, presenting some essential information in relation to the subject. In the background section, the history of log buildings in Finland is being briefly described, as well as the history, present state and the future of the tourism related architecture in northern Finland. The tourism related architecture has been quite high-class until the 1960’s, but after that, since the era of mass tourism, the quality has been decreasing, and run-down architectural creations have emerged throughout the ski resorts in Finland. Odd, counterfeit architecture is being used as a method for attracting tourists, even though the same results could likewise be achieved with some genuine high-quality architecture.
The site part introduces more closely the area of interest, Iso-Syöte, by telling about its history, future and the present state as a grounding for the design work. Iso-Syöte is a fjeld in the North Ostrobothnia, and the area has a history stretching all the way to the Stone Age. Since the 1980’s the Iso-Syöte ski resort has been operating at the fjeld, doing quite successfully to this day. The environment and the activities of the Iso-Syöte provide a truly fascinating starting point for the design phase of the master’s thesis.
The design part presents the actual design work of the master’s thesis, the apartment hotel with a log structure for the ski resort of Iso-Syöte. The apartment hotel consists of some public spaces in the ground floor and basement such as a restaurant, a bar, a public sauna and some commercial spaces, as well as accommodations in three floors, conducted with prefabricated box units. With the design of the hotel, some characteristics of the classical tourism have been introduced to the existing environment of active tourism. The design is strongly based on the context and locality, and the traditional log construction has been used in a modern manner in order to achieve admirable architecture.
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Liu, Lisa M. Eng Massachusetts Institute of Technology. "Portable iso-dielectrophoresis system." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/105981.
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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 60-62).
Iso-dielectrophoresis (IDS) can be used to characterize and separate cells by their electrical characteristics. An IDS system usually consist of a RF frequency voltage source up to 24 V, syringe pumps, microscope, and computer. Much of this equipment is difficult to transport, making off-site sample collection of time-sensitive samples, such as blood, difficult. The miniaturization of the IDS system would allow measurements to take place at the time of sample collection, improving the confidence in the measurement. This thesis details an attempt to miniaturize each system. The Raspberry Pi microcomputer was used to control and process signals from the hardware. A portable, affordable system for the electrical and optical equipment systems are described. A custom PCB was designed to provide voltage signals up to 3 MHz and 12 Vpp. A microscope using a Raspberry Pi camera and reversed webcam lens achieved 240x magnification with 13 [mu]m resolution. Alternatives to the syringe pump, including air pressure regulated pumps and peristaltic pumps, were considered for the fluidic component.
by Lisa Liu.
M. Eng.
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Capella, Fernanda Mathias. "Arquitetura reconfigurável multi-ISA." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/104137.
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O mercado de sistemas embarcados tem demandado uma variada gama de aplicações, aplicações estas cada vez mais complexas. Para atender tal demanda, visto o declínio da lei de Moore e os processadores chegando ao seu limite de dissipação térmica, os projetistas são pressionados a desenvolverem novas organizações computacionais. Para manter a compatibilidade binária, de forma que a grande quantidade de aplicativos e ferramentas já desenvolvidas possa ser reutilizada, as empresas desenvolvem seus produtos focando em melhorias de um dado processador que irá executar a mesma ISA (Instruction Set Architecture). Essa necessidade de compatibilidade de código impõe muitas restrições à equipe de projeto, haja vista as limitações impostas pela ISA legada. A Tradução Binária (TB) abre novas possibilidades aos projetistas, visto que permite a execução de códigos previamente compilados para uma determinada arquitetura em outra arquitetura. No entanto, a TB acrescenta mais uma camada entre o código e sua execução, trazendo perdas de desempenho. Este trabalho explora um novo mecanismo de tradução binária dinâmico de dois níveis que, ao trocar o primeiro nível, pode executar ISAs diferentes de forma totalmente transparente e ainda amortiza os custos de tradução. Da mesma forma ao trocar o segundo nível de tradução binária pode-se trocar a arquitetura alvo. Com base nesse tradutor de dois níveis, é apresentado como estudo de caso um sistema computacional composto por uma arquitetura reconfigurável capaz de executar códigos x86, ARM, PowerPC e MIPS de forma transparente, com compatibilidade binária e com ganhos de desempenho.The embedded systems market is demanding a wide range of applications, and these applications are increasing in complexity. In order to meet this demand, since the decline of Moore’s law and processors reaching their thermal dissipation limits, designers are pushed to develop new computer organizations. In order to support binary compatibility, so that the large quantity of applications and tools already deployed can be reused, companies develop their products focusing on improvement of a given processor that will execute the same ISA (Instruction Set Architecture) as before. This need for code compatibility impose a lot of restrictions to the design team, considering the limitations imposed by the legacy ISA. Binary Translation (BT) open new possibilities for designers, since it allows the execution of a code previously compiled to a specific architecture in another architecture. However, BT adds another layer between code and actual execution, therefore bringing performance penalties. This work explores a dynamic two-level binary translation system that, by changing the first BT level, allows the execution of different ISAs in a transparent fashion and still amortizes translation costs. In the same way, it is possible to switch to another target architecture by only changing the second BT level. Based on this two-level translator this work presents, as a case study, a computational architecture comprising of an dynamic reconfigurable array that can execute x86, ARM, PowerPC and MIPS binary codes in a transparent way, maintaining binary compatibility with performance gains.
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Botkina, Darya, and Meixin Xu. "ISO ToolMaker application development." Thesis, KTH, Industriell produktion, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-201734.
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With the rapid development of manufacturing industry, there is an increasing need for different industries to communicate, exchange and share information. While, the diversity of terms being used among different organizations makes the communication hard to proceed. Due to this reason, Sandvik Coromant decided to initiate development of a new international standard ISO 13399 under the title Cutting tool data representation and exchange. The standardis developed by Sandvik Coromant, KTH Royal Institute of Technology in Stockholm, French Cetim (technical centre for mechanical engineers) and other organizations in the metal cutting sector. (Sandvik Coromant)ISO 13399 has been developed for years, and it has reached a stage to be tested and verified. In 2014, Sandvik starts a new project of developing an application called ISO ToolMaker for verifying and validating the development and implementation specification of ISO 13399. By2016, the framework of this application has been set up. Since the software development is still at the primary stage, there are plenty of issues need to be settled afterwards. Therefore, the purpose of this thesis is to promote the reform of ISO ToolMaker, adjusting existing undesired functions, adding new modules for advanced usage, and reorganize the software structure for continuous improvement. By conducting the literature research and interviewing the staff in Sandvik Coromant, an action plan was made, and a systematic method was applied to guide the procedures. Compare to the previous application, the final version has three significant advantages ‐ an extra store function for items and assemblies, a more rigorous logical connection and a one‐click output mode and, in addition, the text‐info for guiding each step and the detail design of the software. All the aspects make it a superior and user‐friendly application to work with.Med den snabba utvecklingen av industrin finns det ökande behov mellan branscherna att kommunicera, utbyta och dela information. Samtidigt försvårar mångfalden av termer som används mellan olika organisationer kommunikationen. På grund av detta beslutade Sandvik Coromant att initiera utveckling av en ny internationell standard ISO 13399 med titeln Cuttingtool data representation and exchange. Standarden är framtagen av Sandvik Coromant, Kungliga Tekniska högskolan i Stockholm, franska CETIM (tekniskt centrum för maskiningenjörer) och andra organisationer i metallbearbetningssektorn. (Sandvik Coromant) ISO13399 har utvecklats under många år och har nått ett stadium när det ska testas och verifieras. Under 2014 startade Sandvik ett nytt projekt för att utveckla ett verktyg som heter ISO ToolMaker för verifiering och validering av utvecklingen och specifikation för införande av ISO 13399. 2016 hade ramverket för detta verktyg etablerats. Eftersom mjukvaruutveckligen fortfarande är i ett tidigt skede, finns det en hel del frågor som måste lösas i efterhand. Därför är syftet med detta examensarbete att vidareutveckla ISO ToolMaker, genom att förbättra dåliga funktioner, lägga till nya moduler för avancerad användning och omorganisera mjukvarustrukturen för ständiga förbättringar. Som ett resultat av litteraturstudie och intervjuer med personal på Sandvik Coromant togs en handlingsplan fram och en systematisk metod användes för utvecklingsarbetet. Jämför med det tidigare verktyget, har den slutliga versionen tre betydande fördelar ‐ en extra lagringsfunktion för objekt och montage, en mer omfattande logisk sammankoppling och en ”one‐click”‐resultatvisning och dessutom textinfo för att styra varje steg och detaljutvecklingen av mjukvaran. Dessa egenskaper gör det till ett bekvämt och användarvänligt verktyg att arbeta med.
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Romero, Matías Gastón. "Certificación de normas ISO." Bachelor's thesis, Universidad Nacional de Cuyo. Facultad de Ciencias Económicas, 2012. http://bdigital.uncu.edu.ar/5247.
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Es común percibir que, en la empresas pequeñas o que recién comienzan, el mecanismo de control asociado es el de observación directa por parte del propietario. En cambio para las empresas de mayor tamaño, existen mecanismos más sofisticados de control que permiten realizar un registro más profundo de las actividades, su desarrollo y por sobre todo su adecuación con los objetivos de la firma.
Más allá de ser una pequeña o gran empresa, cada una debería implementar un Sistema de Control de Gestión para facilitar el mejoramiento continuo de cada elemento de la organización.
Lecar S.A. es una empresa familiar dedicada a la compra - venta de automotores nuevos y usados en la provincia de Mendoza, que ha sufrido a lo largo de sus años varias modificaciones en su estructura, pero nunca logró establecer un orden formal en sus actividades.
Se podría decir, que un problema desde el punto de vista social, es una dificultad o
impedimento que se interpone para el desarrollo normal de una situación, y por lo tanto requiere de una solución.
Los objetivos de este trabajo se pueden disgregar en uno general que es el de formular y documentar un manual de políticas y procedimientos para las áreas operativas más importantes de Lecar S.A. y otros, un tanto más específicos, como analizar la empresa Lecar S.A. en su estado actual, analizar los beneficios y costos de los manuales de políticas y procedimientos en una empresa familiar, establecer conocimientos generales sobre calidad en la gestión y realizar un acercamiento a los instrumentos de certificación de normas de calidad en la gestión de las empresas.Fil: Romero, Matías Gastón. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.
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Wahlén, Niklas. "On ISP Friendliness: Introducing an ISP-Friendly Peer-to-Peer Live Streaming System." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-100337.
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The various capabilities provided by the Internet have attracted a large amount of Internet-based applications over the last decades. Many services that previously only used other means of communication are now also deployed on the Internet. As the content in the communication becomes richer, the bandwidth required to communicate it increases. In the case of delivering audiovisual content over the Internet, a significant amount of bandwidth is required to send the content to a single recipient, and increases rapidly for each additional recipient. To be able to provide scalable, Internet-based systems for video content delivery, researchers and companies have begun to focus on peer-to-peer-based approaches, meaning participants collaborating and contributing their bandwidth to assure content delivery to all others. This thesis proposes a design for a peer-to-peer system for delivery of live video, and provides simulation results for an implementation of the design. The design targets some of the current issues of peer-to-peer systems – mainly that of providing friendliness towards Internet Service Providers (ISPs). Peer-to-peer systems generate considerable amounts of traffic, which is often sent between peers located in different ISPs, even when data is available at a peer in the same ISP as the recipient. This creates problems for ISPs as they often have to pay other ISPs for data sent over cross-ISP connections, and because congestion can occur in the ISPs gateways to the rest of the Internet – the problems increasing with the number of ISPs that the traffic has to go through. This has forced some ISPs to limit or block peer-to-peer traffic completely. The system designed in this thesis uses a gossip-based peer-to-peer protocol for content dissemination, and to minimize cross-ISP traffic, the thesis proposes that peers should choose peers closer in the network topology to connect to. This can be achieved by creating a database composed of ISPs and the distance between them, which is consulted every time a new connection is to be created. The database is small enough to be stored locally at each peer. As long as a peer is able to deliver a clear stream it will only connect to close peers, however should the close peers not be able to provide data at a sufficient rate, the peer will request random peers in the system to also provide it with data. Evaluation of the system in various simulation scenarios shows that it operates well in a constrained environment as well as during peer failures. The evaluation also shows that it is possible to have high clustering of peers and still deliver a clear stream to all of them, as long as a few random connections are allowed to be created when close neighbors can’t provide a suffi cient download rate. Comparing the use of biased neighbor selection to random selection, traffic between ISPs is efficiently reduced in the overall system, the portion of traffic exchanged between peers in the same ISP experience a ten times increase or more in most scenarios, and in larger ISPs that contain many peers, 75% of all traffic is exchanged between peers within the ISP. Thus the design presented in this thesis can be recommended to developers and content providers that are looking to increase ISP friendliness in their existing or future peer-to-peer applications.De många möjligheter som Internet medför har gett upphov till ett stort antal Internet-baserade tjänster de senaste decennierna. Flertalet tjänster som tidigare endast fanns tillgängliga via andra kommunikationskanaler är numera också möjliga att nå via Internet. I och med att informationen som skall skickas via olika tjänster ökar så ökar också kraven på bandbredd, och för att kunna leverera video krävs en ansenlig bandbredd. Bandbredden som krävs av den som levererar videon ökar dessutom snabbt i takt med antalet mottagare av den. För att kunna skapa Internet-baserade tjänster för video som tillåter ett större antal användare har forskare och företag börjat använda peer- to-peer-baserade lösningar, där användarna av tjänsten samarbetar och bidrar med deras egen bandbredd för att göra det möjligt för samtliga användare att ta emot videon. Detta arbete beskriver hur ett peer-to-peer-system för live-video kan utformas, och tillhandahåller resultat från simulationer med en implementation av systemet. Det huvudsakliga målet med systemets design är att minska bördan som peer-to-peer-system vanligen utgör för internetleverantörer. Denna typ av system genererar ofta stora mängder data, som i de flesta fall skickas mellan användare som befinner sig i nätverk tillhörande olika internetleverantörer, trots att samma data ofta finns tillgänglig på närmare håll – det vill säga hos användare som tillhör samma internetleverantör som mottagaren. Detta är ett problem för internetleverantörerna eftersom de ofta behöver betala för trafik som lämnar eller går till deras nätverk. Utöver detta så kan de anslutningar som existerar mellan dessa nätverk inte alltid klara sådana mängder trafik, vilket gör att alla användare av de anslutningarna blir lidande. Detta har lett till att vissa internetleverantörer begränsar eller inte tillåter peer-to-peer-trafik överhuvudtaget. Systemet som utformats i detta arbete bygger på gossiping (ryktesspridning) för att förse användare med videoströmmen. För att minimera mängden trafik som skickas mellan användare hos olika internetleverantörer så jämför användarna avståndet i nätverkstopologin till andra användare och skapar bara anslutningar till de som befinner sig närmast. Avståndet mellan två internetleverantörer utgörs av antalet anslutningar mellan två internetleverantörers nätverk som måste passeras på vägen. Dessa avstånd är lagrade i en databas som finns lokalt hos varje användare. Så länge en användare kan se en videoström utan störningar så laddas den endast ner från närbelägna användare, men skulle dessa inte kunna tillgodose användaren med tillräcklig datahastighet så kommer andra, slumpmässigt utvalda, också att kontaktas för att bidra med delar av videoströmmen till denna användare. I den utvärdering av systemet som gjorts så har det visat sig fungera väl när tillgängliga resurser som bandbredd och tillförlitligheten i det fysiska nätverket är begränsade, samt under svåra förhållanden som när en stor del av användarna lämnar systemet samtidigt. Utvärderingen visar också att användarupplevelsen inte påverkas av förändringen som det innebär att föredra kommunikation med närbelägna användare, så länge några få slumpmässiga anslutningar är tillåtna i de fall då användare i närheten inte kan tillhandahålla tillräcklig datahastighet. Jämfört med att välja alla kommunikationspartners slumpmässigt så minskar tillvägagångssättet i detta arbete effektivt trafiken mellan olika internetleverantörer både sett till hela systemet och i enskilda nätverk—andelen trafik som utbyts mellan användare tillhörande samma internetleverantör blir i de flesta fall tio gånger större—och i stora nätverk som innehåller många användare så utgör trafik mellan dess användare 75 % av all systemets trafik i detta nätverk. Den design som utformats i detta arbete kan därför rekommenderas till utvecklare och tillhandahållare av både existerande och framtida tjänster som använder peer-to-peer-teknik, och som är intresserade av att minska belastningen som deras system utgör för internetleverantörer.
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Bachmann, Fabienne. "Soll ich - Soll ich nicht? : eine qualitative Studie zum Thema Führungsdilemmata und Persönlichkeit /." Zürich, 2004. http://www.zhaw.ch/fileadmin/user_upload/psychologie/Downloads/Bibliothek/Arbeiten/D/d1792.pdf.
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Herzog, Madeleine. ""Ich bin... nicht ich" : Subjektivität, Gesellschaft und Geschlechterordnung in Gerlind Reinshagens dramatischem Werk /." Bielefeld : Aisthesis Verl, 1995. http://catalogue.bnf.fr/ark:/12148/cb375041682.
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Tüpker, Rosemarie. "Ich singe was ich nicht sagen kann zu einer morphologischen Grundlegung der Musiktherapie /." Regensburg : G. Bosse, 1988. http://books.google.com/books?id=UPo2AAAAMAAJ.
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Ekstener, Albin, and Kristoffer Andersson. "Återanvändning av ett företags åtgärder inom ISO 9001:2015 & ISO 14001:2015." Thesis, Jönköping University, Tekniska Högskolan, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-54037.
Full textAbstract:
There are a variety of advantages to companies certifying their management system according to the ISO standards that exist. Examples of these advantages are that you get a tool that helps to conduct your business in a better way as you often get into continuous improvements in this context. This report concerns two companies, Götessons Industri AB and company X, company X was acquired just over a year ago by the Götessons Group. The Götessons Group wants all companies in the Group to be certified according to both ISO 9001:2015 and ISO 14001:2015. The purpose of the work was therefore to develop appropriate solutions to be able to certify a management system at company X in accordance with ISO requirements. This should be done by trying to take as much from the solutions that Götessons used to obtain a certificate and then apply this to company X. The work also briefly addresses why companies choose to be certified according to ISO standards, but also a description of what a functioning management system can look like. The theories used to create a foundation in the work are ISO 9001:2015, ISO 14001:2015, Management System and Management System Standard. To supplement these theories, a number of different methods have also been used in the form of document studies, literature studies, investigations, and interviews. The document study that has been carried out is to review Götesson's management system. The literature study that has been done is primarily an in-depth study at SIS on what a certification means. The investigations and interviews carried out are visits to the various companies and related interviews. The interviews have been with staff but mainly with the company's external auditor who has over 20 years of experience in certifications. The work resulted in the reuse of a large part of Götesson's management system to company X’s management system. Some parts can be transferred without further adaptation, while some parts require a greater adaptation to better suit the business. When introducing a management system within a corporate group, the strategy used in the study lead to both time savings and cost savings for the companies involved. The work also showed that in this case it will not be possible to apply all the measures as the activities differ in certain processes.