Dissertations / Theses on the topic 'ISCS'
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Nuth, Manunya. "Mechanism of Fe-S cluster biosynthesis the [2Fe-2S] IscU as a model scaffold /." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1092856116.
Full textDocument formatted into pages. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Aug. 18.
Tantalean, Vásquez Juan Carlos. "La cisteina desulfurasa (IscS) de Geobacillus stearothermophilus V confiere a Escherichia Cole resistencia a la telurito de potasio." Tesis, Universidad de Chile, 2003. http://www.repositorio.uchile.cl/handle/2250/106710.
Full textBricault, Laurent. "Isis myrionyme." Paris 4, 1994. http://www.theses.fr/1994PA040152.
Full textThe cult of the egyptian goddess isis went to europe since the beginning of the ivth century bc. Greeks and latins developped a rich vocabulary to qualify the powers and attributes of the goddess, inspired by both hellenic and egyptian traditions. A text from the beginning of the irst century ad, known as p. Oxy. Xi 1980, published in 1915, is long isis litany, written in greek but inspired by the egyptian hymns from philae and assuan. This text could be divided in three parts; first, a long geographical list of the isis cult centers, second an invocatio n to the goddess and third a long hymn. 298 lines long, in twelve comumns, it's unfortunately incomplete at the beginning, and, probably, at the end too
Przybyla-Toscano, Jonathan. "Étude des protéines NFU, ISCA et FDX, impliquées dans la maturation des centres fer-soufre dans les mitochondries d’Arabidopsis thaliana." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0127.
Full textIn plants, iron-sulfur (Fe-S) proteins are involved in crucial processes such as photosynthesis and respiration. The maturation of these proteins requires the de novo synthesis of their Fe-S clusters through dedicated assembly machineries. Plants have three Fe-S cluster assembly machineries, namely SUF, ISC and CIA, devoted to the maturation of plastidial, mitochondrial and nuclear or cytosolic proteins, respectively. During the mitochondrial Fe-S protein maturation, a [2Fe-2S] cluster is first assembled on the ISU scaffold protein then transferred to target proteins with the help of chaperones and various transfer proteins. If these steps are sufficient for the maturation of [2Fe-2S] proteins, a reductive coupling process of two [2Fe-2S] clusters is required for the maturation of [4Fe-4S] proteins. This conversion needs transfer proteins and an electrons donor, potentially the same ferredoxin which acts during the first step of the Fe-S cluster biogenesis for sulfur reduction. By combining molecular, biochemical and genetic approaches, the involvement of NFU and ISCA transfer protein and mitochondrial ferredoxin (mFDX) in the late transfer and conversion steps has been explored during this PhD project by using the Arabidopsis thaliana plant model. Yeast complementation experiments have demonstrated that plant NFU and ISCA proteins have functions similar to their respective orthologs, suggesting that these late steps are conserved. However, unlike yeast, the characterization of nfu mutant lines indicates that both proteins are essential for early embryonic development. At the molecular level, in vivo and in vitro approaches have shown an interaction between ISCA1a or ISCA1b and ISCA2, NFU4 and NFU5 but no interaction with the two mFDX whose participation in the late steps remains uncertain. The formation of ISCA1-ISCA2 holo-heterocomplexes has been confirmed by co-expression in E. coli and purification of recombinant proteins. Overall, the literature and results obtained here highlight a model where ISCA1/2 heterocomplexes would act immediately downstream of NFU proteins which would a minima allow [4Fe-4S] cluster maturation of the lipoate synthase. This sole partner could primarily explain the lethality of a nfu4 x nfu5 double mutant because the activity of several proteins central for the mitochondrial metabolism depends on lipoic acid
Hadra, Dana. "ISIS: Past, Present and Future?: Pro-ISIS Media and State Formation." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104188.
Full textThis paper examines the role that media plays in the state building strategy of the Islamic State of Iraq and al-Sham (ISIS). Research findings suggest that ISIS is not merely a disorderly group of militants, but is a sophisticated organization driven by powerful religious and political ideas. The goal of my research is to tap into the intellectual face of ISIS, to uncover ISIS's own arguments and state building aspirations. In order to gain a more comprehensive understanding of ISIS, this paper examines how ISIS spreads its message and analyzes the significance of that message as it relates to state formation
Thesis (BA) — Boston College, 2015
Submitted to: Boston College. College of Arts and Sciences
Discipline: Arts and Sciences Honors Program
Discipline: Islamic Civilization and Societies
Kumar, Nadella Navin. "Evaluation of ISDS software." Master's thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-01262010-020122/.
Full textKameníček, Lukáš. "Návrh systém managementu ISMS." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229425.
Full textPospíchal, Jindřich. "Zavedení ISMS v podniku." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-241309.
Full textHavlík, Michal. "Návrh průmyslového řešení ISMS." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2017. http://www.nusl.cz/ntk/nusl-318610.
Full textPawlik, Jan. "Zavedení ISMS v podniku." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2015. http://www.nusl.cz/ntk/nusl-224837.
Full textCull, Dominic. "ISPs IN THE MIDDLE." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/4595.
Full textŘehořek, Tomáš. "Dopady ISDS na uživatele." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-198252.
Full textAsp, Sandin Agnes. "A simplified ISMS : Investigating how an ISMS for a smaller organization can be implemented." Thesis, Högskolan i Skövde, Institutionen för informationsteknologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20238.
Full textTawaifi, Alexandra. "ICC and ISIS : An Examination of the Rome Statute Regarding Individuals Operating under ISIS." Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-61207.
Full textUlfskans, Niklas, and Christian Thorell. "ISPS : Vakten i Göteborgs oljehamn." Thesis, University of Kalmar, Kalmar Maritime Academy, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-241.
Full textMed anledning av ISPS- kodens inträdande 2004 och personliga erfarenheter från fartyg och skyddsvaktsarbete har vi valt att fördjupa oss i ämnet portvaktens arbetsuppgifter. Vad vi har observerat sedan tidigare är att den allmänna uppfattningen bland ombordanställda är att portvakten är i vägen och det tar lång tid att komma till sin arbetsplats på fartyget.
Detta är en deskriptiv uppsats, där vi gjort en kvalitativ studie som bygger på intervju med vaktpersonal. Intervjun är sedan jämförd med de regler som finns för vakten i porten. Vi har avgränsat oss till att undersöka Göteborgs hamn, då denna var först i Europa att införa ISPS. Vi har intervjuat Magnus Rosenqvist, gruppchef på G4S i Göteborgs hamn. Detta har vi sedan jämfört med vad sjöbefälsstudenter på Högskolan i Kalmar har för erfarenheter och uppfattningar.
Vakten ansvarar för tillträdet till hamnområdet. Anledningen varför kontrollerna är så höga är för att upprätthålla hamnskyddet, inte fartygsskyddet. Vakten har samma ISPS- utbildning som resterande hamnpersonal, den utbildning en väktare måste inneha, men i Göteborgs hamn måste man dessutom vara skyddsvakt.
In connection with the ISPS- code's arising in 2004 and personal experiences from ships and security guarding, we have selected to deepen ourselves in the matter the gatekeeper’s duties. We have observed already that the general view among the vessel’s apployes, that the gatekeeper is in the way and it takes a long time to get to the workplace onboard the ship.
This is a descriptive essay, where we have done a qualitative study that builds on interview with local security personnel. The interview is then compared with the rules that are for the security guard in the gate. We have delimited ourselves to examining Gothenburg's port, because this is the first port in Europe to introduce the ISPS- code. We have interviewed Magnus Rosenqvist, squad commander at G4S in Gothenburg’s port. This result is then compared with the experiences and thoughts of students at Kalmar Maritime Academy.
The security guards are responsible for the access to the port area. The reason why the controls are so high is in order to maintain the port’s protection, not the ship’s protection. The security guard has the same ISPS education that all port personnel have, the education a general security guard must hold, but in Gothenburg’s port a security guard also must have a “skyddsvakt’s” education.
Fine, Zoe D. "Becoming a Woman of ISIS." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7619.
Full textDejmek, Martin. "Zavedení ISMS v obchodní společnosti." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2013. http://www.nusl.cz/ntk/nusl-224221.
Full textPalarczyk, Vít. "Zavedení ISMS v malém podniku." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2015. http://www.nusl.cz/ntk/nusl-224894.
Full textTrunkát, Jan. "Návrh zavedení ISMS ve firmě." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2015. http://www.nusl.cz/ntk/nusl-225000.
Full textSvoboda, Milan. "Zavedení ISMS v malém podniku." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-241114.
Full textKuchařík, Lukáš. "Návrh ISMS v průmyslovém prostředí." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-241472.
Full textDokoupil, Ondřej. "Návrh metodiky pro zavedení ISMS." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-254270.
Full textHensl, Marek. "Zavedení ISMS pro základní školu." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2017. http://www.nusl.cz/ntk/nusl-318615.
Full textLopes, Bruno Cardoso 1985. "Design and evaluation of compact ISAs." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/275494.
Full textTese (doutorado) - Universidade Estadual de Campinas, Instituto de Computação
Made available in DSpace on 2018-08-24T12:29:38Z (GMT). No. of bitstreams: 1 Lopes_BrunoCardoso_D.pdf: 3162388 bytes, checksum: 3a46d0fb9404a69bf87489922e4743b0 (MD5) Previous issue date: 2014
Resumo: Sistemas embarcados modernos são compostos de SoC heterogêneos, variando entre processadores de baixo e alto custo. Apesar de processadores RISC serem o padrão para estes dispositivos, a situação mudou recentemente: fabricantes estão construindo sistemas embarcados utilizando processadores RISC - ARM e MIPS - e CISC (x86). A adição de novas funcionalidades em software embarcados requer maior utilização da memória, um recurso caro e escasso em SoCs. Assim, o tamanho de código executável é crítico, porque afeta diretamente o número de misses na cache de instruções. Processadores CISC costumavam possuir maior densidade de código do que processadores RISC, uma vez que a codificação de instruções com tamanho variável beneficia as instruções mais usadas, os programas são menores. No entanto, com a adição de novas extensões e instruções mais longas, a densidade do CISC em aplicativos recentes tornou-se similar ao RISC. Nesta tese de doutorado, investigamos a compressibilidade de processadores RISC e CISC; SPARC e x86. Nós propomos uma extensão de 16-bits para o processador SPARC, o SPARC16. Apresentamos também, a primeira metodologia para gerar ISAs de 16-bits e avaliamos a compressão atingida em comparação com outras extensões de 16-bits. Programas do SPARC16 podem atingir taxas de compressão melhores do que outros ISAs, atingindo taxas de até 67%. O SPARC16 também reduz taxas de cache miss em até 9%, podendo usar caches menores do que processadores SPARC mas atingindo o mesmo desempenho; a redução pode chegar à um fator de 16. Estudamos também como novas extensões constantemente introduzem novas funcionalidades para o x86, levando ao inchaço do ISA - com o total de 1300 instruções em 2013. Alem disso, 57 instruções se tornam inutilizadas entre 1995 e 2012. Resolvemos este problema propondo um mecanismo de reciclagem de opcodes utilizando emulação de instruções legadas, sem quebrar compatibilidade com softwares antigos. Incluímos um estudo de caso onde instruções x86 da extensão AVX são recodificadas usando codificações menores, oriundas de instruções inutilizadas, atingindo até 14% de redução no tamanho de código e 53% de diminuição do número de cache misses. Os resultados finais mostram que usando nossa técnica, até 40% das instruções do x86 podem ser removidas com menos de 5% de perda de desempenho
Abstract: Modern embedded devices are composed of heterogeneous SoC systems ranging from low to high-end processor chips. Although RISC has been the traditional processor for these devices, the situation changed recently; manufacturers are building embedded systems using both RISC - ARM and MIPS - and CISC processors (x86). New functionalities in embedded software require more memory space, an expensive and rare resource in SoCs. Hence, executable code size is critical since performance is directly affected by instruction cache misses. CISC processors used to have a higher code density than RISC since variable length encoding benefits most used instructions, yielding smaller programs. However, with the addition of new extensions and longer instructions, CISC density in recent applications became similar to RISC. In this thesis, we investigate compressibility of RISC and CISC processors, namely SPARC and x86. We propose a 16-bit extension to the SPARC processor, the SPARC16. Additionally, we provide the first methodology for generating 16-bit ISAs and evaluate compression among different 16-bit extensions. SPARC16 programs can achieve better compression ratios than other ISAs, attaining results as low as 67%. SPARC16 also reduces cache miss rates up to 9%, requiring smaller caches than SPARC processors to achieve the same performance; a cache size reduction that can reach a factor of 16. Furthermore, we study how new extensions are constantly introducing new functionalities to x86, leading to the ISA bloat at the cost a complex microprocessor front-end design, area and energy consumption - the x86 ISA reached over 1300 different instructions in 2013. Moreover, analyzed x86 code from 5 Windows versions and 7 Linux distributions in the range from 1995 to 2012 shows that up to 57 instructions get unused with time. To solve this problem, we propose a mechanism to recycle instruction opcodes through legacy instruction emulation without breaking backward software compatibility. We present a case study of the AVX x86 SIMD instructions with shorter instruction encodings from other unused instructions to yield up to 14% code size reduction and 53% instruction cache miss reduction in SPEC CPU2006 floating-point programs. Finally, our results show that up to 40% of the x86 instructions can be removed with less than 5% of overhead through our technique without breaking any legacy code
Doutorado
Ciência da Computação
Doutor em Ciência da Computação
Štukhejl, Kamil. "Návrh zavedení ISMS ve veřejné správě." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2019. http://www.nusl.cz/ntk/nusl-399673.
Full textLukošienė, Kristina. "Eseistinis mąstymas Cz. Miłosz‘o romane "Isos slėnis"." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20080804_110757-73347.
Full textAnalysis of the essayistic thinking in the novel by Miłosz The Issa Valley helps to understand new situation in modern day culture. In this Master’s paper, we analyze similarities and differences between autobiographical novel and essay. The goal of this Master’s paper is to overlook theories of autobiography and essay genres, to name the differences and similarities of Miłosz‘s novel The Issa Valley and native essay texts, such like Native Realm (Gimtoji Europa), In search of a Homeland (Tėvynės ieškojimas) and Roadside dog (Pakelės šunytis). The base of an essay is very important. There is no rules to tell, what is a pure essayistic text (sometimes called perfect essay), and what is not. Essayistic and essayistic thinking are not identical concepts. The essayistic thinking is identifiable by value judgment, when the process of thinking is most important. It is connected with special quality of thinking. The autobiographical novel is based on the author’s true story of his life. The writer uses fictional details and turns his life to fiction. Names and locations are usually changed, but and actions are more dramatic, but the author stays recognizable. The Master’s paper consists of three parts. In the first part we give a brief overview of autobiography and essay theory and development. The second and the third parts are the survey of the novel The Issa Valley. In this novel we find essayistic thinking. According to that survey, we draw a conclusion, that Miłosz‘s novel... [to full text]
Cheema, Ansar Zaman, and Imran Ullah Saqib. "Collaborating ISPs Supporting Various Real-Time Services." Thesis, Halmstad University, School of Information Science, Computer and Electrical Engineering (IDE), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-4902.
Full textThese days, internet service providers (ISPs) face the challenge about how to increase profitability while hey must ensure a good quality service at the same time and scale up their network. The study involves previous research papers. On the bases of those papers,the comparison is made between different alternatives. The purpose on this study is to find a solution that combines different methods and configurations about how several ISPs could cooperate. Its implementation includes how different ISPs can configure their networks to cooperate on service provision supporting various real-time services.
Duggan, Carl. "Isis : a study in Lully's French style." Thesis, Durham University, 1985. http://etheses.dur.ac.uk/7572/.
Full textTham, Sebastian. "Ledningsstrukturer inom terroristorganisationer - En fallstudie om ISIS." Thesis, Försvarshögskolan, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-5482.
Full textTotti, Maria. "Ausgewählte Texte der Isis- und Sarapis - Religion /." Hildesheim : G. Olms, 1985. http://catalogue.bnf.fr/ark:/12148/cb37592223r.
Full textTakács, Sarolta A. "Isis and Sarapis in the roman world /." Leiden : E. J. Brill, 1995. http://catalogue.bnf.fr/ark:/12148/cb357223360.
Full textŠebrle, Petr. "Zavedení ISMS do podniku podporujícího kritickou infrastrukturu." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2017. http://www.nusl.cz/ntk/nusl-318630.
Full textAjisafe, Dickson O. A. "Radicalisation of European Citizens and ISIS Terrorism." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/63963.
Full textMini Dissertation (MA)--University of Pretoria, 2017.
Modern European Languages
MA
Unrestricted
Colin, Florent. "Caractérisation du rôle de la frataxine dans la machinerie de biosynthèse des clusters FeS et développement d'un logiciel de prédiction des protéines FeS." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ113/document.
Full textFriedreich Ataxia (FA) is the most prevalent form of autosomal recessive ataxia in the Caucasian population. Frataxin is implicated in the biosynthesis of iron-sulfur (FeS). The first axis of my work was to better characterize the function of Frataxin in the “early” complex of FeS clusters biosynthesis (NFS1/ISD11/ISCU). I was able to show the crucial involvement of Frataxin in the control of iron entry in this complex, on the enzymatic activity of NFS1 and on the transfert of FeS cluster to apo-proteins. Thesecond axis was the development of a bio-informatic software (PredISC) that is able to predict potential iron-sulfur containing proteins. The software allows us to generate a list of candidates that will be compiled in a database. In the future transversal approaches have to be associated in order to reduced the number of candidates, and increase their interest
Ramaswamy, Padmanabhan. "Provisioning task based symmetric QoS in iSCSI SAN." Thesis, Wichita State University, 2008. http://hdl.handle.net/10057/2096.
Full textWichita State University, College of Engineering, Dept. of Electrical and Computer Science Engineering
Includes bibliographic references (leaves 60-65)
Koscielniak, S. R. "Longitudinal beam dynamics studies on the ISIS synchrotron." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379845.
Full textRamaswamy, Padmanabhan Pendse Ravi. "Provisioning task based symmetric QoS in iSCSI SAN." A link to full text of this thesis in SOAR, 2008. http://hdl.handle.net/10057/2096.
Full textCopyright 2008 by Padmanabhan Ramaswamy. All Rights Reserved. Includes bibliographical references (leaves 60-65).
Felldén, Daniel. "Det moderna kalifatets strategi – en fallstudie om ISIS." Thesis, Försvarshögskolan, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-8641.
Full textClancy, Timothy. "The Dynamics of ISIS: An Emerging-State Actor." Digital WPI, 2016. https://digitalcommons.wpi.edu/etd-theses/206.
Full textSpiquel, Agnès. "La déesse cachée : Isis dans l'oeuvre de Hugo." Paris 7, 1989. http://www.theses.fr/1989PA070065.
Full textThe isiac myth, in its commonly accepted figures in hugo's times, is for him the source of manifold and contradictory questionings throughout his work. Negatively, he gathers under the image of lilithisis, emanation-daughter of satan in la fin de satan, all that he feels obscure and "fatal" in the east, egypt and isis among other heathen goddesses. Lilithisis, a condensation of shadow, stands as a figure of the absolute evil, which numerous patterns echo in his novels. Besides, the veiled isis is nature : the nature which the scientific endeavour of mankind attempts to unveil. But the promise of light is matched with an acceptation of shadow : which also involves the contemplation of the veil, becoming then transparent. Isis is thus a star radiating from behind the veil : the radiance stands metaphorically for the notion of immanence which points to the type of presence of the other in the same, the infinite in the finite. Lastly, isis is one of the myths through which hugo views woman : the salvation is not brought about by her sheer function in relation to man but by her mere presence and, still more, by the specific union of flesh and soul she essentially accomplishes and which again belongs to the sphere of immanence. A myth of the presence-absence of alterity, isis become a figure of the soul. . . .
Ferreira, Sónia Cristina das Neves. "ISCR and their association with antibiotic resistance genes." Doctoral thesis, Universidade de Aveiro, 2010. http://hdl.handle.net/10773/974.
Full textA prevalência de bactérias resistentes a antibióticos em ambiente hospitalar tem vindo a tornar-se dramática e preocupante a nível mundial. Contudo, com a utilização inadequada de antibióticos em áreas tão diversas como a veterinária, a aquacultura e a agricultura, esta deixou de estar confinada ao ambiente hospitalar, sendo o ambiente um reservatório natural de microganismos resistentes a estes compostos. O conhecimento detalhado dos determinantes de resistência a antibióticos presentes nestes ambientes, sejam estes genes de resistência ou estruturas envolvidas na sua mobilização, é fundamental, não só do ponto de vista do conhecimento como para a eventual implementação de medidas de contenção da sua disseminação. Neste contexto, são necessários estudos que permitam conhecer o panorama mais realista da distribuição destes determinantes de resistência a antibióticos, quer no meio ambiente quer no ambiente clínico. Assim, constituiu objectivo principal deste trabalho contribuir para o conhecimento do panorama actual da prevalência e distribuição dos elementos ISCR, bem como de outros determinantes de resistência a antibióticos em espécies de Gram-negativo clinicamente relevantes (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii e Citrobacter freundii) recolhidas a partir de amostras de pacientes do Hospital Infante D. Pedro, EPE, Aveiro, Portugal, entre 2006 e 2008. Adicionalmente, foram também recolhidas bactérias de Gram-negativo do meio ambiente, a partir de amostras de águas e de vísceras de peixes, nas quais foram igualmente pesquisados os elementos acima referidos. À excepção dos isolados de E. coli e de Gramnegativo ambientais, todas as estirpes estudadas foram seleccionadas com base no seu perfil de multirresistência a antibióticos. Os resultados mostraram que em todas as espécies recolhidas no ambiente hospitalar foi detectada a presença de elementos ISCR, do tipo ISCR1 ou ISCR2. O elemento ISCR1, foi encontrado em isolados de E. coli, K. pneumoniae e C. freundii e o elemento ISCR2 em isolados de A. baumannii. Não foi detectada a presença de ISCRs nos isolados de Gram-negativo ambientais, o que sugere que a ocorrência dos mesmos é fortemente influenciada pela pressão selectiva exercida pelo ambiente em que os microrganismos se encontram. Genes qnr e integrões de classe 1 foram os determinantes de resistência mais frequentemente encontrados associados aos elementos ISCR1. Os vários determinantes de resistência foram encontrados em diferentes contextos genéticos e localizados em estruturas móveis, nomeadamente em plasmídeos. O elemento ISCR2 presente em isolados de A. baumannii encontra-se associado ao gene sul2 em todos os isolados, dentro de um mesmo contexto genético e com uma localização cromossomal. Contudo, o contexto genético encontrado nestes isolados é novo não tendo sido descrito até à data em outros microrganismos. O presente estudo constitui a primeira descrição de elementos ISCR intrinsecamente ligados a genes de resistência a antibióticos, em Portugal. Uma vez que estes elementos parecem ser responsáveis pela mobilização de um grande número de genes de resistência a antibióticos, a sua elevada incidência entre estirpes resistentes e multirresistentes, bem como a sua associação com genes de resistência é preocupante e requer vigilância.
Within the hospital environment, antibiotic resistant bacteria are a problem of concern worldwide. However, the antibiotic resistance has breached outside the confined hospital environment due to an inappropriate and intensive use of antibiotics in areas such as veterinary, aquaculture and agriculture, being the natural environment also a reservoir of antibiotic resistant microorganisms. Accurate and detailed studies focusing on the existing resistance determinants, either resistance genes or structures enhancing/involved in their dissemination, is needed in order to provide a realistic scenario of their distribution as well as for the implementation of measures that could prevent the dissemination of those genes. Thus, studies giving a wider and realistic panorama of the distribution of antibiotic resistance genes in both the natural and the hospital environment are of utmost importance. The main goal of this thesis was to contribute to the present knowledge of distribution and prevalence of antibiotic resistance genes and ISCRs elements in clinically relevant Gram-negative species (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Citrobacter freundii) collected from clinical specimens from patients in the Hospital Infante D. Pedro, EPE, Aveiro, Portugal between 2006 and 2008. Additionally, environmental Gram-negative isolates, collected from water and fish guts were also screened for the presence of the ISCR elements. All the isolates that were included in the present study were multi-drug resistant, with the exception of Escherichia coli and the Gram-negative environmental isolates. The results obtained revealed that the ISCR1 and ISCR2 elements were present in all the species collected within the hospital settings. ISCR1 was present in E. coli, K. pneumoniae and C. freundii isolates and ISCR2 was detected in the A. baumannii isolates. The presence of ISCRs was not detected among the environmental Gram-negative isolates, suggesting that the occurrence of ISCR is clearly biased by the pressure exerted by the environment from where the microorganisms were isolated. qnr genes and class 1 integrons were the main resistance determinants found associated with ISCR1 and were both described in different genetic contexts, located on mobile structures such as plasmids. Moreover, the ISCR2 element was found associated with the sul2 gene in all the A. baumannii isolates with the same genetic context and located on the chromosome. Noteworthy is that the genetic context described is unique and was never described before in other microorganisms. This is the first study reporting the presence of ISCR elements in Portuguese isolates. Since these elements are responsible for the mobilization of several antibiotic resistance genes and were found intrinsically linked to them, their high incidence, among multi-drug resistant isolates is disconcerting and requires surveillance.
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Full textKohoutek, Josef. "Zavádění bezpečnostních opatření dle ISMS do malé společnosti." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-241610.
Full textKlepárník, Roman. "Návrh zavedení nutných oblastí ISMS ve veřejné správě." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2018. http://www.nusl.cz/ntk/nusl-378365.
Full textFoltýn, Adam. "Akvizice služby pro zabezpečení emailové komunikace dle ISMS." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2018. http://www.nusl.cz/ntk/nusl-378381.
Full textPexa, Marek. "Zavedení bezpečnostních opatření dle ISMS pro základní školu." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2019. http://www.nusl.cz/ntk/nusl-402084.
Full textArun, Asim Kumar. "ISIS threat to India : how should India respond?" Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/60305.
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Niu, Yue, Ning Hao, and Lingling An. "Detection of rare functional variants using group ISIS." BioMed Central, 2011. http://hdl.handle.net/10150/610089.
Full textMeyer, Kyrill, and Michael Thieme. "Theory and Practice for System Services Providers in Complex Value and Service Systems." Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-128474.
Full textŠupolová, Veronika. "Aktuální vývoj informačních systémů veřejné správy v ČR." Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-1547.
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