Relevant bibliographies by topics / Ischaemic stroke research

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters

Academic literature on the topic 'Ischaemic stroke research'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Ischaemic stroke research.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Ischaemic stroke research"

1

Chauhan, Anjali, Hope Moser, and Louise D. McCullough. "Sex differences in ischaemic stroke: potential cellular mechanisms." Clinical Science 131, no. 7 (March 17, 2017): 533–52. http://dx.doi.org/10.1042/cs20160841.

Full text
Abstract:
Stroke remains a leading cause of mortality and disability worldwide. More women than men have strokes each year, in part because women live longer. Women have poorer functional outcomes, are more likely to need nursing home care and have higher rates of recurrent stroke compared with men. Despite continued advancements in primary prevention, innovative acute therapies and ongoing developments in neurorehabilitation, stroke incidence and mortality continue to increase due to the aging of the U.S. population. Sex chromosomes (XX compared with XY), sex hormones (oestrogen and androgen), epigenetic regulation and environmental factors all contribute to sex differences. Ischaemic sensitivity varies over the lifespan, with females having an “ischaemia resistant” phenotype that wanes after menopause, which has recently been modelled in the laboratory. Pharmacological therapies for acute ischaemic stroke are limited. The only pharmacological treatment for stroke approved by the Food and Drug Administration (FDA) is tissue plasminogen activator (tPA), which must be used within hours of stroke onset and has a number of contraindications. Pre-clinical studies have identified a number of potentially efficacious neuroprotective agents; however, nothing has been effectively translated into therapy in clinical practice. This may be due, in part, to the overwhelming use of young male rodents in pre-clinical research, as well as lack of sex-specific design and analysis in clinical trials. The review will summarize the current clinical evidence for sex differences in ischaemic stroke, and will discuss sex differences in the cellular mechanisms of acute ischaemic injury, highlighting cell death and immune/inflammatory pathways that may contribute to these clinical differences.
APA, Harvard, Vancouver, ISO, and other styles
2

Lake, Evelyn M. R., Paolo Bazzigaluppi, and Bojana Stefanovic. "Functional magnetic resonance imaging in chronic ischaemic stroke." Philosophical Transactions of the Royal Society B: Biological Sciences 371, no. 1705 (October 5, 2016): 20150353. http://dx.doi.org/10.1098/rstb.2015.0353.

Full text
Abstract:
Ischaemic stroke is the leading cause of adult disability worldwide. Effective rehabilitation is hindered by uncertainty surrounding the underlying mechanisms that govern long-term ischaemic injury progression. Despite its potential as a sensitive non-invasive in vivo marker of brain function that may aid in the development of new treatments, blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has found limited application in the clinical research on chronic stage stroke progression. Stroke affects each of the physiological parameters underlying the BOLD contrast, markedly complicating the interpretation of BOLD fMRI data. This review summarizes current progress on application of BOLD fMRI in the chronic stage of ischaemic injury progression and discusses means by which more information may be gained from such BOLD fMRI measurements. Concomitant measurements of vascular reactivity, neuronal activity and metabolism in preclinical models of stroke are reviewed along with illustrative examples of post-ischaemic evolution in neuronal, glial and vascular function. The realization of the BOLD fMRI potential to propel stroke research is predicated on the carefully designed preclinical research establishing an ischaemia-specific quantitative model of BOLD signal contrast to provide the framework for interpretation of fMRI findings in clinical populations. This article is part of the themed issue ‘Interpreting BOLD: a dialogue between cognitive and cellular neuroscience’.
APA, Harvard, Vancouver, ISO, and other styles
3

Moxon, Joseph V., Alexandra F. Trollope, Brittany Dewdney, Catherine de Hollander, Domenico R. Nastasi, Jane M. Maguire, and Jonathan Golledge. "The effect of angiopoietin-1 upregulation on the outcome of acute ischaemic stroke in rodent models: A meta-analysis." Journal of Cerebral Blood Flow & Metabolism 39, no. 12 (October 4, 2019): 2343–54. http://dx.doi.org/10.1177/0271678x19876876.

Full text
Abstract:
Clinical studies report that low circulating angiopoietin-1 concentration at presentation predicts worse outcomes after ischaemic stroke. Upregulating angiopoietin-1 may therefore have therapeutic benefit for ischaemic stroke. This systematic review assessed whether upregulating angiopoietin-1 improved outcomes in rodent models of ischaemic stroke. Random-effects models quantified the effect of angiopoietin-1 upregulation on stroke severity in terms of the size of cerebral infarction and the extent of blood–brain barrier permeability. Eleven studies utilising rat and mouse models of ischaemic stroke fulfilled the inclusion criteria. Meta-analyses demonstrated that angiopoietin-1 upregulation significantly reduced cerebral infarction size (standardised mean difference: –3.02; 95% confidence intervals: –4.41, –1.63; p < 0.001; n = 171 animals) and improved blood–brain barrier integrity (standardized mean difference: –2.02; 95% confidence intervals: –3.27, –0.77; p = 0.002; n = 129 animals). Subgroup analyses demonstrated that angiopoietin-1 upregulation improved outcomes in models of transient, not permanent cerebral ischaemia. Six studies assessed the effect of angiopoietin-1 upregulation on neurological function; however, inter-study heterogeneity prevented meta-analysis. In conclusion, published rodent data suggest that angiopoietin-1 upregulation improves outcome following temporary cerebral ischaemia by reducing cerebral infarction size and improving blood–brain barrier integrity. Additional research is required to examine the effect of angiopoietin-1 upregulation on neurological function during stroke recovery and investigate the benefit and risks in patients.
APA, Harvard, Vancouver, ISO, and other styles
4

Liu, Yan, Bo Yin, and Yanping Cong. "The Probability of Ischaemic Stroke Prediction with a Multi-Neural-Network Model." Sensors 20, no. 17 (September 3, 2020): 4995. http://dx.doi.org/10.3390/s20174995.

Full text
Abstract:
As is known, cerebral stroke has become one of the main diseases endangering people’s health; ischaemic strokes accounts for approximately 85% of cerebral strokes. According to research, early prediction and prevention can effectively reduce the incidence rate of the disease. However, it is difficult to predict the ischaemic stroke because the data related to the disease are multi-modal. To achieve high accuracy of prediction and combine the stroke risk predictors obtained by previous researchers, a method for predicting the probability of stroke occurrence based on a multi-model fusion convolutional neural network structure is proposed. In such a way, the accuracy of ischaemic stroke prediction is improved by processing multi-modal data through multiple end-to-end neural networks. In this method, the feature extraction of structured data (age, gender, history of hypertension, etc.) and streaming data (heart rate, blood pressure, etc.) based on a convolutional neural network is first realized. A neural network model for feature fusion is then constructed to realize the feature fusion of structured data and streaming data. Finally, a predictive model for predicting the probability of stroke is obtained by training. As shown in the experimental results, the accuracy of ischaemic stroke prediction reached 98.53%. Such a high prediction accuracy will be helpful for preventing the occurrence of stroke.
APA, Harvard, Vancouver, ISO, and other styles
5

Fraser, Justin F. "Standardisation of research strategies in acute ischaemic stroke." Lancet Neurology 15, no. 8 (July 2016): 784–85. http://dx.doi.org/10.1016/s1474-4422(16)30080-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Appleton, Jason P., Randeep Mullhi, and Naginder Singh. "Initial management of acute ischaemic stroke." British Journal of Hospital Medicine 82, no. 1 (January 2, 2021): 1–9. http://dx.doi.org/10.12968/hmed.2020.0193.

Full text
Abstract:
The management of acute ischaemic stroke has been revolutionised by effective reperfusion therapies including thrombolysis and mechanical thrombectomy. In particular, mechanical thrombectomy has heralded a new era in stroke medicine. There have also been developments to improve clinical outcomes for patients who have had an acute ischaemic stroke but are not eligible for this procedure. This article presents an update on the initial management of acute ischaemic stroke, including reperfusion therapies, periprocedural considerations and ongoing research for potential improvements in the care of these patients.
APA, Harvard, Vancouver, ISO, and other styles
7

Jia, Jia, Jie Li, and Jian Cheng. "H2S-based therapies for ischaemic stroke: opportunities and challenges." Stroke and Vascular Neurology 4, no. 2 (June 2019): 63–66. http://dx.doi.org/10.1136/svn-2018-000194.

Full text
Abstract:
Stroke is a cerebrovascular disease displaying high mortality and morbidity. Despite extensive efforts, only very few therapies are available for stroke patients as yet. Hydrogen sulfide (H2S) is thought to be a signalling molecule that is endogenously produced and plays functional roles in the central nervous system. Currently, numerous studies show that H2S impacts stroke outcomes in animal and cellular models. Here, we review the recent research regarding the effects of endogenously produced H2S as well as exogenous H2S donors on stroke pathology, focusing on the potential of H2S-based therapies in treating ischaemic stroke. We also discuss the several issues that hinder the clinical translation of H2S-based therapies from the bench. Taken together, we think that H2S-based therapies are promising strategies for treating cerebral ischaemia if we successfully address these issues.
APA, Harvard, Vancouver, ISO, and other styles
8

Kirkham, Fenella, Guillaume Sébire, Maja Steinlin, and Ronald Sträter. "Arterial ischaemic stroke in children." Thrombosis and Haemostasis 92, no. 10 (2004): 697–706. http://dx.doi.org/10.1160/th04-04-0209.

Full text
Abstract:
SummaryConditions associated with arterial ischaemic stroke in children include a great variety of diseases and triggers such as congenital heart malformations, sickle cell disease, infections and vasculopathies, although up to 50% are cryptogenic. An abnormal vascular status can be demonstrated by vascular imaging in up to 80% of children with ischaemic stroke, and case control studies demonstrate an association between ischaemic stroke in children and hereditary prothrombotic risk factors and infections such as Varicella. Conventional risk factors such as hypertension and dyslipidaemia may also play a role, and most children have several potential triggers rather than one single cause. This review focuses on clinical presentations, imaging methods, stroke subtypes, underlying conditions including prothrombotic risk factors, outcome and recurrence. Although data from randomised controlled trials, on which clinical practice might be based, are sparse, therapeutic approaches and future research directions are discussed.
APA, Harvard, Vancouver, ISO, and other styles
9

Kermode-Scott, Barbara. "Research suggests thrombolysis is effective for acute ischaemic stroke." BMJ 330, no. 7501 (May 19, 2005): 1167.2. http://dx.doi.org/10.1136/bmj.330.7501.1167-a.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Kang, Eugene Yu-Chuan, Yun-Hsuan Lin, Nan-Kai Wang, Ling Yeung, Caesar Luo, Wei-Chi Wu, Chi-Chin Sun, Je-Ho Kang, Ming-Jui Hung, and Tien-Hsing Chen. "Aspirin use in central retinal arterial occlusion to prevent ischaemic stroke: a retrospective cohort study in Taiwan." BMJ Open 9, no. 2 (February 2019): e025455. http://dx.doi.org/10.1136/bmjopen-2018-025455.

Full text
Abstract:
ObjectiveTo understand the efficacy of aspirin use for preventing ischaemic stroke after central retinal artery occlusion (CRAO).DesignThe retrospective cohort study was conducted using the National Health Insurance Research Database from 1998 to 2013.SettingA population-based study.ParticipantsA total of 9437 participants with newly diagnosed CRAO were identified. Participants who had a previous stroke and/or retinal vascular occlusion, were aged <20 years and used aspirin 3 months before the event were excluded. There were 3778 eligible participants matched by propensity score, and they were divided into aspirin (n=434) and aspirin-naive (n=1736) groups after the matching.MethodsCox proportional hazard models and cumulative survival curves were used to assess ischaemic stroke in the study groups, along with log-rank tests to compare group differences.Main outcome measuresIncidence of ischaemic stroke in the aspirin and aspirin-naive groups 1 year after CRAO.ResultsOf the 3778 patients with newly diagnosed CRAO, 151 (4%) had a subsequent ischaemic stroke within 1 year. The risk was especially high during the first week of the CRAO. No difference between the aspirin and aspirin-naive groups was found in risk of ischaemic stroke, haemorrhagic stroke, gastrointestinal bleeding, major bleeding, acute coronary syndrome, retinal vein occlusion, new-onset glaucoma, undergoing panretinal photocoagulation or all-cause mortality. Risk factors for ischaemic stroke within 1 year of CRAO included male gender (p=0.031; HR=1.46) and age (p=0.032; HR=1.14).ConclusionsAspirin use after a CRAO showed no benefit on attenuating the risk of ischaemic stroke. The risk of ischaemic stroke was increased after CRAO especially during the first week. Male gender and age were risk factors for ischaemic stroke after CRAO.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Ischaemic stroke research"

1

Qizilbash, Nawab. "The epidemiology of transient ischaemic attacks." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253395.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Sibson, Nicola Ruth. "A magnetic resonance imaging study of experimental cerebral ischaemia." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360825.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Ischaemic stroke research"

1

Henzi, Bettina, and Maja Steinlin. Stroke in children. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198722366.003.0013.

Full text
Abstract:
Stroke in children is a rare, but terrifying disease and its lifelong sequelae weigh heavy on patients and families. It is also increasingly recognized as a socioeconomic burden, ongoing for many years after the acute manifestation. There is a significant delay in diagnosis of childhood stroke. This is caused by several factors: lack of awareness among the public and professionals, childhood-specific manifestations, numerous stroke mimics, and last but not least, limited access to emergency neuroimaging for children. Fast stroke recognition tools need adaption to the special needs in children. Childhood arterial ischaemic stroke differs in aetiology from adult stroke with cerebral vasculopathies being the leading cause and cardioembolic aetiology ranking second. However, treatment guidelines are largely based on adult guidelines and expert consensus. Future research has to put emphasis on understanding pathophysiology, defining specific treatment options, and providing evidence for treatment guidelines in paediatric stroke.
APA, Harvard, Vancouver, ISO, and other styles
2

Christine, Roffe. Stroke care: what is in the black box? Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199689644.003.0014.

Full text
Abstract:
Key points• Most improvements in stroke care to date have been driven by research.• Immediate access to advanced imaging allows fast decision making, is cost-effective, and improves outcome.• Hyperacute interventions for acute ischaemic and haemorrhagic stroke can prevent permanent brain damage and reduce disability.• Strokes and stroke complications do not just happen during working hours: 24/7 working is essential for effective stroke management.• High quality nursing care is essential and has been shown to have a major impact on survival.• Pneumonia is the most common post-stroke complication, and can be prevented by early swallow assessment.• Urinary catheters are associated with infections and should be avoided.• Foot pumps reduce thromboembolism and save lives.
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Ischaemic stroke research"

1

Amantea, Diana, Rosaria Greco, Cristina Tassorelli, and Giacinto Bagetta. "Polarization of Microglia/Macrophages in Brain Ischaemia: Relevance for Stroke Therapy." In Springer Series in Translational Stroke Research, 303–28. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45345-3_12.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Guyler, Paul. "Early management of acute ischaemic stroke." In Stroke in the Older Person, 121–40. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198747499.003.0009.

Full text
Abstract:
This chapter, ‘Early management of acute ischaemic stroke’, addresses all the basic issues of thrombolysis as it has evolved over the last three decades. More importantly the journey and controversy concerning thrombolysis in older people is discussed at length with excellent trial evidence from specialist research. A review of all-important thrombolysis trials is succinctly described. New national clinical guidelines are analysed. Endovascular mechanical thrombectomy, which is rapidly developing, is described in detail with a review of the latest trials too. The author also highlights the importance of establishing cerebral blood flow as quickly and as completely and safely as possible.
APA, Harvard, Vancouver, ISO, and other styles
3

Birns, Jonathan, and Ajay Bhalla. "Management of acute stroke within the stroke pathway and stroke clinics." In Oxford Textbook of Geriatric Medicine, 921–32. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198701590.003.0119.

Full text
Abstract:
There have been considerable advances in stroke research leading to translation of drug therapy for stroke into the clinical arena. Thrombolysis for ischaemic stroke is a key advance that significantly reduces disability. This has revolutionized the manner in which acute stroke is treated as a medical emergency. The use of advanced imaging techniques and adjuncts to thrombolysis could potentially improve selection of patients who may benefit from reperfusion therapy such as mechanical thrombectomy and allow treatment decisions to be based on individual brain pathophysiology, rather than arbitrary time windows. It is likely that reconfiguration of stroke services may be required to accommodate further delivery of hyperacute interventions for acute stroke.
APA, Harvard, Vancouver, ISO, and other styles
4

Birns, Jonathan, and Ajay Bhalla. "Management of acute stroke within the stroke pathway and stroke clinics." In Oxford Textbook of Geriatric Medicine, 921–32. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198701590.003.0119_update_001.

Full text
Abstract:
There have been considerable advances in stroke research leading to translation of drug therapy for stroke into the clinical arena. Thrombolysis for ischaemic stroke is a key advance that significantly reduces disability. This has revolutionized the manner in which acute stroke is treated as a medical emergency. The use of advanced imaging techniques and adjuncts to thrombolysis could potentially improve selection of patients who may benefit from reperfusion therapy such as mechanical thrombectomy and allow treatment decisions to be based on individual brain pathophysiology, rather than arbitrary time windows. It is likely that reconfiguration of stroke services may be required to accommodate further delivery of hyperacute interventions for acute stroke.
APA, Harvard, Vancouver, ISO, and other styles
5

Burton, Christopher R., and Caroline Smith. "Understanding Stroke." In Adult Nursing Practice. Oxford University Press, 2012. http://dx.doi.org/10.1093/oso/9780199697410.003.0023.

Full text
Abstract:
The aim of this chapter is to provide nurses with the knowledge to be able to assess, manage, and care for people with stroke in an evidence-based and person-centred way. The chapter will provide a comprehensive overview of the seven stages of stroke, exploring best practice to deliver care, as well as to prevent or minimize further ill-health. Nursing assessments and priorities are highlighted throughout, and the nursing management of the symptoms and common health problems associated with stroke can be found in Chapters 23, 24, and 27, respectively. Stroke is defined as the rapid onset of focal neurological deficit lasting more than 24 hours (in which the patient survives the initial event), with no apparent cause other than disruption of blood supply to the brain (World Health Organization, 1978). As well as being the third commonest cause of death only in middle- and high-income countries (WHO, 1978) (along with cancer and heart disease), stroke is the largest cause of adult physical disability in the world (Bath and Lees, 2000). However, owing to advances in research and evidence synthesis, stroke is now a preventable and treatable disease (National Collaborating Centre for Chronic Conditions (NCCC), 2008). Despite its relative small weight (approximately 2% of body weight), the brain requires 750 ml of bloodflow every minute, and consumes nearly 45% of arterial oxygen (Alexandrov, 2003). Bloodflow to the brain is assured through two circulatory systems (anterior and posterior), which are connected by the circle of Willis, and supplied by the internal carotid and vertebral arteries. Disruption of this bloodflow can be either in the form of a bleed (haemorrhagic stroke) or clot (ischaemic stroke), and the clinical presentation will vary depending on the location of the disruption in the brain. Ischaemic strokes are more common and account for almost 70% of all events (Wolfe et al., 2002). Whilst thorough clinical examination is essential, the only clear tool to identify the type of stroke is to perform a brain scan using either magnetic resonance imaging (MRI) or computed tomography (CT) technology. It is important to note that, often, when a CT brain scan is performed within the first few hours of an event, the scan may not show any significant tissue damage because the changes that occur may take several days to be clearly visible.
APA, Harvard, Vancouver, ISO, and other styles
6

Minhas, Jatinder S., Amit K. Mistri, and Thompson G. Robinson. "Secondary prevention and revascularization in the older person." In Stroke in the Older Person, 353–64. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198747499.003.0023.

Full text
Abstract:
‘Secondary prevention and revascularization in the older person’ examines the proven and contentious issues of secondary prevention strategies following stroke or transient ischaemic attack; however, the majority of large randomized clinical trials supporting individual interventions are in a younger population than real-life, older, stroke survivors. Various strategies for secondary prevention, lifestyle approaches, research trials of antithrombotic therapy and blood pressure reduction, lipid modification, atrial fibrillation, glycaemia, surgical interventions, and intracerebral haemorrhage are dealt with in detail. The older population has greater disability and dependency from stroke and other comorbidities, and the benefits and risks of secondary prevention therapy may therefore differ from their younger counterparts. While there is a need for further research on secondary prevention strategies in older populations, the current management involves incorporation of evidence-based approaches into a pragmatic individualized approach, with careful consideration of risks and benefits.
APA, Harvard, Vancouver, ISO, and other styles
7

Sørensen, Mette, and Thomas Münzel. "Epidemiology of traffic noise and cardiometabolic disease." In ESC CardioMed, edited by Thomas Münzel, 3105–7. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0751.

Full text
Abstract:
Epidemiological research into the health effects of transportation noise has during the last decades focused on investigating effects on the cardiovascular system. These studies have consistently shown that exposure to road traffic and aircraft noise is associated with elevated blood pressure, prevalent arterial hypertension, as well as a higher risk of ischaemic heart disease. Moreover, recent studies have found exposure to road traffic and aircraft noise to be associated with a higher risk for stroke, and possibly atrial fibrillation. Lastly, new studies point towards transportation noise as a risk factor for metabolic disease, showing an association with obesity and development of diabetes. This chapter examines the epidemiological studies within this research area, with a focus on describing the level of evidence for each outcome, the size of the associations, and research gaps.
APA, Harvard, Vancouver, ISO, and other styles
8

Massberg, Steffen, Julinda Mehilli, and Adnan Kastrati. "The role of bivalirudin in percutaneous coronary intervention." In Oxford Textbook of Interventional Cardiology, 440–56. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199569083.003.025.

Full text
Abstract:
Rapid progress has been made in interventional cardiology over the past years, and many patients with coronary artery disease, even those with complex lesions, are nowadays being treated with percutaneous coronary interventions (PCI). As a result, a major focus of current cardiovascular research is on reducing negative peri-procedural clinical events associated with PCI, particularly in high-risk patients. Among the most dangerous peri-procedural events are thrombotic complications, leading to recurrent myocardial or cerebral ischaemia, often with fatal outcome. Anticoagulant and antithrombotic treatment, therefore, is an integral part of current PCI strategies. It is needless to say that prevention of procedural thrombotic events with the use of anticoagulants occurs at the expense of severe bleeding complications. Hence, there has been a strong effort over recent years to develop and validate novel anticoagulant regimens that provide protection against thrombotic complications, but have only minor effects on normal haemostasis. Until recently, the standard anticoagulation therapy during PCI consisted in either unfractionated (UFH) or low-molecular-weight heparin (LMWH) that prevent coagulation indirectly by activation of antithrombin (AT). Once activated, AT inactivates thrombin and other proteases involved in blood clotting. However, only recently direct thrombin inhibitors (DTI) have been introduced as an alternative anticoagulant strategy in patients undergoing PCI. Bivalirudin is the most prominent member of the DTI class, directly inhibiting free- and clot-bound thrombin. Use of bivalirudin has recently been shown to result in a significant reduction of bleeding without an increase in thrombotic or ischaemic endpoints compared to heparin and glycoprotein (GP) IIb/IIIa inhibitors in patients presenting with acute coronary syndromes (ACS). This chapter will give an overview of the pharmacology and mechanism of action of bivalirudin and summarize results from recent clinical trials evaluating the use of bivalirudin in patients undergoing PCI.
APA, Harvard, Vancouver, ISO, and other styles
9

Schüpke, Stefanie, Steffen Massberg, and Adnan Kastrati. "The role of bivalirudin in percutaneous coronary intervention." In Oxford Textbook of Interventional Cardiology, edited by Simon Redwood, Nick Curzen, and Adrian Banning, 401–17. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198754152.003.0026.

Full text
Abstract:
Rapid progress has been made in interventional cardiology over the past years; many patients with coronary artery disease, even those with complex lesions, are nowadays being treated with percutaneous coronary intervention (PCI). As a result, a major focus of current cardiovascular research is on reducing negative periprocedural clinical events associated with PCI, particularly in high-risk patients. Among the most dangerous periprocedural events are thrombotic complications, leading to recurrent myocardial or cerebral ischaemia, often with fatal outcome. Anticoagulant and antiplatelet treatment, therefore, is an integral part of current PCI strategies. However, prevention of procedural thrombotic events with the use of anticoagulants occurs at the expense of severe bleeding complications. Hence, there has been a strong effort over the last few years to develop and validate novel anticoagulant regimens that provide protection against thrombotic complications, but have only minor effects on normal haemostasis. Parts of these efforts has also been the development of bivalirudin.
APA, Harvard, Vancouver, ISO, and other styles
10

Bing, Rong, David E. Newby, Jagat Narula, and Marc R. Dweck. "Non-invasive imaging of the vulnerable atherosclerotic plaque." In The ESC Textbook of Cardiovascular Imaging, edited by José Luis Zamorano, Jeroen J. Bax, Juhani Knuuti, Patrizio Lancellotti, Fausto J. Pinto, Bogdan A. Popescu, and Udo Sechtem, 467–80. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198849353.003.0032.

Full text
Abstract:
Cardiovascular disease remains the leading cause of death globally despite advances in medical therapy and risk stratification; ischaemic heart disease was responsible for an estimated 9.5 million deaths in 2016. To address this ongoing global burden of morbidity and mortality, there is a need for more sophisticated methods of diagnosis and prognostication, above and beyond clinical risk scores alone. The majority of myocardial infarction occurs due to ruptured atherosclerotic plaque, leading to acute thrombosis and coronary occlusion. For decades, the concept of the vulnerable plaque—plaques prone to rupture or thrombotic complications—has been central to our understanding of the pathophysiology of acute coronary syndromes. More recently, there has been a shift towards identifying the vulnerable patient through assessment of total atherosclerotic disease burden, in recognition of the fact that most plaque rupture events do not lead to clinical events. Moreover, demonstrating a strong causal link between vulnerable plaques and clinical events has previously proven difficult due to limitations in available invasive and non-invasive imaging modalities. However, we now have an array of imaging techniques that hold great potential for the advancement of vulnerable plaque imaging. These modalities are the subject of state-of-the-art clinical research, aiming to develop the role of atherosclerotic plaque imaging in modern clinical practice and ultimately to improve patient outcomes.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Ischaemic stroke research' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography