Relevant bibliographies by topics / Irreversible inhibitor

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Academic literature on the topic 'Irreversible inhibitor'

Author: Grafiati
Published: 25 May 2024

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Dissertations / Theses on the topic "Irreversible inhibitor"

1

Büchold, Christian. "Synthese und Testung cis-konfigurierter Aziridine als pseudo-irreversible Inhibitoren der sekretorischen Aspartatproteasen von Candida albicans." kostenfrei, 2009. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2009/3935/.

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2

Smar, Michael William. "Part 1: Reversible and irreversible inhibitors of aldose reductase as probes of the inhibitor binding site. Part 2: Synthesis of permanently charged and permanently uncharged dopamine agonists /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487597424138323.

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Borrello, Maria Teresa. "Reversible and irreversible LSD1 inhibitors." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/59682/.

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Environmental factors and lifestyle can alter the way our genes are expressed influencing a network of chemical switches within our cells collectively known as the Epigenome. Among the epigenetic mechanisms orchestrating the gene expression, methylation is of foremost importance and probably fair to say, still incompletely decoded. Dysregulations of histone methylation patterns lead to the repression or activation of signalling pathways that often promote the genesis and progression of disease states. Lysine specific demethylase 1 (LSD1) oxidatively removes methyl groups from histone H3 and it
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4

Burger, Alain. "Inhibiteurs irreversibles de la biosynthese de l'ecdysone." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13081.

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Coxon, Christopher Robert. "Design and synthesis of irreversible inhibitors of Nek2 kinase." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627743.

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Snider, Catherine E. "Synthesis and biochemical evaluation of irreversible inhibitors of aromatase /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266362338344.

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7

Berabez, Rayan. "Conception et validation préclinique de nouveaux inhibiteurs de LIMK pour le traitement de la Neurofibromatose de type 1." Electronic Thesis or Diss., Orléans, 2023. http://www.theses.fr/2023ORLE1070.

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La neurofibromatose de type 1 (NF1) est une maladie génétique qui se manifeste entre autre par l'apparition de tumeurs bénignes localisées au niveaux des terminaux nerveux appelés neurofibromes cutanés (NFc). Au cours de ces dernières années, de nouvelles cibles thérapeutiques sont apparues telles que les LIM kinases (LIMKs), enzymes responsables du dynamisme du cytosquelette et dont la suractivation est liée à différentes pathologies comme la NF1, le glioblastome ou l'ostéosarcome. Un travail de chimie médicinale a été donc initié dans le but de concevoir de nouveaux inhibiteurs sélectifs des
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8

Äbelö, Angela. "Pharmacodynamic Modelling of Irreversible and Reversible Gastric Proton Pump Inhibitors." Doctoral thesis, Uppsala University, Division of Pharmacokinetics and Drug Therapy, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3778.

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<p>Acid related diseases like GERD, duodenal-and gastric ulcers and H. Pylori-positive peptic ulcer disease are primarily managed by reducing gastric acidity. Irreversible proton pump inhibitors (PPIs) inhibit gastric acid secretion effectively throughout the day by irreversibly inhibiting the gastric proton pump, H+, K+-ATPase, in the parietal cells. Reversible gastric proton pump inhibitors are under development, but have not yet reached clinical use.</p><p>The pharmacokinetic/pharmacodynamic (PK/PD) relationships of these compounds are nonlinear, with a delay in the effect-time profile comp
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9

Ekici, Ozlem Dogan. "Design, synthesis, and evaluation of novel irreversible inhibitors for caspases." Diss., Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/5333.

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Äbelö, Angela. "Pharmacodynamic modelling of irreversible and reversible gastric proton pump inhibitors /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3778.

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