Relevant bibliographies by topics / Iron nanoparticles

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  2. Dissertations / Theses
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  5. Conference papers
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Academic literature on the topic 'Iron nanoparticles'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 September 2023

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Journal articles on the topic "Iron nanoparticles"

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Saleh, Lina, Eman A. Ragab, Heba K. Abdelhakim, Sabrein H. Mohamed, and Zainab Zakaria. "Evaluation of Anticancer Activities of Gallic Acid and Tartaric Acid Vectorized on Iron Oxide Nanoparticles." Drug Delivery Letters 10, no. 2 (April 26, 2020): 123–32. http://dx.doi.org/10.2174/2210303109666190903161313.

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Background: Cancer is one of the leading causes of death. New tactics targeting the survival pathways that provide effective drugs are being developed. Objective: Super paramagnetic nanoparticle serves as drug carrier for drug delivery system. Herein, Iron oxide-CMC-TA and Iron oxide-CMC-GA nanoparticles are synthesized for this target. Methods: Iron oxide (Fe2O3) nanoparticles are synthesized, bound to carboxymethyl chitosan (CMC) which are then conjugated to tartaric acid (TA) or gallic acid (GA) to form Iron oxide-CMC-TA and Iron oxide-CMC-GA nanoparticles. Those nanoparticles were characterized and the cytotoxicity effect was evaluated when associated with/without bee venom to measure the synergistic effect on A549 and WI-38 cell lines. In addition, apoptotic genes expression in A549 was evaluated when treated with both nanoparticles. Results: We showed that the cytotoxicity effect of TA and GA on A549 and WI-38 cell lines was increased when they immobilized on iron oxide-CMC nanoparticles and the effect was synergistically elevated when added to bee venom. The cytotoxic activity of these two nanoparticles was higher in A549 cancer cell line when compared with WI-38 normal cell line. Moreover, the expression of apoptotic genes was elevated. Conclusion: Iron oxide-CMC-TA nanoparticle and Iron oxide-CMC-GA nanoparticle can selectively induce apoptosis in cancer cell lines more than in normal cell lines, which is an important aspect in cancer cell targeting process to minimize damage upon normal cells.
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Nwauzor, J. N., A. J. Ekpunobi, and A. D. Babalola. "Processing and Characterization of Iron Oxide Nanoparticle Produced by Ball Milling Technique." Asian Journal of Physical and Chemical Sciences 11, no. 1 (March 21, 2023): 27–35. http://dx.doi.org/10.9734/ajopacs/2023/v11i1193.

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In this study iron oxide (Fe2O3) nanoparticle samples was prepared using mechanical grinding method. The optical properties were studied using UV-Vis spectrophotometer within a range of 200-1100nm. The micro and crystalline size of the nanoparticle were studied using x-ray diffractometer (XRD) and scanning electron microscopy (SEM). The compositional analysis was carried out using energy dispersive x-ray spectroscopy (EDXS). Observation of the electrical properties of the nanoparticle was carried out using an electrical four-point probe system. The XRD pattern in the 2θ range from 20 to 700 revealed that iron oxide had a rhombohedral structure. The SEM result showed that the nanoparticles were well dispersed and had a uniform crystalline structure. The EDXS results showed the elemental analysis of the nanoparticles under consideration. Iron oxide nanoparticles had elemental composition of oxygen, iron, titanium and carbon. The atomic and weight concentration of iron was 14.19 and 30.89%. The four-point probe electrical resistivity result shows that iron oxide nanoparticles had a sheet resistance of 9.8x106Ώ/sq. The optical result made it known that iron oxide nanoparticles possessed a high transmittance, also iron oxide nanoparticles displayed a low reflectance and moderate absorbance. Finally, the bandgap energy of Fe2O3 dispersed in ethanol was found to be 2.74 eV. The Band gap of Fe2O3 dispersed in distilled water is 2.98 eV.
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V. G., Viju Kumar, and Ananthu A. Prem. "Green Synthesis and Characterization of Iron Oxide Nanoparticles Using Phyllanthus Niruri Extract." Oriental Journal of Chemistry 34, no. 5 (October 17, 2018): 2583–89. http://dx.doi.org/10.13005/ojc/340547.

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Studies on green synthesis of nanoparticles moves forward a lot on these days. The present work involves the green method of synthesizing iron oxide nanoparticle from Phyllanthus niruri leaf extract. Furthermore, the green synthesized iron oxide nanoparticles were characterized and its antimicrobial activity was investigated. A characteristic comparison with chemical method of synthesis is also done, for iron nanoparticles. The characterization of nanoparticle includes the IR, UV-Vis, surface morphology and size determination using TEM, SEM, and XRD. The analytical studies revealed that the synthesized iron oxide nanoparticles from these two different methods have almost identical size and morphology. The synthesized iron oxide nanoparticles showed significant antimicrobial activity against the microbes, E. coli and P. aeroginosa. The studies concluded that the synthesis of iron oxide nanoparticles using plant extracts is more beneficial as it is an economical, energy efficient, low cost and environment-friendly process than the bio hazardous chemical synthesis. The present investigation may be a definite contribution to green chemistry in general and nano synthesis in particular.
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Góral, Dariusz, Andrzej Marczuk, Małgorzata Góral-Kowalczyk, Iryna Koval, and Dariusz Andrejko. "Application of Iron Nanoparticle-Based Materials in the Food Industry." Materials 16, no. 2 (January 12, 2023): 780. http://dx.doi.org/10.3390/ma16020780.

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Due to their different properties compared to other materials, nanoparticles of iron and iron oxides are increasingly used in the food industry. Food technologists have especially paid attention to their ease of separation by magnetic fields and biocompatibility. Unfortunately, the consumption of increasing amounts of nanoparticles has raised concerns about their biotoxicity. Hence, knowledge about the applicability of iron nanoparticle-based materials in the food industry is needed not only among scientists, but also among all individuals who are involved in food production. The first part of this article describes typical methods of obtaining iron nanoparticles using chemical synthesis and so-called green chemistry. The second part of this article describes the use of iron nanoparticles and iron nanoparticle-based materials for active packaging, including the ability to eliminate oxygen and antimicrobial activity. Then, the possibilities of using the magnetic properties of iron nano-oxides for enzyme immobilization, food analysis, protein purification and mycotoxin and histamine removal from food are described. Other described applications of materials based on iron nanoparticles are the production of artificial enzymes, process control, food fortification and preserving food in a supercooled state. The third part of the article analyzes the biocompatibility of iron nanoparticles, their impact on the human body and the safety of their use.
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Abdul Rahim Arifin, Azdiya Suhada, Ismayadi Ismail, Abdul Halim Abdullah, Farah Nabilah Shafiee, Rodziah Nazlan, and Idza Riati Ibrahim. "Iron Oxide Nanoparticles Derived from Mill Scale Waste as Potential Scavenging Agent in Dye Wastewater Treatment for Batik Industry." Solid State Phenomena 268 (October 2017): 393–98. http://dx.doi.org/10.4028/www.scientific.net/ssp.268.393.

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In this work, iron oxide were derived from millscale has been used as a potential scavenging agent in wastewater treatment due to its high adsorption capacity and its shorter sedimentation time during wastewater treatment. Iron oxide obtained from the magnetic separation technique was subjected to high energy ball milling (HEBM) at different milling time to produce different size of nanoparticles of iron oxide. X-ray diffraction (XRD), Field Emission Scanning Electron Microscope (FESEM) and Scanning Trasmission Electron microscopy (STEM) were performed to study the morphological properties of the iron oxide nanoparticles. After HEBM, iron oxide nanoparticles was modified with Hexadecyltrimethylammonium Bromide (CTAB) to study the adsorption possibility of iron oxide nanoparticle modified with CTAB (Iron oxide– CTAB nanoparticles) in dye wastewater. The variation effect of particle size of derived Iron oxide– CTAB were studied. Permanent magnet was used to separate iron oxide nanoparticles from the solution. The clear part of the solution (treated wastewater) was filtered out and adsorption efficiency of Iron oxide– CTAB nanoparticles was measured using UV – Visible spectroscopy. Efficiency adsorption of iron oxide nanoparticles modified with CTAB greatly achieved above 99 % and the size of iron oxide nanoparticles affected its performance in dye wastewater treatment.
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Rathi, C. R., and S. N. Suresh. "Mirabilis jalapa Flower Extract as Therapeutic Agent and Cellular Delivery by Nanoparticles." Journal of Drug Delivery and Therapeutics 11, no. 1-s (February 15, 2021): 53–56. http://dx.doi.org/10.22270/jddt.v11i1-s.4549.

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Bio friendly green modest syntheses of nanoparticles are the present research in the extremity of nanotechnology. This study has been undertaken to explore the determinants of iron nanoparticles from 1 mM FeSO4 solution through profuse concentration of aqueous flower extract of Mirabilis jalapa reducing besides immobilizing agent. The attribute of iron nanoparticles was studied by using UV-VIS spectroscopy SEM and XRD. The XRD spectrum of the iron nanoparticles established the presence of elemental copper signal. Green synthesized iron nanoparticle manifests the zone of inhibition against isolated human pathogenic (Streptococcus species, Bacillus species, Staphylococcus species, Klebsiella species and E. coli) bacteria. The analytical chassis contains the flower pigment betalain the natural food dye resources can efficiently use in the production of iron nanoparticle and it could be utilized in various fields in therapeutics and nanotechnology. Keywords: Nanoparticles, Mirabilis jalapa, UV-VIS spectroscopy, SEM- XRD.
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Buarki, F., H. AbuHassan, F. Al Hannan, and F. Z. Henari. "Green Synthesis of Iron Oxide Nanoparticles Using Hibiscus rosa sinensis Flowers and Their Antibacterial Activity." Journal of Nanotechnology 2022 (March 10, 2022): 1–6. http://dx.doi.org/10.1155/2022/5474645.

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Iron oxide nanoparticles (α- Fe2O3) were synthesized using an unconventional, eco-friendly technique utilizing a Hibiscus rosa sinensis flower (common name, China rose) extract as a reducer and stabilizer agent. The microwave method was successfully used for the synthesis of iron oxide nanoparticles. Various volume ratios of iron chloride tetrahydrate to the extract were taken and heated by the microwave oven for different periods to optimize iron oxide nanoparticle production. The synthesized iron oxide nanoparticles were characterized using the ultraviolet-visible spectrometer (UV-Vis), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and X-ray diffraction (XRD). X-ray diffraction confirmed the formation of α- Fe2O3 nanoparticles (hematite). The average size of iron oxide nanoparticles was found to be 51 nm. The antibacterial activity of the synthesized iron nanoparticles was investigated against different bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, and Escherichia coli. The results showed that the synthesized iron nanoparticles exhibited an inhabitation effect on all studied bacteria.
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Kim, Se-Ho, Ji Yeong Lee, Jae-Pyoung Ahn, and Pyuck-Pa Choi. "Fabrication of Atom Probe Tomography Specimens from Nanoparticles Using a Fusible Bi–In–Sn Alloy as an Embedding Medium." Microscopy and Microanalysis 25, no. 2 (February 4, 2019): 438–46. http://dx.doi.org/10.1017/s1431927618015556.

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AbstractWe propose a new method for preparing atom probe tomography specimens from nanoparticles using a fusible bismuth–indium–tin alloy as an embedding medium. Iron nanoparticles synthesized by the sodium borohydride reduction method were chosen as a model system. The as-synthesized iron nanoparticles were embedded within the fusible alloy using focused ion beam milling and ion-milled to needle-shaped atom probe specimens under cryogenic conditions. An atom probe analysis revealed boron atoms in a detected iron nanoparticle, indicating that boron from the sodium borohydride reductant was incorporated into the nanoparticle during its synthesis.
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Shalimba, Veikko, and Vít Sopko. "JATROPHA OIL WITH IRON NANOPARTICLES APPLICATION IN DRILLING PROCESSES." Acta Polytechnica 59, no. 3 (July 1, 2019): 299–304. http://dx.doi.org/10.14311/ap.2019.59.0299.

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A performance of heat transfer fluids has a substantial influence on the size, weight and cost of heat transfer systems, therefore, a high-performance heat transfer fluid is very important in many industries. Over the last decades, nanofluids have been developed. According to many researchers and publications on nanofluids, it is evident that nanofluids have a high thermal conductivity. The aim of this experimental study was to investigate the change of the workpiece temperature during drilling using Jatropha oil with iron nanoparticles and water with iron nanoparticles as lubricating and cooling fluids. These experiments were carried out with samples of nanofluid with different nanoparticles volume ratio, such as samples JN1, JN5 and JN10 of iron nanoparticles in the base Jatropha oil with a nanoparticle volume fraction of 1 %, 5% and 10% respectively and samples WN1, WN5 and WN10 of iron nanoparticles in the base water with a nanoparticle volume fraction of 1 %, 5% and 10% respectively.
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von der Heyden, Bjorn, Alakendra Roychoudhury, and Satish Myneni. "Iron-Rich Nanoparticles in Natural Aquatic Environments." Minerals 9, no. 5 (May 11, 2019): 287. http://dx.doi.org/10.3390/min9050287.

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Naturally-occurring iron nanoparticles constitute a quantitatively-important and biogeochemically-active component of the broader Earth ecosystem. Yet detailed insights into their chemical speciation is sparse compared to the body of work conducted on engineered Fe nanoparticles. The present contribution briefly reviews the analytical approaches that can be used to characterize natural Fe nanoparticles, before detailing a dedicated synchrotron-based X-ray spectro-microscopic investigation into the speciation of suspended Fe nanoparticles collected from fluvial, marine, and lacustrine surface waters. Ferrous, ferric and magnetite classes of Fe nanoparticles (10–100 nm) were identified, and all three classes exhibited a high degree of heterogeneity in the local bonding environment around the Fe center. The heterogeneity is attributed to the possible presence of nanoparticle aggregates, and to the low degrees of crystallinity and ubiquitous presence of impurities (Al and organic moieties) in natural samples. This heterogeneity further precludes a spectroscopic distinction between the Fe nanoparticles and the larger sized Fe-rich particles that were evaluated. The presented results provide an important baseline for natural nanoparticle speciation in pristine aquatic systems, highlight the degree of inter-particle variability, which should be parameterized in future accurate biogeochemical models, and may inform predictions of the fate of released engineered Fe nanoparticles as they evolve and transform in natural systems.
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Dissertations / Theses on the topic "Iron nanoparticles"

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Almeelbi, Talal Bakheet. "Phosphate Removal and Recovery Using Iron Nanoparticles and Iron Cross-Linked Biopolymer." Diss., North Dakota State University, 2012. https://hdl.handle.net/10365/26517.

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Nanoscale zero-valent iron (NZVI) particles and iron cross-linked alginate (FCA) beads were successfully used for the first time for phosphate removal and recovery. NZVI was successfully used for phosphate removal and recovery. Batch studies indicated a removal of ~96 to 100% phosphate in 30 min (1, 5, and 10 mg PO43--P/L with 400 mg NZVI/L). Phosphate removal efficiency by NZVI was 13.9 times higher compared to Microscale ZVI (MZVI) particles. The successful rapid removal of phosphate by NZVI from aqueous solution is expected to have great ramification for cleaning up nutrient rich waters. The presence of sulfate, nitrate, and humic substances and the change in ionic strength in the water marginally affected phosphate removal by NZVI. A maximum phosphate recovery of ~78% was achieved in 30 min at pH 12. Novel iron cross-linked alginate (FCA) beads were synthesized, characterized and used for phosphate removal. The beads removed up to 37-100% phosphate from aqueous solution in 24 h. Freundlich isotherm was found to most closely fit with experimental data and the maximum adsorption capacity was found to be 14.77 mg/g of dry beads. The presence of chloride, bicarbonate, sulfate, nitrate, and natural organic matters in aqueous solution did not interfere in phosphate removal by FCA beads. The phosphate removal efficacy FCA beads was not affected due to change in pH (4-9). Nanosacle zero-valent iron (NZVI) and iron cross-linked alginate beads were also tested for phosphate removal using actual wastewater treatment plant effluent and animal feedlot runoff. The FCA beads could remove ~63% and ~77% phosphate from wastewater and feedlot runoff in 15 min, respectively. Bioavailability of phosphate was examined using algae and higher plants. Phosphate and iron bioavailability of the NZVI sorbed phosphate was examined by supplying spent particles (NZVI with sorbed phosphate) to Tyee Spinach (Spinacia oleracea) and algae (Selenastrum capricornutum). Results revealed that the phosphate was bioavailable for both the algae and spinach. Also, presence of the nanoparticles enhanced the algae growth and plant growth and increases in biomass and plant length were observed. Iron (from spent NZVI) was found to be bioavailable for spinach.
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Carenza, Elisa. "Engineering Iron Oxide Nanoparticles For Angiogenic Therapies." Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/284861.

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El trabajo de investigación se ha desarrollado conjuntamente en el Instituto de Ciencia de Materiales de Barcelona (ICMAB-CSIC) y en el Instituto de Investigación del Hospital Universitario Vall d’Hebron (VHIR) en Barcelona. El trabajo se enmarca dentro del contexto tanto de nanomateriales como de nanomedicina. El objetivo principal de la tesis doctoral es desarrollar materiales para terapias no invasivas encaminadas a potenciar la regeneración de vasos sanguinos después de un evento isquémico. Para ello se han utilizado nanopartículas magnéticas de oxido de hierro como instrumentos de visualización (“imaging” por resonancia magnética) y de acumulación de proteínas/células en tejidos específicos bajo la influencia de un campo magnético externo. Se han desarrollado dos estrategias: la primera introduciendo las nanopartículas magnéticas en células endoteliales progenitora y la segunda en nanocápsulas poliméricas junto a un factor de crecimiento vascular. La tesis está estructurada en seis capítulos: CAPÍTULO 1 Las nanopartículas superparamagnéticas de óxido de hierro (SPIONs) son conocidas en diagnosis clínico por utilizarse como agentes de contraste que permiten la visualización de los tejidos a través de resonancia magnética (MRI). El capítulo contiene una breve introducción a la nanotecnología y una presentación de las características magnéticas de los materiales. Además contiene una revisión de los métodos de síntesis de las nanopartículas superparamagnéticas de oxido de hierro. CAPÍTULO 2 Describe la síntesis de nanopartículas superparamagnéticas de oxido de hierro mediante dos técnicas: descomposición térmica y microonda. Ambos métodos nos permiten de obtener partículas monodispersas con tamaño inferior a 20 nm y con excelentes propiedades magnéticas. Se ha logrado estabilizar las partículas en agua y en distintos medios celulares mediante estabilizantes iónicos (hidróxido de tetrametilamonio y sodio citrato). CAPÍTULO 3 La isquemia cerebral se define como la obstrucción de arterias intracraneales, debida a trombos o émbolos, que producen una lesión en los tejidos no perfundidos por la sangre. La regeneración y reparación del tejido cerebral basadas en la mejora de la angiogénesis endógena podría convertirse en realidad en un futuro próximo, al haberse identificado células progenitoras endoteliales (EPCs) en individuos adultos. Las EPCs son células que pueden inducir neo-vascularización y/o remodelación de vasos mediante liberación de factores angiogénicos. Nuestro objetivo es potenciar la acción terapéutica de las EPCs guiándolas a áreas específicas del cerebro con un campo magnético externo para potenciar la regeneración cerebral después de un ictus. En este capítulo se describen los experimentos in vitro de marcaje celular, toxicidad y funcionalidad de células. Además se describe un experimento in vivo con modelos animales demostrando la acumulación de EPCs magnetizadas en la zona del cerebro en la que se aplicó un campo magnético externo. CAPÍTULO 4 Otra estrategia que se ha investigado consiste en encapsular factores de crecimientos junto con las nanopartículas magnéticas (SPIONs) en nanocápsulas biodegradables de polímero de ácido poli(D,L-láctico-co-glicólico) (PLGA), para que éstas puedan guiarse a la lesión cerebral mediante la aplicación de un campo magnético externo. Durante los meses de estancia en el grupo de la Ecole de Pharmacie Genève-Lausanne (EPGL) se empezó la síntesis de nanocápsulas poliméricas con SPIONs y proteínas modelos. Este capítulo describe la síntesis y las caracterizaciones de las nanocápsulas obtenidas. CAPÍTULO 5 Conclusiones: se detallan los resultados más importantes obtenidos en esta tesis. En la primera parte se evidencian los siguientes resultados: 1. Se han sintetizado nanopartículas de óxido de hierro biocompatibiles y con las características adecuadas para la terapia celular; 2. Se ha realizado un marcaje no tóxico de células endoteliales progenitoras con SPIONs. Además se han reportado diferentes eficiencias de marcaje celular dependiendo del tipo de EPCs (early- y outgrowth). También se ha evidenciado que la eficiencia del marcaje celular puede variar utilizando diferentes condiciones de tiempo de incubación, de concentración de SPIONs y de agregación de partículas en los medios cultivos. Aún así, no se ha reportado ningún cambio significativo en la capacidad de tubulogénesis (formación de conexiones inter-celulares) ni de migración en población outgrowth de células endoteliales progenitoras marcadas con SPIONs; 3. Se ha detectado un aumento en la liberación de factores de crecimiento angiogénicos en células outgrowth marcadas con SPIONs respecto a células outgrowth no marcadas; 4. En un estudio preliminar in vivo en ratones, se ha demostrado con éxito la migración y acumulación de células endoteliales progenitoras (poblaciones early), marcadas con SPIONs, en la zona del celebro próxima a la aplicación del campo magnético externo. En la segunda parte del trabajo de tesis se ha conseguido: 1. La síntesis de nanocápsulas de polímero biodegradable de ácido poli(D,L-láctico-co-glicólico), mediante un proceso de doble emulsión, con tamaños de partícula de 200 nm adecuadas para la administración sistémica; 2. Co-encapsulación de SPIONs y factor de crecimiento vascular endotelial (proteína comercial, recombinant human VEGF165) con buena eficiencia. 3. La proliferación de células endoteliales potenciada por la actividad biológica de VEGF165 encapsulado. CAPÍTULO 6 Contiene el curriculum del autor y los trabajos publicados durante el periodo de doctorado.
The research was developed at the Institute of Materials Science of Barcelona (ICMAB-CSIC) and the Research Institute at Hospital Vall d'Hebron (VHIR) in Barcelona. The main objective of the thesis is to develop materials for non-invasive therapies to promote blood vessel regeneration after an ischemic event. For that we used iron oxide magnetic nanoparticles for imaging (through Magnetic Resonance Imaging) and accumulation of proteins / cells into specific tissues under the influence of an external magnetic field. Two strategies have been developed: the first one by introducing magnetic nanoparticles in endothelial progenitor cells (EPCs) and the second one into polymeric nanocapsules together with a vascular growth factor. The thesis is organized in six chapters: CHAPTER 1 Superparamagnetic iron oxide nanoparticles (SPIONs) are known for their use in clinical diagnosis as contrast agents allowing the visualization of tissues through magnetic resonance imaging (MRI). The chapter contains a brief introduction to nanotechnology and a presentation of the magnetic properties of the materials. It also contains a review of the most common synthetic methods used to obtain superparamagnetic iron oxide nanoparticles. CHAPTER 2 In this chapter is described the synthesis of superparamagnetic iron oxide nanoparticles using two techniques: thermal decomposition and microwave assisted sol-gel route. Both methods allow to obtain monodisperse particles with size less than 20 nm and excellent magnetic properties. Particles have been successfully stabilized in water and different cell media by ionic stabilizers (tetramethylammonium hydroxide and sodium citrate). CHAPTER 3 Cerebral ischaemia is defined as the blockage of cerebral arteries, due to a thrombus or embolus, which produce tissue damage in the zone not perfused with blood. Brain tissue regeneration and repair, based on the improvement of endogenous angiogenesis, could become reality in the near future having identified endothelial progenitors (EPCs) cells in adults. The EPCs are cells that can induce revascularization and / or remodeling of blood vessels by release of angiogenic factors. Our goal is to enhance the therapeutic action of EPCs guiding them toward specific areas of the brain with an external magnetic field to enhance regeneration after cerebral stroke. Experiments of in vitro cell labeling, cell toxicity and functionality are described in this chapter. In addition we showed an in vivo experiment using animal models to demonstrate the accumulation of magnetized EPCs in the brain under a magnetic field due to an external magnet implantation. CHAPTER 4 Another strategy is to encapsulate growth factors together with magnetic nanoparticles (SPIONs) into biodegradable nanocapsules of poly (D,l-lactic-co-glycolic acid) (PLGA), so that these can be guided toward the brain injury by applying an external magnetic field. During the training period in the group of the Ecole de Pharmacie Genève-Lausanne (EPGL) I started the synthesis of polymeric nanocapsules with SPIONs and model proteins. This chapter describes the synthesis and characterization of the nanocapsules. CHAPTER 5 In this chapter are described the most important results obtained during the thesis. The first part regards the following results: 1. The attainment of biocompatible iron oxide nanoparticles suitable for cell therapy; 2. Non toxic labeling of endothelial progenitor cells with SPIONs. Furthermore different efficiencies in cell labeling have been reported depending on the type of EPC cell population (early - and outgrowth). It has also been shown that cell labeling efficiency may vary using different conditions of incubation time, concentration of SPIONs and particle aggregation in the culture media. Still, it has been reported no significant change in tubulogenesis (formation of inter- cellular connections) or migration ability in outgrowth EPC cell population labeled with SPIONs; 3. An increase in the release of angiogenic growth factors in outgrowth EPCs labeled with SPIONs compared to unlabeled cells; 4. A preliminary in vivo study in mice has demonstrated the migration and accumulation of endothelial progenitor cells (early populations) labeled with SPIONs in the area next to the application of the external magnetic field. In the second part of the thesis work have been achieved: 1. The synthesis of biodegradable poly (D,L-lactic - co- glycolic acid) nanocapsules by a double emulsion process, with particle sizes of 200 nm suitable for systemic administration; 2. Co- encapsulation of SPIONs and vascular endothelial growth factor (commercial protein, recombinant human VEGF165) with good efficiency. 3. Endothelial cell proliferation enhanced by the biological activity of VEGF165 encapsulated. CHAPTER 6 It contains the curriculum vitae of the author and the publications obtained during the PhD period.
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Howard, Luciano E. M. "Synthesis and characterisation of iron platinum nanoparticles." Thesis, Durham University, 2007. http://etheses.dur.ac.uk/2442/.

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This thesis investigates the synthesis and characterization of FePt nanoparticles, a material which is a promising candidate for use as an ultra-high density magnetic storage medium; relevant literature is reviewed in chapter one. Chapter two gives full details of the characterisation techniques and physical property measurements employed throughout the work described in the following chapters. This includes powder X-ray diffraction, SQUID magnetometry, transmission electron microscopy, extended X- ray fluorescence spectroscopy and Rutherford backscattering. Chapter three describes the synthesis and characterisation of FePt nanoparticles prepared by a route presented in the literature as well as one developed during this study. Chapter four describes a systematic investigation into the Rietveld refinement of powder X-ray diffraction data of iron platinum nanoparticles. From the study it is concluded which of the methodologies presented is most suitable for use in further work on iron platinum nanoparticle studies. Chapter five describes a number of in-situ variable temperature X-ray diffraction studies designed to investigate the order-disorder transition in FePt nanoparticles. A comparison between this transition in samples made via both synthetic routes discussed in chapter three is made before analysing in-depth data in order to provide information about the phase transition and its relationship with precise synthetic conditions. Chapter six describes work done on FePt nanoparticles to determine if EXAFS measurements can be obtained and modelled such that conclusions can be drawn as to the degree of order of samples prepared via different methods. Chapter seven describes a variety of magnetic studies designed to investigate the structure and properties of FePt nanoparticles. The first part of the chapter focuses on typical experiments and what use they are whilst the second part discusses the methodology and equipment required to study the phase transition of iron platinum nanoparticles, i.e. variable temperature magnetic studies.
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Stuart, Dale. "Heat Transfer Enhancement using Iron Oxide Nanoparticles." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/425.

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Two different iron oxide nanofluids were tested for heat transfer properties in industrial cooling systems. The nanofluids either had 30 nm particles with a wide size distribution to include particles greater than 1 micrometer or 15 nm particles with greater than 95% of the particles less than 33 nm. Calorimetry and thermal circuit modeling indicate that the 15 nm particle ferrofluid enhanced heat capacity. The smaller particle ferrofluid also demonstrated up to a 39% improvement in heat transfer, while the larger particle ferrofluid degraded the heat transfer performance. Particles from the larger particle ferrofluid were noted as settling out of a circulating system and therefore not participating in the bulk fluid properties. Application of 0.32% 15nm particles in an open cooling system improved cooling tower efficiency by 7.7% at a flow rate of 11.4 liter per minute and improved cooling tower efficiency by 3.3% at a flow rate of 22.7 liter per minute, while applying 0.53% 15 nm particles also improved cooling tower efficiency but was less effective than the lower concentration.
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Salazar, Alvarez German. "Synthesis, characterisation and applications of iron oxide nanoparticles." Doctoral thesis, KTH, Materials Science and Engineering, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-87.

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Further increase of erbium concentrations in Er-doped amplifiers and lasers is needed for the design of efficient, reliable, compact and cost-effective components for telecommunications and other photonic applications. However, this is hindered by Er concentration dependent loss mechanism known as upconversion. The upconversion arises due to non-radiative energy transfer (ET) interactions (migration and energy-transfer upconversion) among the Er ions exited to the metastable level that is used for amplification. The upconversion deteriorates the conversion efficiency of Er doped gain medium and may even totally quench the gain. The upconversion can be significantly intensified if the Er distribution in glass is non-uniform, which can be minimized by optimizing the fabrication process and the glass composition. The optimization requires detailed characterization techniques capable to distinguish between the effects caused by the uniformly distributed ions (homogeneous upconversion, HUC) and non-homogeneously distributed ions (pair induced quenching, PIQ)

The thesis deals with rigorous statistical modeling of the HUC and development of experimental methods that can provide accurate and detailed data about the upconversion, which are needed for the characterization of the upconversion.

The presented model interprets the homogenous upconversion as an interplay of ET interactions between randomly distributed Er ions, which is affected by stimulated emission/absorption of the radiation propagating in the medium. The model correspondingly uses the ET interactions parameters as the main modeling parameters.

The presented analytical model is verified by Monte-Carlo simulations. It explains strongly non-quadratic character of the upconversion observed in experiments and variety of the associated effects. The model is applicable to the interpretation of the upconversion measurements in various experimental conditions, which facilitates the upconversion characterization. The thesis also presents an advanced experimental method for accurate and detailed characterization of the upconversion in both continues-wave pumping conditions and during the decay of Er population inversion. Using the method the upconversion modeling is experimentally verified by correlating the measurements results with the modeling predictions in the whole range of the practical Er doping levels. This also allows to estimate the parameters for the ET interactions in silica. Finally, it is shown that the presented method can serve as a basis for discrimination of HUC and PIQ effects, which is crucial for optimizing the fabrication process and the glass composition.

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Zurkiya, Omar. "Magnetic Resonance Molecular Imaging Using Iron Oxide Nanoparticles." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/19848.

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Magnetic resonance imaging (MRI) is regularly used to obtain anatomical images, greatly advancing biomedical research and clinical health care today, but its full potential in providing functional, physiological, and molecular information is only beginning to emerge. The goal of magnetic resonance molecular imaging is to utilize MRI to acquire information on the molecular level. This dissertation is focused on ways to increase the use of MRI for molecular imaging using superparamagnetic iron oxide (SPIO) nanoparticle induced MRI contrast. This work is divided into three main sections: 1) Elucidation of the contribution of size and coating properties to magnetic nanoparticle induced proton relaxation. To maximize contrast generated without increasing particle size, new methods to increase effects on relaxivity must be developed. Experimental data obtained on a new class of biocompatible particles are presented, along with simulated data. The effects of coating size, proton exchange, and altered diffusion are examined. Simulations are presented confirming the effect of particle coatings on clustering-induced relaxivity changes, and an experimental system demonstrating the clustering effect is presented. 2) Development of a diffusion-dependent, off-resonance imaging protocol for magnetic nanoparticles. This work demonstrates an alternative approach, off-resonance saturation (ORS), for generating contrast sensitive to SPIO nanoparticles. This method leads to a calculated contrast that increases with SPIO concentration. Experimental data and a mathematical model demonstrate and characterize this diffusion-dependent, off-resonance effect. Dependence on off-resonance frequency and power are also investigated. 3) Development of a genetic MRI marker via in vivo magnetic nanoparticle synthesis. This work seeks to provide a gene expression marker for MRI based on bacterial magnetosomes, tiny magnets produced by naturally occurring magnetotactic bacteria. Here, magA is expressed in a commonly used human cell line, 293FT, resulting in the production of magnetic, iron oxide nanoparticles by these cells. MRI shows these particles can be formed in vivo utilizing endogenous iron and can be used to visualize cells positive for magA. These results demonstrate magA alone is sufficient to produce magnetic nanoparticles and that it is an appropriate candidate for an MRI reporter gene.
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Salazar-Alvarez, German. "Synthesis, characterisation and applications of iron oxide nanoparticles /." Stockholm, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-87.

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Harris, Steven Scott. "Adiabatic pulse preparation for imaging iron oxide nanoparticles." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/47555.

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Iron oxide nanoparticles are of great interest as contrast agents for research and potentially clinical molecular magnetic resonance imaging (MRI). Biochemically modifying the surface coatings of the particles with proteins and polysaccharides enhances their utility by improving cell receptor specificity, increasing uptake for cell labeling and adding therapeutic molecules. Together with the high contrast they produce in MR images, these characteristics promise an expanding role for iron oxide nanoparticles and molecular MR imaging for studying, diagnosing and treating diseases at the molecular level. However, these contrast agents produce areas of signal loss with traditional MRI sequences that are not specific to the nanoparticles and cannot easily quantify the contrast agent concentration. With the expanding role of iron oxide nanoparticles in molecular imaging, new methods are needed to produce a quantitative contrast that is specific to the iron oxide nanoparticle. This dissertation presents a new method for detecting and quantifying iron oxide nanoparticles using an adiabatic preparation pulse and the failure of the adiabatic condition for spins diffusing near the particles. In the first aim, the theoretical foundation of the work is presented, and a Monte Carlo simulation supporting the proposed mechanism of the contrast is described. Adiabatic pulse prepared imaging sequences are also developed for imaging at 3 Tesla and 9.4 Tesla to highlight the translational potential of the approach for clinical examinations and scientific research, and the linear correlation of the contrast with iron concentration ideal for quantification is presented. Further, the physical characteristics of the nanoparticles and the parameters of the MRI sequence are modified to characterize the approach. In the second aim, the contrast is characterized in more realistic phantoms and in vitro, and a method to more accurately quantify nanoparticle concentration in the presence of magnetization transfer is presented. Finally, accelerated imaging methods are implemented to acquire the adiabatic contrast in a time compatible with in vivo imaging, and the technique is evaluated in an in vivo model of quantitative iron oxide nanoparticle imaging. Together, these aims present a method using an adiabatic preparation pulse to generate an MR contrast based on the microscopic magnetic field gradients surrounding the iron oxide nanoparticles that is suitable for in vivo quantitative, molecular imaging.
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Iles, Gail N. "Magnetism of iron nanoparticles in rare Earth matrices." Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/4430.

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This thesis details three main studies. The first is an investigation of the effect of coating Fe nanoparticles in a gas to isolate the magnetic moments. An isolation or enhancement of the already increased magnetic moment of a Fe nanoparticle would have the potential for exploitation in high-moment materials. The two other investigations are of the behaviour of Fe nanoparticles in the rare earth matrices Ho and Dy. Transition metals and rare earth metals normally couple antiferromagnetically at their interface, however the intention of this work was to determine if this also happens when the Fe is incorporated as pre-formed clusters. The motivation for this is that if the interactions between the rare earth and the transition metal is switched to be ferromagnetic then the Curie temperature of the rare earth could be increased without a large decrease in its saturation magnetisation. Fe nanoparticles consisting of -200 atoms and -2nm in diameter were manufactured using a gas aggregation source then coated with H2(g). VSM, XMCD and TEM measurements were taken of these samples and the magnetic moment per atom of Fe was found to drop significantly compared to that of isolated clusters in Ag matrices. A comparative study using N2(g) was conducted yielding similar results. This is attributed to the gas permeating the whole cluster rather than forming a shell. Addition of atomic Fe to a rare earth matrix decreases the total magnetisation due to antiferromagnetic coupling. Fe nanoparticles deposited into rare earth matrices heavily quench the rare earth moment. Samples of 2-35% Fe by volume contain Fe nanoparticles large enough to disrupt the rare earth spin wave. The Fe nanoparticles couple ferrimagnetically to the rare earth producing the low overall magnetic moment. Several magnetic phase transitions were observed in all Fe/rare earth alloys. Structural measurements using EXAFS indicate that the Fe clusters may have changed to an expanded lattice within the Dy matrix.
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Chen, Suelin Ph D. Massachusetts Institute of Technology. "Polymer-coated iron oxide nanoparticles for medical imaging." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/59004.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2010.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student submitted PDF version of thesis.
Includes bibliographical references (p. 144-157).
One of the most versatile and safe materials used in medicine are polymer-coated iron oxide nanoparticles. This dissertation describes several formulations for in vivo imaging applications. The paramagnetic polymer-coated iron oxide nanoparticle aminoSPARK is used as a fluorescence-mediated tomography (FMT) imaging agent for stratification of prostate cancer tumors. This is achieved by conjugating it to a peptide that targets SPARC (secreted protein acidic rich in cysteine), a biomarker protein associated with aggressive forms of prostate cancer. Several types of polymer coatings for iron oxide nanoparticles have been systematically explored using a novel high-throughput screening technique to optimize coating chemistries and synthetic conditions to produce nanoparticles with maximum stability and ability to lower T2 contrast for MR imaging (R2, or relaxivity). Carboxymethyl dextran emerged from the screen as an ideal coating for superparamagnetic iron oxide nanoparticles. A commercially available, FDA-approved nanoparticle with similar surface chemistry, Feraheme, was chosen as a platform nanoparticle for further development. This work presents the first instance of chemical modification of Feraheme, making it more amenable to bioconjugation by converting its free carboxyl groups to free amine groups. This amine-functionalized Feraheme nanoparticle (amino-FH) is then used as a base nanoparticle to which various targeting and reporting functionalities can be added. A FH-based nanoparticle that can be used for cell loading is synthesized by covalently combining Feraheme with protamine, a pharmaceutical that also acts as a membrane translocating agent. A rhodamine-protamine conjugate is synthesized and then covalently bound to amino-FH using carbodiimide (CDI) chemistry. This results in a magnetofluorescent cell-labeling nanoparticle (ProRho-FH) that is readily taken up by mouse mesenchymal stem cells and U87 glioma cells. ProRho-FH can be used to non-invasively track cells for development and monitoring of cell-based therapies or for further investigation of biological mechanisms such as cell migration, tumor growth, and metastasis. This combination of two FDA-approved, commercially available materials to yield a superparamagnetic and fluorescent cell labeling nanoparticle is an excellent alternative to the recently discontinued Feridex. All polymer-coated iron oxide nanoparticles used in this dissertation were thoroughly characterized to fully understand their physicochemical and magnetic properties.
by Suelin Chen.
Ph.D.
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Books on the topic "Iron nanoparticles"

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Wigger, Henning. Environmental Release of and Exposure to Iron Oxide and Silver Nanoparticles. Wiesbaden: Springer Fachmedien Wiesbaden, 2017. http://dx.doi.org/10.1007/978-3-658-16791-2.

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Superparamagnetic iron oxide nanoparticles: Synthesis, surface engineering, cytotoxicity, and biomedical applications. New York: Nova Science Publishers, 2011.

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Huang, Xiao-Lan. Iron Oxide Nanoparticles. IntechOpen, 2022.

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Iron Oxide Nanoparticles [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.95129.

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Iron Oxide Nanoparticles for Biomedical Applications. Elsevier, 2018. http://dx.doi.org/10.1016/c2015-0-06003-8.

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Villegas, Patricia. Iron Oxide Nanoparticles and Their Applications. Nova Science Publishers, Incorporated, 2021.

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Villegas, Patricia. Iron Oxide Nanoparticles and Their Applications. Nova Science Publishers, Incorporated, 2021.

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Toxicity studies of polymer based superparagnetic iron oxide nanoparticles. España: Prensas de la Universidad de Zaragoza, 2015.

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Urtizberea, Ainhoa. Open problems in the magnetic behavior of iron-oxide nanoparticles. Prensas Universitarias de la Universidad de Zaragoza, 2011. http://dx.doi.org/10.26754/uz.978-84-15274-76-6.

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Laurent, Sophie, Ghenadii Korotcenkov, and Morteza Mahmoudi. Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application. Elsevier Science & Technology Books, 2017.

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Book chapters on the topic "Iron nanoparticles"

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Laurent, Sophie, Céline Henoumont, Dimitri Stanicki, Sébastien Boutry, Estelle Lipani, Sarah Belaid, Robert N. Muller, and Luce Vander Elst. "Superparamagnetic Iron Oxide Nanoparticles." In MRI Contrast Agents, 55–109. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-2529-7_5.

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Del Bianco, L., A. Hernando, and D. Fiorani. "Exchange Coupling in Iron and Iron/Oxide Nanogranular Systems." In Surface Effects in Magnetic Nanoparticles, 217–38. Boston, MA: Springer US, 2005. http://dx.doi.org/10.1007/0-387-26018-8_7.

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Zhang, Wei-xian, Jiasheng Cao, and Daniel Elliott. "Iron Nanoparticles for Site Remediation." In Nanotechnology and the Environment, 248–55. Washington, DC: American Chemical Society, 2004. http://dx.doi.org/10.1021/bk-2005-0890.ch033.

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McGachy, Lenka, Radek Škarohlíd, and Marek Martinec. "Iron Nanoparticles in Environmental Technology." In 21st Century Nanoscience – A Handbook, 15–1. Boca Raton, Florida : CRC Press, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429351587-15.

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Silva, Christopher Santos, Vinicius Marx Silva Delgado, Vitória de Oliveira Lourenço, Flávia Cristina Policarpo Tonelli, Larissa Cristiane Souza Prote, Celso Judson Tadeu Batista Ferreira, Danilo Roberto Carvalho Ferreira, et al. "Green Iron Nanoparticles for Nanoremediation." In Green Nanoremediation, 231–51. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-30558-0_10.

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Gil-Díaz, Mar, and M. Carmen Lobo. "Phytotoxicity of Nanoscale Zerovalent Iron (nZVI) in Remediation Strategies." In Phytotoxicity of Nanoparticles, 301–33. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-76708-6_13.

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Singh, Ritu, and Virendra Misra. "Stabilization of Zero-Valent Iron Nanoparticles: Role of Polymers and Surfactants." In Handbook of Nanoparticles, 985–1007. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-15338-4_44.

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Singh, Ritu, and Virendra Misra. "Stabilization of Zero-Valent Iron Nanoparticles: Role of Polymers and Surfactants." In Handbook of Nanoparticles, 1–19. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-13188-7_44-1.

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Singh, Ritu, and Virendra Misra. "Stabilization of Zero-Valent Iron Nanoparticles: Role of Polymers and Surfactants." In Handbook of Nanoparticles, 1–18. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-13188-7_44-2.

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Dussán, Kelly J., Ellen C. Giese, Gustavo N. A. Vieira, Lionete N. Lima, and Debora D. V. Silva. "Pharmaceutical and Biomedical Applications of Magnetic Iron-Oxide Nanoparticles." In Metal Nanoparticles in Pharma, 77–99. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-63790-7_5.

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Conference papers on the topic "Iron nanoparticles"

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SEMENOVA, E. M., S. A. VOROBYOVA, J. A. FEDOTOVA, and V. G. BAYEV. "IRON-PALLADIUM COMPOSITE NANOPARTICLES." In Proceedings of International Conference Nanomeeting – 2013. WORLD SCIENTIFIC, 2013. http://dx.doi.org/10.1142/9789814460187_0072.

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Buyukhatipoglu, Kivilcim, Tiffany A. Miller, and Alisa Morss Clyne. "Biocompatible, Superparamagnetic, Flame Synthesized Iron Oxide Nanoparticles: Cellular Uptake and Toxicity Studies." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-68049.

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Superparamagnetic iron oxide nanoparticles, including magnetite (Fe3O4), are widely used in applications such as targeted drug delivery, magnetic resonance imaging, tissue engineering, gene therapy, hyperthermic malignant cell treatment, and cell membrane manipulation. These nanoparticles are particularly interesting for in vivo and in vitro applications since they do not exhibit magnetic behavior once the magnetic field has been removed. In the current work, superparamagnetic iron oxide nanoparticles were produced using a flame synthesis method, which provides significant advantages over other material synthesis processes such as solgel processing, chemical vapor deposition, and laser ablation. Flame synthesis allows control of particle size, size distribution, phase and composition by altering flame operating conditions. Flame synthesis is further capable of commercial production rates with minimal post-processing of the final product materials. This study focuses on the interaction of flame synthesized iron oxide nanoparticles with porcine aortic endothelial cells and compares the results to those obtained using commercially available iron oxide nanoparticles. The materials characteristics of the flame synthesized iron oxide nanoparticles, including morphology, elemental composition, particle size, were analyzed by electron microscopy (TEM, ESEM, EDS), and Raman Spectroscopy. The data verified production of a heterogenous mixture of hematite and magnetite nanoparticles, which exhibit superparamagnetic properties. Monodisperse iron oxide particles of 6–12 nm diameter and aggregated clusters of these 6–12nm nanoparticles have been synthesized. Nanoparticle biocompatibility was assessed by incubating flame synthesized and commercially available iron oxide nanoparticles with endothelial cells for 24 hours. Both alamar blue and Live/Dead cell assays showed no significant toxicity difference between flame synthesized and commercially available nanoparticles. Cells exposed to both types of nanoparticles maintained membrane integrity, as indicated by minimal lactase dehydrogenase release. Endothelial cells imaged by ESEM and confirmed by EDS demonstrated that uncoated flame synthesized nanoparticles are ingested into cells in a similar manner to commercially available nanoparticles. These data suggest that flame synthesized iron oxide nanoparticles are comparable to commercially available nanoparticles for biological applications. Flame synthesis has the advantage of a relatively simple synthesis process with higher purity products and lower time and energy manufacturing costs. Future work will include functionalizing the nanoparticle surfaces for specific biological applications, including specific cell targeting and bioactive factor delivery.
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Sipkens, T. A., N. R. Singh, K. J. Daun, N. Bizmark, M. Ioannidis, J. T. Titantah, and M. Karttunen. "Time Resolved Laser Induced Incandescence for Sizing Aerosolized Iron Nanoparticles." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-38515.

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This paper summarizes the results of Time-Resolved Laser-Induced Incandescence (TiRe-LII) measurements of iron nanoparticles in He, Ne, Ar, N2, CO, CO2, and N2O. The iron nanoparticles are formed in solution and then aerosolized with a pneumatic atomizer using various carrier gases, so the nanoparticle size is the same for each aerosol and the TiRe-LII signal only differs due to the different thermal accommodation coefficient (TAC). Thermal accommodation coefficients for the Fe-Ar, and Fe-N2 aerosols, derived from molecular dynamics using ab initio potentials, are compared with values inferred from the TiRe-LII measurements.
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Yu, Miao, and Alisa Morss Clyne. "Dextran and PEG Coating Reduced Nanoparticle Toxicity to Cells." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80819.

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Iron oxide nanoparticles are of interest for drug delivery, since they can be targeted using a magnetic field. However, prior to using nanoparticles in vivo, they must be shown as relatively non-toxic to cells. We and others have shown that bare iron oxide nanoparticles are readily taken up by cells, where they catalyze production of highly toxic reactive oxygen species (ROS). This oxidative stress disrupts the cell cytoskeleton and alters cell mechanics. [1] Iron oxide nanoparticles under current development for in vivo biomedical applications are often coated with a polysaccharide (eg. dextran) or a polymer (eg. polyethylene glycol, PEG). Both the size and the surface coating of nanoparticle may play an important role in cell toxicity.
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Lin, Dong, Chang Ye, Sergey Suslov, Yiliang Liao, C. Richard Liu, and Gary J. Cheng. "Mechanism of Fatigue Performance Enhancement in a Superhard Nanoparticles Integrated Nanocomposites by a Hybrid Manufacturing Technique." In ASME 2013 International Manufacturing Science and Engineering Conference collocated with the 41st North American Manufacturing Research Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/msec2013-1040.

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A hybrid manufacturing process, which contains Laser Sintering (LS) and Laser shock peening (LSP), is introduced to generate iron-TiN nanoparticle nanocomposites. It is a two-step process including LS followed with LSP. Before LS, TiN nanoparticles mixed with iron powders are coated on samples surface. After LS, TiN nanoparticles are embedded into iron matrix to strengthen materials. Then LSP is performed to introduce work hardening and compressive residual stress. The existed nanoparticles increase the dislocation density and also help to pin the dislocation movement. Better residual stress stability under thermal annealing can be obtained by better dislocation movement stabilization, which is beneficial for fatigue performance.
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Yu, Miao, Vladimir Muzykantov, and Alisa Morss Clyne. "Iron Oxide Nanoparticles Are Less Toxic to Endothelial Cells When Coated With Dextran and Polyethylene Glycol." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53702.

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Iron oxide nanoparticles are of particular interest for drug delivery applications, since they can be targeted to a specific location using a magnetic field. We are interested in delivering drugs to atherosclerotic plaques via these nanoparticles. However, prior to using nanoparticles in vivo, they must be shown as relatively non-toxic to cells. We and others have shown that bare iron oxide nanoparticles are readily taken up by cells, where they catalyze production of highly toxic reactive oxygen species [1]. This oxidative stress disrupts the cell cytoskeleton, alters cell mechanics, and may change other critical cell functions. Iron oxide nanoparticles for in vivo biomedical applications are often coated with a polysaccharide (eg. dextran) or a polymer (eg. polyethylene glycol, PEG). Both the size and the surface coating of the nanoparticle play an important role in cell toxicity.
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Zeng, Q., I. Baker, J. A. Loudis, Y. F. Liao, and P. J. Hoopes. "Synthesis and heating effect of iron/iron oxide composite and iron oxide nanoparticles." In Biomedical Optics (BiOS) 2007, edited by Thomas P. Ryan. SPIE, 2007. http://dx.doi.org/10.1117/12.708182.

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Ogden, Sam G., David Lewis, and Joe G. Shapter. "Silane functionalisation of iron oxide nanoparticles." In Smart Materials, Nano-and Micro-Smart Systems, edited by Nicolas H. Voelcker and Helmut W. Thissen. SPIE, 2008. http://dx.doi.org/10.1117/12.810679.

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Alexandrescu, R., V. Bello, V. Bouzas, R. Costo, F. Dumitrache, M. A. García, R. Giorgi, et al. "Iron Oxide Materials Produced by Laser Pyrolysis." In BONSAI PROJECT SYMPOSIUM: BREAKTHROUGHS IN NANOPARTICLES FOR BIO-IMAGING. AIP, 2010. http://dx.doi.org/10.1063/1.3505075.

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Lombardo, Jeffrey J., Andrew C. Lysaght, Daniel G. Goberman, and Wilson K. S. Chiu. "Growth and Characterization of Iron Nanoparticle Catalysts for Nanomaterial Synthesis." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-68449.

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The properties and structure of nanoscale particles can vary widely from their bulk counterparts. In order to use nanoparticles effectively one must first have an understanding of their composition. In this study, Fe nanoparticles were grown on fused quartz substrates using a method that allows for varying particle size and surface coverage by altering the particle deposition time. The resulting particles were analyzed using x-ray photoelectron spectroscopy (XPS) in order to understand how nanoparticle composition evolves as a function of deposition time. In addition, atomic force microscopy (AFM) was used to correlate the changes in size and surface density of the Fe particles with the changes in the XPS spectra as deposition time was varied. Knowledge gained through this study will be used to optimize the growth of Fe nanoparticles for single-walled carbon nanotube (SWNT) synthesis.
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Reports on the topic "Iron nanoparticles"

1

Nuxoll, Eric E., Tsutomu Shimotori, William A. Arnold, and Edward L. Cussler. Iron Nanoparticles in Reactive Environmental Barriers. Office of Scientific and Technical Information (OSTI), September 2003. http://dx.doi.org/10.2172/836459.

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Mohar, Jacob Steven, Ekaterina Dolgopolova, and Jennifer Ann Hollingsworth. Size and Shape Control of Gallium-Iron Oxide Nanoparticles. Office of Scientific and Technical Information (OSTI), July 2019. http://dx.doi.org/10.2172/1545738.

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Attias, Andre-Jean, Kwang-Sup Lee, and Alex K. Jen. Coupling Graphene Sheets with Iron Oxide Nanoparticles for Energy Storage and Microelectronics. Fort Belvoir, VA: Defense Technical Information Center, August 2015. http://dx.doi.org/10.21236/ada636883.

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Dixon, David Adams. Final Report: The Impact of Carbonate on Surface Protonation, Electron Transfer and Crystallization Reactions in Iron Oxide Nanoparticles and Colloids. Office of Scientific and Technical Information (OSTI), July 2013. http://dx.doi.org/10.2172/1086712.

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Choudhary, Ruplal, Victor Rodov, Punit Kohli, Elena Poverenov, John Haddock, and Moshe Shemesh. Antimicrobial functionalized nanoparticles for enhancing food safety and quality. United States Department of Agriculture, January 2013. http://dx.doi.org/10.32747/2013.7598156.bard.

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Original objectives The general goal of the project was to utilize the bactericidal potential of curcumin- functionalizednanostructures (CFN) for reinforcement of food safety by developing active antimicrobial food-contact surfaces. In order to reach the goal, the following secondary tasks were pursued: (a) further enhancement of the CFN activity based on understanding their mode of action; (b) preparing efficient antimicrobial surfaces, investigating and optimizing their performance; (c) testing the efficacy of the antimicrobial surfaces in real food trials. Background to the topic The project dealt with reducing microbial food spoilage and safety hazards. Cross-contamination through food-contact surfaces is one of the major safety concerns, aggravated by bacterial biofilm formation. The project implemented nanotech methods to develop novel antimicrobial food-contact materials based on natural compounds. Food-grade phenylpropanoidcurcumin was chosen as the most promising active principle for this research. Major conclusions, solutions, achievements In agreement with the original plan, the following research tasks were performed. Optimization of particles structure and composition. Three types of curcumin-functionalizednanostructures were developed and tested: liposome-type polydiacetylenenanovesicles, surface- stabilized nanoparticles and methyl-β-cyclodextrin inclusion complexes (MBCD). The three types had similar minimal inhibitory concentration but different mode of action. Nanovesicles and inclusion complexes were bactericidal while the nanoparticlesbacteriostatic. The difference might be due to different paths of curcumin penetration into bacterial cell. Enhancing the antimicrobial efficacy of CFN by photosensitization. Light exposure strengthened the bactericidal efficacy of curcumin-MBCD inclusion complexes approximately three-fold and enhanced the bacterial death on curcumin-coated plastic surfaces. Investigating the mode of action of CFN. Toxicoproteomic study revealed oxidative stress in curcumin-treated cells of E. coli. In the dark, this effect was alleviated by cellular adaptive responses. Under light, the enhanced ROS burst overrode the cellular adaptive mechanisms, disrupted the iron metabolism and synthesis of Fe-S clusters, eventually leading to cell death. Developing industrially-feasible methods of binding CFN to food-contact surfaces. CFN binding methods were developed for various substrates: covalent binding (binding nanovesicles to glass, plastic and metal), sonochemical impregnation (binding nanoparticles to plastics) and electrostatic layer-by-layer coating (binding inclusion complexes to glass and plastics). Investigating the performance of CFN-coated surfaces. Flexible and rigid plastic materials and glass coated with CFN demonstrated bactericidal activity towards Gram-negative (E. coli) and Gram-positive (Bac. cereus) bacteria. In addition, CFN-impregnated plastic material inhibited bacterial attachment and biofilm development. Testing the efficacy of CFN in food preservation trials. Efficient cold pasteurization of tender coconut water inoculated with E. coli and Listeriamonocytogeneswas performed by circulation through a column filled with CFN-coated glass beads. Combination of curcumin coating with blue light prevented bacterial cross contamination of fresh-cut melons through plastic surfaces contaminated with E. coli or Bac. licheniformis. Furthermore, coating of strawberries with CFN reduced fruit spoilage during simulated transportation extending the shelf life by 2-3 days. Implications, both scientific and agricultural BARD Report - Project4680 Page 2 of 17 Antimicrobial food-contact nanomaterials based on natural active principles will preserve food quality and ensure safety. Understanding mode of antimicrobial action of curcumin will allow enhancing its dark efficacy, e.g. by targeting the microbial cellular adaptation mechanisms.
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The Reaction Specificity of Nanoparticles in Solution: Application to the Reaction of Nanoparticulate Iron and Iron-Bimetallic Compounds with Chlorinated Hydrocarbons and Oxyanions. Office of Scientific and Technical Information (OSTI), June 2005. http://dx.doi.org/10.2172/895568.

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