Journal articles on the topic 'Iris Grace'
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Scriven, Charles. "Grace and Good." Journal of Interdisciplinary Studies 29, no. 1 (2017): 159–80. http://dx.doi.org/10.5840/jis2017291/210.
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How does the question of grace--its reality or not--affect self-understanding and moral aspiration? Søren Kierkegaard believed that conviction of grace, or of divine kindness at the heart of things, is crucial for human flourishing. This notion serves as a lever for critical reflection on perspectives concerning the secular turn Charles Taylor and others describe. The essay contrasts Kierkegaard’s thought with Iris Murdoch, Philip Kitcher, and co-authors Hubert Dreyfus and Sean Dorrance Kelly. Each of the secular perspectives, it turns out, maps onto a different one of three “stages” of human development that precede Kierkegaard’s highest, or Christian, form of existence. This provides an angle for assessing secularism as reflected in three contrasting accounts. Kierkegaard’s elaboration of the Christian ideal, and the shortfalls he saw in earlier stages, become the basis for a “justification” of grace as a premise for the well-lived life.
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Tobji, Rachida, Wu Di, and Naeem Ayoub. "FMnet: Iris Segmentation and Recognition by Using Fully and Multi-Scale CNN for Biometric Security." Applied Sciences 9, no. 10 (May 17, 2019): 2042. http://dx.doi.org/10.3390/app9102042.
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In Deep Learning, recent works show that neural networks have a high potential in the field of biometric security. The advantage of using this type of architecture, in addition to being robust, is that the network learns the characteristic vectors by creating intelligent filters in an automatic way, grace to the layers of convolution. In this paper, we propose an algorithm “FMnet” for iris recognition by using Fully Convolutional Network (FCN) and Multi-scale Convolutional Neural Network (MCNN). By taking into considerations the property of Convolutional Neural Networks to learn and work at different resolutions, our proposed iris recognition method overcomes the existing issues in the classical methods which only use handcrafted features extraction, by performing features extraction and classification together. Our proposed algorithm shows better classification results as compared to the other state-of-the-art iris recognition approaches.
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Desmond, John F. "Review: The Language of Grace: Flannery O'connor, Walker Percy, and Iris Murdoch." Christianity & Literature 37, no. 2 (March 1988): 54–56. http://dx.doi.org/10.1177/014833318803700211.
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Braune, Camille. "From Inattentiveness Towards Moral Failures: Acknowledging Simone Weil in Iris Murdoch’s Literary Writings." Labyrinth 25, no. 2 (January 15, 2024): 47–73. http://dx.doi.org/10.25180/lj.v25i2.341.
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Simone Weil's ideas proved fundamental for Iris Murdoch, opening up a difficult path of thought for one rooted in the British philosophical tradition in the 1950s (Sim 1985, Bok 2005, Lovibond 2011a, Panizza 2022a, Mac Cumhaill and Wiseman 2022). Grasping the Weilian-inspired moral theory of attention sketched by Iris Murdoch is a prerequisite for comprehending the development of her moral ideas (Panizza 2015, Broackes 2012) and the form they may take in her literary writings (Griffin 1993, Morgan 2006). This paper argues that we can read an expression of Simone Weil in Iris Murdoch's novels which articulate her notions of grace and gravity, but also convey the Weilian insights that shape Murdoch's moral perfectionism. It investigates three of Murdoch's well-known male protagonists, i.e., Bradley Pearson, Charles Arrowby and Hilary Burde, so as to comprehend how their moral failures relate to a defective implementation of the concepts of love and attention as theorised by Simone Weil as leading to goodness. Hence, it offers a new examination of the way in which the Murdochian literary staging of inattention as a cause of moral deficiency reveals its Weilian-based ethics of attention.
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Feng, Chiang Ling. "The Mathematical Analysis and Classification Research of an Iris Data Set Using Binary Tree and Grey Relation Grade." Journal of Physics: Conference Series 2068, no. 1 (October 1, 2021): 012004. http://dx.doi.org/10.1088/1742-6596/2068/1/012004.
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Abstract The data from an Iris flower database is studied. The Iris database is the most commonly used database for machine learning algorithms. The Iris database was developed by Ronald Aylmer Fisher in 1936. The Iris database has 150 records in three categories: Iris Sentosa, Iris Versicolor and Iris Virginic. The database has four attributes: sepal length, sepal width, petal length and petal width. For the machine learning algorithm, 150 Iris flower databases are used. Of the 150 Iris in the Iris database, 80% are used as the training set and the remaining 20% Iris as the test set. In machine learning, to perform classification and discrimination is a complicated and difficult thing. In this study, a grey relation grade is used to extract the main features of the Iris flower and a Binary Tree [1] is used to classify the Irises. The results show that for the same specific attributes, grey relation grade extracts the main attributes and can be used in combination with a binary for classification.
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Rashid, Faisal, Maryam Jabbar, Naseer Fatima, Muhammad Siddique, Asia Hussain, and Khalid Waheed. "Effect of Change in Iris Color on Myopia." Pakistan Journal of Medical and Health Sciences 16, no. 4 (April 26, 2022): 289–91. http://dx.doi.org/10.53350/pjmhs22164289.
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Purpose: The purpose of this study was to determine the distribution of iris colour and its relationship to myopia. Methods: A multi-centered, multi-disciplined, cross-sessional study was conducted From March 2021 to December 2021. 300 individuals ranging in age from 11 to 25 years were selected through non-probability purposive sampling technique. All the patients had a maximum of 6 hours of screen time. Mild, moderate and severe degree of myopia was included. All subjects were examined for refraction, and slit lamp examination was performed to compare slit lamp photos to an iris colour grading scheme. Results: Of the 300 subjects 188 (62.66 %) of the participants were female, with mild 70(23 %), moderate 51(17%), and severe 67 (22.33 %) myopia, while 112 (37.33 %) of the participants were male, with mild 45(15 %), moderate 40(13.33%), and severe 27(9 %) myopia. 90% of the participants in the study had Grade 3, 4 and 5 iris color.Subjects with darker iris colors had more myopic refractive error. Study results indicate patients with Grade 5 iris color had a higher likelihood of becoming myopic (p 0.001). Conclusion: Darker iris color was linked to higher myopia-related refractive errors, even when other known myopia-related risk variables were taken into account. Keywords: Refractive Errors, Myopia, Iris , Risk factor
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Edwards, Melissa, David Cha, S. Krithika, Monique Johnson, and Esteban J. Parra. "Analysis of iris surface features in populations of diverse ancestry." Royal Society Open Science 3, no. 1 (January 2016): 150424. http://dx.doi.org/10.1098/rsos.150424.
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There are many textural elements that can be found in the human eye, including Fuchs’ crypts, Wolfflin nodules, pigment spots, contraction furrows and conjunctival melanosis. Although iris surface features have been well-studied in populations of European ancestry, the worldwide distribution of these traits is poorly understood. In this paper, we develop a new method of characterizing iris features from photographs of the iris. We then apply this method to a diverse sample of East Asian, European and South Asian ancestry. All five iris features showed significant differences in frequency between the three populations, indicating that iris features are largely population dependent. Although none of the features were correlated with each other in the East and South Asian groups, Fuchs’ crypts were significantly correlated with contraction furrows and pigment spots and contraction furrows were significantly associated with pigment spots in the European group. The genetic marker SEMA3A rs10235789 was significantly associated with Fuchs’ crypt grade in the European, East Asian and South Asian samples and a borderline association between TRAF3IP1 rs3739070 and contraction furrow grade was found in the European sample. The study of iris surface features in diverse populations may provide valuable information of forensic, biomedical and ophthalmological interest.
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Ishiguro, Atsushi, Hiroshi Nakatsumi, Tetsuhito Muranaka, Yasuyuki Kawamoto, Satoshi Yuki, Miki Tateyama, Atsushi Sato, et al. "HGCSG 1301: A multicenter, double-blind, randomized controlled phase II trial comparing Hange-shashin-to versus placebo to prevent diarrhea in patients with metastatic colorectal cancer treated with IRIS/Bev as second-line therapy—Updated analysis of antitumor efficacy." Journal of Clinical Oncology 38, no. 4_suppl (February 1, 2020): 108. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.108.
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108 Background: IRIS (irinotecan plus S-1) plus bevacizumab (IRIS/Bev) is one of the standard chemotherapies in Japan for metastatic colorectal cancer (mCRC) as the first-line or second-line therapy. The most frequent non-hematological adverse event of IRIS was diarrhea. Hange-shashin-to (HST) is a Kampo medicine which is used in Japan for the treatment of gastritis, stomatitis, and diarrhea. We conducted this study to evaluate the usefulness of HST to prevent diarrhea in patients with mCRC receiving IRIS/Bev as the second-line therapy. Methods: This trial was designed as a multicenter, randomized, double-blind, placebo-controlled study. We administrated HST 2.5g or placebo PO t.i.d. x 3 months from the first treatment course of IRIS/Bev. The primary endpoint is proportion of ≥grade 3 diarrhea assessed by CTCAE v4.0. This study is registered with UMIN-CTR, number UMIN000012276. Results: Between Jan 1, 2014 and Mar 31, 2017, 59 patients from 11 institutes in Japan were randomly assigned to receive HST (n = 28, Group H) or placebo (n = 29, Group P). The proportions of ≥grade 3 diarrhea was 10.7% in Group H and 13.8% in Group P (p = 1.00). The other major adverse events of ≥grade 3 in Group H vs Group P were fatigue (3.6% vs 10.3%), anorexia (14.3% vs 10.3%), and nausea (0.0% vs 3.4%). The overall response rate was 13.6% in Group H vs 7.7% in Group P (p = 0.65). There were not statistically significant differences in median progression-free survival (mPFS), median time to treatment failure (mTTF), and median overall survival (mOS) between Group H and Group P ( mPFS 7.9 vs 5.9 months; p = 0.35; mTTF 3.8 vs 5.6; p = 0.466; mOS 17.0 vs 15.3 months; p = 0.750). Conclusions: Prophylactic HST could not reduce the severity of diarrhea during IRIS/Bev. The update analysis of anti-tumor efficacy showed that IRIS/Bev had promising survival benefit but there is not statistically significant difference between HST and placebo. Clinical trial information: UMIN000012276.
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Fu, Lin, Qi Dai, Pengzhi Zhu, Xu Jia, Fangjun Bao, Xiaoyu Chen, Yana Fu, Hengli Lian, Weihua Yang, and Yufeng Ye. "Association between Iris Biological Features and Corneal Biomechanics in Myopic Eyes." Disease Markers 2021 (November 18, 2021): 1–6. http://dx.doi.org/10.1155/2021/5866267.
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Purpose. Iris biological features such as surface features and profile characteristics reflected the development of iris stroma and microvessels. Iris vessels and microcirculation are still lack of effective detection methods, and we can directly observe only the iris surface biological characteristics. This cross-sectional study evaluated the association between iris surface biological features and corneal biomechanics in young adults with myopia. Methods. We recruited 152 patients with myopia aged ≥18 years, from the Eye Hospital of Wenzhou Medical University, who had complete Corneal Visualization Scheimpflug Technology (Corvis ST) data and graded iris surface features. Iris surface features included crypts, furrows, and color measured from digital slit lamp images. The biomechanical properties of the cornea were assessed using Corvis ST. Only 1 eye of each participant was randomly selected for analysis. Associations between the iris surface features and corneal biomechanics were analyzed using linear regression models. The grade of iris crypts, furrows, and color and corneal biomechanical parameters measured with Corvis ST was the main outcome measures. Results. The iris crypts were significantly associated with deflection amplitude at the first applanation (A1 DLA, β = 0.001 , P = 0.013 ), A1 delta arc length (A1 dArcL) ( β = − 0.001 , P = 0.01 ), maximum delta arc length (dArcLM) ( β = − 0.004 , P = 0.03 ), and stiffness at the first applanation (SP-A1) ( β = − 2.092 , P = 0.016 ). The iris furrows were only associated with integrated radius ( β = − 0.212 , P = 0.025 ). Iris color was found not related with corneal biomechanical parameters measured via Corvis ST. Conclusions. Iris surface features were associated with corneal biomechanical properties in myopic eyes; more iris crypts were associated with lower corneal stiffness while more extensive furrows were related with higher corneal stiffness. Iris crypts and furrows may provide useful information on corneal biomechanical properties in myopic eyes.
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Russell, Carolyn, Barbara Griesheim, and Nancy Lee. "Teachers Use IRIs to Help Struggling Readers." Georgia Journal of Literacy 37, no. 2 (October 30, 2014): 13–17. http://dx.doi.org/10.56887/galiteracy.58.
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During the past few decades, an extraordinary amount of public attention has been given to controversies regarding how reading is being taught, is not being taught, or how it should be taught. To address reading concerns, publishers have developed commercial reading programs which provide teachers with materials on a variety of reading levels for use in the classroom. These materials allow teachers to match the reading levels of students with the appropriate reading books. Within a typical classroom, the reading ability of the students will range from below grade level to above grade level. In order to accurately select books that are on a student's reading level, a teacher must assess the student's reading skills. Betts (1950) developed a simple technique for using graded reading books to evaluate children's reading levels. The technique, which he called an "Informal Reading Inventory," involved selecting a short passage from grade level readers several grade levels below and above the student's grade level. Next, several comprehension questions were written for each passage. The student was to read the passages aloud and to answer the questions. Results of the oral reading and the comprehension questions are analyzed to determine the student's reading level.
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Moyle, Wendy, and Eric Purdy. "Nematode-Induced Low-Grade Chronic Inflammation of the Iris." Optometry and Vision Science 89, no. 6 (June 2012): E939—E943. http://dx.doi.org/10.1097/opx.0b013e318255d897.
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dos Santos Costa, Daniel, Rosalvo Ferreira de Oliveira Neto, Rodrigo Pereira Ramos, Victor Gustavo da Silva Oliveira, and Barbara Teruel. "IRIS-GRAPE: An approach for prediction of quality attributes in vineyard grapes inspired by iris biometric recognition." Computers and Electronics in Agriculture 168 (January 2020): 105140. http://dx.doi.org/10.1016/j.compag.2019.105140.
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Antipova, Ekaterina Alekseevna, Lyudmila Evdokimovna Kudrikova, Lyudmila Ivanovn Tikhomirova, Natalya Grigoryevna Bazarnova, Marina Yurievna Cheprasova, and Elena Pavlovna Khanutova. "ASSESSMENT OF THE CONTENT OF POLYPHENOLS IN BIOTECHNOLOGICAL RAW MATERIAL IRIS SIBIRICA L. STAR VARIETY IN COMPARISON WITH INTACT PLANTS." chemistry of plant raw material, no. 2 (April 1, 2019): 239–50. http://dx.doi.org/10.14258/jcprm.2019024799.
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Cultivation of plant raw materials in artificial conditions will inevitably lead to a change in the qualitative and quantitative composition of secondary metabolites in comparison with the composition of plants obtained in soil conditions. The study of the metabolic profile of such plants is very important on the one hand for our understanding of temporal (ontogenetic) and spatial changes in the metabolome of plants, on the other hand in the applied plan to obtain an alternative quality medicinal plant raw materials. In this regard, the aim of this study was to study the content of phenolic compounds in biotechnological raw materials Iris sibirica Grade Стерх in comparison with intact plants.
As objects of study used plants propagated mikrokanale (regenerants), which were further grown under conditions of hydroponics (hydroponic). Intact plants were harvested in the field at the age of six years. As a result of research in raw materials Iris sibirica Grade Стерх, grown under different conditions, were found following a group of biologically active compound (БАС), corresponding to the genus Iris L.: fenilpropionovoy acid (Komarova and ferulic acid and their derivatives), flavonoids (glycosides of apigenin, apigenin-7-O-glycoside), isoflavones, and phenolic acids (vanillic acid), neytralizuya flavonoids-glycosides (glycosides of kaempferol and apigenin), stilbene. The qualitative composition of biologically active compounds of Iris sibirica Стерх depended on the growing conditions, while the biotechnological raw materials (hydroponic plants) are the closest to intact plants in terms of the content of biologically active compounds. This allows us to consider the biotechnology of obtaining the raw material Iris sibirica L. based on hydroponic cultivation coupled with the micropropagation in an alternative way.
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Sri Saraswati, Putu Ayu, and Wira Gotera. "Grave’s Disease as A Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV Patients Who are Later Diagnosed with Cervical Cancer: A Case Report." International Journal of Research and Review 9, no. 8 (August 18, 2022): 393–98. http://dx.doi.org/10.52403/ijrr.20220832.
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Grave’s Disease (GD) after giving Active Antiretroviral Therapy (ART) to HIV patients is one of the manifestations of Immune Reconstruction Inflammatory Syndrome (IRIS). Complaints and clinical symptoms of Grave’s IRIS usually appear in 8-33 months since the use of ART. A 40-year-old woman was diagnosed with HIV with comorbid pulmonary tuberculosis (TB) infection. The patient regularly took ART and had finished taking TB drugs for 6 months, and the pulmonary TB was declared cured. However, the patient began to complain and showed clinical symptoms of hyperthyroidism. After receiving anti-thyroid medication, the patient has no complaints related to thyroid disease. Six months later, the patient experienced frequent vaginal bleeding. After being evaluated by the Obstetrics and Gynecology section, the patient was diagnosed with cervical cancer. Abnormality of thyroid function test in HIV patients was common, but only 1-2% of HIV patients showed signs of thyroid disorder. However, few cases still show GD as a manifestation of IRIS in HIV patients receiving ART. Dysregulation of the immune system in IRIS-HIV condition and long-standing inflammatory response of HIV (innate and adaptive immune cells involvement, MCH class I & MCH class II expression, TGFβ effect, immune-modulating drugs effect, and effect of reactive oxygen species) promote progression of cancer. Keywords: Grave Disease, IRIS, Cancer, HIV
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Shin, Jisoo, Taehong Kim, Byungjoon Lee, and Sunhee Yang. "IRIS-HiSA: Highly Scalable and Available Carrier-Grade SDN Controller Cluster." Mobile Networks and Applications 22, no. 5 (April 25, 2017): 894–905. http://dx.doi.org/10.1007/s11036-017-0853-6.
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Borodich, G. S. "EXPERIENCE OF INTRODUCTION OF IRIS DWARF (IRIS PUMILA) AND ITS VARIETIES IN BELARUS." Proceedings of the National Academy of Sciences of Belarus, Biological Series 63, no. 3 (August 25, 2018): 358–64. http://dx.doi.org/10.29235/1029-8940-2018-63-3-358-364.
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Information is given on geographical distribution and causes of decline of populations in the natural environment of protected species iris dwarf (I. pumila L.).Gives a brief description of the biological characteristics and the necessity of saving iris in Botanical gardens. Studied the adaptive properties of 5 samples of I. pumila of different geographical origin in the conditions of introduction in the Central Botanical garden of NAS of Belarus. Pronalazenje established phases of regeneration, budding, flowering and fruiting in the local context. Confirmed by literary data about the fragility of I. pumila in the culture: the plants fall to 3–4 year of life. The expediency of sexual reproduction dwarf iris in order to preserve the collection Fund. Tested 2 methods of seed propagation. The most interesting in the decorative plants. Evaluated the adaptive capacity of 8 varieties of miniature dwarf irises foreign selection, created with the participation of I. pumila. Conducted primary and comparative grade score, including ornamental and economic-biological features of varieties. Long-term observations revealed that in the conditions of introduction of miniature dwarf irises are all the stages of ontogenesis, yearly flower and fruit. Winter without shelter. Relatively resistant to diseases and pests. The use of wild I. pumila in gardening is limited by its biological features. Varieties, differing variety of colors, due to the early timing of flowering, abundant flowering and high rate of vegetative propagation is recommended for use in landscaping plantings.
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Komatsu, Yoshito, Satoshi Yuki, Takashi Kato, Ayumu Hosokawa, Ichiro Iwanaga, Osamu Muto, Kazuteru Hatanaka, Michio Nakamura, Yasushi Tsuji, and Yuh Sakata. "Safety report of a phase II trial of irinotecan plus S-1 (IRIS) with cetuximab in patients with KRAS wild type of metastatic colorectal cancer: HGCSG0902." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e14062-e14062. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e14062.
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e14062 Background: IRIS is one of the standard regimens as second line treatment in metastatic colorectal cancer since IRIS demonstrated the non-inferiority to FOLFIRI (FIRIS study) in Japan. We previously presented IRIS plus bevacizumab (ESMO 2010), however; there is still lack of combination data of IRIS plus molecular target drugs. Thus we conduct the study of IRIS plus cetuximab (HGCSG0902) and this is the planned safety analysis for first 20 patients. Methods: HGSCG0902 is a multicenter phase ll study. Eligibility includes histologically confirmed colorectal cancer, previously received oxaliplatin-contained chemotherapy, PS: 0-1, EGFR positive and KRAS wild type. Patients (pts) received S-1 80-120 mg/m2/day p.o. on days 1-14 and irinotecan 100mg/m2 on days 1 and 15 repeated 28 days. Cetuximab administrated 400mg/m2 loading dose and continued 250mg/m2 every week or 500mg/m2 bi-weekly. The primary endpoint was response rate and the secondary endpoints were disease control rate, PFS, OS and safety. Results: Demographics of the 20 enrolled pts were male/female: 13/7, median age: 64.5, colon/rectal: 13/7, PS0/1: 12/8, prior bevacizumab +/-: 15/4 pts. Cetixumab were administrated weelkly/bi-weekly: 9/11 pts. 70% of pts had adverse events (AE). The most common non-hematological AE were diarrhea (85%), acne-like rash (80%), fatigue (75%) and anorexia (60%) and hematological AE were anemia (90%), AST increase (75%) and ALT increase (70%). The main grade 3-4 AE were diarrhea (45%), acne-like rash (20%), anorexia (20%) and stomatitis (20%). These AE were as expected. Nineteen pts stopped the treatment due to progression (52.6%) and AE (36.8%). Conclusions: This safety analysis suggests that IRIS plus cetuximab is well-tolerated and easy to administer.
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Li, Xiaoli. "Ultrasound Biomicroscopy Diagnosis Analysis and Fine Care of Anterior Segment Injury of Traumatic Anterior Chamber Based on Intelligent Virtual Reality Technology." Journal of Healthcare Engineering 2021 (May 11, 2021): 1–12. http://dx.doi.org/10.1155/2021/9930686.
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The front part of the eye is exposed to the surface of the body, making it susceptible to injury. Blunt eye injuries often destroy the tissue structure in the anterior part of the eye. Often there is detachment of the iris root, separation of the ciliary body, the angle of retraction of the chamber, and complete dislocation or subluxation of the lens. Ordinary ocular ultrasound can penetrate into opaque tissue, but because of its low resolution, it can only show its outline, which is still very small for doctors in assisting diagnosis. Ultrasonic biomicroscopy is a very real-time analysis, will not be affected by the refraction space, and has great application value for ocular trauma. Based on this, this article proposes the ultrasound biomicroscope diagnosis analysis and fine nursing research of traumatic anterior chamber injury based on intelligent virtual reality technology. This article describes literature methods, experimental analysis methods, and other methods, in-depth study of the causes of traumatic anterior injuries, ultrasound biomicroscopy, and other theoretical knowledge, ultrasound biomicroscopy and microcontrol experiments for traumatic anterior injury design, and finally the causes of eye damage. This study compares the pairing results of ultrasound biomicroscopy biological measurements, analyzes the relationship between anterior bleeding level and anterior ocular injury, and analyzes the outcome and extent of service ophthalmology. The angle retreat accounted for 52.17% in grade I, 72.22% in grade II, and 60% in grade III. Anterior bleeding can cause single or complex iris root detachment, iris root detachment, ciliary body detachment, and angular leakage. The more the bleeding, the more serious the eye damage.
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Yuki, Satoshi, Yoshito Komatsu, Takuto Miyagishima, Takashi Kato, Kazuteru Hatanaka, Michio Nakamura, Mineo Kudo, Nobuaki Akakura, Miki Tateyama, and Yuh Sakata. "Phase II trial of combined chemotherapy with irinotecan, S-1, and bevacizumab (IRIS/Bev) in patients with metastatic colorectal cancer: Update analysis—Hokkaido Gastrointestinal Cancer Study Group (HGCSG) trial." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 3593. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.3593.
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3593 Background: The FIRIS study (Muro K et al. Lancet Oncol 2010;11:853–860) previously demonstrated the non-inferiority of Irinotecan plus S-1(IRIS) to FOLFIRI for metastatic colorectal cancer(mCRC), with progression-free survival (PFS) as the primary endpoint. We previously reported that IRIS plus bevacizumab(IRIS/bev) is very effective as first-line treatment (Komatsu Y et al. ESMO 2010). We now report the updated results of this study. Methods: Eligible patients had to have mCRC with a confirmed diagnosis of adenocarcinoma, an age of >20 years, ECOG performance status (PS) of 0-1, and no history of prior chemotherapy. S-1 40-60 mg twice daily p.o. was given on days 1-14 and irinotecan 100 mg/m2 and bevacizumab 5 mg/kg i.v. were given on days 1 and 15 of a 28-day cycle. The primary endpoint was safety. The secondary endpoints included overall response (OR), progression-free survival (PFS), and overall survival (OS). Results: The target number of 53 patients was enrolled as of March 2009. The results are reported for 52 patients with evaluable lesions. The clinical characteristics of the patients were as follows. The median age was 63.5 years (range, 48 to 82). The male:female ratio was 3:2. The performance status on the Eastern Cooperative Oncology Group scale was 0. In January 2012, on safety analysis, the incidence of grade 3 or 4 neutropenia was 27%. The incidences of other grade 3 or 4 adverse reactions were as follows: diarrhea, 17%; anorexia, 4%; stomatitis, 2%; hypertension, 21%; and gastrointestinal perforation, 0%. The overall response rate was 63.5%. Three patients had complete response. Thirty patients had partial response, 16 had stable disease, none had progressive disease, and 3 were not evaluable. Median progression-free survival was 17.0 months and median survival time was 39.6 months. Conclusions: IRIS/Bev is a remarkably active and generally well-tolerated first-line treatment for patients with mCRC. Randomized control trial comparing this regimen with oxaliplatin containing regimen(XELOX or mFOLFOX6 plus bevacizumab) is being planned.
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Kopaev, S. Yu, I. A. Il´inskaya, and A. A. Burtseva. "Surgical techniques of intraocular lens-capsular bag complex stabilization during cataract phacoemulsification in patients with lens subluxation." Kazan medical journal 100, no. 5 (October 14, 2019): 850–54. http://dx.doi.org/10.17816/kmj2019-850.
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Aim. To develop and to assess the efficacy of the method of one-step upper fixation of a single-piece intraocular lens to the iris during cataract phacoemulsification in patients with lens subluxation.
Methods. The study included 32 patients (37 eyes) with complicated cataract grade 23 combined with grade 12 lens subluxation. Both groups underwent cataract phacoemulsification with consequent implantation of a capsular tension ring and a single-piece intraocular lens. Group 1 (21 eyes) underwent intraoperative one-step upper haptic fixation of a single-piece intraocular lens in vertical position. In group 2 (16 eyes) in 13 cases 61.5 months later a single piece intraocular lens was repositioned and both haptics were sutured to the iris.
Results. In both groups no intraoperative complications occured. Visual acuity in group 1 on days 13 after the surgery was 0.770.19 and was stable during the follow-up. Intraocular pressure was 17.20.99 mm Hg. In group 2 the obtained good functional results 0.780.18 declined due to intraocular lens decentration, the intraocular pressure increased by 6.01.25 mm Hg (up to 24.20.65 mm Hg) which required an intraocular lens reposition in 81.3% of cases. According to ultrasound biomicroscopy, in both groups intraocular lens in all cases had intracapsular fixation and was in a central position.
Conclusion. The developed method of a one-step single piece intraocular lens fixation by suturing the upper haptic to the iris during cataract phacoemulsification in patients with lens subluxation is an effective and safe procedure that allows complete rehabilitation of patients with phacodonesis during a one-step surgical intervention.
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Tsatsaki, Niki, and Yannis Z. Tzifopoulos. "A New Epistomion from Sfakaki, near Rethymno." Trends in Classics 14, no. 1 (July 1, 2022): 124–38. http://dx.doi.org/10.1515/tc-2022-0005.
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Abstract Publication of a new gold epistomion unearthed during rescue excavations in the property of IRIS Hotel Inc. in the Sfakaki region near Rethymno. The new epistomion from Grave 7 belongs to category E, the so-called chaire-texts, and is identical to that incised on E4, bringing the total number of epistomia from Crete to sixteen (see Appendix).
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Placer, Margaret Amparo, and Cindy McManis. "Laparoscopic resection of bilateral perinephric pseudocyst in a pediatric feline patient." Journal of Feline Medicine and Surgery Open Reports 5, no. 1 (January 2019): 205511691985064. http://dx.doi.org/10.1177/2055116919850646.
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Case summary A 6-month-old male domestic shorthair cat presenting with abdominal distension and an acute history of renal azotemia was diagnosed with bilateral perinephric pseudocysts and International Renal Interest Society (IRIS) grade 3 acute kidney injury. Ultrasound-guided drainage of the cysts was performed initially; bilateral subtotal resection of the perinephric pseudocysts was later performed using laparoscopy as a more long-term solution. There was no regrowth or reformation of the perinephric pseudocysts 1 year after the procedure, and the cat remained in IRIS stage 2 chronic kidney disease 1 year postoperatively. Relevance and novel information Compared with traditional surgical approaches, laparoscopic resection of perinephric pseudocysts provides a less invasive approach. Bilateral perinephric pseudocyst in a pediatric feline patient (and associated treatment) has not previously been documented in the literature.
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Mahbub, S. M. A., Jamsed Faridi, Khair Ahmed Choudhury, Shovana Alam, Ashiqur Rahman Akanda, and Mahamud Adnan. "The Distribution of Iris Colour and Its Relationship to Myopiain Bangladeshi Patients." Saudi Journal of Medical and Pharmaceutical Sciences 9, no. 02 (February 25, 2023): 135–39. http://dx.doi.org/10.36348/sjmps.2023.v09i02.008.
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Background: Myopia, or nearsightedness, affects a large percentage of the population and is typically identified in those under the age of 20. Having myopia makes it difficult to see far away. While you have no issue seeing nearby items, such as those used to indicate aisles in a grocery store, you may have trouble seeing further away ones, such as road signs. Objective: In this study our main goal is to evaluate the distribution of iris colour and its relationship to myopiain Bangladeshi patients. Method: This cross-sectional study was carried out at tertiary hospital from March 2020 to December 2021, researchers from several fields and sessions worked together on a single unified study. There were a total of 100 people, with a best corrected visual acuity (BCVA) of 6/6, and ages ranging from 11 to 25 years old. Patients were limited to no more than six hours of television every day. All three degrees of myopia (mild, moderate, and severe) were covered. Results: During the study, 51% belong to 10-15 years followed by 35% belong to 16-20 years and 14% belong to 21-25 years. In addition, among patients mild 55%, moderate 21%, and severe 24% myopia. Screen time, significantly associated with myopia. 40% who had screen time was 1-2 hours had severe level myopia. Followed by 45% who had screen time was 2-4 hours had severe level myopia and 50% who had screen time was 4-6 hours had severe level myopia. 66% who had mid-level myopia had grade I Irish color. Followed by 56% who had moderate level myopia had grade I Irish color and 50% severe level myopia had grade I Irish color. 66% who had simple myopia had grade I Irish color. Followed by 55% who had curvatural myopia had grade I Irish color. Conclusion: Darker iris color was linked to higher myopia-related refractive errors, even when other known myopia-related risk variables were taken into account.
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Yuki, Satoshi, Yoshito Komatsu, Hiraku Fukushima, Takahide Sasaki, Toraji Amano, Takuto Miyagishima, Kazuteru Hatanaka, Michio Nakamura, Miki Tateyama, and Yuh Sakata. "Phase II trial of combined chemotherapy with irinotecan, S-1, and bevacizumab (IRIS/Bev) in patients with metastatic colorectal cancer (mCRC): Final analysis—Hokkaido Gastrointestinal Cancer Study Group (HGCSG) trial." Journal of Clinical Oncology 31, no. 4_suppl (February 1, 2013): 460. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.460.
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460 Background: The FIRIS study (Muro K et al. Lancet Oncol 2010;11:853–860) previously demonstrated the non-inferiority of Irinotecan plus S-1 (IRIS) to FOLFIRI for mCRC, with progression-free survival (PFS) as the primary endpoint. We previously reported that IRIS plus bevacizumab (IRIS/Bev) is very effective as first-line treatment (Komatsu Y et al. Acta Oncol. 2012 May 4). We now report the final results of this study. Methods: Eligible patients had to have mCRC with a confirmed diagnosis of adenocarcinoma, an age of >20 years, ECOG performance status (PS) of 0-1, and no history of prior chemotherapy. S-1 (40-60 mg depending on patients body surface area) was given orally, twice daily for 2 consecutive weeks, and 100 mg/m2irinotecan and 5 mg/kg bevacizumab was given intravenously on day 1 and 15, followed by 2-week rest period, within a 4-week cycle. The primary endpoint was safety. The secondary endpoints included overall response (OR), PFS, and overall survival (OS). Results: A total of 53 patients were enrolled from October 2007 through March 2009. The results were reported for 52 patients with evaluable lesions. The clinical characteristics of the patients were as follows. The median age was 63.5 years (range, 48 to 82). The male:female ratio was 3:2. The most common grade 3 or 4 adverse events were neutropenia (27%) and diarrhea (17%). Grade 3 or 4 hypertension (21%) was attributed to bevacizumab, but there were no life-threatening adverse events, such as gastrointestinal perforation. On an intention-to-treat basis, OR was 63.5% [95% confidence interval (CI) 50.4-76.5%], and the disease control rate was 94.2%. With a median follow-up time of 51.7 months, median PFS was 17.0 months (95%C.I. 14.2-19.8 months) and median survival time was 39.6 months (95%C.I. 34.2-45.0 months). Conclusions: IRIS/Bev is a remarkably active and generally well-tolerated first-line treatment for patients with mCRC. Randomized control trial comparing this regimen with oxaliplatin containing regimen(XELOX or mFOLFOX6 plus bevacizumab: TRICOLORE study) is already started. Clinical trial information: NCT00569790.
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Lippi, Ilaria, Francesca Perondi, Giulia Ghiselli, Sara Santini, Verena Habermaass, and Veronica Marchetti. "Anemia in Dogs with Acute Kidney Injury." Veterinary Sciences 11, no. 5 (May 13, 2024): 212. http://dx.doi.org/10.3390/vetsci11050212.
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Anemia is a well-known complication in CKD dogs, but its frequency in AKI dogs has been poorly investigated. The aim of the present study was to retrospectively evaluate frequency, degree of severity, and regeneration rate of anemia in relation to IRIS grade, etiology, therapy, and outcome. Medical records of dogs (2017–2023) with historical, laboratory, and ultrasound findings consistent with AKI were retrospectively reviewed. According to etiology, AKI was classified as ischemic/inflammatory (IS), infectious (INF), nephrotoxic (NEP), obstructive (OBS), and unknown (UK). AKI dogs were also classified according to therapeutical management (medical vs. hemodialysis), survival to discharge (survivors vs. non-survivors). Anemia was defined as HCT < 37% and classified as mild (HCT 30–37%), moderate (HCT 20–29%), severe (13–19%), or very severe (<13%). Anemia was classified as microcytic (MCV < 61 fL), normocytic (61 and 73 fL), and macrocytic (>73 fL). Anemia was considered hypochromic (MCHC< 32 g/dL), normochromic (32 and 38 g/dL), and hyperchromic (>38 g/dL). Regeneration rate was considered absent (RET ≤ 60,000/μL), mild 61,000–150,000/μL), and moderate (>150,000/μL). A total of 120 AKI dogs were included in the study, and anemia was found in 86/120 dogs (72%). The severity of anemia was mild in 32/86 dogs (37%), moderate in 40/86 dogs (47%), severe in 11/86 dogs (13%), and very severe in 3/86 (3%). Anemia was normochromic in 71/86 dogs (83%), hyperchromic in 12/86 dogs (14%), and hypochromic in 3/86 dogs (3%). Normocytic anemia was present in 56/86 dogs (65%), microcytic anemia in 27/86 dogs (31%), and macrocytic anemia in 3/86 dogs (4%). Non-regenerative anemia was found in 76/86 dogs (88%). The frequency of anemia increased significantly (p < 0.0001) with the progression of IRIS grade, although no significant difference in the severity of anemia was found among the IRIS grades. The frequency of non-regenerative forms of anemia was significantly higher than regenerative forms (p < 0.0001) in all IRIS grades. In our population of AKI dogs, anemia was a very frequent finding, in agreement with current findings in human nephrology.
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Takii, Yasumasa, Kouichi Hurukawa, Satoshi Maruyama, Toshiyuki Yamazaki, Jun Nishimura, Mikako Kawahara, Takemi Tomiyama, Kohei Akazawa, and Katsuyoshi Hatakeyama. "Phase II trial of irinotecan, S-1, and bevacizumab (IRIS/Bev) combination chemotherapy as second line for advanced colorectal cancer (NCCSG04)." Journal of Clinical Oncology 31, no. 4_suppl (February 1, 2013): 496. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.496.
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496 Background: The FIRIS study (Muro K et al. Lancet Oncol 2010;11:853-860) previously demonstrated the non-inferiority of Irinotecan plus S-1 (IRIS) to FOLFIRI for metastatic colorectal cancer (mCRC), with progression-free survival as the primary endpoint. IRIS plus bevacizumab (IRIS/Bev) was reported an active and generally well-tolerated first-line treatment for mCRC (Yuki et al. ASCO 2012 #3593). We planned a Phase II trial to evaluate the efficacy and safety of IRIS/Bev as second-line therapy for patients with mCRC. Methods: The study design was multicenter, single-arm, open-label phase II study. Eligible patients had to have mCRC with confirmed diagnosis of adenocarcinoma, history of oxaliplatin containing regimen as first-line therapy, an age from 20 to 80 years, ECOG performance status (PS) of 0-1. S-1 65 mg/m2 daily p.o. was given on days 1-14 and Irinotecan 75mg/m2 and Bevacizumab 10mg/kg i.v. were given on days 1 and 15 of a 28-day cycle. The primary endpoint was progression-free survival (PFS). The secondary endpoints included overall response rate (OR), overall survival (OS), time to treatment failure (TTF) and safety. Results: From 08/12 until 11/06, 35 patients were enrolled. One patient did not start therapy. Thirty-four patients were investigated. Median age was 63 years (range, 38 to 82). Twenty-five patients were male. The mean of relative dose intensity of TS-1/Irinotecan/Bev were respectively 92.1%/87.0%/86.2%. The OR was 21.1% (7/33) and disease control rate was 84.8% (28/33). Median PFS was 9.3 months, median TTF was 8.2 month and median survival time 23.1 month. On safety analysis, the incidence of grade 3 or 4 adverse reactions were as follows: neutropenia, 14.7%; fatigue, 14.7%; white blood cell decreased, 11.8%; anorexia, 8.8%; anemia, 8.8%; diarrhea, 2.9%; proteinuria, 5.9%; thromboembolic event, 2.9%. Conclusions: IRIS/Bev is an active and well-tollarated second-line treatment for patients with mCRC. Clinical trial information: UMIN000001631.
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Curtis, Paul D., Gwen B. Curtis, and William B. Miller. "Relative Resistance of Ornamental Flowering Bulbs to Feeding Damage by Voles." HortTechnology 19, no. 3 (January 2009): 499–503. http://dx.doi.org/10.21273/hortsci.19.3.499.
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Many plants have mechanisms of physical or chemical resistance that protect them from herbivores in their environment. Vertebrates such as meadow voles (Microtus pennsylvanicus) cause significant damage to ornamental plantings and home gardens. Our goal was to identify flowering bulbs that could be used to design more herbivore-resistant home landscapes. Single-choice feeding trials with captive prairie voles (Microtus ochrogaster) were used to assess the relative resistance of 30 bulb varieties to deter rodents from consuming fresh plant material and freeze-dried, powdered bulb mixed with a preferred food (applesauce). Each fresh bulb and dried-bulb/applesauce mix was offered twice to 12 to 15 pairs of adult prairie voles. Bulb varieties that resulted in the lowest mean consumption were assumed to be the most resistant to feeding activity. With fresh bulbs, only tulips (Tulipa spp.) exhibited no resistance to prairie vole feeding. Dried-bulb/applesauce mixes containing hyacinth (Hyacinth spp.), crocus (Crocus spp.), corn leaf iris (Iris bucharica), dutch and dwarf iris (Iris reticulata), onion (Allium spp.), and squill (Scilla siberica) were also readily consumed, and thus, these bulbs could be damaged at sites with high rodent activity. Daffodil (Narcissus spp.), painted arum (Arum italicum), camass (Camassia leichtlinii), glory-of-the-snow (Chinodoxa forbesii), autumn crocus (Colchicum spp.), crown imperial (Fritillaria imperialis), persian fritillaria (Fritillaria persica), snowdrop (Galanthus nivalis), and grape hyacinth (Muscari armeniacum) bulbs were resistant to prairie vole feeding in both forms (fresh bulbs and dried-bulb/applesauce mixes). Consequently, all of the specialty flower bulbs tested, except tulip, exhibited some resistance to prairie vole feeding in their fresh form, and could be suitable for designing herbivore-resistant landscapes.
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Curtis, Paul D., Gwen B. Curtis, and William B. Miller. "Relative Resistance of Ornamental Flowering Bulbs to Feeding Damage by Voles." HortTechnology 19, no. 3 (January 2009): 499–503. http://dx.doi.org/10.21273/horttech.19.3.499.
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Many plants have mechanisms of physical or chemical resistance that protect them from herbivores in their environment. Vertebrates such as meadow voles (Microtus pennsylvanicus) cause significant damage to ornamental plantings and home gardens. Our goal was to identify flowering bulbs that could be used to design more herbivore-resistant home landscapes. Single-choice feeding trials with captive prairie voles (Microtus ochrogaster) were used to assess the relative resistance of 30 bulb varieties to deter rodents from consuming fresh plant material and freeze-dried, powdered bulb mixed with a preferred food (applesauce). Each fresh bulb and dried-bulb/applesauce mix was offered twice to 12 to 15 pairs of adult prairie voles. Bulb varieties that resulted in the lowest mean consumption were assumed to be the most resistant to feeding activity. With fresh bulbs, only tulips (Tulipa spp.) exhibited no resistance to prairie vole feeding. Dried-bulb/applesauce mixes containing hyacinth (Hyacinth spp.), crocus (Crocus spp.), corn leaf iris (Iris bucharica), dutch and dwarf iris (Iris reticulata), onion (Allium spp.), and squill (Scilla siberica) were also readily consumed, and thus, these bulbs could be damaged at sites with high rodent activity. Daffodil (Narcissus spp.), painted arum (Arum italicum), camass (Camassia leichtlinii), glory-of-the-snow (Chinodoxa forbesii), autumn crocus (Colchicum spp.), crown imperial (Fritillaria imperialis), persian fritillaria (Fritillaria persica), snowdrop (Galanthus nivalis), and grape hyacinth (Muscari armeniacum) bulbs were resistant to prairie vole feeding in both forms (fresh bulbs and dried-bulb/applesauce mixes). Consequently, all of the specialty flower bulbs tested, except tulip, exhibited some resistance to prairie vole feeding in their fresh form, and could be suitable for designing herbivore-resistant landscapes.
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Siegel, David M. "Consultation with the Specialist." Pediatrics In Review 16, no. 12 (December 1, 1995): 477–78. http://dx.doi.org/10.1542/pir.16.12.477.
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Introduction Inflammation involving any part of the uveal tract (iris, ciliary body, and choroid) is described as uveitis. Adjacent ocular structures, including the retina, vitreous, and optic nerve, may be affected as well. The term uveitis is derived from the Latin uva, or "grape," due to the similarity in appearance between the bluish vein structure visible in a peeled blue grape and the middle vascular layer of the eye, the uvea. Within the broader term of uveitis are more specific designations, depending on the anatomic area involved. Thus, inflammation of the iris is called iritis, inflammation of the ciliary body is called cyclitis, and both occurring together is termed iridocyclitis. These latter structures, along with the anterior choroid, share a common blood supply and, if affected, tend to be inflamed together. Such inflammation can be referred to as anterior uveitis. Posterior uveitis describes inflammation of the posterior choroid (choroiditis), the retina (retinitis), or both (chorioretinitis). When the middle portion of the eye is involved (primarily retinal vessels and the peripheral portions of the retina and uveal tract), the condition is described as intermediate uveitis. This term has replaced other labels that appear in the literature, including chronic cyclitis, peripheral uveitis, and pars planitis.
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Nikicevic, N., S. Jovic, and A. Petrovic. "Possibilities of producing grape-based alcoholic drinks from newly created grapevine varieties." Journal of Agricultural Sciences, Belgrade 50, no. 2 (2005): 183–91. http://dx.doi.org/10.2298/jas0502183n.
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The paper is concerned with investigations on the possibility of producing grape-based alcoholic drinks from newly created grapevine varieties, such as Riesling Italian, Seedling 14660, Muscat Hamburg and Godominka. All chemical parameters for produced grape brandies, marc brandies and wine distillates complied with standards of quality as prescribed by the Regulations for quality of alcoholic drinks. Organoleptic evaluation proved that Seedling 14660 produced best scored wine distillate (17.85), Muscat Hamburg and Godominka gave best scored grape brandy (18.25) and Godominka yielded best scored marc brandy (18.40). Sensory properties of assessed brandies and wine distillate indicate that aroma and quality are gaining in intensity and level of improvement, starting from wine distillate to marc brandies. Also, intensive fruity-floral aroma reminding of lily-of-the-valley and iris fragrance is evident.
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Kyte, Richard. "Moral Reasoning as Perception: A Reading of Carol Gilligan." Hypatia 11, no. 3 (1996): 97–113. http://dx.doi.org/10.1111/j.1527-2001.1996.tb01017.x.
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Gilligan's understanding of moral reasoning as a kind of perception has its roots in the conception of moral experience espoused by Simone Weil and Iris Murdoch. A clear understanding of that conception, however, reveals grave difficulties with Gilligan's descriptions of the care perspective and justice perspective. In particular, we can see that the two perspectives are not mutually exclusive once we recognize that attention does not require attachment and that impartiality does not require detachment.
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Boustany, R., P. Pautier, A. Rey, S. Delaloge, A. Chompret, B. Bressac-De Paillerets, W. M. ElShamy, D. M. Livingston, J. Feunteun, and A. Spatz. "Overexpression of BRCA1-IRIS protein in familial ovarian cancers with no BRCA1 or BRCA2 germline mutation." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 5513. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.5513.
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5513 Background: Germline mutations of the BRCA1 and BRCA2 genes account for the majority of hereditary breast-ovarian carcinomas. Nevertheless, in some patients with family history of ovarian cancers, neither point mutations nor genomic alterations are identified. Recently, IRIS gene, an open reading frame that extended from codon 1 of BRCA1 to a termination point in intron 11, has been identified. The encoded protein has been reported to play a role in controlling the replication origins firing (ROF) pathway. The study presented here aims at characterizing whether ROF-related proteins are differentially expressed among familial ovarian cancers associated with a germline BRCA1 or 2 mutation, familial ovarian cancers with wild-type BRCA1/2 genes, and sporadic ovarian cancers. Methods: Tumor samples from 72 patients with ovarian cancer and screened for BRCA1 and BRCA2 mutation because of family history of breast/ovarian cancer were collected. These cases were matched with 134 sporadic ovarian cancers (controls) according to age, year of diagnosis, tumor stage, histological subtype, and grade. The cases distributed among 26 BRCA1-linked (BRCA1*) tumors, 9 BRCA2-linked (BRCA2*) tumors and 37 with no identified mutation (BRCA1wt/BRCA2wt). Tissue micro-arrays were prepared from the paraffin blocks. P53, MCM3, MCM4, Geminin, PTTG and BRCA1-IRIS immuno-expression were scored with no information on the sample group as follows: the final score was the product of the positive cells percentage by the staining intensity, the final result being used as a continuous variable. Differences between cases and controls were tested by a Wilcoxon test for paired samples. Results: IRIS expression was significantly higher in familial cancers than in controls (P=0.002). When BRCA1/2 genes status was taken into account, differences remained significant when BRCA1wt/BRCA2wt tumors (P=0.04), but not when BRCA1* tumors were compared with controls. However, the latter showed significant higher expression of Geminin than controls (P=0.04). Conclusions: BRCA-1 IRIS protein is overaccumulated in ovarian cancers developed by patients with family history. Our results suggest IRIS may play a role in the development of ovarian cancers and could be related with an ovarian susceptibility. No significant financial relationships to disclose.
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Bezhanova, Olga. "La mujer frente al capitalismo neoliberal en Feria de Ana Iris Simón (2020)." Journal of Gender and Sexuality Studies / Revista de Estudios de Género y Sexualidades 48, no. 2 (November 1, 2022): 113–28. http://dx.doi.org/10.14321/jgendsexustud.48.2.0113.
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Resumen La novela Feria de Ana Iris Simón cuestiona los tópicos de la cosmovisión neoliberal y propone una posibilidad de resistir los flujos del capital global que impactan a las mujeres de una manera particularmente grave. La novela ha provocado debates enconados en España, demostrando que la temática abordada por la escritora es sumamente vigente a principios del siglo XXI, cuando nos estamos dando cuenta de todas las dimensiones de la instauración definitiva del sistema neoliberal a escala global.
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Vasilyev, Vladimir A., and Anna S. Resnyanskaya. "Authentication of grape seed oil by isotopic analysis of carbon 13C/12C EA-IRMS." Processes and Food Production Equipment 17, no. 2 (2024): 10–18. http://dx.doi.org/10.17586/2310-1164-2024-17-2-10-18.
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Grape seed oil is a premium vegetable oil with high biological activity. The growing demand for the product and the expansion of the geography of supplies increase the risk of its falsification in terms of raw materials, method of production, and place of origin. The method of mass spectrometry of stable carbon isotopes (IRMS 13C/12C) is one of the most informative and often used to detect counterfeits of vegetable oils. The ratio of isotopes 13C/12C depends on the path of photosynthesis, generic and varietal composition, weather conditions, growing place. The indicator is defined for most vegetable oils, however, data on grape seed oil could not be found in the available literature. The article considers the possibility of using the EA-IRMS 13C/12C method for rapid detection of counterfeit oil. The ratio of 13C/12C isotopes for four commercially available grape oils was analyzed. The direct pressing grape oil provided by the Fanagoria ART was used as a control sample. The specimen is unquestionable in both the raw material and the region of origin. This product is obtained by direct pressing technology without the use of organic solvents. For this sample, a comparison was made between the isotopic carbon composition of the oil and the alcohol portion of the wine produced from the same batch of grapes. The study showed that the isotope ratio of 13C/12C for the reference sample was –27.87(± 0.10). For other images, the range of values ranged from –28.03 to –28.86. The difference between oil and wine averaged 0.870/00 (0.77–0.970/00). The isotopic ratios of 13C/12C do not change over time and depend on the place of origin, grape cultivation conditions, and the method of oil production. The EA-IRMS method together with other analysis methods can be used to identify the authenticity of grape seed oil, including its geographical origin.
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Komatsu, Y., S. Yuki, I. Iwanaga, M. Kudo, M. Tateyama, T. Amano, Y. Sakata, and M. Asaka. "Phase II clinical study of combination therapy with irinotecan and S-1(IRIS) for inoperable recurrent advanced colorectal cancer (2nd report): For Hokkaido Gastrointestinal Cancer Study Group (HGCSG)." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 4105. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4105.
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4105 Background: We planned to conduct a phase II clinical study of combination therapy with irinotecan and S-1, a new oral anticancer drug of the fluorinated pyrimidine type. We reported the interim reports of this study in colorectal cancer patients at ASCO 2006. Methods: The antitumor effect was the primary endpoint, while the safety, progression-free survival time, and median survival time were the secondary endpoints. The subjects were untreated patients with inoperable advanced colorectal cancer aged 20–75 years. Irinotecan was administered at a dose of 100 mg/m2 (on days 1 and 15) as an intravenous infusion over 90 minutes, and oral S-1 (40 mg/m2) was administered after breakfast and dinner and then withdrawn for 2 weeks. Results: Forty patients were enrolled in the present study. There were 23 men and 17 women. The median age was 62 years (range: 34 to 74 years). Two patients showed grade 4 neutropenia, but the next course could be given safely after dose reduction. Three patients had grade 3 diarrhea, but therapy could be continued with addition of an antidiarrhea drug. No other serious adverse reactions occurred (either hematological or non-hematological), and all patients could receive therapy safely on an outpatient basis. Forty pts. are evaluable for efficacy: RR was 52.5% (CR 1, PR 20, SD 17, PD 2, 95% CI, 37–68%) and Disease Control Rate (CR+PR+SD) was seen in 96.0% of pts. PFS of this regimen is 311 days. MST is not reached. Conclusions: IRIS therapy achieved a high response rate and could be given safely. These findings suggest that the therapy has potential as first-line treatment for inoperable advanced recurrent colorectal cancer. It seems that IRIS is a good treatment equal to FOLFIRI. Non-inferiority randomized phase III trial of IRIS vs. mFOLFOX6 (IFOX study) was planned, and it has been already started now. The latest data will be reported at the meeting. No significant financial relationships to disclose.
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Shock, Clinton C., Erik Feibert, Lynn Jensen, S. Krishna Mohan, and Lamont D. Saunders. "Onion Variety Response to Iris Yellow Spot Virus." HortTechnology 18, no. 3 (January 2008): 539–44. http://dx.doi.org/10.21273/horttech.18.3.539.
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Onion (Allium cepa) varieties for commercial production in eastern Oregon and southwestern Idaho are evaluated annually in replicated trials conducted at the Malheur Experiment Station, Oregon State University, near Ontario, Oregon. Characteristics evaluated include bulb yield, market grade, and the frequency of single centers. After the emergence of iris yellow spot virus (IYSV) as a threat to commercial onion production in the early 2000s, onion varieties at the Malheur Experiment Station have been evaluated for virus symptoms since 2004. Varieties showed differences in the severity of IYSV symptoms each year. Symptom severity increased over the years from 2004 to 2006, and variety virus ratings showed a strong negative correlation of severity with yield in 2005 and 2006. Marketable yield after 3 months of storage averaged 781, 534, and 551 cwt/acre in 2004, 2005, and 2006, respectively. Averaging over varieties, yield of bulbs larger than 4 inches in diameter was 438 cwt/acre, 56 cwt/acre, and 76 cwt/acre, and the average virus severity ratings were 1.1, 1.3, and 2.7 in 2004, 2005, and 2006, respectively. A few varieties showed a combination of high yield, large bulb size, low incidence of virus symptoms, and a predominance of single-centered bulbs. With the prevalence of IYSV, variety tolerance to IYSV has become an important production factor in the Treasure Valley.
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Chen, Wenbiao, Minglin Ou, Donge Tang, Yong Dai, and Weibo Du. "Identification and Validation of Immune-Related Gene Prognostic Signature for Hepatocellular Carcinoma." Journal of Immunology Research 2020 (March 7, 2020): 1–14. http://dx.doi.org/10.1155/2020/5494858.
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Immune-related genes (IRGs) have been identified as critical drivers of the initiation and progression of hepatocellular carcinoma (HCC). This study is aimed at constructing an IRG signature for HCC and validating its prognostic value in clinical application. The prognostic signature was developed by integrating multiple IRG expression data sets from TCGA and GEO databases. The IRGs were then combined with clinical features to validate the robustness of the prognostic signature through bioinformatics tools. A total of 1039 IRGs were identified in the 657 HCC samples. Subsequently, the IRGs were subjected to univariate Cox regression and LASSO Cox regression analyses in the training set to construct an IRG signature comprising nine immune-related gene pairs (IRGPs). Functional analyses revealed that the nine IRGPs were associated with tumor immune mechanisms, including cell proliferation, cell-mediated immunity, and tumorigenesis signal pathway. Concerning the overall survival rate, the IRGPs distinctly grouped the HCC samples into the high- and low-risk groups. Also, we found that the risk score based on nine IRGPs was related to clinical and pathologic factors and remained a valid independent prognostic signature after adjusting for tumor TNM, grade, and grade in multivariate Cox regression analyses. The prognostic value of the nine IRGPs was further validated by forest and nomogram plots, which revealed that it was superior to the tumor TNM, grade, and stage. Our findings suggest that the nine-IRGP signature can be effective in determining the disease outcomes of HCC patients.
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Paalosmaa, Tomi, and Miadreza Shafie-khah. "Feasibility of Innovative Smart Mobility Solutions: A Case Study for Vaasa." World Electric Vehicle Journal 12, no. 4 (October 14, 2021): 188. http://dx.doi.org/10.3390/wevj12040188.
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The global trend of urbanization and growing environmental awareness have risen concerns and demands to develop cities to become smarter. There is a grave need for ambitious sustainability strategies and projects, which can aid cities intelligently and comprehensively in this task. European Union (EU) launched 2014 the Horizon 2020 program (aka Horizon Europe), aiming to encourage the EU nations and their cities to take action to reach carbon neutrality through projects striving to smart city development. By promoting innovative, efficient, far-reaching, and replicable solutions, from the fields of smart energy production and consumption, traffic and mobility, digitalization and information communication technology, and citizen engagement, the objectives of the smart city strategies can be achieved. Horizon 2020 funded IRIS Smart Cities project was launched in 2017. One of the follower cities in the project has been the City of Vaasa in Finland. Vaasa’s climate objective is to reach carbon neutrality by 2030. In order to achieve this goal, the city has taken several decisive measures to enhance de-carbonization during recent years. One essential target for de-carbonization activities has been traffic and mobility. The primary purpose of the research conducted was to study the smart mobility, vehicle-to-grid (V2G), and second life battery solutions in the IRIS Smart Cities project, demonstrated first by the Lighthouse cities and then to be replicated in the City of Vaasa. The aim was to study which importance and prioritization these particular integrated solutions would receive in the City of Vaasa’s replication plan led by the City of Vaasa’s IRIS project task team of 12 experts, with the contribution of the key partners and stakeholders. Additionally, the aim was to study the potential of the integrated solutions in question to be eventually implemented in the Vaasa environment, and the benefit for the city’s ultimate strategy to reach carbon neutrality by 2030. The secondary object was to study the solutions’ compatibility with the IRIS lighthouse cities’ demonstrations and gathered joined experiences concerning the smart and sustainable mobility and vehicle-to-grid solutions, and utilization of 2nd life batteries. The results of the research indicated, that the innovative smart mobility solutions, including vehicle-to-grid and second life battery schemes, are highly relevant not only to the IRIS Lighthouse cities, but they also present good potential for the City of Vaasa in the long run, being compatible with the city’s climate and de-carbonization goals.
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Pfanner, Nasy Inthisone. "Teacher Corrective Oral Feedback in the Classroom." Journal of Language and Education 1, no. 2 (June 1, 2015): 46–55. http://dx.doi.org/10.17323/2411-7390-2015-1-2-46-55.
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The article reports on a study of teacher corrective oral feedback in Iris Becker Elementary School, a public school serving pupils from kindergarten-5th grade in Dearborn, Michigan. Some researchers claim that teacher corrective oral feedback is beneficial to L2 learning while others discard its merit. This study is an attempt to explore this topic further with young learners. The method used in the study included one classroom observation. The participants included one mainstream classroom teacher and about 25 students. The results show high teacher corrective oral feedback.
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Mizuno, Nobumasa, Kenji Yamao, Yoshito Komatsu, Masaki Munakata, Atsushi Ishiguro, Taketo Yamaguchi, Shinichi Ohkawa, et al. "Randomized phase II trial of S-1 versus S-1 plus irinotecan (IRIS) in patients with gemcitabine-refractory pancreatic cancer." Journal of Clinical Oncology 31, no. 4_suppl (February 1, 2013): 263. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.263.
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263 Background: Gemcitabine (Gem) monotherapy or Gem-based combination therapy is a standard first-line therapy for advanced pancreatic cancer (PC). There is no consensus on second-line therapy in patients (pts) with disease progression (PD) after Gem-based therapy. S-1, an oral fluoropyrimidine derivative, is commonly used for the second-line treatment of PC in Japan. Shitara et al previously reported that IRIS regimen showed that 44% of response rate (RR), 4.9 mo of median progression free survival (PFS), and 11.3 mo of median overall survival (OS), respectively. Therefore a randomized phase II trial was conducted to evaluate the efficacy and safety of IRIS compared with S-1 alone in the second-line setting. Methods: The inclusion criteria were as follows: (1) histologically or cytologically proven pancreatic adenocarcinoma or adenosquamous carcinoma; (2) confirmed PD after Gem treatment; (3) ECOG PS, 0-1; (4) measurable metastatic lesion based on RECIST criteria; (5) age ≥ 20 years; (6) total bilirubin < 2.0 mg/dL. Patients were randomized to receive either IRIS (CPT-11 100 mg/m2, iv, d1,15 plus S-1 80/100/120 mg/day based on BSA, po, d1-14, q4w; Arm A) or S-1 (80/100/120 mg/day based on BSA, po, d1-28, q6w; Arm B). The primary endpoint was to compare PFS in Arm A and Arm B. Results: Of a total of 137 pts enrolled between Nov 2008 and Mar 2011, 127 were eligible (60 randomized to Arm A and 67 to B). Median PFS in Arm A and B was 107 and 58 days, respectively (HR= 0.767; 95% CI, 0.527-1.114; p=0.1750). Median OS in Arm A and B was 208 and 176 days, respectively (HR=0.749; 95% CI, 0.512-1.093; p=0.1338). RR was 18.3% in Arm A (11/60; 95% CI, 9.5-30.4) and 6.0% in Arm B (4/67; 95% CI, 1.7-14.6)(p=0.0311). The incidences of grade 3/4 toxicities were as follows: neutropenia (15.6% and 4.3%), anorexia (23.4% and 17.3%), nausea (6.3% and 2.9%), and diarrhea (3.1% and 2.9%) in Arm A and B, respectively. Both regimens were tolerable. Conclusions: Although IRIS showed no significant improvement in PFS or OS compared with S-1 alone in this study, it showed significant advantage in RR, and favorable HR in both of PFS and OS. IRIS might have potential power to treat second-line PC patients. Further study is warranted. Clinical trial information: JapicCTI-080657.
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Kurysheva, N. I., O. Ye Rodionova, A. L. Pomerantsev, and G. A. Sharova. "Comparative study of the efficacy of lens extraction and laser peripheral iridotomy in primary anterior chamber angle closure." National Journal glaucoma 22, no. 4 (April 18, 2023): 3–14. http://dx.doi.org/10.53432/2078-4104-2023-22-4-3-14.
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PURPOSE. To compare the anatomical and functional effectiveness of lensectomy (LE) and laser peripheral iridotomy (LPI) in patients with primary anterior chamber angle closure.METHODS. This prospective study included 120 patients aged 41 to 80 years (60 eyes — primary angle closure (PAC), 30 — primary angle closure suspects (PACs), 30 eyes — without ophthalmic pathology). 30 PAC eyes were treated using LE with intraocular lens implantation, and 30 eyes with LPI. All subjects underwent swept source optical coherence tomography (SS-OCT). The following parameters were analyzed: spherical equivalent (SE), uncorrected and corrected distance visual acuity, intraocular pressure (IOP), Shaffer grade of angle opening, lens opacity, goniosyne chiae, choroidal thickness in the macular region, axial length (AL) of the eye, anterior chamber depth (ACD), lens vault (LV), iris curvature (ICurv), iris thickness at 750 µm from scleral spur (IT750), angle opening distance (AOD500, AOD750), iridotrabecular space area (TISA500, TISA750). Along with standard descriptive statistics methods, machine learning methods were used, including Data Driven Soft Independent Modelling of Class Analogies (DD-SIMCA).RESULTS. Every third eye with PAC had reached control group values after LE (DD-SIMCA specificity 0.67), which was not the case after LPI (DD-SIMCA specificity 1.0) with the probability of getting into the control group estimated as 0.01. After LE, all parameters of the anterior chamber angle did not significantly differ from the norm (p>0.05 for all), while ACD, ICurv even exceeded the norm (p=0.000). After LPI, there was a deepening of the ACD (from 2.34±0.28 mm to 2.36±0.280 mm, p=0.000) and a decrease in LV (from 0.864±0.120 µm to 0.843±0.110 µm, p=0.000), however, the result comparable to control was achieved only in ICurv (p=1.000). After LE in PAC, all parameters, including uncorrected visual acuity, SE, ACD, LV, iris profile, Shaffer grade of angle opening, and AOD500, AOD750, TISA500, TISA750 parameters in the superior and inferior sectors had advantages over those in PACs without treatment (p<0.05). After LPI, an improvement in a number of pa rameters was also achieved compared to LPI: ICurv, Shaffer grade of angle opening, AOD500, AOD750, TISA500, TISA750 in the superior sectors and AOD500 in the inferior sector (p><0.05).CONCLUSION. The effectiveness of LE in PAC is higher than LPI due to the better postoperative anterior chamber topography and lower IOP. Both treatments, especially LE, improve these parameters compared to PACs. Lens extraction is the treatment of choice at the early stages of primary angle closure.
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Yang, Meng, Changyu Zeng, Zhongcheng Gong, Bo Shao, Gaocheng Liu, Xuying Bao, and Bin Nie. "Development and validation of a predictive model for immune-related genes in patients with tongue squamous cell carcinoma." Open Life Sciences 17, no. 1 (January 1, 2022): 1657–68. http://dx.doi.org/10.1515/biol-2022-0469.
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Abstract The present study involved building a model of immune-related genes (IRGs) that can predict the survival outcomes of tongue squamous cell carcinoma (TSCC). Using the TCGA database, we collected the gene expression profiles of patients with TSCC and analyzed the differences in IRGs obtained from the ImmPort database. Subsequently, we constructed a predictive model. Transcription factors and differentially expressed IRGs can be used to construct TSCC regulatory network. CIBERSORT tool was used to analyze the relative proportion of 22 tumor-infiltrating immune cells in TSCC samples. Finally, a prognostic model is constructed. We established an IRG model formed by seven genes. The receiver operating characteristic value of the prognostic model based on IRGs is 0.739. After the analysis of the correlation between IRGs and clinical and pathological conditions, we found that Gast was related to grade, IRF9, LTB, and T stage. Among the 22 tumor-infiltrating immune cells, the resting natural killer (NK) cells were found to be related to the 5-year survival rate. This study constructed a prognostic model formed by seven IRGs and discussed the tumor-infiltrating immune cells, which are related to the survival outcome, reflecting the potential regulatory role of TSCC tumor immune microenvironment that could potentially promote individualized treatment.
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Mazko, Olesya Nikolayevna, Lyudmila Ivanovna Tikhomirova, Lyudmila Vladimirovna Shcherbakova, Natal'ya Grigor'yevna Bazarnova, and Dmitriy Alekseyevich Karpitsky. "FLAVONOIDS OF IRIS SIBIRICA L. GROWN IN VITRO CULTURE." chemistry of plant raw material, no. 3 (September 27, 2021): 301–8. http://dx.doi.org/10.14258/jcprm.2021039166.
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The aim of this study was to evaluate the effect of 6-benzylaminopurine (BAP) separately and in interaction with auxins on the change in the qualitative and quantitative composition of flavonoids in the raw materials of regenerating plants Iris sibirica L. Cambridge grade in comparison with aeroponic and intact raw materials using the method of high-performance liquid chromatography.
Raw materials of I. sibirica Cambridge variety obtained in vitro culture had a richer qualitative composition of flavonoids than intact plants. The dependence of the accumulation of flavonoids on the concentration of 6-benzylaminopurine in nutrient media was noted. The presence of 13 compounds was observed in extracts of 70% ethyl alcohol from regenerating plants grown at the lowest concentration of BAP (1.0 µM) within the experiment. In quantitative terms, the flavonoid apigenin was maximally determined on a medium with BAP 1 µM, and kaempferol - on media with BAP 5.0 µM, supplemented with auxins. For a medium with 7.5 µM BAP, the lowest variety of compounds was observed (9) and the lowest kaempferol content. Auxins influenced the synthesis of flavonoids. The amount of flavonoids in all variants of the experiment increased by an average of 13% in the presence of auxins.
The stages of the technological process of obtaining raw materials I. sibirica Cambridge variety on the basis of clonal micropropagation and cultivation in aeroponics conditions allowed to obtain raw materials that do not contain heavy and toxic metals, are not infected with pathogens and pests. With 1 m2 of useful area of aeroponics for 1 year, it is possible to collect 5 times more raw materials than with field cultivation. According to the qualitative composition of phenolic compounds, aeroponic raw materials are identical to intact plants.
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Vagle, Mark D., Colleen H. Clements, and Angela C. Coffee. "Analytic Productions in Post-Intentional Phenomenological Research." Cultural Studies ↔ Critical Methodologies 17, no. 6 (April 17, 2016): 427–41. http://dx.doi.org/10.1177/1532708616643983.
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In this article, we explore through a series of productions our analytic relationships with an interview with Iris—a fourth-grade student who participated in a post-intentional phenomenological study focusing on how social class–sensitive photo storying took shape in a high-poverty elementary school. Following Deleuze and Guattari’s configuration of assemblage as a constant process of making and unmaking, we have plugged into our assemblage (Jackson and Mazzei) some poetry and a dramatization, as well as some of the expected productions of academic writing such as theory, citations, and methodology. In this way, we reconceive the phenomenon as an assemblage that produces, rather than means.
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TUNEGARU, Magda Cristina. "INTERCULTURAL EDUCATION IN ROMANIA: A CONTENT ANALYSIS OF SOCIAL EDUCATION TEXTBOOKS FOR 6TH GRADE STUDENTS." Journal of Pedagogy - Revista de Pedagogie LXX, no. 2 (December 2022): 121–42. http://dx.doi.org/10.26755/revped/2022.2/121.
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In this paper, we aim to examine intercultural education textbooks, a subject that has been introduced in Romania, in the new school curriculum for middle school in 2017, for the 6th grade. The research uses content analysis to identify and analyze the cultural topics, the types of interactions that are suggested, and the extent to which these textbooks address social justice issues. We will approach both the textual and the visual elements of the textbooks. The data is analyzed on four levels, using a social justice perspective, mainly Iris Young’s conceptualization of oppression. First, we explore the micro level which refers to the characters’ attitudes and values; then the macro level which comprises historical and political factors. Further, we examine the international dimension comprised in the analyzed textbooks. Finally, we are interested in the authors’ position. For this purpose, we employ Hilliard’s (2014) conceptual frameworks, developed from Gray (2010) – to which we added 12 topics – and Risager (1991). Moreover, the research proposes further analysis and inquiries on the subject of intercultural education in Romania.
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Hafsa Bibi and Dr. Muhammad Ayaz. "حقوق المرأة التعليمي في عصر الحاضر فی ضوء السيرة النبويةﷺ." International Research Journal on Islamic Studies (IRJIS) 3, no. 02 (July 1, 2021): 1–17. http://dx.doi.org/10.54262/irjis.03.02.a01.
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Nowadays, Women are being imprisoned in the name of Islam. She is continuously being chained in the four walls of the house. Her basic teachings are being interpreted as sedition. Her fundamental rights are being trampled. On the other hand, in the name of women's emancipation, she is made or being made an ornament of the party and in the deception of liberalism, it is being turned into a flourishing pub. A vicious game of devilishness is being created. As a result, our Eastern values and traditions are crumbling to pieces, even though these two paths are of extremism and deviation. While the path of Islam and of the Prophet of Islam (peace and blessings of Allah be upon him) is the path between the two which is moderate, what is the path of moderation? Whose path will be entitled to victory in both worlds, so in this article, by the grace of God, you will find the full details of how the noble wives of the Holy Prophet (peace and blessings of Allah be upon him) and the wives of his companions performed the services of humanity and Islam. Moreover, this article will also explain how you chose the field of medicine and education? What are the achievements of the military in the field? What were their positions in the field of defense? This article will also highlight this topic. In short, the purpose will be to mention the deeds of the daughter of Hawa (Bint-e-Hawa) in all the important fields of life.
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Schaafsma, Evelien, Chongming Jiang, Thinh Nguyen, Kenneth Zhu, and Chao Cheng. "Microglia-Based Gene Expression Signature Highly Associated with Prognosis in Low-Grade Glioma." Cancers 14, no. 19 (September 30, 2022): 4802. http://dx.doi.org/10.3390/cancers14194802.
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Gliomas make up ~80% of malignant brain tumors in adults and are responsible for the majority of deaths from primary brain tumors. The glioma tumor microenvironment (TME) is a dynamic, heterogeneous mixture of extracellular matrix and malignant and non-malignant cells. Several ongoing clinical trials are evaluating the efficacy of therapies that target non-malignant cells, particularly immune cells. Consequently, a better understanding of the TME in glioma is pertinent. We utilized several gene expression datasets to evaluate the relationship between immune-related genes (IRGs) and patient prognosis. We generated microglia signatures using single-cell RNAseq data from human and mouse glioma cells to infer microglia abundance. Lastly, we built a LASSO Cox regression model that predicts patient survival. We found that 428 IRGs were negatively associated with survival in glioma patients. Overall survival was significantly lower in those with a high level of microglia infiltration. In addition, we also found that microglia abundance was significantly associated with several common genomic aberrations, including IDH2 and TP53 mutations. Furthermore, we found that patients with high risk scores had significantly worse overall survival than those with low risk scores in several independent datasets. Altogether, we characterized immune features predictive of overall survival in glioma and found that microglia abundance is negatively associated with survival. We developed a 23-gene risk score that can significantly stratify patients into low- and high-risk categories.
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Sukumar, Madhusudhanan, Andrea Wilke, Eva Jaeger, Josef Mautner, Joachim Ellwart, Hans-Jochem Kolb, Georg W. Bornkamm, and Armin Gerbitz. "Host Interferon gamma Production and STAT-1 Signalling Is Crucial for Minor Antigen Mediated Rejection of High Grade Lymphoma." Blood 110, no. 11 (November 16, 2007): 2175. http://dx.doi.org/10.1182/blood.v110.11.2175.2175.
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Abstract To date mechanisms of T-cell mediated immunity and immune-escape in high grade lymphomas are poorly understood. Using a transgenic mouse lymphoma model, where the proto-oncogene c-myc is driven in parts of the immunoglobulin lambda locus representing a t(8;22) translocation as found in Burkitt’s lymphoma, we developed a syngeneic model to investigate the anti-lymphoma activity of lymphoma specific T-cells. By retroviral transduction of a lymphoma specific antigen (chicken ovalbumin-IRES-GFP vector) into primary cell lines from c-myc transgenic lymphomas we established a model that would allow us to investigate the contribution of interferon gamma signalling in rejection of high grade lymphoma. All lymphomas established displayed low MHC class I and II levels on the surface when compared to wildtype B-cells. This expression could be enhanced by treatment with interferon gamma (100U/ml) up to 10 fold. When retrovirally transduced lymphoma cells were injected into wildtype or GFP transgenic C57BL/6 recipients, animals displayed a significant delay in lymphoma growth compared to IRES-GFP transduced control cell lines. 50% of the recipient mice rejected OVA containing lymphomas whereas we observed a 100% lymphoma growth of IRES-GFP transduced lymphomas in GFP transgenic recipients. Developing OVA containing lymphomas displayed a loss of GFP expression indicating a selection for non transduced cells. In spleens from mice successfully rejecting OVA-containing lymphomas we found up to 1.5% (±0.12%) SIINFEKL specific T-cells. To gain mechanistic insights of lymphoma rejection, we transferred OVA transduced lymphoma cells to Stat1−/− and IFNg−/− recipients. Lack of STAT1−/− on the recipient side or inability to secrete interferon gamma was associated with fast lymphoma progression and was not different when compared to IRES-GFP transduced cell lines injected into GFP transgenic hosts. Although we found 1.6% (±0.52%) SIINFEKL T cells in spleens of lymphoma bearing STAT1−/− animals, interferon gamma production was significantly decreased. We could also show that in wild type recipients, OVA containing lymphomas displayed high MHC class I and II expression which is completely absent in lymphomas from Stat1−/− recipients. Our results suggest that rejection of high grade lymphoma by a specific minor antigen is possible and Stat1 signaling and interferon gamma production by the host is crucial for lymphoma rejection.
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Euzébio, Diana Matos, Wesley Max Vieira dos Santos, Simonize Cunha Barreto de Mendonça, Cicera Eugênia Pereira da Silva, Licia Carvalho Ribeiro, Rosana Silva Amarante, Karina Madureira Ramalho, Matheus Guilherme Izidório de Souza, Danillo Barbosa da Conceição, and Angela Maria da Silva. "Perfil epidemiológico das infecções relacionadas à assistência à saúde em Unidade de Terapia Intensiva no período de 2019 a 2020." Research, Society and Development 10, no. 17 (December 25, 2021): e2101724926. http://dx.doi.org/10.33448/rsd-v10i17.24926.
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Introdução: Infecções relacionadas à assistência à saúde (IRAS) constituem um grave problema de saúde mundial, aumentando os custos de internação e das taxas de mortalidade. Desta forma, torna-se crescente a necessidade de acompanhamento e avaliação, da densidade de incidência e perfil epidemiológico das IRAS ocorridas na UTI do Hospital Universitário de Sergipe (HU-UFS). Objetivo: Avaliar se existe diferença significativa da incidência / prevalência de IRAS em pacientes internados na UTI, associado a fatores predisponentes. Metodologia: O estudo foi realizado por meio de pesquisa bibliográfica e levantamento de dados das fichas de vigilância epidemiológica realizada pelo Serviço de Controle de Infecção Hospitalar dos pacientes admitidos na Unidade de Terapia Intensiva (UTI) no período de 2019 a 2020. Estão incluídos os pacientes que atendam aos critérios de permanência mínima de 24 horas na unidade, e excluídos os que não atenderam este critério. Resultados: Houve maior densidade de IRAS no terceiro trimestre de 2020, com 26,44. Quanto aos dispositivos invasivos, observou-se maior taxa no uso de CVC, no quarto trimestre de 2020, com 83,9, entretanto não houve aumento de IRAS neste sítio. Foi observado maior frequência de pneumonia associada à ventilação (PAV), entre as topografias, correspondendo a 47,22% dos casos. Conclusão: As taxas encontradas neste estudo estão em consonância com os valores divulgados pela Anvisa, de outras instituições de mesmo perfil.
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Tian, Shu, Xu-Cheng Yin, Zhi-Bin Wang, Fang Zhou, and Hong-Wei Hao. "A VidEo-Based Intelligent Recognition and Decision System for the Phacoemulsification Cataract Surgery." Computational and Mathematical Methods in Medicine 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/202934.
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The phacoemulsification surgery is one of the most advanced surgeries to treat cataract. However, the conventional surgeries are always with low automatic level of operation and over reliance on the ability of surgeons. Alternatively, one imaginative scene is to use video processing and pattern recognition technologies to automatically detect the cataract grade and intelligently control the release of the ultrasonic energy while operating. Unlike cataract grading in the diagnosis system with static images, complicated background, unexpected noise, and varied information are always introduced in dynamic videos of the surgery. Here we develop a VidEo-Based Intelligent Recognitionand Decision (VEBIRD) system, which breaks new ground by providing a generic framework for automatically tracking the operation process and classifying the cataract grade in microscope videos of the phacoemulsification cataract surgery. VEBIRD comprises a robust eye (iris) detector with randomized Hough transform to precisely locate the eye in the noise background, an effective probe tracker with Tracking-Learning-Detection to thereafter track the operation probe in the dynamic process, and an intelligent decider with discriminative learning to finally recognize the cataract grade in the complicated video. Experiments with a variety of real microscope videos of phacoemulsification verify VEBIRD’s effectiveness.