Academic literature on the topic 'IRBIT forms'
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Journal articles on the topic "IRBIT forms"
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Angyal, Dora, Marcel J. C. Bijvelds, Marco J. Bruno, Maikel P. Peppelenbosch, and Hugo R. de Jonge. "Bicarbonate Transport in Cystic Fibrosis and Pancreatitis." Cells 11, no. 1 (December 24, 2021): 54. http://dx.doi.org/10.3390/cells11010054.
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CFTR, the cystic fibrosis (CF) gene-encoded epithelial anion channel, has a prominent role in driving chloride, bicarbonate and fluid secretion in the ductal cells of the exocrine pancreas. Whereas severe mutations in CFTR cause fibrosis of the pancreas in utero, CFTR mutants with residual function, or CFTR variants with a normal chloride but defective bicarbonate permeability (CFTRBD), are associated with an enhanced risk of pancreatitis. Recent studies indicate that CFTR function is not only compromised in genetic but also in selected patients with an acquired form of pancreatitis induced by alcohol, bile salts or smoking. In this review, we summarize recent insights into the mechanism and regulation of CFTR-mediated and modulated bicarbonate secretion in the pancreatic duct, including the role of the osmotic stress/chloride sensor WNK1 and the scaffolding protein IRBIT, and current knowledge about the role of CFTR in genetic and acquired forms of pancreatitis. Furthermore, we discuss the perspectives for CFTR modulator therapy in the treatment of exocrine pancreatic insufficiency and pancreatitis and introduce pancreatic organoids as a promising model system to study CFTR function in the human pancreas, its role in the pathology of pancreatitis and its sensitivity to CFTR modulators on a personalized basis.
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Mikoshiba, Katsuhiko. "The IP3 receptor/Ca2+ channel and its cellular function." Biochemical Society Symposia 74 (January 12, 2007): 9–22. http://dx.doi.org/10.1042/bss2007c02.
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The IP3R [IP3 (inositol 1,4,5-trisphosphate) receptor] is responsible for Ca2+ release from the ER (endoplasmic reticulum). We have been working extensively on the P400 protein, which is deficient in Purkinje-neuron-degenerating mutant mice. We have discovered that P400 is an IP3R and we have determined the primary sequence. Purified IP3R, when incorporated into a lipid bilayer, works as a Ca2+ release channel and overexpression of IP3R shows enhanced IP3 binding and channel activity. Addition of an antibody blocks Ca2+ oscillations indicating that IP3R1 works as a Ca2+ oscillator. Studies on the role of IP3R during development show that IP3R is involved in fertilization and is essential for determination of dorso-ventral axis formation. We found that IP3R is involved in neuronal plasticity. A double homozygous mutant of IP3R2 (IP3R type 2) and IP3R3 (IP3R type 3) shows a deficit of saliva secretion and gastric juice secretion suggesting that IP3Rs are essential for exocrine secretion. IP3R has various unique properties: cryo-EM (electron microscopy) studies show that IP3R contains multiple cavities; IP3R allosterically and dynamically changes its form reversibly (square form–windmill form); IP3R is functional even though it is fragmented by proteases into several pieces; the ER forms a meshwork but also forms vesicular ER and moves along microtubules using a kinesin motor; X ray analysis of the crystal structure of the IP3 binding core consists of an N-terminal β-trefoil domain and a C-terminal α-helical domain. We have discovered ERp44 as a redox sensor in the ER which binds to the luminal part of IP3R1 and regulates its activity. We have also found the role of IP3 is not only to release Ca2+ but also to release IRBIT which binds to the IP3 binding core of IP3R.
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Al-Deaibes, Mutasim. "The syntax-phonology mapping of reduplicative forms in the Jordanian Arabic dialect of Irbid." Ampersand 8 (2021): 100077. http://dx.doi.org/10.1016/j.amper.2021.100077.
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Pellet, Rémi, and Khadidja Bhaloul. "Les rachats massifs par la BCE de titres publics sont une forme de monétisation des dettes publiques." Gestion & Finances Publiques, no. 4 (July 2020): 43–47. http://dx.doi.org/10.3166/gfp.2020.4.009.
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Du point de vue du juriste, les rachats massifs de titres publics par le Système européen de banques centrales sont une forme de « monétisation des dettes publiques », qui a des effets quasi-équivalents à ceux qui découleraient d’achats sur le marché primaire, ce que prohibe expressément le traité de Maastricht, comme vient de le rappeler la Bundesbank. Il en irait de même des monnaies « hélicoptère » ou « fiscale » ou de l’annulation totale ou partielle des dettes rachetées.
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Bzour, Ansam, and Istvan Valanszki. "A study of developing a spatial entity greenway in the case of Irbid City – Jordan." Landscape architecture and art 18 (October 7, 2021): 104–12. http://dx.doi.org/10.22616/j.landarchart.2021.18.11.
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Greenways are urban elements that are designed to show the linear consistency and connectivity between open green spaces and cause a development in the urban texture. As a city starts to grow, the absolute metropolitan development should be followed by an ongoing protection of the rural and urban territories. The nexus between the city development and the fortification of the open agricultural and rural lands is deemed a good strategy in order to result in a homogenous urban fabric of the city. The study aims to present a greenway model of development to work as a prototype applied on an existing route in Irbid City-Jordan by using the methods of testing and analyzing the route during the site visit and by using GIS base maps in order to come up with an absolute combination between monitoring the city growth, maintaining the quality of the agricultural lands and serving the public and local needs in order to result in a more balanced and controlled growth of the city. Irbid city is located in the northern part of Jordan with a radial urban expansion model of growth extending from the historical center and spreading toward the outskirts of the city. Regarding the significant increase in the number of population in Irbid City-Jordan since the 1970s until nowadays and the continuous need for habitats, there was a huge number of housing projects in the inner part of the city that expanded toward the outer part including the rural areas, resulting in a huge lack of agricultural lands and open recreational spaces where people can benefit from. Those spaces form an outlet of the city connected with the inner part by a route. Establishing a greenway along the route raises the integration between people and their lands and encourages farmers to develop and harvest. According to this study, the greenway development, which forms a breath out to the highly built-up area in the city, has become a great tool to result in tremendous beneficial outcomes to the city development.
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Baryshev, Ruslan, Olga Babina, Tatiana Sergienko, and Pavel Zakharov. "New approaches toward statistical form design in user services." Scientific and Technical Libraries, no. 2 (February 1, 2018): 16–25. http://dx.doi.org/10.33186/1027-3689-2018-2-16-25.
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The Siberian Federal University Scientific Library is characterized as one of the key players in the university’s education and research support. Approaches toward IRBIS-based design of statistical forms are examined. The method enables to take due account of remote users data and the features of the Siberian Federal University Scientific Library’s hybrid collection. Several key statistical indicators to characterize Library’s performance within the user services cycle are discussed. The set of statistical factors used by the University administration and librarians to analyze the Library’s performance are revealed. The authors conclude that the statistical indicators have to be improved to reflect changes in the collection structure, new promising sources and new user needs and demands which will also contribute to developing new approaches in library and information services. They emphasize that the library statistical data are of valuable source for the sphere of culture as a whole, as it enables to compare organizations’ performance, to reveal newest trends, and to measure their potentiality.
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Dianova, Yuliya Viktorovna, and Sergei Aleksandrovich Dianov. "Funfair past and present for geocultural branding of Ural cities." Человек и культура, no. 3 (March 2020): 60–72. http://dx.doi.org/10.25136/2409-8744.2020.3.32836.
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The subject of this research is the funfair past and present for geocultural branding of Ural cities. The object is the geocultural potential of small historical Ural cities – Irbit and Krasnoufimsk. In the course of study it was established that in modern urban space there are noticeable creative initiatives that demonstrate an alternative vision of image of the city and its local communities (production, consumer, artistic). It is underlined that geocultural resources of the city is a fusion of particular natural-landscape and sociocultural resources that permanently “provoke” arrangement of a situation for a creative action – determination of latent capabilities of these resources and their subsequent utilization for the purpose of testing new promising suggestions, are useful for artistic self-expression, as well as mending an effective strategy for geocultural branding of the city. Solution of the indicated problems leans on the concept of geocultural branding of the city and territories in the forma that it was described in scientific writings of D. N. Zamyatin, as well as on the theory of creative city of C. Landry, namely the thesis on creative action. The scientific novelty consists in demonstration of potential application of the concept of geocultural branding to a funfair action. Shifting away from the traditional understanding of designation of funfair, its recognition as the generator of “creative energy” of the city, the center of cultural and artistic activity of the people, allows finding consensual solutions between the local authorities, business communities and creative groups.
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Al-Qarqaz, Firas, Khaldon Bodoor, Awad Al-Tarawneh, Haytham Eloqayli, Wisam Al Gargaz, Diala Alshiyab, Jihan Muhaidat, Mohammad Alqudah, Rowida Almomani, and Maha Marji. "Basal Cell Carcinoma Pathology Requests and Reports Are Lacking Important Information." Journal of Skin Cancer 2019 (January 3, 2019): 1–5. http://dx.doi.org/10.1155/2019/4876309.
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Introduction.Basal cell carcinoma (BCC) is the most common cancer affecting humans. Luckily it has negligible risk for metastasis; however it can be locally destructive to surrounding tissue. The diagnosis of this tumor relies on clinical and dermoscopic features; however confirmation requires biopsy and histologic examination. Based on clinical and pathologic findings, BCC is classified as low or high risk subtype. The clinician requesting pathology examination for BCC should provide the pathologist with detailed information including patient details, relevant clinical and medical history, site and type of the biopsy, and whether this is a primary or recurrent lesion. The pathologist on the other hand should write an adequate report containing a minimum of core set of parameters including type of BCC, depth of invasion, presence of lymphovascular or perineural invasion, and the excision margins.Objectives.The objective of this study is to evaluate whether requests by clinicians and pathology reports of BCC are adequate.Methods.This is a retrospective analysis done at the dermatology department, faculty of medicine at Jordan University of Science and Technology, Irbid, Jordan. Reports for the period from January 2003 to December 2017 were retrieved and analyzed for data completeness.Results.Most clinical request forms of BCC provided by clinicians are inadequate and lack important relevant information especially in regard to lesion history, patient medical history, and whether BCC is a primary or a recurrent one. Pathology reports for BCC cases also have significant deficiency especially in describing the histologic subtype, depth of invasion, and presence of lymphovascular and perineural invasion. However, the tumor excision margins are adequately described in almost all reports.Conclusions.The study shows that clinicians do not provide adequate clinical information when submitting a request for histopathologic examination of BCC. Similarly, pathologists write incomplete reports that lack important pathologic features. Having pre-set forms (electronic proforma) can help overcome missing information.
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Ayyoub, Samia Ayyoub Salim, and Nuha Mahmoud Mesleh Radaydeh. "The Knowledge of People About the Use of Renewable Energy and Environmental Awareness in Their Area, Irbid Governorate as a Case Study." International Journal of Sustainable Development and Planning 16, no. 2 (April 23, 2021): 365–71. http://dx.doi.org/10.18280/ijsdp.160216.
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In the global effort to curb energy consumption and promote a sustainable lifestyle for our societies, we must strive to lower our energy needs in all aspects of our lives. One of the biggest contributors to our energy requirements are the buildings we spend most of our time inside. Buildings’ energy consumption can take many forms, such as, air conditioning, heating, ventilation, and lighting systems in order to create a comfortable environment for the users. One way of reducing buildings’ energy consumption is the use of renewable resource for energy. The main aim of this research is to measure and assess the public perceptions, knowledge and awareness of the concept of renewable energy, with specific regards to the use of solar photovoltaic cells, as well as investigate the desire to spend on the installation of renewable energy sources. Data was collected through a survey questionnaire applied in Irbid governorate in the north of Jordan. The statistical SPSS program was used to analyze closed-ended questionnaires and obtain numerical results based on arithmetical averages and percentages. The results show people are adequately aware of the benefits of renewable energy and most would like to have photovoltaic cells installed. However, 54.35% of the study sample live in apartments and do not have the space for the installation. 70.1% are open to the idea of sharing the solar energy system with their neighbors. 50% thought that the photovoltaic cells affected the aesthetics of the architecture style of the buildings especially the more traditional styles. It is concluded that the government needs to build a large-scale solar energy project to sustainably produce electricity instead of relying on individuals who generally lack the ability or the space for such systems, taking in note that the general public supports such concepts.
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Kodolov, S. D., A. S. Klimova, A. Yu Filimonov, and E. K. Aksyonova. "Deployment of Software-Controlled Distributed Laboratory Complex for a Higher Educational Institution." Journal of Physics: Conference Series 2134, no. 1 (December 1, 2021): 012017. http://dx.doi.org/10.1088/1742-6596/2134/1/012017.
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Abstract The intensive development of information systems and communication infrastructures has led to the emergence of new approaches and new tools for their management. Cloud services, virtualization technologies and software-based management tools are actively used today for building modern information systems which provides additional opportunities for managing components of these systems and for expanding such systems abilities. The use of such approaches and tools can provide a solution to the complex of problems faced by education institutions today, presenting new methods of distance learning and new forms of practical training. The balanced use of virtualization technologies and software-based control tools allows building distributed laboratory complexes of a new generation which will provide new possibilities for using the equipment that is available in educational institutions. The use of such complexes in the educational process allows not only to instill in students the skills of managing the confgura-tions of communication infrastructures that are especially relevant today, but also to organize, in addition to traditional laboratory work, new forms of contactless practical classes. When conducting such classes, students get the opportunity to fully-functional remote access to the virtual and physical components of the complex, which is especially important for organizing the educational process in modern conditions associated with the COVID-19 pandemic.The article discusses modern approaches to the construction of software-controlled communication infrastructures, tools for software-based management of their components and also, an example of the implementation of these approaches and such tools usage in the construction of a distributed laboratory complex for a higher educational institution. The main advantages of the approach based on the use of hypervisors and emulators are presented, the experience of its deployment in the modernization of the laboratory complex for a IRIT-RTF UrFU is considered.
Book chapters on the topic "IRBIT forms"
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Ibrahim, Anwar, and Hikmat Ali. "Integrating Sustainability and Renewable Energy Systems with Architecture Form and Urban Design: Greening the Central District of Irbid, Jordan." In Renewable Energy and Sustainable Buildings, 609–21. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-18488-9_48.
Full textConference papers on the topic "IRBIT forms"
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Zima, D. E., and A. V. Kochegura. "Prospects for soybean selection for an increased percentage of protein in seeds." In CURRENT STATE, PROBLEMS AND PROSPECTS OF THE DEVELOPMENT OF AGRARIAN SCIENCE. Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea”, 2020. http://dx.doi.org/10.33952/2542-0720-2020-5-9-10-60.
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The article presents the results of a three-year evaluation of soybean varieties, breeding lines, as well as collection varieties of diverse origin cultivated in production and preliminary variety testing plots. The maximum protein content in the seeds of varieties approved for cultivation was 41.4 % with an average value of 39.9 %. A significantly higher range of trait variability (9.9 %) was found in the soybean collection. Promising initial forms for breeding are variety specimens ‘Zelda’, ‘Irbis’, ‘Sforza’, ‘Santana’ and ‘Vesta’. They accumulate 44.3 % to 46.7 % of protein in seeds.