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Journal articles on the topic 'IPRE'

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Author: Grafiati

Published: 10 March 2023

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1

Hussein, Abdelaziz M., Nashwa Barakat, Amira Awadalla, Mahmoud M. Gabr, Sherry Khater, Ahmed M. Harraz, and Ahmed A. Shokeir. "Modulation of renal ischemia/reperfusion in rats by a combination of ischemic preconditioning and adipose-derived mesenchymal stem cells (ADMSCs)." Canadian Journal of Physiology and Pharmacology 94, no. 9 (September 2016): 936–46. http://dx.doi.org/10.1139/cjpp-2016-0018.

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The present study investigated the effects of combination of ischemic preconditioning (Ipre) and adipose-derived mesenchymal stem cells (ADMSCs) on renal ischemia–reperfusion (I–R) injury in rats. 90 male Sprague Dawley rats were divided into 5 equal groups; sham operated, control (45 min left renal ischemia), Ipre group as control group with 3 cycles of Ipre just before renal ischemia, ADMSCs-treated group (as control with ADMSCs 106 cells in 0.1 mL via penile vein 60 min before ischemia time), and Ipre + ADMSCs group as ADMCs group with 3 cycles of Ipre. Ipre and ADMSCs groups showed significant decrease in serum creatinine and blood urea nitrogen (BUN) and caspase-3 and CD45 expression in kidney and significant increase in HIF-1α, SDF-1α, CD31, and Ki67 expressions in kidney compared with the control group (p < 0.05). Moreover, the Ipre + ADMSCs group showed significant decrease in serum BUN and caspase-3 and CD45 expression in kidney with significant increase in HIF-1α, SDF-1α, CD31, and Ki67 expression in kidney compared with the Ipre and ADMCs groups (p < 0.05). We concluded that Ipre potentiates the renoprotective effect of ADMSCs against renal I/R injury probably by upregulation of HIF-1α, SDF-1α, CD31, and Ki67 and downregulation of caspase-3 and CD45.

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2

Szabó, Márton R., Renáta Gáspár, Márton Pipicz, Nóra Zsindely, Petra Diószegi, Márta Sárközy, László Bodai, and Tamás Csont. "Hypercholesterolemia Interferes with Induction of miR-125b-1-3p in Preconditioned Hearts." International Journal of Molecular Sciences 21, no. 11 (May 26, 2020): 3744. http://dx.doi.org/10.3390/ijms21113744.

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Ischemic preconditioning (IPre) reduces ischemia/reperfusion (I/R) injury in the heart. The non-coding microRNA miR-125b-1-3p has been demonstrated to play a role in the mechanism of IPre. Hypercholesterolemia is known to attenuate the cardioprotective effect of preconditioning; nevertheless, the exact underlying mechanisms are not clear. Here we investigated, whether hypercholesterolemia influences the induction of miR-125b-1-3p by IPre. Male Wistar rats were fed with a rodent chow supplemented with 2% cholesterol and 0.25% sodium-cholate hydrate for 8 weeks to induce high blood cholesterol levels. The hearts of normo- and hypercholesterolemic animals were then isolated and perfused according to Langendorff, and were subjected to 35 min global ischemia and 120 min reperfusion with or without IPre (3 × 5 min I/R cycles applied before index ischemia). IPre significantly reduced infarct size in the hearts of normocholesterolemic rats; however, IPre was ineffective in the hearts of hypercholesterolemic animals. Similarly, miR-125b-1-3p was upregulated by IPre in hearts of normocholesterolemic rats, while in the hearts of hypercholesterolemic animals IPre failed to increase miR-125b-1-3p significantly. Phosphorylation of cardiac Akt, ERK, and STAT3 was not significantly different in any of the groups at the end of reperfusion. Based on these results we propose here that hypercholesterolemia attenuates the upregulation of miR-125b-1-3p by IPre, which seems to be associated with the loss of cardioprotection.

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3

Tawfik, Mona, Samy Makary, and Mohammed Keshawy. "Upregulation of antioxidant nuclear factor erythroid 2-related factor 2 and its dependent genes associated with enhancing renal ischemic preconditioning renoprotection using levosimendan and cilostazol in an ischemia/reperfusion rat model." Archives of Medical Science 18, no. 2 (January 28, 2021): 1–34. http://dx.doi.org/10.5114/aoms/111373.

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IntroductionIschemic preconditioning (Ipre) provides protection against renal ischemia-reperfusion (I/R) injury with its associated remote organ damage. This study examined the enhancing protective effect of Ipre with levosimendan or cilostazol in I/R-induced kidney and lung injury in a rat model.Material and methodsRats were divided into: sham-operated, I/R control, Ipre control, I/R + cilostazol or levosimendan and Ipre + cilostazol or levosimendan. Drugs were given 30 min before left renal I/R or 4 cycles of Ipre just before renal ischemia.ResultsThe Ipre combined with the implemented drugs enhanced physiological antioxidant defense genes including renal nuclear factor erythroid 2-related factor 2 (Nrf2) and its dependent genes heme oxygenase-1 (HO-1) and NADPH-quinone oxidoreductase-1 (NQO-1) and improved malondialdehyde and superoxide dismutase renal tissue levels. The combined effect improved I/R consequences for blood urea, creatinine, and creatinine clearance and improved blood oxygenation and metabolic acidosis. Moreover, the combination improved the renal soluble intercellular adhesion molecule (ICAM), tumor necrosis factor α (TNF-α) and interlukin-6 (IL-6) with histopathological improvement of tubular necrosis with a decrease in the apoptotic marker caspase-3 and an increase in the anti-apoptotic Bcl-2 expression.ConclusionsCilostazol or levosimendan potentiates the renoprotective effect of Ipre against renal I/R injury, associated with upregulation of antioxidant genes Nrf2, HO-1, and NOQ-1 expression.

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4

Saini, Ashish, Jingyu Hou, and Wanlei Zhou. "Breast Cancer Prognosis Risk Estimation Using Integrated Gene Expression and Clinical Data." BioMed Research International 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/459203.

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Background. Novel prognostic markers are needed so newly diagnosed breast cancer patients do not undergo any unnecessary therapy. Various microarray gene expression datasets based studies have generated gene signatures to predict the prognosis outcomes, while ignoring the large amount of information contained in established clinical markers. Nevertheless, small sample sizes in individual microarray datasets remain a bottleneck in generating robust gene signatures that show limited predictive power. The aim of this study is to achieve high classification accuracy for the good prognosis group and then achieve high classification accuracy for the poor prognosis group.Methods. We propose a novel algorithm called the IPRE (integrated prognosis risk estimation) algorithm. We used integrated microarray datasets from multiple studies to increase the sample sizes (∼2,700 samples). The IPRE algorithm consists of a virtual chromosome for the extraction of the prognostic gene signature that has 79 genes, and a multivariate logistic regression model that incorporates clinical data along with expression data to generate the risk score formula that accurately categorizes breast cancer patients into two prognosis groups.Results. The evaluation on two testing datasets showed that the IPRE algorithm achieved high classification accuracies of 82% and 87%, which was far greater than any existing algorithms.

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5

Faletrov, Y. V., K. A. Gilep, A. S. Falchevskaya, M. S. Horetski, J. V. Panada, E. V. Andrievskaya, E. V. Rudaya, et al. "In silico modeling of izoniazid-steroid conjugates interactions with cytochromes P450 of mycobacteria and their bioconversion in vitro by the cells." Biomeditsinskaya Khimiya 66, no. 5 (2020): 378–85. http://dx.doi.org/10.18097/pbmc20206605378.

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Molecular docking of four hydrazones of isoniazid with steroids (dehydroepiandrosterone, pregnenolone, 16α,17α-epoxypregnenolone, cholestenone) — IDHEA, IPRE, IEP5, ICHN, to mycobacterial cytochromes P450 was performed. The in silico study has shown than these hydrazones can be effectively bound to CYP121, CYP124, CYP125, CYP126A1, CYP130, and CYP51 with binding energy ranged from -9 kcal/mol to -12 kcal/mol. Calculations also demonstrated enhancement of passive lipid bilayer permeability with respect to isoniazid. In vitro IDHEA, IPRE, IEPR were found to undergo bioconversion into their 3-keto-4-en derivatives. This suggests their ability to penetrate into M. tuberculosis H37Rv cells. The results of this study are important in the context of understanding of specificity of binding of synthetic steroid derivatives to mycobacterial CYPs and indicate the possibility of using the steroid compounds studied by us as new ligands for these enzymes.

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6

Anam, Khoirul, and Dewi Rakhmawati. "Pengaruh Penyuluhan terhadap Pengetahuan Kesehatan Reproduksi Remaja." Jurnal MID-Z (Midwivery Zigot) Jurnal Ilmiah Kebidanan 5, no. 1 (May 31, 2022): 99–107. http://dx.doi.org/10.56013/jurnalmidz.v5i1.1594.

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iKnowledge iof ireproductive ihealth iis iindispensable ifor iadolescents ientering ipubertyi. iThis istudy iaims ito idetermine ithe ieffect iof iadolescent ireproductive ihealth icounselling ion ithe ilevel iof iexpertise iin ifacing ipuberty iin ifemale istudents iat iIslamic iSchool iMiftahul iUlum iSilo iJember. iPre-iexperimental iresearch idesign iwith ione igroup iprei-itest iand iposti-itest idesign. iThe ipopulation iof iall iclass iVII istudents iis i29i, iwith inoni-iprobability isampling itechniquesi—idata ianalysis iwith iWilcoxon istatistical itesti. iBased ion ithe iresults iof ithe iWilcoxon itesti, ia ivalue iof < α (0.000<0.05) iwas iobtainedi. iThe ilevel iof iknowledge ibefore icounselling i (pre-test) iis ialmost ientirely (93.1%) iinsufficient iknowledge, iand iafter ibeing igiven icounselling i (post-test),imost (55.2%) ihave ia igood iunderstanding. iThe iresults iof ithis istudy ican ibe iconcluded ithat iadolescent ireproductive ihealth icounselling iinfluences ithe ilevel iof iknowledge iin ifacing ipuberty. iIt iis ihoped ithat ithe irespondents iof ithis istudy ican ihelp iincrease ithe iunderstanding iof ifemale istudents ifacing ipuberty.

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7

Kurzenev, V. A., V. T. Perekrest, and I. V. Perekrest. "Balance Technologies for Calculating and Predictive Estimation of Labor Resources for Regional Socio-Economic Systems." Administrative Consulting, no. 4 (May 23, 2022): 35–43. http://dx.doi.org/10.22394/1726-1139-2022-4-35-43.

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The article analyzes the institutional and technological features of the calculus (representation) and predictive assessment of the balance of labor resources for regional economic systems.The review is carried out in the general context of the particular tasks of developing egional strategies: goal-setting, analysis and forecasting.The theoretical and practical experience of the laboratory of mathematical methods of data analysis of IPRE RAS and St. Petersburg EMI RAS (until 2018) in the framework of the direction “Economic and mathematical methods for state regulation of socially oriented economies at the regional level within the framework of innovative development models” is presented.

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Deviany, Poppy E., Philip W. Setel, Henry D. Kalter, Trisari Anggondowati, Martini Martini, Fitri Nandiaty, Kamaluddin Latief, et al. "Neonatal mortality in two districts in Indonesia: Findings from Neonatal Verbal and Social Autopsy (VASA)." PLOS ONE 17, no. 3 (March 14, 2022): e0265032. http://dx.doi.org/10.1371/journal.pone.0265032.

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Background The Government of Indonesia is determined to follow global commitments to reduce the neonatal mortality rate. Yet, there is a paucity of information on contributing factors and causes of neonatal deaths, particularly at the sub-national level. This study describes care-seeking during neonates’ fatal illnesses and their causes of death. Methods We conducted a cross-sectional community-based study to identify all neonatal deaths in Serang and Jember Districts, Indonesia. Follow-up interviews were conducted with the families of deceased neonates using an adapted verbal and social autopsy instrument. Cause of death was determined using the InSilicoVA algorithm. Results The main causes of death of 259 neonates were prematurity (44%) and intrapartum-related events (IPRE)-mainly birth asphyxia (39%). About 83% and 74% of the 259 neonates were born and died at a health facility, respectively; 79% died within the first week after birth. Of 70 neonates whose fatal illness began at home, 59 (84%) sought care during the fatal illness. Forty-eight of those 59 neonates went to a formal care provider; 36 of those 48 neonates (75%) were moderately or severely ill when the family decided to seek care. One hundred fifteen of 189 neonates (61%) whose fatal illnesses began at health facilities were born at a hospital. Among those 115, only 24 (21%) left the hospital alive–of whom 16 (67%) were referred by the hospital. Conclusions The high proportion of deaths due to prematurity and IPRE suggests the need for improved management of small and asphyxiated newborns. The moderate to severe condition of neonates at the time when care was sought from home highlights the importance of early illness recognition and appropriate management for sick neonates. Among deceased neonates whose fatal illness began at their delivery hospital, the high proportion of referrals may indicate issues with hospital capability, capacity, and/or cost.

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9

Lai, Ting Yi, Jing-Dong Guo, James C. Fettinger, Shigeru Nagase, and Philip P. Power. "Facile insertion of ethylene into a group 14 element-carbon bond: effects of the HOMO–LUMO energy gap on reactivity." Chemical Communications 55, no. 3 (2019): 405–7. http://dx.doi.org/10.1039/c8cc08488b.

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The diarylstannylenes, Sn(Ar^iPr4)₂ and Sn(Ar^iPr6)₂, (Ar^iPr4 = C₆H₃-2,6-(C₆H₃-2,6-ⁱPr₂)₂, Ar^iPr6 = C₆H₃-2,6-(C₆H₂-2,4,6-ⁱPr₃)₂), undergo a facile migratory insertion reaction with ethylene at 60 °C to afford the alkyl aryl stannylenes Ar^iPr4SnCH₂CH₂Ar^iPr4 and Ar^iPr6SnCH₂CH₂Ar^iPr6 which were characterized via¹H, ¹³C and ¹¹⁹Sn NMR, UV-vis and IR spectroscopy, as well as by X-ray crystallography.

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10

Siti Nabilah and Resi Galaupa. "The Effect of Acupressure Therapy on Menstrual Pain Intensity." East Asian Journal of Multidisciplinary Research 1, no. 5 (June 28, 2022): 853–58. http://dx.doi.org/10.55927/eajmr.v1i5.597.

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Reproductive health of young women is not only a sexual problem but also involves all aspects of reproduction, including secondary sex development, which includes soft voice, enlarged breasts, enlargement of the hip area, and menarche. Therefore, this research aims to know the effect of acupressure therapy on the intensity of menstrual pain in female students at STIKes Yatsi Tangerang. This type of research is a quasi-experimental research that design isuses basedion igroup ipre-test iand ipost-test. iThe ipopulation iin ithis istudy iwas ia iLevel iII iMidwifery istudent iat iSTIKes iYatsi. Besides, the research was carried out in March 2022. Eventually, there is a change in menstrual pain in second-level female students at STIKes Yatsi before and after acupressure therapy.

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Aranda-Camacho, Yesid, and Jesús Alberto Cortés-Leal. "Inventario y priorización de recursos específicos para la gestión activa del turismo rural: estudio de caso del corregimiento de Palomino, Dibulla (Colombia)." Ambiente y Desarrollo 21, no. 40 (June 30, 2017): 93. http://dx.doi.org/10.11144/javeriana.ayd21-40.ipre.

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La gestión activa del turismo requiere valorar los recursos del territorio que soportan el desarrollo de la actividad. Palomino cuenta con recursos específicos que lo han convertido en un destino de turismo receptivo. Este trabajo identifica y prioriza participativamente los recursos con potencial de aprovechamiento turístico. Se siguió la metodología para la elaboración del inventario de atractivos turísticos y en la priorizaron se usaron criterios de representatividad y potencial de aprovechamiento. Además, los recursos se clasifican a partir del gobierno de los comunes. Los resultados aportan elementos para la adecuada planificación turística en el territorio.

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12

Okrepilov, V. V., and N. L. Gagulina. "On Ensuring the Quality of Life in the Innovative Economy of St. Petersburg from the Strategic Perspective." Economics and Management 27, no. 11 (November 30, 2021): 890–99. http://dx.doi.org/10.35854/1998-1627-2021-11-890-899.

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Aim. The presented study aims to analyze quality-of-life estimates obtained for St. Petersburg using a theoretical and methodological approach developed based on the concept of the qualitydriven economy.Tasks. The authors consider the concept of the quality of life in the context of the Strategy of socio-economic development of St. Petersburg until 2035; measure and analyze quality-of-life indicators based on the concept of the quality-driven economy.Methods. A major part of this study is based on the methodology of the general scientific philosophical approach and uses such methods of interdisciplinary research as modeling, system analysis, and others. The quality of life is measured on the theoretical and methodological basis of the quality-driven economy using the methodology developed at the Institute of Problems of Regional Economics (IPRE) of the Russian Academy of Sciences.Results. Ensuring a high quality of life for the population of the region is a priority goal of the functioning and development of the economy of St. Petersburg. To this end, it is crucial to use strategic opportunities for economic growth and regional development in achieving the social well-being of the region’s population. Different views on the understanding of the quality of life as the main strategic priority of the innovative development of St. Petersburg are analyzed, and quality-of-life estimates are obtained for St. Petersburg, the Northwestern Federal District (NWFD), and the Russian Federation as a whole. The role of St. Petersburg in enhancing the competitiveness of the economy of the Northwestern Federal District and Russia in the context of innovative development is shown.Conclusions. Quality of life is an integral part of the strategic planning system in the innovative economy of St. Petersburg. The quality-driven economy provides a reliable theoretical and methodological basis for making allowance for the quality of life at the highest levels of regional government. The analysis based on the results of calculations shows a correlation between the system of quality indicators of the methodology for measuring the quality of life to increase regional management efficiency developed at the IPRE RAS and several indicators of the strategic planning system of socioeconomic development in St. Petersburg. Thus, the application of quality-driven economy principles in the innovative economy of St. Petersburg makes it possible not only to set the initial conditions for achieving the necessary quality of life, but also to develop a mechanism that would ensure the achievement of this goal in the future.

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Yuli Setiyaningsih, Fera, and Any Isro’aini. "Pengaruh Aroma Terapi Papperint Terhadap Mual Muntah Pada Ibu Hamil Trimester I." Journal of Health Educational Science And Technology 5, no. 1 (June 14, 2022): 25–36. http://dx.doi.org/10.25139/htc.v5i1.4506.

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Abstrak : Konsepsi atau pembuahan adalah penyatuan sel telur dengan sperma yang kemudian akan berkembang menjadi embrio dan terus berkembang menjadi janin, dan lahirlah bayi. Mual dan muntah pada kehamilan berlebihan atau hiperemesis gravidarum tidak hanya mengancam nyawa ibu hamil, tetapi juga dapat menimbulkan efek samping pada janin seperti abortus, berat badan lahir rendah, kelahiran prematur, dan malformasi pada bayi baru lahir. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh aromaterapi peppermint pada ibu hamil trimester I. Jenis penelitian ini adalah pre-experimental design dengan Group Pre-test Post-test Designs. Teknik pengambilan sampel yang digunakan adalah purposive sampling, dengan penentuan jumlah sampel dalam penelitian ini adalah 20 ibu hamil trimester I. Instrumen yang dapat digunakan antara lain lembar observasi, pedoman observasi (pengamatan), atau lembar checklist. analisis menggunakan SPSS 18. Hasil penelitian menunjukkan bahwa sebelum responden mendapatkan aromaterapi peppermint, separuhnya mengalami mual dan muntah dengan tingkat mual dan muntah sedang. Setelah responden mendapatkan aromaterapi peppermint, sebagian besar mengalami mual dan muntah dengan tingkat mual dan muntah ringan. Dari analisis data di atas diketahui nilai signifikansi sebesar 0,000 artinya nilai signifikansi <, sehingga dapat diketahui bahwa pemberian aromaterapi peppermint berpengaruh terhadap mual muntah pada ibu hamil pada trimester I. Pemberian aromaterapi peppermint berpengaruh terhadap mual dan muntah pada ibu hamil trimester 1. Diharapkan peneliti selanjutnya dapat melakukan penelitian lebih lanjut mengenai teknik nonfarmakologi yang efektif dalam menurunkan intensitas mual muntah pada ibu hamil. Kata kunci : Aromaterapi Peppermint, Mual Muntah, Kehamilan Abstrack : Conception ior ifertilization iis ithe iunion iof ian iegg icell iwith ia isperm iwhich iwill ithen idevelop iinto ian iembryo iand icontinue ito idevelop iinto ia ifetus, iand ia ibaby iis iborn. iNausea iand ivomiting iin iexcessive ipregnancy ior ihyperemesis igravidarum inot ionly ithreaten ithe ilife iof ipregnant iwomen, ibut ican ialso icause iside ieffects ion ithe ifetus isuch ias iabortion, ilow ibirth iweight, ipremature ibirth, iand imalformations iin inewborns. iThe ipurpose iof ithis istudy iwas ito idetermine ithe ieffect iof ipeppermint iaromatherapy ion ipregnant iwomen iin ithe i1st itrimester. This itype iof iresearch iis ia ipre-experimental idesign iwith iGroup iPre-test iPost-test iDesigns. iThe isampling itechnique iused iwas ipurposive isampling, iwith ithe idetermination iof ithe isample isize iin ithe istudy ibeing i20 ifirst itrimester ipregnant iwomen. iInstruments ithat ican iuse iinclude iobservation isheets, iobservation iguides i(observations), ior ichecklist isheets. ianalyze iusing iSPSS i18. The iresults ishowed ithat ibefore ithe irespondents ireceived ipeppermint iaromatherapy, ihalf iof ithem iexperienced inausea iand ivomiting iwith imoderate ilevels iof inausea iand ivomiting. iAfter irespondents ireceived ipeppermint iaromatherapy, imost iof ithem iexperienced inausea iand ivomiting iwith imild ilevels iof inausea iand ivomiting. iFrom ithe ianalysis iof ithe idata iabove, iit's iknown ithat ithe isignificance ivalue iis i0.000, imeaning ithat ithe isignificance ivalue iis, iso iit ican isee ithat igiving ipeppermint iaromatherapy iaffects inausea iand ivomiting iin ipregnant iwomen iin ithe i1st itrimester. Giving ipeppermint iaromatherapy iaffects inausea iand ivomiting iin ipregnant iwomen iin ithe i1st itrimester. iIt's ihoped ithat ifuture iresearchers iwill ibe iable ito iconduct ifurther iresearch ion inon-pharmacological itechniques ithat iare ieffective iin ireducing ithe iintensity iof inausea iand ivomiting iin ipregnant iwomen. Keywords : Peppermint Aromatherapy, Nausea Vomiting, Pregnancy

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Pirlot, Gérard. "« Solus Ipse »." Adolescence 51, no. 1 (2005): 79. http://dx.doi.org/10.3917/ado.051.0079.

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Bernardo, Wanderley. "Ipse Dixit." Revista da Associação Médica Brasileira 66, suppl 2 (2020): 1–2. http://dx.doi.org/10.1590/1806-9282.66.s2.1.

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McLay, W. D. S. "IPSE Dixit." Science & Justice 36, no. 1 (January 1996): 68. http://dx.doi.org/10.1016/s1355-0306(96)72564-9.

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Szweda, Roy, and Joe Lorenzo. "IPRM'94." III-Vs Review 7, no. 6 (December 1994): 8. http://dx.doi.org/10.1016/0961-1290(94)90097-3.

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Szweda, Roy. "IPRM report." III-Vs Review 7, no. 3 (June 1994): 24. http://dx.doi.org/10.1016/0961-1290(94)90307-7.

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Janca, A., A. Loranger, and N. Sartorius. "IPDE status." European Psychiatry 11 (January 1996): 216s. http://dx.doi.org/10.1016/0924-9338(96)88631-7.

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Segabinazzi, Lorenzo G. T. M., Luiz R. P. Andrade, Marco A. Alvarenga, Jose A. Dell’Aqua, and Igor F. Canisso. "Use of Intravaginal Progesterone-Releasing Device Results in Similar Pregnancy Rates and Losses to Long-Acting Progesterone to Synchronize Acyclic Embryo Recipient Mares." Veterinary Sciences 8, no. 9 (September 10, 2021): 190. http://dx.doi.org/10.3390/vetsci8090190.

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The objectives of this study were: (1) to assess uterine features and serum progesterone concentrations of acyclic mares synchronized and resynchronized with intravaginal progesterone release device (IPRD), and (2) to compare pregnancy rates and losses of cyclic and acyclic embryo recipient mares treated with different synchronization protocols. In Experiment 1, mares (n = 12) received estradiol for 3 days (E2-3d), and then 24 h after the last injection, an IPRD was inserted and kept in place for 9 days. Three days after IPRD removal, mares were treated with E2-3d, and then a new IPRD was inserted and maintained for three days. Serum progesterone concentrations were assessed 2, 6, and 12 h after insertion and removal of IPRD, and then daily from the insertion of the first IPRD to one day after removal of the second IPRD. Experiment 2 was conducted with embryo recipient mares randomly assigned to four groups: (1) Cyclic: mares (n = 75) had ovulation confirmed after receiving a single dose of histrelin when a periovulatory follicle was first detected, (2) LAP4: acyclic mares (n = 92) were treated with E2-3d and then administered a single dose of LAP4 24 h after the last estradiol injection, (3) IPRD: acyclic mares (n = 130) were treated with E2-3d and an IPRD for 4–8 days, and (4) RE-IPRD: acyclic mares (n = 32) were synchronized as in the IPRD group but not used for embryo transfer (ET), then 8 to 15 days later, the mares were resynchronized with E2-3d and an IPRD for 4–8 days. In vivo-produced Day-8 embryos were collected and transferred 4–8 days after ovulation or progesterone treatments. Mares in IPRD and RE-IPRD groups had the intravaginal device removed immediately before ET, and then a new IPRD was inserted right after ET. Pregnancy diagnosis was performed at 5, 30, and 60 days after ET. Once pregnancy was confirmed, mares in the three acyclic groups received weekly injections of LAP4 (1.5 g) until 120 days of pregnancy. Mares in IPRD and RE-IPRD groups had the device removed three days after the first pregnancy diagnosis. In Experiment 1, progesterone concentrations increased rapidly starting 2 h after insertion of IPRD (p < 0.05); then, concentrations plateaued well above pregnancy maintenance until removal on days 9 and 3, respectively. Progesterone concentrations were reduced to baseline 24 h after IPRD removal (p < 0.05). For experiment 2, there was no difference in pregnancy rates across groups (65–74%) or pregnancy losses by 60 days of gestation (7–12%) (p > 0.05). In conclusion, the IPRD used herein resulted in a rapid increase and a sharp decline in progesterone concentrations upon its insertion and removal, respectively. Finally, our results demonstrated that IPRD could be a compatible alternative to LAP4 to synchronize and resynchronize acyclic embryo recipient mares.

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Ackerman, A. Bernard. "Res Ipse Loquitur!" American Journal of Dermatopathology 28, no. 6 (December 2006): 546–47. http://dx.doi.org/10.1097/01.dad.0000245206.90257.6e.

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Pariser, David. "Res ipse loquitur." Contemporary Psychology: A Journal of Reviews 38, no. 1 (January 1993): 107. http://dx.doi.org/10.1037/033006.

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SHOKEIR, A. A., N. BARAKAT, A. M. HUSSEIN, A. AWADALLA, A. M. HARRAZ, S. KHATER, K. HEMMAID, and A. I. KAMAL. "Activation of Nrf2 by Ischemic Preconditioning and Sulforaphane in Renal Ischemia/Reperfusion Injury: a Comparative Experimental Study." Physiological Research, June 17, 2015, 313–23. http://dx.doi.org/10.33549/physiolres.932834.

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Objectives of the study were to investigate impact of ischemic preconditioning (Ipre) and sulforaphane (SFN) and combination of them on nuclear factor 2 erythroid related factor 2 (Nrf2) gene and its dependent genes, heme oxygenase-1 (HO1) and NADPH-quinone oxidoreductase1 (NQO-1) and inflammatory cytokines TNF-α, IL1β, and intercellular adhesion molecule-1 (ICAM1) and caspase-3 in renal ischemia/reperfusion (I/R) injury. Ninety male Sprague Dawely rats were classified into 5 groups (each consists of 18 rats): sham, control, Ipre, sulforaphane and Sulfo+Ipre. Each group was subdivided into 3 subgroups each containing 6 rats according to time of harvesting kidney and taking blood samples; 24 h, 48 h, and 7 days subgroups. Renal functions including serum creatinine, BUN were measured at basal conditions and by the end of experiment. Expression of Nrf2, HO-1, NQO-1, TNF-α, IL-1β, and ICAM-1 was measured by real time PCR in kidney tissues by the end of experiment. Also, immunohistochemical localization of caspase-3 and chemical assay of malondialdehyde (MDA), GSH and SOD activity were measured in kidney tissues. Both Ipre and SFN improved kidney functions, enhanced the expression of Nrf2, HO-1, and NQO-1, attenuated the expression of inflammatory (TNF-α, IL-1, and ICAM-1) and apoptotic (caspase-3) markers. However, the effect of sulforaphane was more powerful than Ipre. Also, a combination of them caused more improvement in antioxidant genes expression and more attenuation in inflammatory genes but not caspase-3 than each one did separately. Sulforaphane showed more powerful effect in renoprotection against I/R injury than Ipre as well as there might be a synergism between them at the molecular but not at the function level.

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Sárközy, Márta, Fanni Magdolna Márványkövi, Gergő Szűcs, Zsuzsanna Z. A. Kovács, Márton R. Szabó, Renáta Gáspár, Andrea Siska, et al. "Ischemic preconditioning protects the heart against ischemia-reperfusion injury in chronic kidney disease in both males and females." Biology of Sex Differences 12, no. 1 (September 6, 2021). http://dx.doi.org/10.1186/s13293-021-00392-1.

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Abstract Background Uremic cardiomyopathy is a common cardiovascular complication of chronic kidney disease (CKD) characterized by left ventricular hypertrophy (LVH) and fibrosis enhancing the susceptibility of the heart to acute myocardial infarction. In the early stages of CKD, approximately 60% of patients are women. We aimed to investigate the influence of sex on the severity of uremic cardiomyopathy and the infarct size-limiting effect of ischemic preconditioning (IPRE) in experimental CKD. Methods CKD was induced by 5/6 nephrectomy in 9-week-old male and female Wistar rats. Two months later, serum and urine laboratory parameters were measured to verify the development of CKD. Transthoracic echocardiography was performed to assess cardiac function and morphology. Cardiomyocyte hypertrophy and fibrosis were measured by histology. Left ventricular expression of A- and B-type natriuretic peptides (ANP and BNP) were measured by qRT-PCR and circulating BNP level was measured by ELISA. In a subgroup of animals, hearts were perfused according to Langendorff and were subjected to 35 min global ischemia and 120 min reperfusion with or without IPRE (3 × 5 min I/R cycles applied before index ischemia). Then infarct size or phosphorylated and total forms of proteins related to the cardioprotective RISK (AKT, ERK1,2) and SAFE (STAT3) pathways were measured by Western blot. Results The severity of CKD was similar in males and females. However, CKD males developed more severe LVH compared to females as assessed by echocardiography. Histology revealed cardiac fibrosis only in males in CKD. LV ANP expression was significantly increased due to CKD in both sexes, however, LV BNP and circulating BNP levels failed to significantly increase in CKD. In both sexes, IPRE significantly decreased the infarct size in both the sham-operated and CKD groups. IPRE significantly increased the phospho-STAT3/STAT3 ratio in sham-operated but not in CKD animals in both sexes. There were no significant differences in phospho-AKT/AKT and phospho-ERK1,2/ERK1,2 ratios between the groups. Conclusion The infarct size-limiting effect of IPRE was preserved in both sexes in CKD despite the more severe uremic cardiomyopathy in male CKD rats. Further research is needed to identify crucial molecular mechanisms in the cardioprotective effect of IPRE in CKD.

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"Optimized Level Set Method for Segmentation of SAR Images using Adaptive Fuzzy-K-Means Clustering." International Journal of Engineering and Advanced Technology 9, no. 3 (February 29, 2020): 2039–49. http://dx.doi.org/10.35940/ijeat.c4858.029320.

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The icomplications ithat ioccurred iin iremote isensing iimage iinformation iand ianalysis ialgorithms igrowth iof ia ilarge iscale iimage isegmentation ihaven't ikept ia iplace iwith ithe irequirement ifor ithe imethods iwhich ito idevelop ithe ifinal iaccuracy iof iobject idetection ias iwell ias ithe irecognition. iTraditional iLevel iset isegmentation imethods iwhich iare iChan-Vese i(CV), iImage iand iVision iComputing i(IVC) i2010, iACM iwith iSBGFRLS, iand iOnline iRegion-Based iACM i(ORACM) iare isuffered ifrom imore iamounts iof itime icomplexity, ias iwell ias ilow isegmentation iaccuracy idue ito ilarge iintensity ihomogeneities iand ithe inoise iat iwhich ithe iregion ibased isegmentation iis iimpossible. iSo ithis iis ithe ireason, iwe iproposed ia inavel ihybrid imethodology icalled iadaptive iparticle iswarm ioptimization i(PSO) ibased iFuzzy iK-Means iclustering ialgorithm. iThe iproposed iapproach iis idiversified iinto itwo istages; iin istage ione, ipre-processing ithe iinput iimage ito iimprove ithe iclustering iefficiency iand iovercome ithe iobstacles ipresent iin itraditional imethods iby iusing iparticle iswarm ioptimization i(PSO) iand iAdaptive iFuzzy iK-means iclustering ialgorithm. iWith ithe ihelp iof ithe iPSO ialgorithm, iwe iget ithe i"optimum" ipixels ivalues iare iextracted ifrom ithe iinput iSAR iimages, ithese ioptimum ivalues iare iautomatically iacted ias iclusters icenters ifor iAdaptive iFuzzy iK-Means iClustering iinstead iof irandom iinitialization ifrom ithe ioriginal iimage. iThe ipre-processing isegmentation iresult iimproved ithe iclustering iefficiency ibut isuffers ifrom ifew idrawbacks isuch ias iboundary ileakages iand ioutliers ieven iparticle iSwarm ioptimization iis iused. iTo iovercome ithe iabove idrawbacks ipost-processing iis ineeded ito ifacilitate ithe isuperior isegmentation iresults iwith ithe ihelp iof ithe ilevel iset imethod. iIt iutilizes ian iefficient icurve ideformation idriven iby iexternal iand iinternal iforces ito icapture ithe iimportant istructures i(usual iedges) iin ian iimage. iThe icombined iapproach iof iboth ipre-processing iand ipost-processing iwhich iis icalled iParticle iSwarm iOptimization ibased iAdaptive iFuzzy-K-Means i(AFKM) iclustering ivia ithe ilevel iset imethod. iThe iproposed iapproach iis isuccessfully iimplemented ion ilarge iscale iremote isensing iimagery iand ithe idataset iare itaken ifrom ithe iopen-source iNASA iearth iobservatory idatabase ifor isegmenting ithe ioil islicker icreeps, ioil islicker iregions, ityphoon, isoulnik iand ithe iGulf iof iAlaska, ietc. iSo ihere iin ithis, ithe iproposed inew imethod ihad ifeasibility iand iefficiency iwhich icould iattain ithe ihigh iaccurate isegmentation iresults

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Kuret, A., R. Ehinger, H. Bischof, A. Luczak, A. Bausch, X. Zhou, R. Malli, P. Ruth, and R. Lukowski. "Cardioprotective actions of the sodium-activated potassium channel Slack (aka Slo2.2, KNa1.1 or KCNT1)." European Heart Journal 41, Supplement_2 (November 1, 2020). http://dx.doi.org/10.1093/ehjci/ehaa946.3646.

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Abstract Background Sodium-activated potassium channels (KNa) Slack (sequence like a calcium-activated potassium channel, aka Slo 2.2, KNa1.1 or KCNT1) are widely expressed throughout neuronal tissue, whereas their presence and function in the cardiovascular system is not well understood. Due to high intracellular sodium concentrations ([Na+]i) necessary to induce half-maximal channel activation, we hypothesized that Slack function is attributed to pathophysiological conditions such as myocardial ischemia. Purpose To elucidate the putative functions of Slack in the murine heart and in cardiomyocytes (CMs) and to explore whether the ischemia and reperfusion (I/R)-induced cardiac damage is affected by endogenous Slack channel activity. Methods I/R injury was evaluated in global and CM-specific Slack knockout mice (Slack gKO, CM Slack KO) and compared to litter-matched controls (Slack gWT, CM Slack CTR) by applying an in vivo model of acute myocardial infarction (MI). Infarct size (IS) was assessed at baseline, after ischemic pre- (iPre) and postconditioning (iPost) and in response to cinaciguat (CIN), a cGMP-elevating agent. Moreover, Slack expression and function in CMs was studied by biochemical and electrophysiological means and by utilizing the newly developed FRET-based K+ probe GEPII 1.0. Results IS in Slack gKO mice was increased in comparison to gWT littermates. In addition, the cardioprotection afforded by iPost was attenuated in the absence of Slack. To test if the increased vulnerability to I/R injury of the Slack gKO mouse model was originating from Slack activity in CMs, we subjected CM-specific Slack CTR and KO mutants to an identical MI procedure. IS measurements confirmed increased cardiac damage at baseline and reduced cardioprotective effects afforded by iPre and iPost in CM Slack KO mice. Interestingly, CIN (i.p., 30 min prior to I/R) reduced IS to a similar extent in both genotypes, suggesting that Slack functions in a cGMP-independent manner. Whole-cell patch clamp experiments on CMs demonstrated a reduction of the KNa-inhibitors clofilium- and chinidine-sensitive K+ outward currents in Slack gKO CM. Extracellular potassium ([K+]ex) accumulation measured with GEPII 1.0 was lower in Slack gKO versus gWT CM pools exposed to membrane permeabilizing agent digitonin. Accordingly, [K+]ex evoked by the Slack activators niclosamide and bithionol was lower in the absence of functional Slack in CMs. Conclusion The presented findings establish an important role of Slack channels for cardioprotective signalling mechanisms during I/R in vivo and for mediating beneficial effects of mechanical conditioning on IS. Corroborating in vitro studies on adult CMs exhibit an impaired [K+]ex dynamic in response to genetic or pharmacological modulation of Slack activity. Thus, we conclude that Slack-dependent K+ signalling pathways in CMs may represent a promising drug target that renders the heart muscle less vulnerable to the I/R-induced damage. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): Work in the authors' laboratories is supported by grants from the Deutsche Forschungsgemeinschaft (DFG) (to R.L.) and the DFG Research Unit 2060, “cGMP Signaling in Cell Growth and Survival” (to R.L. and P.R.).

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Mattila, Phyllis Ocran, Zaheer-Ud-Din Babar, and Fatima Suleman. "Assessing the prices and affordability of oncology medicines for three common cancers within the private sector of South Africa." BMC Health Services Research 21, no. 1 (July 6, 2021). http://dx.doi.org/10.1186/s12913-021-06627-6.

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Abstract Background Prices of cancer medicines are a major contributor to the cost of treatment for cancer patients and the comparison of these cost needs to be assessed. Objectives To assess the prices of cancer medicines for the three most common cancers ((breast, prostate and colorectal) in the private healthcare sector of South Africa. Methods The methodology was adapted from the World Health Organization (WHO)/ Health Action International (HAI) methodology for measuring medicine prices. The Single Exit Price (SEP) variations between product types of the same medicine between the highest- and lowest-priced product and between Originator Brand (OB) and its Lowest Priced Generic (LPG) of the same medicine brand was compared, as of March 2020. The affordability of those medicines for cancer usage based on treatment affordability in relation to the daily wage of the unskilled Lowest-Paid Government Worker (LPGW) was also determined. Also, a comparison of the proportion of the population below the poverty line (PL) before (Ipre) and after (Ipost) procurement of the cancer medicines was determined. Results SEP Price differences ranged from 25.46 to 97.33% between highest- and lowest-priced products and a price variation of 72.09% more for the OB than the LPG medicine, except for one LPG that was more expensive than the OB. Affordability calculations showed that All OB treatments for all three cancers (breast, prostate and colorectal), except for paclitaxel 300 mg (0.2 days wage) and Fluorouracil (Fluroblastin) 500 mg (0.3 days wage) costs respectively were more than 1 day’s wage, with patients diagnosed with colorectal cancer needing 32.5 days wages in order to afford a standard course of treatment for a month. Conclusion There was a considerable variation in the price of different brands of cancer medicines available in the South African private sector.

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"IPRA: International pragmatics association Why IPRA?" Journal of Pragmatics 10, no. 1 (February 1986): 153–58. http://dx.doi.org/10.1016/0378-2166(86)90108-6.

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Irtelli, Floriana. "Iper-Modern Paradoxes and Iper-Modern Symptoms." Psychology & Psychological Research International Journal 3, no. 8 (2018). http://dx.doi.org/10.23880/pprij-16000185.

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"IPRM 96." III-Vs Review 9, no. 1 (January 1996): 30. http://dx.doi.org/10.1016/s0961-1290(96)80167-0.

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"IPRM-V." III-Vs Review 6, no. 1 (February 1993): 63. http://dx.doi.org/10.1016/0961-1290(93)90039-q.

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"IPRM VI." Microelectronics Journal 24, no. 8 (December 1993): 715. http://dx.doi.org/10.1016/0026-2692(93)90060-r.

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"IPrA news service." Journal of Pragmatics 32, no. 10 (September 2000): 1551–55. http://dx.doi.org/10.1016/s0378-2166(00)90000-6.

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"IPrA News Service." Journal of Pragmatics 34, no. 5 (May 2002): 629–42. http://dx.doi.org/10.1016/s0378-2166(02)00023-1.

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"IPrA News Service." Journal of Pragmatics 34, no. 9 (September 2002): 1317–31. http://dx.doi.org/10.1016/s0378-2166(02)00082-6.

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"IPrA news service." Journal of Pragmatics 25, no. 2 (February 1996): 303–7. http://dx.doi.org/10.1016/s0378-2166(96)90009-0.

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"IPrA news service." Journal of Pragmatics 25, no. 1 (January 1996): 145–49. http://dx.doi.org/10.1016/s0378-2166(96)90015-6.

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"IPrA news service." Journal of Pragmatics 26, no. 1 (July 1996): 137–43. http://dx.doi.org/10.1016/s0378-2166(96)90027-2.

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"IPrA news service." Journal of Pragmatics 25, no. 5 (May 1996): 741–48. http://dx.doi.org/10.1016/s0378-2166(96)90033-8.

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"IPrA news service." Journal of Pragmatics 26, no. 2 (August 1996): 261–64. http://dx.doi.org/10.1016/s0378-2166(96)90039-9.

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"IPrA news service." Journal of Pragmatics 26, no. 6 (December 1996): 827–32. http://dx.doi.org/10.1016/s0378-2166(96)90045-4.

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"IPrA news service." Journal of Pragmatics 26, no. 4 (October 1996): 579–81. http://dx.doi.org/10.1016/s0378-2166(96)90051-x.

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"IPrA news service." Journal of Pragmatics 26, no. 3 (September 1996): 451–54. http://dx.doi.org/10.1016/s0378-2166(96)90055-7.

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"IPrA news service." Journal of Pragmatics 25, no. 4 (April 1996): 611–19. http://dx.doi.org/10.1016/s0378-2166(96)90069-7.

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"IPrA news service." Journal of Pragmatics 25, no. 3 (March 1996): 451–54. http://dx.doi.org/10.1016/s0378-2166(96)90075-2.

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"IPrA news service." Journal of Pragmatics 25, no. 6 (June 1996): 875–82. http://dx.doi.org/10.1016/s0378-2166(96)90077-6.

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"IPrA news service." Journal of Pragmatics 26, no. 5 (November 1996): 711–12. http://dx.doi.org/10.1016/s0378-2166(96)90080-6.

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"IPrA news service." Journal of Pragmatics 27, no. 3 (March 1997): 403–7. http://dx.doi.org/10.1016/s0378-2166(97)90003-5.

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"IPrA news service." Journal of Pragmatics 27, no. 5 (May 1997): 711–18. http://dx.doi.org/10.1016/s0378-2166(97)90007-2.

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"IPrA news section." Journal of Pragmatics 28, no. 1 (July 1997): 129–33. http://dx.doi.org/10.1016/s0378-2166(97)90015-1.

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