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Journal articles on the topic 'Ionoacoustic'

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Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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1

Lehrack, S., W. Assmann, M. Bender, D. Severin, C. Trautmann, J. Schreiber, and K. Parodi. "Ionoacoustic detection of swift heavy ions." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 950 (January 2020): 162935. http://dx.doi.org/10.1016/j.nima.2019.162935.

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2

Vallicelli, Elia Arturo, and Marcello De Matteis. "Analog Filters Design for Improving Precision in Proton Sound Detectors." Journal of Low Power Electronics and Applications 11, no. 1 (March 18, 2021): 12. http://dx.doi.org/10.3390/jlpea11010012.

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This paper analyzes how to improve the precision of ionoacoustic proton range verification by optimizing the analog signal processing stages with particular emphasis on analog filters. The ionoacoustic technique allows one to spatially detect the proton beam penetration depth/range in a water absorber, with interesting possible applications in real-time beam monitoring during hadron therapy treatments. The state of the art uses nonoptimized detectors that have low signal quality and thus require a higher total dose, which is not compatible with clinical applications. For these reasons, a comprehensive analysis of acoustic signal bandwidth, signal-to-noise-ratio and noise power/bandwidth will be presented. The correlation between these signal-quality parameters with maximum achievable proton range measurement precision will be discussed. In particular, the use of an optimized analog filter allows one to decrease the dose required to achieve a given precision by as much as 98.4% compared to a nonoptimized filter approach.

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3

Assmann, W., S. Kellnberger, S. Reinhardt, S. Lehrack, A. Edlich, P. G. Thirolf, M. Moser, et al. "Ionoacoustic characterization of the proton Bragg peak with submillimeter accuracy." Medical Physics 42, no. 2 (January 9, 2015): 567–74. http://dx.doi.org/10.1118/1.4905047.

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4

Vallicelli, Elia A., Michele Riva, Mario Zannoni, Andrea Baschirotto, and Marcello De Matteis. "Analog and Digital Signal Processing for Pressure Source Imaging at 190 MeV Proton Beam." EPJ Web of Conferences 216 (2019): 04003. http://dx.doi.org/10.1051/epjconf/201921604003.

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Oncological hadron therapy utilizes a beam of charged particles to destroy the tumor cells, exploiting the particular deposition curve that allow minimum damage to the surrounding healty tissues compared to traditional radiotherapy. Sulak and Hayakawa’s works have shown the applicability of this technique in clinical scenarios, but the lack of dedicated electronics for this type of experiments affects the spatial resolution that can be obtained with this technique [1]. This work presents an integrated analog front-end dedicated to ionoacoustic experiments that allows to estimate the position of the Bragg Peak with an average deviation of 1% with respect to the real position.

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5

Lehrack, Sebastian, Walter Assmann, Damien Bertrand, Sebastien Henrotin, Joel Herault, Vincent Heymans, Francois Vander Stappen, et al. "Submillimeter ionoacoustic range determination for protons in water at a clinical synchrocyclotron." Physics in Medicine & Biology 62, no. 17 (August 18, 2017): L20—L30. http://dx.doi.org/10.1088/1361-6560/aa81f8.

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6

Wieser, H. P., Y. Huang, J. Schauer, J. Lascaud, M. Würl, S. Lehrack, D. Radonic, et al. "Experimental demonstration of accurate Bragg peak localization with ionoacoustic tandem phase detection (iTPD)." Physics in Medicine & Biology 66, no. 24 (December 16, 2021): 245020. http://dx.doi.org/10.1088/1361-6560/ac3ead.

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Abstract Accurate knowledge of the exact stopping location of ions inside the patient would allow full exploitation of their ballistic properties for patient treatment. The localized energy deposition of a pulsed particle beam induces a rapid temperature increase of the irradiated volume and leads to the emission of ionoacoustic (IA) waves. Detecting the time-of-flight (ToF) of the IA wave allows inferring information on the Bragg peak location and can henceforth be used for in-vivo range verification. A challenge for IA is the poor signal-to-noise ratio at clinically relevant doses and viable machines. We present a frequency-based measurement technique, labeled as ionoacoustic tandem phase detection (iTPD) utilizing lock-in amplifiers. The phase shift of the IA signal to a reference signal is measured to derive the ToF. Experimental IA measurements with a 3.5 MHz lead zirconate titanate (PZT) transducer and lock-in amplifiers were performed in water using 22 MeV proton bursts. A digital iTPD was performed in-silico at clinical dose levels on experimental data obtained from a clinical facility and secondly, on simulations emulating a heterogeneous geometry. For the experimental setup using 22 MeV protons, a localization accuracy and precision obtained through iTPD deviates from a time-based reference analysis by less than 15 μm. Several methodological aspects were investigated experimentally in systematic manner. Lastly, iTPD was evaluated in-silico for clinical beam energies indicating that iTPD is in reach of sub-mm accuracy for fractionated doses < 5 Gy. iTPD can be used to accurately measure the ToF of IA signals online via its phase shift in frequency domain. An application of iTPD to the clinical scenario using a single pulsed beam is feasible but requires further development to reach <1 Gy detection capabilities.

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7

Riva, Michele, Elia A. Vallicelli, Andrea Baschirotto, and Marcello De Matteis. "Modeling the Acoustic Field Generated by a Pulsed Beam for Experimental Proton Range Verification." EPJ Web of Conferences 216 (2019): 03005. http://dx.doi.org/10.1051/epjconf/201921603005.

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Proton range verification by ionoacoustic wave sensing is a technique under development for applications in adron therapy as an alternative to nuclear imaging. It provides an acoustic imaging of the proton energy deposition vs. depth using the acoustic wave Time of Flight (ToF). State-of-the-art (based on simulations and experimental results) points out that this detection technique achieves better spatial resolution (< 1 mm) of the proton range comparing with Positron-Emission-Tomography (PET) and prompt gamma ray techniques. This work presents a complete Geant4/k-Wave model that allows to understand several physical phenomena and to evaluate the key parameters that affect the acoustic field generated by the incident proton radiation.

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8

Schauer, J., J. Lascaud, Y. Huang, M. Vidal, J. Hérault, G. Dollinger, K. Parodi, and H. P. Wieser. "FEASABILITY STUDY OF IONOACOUSTIC SIGNAL DETECTION UNDER FLASH CONDITIONS AT A CLINICAL SYNCHROCYLOTRON FACILITY." Physica Medica 94 (February 2022): S111—S112. http://dx.doi.org/10.1016/s1120-1797(22)01696-9.

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9

Lascaud, Julie, Pratik Dash, Hans-Peter Wieser, Ronaldo Kalunga, Matthias Würl, Walter Assmann, and Katia Parodi. "Investigating the accuracy of co-registered ionoacoustic and ultrasound images in pulsed proton beams." Physics in Medicine & Biology 66, no. 18 (September 9, 2021): 185007. http://dx.doi.org/10.1088/1361-6560/ac215e.

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10

Patch, Sarah K., Daniel E. M. Hoff, Tyler B. Webb, Lee G. Sobotka, and Tianyu Zhao. "Two-stage ionoacoustic range verification leveraging Monte Carlo and acoustic simulations to stably account for tissue inhomogeneity and accelerator-specific time structure - A simulation study." Medical Physics 45, no. 2 (December 21, 2017): 783–93. http://dx.doi.org/10.1002/mp.12681.

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11

van Dongen, K. W. A., A. J. de Blécourt, E. Lens, D. R. Schaart, and F. M. Vos. "Reconstructing 3D proton dose distribution using ionoacoustics." Physics in Medicine & Biology 64, no. 22 (November 15, 2019): 225005. http://dx.doi.org/10.1088/1361-6560/ab4cd5.

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12

Lehrack, S., W. Assmann, and K. Parodi. "Ionoacoustics for range monitoring of proton therapy." Journal of Physics: Conference Series 1154 (January 2019): 012015. http://dx.doi.org/10.1088/1742-6596/1154/1/012015.

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13

Parodi, Katia, and Walter Assmann. "Ionoacoustics: A new direct method for range verification." Modern Physics Letters A 30, no. 17 (May 22, 2015): 1540025. http://dx.doi.org/10.1142/s0217732315400258.

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The superior ballistic properties of ion beams may offer improved tumor-dose conformality and unprecedented sparing of organs at risk in comparison to other radiation modalities in external radiotherapy. However, these advantages come at the expense of increased sensitivity to uncertainties in the actual treatment delivery, resulting from inaccuracies of patient positioning, physiological motion and uncertainties in the knowledge of the ion range in living tissue. In particular, the dosimetric selectivity of ion beams depends on the longitudinal location of the Bragg peak, making in vivo knowledge of the actual beam range the greatest challenge to full clinical exploitation of ion therapy. Nowadays, in vivo range verification techniques, which are already, or close to, being investigated in the clinical practice, rely on the detection of the secondary annihilation photons or prompt gammas, resulting from nuclear interaction of the primary ion beam with the irradiated tissue. Despite the initial promising results, these methods utilize a not straightforward correlation between nuclear and electromagnetic processes, and typically require massive and costly instrumentation. On the contrary, the long-term known, yet only recently revisited process of "ionoacoustics", which is generated by local tissue heating especially at the Bragg peak, may offer a more direct approach to in vivo range verification, as reviewed here.

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14

Lehrack, S., W. Assmann, A. Maaß, K. Baumann, G. Dedes, S. Reinhardt, P. Thirolf, et al. "Range Verification with Ionoacoustics: simulations and measurements at a clinical proton synchro-cyclotron." Radiotherapy and Oncology 118 (February 2016): S66—S67. http://dx.doi.org/10.1016/s0167-8140(16)30135-9.

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15

Lascaud, J., M. Pinto, P. Dash, H. P. Wieser, R. Rouffaud, D. Certon, M. Sitarz, P. Poulsen, and K. Parodi. "FLASH Modalities Track (Oral Presentations) FEASIBILITY STUDY OF TRANSIENT IONOACOUSTICS-BASED PROTON BEAM MONITORING FOR SMALL ANIMAL IRRADIATION AT CYCLOTRON-BASED CLINICAL FACILITIES UNDER FLASH CONDITIONS." Physica Medica 94 (February 2022): S19—S20. http://dx.doi.org/10.1016/s1120-1797(22)01475-2.

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16

Lascaud, Julie, Pratik Dash, Matthias Würl, Hans-Peter Wieser, Benjamin Wollant, Ronaldo Kalunga, Walter Assmann, et al. "Enhancement of the ionoacoustic effect through ultrasound and photoacoustic contrast agents." Scientific Reports 11, no. 1 (February 1, 2021). http://dx.doi.org/10.1038/s41598-021-81964-4.

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AbstractThe characteristic depth dose deposition of ion beams, with a maximum at the end of their range (Bragg peak) allows for local treatment delivery, resulting in better sparing of the adjacent healthy tissues compared to other forms of external beam radiotherapy treatments. However, the optimal clinical exploitation of the favorable ion beam ballistic is hampered by uncertainties in the in vivo Bragg peak position. Ionoacoustics is based on the detection of thermoacoustic pressure waves induced by a properly pulsed ion beam (e.g., produced by modern compact accelerators) to image the irradiated volume. Co-registration between ionoacoustics and ultrasound imaging offers a promising opportunity to monitor the ion beam and patient anatomy during the treatment. Nevertheless, the detection of the ionoacoustic waves is challenging due to very low pressure amplitudes and frequencies (mPa/kHz) observed in clinical applications. We investigate contrast agents to enhance the acoustic emission. Ultrasound microbubbles are used to increase the ionoacoustic frequency around the microbubble resonance frequency. Moreover, India ink is investigated as a possible mean to enhance the signal amplitude by taking advantage of additional optical photon absorption along the ion beam and subsequent photoacoustic effect. We report amplitude increase of up to 200% of the ionoacoustic signal emission in the MHz frequency range by combining microbubbles and India ink contrast agents.

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17

Lascaud, Julie, Pratik Kumar Dash, Katrin Schnürle, Jonathan Bortfeldt, Katharina Beatrice Niepel, Jessica Maas, Matthias Wuerl, et al. "Fabrication and characterization of a multimodal 3D printed mouse phantom for ionoacoustic quality assurance in image-guided pre-clinical proton radiation research." Physics in Medicine & Biology, September 7, 2022. http://dx.doi.org/10.1088/1361-6560/ac9031.

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Abstract Objectives Image guidance and precise irradiation are fundamental to ensure the reliability of small animal oncology studies. Accurate positioning of the animal and the in-beam monitoring of the delivered radio-therapeutic treatment necessitate several imaging modalities. In the particular context of proton therapy with a pulsed beam, information on the delivered dose can be retrieved by monitoring the thermoacoustic waves resulting from the brief and local energy deposition induced by a proton beam (ionoacoustics). The objective of this work was to fabricate a multimodal phantom (x-ray, proton, ultrasound, and ionoacoustic) allowing for sufficient imaging contrast for all the modalities. Approach The phantom anatomical parts were extracted from mouse computed tomography scans and printed using polylactic acid (organs) and a granite / polylactic acid composite (skeleton). The anatomical pieces were encapsulated in silicone rubber to ensure long term stability. The phantom was imaged using x-ray cone-beam computed tomography, proton radiography, ultrasound imaging, and monitoring of a 20 MeV pulsed proton beam using ionoacoustics. Main results The anatomical parts could be visualized in all the imaging modalities validating the phantom capability to be used for multimodal imaging. Ultrasound images were simulated from the x-ray cone-beam computed tomography and co-registered with ultrasound images obtained before the phantom irradiation and low-resolution ultrasound images of the mouse phantom in the irradiation position, co-registered with ionoacoustic measurements. The latter confirmed the irradiation of a tumor surrogate for which the reconstructed range was found to be in reasonable agreement with the expectation. Significance This study reports on a realistic small animal phantom which can be used to investigate ionoacoustic range (or dose) verification together with ultrasound, x-ray, and proton imaging. The co-registration between ionoacoustic reconstructions of the impinging proton beam and x-ray imaging is assessed for the first time in a pre-clinical scenario.

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18

Schauer, Jannis, Hans-Peter Wieser, Yuanhui Huang, Heinrich Ruser, Julie Lascaud, Matthias Würl, Andriy Chmyrov, et al. "Proton beam range verification by means of ionoacoustic measurements at clinically relevant doses using a correlation-based evaluation." Frontiers in Oncology 12 (November 3, 2022). http://dx.doi.org/10.3389/fonc.2022.925542.

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PurposeThe Bragg peak located at the end of the ion beam range is one of the main advantages of ion beam therapy compared to X-Ray radiotherapy. However, verifying the exact position of the Bragg peak within the patient online is a major challenge. The goal of this work was to achieve submillimeter proton beam range verification for pulsed proton beams of an energy of up to 220 MeV using ionoacoustics for a clinically relevant dose deposition of typically 2 Gy per fraction by i) using optimal proton beam characteristics for ionoacoustic signal generation and ii) improved signal detection by correlating the signal with simulated filter templates.MethodsA water tank was irradiated with a preclinical 20 MeV proton beam using different pulse durations ranging from 50 ns up to 1 μs in order to maximise the signal-to-noise ratio (SNR) of ionoacoustic signals. The ionoacoustic signals were measured using a piezo-electric ultrasound transducer in the MHz frequency range. The signals were filtered using a cross correlation-based signal processing algorithm utilizing simulated templates, which enhances the SNR of the recorded signals. The range of the protons is evaluated by extracting the time of flight (ToF) of the ionoacoustic signals and compared to simulations from a Monte Carlo dose engine (FLUKA).ResultsOptimised SNR of 28.0 ± 10.6 is obtained at a beam current of 4.5 μA and a pulse duration of 130 ns at a total peak dose deposition of 0.5 Gy. Evaluated ranges coincide with Monte Carlo simulations better than 0.1 mm at an absolute range of 4.21 mm. Higher beam energies require longer proton pulse durations for optimised signal generation. Using the correlation-based post-processing filter a SNR of 17.8 ± 5.5 is obtained for 220 MeV protons at a total peak dose deposition of 1.3 Gy. For this clinically relevant dose deposition and proton beam energy, submillimeter range verification was achieved at an absolute range of 303 mm in water.ConclusionOptimal proton pulse durations ensure an ideal trade-off between maximising the ionoacoustic amplitude and minimising dose deposition. In combination with a correlation-based post-processing evaluation algorithm, a reasonable SNR can be achieved at low dose levels putting clinical applications for online proton or ion beam range verification into reach.

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19

Sueyasu, Shota, Taisuke Takayanagi, Koichi Miyazaki, Yasutoshi Kuriyama, Yoshihiro Ishi, Tomonori Uesugi, Mehmet Burcin Unlu, et al. "Ionoacoustic application of an optical hydrophone to detect proton beam range in water." Medical Physics, December 24, 2022. http://dx.doi.org/10.1002/mp.16189.

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20

Kellnberger, Stephan, Walter Assmann, Sebastian Lehrack, Sabine Reinhardt, Peter Thirolf, Daniel Queirós, George Sergiadis, Günther Dollinger, Katia Parodi, and Vasilis Ntziachristos. "Ionoacoustic tomography of the proton Bragg peak in combination with ultrasound and optoacoustic imaging." Scientific Reports 6, no. 1 (July 7, 2016). http://dx.doi.org/10.1038/srep29305.

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21

Takayanagi, Taisuke, Tomoki Uesaka, Yuta Nakamura, Mehmet Burcin Unlu, Yasutoshi Kuriyama, Tomonori Uesugi, Yoshihiro Ishi, et al. "On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency." Scientific Reports 10, no. 1 (November 23, 2020). http://dx.doi.org/10.1038/s41598-020-77422-2.

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AbstractIn contrast to conventional X-ray therapy, proton beam therapy (PBT) can confine radiation doses to tumours because of the presence of the Bragg peak. However, the precision of the treatment is currently limited by the uncertainty in the beam range. Recently, a unique range verification methodology has been proposed based on simulation studies that exploit spherical ionoacoustic waves with resonant frequency (SPIREs). SPIREs are emitted from spherical gold markers in tumours initially introduced for accurate patient positioning when the proton beam is injected. These waves have a remarkable property: their amplitude is linearly correlated with the residual beam range at the marker position. Here, we present proof-of-principle experiments using short-pulsed proton beams at the clinical dose to demonstrate the feasibility of using SPIREs for beam-range verification with submillimetre accuracy. These results should substantially contribute to reducing the range uncertainty in future PBT applications.

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22

Takayanagi, Taisuke, Tomoki Uesaka, Masanori Kitaoka, Mehmet Burcin Unlu, Kikuo Umegaki, Hiroki Shirato, Lei Xing, and Taeko Matsuura. "A novel range-verification method using ionoacoustic wave generated from spherical gold markers for particle-beam therapy: a simulation study." Scientific Reports 9, no. 1 (March 8, 2019). http://dx.doi.org/10.1038/s41598-019-38889-w.

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23

Nakamura, Yuta, Taisuke Takayanagi, Tomoki Uesaka, Mehmet Burcin Unlu, Yasutoshi Kuriyama, Yoshihiro Ishi, Tomonori Uesugi, et al. "Technical Note: Range verification of pulsed proton beams from fixed‐field alternating‐gradient accelerator by means of time‐of‐flight measurement of ionoacoustic waves." Medical Physics, June 26, 2021. http://dx.doi.org/10.1002/mp.15060.

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