Dissertations / Theses on the topic 'Ion mobility separation-mass spectrometry'
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Berezovskaya, Yana. "Investigation of protein-ion interactions by mass spectrometry and ion mobility mass spectrometry." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7747.
Full textWoods, Lucy Ann. "Characterising amyloid assembly using ion mobility spectrometry-mass spectrometry." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590277.
Full textZhou, Li. "Enhanced Electrospray Ionization for Mass Spectrometry and Ion Mobility Spectrometry." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1384.pdf.
Full textIsmail, Vian Sdiq Ismail. "Probing lipidation of membrane active peptides and integral membrane proteins by liquid chromatography-mass spectrometry and ion mobility separation-mass spectrometry." Thesis, Durham University, 2017. http://etheses.dur.ac.uk/12424/.
Full textDing, Luyi. "Studies of electrospray/ion mobility spectrometry/time-of-flight mass spectrometry." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0015/NQ48344.pdf.
Full textChawner, Ross. "Combined tandem mass spectrometry and ion mobility spectrometry in proteome analyses." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/combined-tandem-mass-spectrometry-and-ion-mobility-spectrometry-in-proteome-analyses(3ba76f18-4703-4f6e-a97f-ee2b1dfb1deb).html.
Full textKoeniger, Stormy Lee Ann. "Multidimensional ion mobility spectrometry coupled to time-of-flight mass spectrometry." [Bloomington, Ind.] : Indiana University, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3230539.
Full textTitle from PDF t.p. (viewed Nov. 5, 2008). Source: Dissertation Abstracts International, Volume: 67-08, Section: B, page: 4395. Adviser: David E. Clemmer.
Shliaha, Pavel Vyacheslavovich. "Investigation of protein abundance and localization by mass spectrometry and ion-mobility spectrometry-mass spectrometry methods." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708661.
Full textSmiljanic, Danijela. "Mass Spectrometry Interfaced with Ion Mobility or Liquid Chromatography Separation for the Analysis of Complex Mixtures." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1323149449.
Full textHofmann, Johanna [Verfasser]. "Ion Mobility-Mass Spectrometry of Complex Carbohydrates / Johanna Hofmann." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1141678438/34.
Full textKnight, Andrew Keith. "Advanced Detection Technology for Ion Mobility and Mass Spectrometry." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/193700.
Full textMa, Xin. "Ion Mobility Mass Spectrometry of DNA/SgrAI Nuclease Oligomers." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/247282.
Full textKatzenmeyer, Bryan C. "Interfacing Liquid Chromatography or Ion Mobility Separation with Mult-Dimensional Mass Spectrometry for the Structural Characterization of Polymeric Materials." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1367252830.
Full textFaull, Peter Allen. "Exploring gas-phase protein conformations by ion mobility-mass spectrometry." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3851.
Full textSoyk, Matthew W. "Instrumentation development for coupling ion/ion reactions and ion mobility in biological mass spectrometry." [Ames, Iowa : Iowa State University], 2008.
Find full textCool, Lydia R. "Identifying and Distinguishing Isomers Using Mass Spectrometry and Ion Mobility." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460470683.
Full textGöth, Melanie [Verfasser]. "Investigation of Protein-Ligand Complexes by Native Mass Spectrometry and Ion Mobility-Mass Spectrometry / Melanie Göth." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1149050594/34.
Full textBrown, Lauren J. "Field asymmetric waveform ion mobility spectrometry-mass spectrometry studies of peptides and proteins." Thesis, Loughborough University, 2013. https://dspace.lboro.ac.uk/2134/12001.
Full textGarabedian, Alyssa Lynn. "Study of Proteoforms, DNA and Complexes using Trapped Ion Mobility Spectrometry-Mass Spectrometry." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3567.
Full textLu, Yao. "Forensic Applications of Gas Chromatography-Differential Mobility Spectrometry, Gas Chromatography/Mass Spectrometry, and Ion Mobility Spectrometry with Chemometric Analysis." Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1267816777.
Full textGwak, Seongshin. "Comprehensive Analysis of Emerging New Psychoactive Substances by Ion Mobility Spectrometry and Mass Spectrometry." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2291.
Full textKnapman, Thomas William. "Structural analysis of biomolecules by nanoESI and travelling wave ion mobility spectrometry-mass spectrometry." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535122.
Full textHarry, Emma. "The development of ion mobility-mass spectrometry for complex mixture analysis." Thesis, Loughborough University, 2011. https://dspace.lboro.ac.uk/2134/9119.
Full textMalkar, Aditya. "Analytical methods based on ion mobility and mass spectrometry for metabolomics." Thesis, Loughborough University, 2014. https://dspace.lboro.ac.uk/2134/14524.
Full textDu, Chen. "Architectural Characterization of Polyhedral Oligomeric Silsesquioxanes by Ion Mobility Mass Spectrometry." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1525355186538632.
Full textSolak, Nilüfer. "Structural Characterization and Quantitative Analysis by Interfacing Liquid Chromatography and/or Ion Mobility Separation with Multi-Dimensional Mass Spectrometry." University of Akron / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=akron1270744150.
Full textHarris, Glenn A. "Fundamentals of ambient metastable-induced chemical ionization mass spectrometry and atmospheric pressure ion mobility spectrometry." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41147.
Full textAdams, Kendra J. "Discovery and Targeted Monitoring of Biomarkers Using Liquid Chromatography, Ion Mobility Spectrometry , and Mass Spectrometry." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3568.
Full textSpencer, John Edward. "ION MOTION AND AN OPTIMIZATION OF TANDEM MASS SPECTROMETRY." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_theses/211.
Full textBenigni, Paolo. "Trapped Ion Mobility Spectrometry coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for the analysis of Complex Mixtures." FIU Digital Commons, 2017. https://digitalcommons.fiu.edu/etd/3547.
Full textJin, Lan. "Investigating glycosaminoglycan conformations by ion mobility mass spectrometry and nuclear magnetic resonance." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/12304.
Full textSivalingam, G. N. "Advances in computational ion mobility mass spectrometry : with application to α1-antitrypsin." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1467251/.
Full textLapthorn, Cristian Lewis. "The application of ion mobility mass spectrometry to molecules of pharmaceutical significance." Thesis, University of Greenwich, 2016. http://gala.gre.ac.uk/18125/.
Full textFuller, Daniel Raymond. "Probing Structure and Stability of Biomolecules with Ion Mobility-mass Spectrometry Techniques." Thesis, Indiana University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10844168.
Full textIon mobility spectrometry – mass spectrometry (IMS-MS) based techniques have significantly advanced the study of both the structure and stability of biomolecules. Solution phase, biologically relevant peptide/protein conformations have been analyzed utilizing electrospray ionization (ESI) coupled to IMS-MS. The work presented here focuses on the development and application of IMS-MS for the study of the structure and stability of peptides and proteins. Structures originating in solution can be related to the biological activity of the system. Specifically, we examine the influence of both proline isomerization and metal binding on the conformational preferences and stabilities of a series of peptides and proteins.
The first study uses IMS-MS to examine the conformation specific binding of Zn2+ to oxytocin (OT). When bound to Zn, OT has an increased affinity for its receptor. We observe two conformations which are the result of the cis-trans orientation of the Cys6-Pro 7 bond. We find that Zn2+ binds preferentially to the trans configuration demonstrating that cis-trans isomerization regulates the binding of Zn2+ to OT, therefore linking the orientation of the Cys6-Pro7 bond to the biological activity of the molecule. In another series of experiments, we look at the role of penultimate proline on the stability of bradykinin along with a library of penultimate proline containing peptides. For BK, we find that the Pro2-Pro3 bond, which is enzymatically resistant, is cleaved with 100% specificity when incubated at high temperatures. With IMS-MS, we are able to monitor the mass spectral and conformational changes as a function of time, and find that cis-trans isomerization of a single bond regulates the rate of dissociation, and hence the stability of the system. Finally, we look at the thermal stability of the insulin-zinc hexamer complex. Utilizing temperature-controlled nano-ESI IMS-MS, we capture the dissociation of the insulin hexamer and the unfolding of insulin dimer and monomer, occurring simultaneously with increasing solution temperature. We show the ability of IMS-MS to observe the conformation specific melting temperatures of a protein complex, demonstrating a fast and sensitive assay for stability characterization.
Da, Costa Caitlyn. "Applications of desorption electrospray ionisation mass spectrometry and ion mobility spectrometry to petroleomic and lubricant analysis." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/21617.
Full textZhao, Qin. "Development of ion mobility mass spectrometry coupled with ion/ion reactions instrumentation and applications for protein analysis /." [Ames, Iowa : Iowa State University], 2009.
Find full textHarvey, Sophie Rebecca. "Biophysical studies into the structure and interactions of proteins and peptides." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9654.
Full textAlexander, Nicolas Edward. "Multidimensional Mass Spectrometry of Amphiphilic Systems." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1532773038466757.
Full textMolano-Arévalo, Juan Camilo. "Conformational Dynamics of Biomolecules by Trapped Ion Mobility Spectrometry Dynamics." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3647.
Full textBirdwell, David. "Soft Landing Ion Mobility Mass Spectrometry: History, Instrumentation and an Ambient Pressure Application." Thesis, University of North Texas, 2010. https://digital.library.unt.edu/ark:/67531/metadc33136/.
Full textAguilar, Ayala Roberto. "Applications of Metallic Clusters and Nanoparticles via Soft Landing Ion Mobility, from Reduced to Ambient Pressures." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1248434/.
Full textHopper, Jonathan T. S. "Studying protein-ligand complexes in the gas-phase using ion mobility-mass spectrometry." Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.576159.
Full textWright, Victoria E. "Ion mobility-mass spectrometry studies of organic and organometallic complexes and reaction monitoring." Thesis, Loughborough University, 2013. https://dspace.lboro.ac.uk/2134/14275.
Full textJurneczko, Ewa. "Resolving intrinsically disordered proteins of the cancer genome with ion mobility mass spectrometry." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/8844.
Full textFrerichs, Niklas. "Ion mobility mass spectrometry as a powerful tool to analyze complex macromolecular systems." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://hdl.handle.net/21.11130/00-1735-0000-0005-1560-7.
Full textSmith, Robert W. "An evaluation of miniaturised field asymmetric waveform ion mobility spectrometry hyphenated with time-of-flight mass spectrometry." Thesis, Loughborough University, 2014. https://dspace.lboro.ac.uk/2134/17837.
Full textYoung, Lydia Mary. "Defining the mechanism of small molecule inhibition of amyloid fibril formation using ion mobility spectrometry-mass spectrometry." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/11887/.
Full textAlawani, Nadrah. "Structural Characterization of Synthetic Polymers and Copolymers Using Multidimensional Mass Spectrometry Interfaced with Thermal Degradation, Liquid Chromatography and/or Ion Mobility Separation." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1386591497.
Full textVerbeck, Guido Fridolin. "Development of a variable-temperature ion mobility/ time-of-flight mass spectrometer for separation of electronic isomers." Texas A&M University, 2005. http://hdl.handle.net/1969.1/2310.
Full textGray, Christopher. "Comprehensive stereochemical sequencing of carbohydrates and characterisation of their binding partners using hyphenated mass spectrometry methods." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/comprehensive-stereochemical-sequencing-of-carbohydrates-and-characterisation-oftheir-binding-partners-using-hyphenated-mass-spectrometry-methods(0f606678-b7d1-4a5c-817a-fff2b9fab90a).html.
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