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Journal articles on the topic 'Ion imaging'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

SCHMITZ, R., L. BÜTFERING, and F. W. RÖLLGEN. "NEGATIVE ION IMAGING IN FIELD ION MICROSCOPY." Le Journal de Physique Colloques 47, no. C7 (November 1986): C7–53—C7–57. http://dx.doi.org/10.1051/jphyscol:1986710.

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2

Zhu, Cheng, Kaixiang Huang, Yunong Wang, Kristen Alanis, Wenqing Shi, and Lane A. Baker. "Imaging with Ion Channels." Analytical Chemistry 93, no. 13 (March 24, 2021): 5355–59. http://dx.doi.org/10.1021/acs.analchem.1c00224.

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3

Levi-Setti, R., J. M. Chabala, C. Girod-Hallegot, P. Hallegot, and Y. L. Wang. "Secondary ion imaging microanalysis." Proceedings, annual meeting, Electron Microscopy Society of America 47 (August 6, 1989): 8–9. http://dx.doi.org/10.1017/s042482010015201x.

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The goals of high spatial resolution and high elemental sensitivity in the imaging microanalysis of biological tissues and materials have, to a large extent, been attained by using the method of secondary ion mass spectrometry (SIMS) following bombardment of a sample surface by a focused beam of heavy ions. The instrument that we will discuss and which has achieved these goals is a scanning ion microprobe originally developed in collaboration with Hughes Research Laboratories (UC-HRL SIM). It utilizes a 40-60 keV Ga+ probe, extracted from a point-like liquid metal ion source, that can be focused to a spot as small as 20 nm in diameter. During the past five years, much effort has been devoted to a reappraisal of well known SIMS methodologies in regard to their applicability to a range of lateral resolution (20-1000 nm) previously unexplored. Furthermore, of particular concern has been the identification of research areas whose demands could most profitably be matched by the performance of this new class of microprobes. The results of this effort are contained in over 21 topical publications and 14 review articles covering both instrumental aspects of our development and applications to a variety of interdisciplinary problems.

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4

Gröner, E., and P. Hoppe. "Automated ion imaging with the NanoSIMS ion microprobe." Applied Surface Science 252, no. 19 (July 2006): 7148–51. http://dx.doi.org/10.1016/j.apsusc.2006.02.280.

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5

Bolsover, Stephen R. "Ratio imaging of intracellular ion concentration." Proceedings, annual meeting, Electron Microscopy Society of America 50, no. 2 (August 1992): 1160–61. http://dx.doi.org/10.1017/s0424820100130432.

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The field of intracellular ion concentration measurement expanded greatly in the 1980's due primarily to the development by Roger Tsien of ratiometric fluorescence dyes. These dyes have many applications, and in particular they make possible to image ion concentrations: to produce maps of the ion concentration within living cells. Ion imagers comprise a fluorescence microscope, an imaging light detector such as a video camera, and a computer system to process the fluorescence signal and display the map of ion concentration.Ion imaging can be used for two distinct purposes. In the first, the imager looks at a field of cells, measuring the mean ion concentration in each cell of the many in the field of view. One can then, for instance, challenge the cells with an agonist and examine the response of each individual cell. Ion imagers are not necessary for this sort of experiment: one can instead use a system that measures the mean ion concentration in a just one cell at any one time. However, they are very much more convenient.

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6

Collins-Fekete, Charles-Antoine, Nikolaos Dikaios, Esther Bär, and Philip M. Evans. "Statistical limitations in ion imaging." Physics in Medicine & Biology 66, no. 10 (May 10, 2021): 105009. http://dx.doi.org/10.1088/1361-6560/abee57.

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7

Odom, Robert W. "Secondary Ion Mass Spectrometry Imaging." Applied Spectroscopy Reviews 29, no. 1 (February 1994): 67–116. http://dx.doi.org/10.1080/05704929408000898.

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8

Leskiw, Brian D., Myung Hwa Kim, Gregory E. Hall, and Arthur G. Suits. "Reflectron velocity map ion imaging." Review of Scientific Instruments 76, no. 10 (October 2005): 104101. http://dx.doi.org/10.1063/1.2075167.

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9

P. Engler, R. L. Barbour, J. H. Gibson, M. S. Hazle, D. G. Cameron, and R. H. Duff. "Imaging With Spectroscopic Data." Advances in X-ray Analysis 31 (1987): 69–75. http://dx.doi.org/10.1154/s0376030800021856.

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Spectroscopic data from a var iety of analyt ical techniques such as x-ray diffraction (XRD), infrared (IR) and Raman spectroscopies, secondary ion mass spectrometry (SIMS) and energy dispersive X-ray analysis (EDX) can be obtained from small areas of samples (< 1 mm2) through the use of microscope sampling accessories. If provisions are made to scan or translate the sample, then a spectrum that is characteristic of each region of interest can be obtained. Alternatively, selective area detectors eliminate the requirement for scanning the sample. Extract ion of information about a specific energy band from each spectrum allows elucidat ion of the spatial distribution of the feature giving rise to that band. For example, the distribution of a compound could be imaged by extracting the intensity of an IR band or XRD peak due to that compound. Peak posit ion and peak width are other parameters that can be extracted as a function of posit ion. Similarly, elemental distributions could be obtained using SIMS and EDX.

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10

Hull, Robert, Derren Dunn, and Alan Kubis. "Nanoscale Tomographic Imaging using Focused Ion Beam Sputtering, Secondary Electron Imaging and Secondary Ion Mass Spectrometry." Microscopy and Microanalysis 7, S2 (August 2001): 934–35. http://dx.doi.org/10.1017/s1431927600030749.

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As the importance of nano-scaled structures in both science and engineering increases, techniques for reconstructing three-dimensional structural, crystallographic and chemical relationships become increasingly important. in this paper we described a technique which uses focused ion beam (FIB) sputtering to expose successive layers of a 3D sample, coupled with secondary electron imaging and secondary ion mass spectrometry of each sputtered surface. Computer interpolation of these different slice images then enables reconstruction of the 3D structure and chemistry of the sample. These techniques are applicable to almost any inorganic material, at a spatial resolution of tens of nanometers, and fields of view up to (tens of μm).The FIB instrument used in this study is an FEI 200 with a minimum ion probe diameter < 10 nm, an ion current density ∼ 10 A/cm2, a maximum ion current of 11 nA, and a standard Ga+ ion energy of 30 keV. Our instrument is equipped with a continuous dynode electron multiplies (CDEM) for secondary electron imaging and a quadrupole mass spectrometer for secondary ion mass spectroscopy (SIMS) / element specific mapping. Gallium ions of this energy will ablate any material, with sputter yields typically of order ten, corresponding to a material removal rate of order 1 μm3nA−1s−1.

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11

Touboul, David, Fréderic Halgand, Alain Brunelle, Reinhard Kersting, Elke Tallarek, Birgit Hagenhoff, and Olivier Laprévote. "Tissue Molecular Ion Imaging by Gold Cluster Ion Bombardment." Analytical Chemistry 76, no. 6 (March 2004): 1550–59. http://dx.doi.org/10.1021/ac035243z.

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12

Slodzian, Georges. "Ion microprobe imaging of biological samples." Proceedings, annual meeting, Electron Microscopy Society of America 50, no. 2 (August 1992): 1600–1601. http://dx.doi.org/10.1017/s0424820100132637.

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Microanalysis of biological samples by using secondary ion emission is a challenging problem because it requires high lateral resolving power, high sensitivity and high selectivity simultaneously. In this paper, the limits and the possibilities of the method will be examined regardless of the sample preparation conditions that is from a simple instrumentalist's point of view.Any mass spectrometric method is destructive which means here that a given volume of the sample has to be sputtered to produce an adequate secondary ion signal. The size of this volume depends upon the atomic concentrations, the atomic density, the useful yield and the magnitude of the desired signal. To take an example, with an useful yield of 1% it would be necessary to sputter 300 atoms M to get an average signal of 3 ions (±) related to M. Such a signal would allow to detect the presence of element M with about 95% certainty (probability of getting one ion at least).

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13

Syed, Sarfaraz U. A. H., Simon Maher, Gert B. Eijkel, Shane R. Ellis, Fred Jjunju, Stephen Taylor, and Ron M. A. Heeren. "Direct Ion Imaging Approach for Investigation of Ion Dynamics in Multipole Ion Guides." Analytical Chemistry 87, no. 7 (March 23, 2015): 3714–20. http://dx.doi.org/10.1021/ac5041764.

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14

Grimm, Casey C., R. T. Short, and Peter J. Todd. "A wide-angle secondary ion probe for organic ion imaging." Journal of the American Society for Mass Spectrometry 2, no. 5 (September 1991): 362–71. http://dx.doi.org/10.1016/1044-0305(91)85002-n.

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15

Carrascosa, Eduardo, Jennifer Meyer, and Roland Wester. "Imaging the dynamics of ion–molecule reactions." Chemical Society Reviews 46, no. 24 (2017): 7498–516. http://dx.doi.org/10.1039/c7cs00623c.

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A range of ion–molecule reactions have been studied in the last years using the crossed-beam ion imaging technique, from charge transfer and proton transfer to nucleophilic substitution and elimination.

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16

Li, Wen, Steven D. Chambreau, Sridhar A. Lahankar, and Arthur G. Suits. "Megapixel ion imaging with standard video." Review of Scientific Instruments 76, no. 6 (June 2005): 063106. http://dx.doi.org/10.1063/1.1921671.

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17

Mesa Sanchez, Daniela, Steve Creger, Veerupaksh Singla, Ruwan T. Kurulugama, John Fjeldsted, and Julia Laskin. "Ion Mobility-Mass Spectrometry Imaging Workflow." Journal of the American Society for Mass Spectrometry 31, no. 12 (August 4, 2020): 2437–42. http://dx.doi.org/10.1021/jasms.0c00142.

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18

Yamamura, Hisao. "Imaging analyses of ion channel_molecule functions." Folia Pharmacologica Japonica 142, no. 2 (2013): 79–84. http://dx.doi.org/10.1254/fpj.142.79.

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19

Breese, M. B. H., P. J. C. King, J. Whitehurst, G. R. Booker, G. W. Grime, F. Watt, L. T. Romano, and E. H. C. Parker. "Dislocation imaging using transmission ion channeling." Journal of Applied Physics 73, no. 6 (March 15, 1993): 2640–53. http://dx.doi.org/10.1063/1.353081.

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20

Burker, Alexander, Thomas Bergauer, Albert Hirtl, Christian Irmler, Stefanie Kaser, Peter Paulitsch, Vera Teufelhart, Felix Ulrich-Pur, and Manfred Valentan. "Imaging with Ion Beams at MedAustron." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 958 (April 2020): 162246. http://dx.doi.org/10.1016/j.nima.2019.05.087.

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21

Barroo, Cédric, and Thierry Visart de Bocarmé. "Imaging Graphene by Field Ion Microscopy." Microscopy and Microanalysis 22, S3 (July 2016): 1542–43. http://dx.doi.org/10.1017/s1431927616008552.

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22

Hepler, Peter K., and Dale A. Callaham. "Calcium ion imaging in plant cells." Proceedings, annual meeting, Electron Microscopy Society of America 51 (August 1, 1993): 132–33. http://dx.doi.org/10.1017/s0424820100146503.

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Calcium ions (Ca) participate in many signal transduction processes, and for that reason it is important to determine where these ions are located within the living cell, and when and to what extent they change their local concentration. Of the different Ca-specific indicators, the fluorescent dyes, developed by Grynkiewicz et al. (1), have proved most efficacious, however, their use on plants has met with several problems (2). First, the dyes as acetoxy-methyl esters are often cleaved by extracellular esterases in the plant cell wall, and thus they do not enter the cell. Second, if the dye crosses the plasma membrane it may continue into non-cytoplasmic membrane compartments. Third, even if cleaved by esterases in the cytoplasm, or introduced as the free acid into the cytoplasmic compartment, the dyes often become quickly sequestered into vacuoles and organelles, or extruded from the cell. Finally, the free acid form of the dye readily complexes with proteins reducing its ability to detect free calcium. All these problems lead to an erroneous measurement of calcium (2).

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23

Wu, Huimeng, Sybren Sijbrandij, Shawn McVey, and John Notte. "Imaging Contrast with Multiple Ion Beams." Microscopy and Microanalysis 21, S3 (August 2015): 345–46. http://dx.doi.org/10.1017/s1431927615002524.

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24

Wu, Huimeng, Sybren Sijbrandij, Shawn McVey, and John Notte. "Imaging Contrast with Multiple Ion Beams." Microscopy and Microanalysis 21, S3 (August 2015): 701–2. http://dx.doi.org/10.1017/s1431927615004304.

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25

Norarat, R., V. Marjomäki, X. Chen, M. Zhaohong, R. Minqin, C. B. Chen, A. A. Bettiol, H. J. Whitlow, and F. Watt. "Ion-induced fluorescence imaging of endosomes." Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 306 (July 2013): 113–16. http://dx.doi.org/10.1016/j.nimb.2012.12.052.

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26

Huang, Cunshun, Wen Li, Myung Hwa Kim, and Arthur G. Suits. "Two-color reduced-Doppler ion imaging." Journal of Chemical Physics 125, no. 12 (September 28, 2006): 121101. http://dx.doi.org/10.1063/1.2353814.

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27

Huang, Cunshun, Sridhar A. Lahankar, Myung Hwa Kim, Bailin Zhang, and Arthur G. Suits. "Doppler-free/Doppler-sliced ion imaging." Physical Chemistry Chemical Physics 8, no. 40 (2006): 4652. http://dx.doi.org/10.1039/b612324d.

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28

Climen, B., B. Concina, M. A. Lebeault, F. Lépine, B. Baguenard, and C. Bordas. "Ion-imaging study of C60 fragmentation." Chemical Physics Letters 437, no. 1-3 (March 2007): 17–22. http://dx.doi.org/10.1016/j.cplett.2007.02.014.

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29

Forbes, Richard G. "Field-ion imaging old and new." Applied Surface Science 94-95 (March 1996): 1–16. http://dx.doi.org/10.1016/0169-4332(95)00516-1.

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30

Burnett, Paul, Janet K. Robertson, Jeffrey M. Palmer, Richard R. Ryan, Adrienne E. Dubin, and Robert A. Zivin. "Fluorescence Imaging of Electrically Stimulated Cells." Journal of Biomolecular Screening 8, no. 6 (December 2003): 660–67. http://dx.doi.org/10.1177/1087057103258546.

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Designing high-throughput screens for voltage-gated ion channels has been a tremendous challenge for the pharmaceutical industry because channel activity is dependent on the transmembrane voltage gradient, a stimulus unlike ligand binding to G-protein-coupled receptors or ligand-gated ion channels. To achieve an acceptable throughput, assays to screen for voltage-gated ion channel modulators that are employed today rely on pharmacological intervention to activate these channels. These interventions can introduce artifacts. Ideally, a high-throughput screen should not compromise physiological relevance. Hence, a more appropriate method would activate voltage-gated ion channels by altering plasma membrane potential directly, via electrical stimulation, while simultaneously recordingthe operation of the channel in populations of cells. The authors present preliminary results obtained from a device that is designed to supply precise and reproducible electrical stimuli to populations of cells. Changes in voltage-gated ion channel activity were monitored using a digital fluorescent microscope. The prototype electric field stimulation (EFS) device provided real-time analysis of cellular responsiveness to physiological and pharmacological stimuli. Voltage stimuli applied to SK-N-SH neuroblastoma cells cultured on the EFS device evoked membrane potential changes that were dependent on activation of voltage-gated sodium channels. Data obtained using digital fluorescence microscopy suggests suitability of this system for HTS.

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31

McMahon, G., and L. J. Cabri. "SIMS direct ion imaging in the mineralogical sciences." Proceedings, annual meeting, Electron Microscopy Society of America 54 (August 11, 1996): 698–99. http://dx.doi.org/10.1017/s0424820100165951.

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The use of secondary ion mass spectrometry (SIMS) has enjoyed increasing popularity in the mineralogical sciences owing to its high sensitivity to all elements in the periodic table with detection limits in the parts per million to parts per billion regime, coupled with the ability to display maps of elemental distribution at these detection levels with a spatial resolution of 1 μm. A description of the technique and its application to a wide variety of mineralogical problems has recently been reviewed.The drawback of SIMS is the rather complicated nature of quantification schemes necessitated by sample matrix effects, which refer to differences in the sensitivity for a given element in samples of different composition. These differences result from changes in the ionization efficiency and sputtering yield (sample matrix specific) as well as changes in secondary ion transmission and ion collection efficiencies (instrument specific). Therefore, the use of matrix-matched standards of known concentration is required to establish a calibration factor known as the relative sensitivity factor (RSF) which can be used to convert the experimentally measured secondary ion intensity into concentration values. Furthermore, the effect of changes in ion intensity caused by variations in primary beam current or analysis at different sample positions is removed by normalization to an ion species which represents the matrix material.

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32

Shu, Gang, Chen-Kuan Chou, Nathan Kurz, Matthew R. Dietrich, and Boris B. Blinov. "Efficient fluorescence collection and ion imaging with the “tack” ion trap." Journal of the Optical Society of America B 28, no. 12 (November 11, 2011): 2865. http://dx.doi.org/10.1364/josab.28.002865.

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33

Rohrbach, Petra. "Imaging ion flux and ion homeostasis in blood stage malaria parasites." Biotechnology Journal 4, no. 6 (June 2009): 812–25. http://dx.doi.org/10.1002/biot.200900084.

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34

Brown, J. D., and W. Vandervorst. "Scanning ion imaging as a diagnostic tool for an ion microscope." Surface and Interface Analysis 7, no. 2 (April 1985): 74–78. http://dx.doi.org/10.1002/sia.740070204.

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35

Bell, David C. "Contrast Mechanisms and Image Formation in Helium Ion Microscopy." Microscopy and Microanalysis 15, no. 2 (March 16, 2009): 147–53. http://dx.doi.org/10.1017/s1431927609090138.

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AbstractThe helium ion microscope is a unique imaging instrument. Based on an atomic level imaging system using the principle of field ion microscopy, the helium ion source has been shown to be incredibly stable and reliable, itself a remarkable engineering feat. Here we show that the image contrast is fundamentally different to other microscopes such as the scanning electron microscope (SEM), although showing many operational similarities due to the physical ion interaction mechanisms with the sample. Secondary electron images show enhanced surface contrast due the small surface interaction volume as well as elemental contrast differences, such as for nanowires imaged on a substrate. We present images of nanowires and nanoparticles for comparison with SEM imaging. Applications of Rutherford backscattered ion imaging as a unique and novel imaging mechanism are described. The advantages of the contrast mechanisms offered by this instrument for imaging nanomaterials are clearly apparent due to the high resolution and surface sensitivity afforded in the images. Future developments of the helium ion microscope should yield yet further improvements in imaging and provide a platform for continued advances in microscope science and nanoscale research.

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36

Radici, Marco. "Electron Ion Collider: 3D-Imaging the Nucleon." EPJ Web of Conferences 182 (2018): 02062. http://dx.doi.org/10.1051/epjconf/201818202062.

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The Electron Ion Collider (EIC) is the project for a new US-based, high-energy, high-luminosity facility, capable of a versatile range of beam energies, polarizations, and ion species. Its primary goal is to precisely image quarks and gluons and their interactions inside hadrons, in order to investigate their confined dynamics and elucidate how visible matter is made at its most fundamental level. I will introduce the main physics questions addressed by such a facility, and give some more details on the topic of Transverse Momentum Dependent parton distributions (TMDs).

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37

Radici, Marco. "Electron Ion Collider: 3D-Imaging the Nucleon." EPJ Web of Conferences 182 (2018): 02103. http://dx.doi.org/10.1051/epjconf/201818202103.

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The Electron Ion Collider (EIC) is the project for a new US-based, high-energy, high-luminosity facility, capable of a versatile range of beam energies, polarizations, and ion species. Its primary goal is to precisely image quarks and gluons and their interactions inside hadrons, in order to investigate their confined dynamics and elucidate how visible matter is made at its most fundamental level. I will introduce the main physics questions addressed by such a facility, and give some more details on the topic of Transverse Momentum Dependent parton distributions (TMDs).

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38

Wirtz, Tom, Olivier De Castro, Jean-Nicolas Audinot, and Patrick Philipp. "Imaging and Analytics on the Helium Ion Microscope." Annual Review of Analytical Chemistry 12, no. 1 (June 12, 2019): 523–43. http://dx.doi.org/10.1146/annurev-anchem-061318-115457.

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The helium ion microscope (HIM) has emerged as an instrument of choice for patterning, imaging and, more recently, analytics at the nanoscale. Here, we review secondary electron imaging on the HIM and the various methodologies and hardware components that have been developed to confer analytical capabilities to the HIM. Secondary electron–based imaging can be performed at resolutions down to 0.5 nm with high contrast, with high depth of field, and directly on insulating samples. Analytical methods include secondary electron hyperspectral imaging (SEHI), scanning transmission ion microscopy (STIM), backscattering spectrometry and, in particular, secondary ion mass spectrometry (SIMS). The SIMS system that was specifically designed for the HIM allows the detection of all elements, the differentiation between isotopes, and the detection of trace elements. It provides mass spectra, depth profiles, and 2D or 3D images with lateral resolutions down to 10 nm.

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39

Pachuta, Steven J. "Industrial applications of TOF-SIMS imaging." Proceedings, annual meeting, Electron Microscopy Society of America 54 (August 11, 1996): 1040–41. http://dx.doi.org/10.1017/s0424820100167664.

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Time-of-flight secondary ion mass spectrometry (TOF-SIMS) has in recent years become a useful tool for surface analysis in industrial laboratories. All elements and isotopes, as well as many molecular entities, can be detected by SIMS, with most of the signal coming from the outer 10 - 20 Å of the surface. The initial penetration of TOF-SIMS into industry was as an improvement over existing quadrupole instruments, with higher mass range, mass resolution, and sensitivity. The coupling of TOF-SIMS with high brightness liquid metal ion sources greatly expanded the applicability of the technique, making chemical imaging of the outermost monolayers of a surface a routine experiment.Several examples will be presented of TOF-SIMS imaging applied to real-world materials encountered in an industrial analytical laboratory. All results were obtained from a PHI-Evans TFS series instrument equipped with an FEI two-lens 69Ga+ liquid metal ion gun (LMIG). When operated at 25 keV beam energy, a primary ion beam diameter of 2500 Å in continuous mode, and 1-2 μm in pulsed mode, can routinely be obtained.

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40

Jackson, Shelley N., Damon Barbacci, Thomas Egan, Ernest K. Lewis, J. Albert Schultz, and Amina S. Woods. "MALDI-ion mobility mass spectrometry of lipids in negative ion mode." Anal. Methods 6, no. 14 (2014): 5001–7. http://dx.doi.org/10.1039/c4ay00320a.

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41

Chandra, Subhash. "Imaging transported and endogenous calcium independently at a subcellular resolution: ion microscopy imaging of calcium stable isotopes." Proceedings, annual meeting, Electron Microscopy Society of America 50, no. 2 (August 1992): 1604–5. http://dx.doi.org/10.1017/s0424820100132650.

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Ion microscopy, based on secondary ion mass spectrometry (SIMS), is a unique isotopic imaging technique. The use of stable isotopes as tracers and their SIMS localization at a subcellular resolution has introduced a significant new approach for molecular localization and ion transport studies. A molecule of interest may be tagged with stable 2H, 13C, 15N, etc. and imaged with SIMS for its intracellular location. Stable isotopes of physiologically important elements such as calcium and magnesium provide excellent tracers for ion transport imaging studies with SIMS. in a recent study with 44Ca, the brush border region in the small intestine was observed to be the main barrier for calcium transport from the intestinal lumen to the lamina propria region in chickens suffering from Rickets, a vitamin D-deficiency condition.An example of the use of 44Ca stable isotope for imaging calcium-calcium exchange between the intracellular and extracellular calcium with SIMS is shown in figure 1. 3T3 cells were grown on high purity germanium chips to about 80% confluency.

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42

Gebhardt, Christoph R., T. Peter Rakitzis, Peter C. Samartzis, Vlassis Ladopoulos, and Theofanis N. Kitsopoulos. "Slice imaging: A new approach to ion imaging and velocity mapping." Review of Scientific Instruments 72, no. 10 (October 2001): 3848–53. http://dx.doi.org/10.1063/1.1403010.

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43

McLean, John A., Whitney B. Ridenour, and Richard M. Caprioli. "Profiling and imaging of tissues by imaging ion mobility-mass spectrometry." Journal of Mass Spectrometry 42, no. 8 (2007): 1099–105. http://dx.doi.org/10.1002/jms.1254.

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44

Liu, Candace C., Erin F. McCaffrey, Noah F. Greenwald, Erin Soon, Tyler Risom, Kausalia Vijayaragavan, John-Paul Oliveria, et al. "Multiplexed Ion Beam Imaging: Insights into Pathobiology." Annual Review of Pathology: Mechanisms of Disease 17, no. 1 (January 24, 2022): 403–23. http://dx.doi.org/10.1146/annurev-pathmechdis-030321-091459.

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Next-generation tools for multiplexed imaging have driven a new wave of innovation in understanding how single-cell function and tissue structure are interrelated. In previous work, we developed multiplexed ion beam imaging by time of flight, a highly multiplexed platform that uses secondary ion mass spectrometry to image dozens of antibodies tagged with metal reporters. As instrument throughput has increased, the breadth and depth of imaging data have increased as well. To extract meaningful information from these data, we have developed tools for cell identification, cell classification, and spatial analysis. In this review, we discuss these tools and provide examples of their application in various contexts, including ductal carcinoma in situ, tuberculosis, and Alzheimer's disease. We hope the synergy between multiplexed imaging and automated image analysis will drive a new era in anatomic pathology and personalized medicine wherein quantitative spatial signatures are used routinely for more accurate diagnosis, prognosis, and therapeutic selection.

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45

Joy, D. C., and J. R. Michael. "Modeling ion-solid interactions for imaging applications." MRS Bulletin 39, no. 4 (April 2014): 342–46. http://dx.doi.org/10.1557/mrs.2014.57.

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46

Ide, T., H. Sakamoto, and T. Yanagida. "Single molecule imaging of an ion-channel." Seibutsu Butsuri 40, supplement (2000): S205. http://dx.doi.org/10.2142/biophys.40.s205_4.

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47

Fletcher, John S. "Cellular imaging with secondary ion mass spectrometry." Analyst 134, no. 11 (2009): 2204. http://dx.doi.org/10.1039/b913575h.

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Breese, M. B. H., P. J. C. King, G. W. Grime, and P. R. Wilshaw. "Dislocation imaging using ion beam induced charge." Applied Physics Letters 62, no. 25 (June 21, 1993): 3309–11. http://dx.doi.org/10.1063/1.109055.

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Samartzis, Peter C., Ioannis Sakellariou, Theodosia Gougousi, and Theofanis N. Kitsopoulos. "Photofragmentation study of Cl2 using ion imaging." Journal of Chemical Physics 107, no. 1 (July 1997): 43–48. http://dx.doi.org/10.1063/1.474389.

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Wester, Roland. "Velocity map imaging of ion–molecule reactions." Phys. Chem. Chem. Phys. 16, no. 2 (2014): 396–405. http://dx.doi.org/10.1039/c3cp53405g.

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