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Dissertations / Theses on the topic 'Ion imaging'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Rogers, Leon John. "Photofragment ion imaging." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266958.

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2

Yuen, Wei Hao. "Ion imaging mass spectrometry." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564395.

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This work investigates the applicability of fast detectors to the technique of microscope-mode imaging mass spectrometry. By ionising analyte from a large area of the sample, and projecting the desorbed ions by the use of ion optics through a time-of-flight mass spectrometer onto a two- dimensional detector, time- (and hence mass-) dependent distributions of ions may be imaged. To date, this method of imaging mass spectrometry has been limited by the ability to image only one mass window of interest per experimental cycle, limiting throughput and processing speed. Thus, the alternative micropr

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3

Johnsen, Alexander. "Ion Imaging, applications and extensions." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533852.

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4

Beckert, Marco. "Photodissociation dynamics of halogens and halogen-ions studied by ion imaging." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274674.

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5

King, Philip J. C. "Crystal defect imaging using transmission ion channelling." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358679.

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6

Rivas, Charlotte. "Dual-modal imaging agents for zinc ion sensing." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/30814.

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The area of MRI/optical imaging has received a lot of attention as their combination brings together the high spatial resolution of MRI with the high sensitivity of optical imaging. Changes in pancreatic β-cell mass contribute to the development of both type 1 and type 2 diabetes. Whilst the processes of β-cell loss are fairly well established for type 1, both the extent of the loss and the underlying mechanisms are relatively unknown for type 2. Zinc ions are highly concentrated in the insulin granules that are contained within β-cells. Few robust approaches currently exist to monitor changes

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7

Nakata, Yoshihiko. "Imaging Mass Spectrometry with MeV Heavy Ion Beams." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124537.

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8

Kogovsek, Laurie Maylish. "Magnetic resonance imaging of elastomers and ion exchange resins." Case Western Reserve University School of Graduate Studies / OhioLINK, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=case1057869238.

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9

Monti, Oliver A. L. "Crossing thresholds : Rydberg-tagging and near-threshold photodissociation." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365747.

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10

Cooper, Martin James. "Spectroscopy and photodissociation dynamics of diatomic molecules." Thesis, University of Bristol, 1998. http://hdl.handle.net/1983/b6fb7599-b7a3-4e6d-9945-7b59e6204496.

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11

Blums, Valdis Roberts. "Ion Fluorescence Collection And Diffraction Limited Imaging From A Microfabricated Ion Trap With Integrated Diffractive Mirrors." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/365461.

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In this thesis I discuss the collaborative monolithic design and testing of microfabricated diffractive mirrors integrated into a microfabricated ion trap. I discuss the necessary optical and electrical systems needed to trap 174Yb+ ions. From the diffractive mirrors we measured a collection efficiency of more than 4% per ion fluorescence photon, while obtaining diffraction limited ion images.<br>Thesis (Masters)<br>Master of Philosophy (MPhil)<br>School of Natural Sciences<br>Science, Environment, Engineering and Technology<br>Full Text

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12

Freeman, Stewart Peter Hans Thielbeer. "The radiocarbon microprobe : an imaging secondary ion accelerator mass spectrometer." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314932.

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13

Panday, Namuna. "Scanning Ion Conductance Microscopy for Single Cell Imaging and Analysis." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3477.

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Most biological experiments are performed on an ensemble of cells under the assumption that all cells are identical. However, recent evidence from single cells studies reveals that this assumption is incorrect. Individual cells within the same generation may differ dramatically, and these differences have important consequences for the health and function of the entire living body. I have used Scanning Ion Conductance Microscopy (SICM) for imaging and analysis of topographical change of single cell membrane, which is difficult to be revealed by optical microscopes. Morphological change in the

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14

Winchell, Stephen D. "Transport imaging in the one dimensional limit." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2006. http://library.nps.navy.mil/uhtbin/hyperion/06Jun%5FWinchell.pdf.

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15

Calvi, Ryan M. D. "Negative ion photoelectron imaging spectroscopy of iodine monobromide and copper hydrides." Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1446093.

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16

Besztejan, Stephanie [Verfasser], and Andrea [Akademischer Betreuer] Rentmeister. "Metal Ion Based Probes for Imaging / Stephanie Besztejan. Betreuer: Andrea Rentmeister." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1111039119/34.

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17

Milgrew, Mark James. "An integrated CMOS sensor array technology for direct extracellular ion imaging." Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528663.

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18

Sage, Alan Graham. "Velocity mapped ion imaging studies of substituted aromatic and heteroaromatic molecules." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529835.

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19

Besztejan, Stephanie Verfasser], and Andrea [Akademischer Betreuer] [Rentmeister. "Metal Ion Based Probes for Imaging / Stephanie Besztejan. Betreuer: Andrea Rentmeister." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://nbn-resolving.de/urn:nbn:de:gbv:18-79705.

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20

Neugebohren, Jannis. "Implementing Ion Imaging to Probe Chemical Kinetics and Dynamics at Surfaces." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://hdl.handle.net/11858/00-1735-0000-002E-E43B-1.

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21

Guo, Ang. "Improving the performance of microscope mass spectrometry imaging." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:aa94a7f6-00ee-4b56-ba65-f6946799d5f2.

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Mass spectrometry imaging (MSI) is a powerful tool that provides mass-specific surface images with micron or sub-micron spatial resolutions. In a microscope MSI experiment, large sample surfaces are illuminated with a defocused laser or primary ion beam, enabling all surface molecules to be desorbed and ionised simultaneously before being electrostatically projected onto a position-sensitive imaging detector at the end of a time-of-flight mass analyser. Traditionally only the image of one mass-to-charge ratio can be obtained in a single acquisition, which limits its applicability. However, the

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22

Howie, Wendy Helen. "Molecular structure and predissociation dynamics studied using absorption spectroscopy and ion imaging." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364886.

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23

Finegan, D. P. "X-ray imaging of failure and degradation mechanisms of lithium-ion batteries." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1534606/.

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Lithium-ion batteries are becoming increasingly energy and power dense, and are required to operate in demanding applications and under challenging conditions. Both safety and performance of lithium-ion batteries need to be improved to meet the needs of the current demand, and are inextricably linked to their microstructure and mechanical design. However, there is little understanding of the complex, multi-length scale, structural dynamics that occur inside cells during operation and failure. From the evolving particle microstructure during operation to the rapid breakdown of active materials

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24

Winter, Benjamin. "Novel methods in imaging mass spectrometry and ion time-of-flight detection." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:43db5039-0490-4f97-8519-4d3ed4e30ca3.

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Imaging mass spectrometry (IMS) in microscope mode allows the spatially resolved molecular constitution of a large sample section to be analysed in a single experiment. If performed in a linear mass spectrometer, the applicability of microscope IMS is limited by a number of factors: the low mass resolving power of the employed ion optics; the time resolution afforded by the scintillator screen based particle detector and the multi-hit capability, per pixel, of the employed imaging sensor. To overcome these limitations, this thesis concerns the construction of an advanced ion optic employing a

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25

Price, Roosevelt Jerome. "Photodissociation studies with vacuum ultraviolet lasers by means of ion velocity imaging /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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26

Berrueta, Razo Irma. "Molecular imaging of mouse brain tissue using Cluster Time-of-Flight Secondary Ion Mass Spectrometry." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/molecular-imaging-of-mouse-brain-tissue-using-cluster-timeofflight-secondary-ion-mass-spectrometry(a350dc50-5337-4d32-a95c-24c617bbba97).html.

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ToF-SIMS imaging has been drawing attention due to the wide range of applications in the biological and biomedical fields. These applications include the acquisition of quantitative and qualitative data that ranges in scale from single cells to organs, image visualisation and interpretation of biomarkers for diagnosis and development of pharmaceutics. This study focused on molecular imaging of mouse brain tissue sections using cluster primary ion beams. First, cluster ion beams were applied to comparative background studies of biomolecules and brain total lipid extract. Enhancement of the seco

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27

Norton, Benjamin Geoffrey. "High Resolution Imaging of Single Trapped Yb+ Ions Using A Phase Fresnel Lens." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/366427.

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The thesis describes the use of a high numerical aperture phase Fresnel lens for high resolution ion imaging and scalable fluorescence collection. We have demonstrated the first step towards fabricating and integrating a scalable collection optic with an ion trap with applications towards large scale ion trap quantum computers. I outline the use of the lens for capturing high resolution images of trapped ions. Using these high resolution images we have demonstrated spatial thermometry, a thermometry technique which relies on imaging the small changes in the ion spot size as the ion temperatur

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28

Warner, Joshua Dale. "Kidney segmentat ion and image analysis in autosomal dominant polycystic kidney disease." Thesis, College of Medicine - Mayo Clinic, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10111486.

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<p> Autosomal Dominant Polycystic Kidney Disease (ADPKD) is among the most prevalent life-threatening genetic conditions. Despite this, no approved medical therapies exist to treat the disease. Until the recent past, no methods could reliably measure the course of the disease far in advance of end stage renal disease (ESRD). As normal tissue is progressively destroyed or blocked by enlarging cysts, remaining nephrons compensate in a process called hyperfiltration. This beneficial physiological response confounds tests of renal function. Thus, potential interventions could not be tested against

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29

Stephenson, David E. "Microstructure and Transport Properties of Porous Li-ion Electrodes." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2752.

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The goal of this work is to understand the relationships between electrode microstructure and mass transport resistances. One can use this information to predict cell performance from fundamental principles. This work includes new types of particle-scale 3D models for correlating and predicting the effects of electrode microstructure on both ionic and electronic transport. The 3D models imitate the sub-micrometer-scale arrangement of active material particles, carbon, binder, and pores and use FIB/SEM images as a basis for parameterization. The 3D models are based respectively on the statistic

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30

Maharjan, Chakra Man. "Momentum imaging studies of electron and ion dynamics in a strong laser field." Diss., Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/378.

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31

Brahmi, Chloé. "Study of scleractinian coral biomineralization using ⁸⁶Sr-labeling and NanoSIMS ion-microprobe imaging." Paris, Muséum national d'histoire naturelle, 2012. http://www.theses.fr/2012MNHN0042.

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Les coraux Scléractiniaires produisent un exosquelette en carbonate de calcium (aragonite). Leurs processus de biominéralisation ont été étudiés chez trois espèces présentant différents taux de croissance et vivant ou non en symbiose avec les zooxanthelles. Une hétérogénéité de composition du tissu et du squelette a été mise en évidence, à différentes échelles, via des techniques d’observations et de micro-analyses, à haute résolution spatiale. Un thème central a été le développement et l’application d’une méthode de marquage de biocarbonates marins basée sur un enrichissement avec un isotope

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32

Villacob, Raul A. "Development of a Primary Ion Column for Mass Spectrometry-Based Surface Analysis." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2561.

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Secondary Ion Mass Spectrometry (SIMS) is a powerful technique for high spatial resolution chemical mapping and characterization of native surfaces. The use of massive cluster projectiles has been shown to extend the applicable mass range of SIMS and improve secondary ion yields 100 fold or beyond. These large projectiles however, present a challenge in terms of focusing due to the initial spatial and kinetic energy spreads inherent to their generation. In the present work, we describe the development and construction of a novel primary ion (PI) column employing a gold nanoparticle – liquid me

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33

Uhlén, Per. "Signal transduction via ion fluxes : a cell imaging study with emphasis on calcium oscillations /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-188-8.

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34

Richard, Marie-Hélène. "Design study of a Compton camera for prompts-gamma imaging during ion beam therapy." Phd thesis, Université Claude Bernard - Lyon I, 2012. http://tel.archives-ouvertes.fr/tel-00934715.

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Ion beam therapy is an innovative radiotherapy technique using mainly carbon ion and proton irradiations. Its aim is to improve the current treatment modalities. Because of the sharpness of the dose distributions, a control of the dose if possible in real time is highly desirable. A possibility is to detect the prompt gamma rays emitted subsequently to the nuclear fragmentations occurring during the treatment of the patient. In a first time two different Compton cameras (double and single scattering) have been optimised by means of Monte Carlo simulations. The response of the camera to a photo

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35

Rinaldi, Ilaria [Verfasser], and Katia [Akademischer Betreuer] Parodi. "Investigation of novel imaging methods using therapeutic ion beams / Ilaria Rinaldi ; Betreuer: Katia Parodi." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/1179230353/34.

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36

Iskra, Andreas. "Photofragmentation studies of metal ion-molecule complexes and metal oxides." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:d3663b37-7954-47a3-83e3-4a9ad7b9e3e7.

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Gas phase metal-containing complexes provide suitable systems in which to study fundamental binding motifs between a metal ion and molecules in the absence of any solvent, support or competing charge effects. In this thesis, metal-containing species are explored experimentally using infrared resonance enhanced photodissociation (IR-REPD) spectroscopy and velocity map imaging (VMI). The experimental results are further interpreted with the aid of spectral simulations based on density functional theory (DFT). These are the first studies reported using a newly built IR-REPD spectrometer equipped

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37

Clarson, Benjamin B. "Spectroscopic and ion imaging studies of the Rydberg states of NO in homogenous electric fields." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496838.

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38

Domesle, Christian [Verfasser], and Andreas [Akademischer Betreuer] Wolf. "Momentum Imaging of Photofragments and Photoelectrons using Fast Ion Beams / Christian Domesle ; Betreuer: Andreas Wolf." Heidelberg : Universitätsbibliothek Heidelberg, 2012. http://d-nb.info/117978605X/34.

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39

Jiang, Haibo. "Exploiting stable isotope imaging with high resolution secondary ion mass spectrometry for applications in biology." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:15456362-6022-41e1-b78d-1127d6d172b0.

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This thesis presents applications of high resolution secondary ion mass spectrometry (NanoSIMS) analysis for stable isotope imaging in biological samples. These projects were designed to explore the potential applications of NanoSIMS analysis, and to develop protocols and novel methodologies to visualize and quantify biological processes. Working with collaborators in the UK and USA, I have applied NanoSIMS analysis to study 3 research areas, including molecule interactions, single cell metabolisms and lipid imaging in tissues. Antimicrobial peptides (AMPs) play important role in the immune sy

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40

Van, Nuffel Sebastiaan. "Three-dimensional time-of-flight secondary ion mass spectrometry imaging of primary neuronal cell cultures." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/39644/.

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Time-of-flight secondary ion mass spectrometry (ToF-SIMS) has proven its ability to characterise (in)organic surfaces, and is increasingly used for the characterisation of biological samples such as single cells. By combining ion imaging and molecular depth profiling it is possible to render 3D chemical images, which provides a novel, label-free way to investigate biological systems. Major challenges lie, however, in the development of data analysis tools and protocols that preserve the cell morphology. Here, we develop and employ such tools and protocols for the investigation of neuronal netw

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41

Sandvold, Marianne. "Technical Aspects of Ion Milling and Electron Imaging of Epoxy Embedded Samples for FIB/SEM Tomography." Thesis, Norges Teknisk-Naturvitenskaplige Universitet, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-20916.

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FIB/SEM tomography is a relatively new imaging technique for 3D investigation of biological tissue. It uses a dualbeam FIB/SEM instrument to alternately image a sample surface with an electron beam and mill off successive slices with an ion beam, collecting a series of images representing the investigated volume. This technique was employed to study alumina nanoparticles, brain tissue and tissue engineered cartilage embedded in epoxy. Hydrocarbon deposition of contamination layers as well as suboptimal sample geometry, were shown to be issues for imaging experiments. It was important to ensure

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42

Giesecke, Marianne. "Characterizing ions in solution by NMR methods." Doctoral thesis, KTH, Tillämpad fysikalisk kemi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-149552.

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NMR experiments performed under the effect of electric fields, either continuous or pulsed, can provide quantitative parameters related to ion association and ion transport in solution. Electrophoretic NMR (eNMR) is based on a diffusion pulse-sequence with electric fields applied in the form of pulses. Magnetic field gradients enable the measurement of the electrophoretic mobility of charged species, a parameter that can be related to ionic association. The effective charge of the tetramethylammonium cation ion in water, dimethylsulphoxide (DMSO), acetonitrile, methanol and ethanol was estima

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43

Venugopal, Vinithra. "Kinetics of Ion Transport in Conducting Polymers." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1458229667.

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44

Ahuja, Punkaj N. "Optode-bead-based Functional Chemical Imaging of 2D Substrates." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1307727754.

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45

Zimmerer, Cordelia. "Entwicklung eines optischen markierungsfreien Ionenkanalsensor-Arrays." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1193247156004-79633.

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Ligandgesteuerte Ionenkanäle sind Membranproteine, die an der Weiterleitung von Reizen und an der Kommunikation zwischen Zellen beteiligt sind. Große Bedeutung besitzt die Messung der Aktivierung der Ionenkanäle beispielsweise in der Medizin (z.B. Ionenkanalerkrankungen), der Pharmazie (z.B. Medikamenten-Screening) und in der Bionanotechnologie (z.B. molekulare Schalter). In all diesen Gebieten besteht die Forderung nach hohen Probendurchsätzen bei sehr hohem Informationsgehalt. Etablierte elektrochemische Detektionsmethoden erfüllen diese Forderung nicht. Um dieses Defizit zu überwinden, wurd

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46

Walton, Barbara Lynn. "A Study of Silver: an Alternative Maldi Matrix for Low Weight Compounds and Mass Spectrometry Imaging." Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc499981/.

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Soft-landing ion mobility has applicability in a variety of areas. The ability to produce material and collect a sufficient amount for further analysis and applications is the key goal of this technique. Soft-landing ion mobility has provided a way to deposit material in a controllable fashion, and can be tailored to specific applications. Changing the conditions at which soft-landing ion mobility occurs effects the characteristics of the resulting particles (size, distribution/coverage on the surface). Longer deposition times generated more material on the surface; however, higher pressur

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47

Ghous, Abid Petroleum Engineering Faculty of Engineering UNSW. "3D imaging and modeling of carbonate core at multiple scales." Awarded By:University of New South Wales. Petroleum Engineering, 2010. http://handle.unsw.edu.au/1959.4/44606.

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The understanding of multiphase flow properties is essential for the exploitation of hydrocarbon reserves in a reservoir; these properties in turn are dependent on the geometric properties and connectivity of the pore space. The determination of the pore size distribution in carbonate reservoirs remains challenging; carbonates exhibit complex pore structures comprising length scales from nanometers to several centimeters. A major challenge to the accurate evaluation of these reservoirs is accounting for pore scale heterogeneity on multiple scales. This is the topic of this thesis. Conventiona

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48

Castro, Olivier de. "Development of a Versatile High-Brightness Electron Impact Ion Source for Nano-Machining, Nano-Imaging and Nano-Analysis." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS468/document.

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Les nano-applications utilisant des faisceaux d'ions focalisés nécessitent des sources d'ions à haute brillance avec une faible dispersion en énergie (ΔE) ce qui permet une excellente résolution latérale et un courant d'ions suffisamment élevé pour induire des vitesses d'érosion raisonnables et des rendements élevés d'émission électronique et ionique. Les objectifs de cette thèse sont le développement d'une source d'ions basée sur l'impact électronique ayant une brillance réduite Br de 10³ – 10⁴ A m⁻² sr ⁻ ¹ V⁻ ¹, une dispersion en énergie ΔE ≲ 1 eV et un choix polyvalent d'ions. Le premier co

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49

Schiller, Michael [Verfasser], and Karl-Heinz [Akademischer Betreuer] Gericke. "3D Ion Imaging: Elektronische Struktur, Zerfallsdynamik und Anisotropie der Photodissoziation von DCl / Michael Schiller ; Betreuer: Karl-Heinz Gericke." Braunschweig : Technische Universität Braunschweig, 2017. http://d-nb.info/1175817066/34.

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50

Chen, Yuxiu. "Manipulation and imaging of interactions between layer-by-layer capsules and live cells using nanopipettes and SICM." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/54023.

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Usability of many chemical substances with significant potential for biomedical applications is limited by their poor solubility in water or limited stability in the physiological environment. One of promising strategies for therapeutic targeted delivery of these types of substances into cells and tissues is their encapsulation inside polyelectrolyte microcapsules (Volodkin et al., 2004b, Sukhorukov et al., 1998b). Successful internalisation of microcapsules loaded with various macromolecules have been observed in several types of living cells (Javier et al., 2008, Kastl et al., 2013), however

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