Journal articles: 'Intrinsic capacity'

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Yang, Shengtian, Rui Xu, Jun Chen, and Jian-Kang Zhang. "Intrinsic Capacity." IEEE Transactions on Information Theory 65, no. 3 (March 2019): 1345–60. http://dx.doi.org/10.1109/tit.2018.2885324.

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Giger-Reverdin, Sylvie, Christine Duvaux-Ponter, Daniel Sauvant, Olivier Martin, Ivanor Nunes do Prado, and Rudy Müller. "Intrinsic buffering capacity of feedstuffs." Animal Feed Science and Technology 96, no. 1-2 (March 2002): 83–102. http://dx.doi.org/10.1016/s0377-8401(01)00330-3.

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Nestola, T., L. Orlandini, J. R. Beard, and Matteo Cesari. "COVID-19 and Intrinsic Capacity." Journal of nutrition, health & aging 24, no. 7 (May 28, 2020): 692–95. http://dx.doi.org/10.1007/s12603-020-1397-1.

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Lu, Wan-Hsuan. "Intrinsic capacity construct and influencing factors." Journal of nutrition, health and aging 28, no. 5 (May 2024): 100266. http://dx.doi.org/10.1016/j.jnha.2024.100266.

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Zheng, Wenwei, Dagong Fan, Min Feng, and Zhisong Wang. "The intrinsic load-resisting capacity of kinesin." Physical Biology 6, no. 3 (April 15, 2009): 036002. http://dx.doi.org/10.1088/1478-3975/6/3/036002.

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Werner, John, Arthur J. Ragauskas, and Jian E. Jiang. "Intrinsic Metal Binding Capacity of Kraft Lignins." Journal of Wood Chemistry and Technology 20, no. 2 (May 2000): 133–45. http://dx.doi.org/10.1080/02773810009349629.

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Chartouni, D. "Metal hydride fuel cell with intrinsic capacity." International Journal of Hydrogen Energy 27, no. 9 (September 2002): 945–52. http://dx.doi.org/10.1016/s0360-3199(01)00186-0.

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Nagae, Masaaki, Hiroyuki Umegaki, Hitoshi Komiya, Hirotaka Nakashima, Chisato Fujisawa, Kazuhisa Watanabe, Yosuke Yamada, and Shuzo Miyahara. "Intrinsic capacity in acutely hospitalized older adults." Experimental Gerontology 179 (August 2023): 112247. http://dx.doi.org/10.1016/j.exger.2023.112247.

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Zhou, Yaru, and Lina Ma. "Intrinsic Capacity in Older Adults: Recent Advances." Aging and disease 13, no. 2 (2022): 353. http://dx.doi.org/10.14336/ad.2021.0818.

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Pan, Yiming, Pan Liu, Yun Li, and Lina Ma. "ABNORMALITIES IN THE CITRATE CYCLE METABOLISM ARE ASSOCIATED WITH DECLINED INTRINSIC CAPACITY IN OLDER ADULTS." Innovation in Aging 6, Supplement_1 (November 1, 2022): 325–26. http://dx.doi.org/10.1093/geroni/igac059.1285.

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Abstract Background Aging is accompanied by a decline in physical and mental functions, manifested as the declines in intrinsic capacity. However, there is still a lack of understanding about the metabolic mechanisms underlying the declining intrinsic capacity. Objective: To explore the metabolic characteristics and pathways of the declines in intrinsic capacity with the assistance of metabolomics methods. Methods Our study recruited 38 participants in total. The Short Physical Performance Battery, Mini-Mental State Exam, 30-item Geriatric Depression Scale, self-reported hearing/visual impairment and Mini Nutritional Assessment were used to assess the five domains of intrinsic capacity respectively. The untargeted liquid chromatography-mass spectrometry-based metabolomics was performed on the serum of participants. Multivariate statistical analysis and pathway analysis were then implemented. Results Among the 38 participants aged 66.50±15.20 years, 22 were with the declines in at least one domain of intrinsic capacity. In the 349 identified metabolites, 35 were candidate biomarkers for declining intrinsic capacity with variable importance in the projection > 1.5 and p < 0.05. Citrate cycle, tryptophan metabolism, phenylalanine and tyrosine metabolism, and Arginine biosynthesis were significant pathways associated with the declines in intrinsic capacity. Conclusions Decreased intrinsic capacity is an age-related change with characteristic metabolomics features. Many pathways, especially the dysregulation of the citrate cycle metabolism, may be involved in the pathogenesis of intrinsic capacity decline.

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Yang, Ping, and Zhong Yang. "Enhancing intrinsic growth capacity promotes adult CNS regeneration." Journal of the Neurological Sciences 312, no. 1-2 (January 2012): 1–6. http://dx.doi.org/10.1016/j.jns.2011.08.037.

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Wentworth, A. D., L. H. Jones, P. Wentworth, K. D. Janda, and R. A. Lerner. "Antibodies have the intrinsic capacity to destroy antigens." Proceedings of the National Academy of Sciences 97, no. 20 (September 26, 2000): 10930–35. http://dx.doi.org/10.1073/pnas.97.20.10930.

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施, 建东. "Research Progress on Intrinsic Capacity of the Elderly." Advances in Clinical Medicine 13, no. 03 (2023): 3072–76. http://dx.doi.org/10.12677/acm.2023.133437.

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Mellado, Wilfredo, and Dianna E. Willis. "Ribosomal S6 kinases determine intrinsic axonal regeneration capacity." PLOS Biology 21, no. 4 (April 21, 2023): e3002094. http://dx.doi.org/10.1371/journal.pbio.3002094.

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Hsiao, Fei-Yuan, and Liang-Kung Chen. "Intrinsic capacity assessment works—let's move on actions." Lancet Healthy Longevity 5, no. 7 (July 2024): e448-e449. http://dx.doi.org/10.1016/s2666-7568(24)00110-7.

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Bautista, Emmanuel Gonzalez, Aarón Salinas Rodríguez, Ana Rivera Almaraz, and Betty Soledad Manrique Espinoza. "ARE INTRINSIC CAPACITY AND MULTIMORBIDITY ASSOCIATED TO FRIED’S FRAILTY REVERSIBILITY?" Innovation in Aging 6, Supplement_1 (November 1, 2022): 326. http://dx.doi.org/10.1093/geroni/igac059.1286.

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Abstract Our objective was to characterize older adults with reversible frailty in their baseline intrinsic capacity and multimorbidity status. MethodsWe used data from the most recent waves of the SAGE Mexico study (3 and 4), representative of older adults at a national level. Study n=749.We objectively measured gait speed and grip strength based on Fried's frailty criteria. Weight loss exhaustion was self-reported and physical activity (using the IPAQ).Reversible frailty was defined as going from frailty to pre-frail or robust and from pre-frail to robust. Worsening and stable frailty were coded similarly. Intrinsic capacity was measured using a summary index (0-100) based on five domains: cognition, locomotion, sensory, nutrition, and psychological. Multimorbidity was coded yes/no if the participant self-reported two or more chronic conditions. We compared the odds of being in the reverse group versus not in it according to baseline intrinsic capacity score and multimorbidity status, adjusting for age, sex, rural/urban, and wealth. ResultsReversible frailty=33% of those pre-frail or robust at baseline. Intrinsic capacity was higher in the reverse group than in those with worsening frailty but not significantly higher than those with stable frailty.Having multimorbidity significantly decreased the chances of frailty reversibility, adjusting for covariates. ConclusionsAs an expression of lifecourse damage to the physiological reserve, multimorbidity limits the chances of reversible frailty in Mexican older adults. High levels of intrinsic capacity did not characterize frailty reversibility in our study. Yet, low intrinsic capacity levels are a marker for older adults prone to frailty worsening.

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Chang, Mei-Ching, Yu-Tai Lo, Wei Lee, and Sheng-Yu Fan. "THE RELATIONSHIPS BETWEEN INTRINSIC CAPACITY AND FRAILTY AND DISABILITY IN OLDER OUTPATIENTS." Innovation in Aging 7, Supplement_1 (December 1, 2023): 1139–40. http://dx.doi.org/10.1093/geroni/igad104.3658.

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Abstract The ICOPE scale is developed by the WHO to assess intrinsic capacity, including cognition, mobility, nutrition, hearing, vision, and depression. However, the relationships between intrinsic capacity and frailty and disability were unknown. The purposes of this study were to explore the cut-off points of the ICOPE scale for frailty and disability in older outpatients, and the significant intrinsic capacities for frailty and disability. This study employed a cross-sectional research design. The participants were patients aged 65 and above attending the geriatric department of a medical center (n=397). The ICOPE scale, Clinical Frailty Scale (CFS), and Activity of Daily Living (ADL) scale were used. ROC curve analysis was used to determine the optimal cut-off points of the ICOPE scale for frailty and disability, and logistic regression for the significant intrinsic capacities related to frailty and disability. For frailty, the AUC value of abnormal intrinsic capacity was 0.79 (p < 0.001), with an optimal cut-off point of 2/3. For disability the AUC value of abnormal intrinsic capacity was 0.82 (p < 0.001), with an optimal cut-off point of 2/3. Logistic regression showed cognition, mobility, and nutrition related to frailty significantly; whereas cognition, mobility, nutrition, and hearing related to disability significantly. Older adults with three or more abnormal intrinsic capacities have a higher risk of frailty and disability. The problems of cognition, mobility, and nutrition were the risk factors of frailty and disability. Healthcare staff can pay attention to older outpatients with the problems of intrinsic capacities.

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Beard, John R., A. T. Jotheeswaran, Matteo Cesari, and Islene Araujo de Carvalho. "The structure and predictive value of intrinsic capacity in a longitudinal study of ageing." BMJ Open 9, no. 11 (November 2019): e026119. http://dx.doi.org/10.1136/bmjopen-2018-026119.

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ObjectivesTo assess the validity of the WHO concept of intrinsic capacity in a longitudinal study of ageing; to identify whether this overall measure disaggregated into biologically plausible and clinically useful subdomains; and to assess whether total capacity predicted subsequent care dependence.DesignStructural equation modelling of biomarkers and self-reported measures in the English Longitudinal Study of Ageing including exploratory factor analysis, exploratory bi-factor analysis and confirmatory factor analysis. Longitudinal mediation and moderation analysis of incident care dependence.SettingsCommunity, United Kingdom.Participants2560 eligible participants aged over 60 years.Main outcome measuresActivities of daily living (ADL) and instrumental activities of daily living (IADL).ResultsOne general factor (intrinsic capacity) and five subfactors emerged: locomotor, cognitive; psychological; sensory; and ‘vitality’. This structure is consistent with biological theory and the model had a good fit for the data (χ2=71.2 (df=39)). The summary score of intrinsic capacity and specific subfactors showed good construct validity. In a causal path model examining incident loss of ADL and IADL, intrinsic capacity had a direct relationship with the outcome—root mean square error of approximation (RMSEA)=0.02 (90% CI 0.001 to 0.05) and RMSEA=0.008 (90% CI0.001 to 0.03) respectively—and was a strong mediator for the effect of age, sex, wealth and education. Multimorbidity had an independent direct relationship with incident loss of ADLs but not IADLs, and also operated through intrinsic capacity. More of the indirect effect of personal characteristics on incident loss of ADLs and IADLs was mediated by intrinsic capacity than multimorbidity.ConclusionsThe WHO construct of intrinsic capacity appears to provide valuable predictive information on an individual’s subsequent functioning, even after accounting for the number of multimorbidities. The proposed general factor and subdomain structure may contribute to a transformative paradigm for future research and clinical practice.

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Gutiérrez-Robledo, Luis Miguel, Rosa Estela García-Chanes, and Mario Ulises Pérez-Zepeda. "Screening intrinsic capacity and its epidemiological characterization: a secondary analysis of the Mexican Health and Aging Study." Revista Panamericana de Salud Pública 45 (September 13, 2021): 1. http://dx.doi.org/10.26633/rpsp.2021.121.

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Objective. To describe the levels of intrinsic capacity and those factors related to its decline in Mexican older adults, using the Mexican Health and Aging Study. Methods. This is a cross-sectional secondary analysis of the 2015 data of the Mexican Health and Aging Study, including adults aged 50 years and above. Selected questions were included to represent each domain of intrinsic capacity screening: cognition, depression, hearing, vision, anorexia, weight loss, and mobility. Sociodemographic characteristics, psychosocial factors, and health conditions were included to assess their association with intrinsic capacity. Further categories were established to assess not only individual characteristics but also different groupings. Along with descriptive statistics, multinomial regression models were performed. Results. From a total of 12 459 adults aged 50 years and above, 54.7% were women and the average age was 71.2 years; 87.8% of the individuals had at least one intrinsic capacity domain affected, and mobility had the highest frequency (47.6%). All domains showed a trend of increasing with age and were higher among women. Self-rated health, chronic diseases, number of visits to a physician in the last year, and ≥2 affected activities of daily living were consistently associated with more intrinsic capacity domains affected. Conclusions. Decreased levels of intrinsic capacity in Mexican older people are associated with less schooling, self-rated health, chronic diseases, visits to a physician, and activities of daily living.

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Cesari, M. "INTERSECTIONS BETWEEN FRAILTY AND THE CONCEPT OF INTRINSIC CAPACITY." Innovation in Aging 1, suppl_1 (June 30, 2017): 692. http://dx.doi.org/10.1093/geroni/igx004.2479.

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Demmig-Adams, Barbara, Jared J. Stewart, and William W. Adams. "Environmental regulation of intrinsic photosynthetic capacity: an integrated view." Current Opinion in Plant Biology 37 (June 2017): 34–41. http://dx.doi.org/10.1016/j.pbi.2017.03.008.

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Goulet, Grant C., Neil R. Halonen, Jaqueline H. Cole, Lauren G. Koch, Steve L. Britton, Michael D. Morris, Ronald F. Zernicke, and Ken M. Kozloff. "Influence of Intrinsic Aerobic Exercise Capacity on Skeletal Health." Medicine & Science in Sports & Exercise 42 (May 2010): 821. http://dx.doi.org/10.1249/01.mss.0000386535.36330.dd.

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Choi, Joungil, Krish Chandrasekaran, Tyler G. Demarest, Tibor Kristian, Su Xu, Kadambari Vijaykumar, Kevin Geoffrey Dsouza, et al. "Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity." Annals of Clinical and Translational Neurology 1, no. 8 (August 2014): 589–604. http://dx.doi.org/10.1002/acn3.86.

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Gutierrez-Robledo, Luis Miguel, and R. E. García-Chanes. "Intrinsic Capacity Trajectories: The Underlying Social and Economic Determinants." Journal of nutrition, health & aging 27, no. 3 (March 10, 2023): 172–73. http://dx.doi.org/10.1007/s12603-023-1896-1.

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Zhou, Jia, Hui Chang, Minmin Leng, and Zhiwen Wang. "Intrinsic Capacity to Predict Future Adverse Health Outcomes in Older Adults: A Scoping Review." Healthcare 11, no. 4 (February 4, 2023): 450. http://dx.doi.org/10.3390/healthcare11040450.

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Objective: Intrinsic capacity is recognized as an important determinant of healthy aging and well-being of older adults; however, relatively little is known about the intrinsic capacity of older adults to predict adverse health outcomes. The study aimed to examine which adverse health outcomes of older adults can be predicted by intrinsic capacity. Methods: The study was conducted using the scoping review methodological framework of Arksey and O’Malley. A systematic literature search of nine electronic databases (i.e., Pubmed, Embase, Cochrane library, Web of science, CINAHL, China National Knowledge Infrastructure, VIP, Wanfang, and the Chinese Biological Medical Literature Database) were performed from the database’s inception to 1 March 2022. Results: Fifteen longitudinal studies were included. A series of adverse health outcomes were assessed, including physical function (n = 12), frailty (n = 3), falls (n = 3), mortality (n = 6), quality of life (n = 2) and other adverse health outcomes (n = 4). Conclusions: Intrinsic capacity could predict some adverse health outcomes of different follow-up times for older adults; however, due to the small number of studies and sample size, more high-quality studies are necessary to explore the longitudinal relationships between intrinsic capacity and adverse health outcomes in the future.

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Bahizi, Lia. "Intrinsic dignity." Speki. Nordic Philosophy and Education Review 1, no. 1 (February 9, 2024): 1–17. http://dx.doi.org/10.5617/speki.10311.

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Dignity has often been used to signify a ground for a particularly serious kind of moral consideration, the scope of which has been debated. Therefore, I argue that an inclusive conception of dignity is central in determining the normative aims of education, and the moral responsibilities that adult teachers should have in learning relationships with children. The aim of the paper is to argue for a view of dignity as a regulative ideal beyond the dichotomy of moral agents and patients that can be (imperfectly) realized through moral perfectionism. In this article I show how commonly held neo-Aristotelean and neo-Kantian interpretations that view dignity as an intrinsic value grounded in certain capacities, mainly the capacity for reason, can have limiting implications for the view of children as moral subjects. By presenting alternative interpretations of Aristotle and Kant, I will seek to challenge these limited views on dignity and expand the conception of dignity to not only being grounded in certain capacities of moral agents and patients, but in morality itself. The argument leads to problematizing moral perfectionism in education that is not counter-balanced by moments of transcending our own intentions to be good.

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Ma, Carol, Angela Y. M. Leung, Denise Chua, Wai Choo Teo, Laura Bee Gek Tay, and Wai Chong Ng. "INTRINSIC CAPACITY OF OLDER ADULTS IN SINGAPORE USING WHO INTEGRATED CARE FOR OLDER PEOPLE (ICOPE) FRAMEWORK." Innovation in Aging 7, Supplement_1 (December 1, 2023): 893–94. http://dx.doi.org/10.1093/geroni/igad104.2875.

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Abstract The World Health Organization (WHO) proposed the Integrated Care for Older People (ICOPE) approach to guide health systems in better supporting the intrinsic capacity and functional ability of older adults to enable healthy aging (Briggs et al., 2018; de Carvalho et al., 2019). This approach is aligned with Singapore’s Healthier SG initiative, which aims to build a good healthcare system that promotes better health and quality of life for everyone. Recent studies have shown that older adults experience intrinsic capacity decline in various countries, including Singapore, highlighting the importance of targeted interventions to maintain functionality and quality of life in old age (Beard et al., 2019; Liu et al., 2021; Tay et al., 2022). In this cross-sectional study, 367 participants were assessed by 43 ICOPE assessors, of whom 77.4% (n=284) had impairments in intrinsic capacity. The three most prevalent intrinsic capacity impairments were visual impairment (42%), hearing loss (33.5%), and cognitive decline (31.3%), followed by limited mobility (24.3%), malnutrition (16.1%), and depressive symptoms (16.1%). Furthermore, 22.6% of participants were unaware of any elderly care services available in the community, and 8.2% did not know where to seek help in case of problems. These findings emphasize the need for ICOPE assessments at the community level to promote early detection of intrinsic capacity impairments and interventions. More discussion of the care pathway, together with health professionals, older adults, and caregivers, should be the next step to offer diagnostic assessment and guide self-management of intrinsic capacity impairment for among older adults.

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Lim, Kian-Yuan, Hui-Chen Lo, In-Fai Cheong, Yi-Yen Wang, Zi-Rong Jian, I.-Chen Chen, Yun-Chun Chan, Shyh-Dye Lee, Chi-Chun Chou, and Feili Lo Yang. "Healthy Eating Enhances Intrinsic Capacity, Thus Promoting Functional Ability of Retirement Home Residents in Northern Taiwan." Nutrients 14, no. 11 (May 26, 2022): 2225. http://dx.doi.org/10.3390/nu14112225.

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Healthy aging is defined as the process of developing and maintaining functional ability in older age with intrinsic capacity, the composite of all the physical and mental capacities of an individual, being the core. This study was conducted to explore the intervention effects of improved dietary quality on intrinsic capacity. A prospective single-group interventional quasi-experimental study with 59 functional independent older adults from retirement homes were recruited. Texture-modified plant-based dietary supplements were provided. In addition, dietary intake, functional ability, and intrinsic capacity in vitality, locomotion, cognition, and psychological capacity were assessed. Vitality was captured by nutritional status, muscle strength, and cardiorespiratory endurance. Locomotor capacity was assessed based on the performance of physical fitness in backscratch test, chair-sit-and-reach test, chair-stand test, one-foot-standing test, and gaits peed. Psychomotor capacity and cognition were measured by using 15-item Geriatric Depression Scale (GDS-15) and Mini-Mental State Examination (MMSE), respectively. In a 4-month of intervention, after controlling for baseline values and covariates, participants with higher dietary intervention adherence showed a significant improvement over time in vitality captured by cardiorespiratory endurance (Pinteraction = 0.009) and significant improvement in locomotion captured by gait speed (Pclusters = 0.034). A significant decrease in the chair-stand test (Ptime = <0.001) and MMSE (Ptime = 0.022) was observed during the four months of intervention. Enhanced intrinsic capacity further contributed to the improvement of ADL over time (Pinteraction = 0.034). In conclusion, healthy eating enhances intrinsic capacity in vitality and locomotion thus promoting functional ability among older adults.

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Courtney, Sean M., and Michael P. Massett. "Effect of chromosome substitution on intrinsic exercise capacity in mice." F1000Research 3 (January 13, 2014): 9. http://dx.doi.org/10.12688/f1000research.3-9.v1.

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Previous research identified a locus on Chromosome 14 as an important regulator of endurance exercise capacity in mice. The aim of this study was to investigate the effect of chromosome substitution on intrinsic exercise capacity and identify quantitative trait loci (QTL) associated with exercise capacity in mice. Mice from a chromosome substitution strain (CSS) derived from A/J and C57Bl/6J (B6), denoted as B6.A14, were used to assess the contribution of Chromosome 14 to intrinsic exercise capacity. All mice performed a graded exercise test to exhaustion to determine exercise capacity expressed as time (min) or work (kg·m). Exercise time and work were significantly greater in B6 mice than B6.A14 and A/J mice, indicating the presence of a QTL on Chromosome 14 for exercise capacity. To localize exercise-related QTL, 155 B6.A14 x B6 F2 mice were generated for linkage analysis. Suggestive QTL for exercise time (57 cM, 1.75 LOD) and work (57 cM, 2.08 LOD) were identified in the entire B6.A14 x B6 F2 cohort. To identify putative sex-specific QTL, male and female F2 cohorts were analyzed separately. In males, a significant QTL for exercise time (55 cM, 2.28 LOD) and a suggestive QTL for work (55 cM, 2.19 LOD) were identified. In the female cohort, no QTL was identified for time, but a suggestive QTL for work was located at 16 cM (1.8 LOD). These data suggest that one or more QTL on Chromosome 14 regulate exercise capacity. The putative sex-specific QTL further suggest that the genetic architecture underlying exercise capacity is different in males and females. Overall, the results of this study support the use of CSS as a model for the genetic analysis of exercise capacity. Future studies should incorporate the full panel of CSS using male and female mice to dissect the genetic basis for differences in exercise capacity.

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Courtney, Sean M., and Michael P. Massett. "Effect of chromosome substitution on intrinsic exercise capacity in mice." F1000Research 3 (May 28, 2014): 9. http://dx.doi.org/10.12688/f1000research.3-9.v2.

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Previous research identified a locus on Chromosome 14 as an important regulator of endurance exercise capacity in mice. The aim of this study was to investigate the effect of chromosome substitution on intrinsic exercise capacity and identify quantitative trait loci (QTL) associated with exercise capacity in mice. Mice from a chromosome substitution strain (CSS) derived from A/J and C57Bl/6J (B6), denoted as B6.A14, were used to assess the contribution of Chromosome 14 to intrinsic exercise capacity. All mice performed a graded exercise test to exhaustion to determine exercise capacity expressed as time (min) or work (kg·m). Exercise time and work were significantly greater in B6 mice than B6.A14 and A/J mice, indicating the presence of a QTL on Chromosome 14 for exercise capacity. To localize exercise-related QTL, 155 B6.A14 x B6 F2 mice were generated for linkage analysis. Suggestive QTL for exercise time (57 cM, 1.75 LOD) and work (57 cM, 2.08 LOD) were identified in the entire B6.A14 x B6 F2 cohort. To identify putative sex-specific QTL, male and female F2 cohorts were analyzed separately. In males, a significant QTL for exercise time (55 cM, 2.28 LOD) and a suggestive QTL for work (55 cM, 2.19 LOD) were identified. In the female cohort, no QTL was identified for time, but a suggestive QTL for work was located at 16 cM (1.8 LOD). These data suggest that one or more QTL on Chromosome 14 regulate exercise capacity. The putative sex-specific QTL further suggest that the genetic architecture underlying exercise capacity is different in males and females. Overall, the results of this study support the use of CSS as a model for the genetic analysis of exercise capacity. Future studies should incorporate the full panel of CSS using male and female mice to dissect the genetic basis for differences in exercise capacity.

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Tian, Amy Wei, and Christine Soo. "Enriching individual absorptive capacity." Personnel Review 47, no. 5 (August 6, 2018): 1116–32. http://dx.doi.org/10.1108/pr-04-2017-0110.

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Purpose The purpose of this paper is to offer an understanding of the development and consequence of absorptive capacity (AC) at the individual level of analysis. The authors assess how perception of organizational commitment to learning and intrinsic motivation affects individual potential AC, and employee creativity and job performance as the key outcomes of individual AC. Furthermore, the authors examined the dual role of realized AC as a mediator in the potential AC-creativity relationship, and a moderator on the creativity-job performance relationship. Design/methodology/approach This paper draws from 125 paired supervisor-employee survey data, where supervisors rated subordinates’ creativity and job performance. Hierarchical regression was used to test the proposed hypotheses. Findings The results confirm that both perception of organizational commitment to learning and intrinsic motivation contribute to the development of individual potential AC (above and beyond extrinsic motivation). Individual realized AC mediated the potential AC-creativity relationship. Employee creativity was positively related to job performance. Research limitations/implications This study speaks directly to the question of how an organization can encourage its employees to absorb new knowledge, and the benefits of employee learning activities on their creativity and job performance. Originality/value This is one of the first studies to offer a more nuanced understanding of the development and consequences of individual AC – a level of analysis has been lack of empirical studies. It further point out how individual characteristic and perceptions can influence their learning capacity, and in turn, their performance.

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Sollanek, Kurt J., Ashley J. Smuder, Michael P. Wiggs, Aaron B. Morton, Lauren G. Koch, Steven L. Britton, and Scott K. Powers. "Role of intrinsic aerobic capacity and ventilator-induced diaphragm dysfunction." Journal of Applied Physiology 118, no. 7 (April 1, 2015): 849–57. http://dx.doi.org/10.1152/japplphysiol.00797.2014.

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Prolonged mechanical ventilation (MV) leads to rapid diaphragmatic atrophy and contractile dysfunction, which is collectively termed “ventilator-induced diaphragm dysfunction” (VIDD). Interestingly, endurance exercise training prior to MV has been shown to protect against VIDD. Further, recent evidence reveals that sedentary animals selectively bred to possess a high aerobic capacity possess a similar skeletal muscle phenotype to muscles from endurance trained animals. Therefore, we tested the hypothesis that animals with a high intrinsic aerobic capacity would naturally be afforded protection against VIDD. To this end, animals were selectively bred over 33 generations to create two divergent strains, differing in aerobic capacity: high-capacity runners (HCR) and low-capacity runners (LCR). Both groups of animals were subjected to 12 h of MV and compared with nonventilated control animals within the same strains. As expected, contrasted to LCR animals, the diaphragm muscle from the HCR animals contained higher levels of oxidative enzymes (e.g., citrate synthase) and antioxidant enzymes (e.g., superoxide dismutase and catalase). Nonetheless, compared with nonventilated controls, prolonged MV resulted in significant diaphragmatic atrophy and impaired diaphragm contractile function in both the HCR and LCR animals, and the magnitude of VIDD did not differ between strains. In conclusion, these data demonstrate that possession of a high intrinsic aerobic capacity alone does not afford protection against VIDD. Importantly, these results suggest that endurance exercise training differentially alters the diaphragm phenotype to resist VIDD. Interestingly, levels of heat shock protein 72 did not differ between strains, thus potentially representing an important area of difference between animals with intrinsically high aerobic capacity and exercise-trained animals.

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Kalapsazova, Mariya, Ekaterina Zhecheva, and Radostina Stoyanova. "(Invited) Colossal Intercalation Capacity: Sci-Fi Idea or Intrinsic Property?" ECS Meeting Abstracts MA2021-02, no. 2 (October 19, 2021): 202. http://dx.doi.org/10.1149/ma2021-022202mtgabs.

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Koch, Lauren Gerard, Ole J. Kemi, Nathan Qi, Sean X. Leng, Piter Bijma, Lori J. Gilligan, John E. Wilkinson, et al. "Intrinsic Aerobic Capacity Sets a Divide for Aging and Longevity." Circulation Research 109, no. 10 (October 28, 2011): 1162–72. http://dx.doi.org/10.1161/circresaha.111.253807.

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BJÖRNDAHL, LARS, and ULRIK KVIST. "Loss of an intrinsic capacity for human sperm chromatin decondensation." Acta Physiologica Scandinavica 124, no. 2 (June 1985): 189–94. http://dx.doi.org/10.1111/j.1748-1716.1985.tb07651.x.

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Cesari, Matteo, Islene Araujo de Carvalho, Jotheeswaran Amuthavalli Thiyagarajan, Cyrus Cooper, Finbarr C. Martin, Jean-Yves Reginster, Bruno Vellas, and John R. Beard. "Evidence for the Domains Supporting the Construct of Intrinsic Capacity." Journals of Gerontology: Series A 73, no. 12 (February 2, 2018): 1653–60. http://dx.doi.org/10.1093/gerona/gly011.

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Stevenson, Christopher S., and Liang Yew-Booth. "Is intrinsic aerobic exercise capacity a determinant of COPD susceptibility?" Pulmonary Pharmacology & Therapeutics 26, no. 4 (August 2013): 459–63. http://dx.doi.org/10.1016/j.pupt.2013.01.004.

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Wang, Jinjiao, Leanne Boehm, and Lorraine C. Mion. "Intrinsic capacity in older hospitalized adults: Implications for nursing practice." Geriatric Nursing 38, no. 4 (July 2017): 359–61. http://dx.doi.org/10.1016/j.gerinurse.2017.06.008.

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Khorshidi, Morteza, and Ning Lu. "Intrinsic Relation between Soil Water Retention and Cation Exchange Capacity." Journal of Geotechnical and Geoenvironmental Engineering 143, no. 4 (April 2017): 04016119. http://dx.doi.org/10.1061/(asce)gt.1943-5606.0001633.

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Kunzevitzky, Noelia J., Kevin T. Willeford, William J. Feuer, Monica V. Almeida, and Jeffrey L. Goldberg. "Amacrine Cell Subtypes Differ in Their Intrinsic Neurite Growth Capacity." Investigative Opthalmology & Visual Science 54, no. 12 (November 15, 2013): 7603. http://dx.doi.org/10.1167/iovs.13-12691.

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KOCH, LAUREN GERARD, and STEVEN L. BRITTON. "Artificial selection for intrinsic aerobic endurance running capacity in rats." Physiological Genomics 5, no. 1 (February 7, 2001): 45–52. http://dx.doi.org/10.1152/physiolgenomics.2001.5.1.45.

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Artificial selection for intrinsic aerobic endurance running capacity was started using genetically heterogeneous N:NIH stock of rats as a founder population ( n = 168). Selection for low and high capacity was based upon distance run to exhaustion on a motorized treadmill using a velocity-ramped running protocol. The starting velocity was 10 m/min and was increased by 1 m/min every 2 min (slope was constant at 15°). At each generation, within-family selection was practiced using 13 families for both the low and high lines. A rotational breeding paradigm maintained the coefficient of inbreeding at less than 1% per generation. On average the founder population ran to exhaustion in 355 ± 11 m. Six generations of selection produced lines that differed in running capacity by 171%, with most of the change occurring in the high line. At generation 6 the low line ran 310 ± 8 m and the high line 839 ± 21 m at exhaustion. Selection for running capacity produced changes in body weight as a correlated trait. By generation 6, the low-line females were 20% heavier than the high-line females, and the low-line males were 16% heavier than the high-line males.

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Si, Yafei, Katja Hanewald, Shu Chen, Bingqin Li, Hazel Bateman, and John Beard. "Life-course inequalities in intrinsic capacity and healthy ageing, China." Bulletin of the World Health Organization 101, no. 05 (May 1, 2023): 307–16. http://dx.doi.org/10.2471/blt.22.288888.

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Chen, Jie, Ying Xie, Yiting Sun, Ruichen Zang, Yuhao Sun, Lintao Dan, Xuanding Wang, and Therese Hesketh. "Life-course inequalities in intrinsic capacity and healthy ageing, China." Bulletin of the World Health Organization 101, no. 05 (May 1, 2023): 317–25. http://dx.doi.org/10.2471/blt.22.289435.

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Hamaker, Marije, Sanne Gijzel, Siri Rostoft, and Frederiek van den Bos. "Intrinsic capacity and resilience: Taking frailty to the next level." Journal of Geriatric Oncology 14, no. 2 (March 2023): 101421. http://dx.doi.org/10.1016/j.jgo.2022.101421.

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Chen, Yi-Jung, Shikha Kukreti, Hsin-Lun Yang, Chien-Chih Liu, Ya-Chin Yeh, Xavier C. C. Fung, Chieh-Hsiu Liu, et al. "Psychometric Properties of Instruments Assessing Intrinsic Capacity: A Systematic Review." Asian Journal of Social Health and Behavior 6, no. 4 (2023): 141–55. http://dx.doi.org/10.4103/shb.shb_343_23.

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Introduction: Intrinsic capacity (IC) is a multidimensional indicator proposed by the World Health Organization that encompasses mental and physical capacities associated with functional ability. With the help of IC, different pathways of aging can be better understood, and heterogeneity can be captured more effectively. Before IC can be clinically incorporated, it requires valid and usable instruments alongside a comprehensive evaluation of psychometric evidence. Therefore, the present systematic review critically appraised, compared, and summarized the measurement properties of existing IC instruments used by older people. Methods: Published studies were searched in seven databases: EMBASE, MEDLINE, PsycINFO, PubMed, ScienceDirect, Scopus, and Web of Science, until August 2022. The measurement properties of the IC measures were evaluated using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN). Results: Of the 582 papers initially identified, 10 studies were eligible for inclusion. Seven instruments were classified as five-domain measures, and three as more than five-domain measures. No instrument assessed all nine criteria in the psychometric properties evaluation outlined by COSMIN. The most reported psychometric properties were construct validity (n = 8), measurement invariance (n = 8), and structural validity (n = 7). There was underreporting of content validity, reliability, and measurement error. Conclusion: The present review indicated a general lack of psychometric assessments of existing IC instruments with independent studies as their evidence base. There is a need to explore further the associations of IC and its five domains of interaction, which express the ability of individuals to interact with the environment and affect their functional ability.

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Rivas, Donato A., Sarah J. Lessard, Misato Saito, Anna M. Friedhuber, Lauren G. Koch, Steven L. Britton, Ben B. Yaspelkis, and John A. Hawley. "Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300, no. 4 (April 2011): R835—R843. http://dx.doi.org/10.1152/ajpregu.00659.2010.

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Chronic metabolic diseases develop from the complex interaction of environmental and genetic factors, although the extent to which each contributes to these disorders is unknown. Here, we test the hypothesis that artificial selection for low intrinsic aerobic running capacity is associated with reduced skeletal muscle metabolism and impaired metabolic health. Rat models for low- (LCR) and high- (HCR) intrinsic running capacity were derived from genetically heterogeneous N:NIH stock for 20 generations. Artificial selection produced a 530% difference in running capacity between LCR/HCR, which was associated with significant functional differences in glucose and lipid handling by skeletal muscle, as assessed by hindlimb perfusion. LCR had reduced rates of skeletal muscle glucose uptake (∼30%; P = 0.04), glucose oxidation (∼50%; P = 0.04), and lipid oxidation (∼40%; P = 0.02). Artificial selection for low aerobic capacity was also linked with reduced molecular signaling, decreased muscle glycogen, and triglyceride storage, and a lower mitochondrial content in skeletal muscle, with the most profound changes to these parameters evident in white rather than red muscle. We show that a low intrinsic aerobic running capacity confers reduced insulin sensitivity in skeletal muscle and is associated with impaired markers of metabolic health compared with high intrinsic running capacity. Furthermore, selection for high running capacity, in the absence of exercise training, endows increased skeletal muscle insulin sensitivity and oxidative capacity in specifically white muscle rather than red muscle. These data provide evidence that differences in white muscle may have a role in the divergent aerobic capacity observed in this generation of LCR/HCR.

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Foehring, R. C., X. F. Zhang, J. C. F. Lee, and J. C. Callaway. "Endogenous Calcium Buffering Capacity of Substantia Nigral Dopamine Neurons." Journal of Neurophysiology 102, no. 4 (October 2009): 2326–33. http://dx.doi.org/10.1152/jn.00038.2009.

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Dopamine (DA)-containing cells from the substantia nigra pars compacta (SNc) play a major role in the initiation of movement. Loss of these cells results in Parkinson's disease (PD). Changes in intracellular calcium ion concentration ([Ca2+]i) elicit several events in DA cells, including spike afterhyperpolarizations (AHPs) and subthreshold oscillations underlying autonomous firing. Continuous Ca2+ load due to Ca2+-dependent rhythmicity has been proposed to cause the death of DA cells in PD and normal aging. Because of the physiological and pathophysiological importance of [Ca2+]i in DA cells, we characterized their intrinsic Ca2+-buffering capacity (KS) in brain slices. We introduced a fluorescent Ca2+-sensitive exogenous buffer (200 μM fura-2) and cells were tracked from break-in until steady state by stimulating with a single action potential (AP) every 30 s and measuring the Ca2+ transient from the proximal dendrite. DA neurons filled exponentially with a τ of about 5–6 min. [Ca2+]i was assumed to equilibrate between the endogenous Ca2+ buffer and the exogenous Ca2+ indicator buffer. Intrinsic buffering was estimated by extrapolating from the linear relationships between the amplitude or time constant of the Ca2+ transients versus [fura-2]. Extrapolated Ca2+-transients in the absence of fura-2 had mean peak amplitudes of 293.7 ± 65.3 nM and τ = 124 ± 13 ms (postnatal day 13 [P13] to P17 animals). Intrinsic buffering increased with age in DA neurons. For cells from animals P13–P17, KS was estimated to be about 110 ( n = 20). In older animals (P25–P32), the estimate was about 179 ( n = 10). These relatively low values may reflect the need for rapid Ca2+ signaling, e.g., to allow activation of sK channels, which shape autonomous oscillations and burst firing. Low intrinsic buffering may also make DA cells vulnerable to Ca2+-dependent pathology.

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Prímola-Gomes, Thales N., Lúcia A. Campos, Sandra Lauton-Santos, Cláudio H. Balthazar, Silvia Guatimosim, Luciano S. A. Capettini, Virgínia S. Lemos, et al. "Exercise capacity is related to calcium transients in ventricular cardiomyocytes." Journal of Applied Physiology 107, no. 2 (August 2009): 593–98. http://dx.doi.org/10.1152/japplphysiol.91218.2008.

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The aim of the present study was to evaluate the Ca2+ handling and contractility properties of cardiomyocytes isolated from rats with high intrinsic aerobic exercise capacity. Standard-performance (SP) and high-performance (HP) rats were categorized with a treadmill progressive exercise test according to the exercise time to fatigue (TTF). The SP group included rats with TTF between 16.63 and 46.57 min, and the HP group included rats with TTF >46.57 min. Isolated ventricular cardiomyocytes were dissociated from the hearts of SP and HP rats, and intracellular global Ca2+ ([Ca2+]i) transients were measured. The [Ca2+]i transient peak was increased in the HP group relative to the SP group (5.54 ± 0.31 vs. 4.18 ± 0.12 F/F0; P ≤ 0.05) and was positively correlated with the TTF attained during the progressive test ( r = 0.81). We also performed contractility measurements in isolated cardiomyocytes and found higher amplitude of contraction in the HP group compared with the SP group (6.7 ± 0.2 vs. 6.0 ± 0.3% resting cell length; P ≤ 0.05). To reinforce the intrinsic differences between SP and HP rats, we performed Western blot experiments and observed increased expression of sarco(endo)plasmic reticulum Ca2+-ATPase type 2a (1.30 ± 0.07 vs. 1.74 ± 0.18 arbitrary units; P ≤ 0.05) and ryanodine receptor type 2 (1.86 ± 0.13 vs. 3.57 ± 0.12 arbitrary units; P ≤ 0.05) in HP rats. In summary, our data showed important intrinsic differences in cardiomyocyte properties that could explain some of the divergence observed in rats with high intrinsic aerobic exercise capacity.

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Tata, Samir, Zakaria Maamar, Djamel Belaïd, and Khouloud Boukadi. "Capacity-Driven Web Services." International Journal of Systems and Service-Oriented Engineering 1, no. 4 (October 2010): 65–88. http://dx.doi.org/10.4018/jssoe.2010100105.

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This paper presents the concepts, definitions, issues, and solutions that revolve around the adoption of capacity-driven Web services. Because of the intrinsic characteristics of these Web services compared to regular, mono-capacity Web services, they are examined in a different way and across four steps denoted by description, discovery, composition, and enactment. Implemented as operations to execute at run-time, the capacities that empower a Web service are selected with respect to requirements put on this Web service such as data quality and network bandwidth. In addition, this paper reports on first the experiments that were conducted to demonstrate the feasibility of capacity-driven Web services, and also the research opportunities that will be pursued in the future.

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Aguado, Lauren C., Tristan X. Jordan, Emily Hsieh, Daniel Blanco-Melo, John Heard, Maryline Panis, Marco Vignuzzi, and Benjamin R. tenOever. "Homologous recombination is an intrinsic defense against antiviral RNA interference." Proceedings of the National Academy of Sciences 115, no. 39 (September 12, 2018): E9211—E9219. http://dx.doi.org/10.1073/pnas.1810229115.

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RNA interference (RNAi) is the major antiviral defense mechanism of plants and invertebrates, rendering the capacity to evade it a defining factor in shaping the viral landscape. Here we sought to determine whether different virus replication strategies provided any inherent capacity to evade RNAi in the absence of an antagonist. Through the exploitation of host microRNAs, we recreated an RNAi-like environment in vertebrates and directly compared the capacity of positive- and negative-stranded RNA viruses to cope with this selective pressure. Applying this defense against four distinct viral families revealed that the capacity to undergo homologous recombination was the defining attribute that enabled evasion of this defense. Independent of gene expression strategy, positive-stranded RNA viruses that could undergo strand switching rapidly excised genomic material, while negative-stranded viruses were effectively targeted and cleared upon RNAi-based selection. These data suggest a dynamic relationship between host antiviral defenses and the biology of virus replication in shaping pathogen prevalence.

Journal articles on the topic 'Intrinsic capacity'

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