Relevant bibliographies by topics / Intravenous antibiotics

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Intravenous antibiotics'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "Intravenous antibiotics"

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Niimi, Rui, Masahiro Hasegawa, Goshin Kawamura, and Akihiro Sudo. "One-Day Antibiotic Infusion for the Prevention of Postoperative Infection Following Arthroplasty: A Case Control Study." ISRN Orthopedics 2011 (July 5, 2011): 1–4. http://dx.doi.org/10.5402/2011/839641.

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Intravenous antibiotics effectively reduce the prevalence of postoperative infection. However, Japanese orthopaedic surgeons have no consensus with regard to the optimal duration of prophylaxis. The aim of this study is to compare the outcome of one-day intravenous antibiotic administration with that of long-term intravenous antibiotic administration. Patients who underwent total hip or knee arthroplasty were divided into 2 groups to receive one of 2 prophylactic protocols retrospectively. Group A (223 patients) received intravenous antibiotics twice only on the day of surgery, whereas Group B (104 patients) received intravenous antibiotics for at least 3 days after surgery. We analyzed the wound infection rate and monitored liver and renal functions. None of these patients had a postoperative infection. No liver dysfunction and renal dysfunction were observed. One-day antibiotic infusion was as effective as long-term antibiotics in preventing infection after arthroplasty and achieved greater cost effectiveness.
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Connor, Kathryn A. "New Intravenous Antibiotics." AACN Advanced Critical Care 21, no. 3 (2010): 237–40. http://dx.doi.org/10.1097/nci.0b013e3181e06091.

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&NA;. "New Intravenous Antibiotics." AACN Advanced Critical Care 21, no. 3 (2010): 241–42. http://dx.doi.org/10.1097/nci.0b013e3181efbfdc.

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Nguyen, Phuong TK, Hoang T. Tran, Dominic A. Fitzgerald, Steve M. Graham, and Ben J. Marais. "Antibiotic use in children hospitalised with pneumonia in Central Vietnam." Archives of Disease in Childhood 105, no. 8 (February 20, 2020): 713–19. http://dx.doi.org/10.1136/archdischild-2019-317733.

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Background and objectivesExcessive use of antibiotics has been noted in children with respiratory tract infections in Vietnam, but antibiotic use in hospitalised children is poorly documented. Antibiotic use and direct healthcare costs in children hospitalised with pneumonia in central Vietnam were assessed.MethodsA prospective descriptive study of children under 5 years old admitted with a primary admission diagnosis of ‘pneumonia’ to the Da Nang Hospital for Women and Children over 1 year.ResultsOf 2911 children hospitalised with pneumonia, 2735 (94.0%) were classified as ‘non-severe’ pneumonia by the admitting physician. In total, 2853 (98.0%) children received antibiotics. Intravenous antibiotics were given to 336 (12.3%) children with ‘non-severe’ and 157/176 (89.2%) children with ‘severe’ pneumonia; those with ‘non-severe’ pneumonia accounted for 68.2% (336/493) of intravenous antibiotics given. Only 19.3% (95/493) of children on intravenous antibiotics were stepped down to an oral antibiotic. Cefuroxime was the preferred oral agent, and ceftriaxone was the preferred injectable agent. Hospital admission for oral antibiotics in ‘non-severe’ pneumonia was a major cost driver, with an average direct cost of US$78.9 per patient, accounting for 54.0% of the total hospitalisation cost in the study cohort. In addition, 336 (12.3%) children with non-severe pneumonia received intravenous antibiotics without indication, accounting for a further 23.2% of hospitalisation costs.ConclusionLimiting unnecessary hospitalisation and considering early intravenous to oral step down antibiotic will reduce direct health system costs and morbidity in children with respiratory tract infections in Vietnam.
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Coulthard, M. G., and W. H. Lamb. "ANTIBIOTICS: INTRAMUSCULAR OR INTRAVENOUS?" Lancet 326, no. 8462 (November 1985): 1015. http://dx.doi.org/10.1016/s0140-6736(85)90567-7.

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Chuong, Robert. "Intravenous antibiotics: Avoiding complications." Journal of Oral and Maxillofacial Surgery 43, no. 5 (May 1985): 395. http://dx.doi.org/10.1016/0278-2391(85)90272-1.

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Konarzewski, W. H., I. H. Wilson, and P. Burke. "Intravenous antibiotics and gangrene." Anaesthesia 40, no. 11 (November 1985): 1141. http://dx.doi.org/10.1111/j.1365-2044.1985.tb10637.x.

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Tsang, P. "Oral versus intravenous antibiotics." BMJ 311, no. 7006 (September 9, 1995): 685. http://dx.doi.org/10.1136/bmj.311.7006.685a.

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DAVIS, JANET L. "Intravenous Antibiotics for Endophthalmitis." American Journal of Ophthalmology 122, no. 5 (November 1996): 724–26. http://dx.doi.org/10.1016/s0002-9394(14)70493-3.

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HARRIS, LeROY F., THOMAS F. BUCKLE, and FRED L. COFFEY. "Intravenous Antibiotics at Home." Southern Medical Journal 79, no. 2 (February 1986): 193–96. http://dx.doi.org/10.1097/00007611-198602000-00014.

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Dissertations / Theses on the topic "Intravenous antibiotics"

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Van, Niekerk Anida. "Implementation of intravenous to oral antibiotic switch therapy guidelines in the general medical wards of a tertiary level hospital." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1325.

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The overuse of antibiotics and consequent resistance is a common problem in medical practice worldwide. Switch therapy is a technique that can be applied to streamline antibiotic therapy reducing unnecessary prolonged Intravenous (IV) antibiotic therapy. Antibiotic switch therapy has several other benefits such as: decreasing length of hospital stay; decreasing the incidence of adverse events associated with the administration of IV antibiotics; decreasing direct and indirect hospitalisation costs while improving patients’ comfort and mobility; and decreasing the risk of acquiring nosocomial infections. Certain elements are required to make the implementation of any guideline, including a switch therapy guideline, a success and probably one of the most important is the support from a motivated multidisciplinary team. The role of such a team, in the South African context, would be filled by the Pharmacy and Therapeutics Committee (PTC). In addition, to make a guideline successful it should be continuously implemented. This responsibility traditionally falls to a pharmacist. In the United Kingdom (UK) and the United States of America (USA) pharmacists are used to promote the appropriate use of antibiotics in hospitals as this has shown to have several economic advantages. The objectives of the study were: to determine, by means of a survey, whether guidelines for IV to oral switch were employed in South African regional, tertiary and national government hospitals; to design and implement an IV to oral antibiotic switch therapy (IVOST) guideline for a local public sector tertiary level hospital; to evaluate the effectiveness of guideline implementation; and to capture, via a questionnaire, the perceptions of prescribers regarding antibiotic prescribing, including switch therapy. The Survey of Current IV Switch Therapy Practice Questionnaire was distributed to Responsible Pharmacists at regional, provincial tertiary and national central government hospitals to determine whether IVOST guidelines were employed in South African government hospitals. Following the survey, an IVOST Guideline was designed by the researcher in consultation with the Department of Medicine and the Department of Pharmacy. The IVOST Guideline was implemented following approval by the PTC at a local tertiary level government hospital. A presentation was held for prescribers, guideline documents were distributed, posters were placed in the medical wards and the ward pharmacist/researcher integrated the guideline into daily practice by placing “reminder stickers” in patient medical folders. A pre-implementation audit and two post-implementation audits, each consisting of 150 patient medical records, were conducted and compared to determine the effect of IVOST guideline implementation on prescribing patterns and to determine whether any changes could be sustained. The Prescriber Antibiotic Survey was then conducted to capture the perceptions of prescribers regarding antibiotic therapy, including switch therapy.
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Whitaker, Paul. "Investigation into non-immediate hypersensitivity reactions to intravenous antibiotics in patients with cystic fibrosis." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613425.

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Antibiotic hypersensitivity represents a major clinical challenge in patients with cystic fibrosis (CF). Many patients have significant restrictions in antibiotic choice as a result of multiple previous hypersensitivity reactions; this often leads to suboptimal treatment. The majority of reactions are non-immediate and in similar cohorts of non-CF patients it has been demonstrated that they are T cell mediated. In this study we aimed to investigate the mechanism of hypersensitivity in a cohort of patients with CF and established hypersensitivity. As demonstrated in recent studies skin testing had low sensitivity in our cohort of patients. Only 13% of patients developed positive intradermal tests to piperacillin; no positives were seen with other beta-Iactams. In contrast, in-vitro Iymphocyte proliferation was seen in 68% of patients with piperacillin hypersensitivity. This is the first time drug specific Iymphocytes have been identified in patients with CF and supports the clinical viewpoint that the non-immediate reactions seen are T-cell mediated. Positive proliferation was also seen in patients with colistin hypersensitivity, including patients with neurological symptoms such as headache. Interestingly, the group of patients with neurological symptoms secondary to colistin also had positive drug specific IgG antibodies further supporting an immune mechanism. Whilst desensitisation is performed with some success at present it is not known whether any immune modulation takes place. The piperacillin model provides us with a useful tool to characterise the mechanisms of drug hypersensitivity and desensitisation. Prospective studies are needed to assess how drug sensitivity develops and whether clinical practice could be modified to reduce the risk.
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Brady, Patrick W. "Duration of intravenous antibiotics and treatment failure in infants hospitalized with urinary tract infections." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1299169787.

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Milbourne, Katrina Jane, and n/a. "A randomised controlled trial to investigate the efficacy of heparin and hydrocortisone additive to extend the life of peripheral cannulae in children." University of Canberra. Health Sciences, 2002. http://erl.canberra.edu.au./public/adt-AUC20050530.104945.

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Repeated cannulation of children during the course of treatment is distressing for the child, their family and to their nurses. Some paediatric units endeavour to minimise recannulation by employing strategies to reduce complications such as phlebitis and thrombosis formation. One strategy is to infuse low dose heparin and hydrocortisone (HEPHC). However, its effectiveness in prolonging cannula survival is inconclusive. There is also concern about the potential risks of administering these preparations to children. A randomised, controlled, blinded trial was conducted that examined the effectiveness of continuous infusion of low dose HEPHC in a group of children requiring long term intravenous antibiotics in a general paediatric unit. Comparisons of cannula complications and cannulae survival times were made in children receiving either continuous infusions of clear fluids or low dose HEPHC. The results demonstrated that there was no statistically significant difference (Logrank statistic=l.l, p=0.3) in cannula survival times between the two groups. It was also found that the bacterial and fungal colonisation of cannula for these children was extremely low. Based on these findings it is recommended that routine administration of low dose HEPHC to extend cannula survival time be discontinued. The findings also support current practice of removing cannula in children only when a complication occurs on completion of treatment.
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Bengtsson, Fatou, and Karin Reis. "Sjuksköterskors uppfattningar om risker vid arbete med intravenös antibiotika." Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-35471.

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Bakgrund: Inom hälso- och sjukvården kan personal råka ut för olika arbetsrelaterade besvär. Sjuksköterskan kommer i kontakt med många olika typer av läkemedel. Alla läkemedel är inte harmlösa för dem som iordningställer och administrerar dem. Då företagssköterskan ska arbeta hälsofrämjande och preventivt är det intressant att belysa sjuksköterskors arbete med intravenös antibiotika. KASAM kan vara till hjälp, på en arbetsplats, för att ta reda på vad som krävs för att kunna bevara men också förbättra hälsan hos medarbetarna.  Syfte: Att beskriva sjuksköterskors uppfattningar om risker vid arbete med intravenös antibiotika. Metod: Vald metod var kvalitativ metod. Fenomenografisk ansats användes vid analys av nio intervjuer. Resultat: Resultatet sammanfattades i tre beskrivningskategorier: Påverkan på kroppen, Utrustningens betydelse och Synliggöra risker. Slutsatser: Studiens resultat visar att sjuksköterskor är i behov av information om risker vid arbete med intravenös antibiotika. En ökad medvetenhet om riskerna kan bidra till att minska utvecklingen av både känd och icke känd överkänslighet samt minska resistensutvecklingen.
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Zacchi, Marianne Amada. "Avaliação da eficácia de programa de terapia sequencial de antimicrobiano em hospital oncológico." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-06022017-161855/.

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INTRODUÇÃO: Tem havido um crescente interesse em desenvolver programas para oferecer cuidados em casa para as condições que têm sido tradicionalmente tratadas nos hospitais, impulsionado por uma série de fatores, incluindo considerações de custo, a preferência do paciente e o aumento do risco de infecções adquiridas no hospital. As infecções são uma importante causa de internação e os antimicrobianos estão entre os fármacos mais comumente prescritos, o uso inadequado e disseminado está associado ao aparecimento de patógenos resistentes. Na oncologia os pacientes constituem um grupo sob especial risco de infecções. Estudos específicos sobre conversão de antimicrobianos em oncologia não são facilmente encontrados na literatura. OBJETIVO: Avaliar a eficácia do protocolo de um programa de terapia sequencial de antimicrobiano em hospital referência em oncologia. MÉTODO: Estudo retrospectivo de avaliação de intervenção, realizado em internação de um instituto de alta complexidade em oncologia, no período de maio de 2011 a maio de 2012, com etapa observacional pré-intervenção, e etapa de intervenção com aplicação do protocolo de terapia sequencial, onde ocorre a substituição do mesmo antimicrobiano de via intravenosa para a via oral. RESULTADOS: Foram incluídos 889 pacientes, 357 no período pré-intervenção e 532 no período de intervenção. Não houve diferença estatisticamente significativa na proporção de trocas entre os grupos pré-intervenção e intervenção, 33,61% e 37,59% respectivamente (OR 1,19, IC95% 0,90-1,58, p 0,23). Porém houve diferença para uso de levofloxacino, com maior chance de troca no grupo de intervenção (OR 2,94, IC95% 1,58-5,58, p 0,008). A neoplasia de mama como diagnóstico oncológico também foi associada a maior chance de troca (OR 2,10 IC95% 1,04-4,23, p 0,04). CONCLUSÃO: A implementação de protocolo de um programa de terapia sequencial em pacientes oncológicos em regime de internação não demonstrou impacto na troca de antimicrobiano IV para VO. Entretanto, resultou em maior chance de troca quando aplicada nos casos do uso de levofloxacino e naqueles cujo diagnóstico oncológico era neoplasia de mama
INTRODUCTION: There has been a growing interest in developing programs to provide home care for some conditions that have traditionally been treated in hospitals due to a number of factors, including cost considerations, the patient\'s preferences and the increased risk of infections acquired in the hospital. Infections are a major cause of hospitalization and the antimicrobials are among the most commonly prescribed drugs, their improper and widespread use is associated with the emergence of resistant pathogens. Oncology patients constitute a group at particular risk of infections. Specific studies on conversion of antimicrobial agents in Oncology are not easily found in the literature. OBJECTIVE: to evaluate the effectiveness of a program of sequential antimicrobial therapy in an Oncology hospital. METHOD: Retrospective study of intervention evaluation, conducted in hospitalized patients in an Oncology Institute from May 2011 to May 2012, with an observational pre-intervention step as well as a step of intervention with application of sequential therapy protocol, where the same antimicrobial is administered orally instead of via IV. RESULTS: Eight hundred and eighty-nine patients were included, 357 in the pre-intervention phase and 532 in the intervention phase. There was no statistically significant difference in the proportion of changing between the pre-intervention and intervention groups, 33.61% and 37.59% respectively (OR 1.19, IC95% 0.90-1.58, p 0.23). But there was difference for the use of levofloxacin, with greater chance of switching in the intervention group (OR 2.94, IC95% 1.58-5.58, p 0.008). The breast cancer diagnosis was also associated with greater chance of switching (OR 2.10 IC95% 1.04-4.23, p 0.04). CONCLUSION: The implementation of a protocol of a sequential therapy program in oncology patients in inpatient regime showed no impact on antimicrobial switch from IV to VO. However, it resulted in higher chance of switch when applied in cases of use of levofloxacin and in those whose cancer diagnosis was breast neoplasm
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Dryburgh, Leslie Irene. "A retrospective study of the diagnostic and treatment practices of health care professionals for patients receiving out-patient intravenous antibiotic therapy for cellulitis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ56120.pdf.

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Grigoletto, Renan. "Avaliação da concentração intra-articular de gentamicina, associada ou não ao DMSO, administrada por perfusão regional intravenosa em membro de equinos sadios." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/74/74135/tde-02022016-095030/.

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Dentre as afecções que acometem as articulações dos equinos, a artrite séptica e a mais grave observada. A técnica da perfusão regional e um método comprovadamente eficiente para o tratamento de equinos acometidos por infecções sinoviais. O dimetilsulfóxido (DMSO) é um líquido orgânico, que possui a capacidade de penetrar, com extrema facilidade, em órgãos, tecidos e membranas celulares e intracelulares. Neste estudo, objetivou-se avaliar a concentração intra-articular da gentamicina administrada por perfusão regional intravenosa (PRI), associada ou não ao DMSO, bem como avaliar a influência do volume total perfundido o período de tempo onde a concentração inibitória mínima (CIM) foi mais eficiente e se a associação com o DMSO aumentou a CIM no líquido sinovial. Os animais foram distribuídos em quatro grupos experimentais, cada grupo recebeu gentamicina 6,6 mg/kg por PRI, o volume a ser administrado, após o cálculo da quantidade de gentamicina acrescida ou não de DMSO, era completado com solução de ringer com lactato estéril até o volume de 60mL nos grupos G60 e GD60, e até 250mL para os grupos G250 e GD250. As colheitas de líquido sinovial foram realizadas antes do início do experimento (T0), imediatamente depois da retirada do torniquete (T1) e após 4 (T2), 8 (T3), 12 (T4), 16 (T5) e 24 (T6) horas. O método para doseamento das concentrações de gentamicina empregado foi o de difusão em ágar. Destacamos que as concentrações de gentamicina no líquido sinovial na dose de 6.6.mg/Kg podem ser consideradas como adequadas, num período de até 24 horas após a administração. Nossos resultados apontam que o volume de 60 mL, pode ser considerado como o volume ideal de perfusão, bem como a associação do DMSO aumentou as concentrações de gentamicina (µg/mL) na articulação dos equinos e possivelmente reduziu a formação de edemas e aumentos de volume locais.
Among the diseases that affect the joints of horses, septic arthritis is the most serious observed. The regional perfusion technique is a well proven method for the treatment of horses affected by synovial infections. Dimethylsulfoxide (DMSO) is an organic liquid that has the ability to penetrate, with extreme ease on organs, tissues and cellular and intracellular membranes. This study aimed to evaluate the intra-articular concentration of gentamicin administered by intravenous regional perfusion (PRI), associated or not with DMSO, and assess the influence of the total volume infused the time period in which the minimum inhibitory concentration (MIC) It was more efficient and the association with DMSO increased the CIM in the synovial fluid. The animals were divided into four groups, each group received 6.6 mg gentamicin / kg per PRI, the volume to be administered, after calculating the amount of gentamicin plus or absence of DMSO was completed with Ringer\'s lactate solution with sterile until the volume in 60mL groups G60 and GD60, and up to 250 mL and G250 GD250 groups. The synovial fluid samples were collected before the start of the experiment (T0), immediately after removal of the tourniquet (T1) and after 4 (T2), 8 (T3), 12 (T4), 16 (T5) and 24 (T6) hours. The method for determination of gentamicin concentrations was employed the agar diffusion. We emphasize that the gentamicin concentrations in synovial fluid in 6.6.mg/Kg dose may be considered suitable, a period of up to 24 hours after administration. Our results indicate that the volume of 60 ml, can be considered as the ideal volume of the infusion, as well as the association of DMSO increased the gentamicin concentrations (µg / ml) in the joint of horses and possibly reduced edema formation and increases local volume.
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Varescon, Jean-Pascal Marie Dieudonné [Verfasser], Thomas O. F. [Akademischer Betreuer] Wagner, Thomas O. F. [Gutachter] Wagner, and Stefan [Gutachter] Zielen. "Comparison of surrogate parameters of prognosis (BMI, FEV1 and need of intravenous antibiotic therapy) between CF-patients with and without P. aeruginosa in Frankfurt and Moscow from 1990 to 2015 / Jean-Pascal Marie Dieudonné Varescon ; Gutachter: Thomas O. F. Wagner, Stefan Zielen ; Betreuer: Thomas O. F. Wagner." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2021. http://d-nb.info/1239143818/34.

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Chang, Hsiao-Wei, and 張曉維. "Outcomes of adjunctive aerosolized aminoglycosides in intravenous antibiotics therapy for Pseudomonas aeruginosa pneumonia." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/te654w.

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碩士
高雄醫學大學
藥學系碩士在職專班
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Background: It is common that pneumonia of the ICU in Taiwan is caused by Pseudomonas aeruginosa. Due to the abuse of antibiotic prescription, the resistance of Pseudomonas aeruginosa is increasing. The previous study shows that when treating pulmonary infection, inhaled antibiotics yields higher pulmonary concentrations than intravenous administration. Whether the follow up efficacy also increased with the higher pulmonary antibiotic concentration is yet to be proven by evidence. Study design, location and subjects: This study was conducted south of a regional teaching hospital for the single-center, retrospective study of medical records. The study objects are those age between 20 and 99 years old, infected with Pseudomonas aeruginosa pneumonia in ICU and confirmed by bacterial culture from January 1st 2010 to December 31th 2013. Based on treatment methods, patients are divided into two groups, one is given antibiotics by intravenous route only and the other group is given intravenous and inhaled antibiotics in combination. Methods: All patients’ basic information and clinical data are collected by chart review. Clinical data are divided by timeline and recorded days of patients’ ICU stay, days of ventilation patient use, improvement of clinical symptoms of pneumonia and the incidence of drug-resistant bacteria, etc. Use Acute Physiology and Chronic Health Evaluation Score and Clinical Pulmonary Infection Score as assessment tool. The endpoint is mortality of 30 days after infection and all data undergo statistical analysis and comparison. Statistical analysis includes chi-square test (χ2 test), T test (t-test), and Fisher exact test (Fisher''s exact test). Results: During the study period from January 1st 2010 to December 31th 2013, a total of 67 patients were included, 44 of them used monotherapy (intravenous antibiotics alone) and 23 of then used combination therapy(intravenous and inhaled antibiotics). The patients information showed that the average age was 76.5 years old(standard deviation 13.9), male to female ratio was 71.6% to 28.4%. In comparison between the two group, other than male percentage in monotherapy group (p-0.047), there were no significant differences between the two group before treatment in age, Acute Physiology and Chronic Health Evaluation score, Clinical Pulmonary Infection Score, renal function, other infection site. More than 80 percent of patients'' age in both groups were over 60. After treatment, there were no significant difference in days of ICU stays (p= 0.452), days or ventilator use (p= 0.061), days of intravenous injection of antibiotics(p= 0.066), Acute Physiology and Chronic Health Evaluation score (p= 0.589), difference of Clinical Pulmonary Infection Scale before and after treatment (p= 0.078), ratio of elevated creatinine value more than 1(p= 0.523), re-cultured Pseudomonas aeruginosa (p= 0.46), cultured drug-resistance Pseudomonas aeruginosa(p= 0.603), or 30-day mortality(p= 0.308). Conclusions: In comparison of monotherapy with combination therapy, the latter posed no effect on renal function but yielded not significantly difference regarding symptoms of pneumonia, days of intravenous injection, days of ICU stays, Acute Physiology and Chronic Health Evaluation score when leaving ICU, re-infected rate of Pseudomonas aeruginosa, or drug resistance strains. Due to our study was a chart review retrospective one, there were more limitation comparing to prospective study with respect to strict protocol. Therefore our study was not representative of the entire patient populations. To clear all predictive variables, the best method was still prospective trials available to control various of confounding factors.
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Books on the topic "Intravenous antibiotics"

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Yau, Marina. A home intravenous antibiotic program for cystic fibrosis patients. London: Victoria Hospital, 1987.

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Milkovich, Natalie Christine. An economic evaluation of hospital-based and home-based intravenous antibiotic therapy for individuals with cellulitis. Ottawa: National Library of Canada, 2002.

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Gilchrist, Francis J., and Alex Horsley. Management of respiratory exacerbations. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198702948.003.0005.

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Cystic fibrosis lung disease is characterized by chronic infection, inflammation and a progressive loss of lung function. Patients are also affected by recurrent episodes of increased respiratory symptoms, called exacerbations which have a detrimental effect on quality of life, the rate of lung function decline, and mortality. Early diagnosis and treatment is vital. Diagnosis relies on a combination of symptoms, examination findings, the results of laboratory tests, and lung function. Antibiotics are the mainstay of treatment but airway clearance, nutrition, and glucose homeostasis must also be optimized. Mild exacerbations are usually treated with oral antibiotics and more severe exacerbations with intravenous antibiotics. The choice of antibiotic is guided by the patient’s chronic pulmonary infections, the in-vitro antibiotic sensitivities, known antibiotic allergies, and the previous response to treatment. In patients with chronic Pseudomonas aeruginosa infection, antibiotic monotherapy is thought to increase the risk of resistance and treatment with 2 antibiotics is therefore suggested (usually a β‎-lactam and an aminoglycoside). Although there is a lack of evidence on the duration of treatment, most patients receive around 14 days. This can be altered according to the time taken for symptoms and lung function to return to pre-exacerbation levels. If patients are carefully selected and receive appropriate monitoring, home intravenous antibiotics can be as effective as in-patient treatment. They are also associated with decreased disruption to patients / family life, decreased risk of cross infection and decreased costs.
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Gertz, Alida. Tularemia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0067.

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Tularemia, caused by the gram-negative coccobacillus Francisella tularensis, is an extremely infectious bacterial zoonosis. Symptoms depend on site of exposure; they can be nonspecific and may include fever, lymphadenopathy, ulcer or papule, and nausea/vomiting. Natural transmission occurs via small mammals, such as rabbits, or arthropod bites. IV or IM antibiotics are preferred over oral forms. Supportive care is also critical; some patients may require respiratory support. If used as a biological weapon, aerosolized F. tularensis would be the most likely route of transmission. Clinical symptoms would include those of pneumonic tularemia. In the event of a bioterrorist attack, oral administration antibiotics can be used, as the health care system may not be able to accommodate intravenous or intramuscular treatment. Antibiotic resistance should also be considered if patients deteriorate despite use of recommended antibiotics.
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Saha, Sudip. Septic Thrombophlebitis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0021.

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Septic (suppurative) thrombophlebitis is venous thrombosis in the setting of bacteremia. There is usually a degree of perivascular inflammation seen on histology. Septic thrombophlebitis occurs most commonly with intravenous catheters. However, most cases of infection related to intravenous catheters are not complicated by septic thrombophlebitis. Catheter-related septic thrombophlebitis includes erythema, tenderness, and/or drainage at the site of an intravenous catheter. Jugular vein septic thrombophlebitis, also known as Lemierre’s syndrome, is a subset of septic thrombophlebitis. This condition can affect otherwise young, healthy adults and is often preceded by pharyngitis with tonsillar and peritonsillar involvement, dental infections, or infectious mononucleosis. Presentation of jugular vein septic thrombophlebitis includes high fevers, rigors, respiratory distress, ulceration or erythema of the oropharynx, and tenderness and swelling of the neck. Primary treatment of thrombophlebitis includes removal of infected materials, intravenous antibiotics, and possible anticoagulation.
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Sevransky, Jon. Management of sepsis in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0296.

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Sepsis is triggered by an infection, and treatment of sepsis requires timely identification of the patient, and rapid treatment with antibiotics, source control, and fluids. The site of infection, patient’s phenotype, and location of the patient will help drive decisions about initial antibiotic therapy. Patients with sepsis should be treated to ensure adequate cardiac output and organ perfusion, which usually requires infusion of intravenous fluids. In addition to haemodynamic and fluid support, some patients require infection source control. Many sepsis patients require additional supportive therapy with vasoactive agents, mechanical ventilation, renal replacement therapy, and nutritional therapy.. When using these supportive therapies, the clinician should attempt to minimize the complications of the therapies, including withdrawal of therapies that are no longer necessary.. Patients who do not respond to initial therapy should be evaluated for resistant organisms, persistent sources, or alternate diagnoses.
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P, Davey, and Clinical Resource and Audit Group., eds. Audit of intravenous antibiotic administration. (Edinburgh): Scottish Office, 1992.

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McGregor, Laura, Monica N. Gupta, and Max Field. Septic arthritis in adults. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0098.

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Septic arthritis (SA) is a medical emergency with mortality of around 15%. Presentation is usually monoarticular but in more than 10% SA affects two or more joints. Symptoms include rapid-onset joint inflammation with systemic inflammatory responses but fever and leucocytosis may be absent at presentation. Treatment according to British Society of Rheumatology/British Orthopaedic Association (BSR/BOA) guidelines should be commenced if there is a suspicion of SA. At-risk patients include those with primary joint disease, previous SA, recent intra-articular surgery, exogenous sources of infection (leg ulceration, respiratory and urinary tract), and immunosupression because of medical disorders, intravenous drug use or therapy including tumour necrosis factor (TNF) inhibitors. Synovial fluid should be examined for organisms and crystals with repeat aspiration as required. Most SA results from haematogenous spread-sources of infection should be sought and blood and appropriate cultures taken prior to antibiotic treatment. Causative organisms include staphylococcus (including meticillin-resistant Staphylococcus aureus, MRSA), streptococcus, and Gram-negative organisms (in elderly patients), but no organism is identified in 43%, often after antibiotic use before diagnosis. Antibiotics should be prescribed according to local protocols, but BSR/BOA guidelines suggest initial intravenous and subsequent oral therapy. Medical treatment may be as effective as surgical in uncomplicated native SA, and can be cost-effective, but orthopaedic advice should be sought if necessary and always in cases of infected joint prostheses. In addition to high mortality, around 40% of survivors following SA develop limitation of joint function. Guidelines provide physicians with treatment advice aiming to limit mortality and morbidity and assist future research.
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Spevetz, Antoinette, and Joseph E. Parrillo. Diagnosis and management of shock in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0150.

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Sepsis is triggered by an infection and treatment of sepsis requires timely identification of the patient, and rapid treatment with antibiotics, source control, and fluids. In the absence of a true biomarker for sepsis, the clinician needs to recognize which patients are at risk, as well as the common signs and symptoms of infection. The site of infection, the patient’s phenotype, and the location of the patient will help drive decisions about initial antibiotic therapy. Patients with sepsis should be treated to ensure adequate cardiac output and organ perfusion, which usually requires infusion of intravenous fluids. Crystalloid fluids are most frequently infused, and patients will often require large doses in the first 6–24 hours of treatment. In addition to haemodynamic and fluid support, some patients require infection source control. Many sepsis patients require additional supportive therapy with vasoactive agents, mechanical ventilation, renal replacement therapy, and nutritional therapy. The use of these supportive therapies allows for a patients host defence system to work in conjunction with antibiotics to fight off the infection. When using these supportive therapies, the clinician should attempt to minimize the complications of the therapies and the causative infection. Once a patient starts to clinically improve, it is essential that therapies that are no longer necessary are withdrawn. Patients who do not respond to initial therapy should be evaluated for either resistant organisms, persistent sources, or alternate diagnoses.
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Wijdicks, Eelco F. M., and Sarah L. Clark. Drugs Used to Prevent Complications. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190684747.003.0017.

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Comprehensive neurosciences nursing care goes far in providing optimal support, but the acute immobilization and anticipated prolonged bed rest requires the use of prophylactic drugs. Many options relate to failure to move limbs, failure to breathe adequately and placement of intravenous catheters This chapter covers the more critical preventive measures.Prevention of deep venous thrombosis, hyperglycemia, stress ulcers, ventilator-associated pneumonia, urinary tract infections, vascular access infections, ventriculitis, and post-craniotomy infections are discussed in this chapter. Pharmacists assist in effective stewardship and surveillance of critically ill patients by helping select the appropriate antibiotics, determining the need for drug levels, and initiating or stopping preventative medications.
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Book chapters on the topic "Intravenous antibiotics"

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Craig, John, and Parul Goyal. "Topical and Intravenous Antibiotics." In Practical Medical and Surgical Management of Chronic Rhinosinusitis, 253–65. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16724-4_14.

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Ruskin, Claire. "Intravenous antibiotics at home: a parents’ perspective." In Evidence-based Child Health Care, 346–58. London: Macmillan Education UK, 2000. http://dx.doi.org/10.1007/978-0-333-98239-6_19.

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Brown, Richard B. "Home Intravenous Antibiotic Therapy." In Infections in Outpatient Practice, 229–40. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-0780-6_19.

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Williams, D. N. "Home Intravenous Antibiotic Therapy: New Technologies." In Supportive Care in Cancer Patients II, 215–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-84138-5_25.

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Ronan-Bentle, Sarah. "What Are the Goals of Resuscitation in the ED? What Intravenous Fluids Should Be Used? Are Vasopressors Beneficial or Harmful? Should Antibiotics Be Administered?" In Gastrointestinal Emergencies, 107–8. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-98343-1_32.

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van der Deure, J., and J. A. E. van Wijk. "Wanneer moeten antibiotica intraveneus worden toegediend bij kinderen met pyelonefritis?" In Vademecum permanente nascholing huisartsen, 2289–90. Houten: Bohn Stafleu van Loghum, 2006. http://dx.doi.org/10.1007/978-90-313-8808-0_1206.

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"VANCOMYCIN-(Intravenous Only)." In Antibiotics Manual, 403–4. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119220787.ch185.

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"2 Antibiotics for Orthopaedic Infections." In Management of Orthopaedic Infections, edited by Antonia F. Chen. New York, NY: Thieme Medical Publishers, Inc., 2021. http://dx.doi.org/10.1055/b-0041-181977.

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Antibiotics play a critical role in the treatment of bone and joint infections. In clinical practice, antibiotics may be delivered intravenously, orally, or topically, alone or as part of a delivery mechanism. This chapter will discuss the most commonly used oral and intravenous antibiotics in orthopaedic infections, their efficacy and bioavailability, and important considerations when using these antibiotics for patient care. This chapter will additionally focus on the use of topical antibiotics and nondegradable/biodegradable carriers for antibiotic delivery, such as the use of heat-stable antibiotics in cement spacers. The information presented here is designed for use as a clinical reference to provide guidance on the care of patients with orthopaedic infections including osteomyelitis, septic joints, and periprosthetic joint infections.
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Penman, Alan D., Kimberly W. Crowder, and William M. Watkins. "Immediate Vitrectomy and Intravenous Antibiotics for the Treatment of Postoperative Bacterial Endophthalmitis." In 50 Studies Every Ophthalmologist Should Know, 207–12. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780190050726.003.0034.

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The Endophthalmitis Vitrectomy Study (EVS) was a randomized, controlled clinical trial to determine the roles of immediate pars plana vitrectomy and systemic antibiotic treatment in the management of postoperative endophthalmitis in patients with clinical signs and symptoms of bacterial endophthalmitis within 6 weeks of cataract surgery or secondary intraocular lens (IOL) implantation and visual acuity between 20/50 and light perception. The study found that routine immediate pars plana vitrectomy is not necessary in patients with better than light perception vision at presentation but is of substantial benefit for those who have light perception-only vision (or worse). Most patients do not require treatment with intravenous antibiotics. Omission of systemic antibiotic treatment can reduce toxic effects, costs, and length of hospital stay.
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Adam, Dieter, and Friedrich Englert. "Interactions During the Administration: Direct Interaction of Antibiotics Through Contact During Intravenous Perfusion." In Useful and Harmful Interactions of Antibiotics, 27–110. CRC Press, 2019. http://dx.doi.org/10.1201/9780429279744-2.

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Conference papers on the topic "Intravenous antibiotics"

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Sneller, Sarah, and Bethany Wright. "115 Experience of using intravenous antibiotics in an inpatient hospice unit." In The APM’s Supportive & Palliative Care Conference, Accepted Oral and Poster Abstract Submissions, The Harrogate Convention Centre, Harrogate, England, 21–22 March 2019. British Medical Journal Publishing Group, 2019. http://dx.doi.org/10.1136/bmjspcare-2019-asp.138.

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Anning, Louise, Mhairi McNeill, Alexander Rose, Hilary Mortimer, and Nicholas Withers. "The use of home intravenous antibiotics in adult non-CF bronchiectasis." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa2626.

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Ortiz Latorre, JL, MD Toscano Guzmán, M. Gómez Delgado, and I. Moya Carmona. "5PSQ-026 Impact of the early switching from intravenous to oral antibiotics in a tertiary hospital." In 25th EAHP Congress, 25th–27th March 2020, Gothenburg, Sweden. British Medical Journal Publishing Group, 2020. http://dx.doi.org/10.1136/ejhpharm-2020-eahpconf.343.

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Shearer, M., K. Andrassy, H. Bechtold, P. McCarthy, J. Koderisch, and H. Koderisch. "CEPHALOSPORIN-INDUCED HYPOPROTHROMBINAEMIA: RELATION TO CEPHALOSPORIN SIDE CHAIN, VITAMIN K METABOLISM AND VITAMIN K STATUS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643076.

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An increased incidence of bleeding episodes due to hypopro-thrombinaemia has been associated with several cephalosporins especially those which contain an N-methyl-thio-tetrazole (NMTT) side chain. To study the etiology of cephalosporin-induced hypo-prothrombinaemia in the clinical situation we have investigated the ability of different cephalosporins to alter the metabolism of vitamin K and the relationship between hypoprothrombinaemia and vitamin K status as assessed from plasma levels of vitamin K. Cephalosporins containing an NMTT side chain (latamoxef, cefmenoxime, cefoperazone, cefotetan, cefamandole) or related structure (cefozolin) all caused the transient plasma appearance of vitamink1 2,3-epoxide in response to a 10 mg intravenous dose of vitamin ; those without NMTT (cefotaxime and cefoxitin) did not. The plasma accumulation of vitamin k1 2,3-epoxide was qualitatively similar to, but quantitatively less than, that produced by the oral anticoagulant phenprccoumon. In 36 patients eating normally, the median endogenous plasma vitamin k1 (370 pg/ml) was not significantly different from that in healthy, fasting subjects (372 pg/ml) and clotting tests remained consistently normal for all antibiotics tested. In 22 patients on total parenteral nutrition the median plasma vitamin k1. (223 pg/ml) was significantly lower than normal (p < 0.01) with 61patients having levels below the normal range (< 150 pg/ml) but normal clotting before starting antibiotic therapy. All 7 parenterally-fed patients treated with latamoxef developed hypoprothrombinaemia (as shown by prothrombin time, PIVKA-II and protein C measurements) within 4 days whereas 12 patients treated with cefotaxime or cefoxitin did not. Latamoxef-associated hypoprothrombinaemia was readily reversible by 1 mg of vitamin k1 given intravenously but hypoprothrombinaemia and sub-normal plasma vitamin k1 could recur within 2-3 days. The data suggest that NMTT-cephalosporins are inhibitors of hepatic vitamin K epoxide reductase and that a lowered vitamin K status predisposes to hypoprothrombinaemia.
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McKerr, Caroline, Adam Massey, Geraldine Lynch, and Nabil Jarad. "Factors associated with the need of intravenous antibiotics in a cohort of adult patients with non-CF bronchiectasis." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa2679.

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Echeverria-Esnal, D., J. Martinez-Casanova, M. Dominguez-Alvarez, C. Estirado, MP Ausin, E. Balcells, C. Martin-Ontiyuelo, et al. "4CPS-067 Effectiveness and safety of the early switch from intravenous to oral antibiotics treatment in the pneumology ward." In 24th EAHP Congress, 27th–29th March 2019, Barcelona, Spain. British Medical Journal Publishing Group, 2019. http://dx.doi.org/10.1136/ejhpharm-2019-eahpconf.216.

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Shappell, C., M. Klompas, and C. Rhee. "Diagnostic Uncertainty in Patients Empirically Treated with Intravenous Broad-Spectrum Antibiotics in the Emergency Department: A Retrospective Cohort Study." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3495.

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Scanlan, BT, LF Ibrahim, SM Hopper, S. McNab, S. Donath, FE Babl, A. Davidson, and PA Bryant. "G122(P) Intravenous or oral antibiotics for urinary tract infection/pyelonephritis in children? Development of the melbourne rupert score." In Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference and exhibition, 13–15 May 2019, ICC, Birmingham, Paediatrics: pathways to a brighter future. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-rcpch.118.

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Woods, SJ, and A. Kumar. "G225(P) Meows (modified early obstetric warning scores) can reduce the number of asymptomatic babies treated with intravenous (IV) antibiotics at birth." In Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference and exhibition, 13–15 May 2019, ICC, Birmingham, Paediatrics: pathways to a brighter future. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-rcpch.220.

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Collaco, Joseph M., Deanna M. Green, Peter Mogayzel, Kathleen M. Naughton, and Garry R. Cutting. "Intravenous Antibiotics And Cystic Fibrosis Respiratory Exacerbations: Hospital Therapy Is Equivalent To Home Therapy And 5-10 Days May Be The Optimal Treatment Length." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1811.

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Reports on the topic "Intravenous antibiotics"

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Keren, Ron, Russell Localio, Shawn Rangel, Samir Shah, and Srivastava Srivastava. Comparative Effectiveness of Intravenous vs. Oral Antibiotic Therapy for Serious Bacterial Infections. Patient-Centered Outcomes Research Institute (PCORI), November 2018. http://dx.doi.org/10.25302/11.2018.cer.526.

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Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis. National Institute for Health Research, January 2018. http://dx.doi.org/10.3310/signal-000543.

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Switching to oral antibiotics early for bone and joint infections gave similar results to continuing intravenous therapy. National Institute for Health Research, April 2019. http://dx.doi.org/10.3310/signal-000760.

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