Relevant bibliographies by topics / Intraoperative cancer diagnostics

Academic literature on the topic 'Intraoperative cancer diagnostics'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Intraoperative cancer diagnostics"

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Rzepakowska, Anna. "Modern diagnostics of early glottic cancer." Polski Przegląd Otorynolaryngologiczny 9, no. 4 (December 7, 2020): 1–5. http://dx.doi.org/10.5604/01.3001.0014.5706.

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This article is a review of literature and a summary of the current guidelines in the diagnosis of hypertrophic vocal folds suspected of malignancy. It gives a detailed overview both of initial diagnosis, as well as the methods of in-depth intraoperative diagnostics and proposals for careful evaluation during post-treatment follow-up examinations.
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Putova, M. V., K. K. Noskova, B. A. Pomortsev, N. E. Semenov, and R. E. Izrailov. "CYTOLOGICAL DIAGNOSTICS OF INTRAOPERATIVE PERITONEAL WASHES IN GASTRIC CANCER." Russian Clinical Laboratory Diagnostics 64, no. 4 (October 7, 2019): 225–28. http://dx.doi.org/10.18821/0869-2084-2019-64-4-225-228.

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Diagnosis of peritoneal microcanceromatosis is the most important task allowing to determine treatment strategy for patients with stomach cancer. Laparoscopy combined with peritoneal flushing and subsequent cytological examination should be performed to detect the peritoneal microcanceromatosis at the preoperative stage. The objective of this work was to improve cytological diagnostics of peritoneal washings using immunocytochemical techniques and the cell block method. The work was carried out on the basis of 276 surgical peritoneal washings in patients with stomach cancer who were on treatment in the department of high-tech surgery of the Moscow Clinical Scientific Centre of the State Budgetary Healthcare Institution named after Loginov A.S. from June 2016 to June 2018. As a result, the optimal panel of monoclonal antibodies (Ber-EP4, CEA, CK20) was chosen, which increased the sensitivity from 52% to 96% and the specificity of cytological diagnosis from 80% to 98%, and the overall accuracy of the method from 67% to 98%.
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Reshetov, I., E. Filonenko, A. Golubtsov, and E. Kirpa. "8584 POSTER Intraoperative Photodynamical Navigation in Thyroid Cancer Diagnostics." European Journal of Cancer 47 (September 2011): S568. http://dx.doi.org/10.1016/s0959-8049(11)72226-2.

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Saevets, V. V., A. Y. Shamanova, Y. A. Semenov, and A. V. Chizhovskaja. "Diagnostic possibilities and limitations of urgent intraoperative pathologicanatomical studies in oncogynecology." Ural Medical Journal 20, no. 2 (July 19, 2021): 8–13. http://dx.doi.org/10.52420/2071-5943-2021-20-2-5-11.

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Introduction. One of the variants of intravital pathological and anatomical diagnostics is intraoperative pathological and anatomical ("urgent") examination, which serves for tumor process verification. Urgent intraoperative pathological and anatomical examination is widely used when there are certain differential diagnostic difficulties and limitations of instrumental methods of examination.The purpose of the study — to analyze the possibilities, limitations and the accuracy of "urgent" pathologic and anatomical diagnostics in oncogynecological diseases. Materials and methods. We retrospectively analyzed medical records of 378 inpatients treated in the gynecologic oncology department of CHOKZO and NM for the period from January 2016 to January 2021. Results and discussion. Urgent histological examination was used to diagnose ovarian tumors (82%, n=310); to evaluate the extent of a tumor process in uterine body cancer, ovarian cancer, cervical cancer (peritoneal carcinomatosis, ingrowth into adjacent tissues and organs) (15%, n=57); less often to evaluate resection margin ablation in cervical cancer, uterine body cancer (3%, n=11). In a comparison of conclusions after urgent morphological examination and conduction of material, discrepancies were registered only in hypodiagnostic ovarian tumors (in 5.8% of all "urgent" ovarian tumor studies, n=18), when the question about the malignancy potential of a process cannot be reliably decided. The reliability of intraoperative morphological verification of the process is 94.2%. The sensitivity is 96%, specificity is 97%, which is consistent with the results of other studies. Conclusions. Intraoperative morphological diagnosis is a highly specific and highly sensitive method of investigation. There are limitations of this diagnostic method depending on the volume of tissue material, quality of cryostat sections, as well as tumor features (e.g., ovarian masses) consisting of heterologous morphological areas. A compliant, multidisciplinary approach is required to successfully meet the challenges of intraoperative examination.
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Farrakhova, Dina, Artem Shiryaev, Dmitry Yakovlev, Kanamat Efendiev, Yulia Maklygina, Alexandr Borodkin, Maxim Loschenov, et al. "Trials of a Fluorescent Endoscopic Video System for Diagnosis and Treatment of the Head and Neck Cancer." Journal of Clinical Medicine 8, no. 12 (December 17, 2019): 2229. http://dx.doi.org/10.3390/jcm8122229.

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This article presents the results of intraoperative fluorescent diagnostics via the endoscopic system for assessing the quality of photodynamic therapy (PDT) of head and neck cancer. The diagnosis and PDT procedures were performed on the five patients with malignant neoplasms of the vocal cords, lateral surface of the tongue, and trachea and cancer of the left parotid salivary gland. Molecular form of chlorin E6 (Ce6) was intravenously administered with a 1.0–1.1 mg/kg concentration for PDT. Fluorescent diagnostics (FD) was conducted before PDT and after PDT procedures. Control of PDT efficiency was carried out by evaluating the photobleaching of the drug (photosensitizer). The method of intraoperative fluorescent imaging allows determining the exact location of the tumor and its boundaries. The assessment of photosensitizer photobleaching in real time regime allows making quick decisions during PDT procedure, which helps improving the quality of patients’ treatment. The results showed the convenience of endoscopic fluorescent video system in various nosologies of head and neck cancer. Therefore, this diagnostic approach will improve the effectiveness of cancer treatment.
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SUN, JONATHAN G., STEVEN G. ADIE, ERIC J. CHANEY, and STEPHEN A. BOPPART. "SEGMENTATION AND CORRELATION OF OPTICAL COHERENCE TOMOGRAPHY AND X-RAY IMAGES FOR BREAST CANCER DIAGNOSTICS." Journal of Innovative Optical Health Sciences 06, no. 02 (April 2013): 1350015. http://dx.doi.org/10.1142/s1793545813500156.

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Pre-operative X-ray mammography and intraoperative X-ray specimen radiography are routinely used to identify breast cancer pathology. Recent advances in optical coherence tomography (OCT) have enabled its use for the intraoperative assessment of surgical margins during breast cancer surgery. While each modality offers distinct contrast of normal and pathological features, there is an essential need to correlate image-based features between the two modalities to take advantage of the diagnostic capabilities of each technique. We compare OCT to X-ray images of resected human breast tissue and correlate different tissue features between modalities for future use in real-time intraoperative OCT imaging. X-ray imaging (specimen radiography) is currently used during surgical breast cancer procedures to verify tumor margins, but cannot image tissue in situ. OCT has the potential to solve this problem by providing intraoperative imaging of the resected specimen as well as the in situ tumor cavity. OCT and micro-CT (X-ray) images are automatically segmented using different computational approaches, and quantitatively compared to determine the ability of these algorithms to automatically differentiate regions of adipose tissue from tumor. Furthermore, two-dimensional (2D) and three-dimensional (3D) results are compared. These correlations, combined with real-time intraoperative OCT, have the potential to identify possible regions of tumor within breast tissue which correlate to tumor regions identified previously on X-ray imaging (mammography or specimen radiography).
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Xu, Jian, David Kooby, Brad Kairdolf, and Shuming Nie. "New horizons in intraoperative diagnostics of cancer in image and spectroscopy guided pancreatic cancer surgery." European Journal of Molecular & Clinical Medicine 1 (September 7, 2017): 2. http://dx.doi.org/10.1016/j.nhccr.2017.06.139.

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Pirro, V., A. K. Jarmusch, C. M. Alfaro, E. M. Hattab, A. A. Cohen-Gadol, and R. Graham Cooks. "Utility of neurological smears for intrasurgical brain cancer diagnostics and tumour cell percentage by DESI-MS." Analyst 142, no. 3 (2017): 449–54. http://dx.doi.org/10.1039/c6an02645a.

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Yang, Lingxiao, Jaena Park, Marina Marjanovic, Eric J. Chaney, Darold R. Spillman, Heidi Phillips, and Stephen A. Boppart. "Intraoperative Label-Free Multimodal Nonlinear Optical Imaging for Point-of-Procedure Cancer Diagnostics." IEEE Journal of Selected Topics in Quantum Electronics 27, no. 4 (July 2021): 1–12. http://dx.doi.org/10.1109/jstqe.2021.3054578.

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Rumyantsev, P. O., A. A. Bubnov, P. V. Sviridov, P. A. Nikiforovich, A. A. Trukhin, and S. V. Korenev. "MOLECULAR IMAGING AND INTRAOPERATIVE RADIONAVIGATION IN PROSTATE CANCER." Siberian journal of oncology 20, no. 4 (August 30, 2021): 108–15. http://dx.doi.org/10.21294/1814-4861-2021-20-4-108-115.

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Introduction. Prostate cancer is one of the most common malignant neoplasms. Strategies to improve early diagnosis and subsequent therapy are being improved. An emphasis is placed on maintaining the quality of life and working capacity of patients after treatment. This can be achieved by improving methods of focal therapy, which depends on the accuracy of topical diagnosis and classification of the tumor. Hybrid molecular imaging (pet/ct and spect/ct) is used in addition to the methods of structural imaging (ultrasound, ct, mri). Intraoperative imaging using radionavigation systems is also used in open and endoscopic surgery for prostate cancer. Currently, it is a tool capable of reducing the invasiveness of surgery, localizing the area of metastatic lesions with a sensitivity and specificity of up to 95 %.Objective of the study: an overview of current and promising future methods of intraoperative radio navigation in the surgical treatment of prostate cancer.Material and methods. The review presents the methods of intraoperative radionavigation in the surgical treatment of prostate cancer. Radionavigation in the context of using tumarotropic radiopharmaceutical based on a prostate-specific membrane antigen, in which the drug accumulates in all tumor foci expressing this receptor, is also considered.Conclusion. The use of preoperative hybrid imaging and radio-guided surgery facilitate lesion identification and resection. Gamma probing allows detection of psma-positive tumor foci regardless of their depth. Fluorescence imaging methods (icg, photodynamic diagnostics, autofluorescence) are also used for intraoperative detection of pathological foci in real time. Multichannel gamma probing and cherenkov radiation detection, which combine the advantages of indirect and direct intraoperative imaging, have enormous potential.
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Dissertations / Theses on the topic "Intraoperative cancer diagnostics"

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(6597242), Clint M. Alfaro. "DEVELOPMENT OF AMBIENT IONIZATION MASS SPECTROMETRY FOR INTRAOPERATIVE CANCER DIAGNOSTICS AND SURGICAL MARGIN ASSESSMENT." Thesis, 2019.

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Advancements in cancer treatments have increased rapidly in recent years, but cures remain elusive. Surgical tumor resection is a central treatment for many solid malignancies. Residual tumor at surgical margins leads to tumor recurrence. Novel tools for assessing residual tumor at surgical margins could improve surgical outcomes by helping to maximize the extent of resection. Ambient ionization-mass spectrometry (MS) methods generate and analyze ions from minimally prepared samples in near-real-time (e.g. seconds to minutes). These methods leverage the high sensitivity and specificity of mass spectrometry for analyzing gas phase ions and generating those ions quickly and with minimal sample preparation. Recent work has shown that differential profiles of ions, corresponding to phospholipids and small metabolites, are detected from cancerous and their respective normal tissue with ambient ionization-MS methods. When properly implemented, ambient ionization-MS could be used to assess for tumor at surgical margins and provide a molecular diagnosis during surgery.

The research herein reports efforts in developing rapid intraoperative ambient ionization-MS methods for the molecular assessment of cancerous tissues. Touch spray (TS) ionization and desorption electrospray ionization (DESI) were utilized to analyze kidney cancer and brain cancer.

As a demonstration of the applicability of TS-MS to provide diagnostic information from fresh surgical tissues, TS-MS was used to rapidly analyze renal cell carcinoma and healthy renal tissue biopsies obtained from human subjects undergoing nephrectomy surgery. Differential phospholipid profiles were identified using principal component analysis (PCA), and the significant ions were characterized using multiple stages of mass spectrometry and high resolution/exact mass MS. The same TS-MS analyzed renal tissues were subsequently analyzed with DESI-MS imaging to corroborate the TS-MS results, and the significant DESI-MS ions were also characterized with MS.

Significant efforts were made in developing and evaluating a standalone intraoperative DESI-MS system for analyzing brain tissue biopsies during brain tumor surgery. The intraoperative DESI-MS system consists of a linear trap quadrupole mass spectrometer placed on a custom-machined cart that contains all hardware for operating the mass spectrometer. This instrument was operated in the neurosurgical suites at Indiana University School of Medicine to rapidly analyze brain tissue biopsies obtained from glioma resection surgeries. A DESI-MS library of normal brain tissue and glioma was used to statistically classify the brain tissue biopsies collected in the operating room. Multivariate statistical methodologies were employed to predict the disease state and tumor cell percentage of the samples. A DESI-MS assay for detecting 2-hydroxyglutarate (2HG), the oncometabolic product of the isocitrate dehydrogenase (IDH) mutation (a key glioma prognostic marker), was developed and applied to determine the IDH mutation status during the surgical resection. The strengths, weaknesses, and areas of future work in this field are discussed.

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Books on the topic "Intraoperative cancer diagnostics"

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Diagnostic Pathology: Intraoperative Consultation. Elsevier - Health Sciences Division, 2018.

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Harrison, Beth T., and Susan C. Lester. Diagnostic Pathology: Intraoperative Consultation. Elsevier, 2023.

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Book chapters on the topic "Intraoperative cancer diagnostics"

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Ignatov, Valentin, Nikola Kolev, Anton Tonev, Shteryu Shterev, Elitsa Encheva, Tanya Kirilova, Tsvetelina Teneva, and Krassimir Ivanov. "Diagnostic Modalities in Colorectal Cancer –Endoscopy, Ct and Pet Scanning, Magnetic Resonance Imaging (Mri), Endoluminal Ultrasound and Intraoperative Ultrasound." In Colorectal Cancer - Surgery, Diagnostics and Treatment. InTech, 2014. http://dx.doi.org/10.5772/57508.

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Gerstman, Michelle, Orla J. Lacey, and Cyrus Kerawala. "Malignancy." In Oxford Textbook of Anaesthesia for Oral and Maxillofacial Surgery, Second Edition, 167—C15.P163. 2nd ed. Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/med/9780198790723.003.0015.

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Abstract Anaesthesia for oromaxillofacial malignancy surgery can range from minor diagnostic tissue biopsies to major cancer resection, neck dissection, and flap reconstructive procedures. However, the principles and approach remain the same—thorough airway evaluation (including radiological assessment and nasendoscopy), a planned and agreed airway management strategy, preparation for failure, and prioritization of patient oxygenation at all times. This chapter describes oromaxillofacial cancer epidemiology, the range of indications for cancer surgery, the essentials of airway assessment, the range of advanced airway management and oxygenation techniques, the fundamentals of intraoperative care, advanced tracheal extubation strategies, and procedure-specific guidance, including the principles of free flap reconstruction.
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Wilson, Justin W. "Bronchoscopy and Mediastinoscopy Procedures." In Thoracic Anesthesia Procedures, 109–18. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197506127.003.0010.

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Thoracic and diagnostic procedures such as bronchoscopy and mediastinoscopy are fairly common especially for patients with thoracic cancer. The typical surgical progression for thoracic cancer patients is performance of bronchoscopy to demonstrate airway anatomy and check tumor burden throughout the airway and then proceed with mediastinoscopy to sample mediastinal lymph nodes and send to pathology, if the nodes are negative for cancer then subsequent tumor resection is warranted. Standard preoperative workup includes the usual preoperative labs (hematology and chemistry), electrocardiogram, chest X-ray, and computed tomography scan to determine location of tumor especially to adjoining structures. The authors will discuss bronchoscopy and mediastinoscopy in detail and the difficulties and challenges these patients can present from the anesthetic perspective, including preoperative and intraoperative management.
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Conference papers on the topic "Intraoperative cancer diagnostics"

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Hanson, Willard, Najma Abdollahzadeh, Yaling Liu, and Bumsoo Han. "Tissue-Light Interaction During Monitoring of Thermal Lesion Using Quantum Dot Mediated Fluorescence Thermometry." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-205517.

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As cancer diagnostics advance, tumors are increasingly detected at very early stages so that the tumors can be destroyed in situ by localized heating. This can be achieved minimally invasively or completely non-invasively using various energy sources including laser, RF wave, microwave and ultrasound. Despite many advantages of these thermal therapies, the major huddle to the widespread dissemination of thermal therapy is the lack of a reliable intraoperative monitoring technique of the thermal lesion. Currently available monitoring techniques cannot provide reliable real-time information of thermal lesion due to their limited accuracy or accessibility.
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Plancha, M., A. Miguel, D. Djokovic, PA Duarte, C. Barros, and P. Pinto. "1070 Diagnostic accuracy of intraoperative histopathological assessment in endometrial cancer." In ESGO 2021 Congress. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/ijgc-2021-esgo.227.

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Weyers, Brent W., Mark A. Marsden, Julien Bec, Takanori Fukazawa, Roberto P. Frusciante, Athena K. Tam, Dorina Gui, et al. "Intraoperative FLIm for pathology detection and surgical guidance in oral and oropharyngeal cancer patients." In Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX, edited by Caroline Boudoux and James W. Tunnell. SPIE, 2021. http://dx.doi.org/10.1117/12.2576804.

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Nguyen, FT, AM Zysk, EJ Chaney, JG Kotynek, UJ Oliphant, FJ Bellafiore, KM Rowland, PA Johnson, and SA Boppart. "Optical coherence tomography (OCT) as a diagnostic tool for the real-time intraoperative assessment of breast cancer surgical margins." In CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-802.

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Marsden, Mark A., Brent W. Weyers, Takanori Fukazawa, Tianchen Sun, Julien Bec, Regina F. Gandour-Edwards, Dorina Gui, et al. "Intraoperative margin assessment in head and neck cancer using label-free fluorescence lifetime imaging, machine learning and visualization." In Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX, edited by Caroline Boudoux and James W. Tunnell. SPIE, 2021. http://dx.doi.org/10.1117/12.2577051.

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Choolani, Mahesh, Loganath Annamalai, Lin Liu, Khalil Razvi, Changqing Zhao, Gregory Rice, Aniza P. Mahyuddin, Arijit Biswas, Jerry Chan, and Narasimhan Kothandaraman. "Abstract POSTER-CTRL-1211: Haptoglobin identified within ovarian cyst fluid as an accurate intraoperative diagnostic biomarker for epithelial ovarian cancer." In Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.ovcasymp14-poster-ctrl-1211.

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Bats, A., A. Bats, L. Trinquart, L. Trinquart, M. Le Frère-Belda, C. Nos, G. Chatellier, G. Chatellier, F. Lécuru, and F. Lécuru. "Intraoperative Determination of Axillary Node Metastasis: Meta-Analysis of Diagnostic Accuracy Assessment Studies for Frozen Section, Imprint Cytology and Molecular Assays." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-1005.

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Lima, Juliana Ferreira de, Bruna Anderson, Antônio Carlos Toshihiro Nisida, Fabiano Cataldi Engel, and Luiz Henrique Gebrim. "THORACIC DUCT INJURY AFTER MASTECTOMY - CASE REPORT AND LITERATURE REVIEW." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1073.

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Introduction: In adults, the thoracic duct carries about four liters of lymph per day, and its injury can lead to rapid accumulation in the pleural cavity, causing acute and chronic changes in lung dynamics. Thoracic duct injuries are uncommon and occur during surgical procedures in the thoracic region and trauma, such as esophagectomy, mediastinal and pleuro-pulmonary surgical procedures. Surgical injuries have been described after almost all types of thoracic surgical procedures, especially those performed in the upper left thoracic strait. The clinical diagnosis is based most often on the high output of the introduced chest drain, accompanied by a milky aspect. In addition, computed tomography, lymphoscintigraphy and lymphanangiography are possible methods for diagnosis. Clinical series on duct injuries after thoracic surgery report that in approximately 25% to 50% of cases spontaneous closure of the fistula occurs with conservative measures, after the introduction of parenteral nutrition or enteral diet with medium chain triglycerides. The other cases needed clinical and surgical treatment. Operative treatment consists of performing videothoracoscopy or right thoracotomy with identification of the lymphatic duct, followed by ligation. Case report: A 48-year-old woman, born in Santana do Parnaíba, state of São Paulo, with a diagnosis of breast cancer on the left, histological type of invasive breast carcinoma Luminal B, who underwent a modified radical mastectomy (Madden technique) on the left with immediate breast reconstruction. In the intraoperative period, important involvement of the left axillary lymph nodes was evidenced, which may have distorted lymphatic vessels and ducts. It evolved in the late postoperative period with high milky drainage in a suction drain in the left axillary region. Then, a hypothesis of thoracic duct injury was raised as a post-surgical complication. Biochemical analysis of milky secretion showed a high concentration of triglycerides and cytology describes the presence of proteinaceous material and macrophages. A conservative approach was adopted with adjustment of a hyperproteic, hypoglycidic and rich in medium chain triglyceride parenteral diet. The patient underwent lymphoscintigraphy, twenty days after the diagnostic hypothesis, but the fistula was not detected. Progressed with a decrease in the flow gradually until the drain was removed and she was discharged from the hospital in good condition. At the moment, the patient is undergoing adjuvant treatment for breast cancer.
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