Dissertations / Theses on the topic 'Intraocular pressure'
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Rai, Gurjeet Kaur. "Accommodation and intraocular pressure." Thesis, Aston University, 2007. http://publications.aston.ac.uk/14645/.
Full textJohansson, Gabriella. "Effect of phacoemulsification on intraocular pressure." Thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-12619.
Full textMorgan, Andrew J. "Analysis of the intraocular pressure pulse." Thesis, Aston University, 2003. http://publications.aston.ac.uk/14542/.
Full textHallberg, Per. "Applanation Resonance Tonometry for Intraocular Pressure Measurement." Doctoral thesis, Umeå : Tillämpad fysik och elektronik, Umeå univ, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-784.
Full textChang, Jason (Yin-Hao). "Mechano-regulation of intraocular pressure through eNOS." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58342.
Full textGerzenstein, Sabrina Melisa. "Pharmacogenomics of the Intraocular Pressure Response to Glucocorticoids." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_theses/285.
Full textJóhannesson, Gauti. "Intraocular pressure : clinical aspects and new measurement methods." Doctoral thesis, Umeå universitet, Oftalmiatrik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40383.
Full textBello, Simon Antonio. "Intraocular Pressure Sensing and Control for Glaucoma Research." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6466.
Full textPolyzoev, Vasco. "HAND-HELD TONOMETER FOR TRANSPALPEBRAL INTRAOCULAR PRESSURE MEASUREMENT." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/202517.
Full textLjubimova, Darja. "Biomechanics of the Human Eye and Intraocular Pressure Measurements." Doctoral thesis, KTH, Strukturmekanik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11420.
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Agar, Ashish Medical Sciences Faculty of Medicine UNSW. "Pressure effects on neurons: investigations into the pathogenesis of glaucoma." Awarded by:University of New South Wales. School of Medical Sciences, 2006. http://handle.unsw.edu.au/1959.4/31548.
Full textLai, Wing-ki, and 黎穎琪. "Off anti-glaucoma medication study: changes in visual field, retinal nerve fiber layer thickness and riskestimation of glaucoma onset in 1 year follow up." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48333967.
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Medicine
Master
Master of Medical Sciences
Nilsson, Emelie. "Changes in the intraocular pressure value, when wearing orthokeratology lenses." Thesis, University of Kalmar, School of Pure and Applied Natural Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2280.
Full textIntroduction: Quite new on the Swedish market are orthokeratology lenses, used for both correction and myopia control. At the moment there are 22 practitioners in Sweden fitting orthokeratology lenses and 5 of those stands for 75 % of all fittings. Measuring the intraocular pressure in the eye is an important part of an eye- examination, because high intraocular pressure can result in glaucomatous changes. When using the orthokeratology lenses the corneal thickness changes, it decreases in the central epithelium and increases in the midperipheral stroma. The corneal thickness is affecting the intraocular pressure value.
Aim: The aim of the study was to evaluate how the intraocular pressure, measured with a non-contact tonometer, changes when using orthokeratology lenses.
Method: 7 people were fitted with orthokeratology lenses. The intraocular pressure was measured before using the lenses, after the first night, after the third night and after the seventh night. 12 eyes were measured after the tenth night, because of drop- out of two eyes.
Result: Already after the first night a significant decrease in the intraocular pressure occurred with 1, 34 mm Hg (p= 0,049). Day ten the intraocular pressure had an average decrease of 2, 67 ± 2, 14 mm Hg, which was a significant change (p= 0, 002 ).
Discussion: This study shows when wearing orthokeratology lenses a decrease in 2, 67 ± 2, 14 mm Hg at day 10 can be expected.
Chiu, Flora T. (Flora Tze Kwan). "An exploration of through-the-eye intraocular pressure measurement device." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/42118.
Full textIncludes bibliographical references (leaves 70-71).
Glaucoma, caused by an elevated intraocular pressure (IOP), is one of the leading causes of blindness. As constant monitoring of IOP is essential in the treatment of glaucoma, the IOP measurement techniques described in patents and patent applications since 1950 are examined. None of the methods provides a simple and comfortable approach for patients to self monitor their IOPs at different times throughout the day. A through-the-eyelid tonometry method is proposed to address the deficiencies of the previous techniques. Two through-the-eyelid tonometers are designed, and parts of the prototypes are built.
by Flora T. Chiu.
M.Eng.
Nunes, Mariana Pinto. "Effects of methadone on intraocular pressure in dogs and cats." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2018. http://hdl.handle.net/10400.5/16470.
Full textObjective: The purpose of this study was to determine the effects of methadone as a solo-agent of anaesthetic premedication, on intraocular pressure (IOP) in dogs and cats undergoing both elective surgeries or diagnostic procedures. Methods: The study group was composed of 32 and 5 cats. The baseline IOP (T0) of the subjects were registered before IV methadone at the 0.2 mg kg-1 dosage. IOP variations were registered ten (T10) and twenty (T20) minutes after the drug administration. IOP values were measured with rebound tonometry (Icare ®, Helsinki, Finland), each animal being positioned in sternal recumbency, without e-collars and with the head maintained relaxed at the level of the thorax. All variables were compared at each specific time point using a repeated-measures analysis of variance (ANOVA) with R® 3.3.3 software and the R-Commander extension. The differences were considered significant when p < 0.05. Results: The study group was composed of 32 dogs with a mean age of 8,6 ± 3,3 years and 5 cats with a mean age of 6,02 ± 5,3 years. Ophthalmic exam was normal. The mean ± SD baseline (T0) and post-treatment (T10, T20) IOP values were respectively: 17,1 ± 3,32 mm Hg, 16,9 ± 3,37 mm Hg and 16,3 ± 3,33 mm Hg. In the majority of the individuals, IOP levels decreased less significantly at T10 comparing to the mean values at T20. There were no statistically significant differences between baseline values and post-treatment values (p=0.296). Conclusions: There were no statistically significant variations in IOP values in dogs and cats after the administration of methadone as a solo-agent of anaesthetic premedication. Methadone may be a good alternative as anaesthetic premedication in intraocular surgery or in sedation of glaucoma patients since it apparently does not interfere with IOP.
RESUMO - Objetivo: Este estudo teve como objetivo determinar os efeitos do uso de metadona como fármaco único de pré-medicação cirúrgica, na pressão intraocular, tanto em cães, como em gatos, submetidos a procedimentos cirúrgicos eletivos e/ou exames de diagnóstico complementares que necessitassem de sedação prévia. Métodos: O grupo em estudo incluiu cães e gatos submetidos a sedação. Os valores de pressão intraocular foram medidos antes da administração intravenosa de metadona, na dose de 0,2 mg kg-1, e após 10 minutos (T10) e 20 minutos (T20) da mesma. As medições foram efetuadas por tonometria de ressalto (Icare ®, Helsínquia, Finlândia) com o animal posicionado em decúbito ventral, sem uso de colar isabelino e com a cabeça mantida numa posição relaxada ao nível do tórax. Os valores da variável pressão intraocular, obtidos nos três tempos, foram comparados utilizando o teste de análise de variância (ANOVA) para medidas repetidas, com o auxílio do software R® 3.3.3 software e na sua extensão R-Commander. As diferenças foram consideradas significativas quando p< 0.05. Resultados: O grupo em estudo foi composto por 32 cães e 5 gatos com uma média de idades de 8,6 ± 3,3 e 6,02 ± 5,3 anos de idade, respetivamente. Os valores da média ± desvio padrão da pressão intraocular basais (T0) e após a administração de metadona (T10 e T20) foram, respetivamente: 17,1 ± 3,32 mm Hg, 16,9 ± 3,37 mm Hg e 16,3 ± 3,33 mm Hg. Na maioria dos indivíduos, os níveis de pressão intraocular diminuíram de forma menos marcada em T10 comparativamente com T20. Não se observou diferença estatisticamente significativa entre os três tempos em estudo (p=0,296). Conclusões: Não se observaram variações estatisticamente significativas na pressão intraocular em cães e gatos após a administração de metadona como fármaco único de pré-medicação. Este fármaco pode ser uma boa opção na cirurgia intraocular ou na sedação de animais com diagnóstico prévio de glaucoma, uma vez que aparentemente não interfere com a pressão intraocular.
N/A
Irby, Alice L. "Social economic status association with intraocular pressure in rural Alabama." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009m/irby.pdf.
Full textEklund, Anders. "Resonator sensor technique for medical use : An intraocular pressure measurement system." Doctoral thesis, Umeå University, Radiation Sciences, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1.
Full textIn the work of this doctoral dissertation a new resonator sensor technique, first presented in 1989, has been further developed and evaluated with focus on technical characteristics and applications within the medical field.
In a first part a catheter-type tactile sensor using the resonator sensor technique was evaluated in a silicone model and applied to human prostate in vitro. The main finding was that different histological compositions of prostate tissue correlated with the frequency shift, .fS, of the resonator sensor and that the common property was the hardness of the tissue. The results indicated that hardness of the prostate tissue, and maybe hardness of human tissue in general, can be expressed according to a cone penetration standard (DIN ISO 2137) and that the hardness can be measured with this tactile sensor system. The tissue hardness application for the resonator sensor technique has to be further developed and evaluated in a larger study. The study also produced results that has led to the basic understanding of the resonator sensor system. One important result was that .fS of the sensor system was related to the contact area between sensor and sample. This indicated that the resonance sensor could be used for contact area measurement.
In a second part, containing three studies, the area-sensing capability from the first study was utilised in the development and evaluation of the applanation resonator sensor (ARS) for measurement of intraocular pressure (IOP). For the purpose of evaluating IOP-tonometers, an in vitro pig-eye model was developed, and it was shown that a saline column connected to the vitreous chamber could be used successfully to induce variations in IOP.
A ARS sensor with a flat contact surface was applied onto the cornea with constant force and .fS was measured. A mathematical model based on the Imbert-Fick law and the assumption that .fS was linearly related to contact area was proposed and verified with a convincing result. IOP measured with the ARS correlated well (r=0.92, n=360) with the IOP elicited by a saline column.
The ARS in a constant-force arrangement was evaluated on healthy human subjects in vivo. The results verified the sensor principle but revealed a nonnegligible source of error in off-centre positioning between the sensor and cornea. The sensor probe was redesigned and evaluated in the in vitro model. The new probe, with a spherical contact surface against the eye reduced the sensitivity to off-centre positioning. It was also shown that a .fS normalisation procedure could reduce the between-eye differences.
The ARS method for IOP measurement was further developed using combined continuous force and area measurement during the dynamic phase when the sensor initially contacts the cornea. A force sensor was included with the resonator sensor in one probe. Evaluation was performed with the in vitro pig-eye model. The hypothesis was that the IOP could be deduced from the differential change of force and area during that phase. The study showed good accuracy and good reproducibility with a correlation of r=0.994 (n=414) between measured pressure in the vitreous chamber and IOP according to the ARS. Measurement time was short, 77 ms after initial contact. Problems with inter-eye differences and low resolution at high pressures were reduced. The ARS method is the first to combine simultaneous, continuous sampling of both parameters included in the applanation principle. Consequently, there is a potential for reducing errors in the clinical IOP tonometry.
Luce, Alexander Vallejo. "Design of Automated Digital Eye Palpation Exam for Intraocular Pressure Measurement." Thesis, The University of Arizona, 2009. http://hdl.handle.net/10150/192537.
Full textChiu, Yee-hang Thomas. "Intraocular pressure, optic nerve fiber layer thickness and visual field in normotensive eyes with narrow drainage angle /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37207994.
Full textChiu, Yee-hang Thomas, and 趙懿行. "Intraocular pressure, optic nerve fiber layer thickness and visual field in normotensive eyes with narrow drainage angle." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45011102.
Full textLaiquzzaman, Mohammad. "Inter-relations between eyeblinking, tear film and corneal health in older people." Thesis, Glasgow Caledonian University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322281.
Full textPillai, Aditi. "Effects of Body Temperature and General Anesthetics on Intraocular Pressure in Rats." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7351.
Full textHamilton, Kirsten School of Optometry & vVsion Science UNSW. "Corneal hydration and the accuracy of Goldmann tonometry." Awarded by:University of New South Wales. School of Optometry and vVsion Science, 2006. http://handle.unsw.edu.au/1959.4/30468.
Full textMcCafferty, Sean, Garrett Lim, William Duncan, Eniko Enikov, and Jim Schwiegerling. "Goldmann Tonometer Prism with an Optimized Error Correcting Applanation Surface." ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016. http://hdl.handle.net/10150/622594.
Full textBorges, Alessandra Gonçalves. "Efeito do cloridrato de dorzolamida a 2%, maleato de timol a 0,5% e associação de ambos na pressão intra-ocular : estudo experimental em cães /." Botucatu : [s.n.], 2004. http://hdl.handle.net/11449/89128.
Full textResumo: Dentre as doenças oculares diagnosticadas no cão, o glaucoma reveste-se de singular importância, como afecção potencial causadora de cegueira. O aumento da pressão intra-ocular (PIO) é o fator de risco primário para o desenvolvimento da neuropatia óptica glaucomatosa canina. A dorzolamida e o timolol, fármacos utilizados para o tratamento do glaucoma, reduzem a PIO pela diminuição da produção do humor aquoso, embora utilizem diferentes mecanismos de ação. O objetivo do trabalho foi avaliar o efeito do cloridrato de dorzolamida 2%, maleato de timolol 0,5% e da combinação de ambos na pressão intra-ocular de cães normais e verificar possíveis alterações na PIO do olho contra-lateral sem tratamento. Foram utilizados 60 cães, distribuídos em três grupos (G) aleatórios de 20 animais. Cada grupo recebeu tratamento tópico no olho esquerdo com timolol 0,5% (GT), dorzolamida 2% (GD) ou a combinação, timolol 0,5% e dorzolamida 2% (GTD). Em todos os grupos, a mensuração da PIO foi realizada utilizando-se tonômetro de aplanação (Tonopen). As medidas foram realizadas, em ambos os olhos, uma hora antes e uma, duas, quatro, seis e oito horas após a instilação de uma gota do colírio no olho esquerdo. No olho tratado percentual de redução máxima da associação timolol/dorzolamida foi numericamente superior (27%) comparado ao timolol (21,9%) e dorzolamida (22,4%) quando utilizados como monoterapia. O olho não tratado apresentou uma redução significativa da PIO, sendo que a redução máxima para o GT foi de 7%, para o GD de 13,8% e para o GTD de 13,6%. A dorzolamida e a associação timolol/dorzolamida promoveram uma ação redutora maior, após uma e seis horas da sua instilação no olho tratado. A administração tópica do timolol 0,5%, dorzolamida a 2% como monoterapia e a associação fixa destes fármacos resultou na redução significativa da PIO de cães clinicamente normais.
Abstract: Glaucoma is one of the most important ocular diseases in the dog. Increased intraocular pressure (IOP) is the major risk factor for the development of glaucoma. Dorzolamide and timolol are drugs used for the treatment of glaucoma. Both drugs modify aqueous humor outflow by different mechanisms, resulting in decreased IOP. The aim of this work was to evaluate the efficacy of dorzolamide hydrochloride, timolol maleate and the combination of both drugs on IOP of healthy dogs. Sixty adult dogs were randomly and equally assigned to three groups (n = 20 per group). Each group received topical treatment in the left eye with 0,5% timolol, 2% dorzolamide or the combination (0,5% timolol / 2% dorzolamide). IOP measurements were made using aplanation tonometry (Tono-pen) after local instillation of 0,5% proparacaine in he both eyes. Measurements were performed 1 hour before (baseline) instillation of a single drop of the test drugs in the left eye, and at 1, 2, 4, 6 and 8 hours after treatment. Similar measurements were also performed in the right eye (nontreated eye). In the nontreated eye, IOP decreased over time, with a maximum decrease from baseline of 7%, 13,8% and 13,6% in the timolol, dorzolamide e timolol/dorzolamide groups, respectively. In the treated eye, there was a greater reduction in IOP for the combination (27% maximum decrease from baseline) when compared with timolol (21,9%) and dorzolamide (22,4%) groups. Dorzolamide and timolol/dorzolamide caused greater decreases in IOP at 1 and 6 hours after drug instillation. It was concluded that 0,5% timolol, 2% dorzolamide and the combination of these drugs are effective in reducing IOP in healthy dogs.
Mestre
Hedman, Katarina. "Pooling Data from Similar Randomized Clinical Trials Comparing Latanoprost with Timolol; Medical Results and Statistical Aspects." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3392.
Full textPereira, Fabiana Quartiero. "Comparação entre o tonômetro de rebote (Tonovet) e o novo tonômetro de aplanação (Tono-pen a via) durante curva diurna da pressão intraocular de coelhos adultos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/27277.
Full textThe determination of intraocular pressure (IOP) is crucial in eye examination. Currently, new tonometers based on different principles are being continuously developed. The objective was to establish reference values of IOP of adults rabbits without the effect of tranquilizers, utilizing the rebound tonometer (Tonovet ) and the applanation tonometer (Tono-Pen Avia) for measurements. It also aimed to advocate the measurement of IOP throughout the day in this species and compare the results obtained with the two tonometers. The IOP was measured throughout the day (6h, 9h, 12h, 15h and 18h) in 38 New Zealand White rabbits (76 eyes), adults, males or females, with mean weight of 3.5kg and an average age of six months. Previously, the Schirmer tear test, fluorescein test, biomicroscopy with slit lamp and direct ophthalmoscopy were performed in all animals. First, the rebound tonometry was performed and after a minimum of 10 minutes anesthetic drops were instilled and applanation tonometry was carried out. IOP obtained using the two techniques was compared by statistical analysis. The average IOP was 9.51 ± 2.62 mmHg (range 3 - 23 mmHg) and 15.44 ± 2.16 mmHg (range 8 – 26mmHg), with Tonovet and Tono-Pen Avia, respectively. Statistic significant difference between the two tonometers was (P <0.001). The linear regression equation that describes the relationship between the two tonometers was: y = 0.4923 x + 10.754 (y= Tonovet e x= Tono-Pen Avia). Earlier in the day, higher IOPs were recorded, but the average behavior of IOP throughout the day with both devices was statistically the same (p = 0.086). The value of the correlation coefficient was r2 = 0.357. The results show that the Tono-Pen Avia is more variable and overestimates the IOP of rabbits when compared with the Tonovet. In the early hours, the IOP of rabbits was higher than at other times, regardless of the tonometer used.
Claros, Chacaltana Flor Diana Yokoay. "Avaliação da pressão intraocular em chinchilas (chinchilla Lanigera) de diferentes faixas etárias utilizando tonometria de rebote." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/76540.
Full textThe assessment of intraocular pressure (IOP) is essential for the ocular examination. The purpose of this study was to establish reference values of intraocular pressure chinchillas (Chinchilla lanigera) of different age groups. Thirty-six Chinchillas were divided in three groups of 12 animals each, considering the ages designated by GI (animals aged two to six months), GII (aged between 20 and 34 months) and GIII (animals aged between 37 and 135 months). Intraocular pressure was measured at 7, 12 and 19 hours. Tear production was measured, fluorescein test, slit-lamp biomicroscopy and indirect ophthalmoscopy in all animals and IOP was measured using the rebound tonometer (Tono Vet®) set on the P (undefined species) setting, with measurements obtained from each eye. No abnormalities were found on ophthalmic examination. The mean (±SD) of IOP was 2.49 ± 0.56 mmHg, with a range of 2-4 mmHg. The mean (±SD) of IOP for group I, II and III were 2.47 ± 0.581 mmHg, 2.47 ± 0.581 mmHg and 2,51 ± 0.531 mmHg, respectively. No significant differences were found between age and IOP and no significant differences were found between the hours of day and IOP. No significant differences were found between the genders. The IOP in chinchillas is unchanged between genders and age of the animals. The circadian rhythm is not influenced by IOP in chinchillas.
Liu, M. "Characterization of dendritic changes induced by elevated intraocular pressure in a chronic glaucoma model." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1306761/.
Full textHarju, Mika. "Exfoliation glaucoma : studies on intraocular pressure, optic nerve head morphometry, and ocular blood flow." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/harju/.
Full textRenzo, Roberta [UNESP]. "Pressão intra-ocular, condições endoteliais e prostaglandina E2 no humor aquoso de cães com catarata senil madura ou hipermatura." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/88973.
Full textConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Estudaram-se a pressão intraocular, a densidade e a hexagonalidade de células endoteliais, níveis de Prostaglandina E2 e sua correlação com catarata senil madura (n=8) ou hipermatura (n=8). Adicionalmente, foram utilizados valores de Prostaglandina E2 do humor aquoso de cães oftalmologicamente saudáveis (n=7). Para avaliação da pressão intraocular empregou-se tonometria digital de aplanação. A avaliação da densidade e da hexagonalidade das células endoteliais foi realizada por meio de microscopia especular de não contato. Sob anestesia geral, 0,2mL de humor aquoso foram colhidos por meio de paracentese da câmara anterior. As amostras de aquoso foram congeladas e armazenadas à -80 oC para mensuração da concentração de PGE2, por imunoensaio enzimático competitivo. Os valores foram comparados estatisticamente, empregando-se análise de variância de via única, e o teste de múltiplas comparações de Bonferroni. Teste t não pareado foi utilizado para se avaliar os dados obtidos por microscopia especular. Possíveis correlações entre os resultados foram comparadas aplicando-se o teste de Person. Adotou-se nível de significância de p<0,05. Em ambos os grupos observou-se diminuição significativa da pressão intraocular (PIO), entretanto não houve diferença entre eles (p = 0,90). As médias dos valores de densidade celular (CD) e de hexagonalidade (HEX) foram 2253,363 cell/mm² e 59,03% para GSM e 2058,325 cell/mm² e 63,75% para GSH, respectivamente. Entretanto não houve diferença significativa entre ambos, tanto para CD (p=0,201), quanto para HEX (p=0,61). Observou-se incremento nos valores de PGE2 nos grupos com catarata em relação aos cães oftalmologicamente saudáveis (p<0,001), entretanto, não houve diferença significativa entre os grupos com catarata...
Intraocular pressure, endothelial cell density and hexagonality, and aqueous humor prostaglandin E2 (PGE2) were studied and correlated in dogs with mature (n=8) and hypermature (n=8) senil cataratcs. In addition, aqueous humor PGE2 values of ophthalmic healthy dogs (n=7) were used. Non contact specular microscopy was used to evaluate density and hexagonality of endothelial cells. 0.2mL of aqueous humor was collected by means of anterior chamber paracentesis. Aqueous humor samples were frozen at -80 oC and concentration of PGE2 were quantified by means of competitive enzyme immunoassay. PGE2 values were statistically compared with one way analysis of variance and Bonferroni´s multi comparison test. Specular microscopy data were assessed by means of unparied T test. Person´s test was used in order to assess possible correlations among data. Significance was set at value of P < 0.05. Values of endothelial cell density and hexagonality did not change significantly between groups (P = 0.61). PGE2 values were significantly higher in dogs with cataract, when compared with ophthalmic healthy dogs (P < 0.001), however, this parameter did not change significantly between mature and hypermature groups (P > 0.05). Is it possible tosay that cataract patients in stages of maturity or hipermaturity develop uveitis... (Complete abstract click electronic access below)
Borges, Alessandra Gonçalves [UNESP]. "Efeito do cloridrato de dorzolamida a 2%, maleato de timol a 0,5% e associação de ambos na pressão intra-ocular: estudo experimental em cães." Universidade Estadual Paulista (UNESP), 2004. http://hdl.handle.net/11449/89128.
Full textDentre as doenças oculares diagnosticadas no cão, o glaucoma reveste-se de singular importância, como afecção potencial causadora de cegueira. O aumento da pressão intra-ocular (PIO) é o fator de risco primário para o desenvolvimento da neuropatia óptica glaucomatosa canina. A dorzolamida e o timolol, fármacos utilizados para o tratamento do glaucoma, reduzem a PIO pela diminuição da produção do humor aquoso, embora utilizem diferentes mecanismos de ação. O objetivo do trabalho foi avaliar o efeito do cloridrato de dorzolamida 2%, maleato de timolol 0,5% e da combinação de ambos na pressão intra-ocular de cães normais e verificar possíveis alterações na PIO do olho contra-lateral sem tratamento. Foram utilizados 60 cães, distribuídos em três grupos (G) aleatórios de 20 animais. Cada grupo recebeu tratamento tópico no olho esquerdo com timolol 0,5% (GT), dorzolamida 2% (GD) ou a combinação, timolol 0,5% e dorzolamida 2% (GTD). Em todos os grupos, a mensuração da PIO foi realizada utilizando-se tonômetro de aplanação (Tonopen). As medidas foram realizadas, em ambos os olhos, uma hora antes e uma, duas, quatro, seis e oito horas após a instilação de uma gota do colírio no olho esquerdo. No olho tratado percentual de redução máxima da associação timolol/dorzolamida foi numericamente superior (27%) comparado ao timolol (21,9%) e dorzolamida (22,4%) quando utilizados como monoterapia. O olho não tratado apresentou uma redução significativa da PIO, sendo que a redução máxima para o GT foi de 7%, para o GD de 13,8% e para o GTD de 13,6%. A dorzolamida e a associação timolol/dorzolamida promoveram uma ação redutora maior, após uma e seis horas da sua instilação no olho tratado. A administração tópica do timolol 0,5%, dorzolamida a 2% como monoterapia e a associação fixa destes fármacos resultou na redução significativa da PIO de cães clinicamente normais.
Glaucoma is one of the most important ocular diseases in the dog. Increased intraocular pressure (IOP) is the major risk factor for the development of glaucoma. Dorzolamide and timolol are drugs used for the treatment of glaucoma. Both drugs modify aqueous humor outflow by different mechanisms, resulting in decreased IOP. The aim of this work was to evaluate the efficacy of dorzolamide hydrochloride, timolol maleate and the combination of both drugs on IOP of healthy dogs. Sixty adult dogs were randomly and equally assigned to three groups (n = 20 per group). Each group received topical treatment in the left eye with 0,5% timolol, 2% dorzolamide or the combination (0,5% timolol / 2% dorzolamide). IOP measurements were made using aplanation tonometry (Tono-pen) after local instillation of 0,5% proparacaine in he both eyes. Measurements were performed 1 hour before (baseline) instillation of a single drop of the test drugs in the left eye, and at 1, 2, 4, 6 and 8 hours after treatment. Similar measurements were also performed in the right eye (nontreated eye). In the nontreated eye, IOP decreased over time, with a maximum decrease from baseline of 7%, 13,8% and 13,6% in the timolol, dorzolamide e timolol/dorzolamide groups, respectively. In the treated eye, there was a greater reduction in IOP for the combination (27% maximum decrease from baseline) when compared with timolol (21,9%) and dorzolamide (22,4%) groups. Dorzolamide and timolol/dorzolamide caused greater decreases in IOP at 1 and 6 hours after drug instillation. It was concluded that 0,5% timolol, 2% dorzolamide and the combination of these drugs are effective in reducing IOP in healthy dogs.
Kusne, Yael, Paul Kang, and Robert Fintelmann. "A retrospective analysis of intraocular pressure changes after cataract surgery with the use of prednisolone acetate 1% versus difluprednate 0.05%." DOVE MEDICAL PRESS LTD, 2016. http://hdl.handle.net/10150/622602.
Full textÅström, Siv. "Long-term follow-up of pseudoexfoliation, intraocular pressure and glaucoma : epidemiological studies in northern Sweden." Doctoral thesis, Umeå universitet, Oftalmiatrik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-64301.
Full textMcCafferty, Sean, Jason Levine, Jim Schwiegerling, and Eniko T. Enikov. "Goldmann applanation tonometry error relative to true intracameral intraocular pressure in vitro and in vivo." BIOMED CENTRAL LTD, 2017. http://hdl.handle.net/10150/626266.
Full textRobinson, Christa Lee. "Evaluation of efficacy and biocompatibility of indirect intraocular pressure monitoring using a telemetric scleral sensor." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1274142444.
Full textKim, Bongsu. "Multidisciplinary Engineered Approaches to Investigate Human Trabecular Meshwork Endothelial Cells in Regulation of Intraocular Pressure." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1307640155.
Full textKotikoski, Hanna. "Effects of nitric oxide donors and cyclic GMP on intraocular pressure and aqueous humor dynamics." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/biola/vk/kotikoski/.
Full textVitish-Sharma, Parveen. "The effect of Trendelenburg positioning in laparoscopic colorectal surgery on intraocular pressure and cognitive function." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/48966/.
Full textFriström, Björn. "Aspects of the diagnosis and treatment of glaucoma /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med690s.pdf.
Full textChou, Tsung-Han. "Age-Related Structural and Functional Changes of the Mouse Eye: Role of Intraocular Pressure and Genotype." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/532.
Full textTran, Sung. "Development of a Sensor Readout Integrated Circuit Towards a Contact Lens for Wireless Intraocular Pressure Monitoring." DigitalCommons@CalPoly, 2017. https://digitalcommons.calpoly.edu/theses/1750.
Full textSawamura, Megumi. "Development of novel treatment against glaucoma; Intraocular pressure-lowering by cytoskeletal drugs and neuroprotection by neurotrophic factors." Kyoto University, 2001. http://hdl.handle.net/2433/150551.
Full textJe, Shindy. "Changes in spatial summation in response to intraocular pressure-lowering treatment in glaucoma : evidence of neural remodeling?" Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/110760/.
Full textKreuz, André Carvalho. "Eletrorretinograma de padrão reverso macular e multifocal e tomografia de coerência óptica em olhos suspeitos de glaucoma e glaucomatosos com perda de hemicampo." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-06022017-110458/.
Full textPurpose: To evaluate the ability of macular and multifocal (mf) pattern electroretinogram (PERG) to differentiate glaucoma suspects (GS) and glaucoma with hemifield loss (GHL) from controls, to compare the discrimination ability of PERG and fourier-domain optical coherence tomography (fdOCT), and to assess the relationship between PERG and fdOCT measurements. Methods: Standard automated perimetry (SAP), steady-state and transient PERG responses and mfPERG measurements were obtained from GS (n=14, 24 eyes), GHL (n=5, 7 eyes) and controls (n=19, 22 eyes). The following fdOCT parameters were investigated: circumpapillary retinal nerve fiber layer (cpRNFL), full-thickness macula, and segmented macular layer thicknesses. Measurements were compared using mixed effects linear models. The relationships between measurements and the diagnostic performance of each technology were also assessed. Results: Compared to controls, average P50 peak time transient PERG responses were reduced in GS and GHL, whereas average phase and amplitude steady-state and mfPERG responses were abnormal only in GHL. The average fdOCT-measured cpRNFL and macular thickness measurements in GS and GHL differed significantly from controls. A significant relationship was found between PERG and most fdOCT or central SAP sensitivity parameters. Principal component regression analysis revealed that optic disc and macular OCT parameters, along with mfPERG and transient PERG parameters had statistically similar ability to discriminate GS from controls. Conclusions: PERG and OCT parameters may be abnormal, with significant correlations between measurements, in a high percentage of GS eyes with normal SAP. Our findings suggest that both technologies may be helpful and complementary in early glaucoma detection
Roubeix, Christophe. "Intérêt des cellules souches mésenchymateuses dans la thérapie du glaucome." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066535/document.
Full textGlaucoma is a sight-threatening retinal neuropathy associated with elevated intraocular pressure (IOP) due to degeneration and fibrosis of the trabecular meshwork (TM). Glaucoma medications aim to reduce IOP without targeting the specific TM pathology, which could explain treatment failure observed in some cases. Bone-marrow mesenchymal stem cells (MSCs) are used today in various clinical studies to treat various degenerative processes. Here, we investigated the potential of MSC therapy in an ocular hypertension model. We demonstrated a rapid and long-lasting in vivo effect of MSC transplantation that significantly reduced IOP in hypertensive eyes induced by episcleral vein cauterization (EVC). MSCs were found located to the ciliary processes and the TM and are able to survive at these places. Enumeration of retinal ganglion cells (RGCs) on whole flat-mounted retina highlighted a protective effect of MSCs on RGC death. In vitro, the effect of MSC-conditioned medium (MSC-CM) on both the primary human trabecular meshwork (hTM) and RGCs showed that MSC-CM promotes: (i) hTM survival by activating the antiapoptotic pathway, Akt, (ii) hTM decontractibility as analyzed by the decrease in myosin phosphorylation and (iii) inhibition of TGF-β2-dependent profibrotic phenotype acquisition in hTM, (iiii) RGC survival and neuritic outgrowth in vitro. Finally, MSCs injection in the ocular anterior chamber in a rat model of ocular hypertension provides a neuroprotective effect in the glaucoma pathophysiology directly on RGC and indirectly via TM protection. These results originally demonstrate that MSCs represent promising tool for treating ocular hypertension and retinal cell degeneration
Beckman, Rehnman Jeannette. "New methods to evaluate the effect of conventional and modified crosslinking treatment for keratoconus." Doctoral thesis, Umeå universitet, Oftalmiatrik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110531.
Full textRenzo, Roberta. "Pressão intra-ocular, condições endoteliais e prostaglandina E2 no humor aquoso de cães com catarata senil madura ou hipermatura /." Jaboticabal, 2012. http://hdl.handle.net/11449/88973.
Full textBanca: Adriana Morales
Banca: Alexandre Lima de Andrade
Resumo: Estudaram-se a pressão intraocular, a densidade e a hexagonalidade de células endoteliais, níveis de Prostaglandina E2 e sua correlação com catarata senil madura (n=8) ou hipermatura (n=8). Adicionalmente, foram utilizados valores de Prostaglandina E2 do humor aquoso de cães oftalmologicamente saudáveis (n=7). Para avaliação da pressão intraocular empregou-se tonometria digital de aplanação. A avaliação da densidade e da hexagonalidade das células endoteliais foi realizada por meio de microscopia especular de não contato. Sob anestesia geral, 0,2mL de humor aquoso foram colhidos por meio de paracentese da câmara anterior. As amostras de aquoso foram congeladas e armazenadas à -80 oC para mensuração da concentração de PGE2, por imunoensaio enzimático competitivo. Os valores foram comparados estatisticamente, empregando-se análise de variância de via única, e o teste de múltiplas comparações de Bonferroni. Teste t não pareado foi utilizado para se avaliar os dados obtidos por microscopia especular. Possíveis correlações entre os resultados foram comparadas aplicando-se o teste de Person. Adotou-se nível de significância de p<0,05. Em ambos os grupos observou-se diminuição significativa da pressão intraocular (PIO), entretanto não houve diferença entre eles (p = 0,90). As médias dos valores de densidade celular (CD) e de hexagonalidade (HEX) foram 2253,363 cell/mm² e 59,03% para GSM e 2058,325 cell/mm² e 63,75% para GSH, respectivamente. Entretanto não houve diferença significativa entre ambos, tanto para CD (p=0,201), quanto para HEX (p=0,61). Observou-se incremento nos valores de PGE2 nos grupos com catarata em relação aos cães oftalmologicamente saudáveis (p<0,001), entretanto, não houve diferença significativa entre os grupos com catarata... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Intraocular pressure, endothelial cell density and hexagonality, and aqueous humor prostaglandin E2 (PGE2) were studied and correlated in dogs with mature (n=8) and hypermature (n=8) senil cataratcs. In addition, aqueous humor PGE2 values of ophthalmic healthy dogs (n=7) were used. Non contact specular microscopy was used to evaluate density and hexagonality of endothelial cells. 0.2mL of aqueous humor was collected by means of anterior chamber paracentesis. Aqueous humor samples were frozen at -80 oC and concentration of PGE2 were quantified by means of competitive enzyme immunoassay. PGE2 values were statistically compared with one way analysis of variance and Bonferroni's multi comparison test. Specular microscopy data were assessed by means of unparied T test. Person's test was used in order to assess possible correlations among data. Significance was set at value of P < 0.05. Values of endothelial cell density and hexagonality did not change significantly between groups (P = 0.61). PGE2 values were significantly higher in dogs with cataract, when compared with ophthalmic healthy dogs (P < 0.001), however, this parameter did not change significantly between mature and hypermature groups (P > 0.05). Is it possible tosay that cataract patients in stages of maturity or hipermaturity develop uveitis... (Complete abstract click electronic access below)
Mestre
Verstappen, Annita A. (Annita Apollonia). "Cellular mechanisms of ocular hypotensive effects of a₂-adrenergic agonists." Thesis, University of North Texas, 1993. https://digital.library.unt.edu/ark:/67531/metadc798263/.
Full textTran, Tung Vu. "Ocular Hypotensive Effect of the α2-Adrenergic Agonist, Lofexidine." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc501156/.
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