Academic literature on the topic 'Intra-intestinal'
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Journal articles on the topic "Intra-intestinal"
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Jessurun, Jose. "Intra-Alveolar Intestinal Epithelium." International Journal of Surgical Pathology 23, no. 3 (January 27, 2015): 196–201. http://dx.doi.org/10.1177/1066896915568992.
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Malpas, T. J., N. MacLachlan, E. Dykes, and E. M. Kiely. "Prenatal intestinal perforation and intra-abdominal lymphangioma." Prenatal Diagnosis 27, no. 9 (2007): 882–83. http://dx.doi.org/10.1002/pd.1794.
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Henriques, Alexandre Cruz, Sérgio Pezzolo, Marise Gomes, Carlos Alberto Godinho, Viviane Aparecida Sotto Bazalia, and Manlio Basilio Speranzini. "Preparo intra-operatório do cólon." Revista do Colégio Brasileiro de Cirurgiões 28, no. 4 (August 2001): 271–74. http://dx.doi.org/10.1590/s0100-69912001000400007.
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OBJETIVO: Apresentar nossa experiência com o preparo intra-operatório do cólon no tratamento de pacientes com obstrução neoplásica do cólon esquerdo. MÉTODO: Vinte e três pacientes com obstrução neoplásica do cólon esquerdo foram operados no Hospital de Ensino da Faculdade de Medicina do ABC e no Hospital São Bernardo no período de 1992 a 1999. O preparo intra-operatório do cólon e a anastomose intestinal primária foram realizados em todos os pacientes e os resultados analisados. RESULTADOS: Em todos os pacientes o preparo de cólon foi adequado e a anastomose intestinal primária foi realizada em condições satisfatórias. Um paciente (4,3%) apresentou fístula bloqueada e outro (4,3%) broncopneumonia, complicações estas não relacionadas com o método de preparo intestinal; ambos evoluíram bem com tratamento clínico. Os demais não apresentaram complicações e permaneceram internados em média sete dias. CONCLUSÕES: O preparo intra-operatório do cólon é um método simples, seguro e permite a reconstrução imediata do trânsito intestinal em situações adversas.
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Eswaravaka, Sai Krishna, Swanit Hemant Deshpande, Roshan Chiranjeev, and Jayashri Sanjay Pandya. "Intra-abdominal small intestinal desmoid tumour mimicking GIST." BMJ Case Reports 14, no. 2 (February 2021): e237032. http://dx.doi.org/10.1136/bcr-2020-237032.
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Desmoid tumours, also known as aggressive fibromatosis, are fibromuscular neoplasms that arise from mesenchymal cell lines. Desmoid tumours are usually benign and are locally aggressive tumours. We report a case of a 31-year-old man presenting with abdominal mass associated with dyspepsia and early satiety. CT scan demonstrated a large heterogeneous mass adherent to or arising from the jejunum. The patient underwent a successful elective exploratory laparotomy with resection of the tumour arising from the wall of the ileum with a 10 cm margin. The patient had an uneventful recovery and no recurrence at 6-month follow-up. Pathology report and immunohistochemistry analysis revealed the mass to be a primary desmoid tumour of the small bowel, as the tumour was negative for c-kit and Discovered on GIST 1 (DOG-1) and positive for beta-catenin and smooth muscle actin.
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Wells, C. L. "Intestinal bacteria translocate into experimental intra-abdominal abscesses." Plastic and Reconstructive Surgery 78, no. 6 (December 1986): 843. http://dx.doi.org/10.1097/00006534-198678060-00102.
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Hoffman, James S., David R. Cave, and Desmond Birkett. "Intra-operative enteroscopy with a sonde intestinal fiberscope." Gastrointestinal Endoscopy 40, no. 2 (March 1994): 229–30. http://dx.doi.org/10.1016/s0016-5107(94)70174-1.
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Zhang, Li, Xiaoying Xing, Jia Ding, Xiuyun Zhao, and Gaofu Qi. "Surfactin variants for intra-intestinal delivery of insulin." European Journal of Pharmaceutics and Biopharmaceutics 115 (June 2017): 218–28. http://dx.doi.org/10.1016/j.ejpb.2017.03.005.
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Sakai, Tohru, Takashi Agui, and Kozo Matsumoto. "Intestinal intra-epithelial lymphocytes in LEC mutant rats." Immunology Letters 41, no. 2-3 (July 1994): 185–89. http://dx.doi.org/10.1016/0165-2478(94)90130-9.
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Reuter, Simone, and Srinivasan Krishnamurthy. "Intra-uterine implant (GyneFix) lost via intestinal route?" Journal of Family Planning and Reproductive Health Care 27, no. 3 (July 1, 2001): 159–60. http://dx.doi.org/10.1783/147118901101195380.
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Lau, W. Y., S. Y. Wong, H. Ngan, S. T. Fan, and K. K. Wong. "Intra-operative localization of bleeding small intestinal lesions." British Journal of Surgery 75, no. 3 (March 1988): 249–51. http://dx.doi.org/10.1002/bjs.1800750321.
Full textDissertations / Theses on the topic "Intra-intestinal"
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Arranz, Eduardo. "Intestinal antibodies and intra-epithelial lymphocytes in potential coeliac disease." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/19815.
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This work refers to the immunological abnormalities found in coeliac disease and other patients with similar gastro-intestinal symptoms but a morphologically normal biopsy. I assessed the use of jejunal fluid for studies of intestinal immunity, possible leakage of plasma proteins, and proportion of locally produced sIgA. Previous work with Dr. O'Mahony showed that DH patients without enteropathy, had an abnormal pattern of intestinal antibodies, as found in untreated and treated coeliacs after mucosal healing. This led to the characterization of the CIA pattern, a potential marker of latent coeliac disease. I examined its frequency in a large cohort of patients referred for diagnostic jejunal biopsy. Jejunal fluid immunoglobulins and IgA and IgM antibodies to GLI, OVA, and BLG; and serum IgG and IgA antibodies to GLI, were measured by ELISA. Between 15-20% of the patients were CIA positive, some of them with high IEL counts in jejunum. Studies of epithelial TCR τδ cells in frozen sections showed a correlation between high IEL τδ counts and CIA pattern. Almost 40% of patients have one or more immunological indices of potential coeliac disease, but no other associations were found. I studied the immunopathogenesis of the CIA pattern, by counting plasma cells, measuring cytokine levels in secretions, and cell activation markers in mucosa. Trials of gluten-free diet have shown clinical gluten-sensitivity without enteropathy in some patients. One of them, who was positive for three markers, has developed subtotal villus atrophy after taking extra gluten.
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Wilson, John Edward, University of Western Sydney, Faculty of Environmental Management and Agriculture, and School of Agriculture and Rural Development. "A comparison of alternate mucosal routes of prophylactic immunisation using a mouse model of Helicobacter infection." THESIS_FEMA_ARD_Wilson_J.xml, 2001. http://handle.uws.edu.au:8081/1959.7/511.
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Throughout history a diversity of animal species have been used and studied extensively in the development of vaccines for the benefit of humans and animals alike. As mice are a relatively easy species to maintain, handle and manipulate, and have the advantage of being cost effective, they are commonly employed as animal models in the investigation of immunisation strategies against mucosal associated pathogens. Vaccine research against the human gastric pathogen Helicobacter pylori is extensively conducted in a mouse model and typically uses intra-gastric administration for the testing of potential vaccine candidates. An inherent complication with this route, however, is that the vaccine constituents may be inadequately delivered to sites of specific immunity and consequently may not be the optimal method for vaccine delivery. In the present study a mouse model of H. pylori infection was used to determine the efficacy of alternate mucosal routes of immunisation from examination of protective immunity, immune responses and the practical aspects of vaccine administration. Commencing with the optimisation of intra-intestinal immunisation, the direct injection of a H. pylori vaccine to initiator sites of the mucosal immune system established baseline data of dose rates for the comparative analysis of intra-gastric, intra-nasal and intra-rectal immunisation. Following the development of simple administration techniques whilst maintaining the welfare of the animals, intra-nasal immunisation was shown to elicit the highest level of prophylaxis against H. pylori challenge. Effective prophylaxis was also shown to be dependent upon a specific ratio of the vaccine constituents. When using whole cell lysate of H. pylori and the mucosal adjuvant cholera toxin, the ratio of antigen:adjuvant for optimal protective immunity was 10:1. The outcomes of this study have proved conclusively the necessity for optimisation of all aspects of immunisation in an animal model of infection.Master of Science (Hons)
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Teixeira, Antonio Roberto Franchi 1968. "Influencia da exposição intestinal ao liquido amniotico sobre o crescimento intra-uterino e o crescimento intestinal em um modelo de gastrosquise experimental." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312987.
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Orientador: Lourenço Sbragia NetoTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-04T08:45:30Z (GMT). No. of bitstreams: 1 Teixeira_AntonioRobertoFranchi_D.pdf: 2419547 bytes, checksum: 40528baa15df0a8567524f7763530464 (MD5) Previous issue date: 2004
Resumo: Gastrosquise é um defeito do fechamento da parede abdominal na região para-umbilical geralmente à direita, por onde as alças intestinais são exteriorizadas para a cavidade amniótica. O contato do intestino com o líquido amniótico (LA) leva à inflamação e espessamento das alças, imaturidade dos plexos mioentéricos e ao retardo do trânsito intestinal. A maior repercussão neonatal da imaturidade intestinal na gastrosquise é o longo tempo de hospitalização que pode levar a complicações graves como translocação bacteriana e sepse. Além disso, a maior parte desses neonatos apresenta restrição do crescimento intra-uterino (RCIU) cuja causa não está bem esclarecida. O objetivo deste estudo é avaliar a influência do tempo de exposição do intestino ao LA sobre o crescimento intestinal e sua repercussão no peso corporal em um modelo de gastrosquise em ratos. Dois grupos de fetos de rato Spreague-Dowley (termo =21,5 dias) foram criados: Grupo I - fetos operados aos 18,5 dias de gestação e Grupo II - fetos operados aos 19,5 dias de gestação, ambos constituídos por 20 tríades de gastrosquise (G), controle (C) e sham (S). Os animais foram comparados quanto ao peso corporal (PC), peso intestinal (PI) e comprimento intestinal (CI) e suas relações (PI/PC; PI/CI; PC-PI). Para comparação com fetos de gastrosquise, foram estabelecidas curvas de PC, PI e CI a partir de fetos normais sacrificados em diferentes idades gestacionais (18,5; 19,5; 20,5 e 21,5 dias). Os resultados demonstraram que os fetos com gastrosquise apresentaram PC menor (p<0,005), PI maior (p<0,005), CI menor (p<0,005) e PC-PI menor (p<0,005) de que seus controles. Os fetos do Grupo I apresentaram maior encurtamento em relação ao Grupo II (42% x 33%) (p<0,05). Conclui-se que a maior exposição das alças ao LA causa um maior encurtamento intestinal, e o RCIU é uma conseqüência direta da gastrosquise. Os resultados deste experimento sugerem que a antecipação do trabalho de parto em fetos portadores de gastrosquise e RCIU pode ser benéfica ao evitar um maior encurtamento intestinal
Abstract: Gastroschisis is a defect in the abdominal wall closure affecting the paraumbilical region, mainly in the right side, where small bowel protudes towards amniotic cavity. Bowel contact with amniotic fluid (AF) leads to bowel inflammation and swelling. Imaturity of myoenteric plexus and retardation of intestinal transit. Major neonatal gastroschisis repercussion is delayed hospital ingress time which may lead to severe complication as bacterial translocation and sepsis. Nevertheless the majority of these newborns present intrauterine growth restriction (IUGR) of not yet established cause. The aim of this study is to evaluate the influence of time of bowel exposure to AF on intestinal growth and its repercussion in body weight in a model of gastroschisis in the rat. Two groups of Spreague-Dowley rat fetuses (term=21.5 days) were created. Group I- operated at gestational day 18.5 and Group II- operated at gestational day 19.5, both consisting of 20 triads of gastroschisis (G), control (C) and sham (S). Animals were compared concerning body weight (BW), intestinal weight (IW), and intestinal length (IL) and their relations (IW/BW; IW/IL; BW-IW). For comparison with gastroschisis fetuses
Doutorado
Cirurgia
Doutor em Cirurgia
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Bellegarde, Marie-José. "Trophicite du tractus gastro-intestinal contribution à l'étude de sa régulation neuro-endocrine et des mécanismes intra-cellulaires impliquée dans la prolifération cellulaire /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37602772n.
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Wilson, John Edward. "A comparison of alternate mucosal routes of prophylactic immunisation using a mouse model of Helicobacter infection." Thesis, View thesis, 2001. http://handle.uws.edu.au:8081/1959.7/511.
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Throughout history a diversity of animal species have been used and studied extensively in the development of vaccines for the benefit of humans and animals alike. As mice are a relatively easy species to maintain, handle and manipulate, and have the advantage of being cost effective, they are commonly employed as animal models in the investigation of immunisation strategies against mucosal associated pathogens. Vaccine research against the human gastric pathogen Helicobacter pylori is extensively conducted in a mouse model and typically uses intra-gastric administration for the testing of potential vaccine candidates. An inherent complication with this route, however, is that the vaccine constituents may be inadequately delivered to sites of specific immunity and consequently may not be the optimal method for vaccine delivery. In the present study a mouse model of H. pylori infection was used to determine the efficacy of alternate mucosal routes of immunisation from examination of protective immunity, immune responses and the practical aspects of vaccine administration. Commencing with the optimisation of intra-intestinal immunisation, the direct injection of a H. pylori vaccine to initiator sites of the mucosal immune system established baseline data of dose rates for the comparative analysis of intra-gastric, intra-nasal and intra-rectal immunisation. Following the development of simple administration techniques whilst maintaining the welfare of the animals, intra-nasal immunisation was shown to elicit the highest level of prophylaxis against H. pylori challenge. Effective prophylaxis was also shown to be dependent upon a specific ratio of the vaccine constituents. When using whole cell lysate of H. pylori and the mucosal adjuvant cholera toxin, the ratio of antigen:adjuvant for optimal protective immunity was 10:1. The outcomes of this study have proved conclusively the necessity for optimisation of all aspects of immunisation in an animal model of infection.
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Maillard, Florie. "Influence des modalités d'exercices sur le microbiote intestinal et la masse grasse abdominale : interrelation intestin / tissu adipeux sur des modèles de pathologies inflammatoires." Thesis, Université Clermont Auvergne (2017-2020), 2018. http://www.theses.fr/2018CLFAS007/document.
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L’obésité et la maladie de Crohn (MC) sont deux pathologies inflammatoires chroniques caractérisées par un développement de la masse grasse viscérale et une dysbiose. L’activité physique (AP) impactant positivement ces deux paramètres, elle apparait donc comme une stratégie thérapeutique prometteuse dans la prise en charge de ces patients. Dans ce contexte, l’objectif de ce travail était d’étudier l’effet de l’AP sur l’interaction microbiote-tissu adipeux. Sur un versant clinique, nos résultats ont confirmé l’efficacité de l’entrainement intermittent de haute intensité (HIIT) pour diminuer le tissu adipeux viscéral chez des sujets en surpoids et/ou obèses. Sur un modèle d’obésité génétique (rat Zucker), nos travaux ont montré que l’entraînement de type HIIT diminuait la masse grasse totale et viscérale mais cela indépendamment du microbiote intestinal. L’étude de la voie de la lipolyse a montré un effet anti-lipolytique du HIIT dans le tissu adipeux sous-cutané, pouvant ainsi partiellement expliquer la diminution du tissu adipeux viscéral. En outre, le HIIT améliore, pour une moindre durée de pratique (vs. l’entraînement continu d’intensité modérée), la tolérance au glucose et le statut inflammatoire. Dans un modèle d’inflammation intestinale mimant la MC, nous avons également mis en évidence que l’AP spontanée augmentait l’expression des protéines des jonctions serrées pouvant participer à la réduction de l'endotoxémie métabolique. En parallèle, l’AP spontanée favorise les bactéries bénéfiques pour la santé et augmente les niveaux de butyrate dans les selles. Ces adaptations participent à la réduction du tissu adipeux viscéral mésentérique caractérisant la MC. En conclusion, l’AP, à travers différentes modalités d’exercice, se révèle comme une « thérapie » attractive et innovante dans la prévention et/ou la prise en charge de ceux pathologies inflammatoires chroniquesObesity and Crohn's disease (CD) are two chronic inflammatory diseases characterized by development of visceral fat mass and dysbiosis. Physical activity (PA) has a positive impact on these two parameters. Consequently, PA appears as a promising therapeutic strategy for the management of these patients. In this context, the objective of this work was to study the effect of PA on the microbiota-adipose tissue cross-talk. Our clinical results confirmed the effectiveness of high intensity intermittent training (HIIT) to reduce visceral adipose tissue in overweight and/or obese volunteers. Then, using an animal model of genetic obesity (Zucker rats), we found that HIIT decreases total and visceral fat mass, independently of gut microbiota. Analysis of the lipolysis pathway showed an anti-lipolytic effect of HIIT in the subcutaneous adipose tissue, and this could explain the decrease in visceral adipose tissue. In addition, compared with continuous moderate intensity training, HIIT improved glucose tolerance and the inflammatory status despite the shorter exercise duration. Finally, in an animal model of CD, we found that spontaneous PA increased the expression of tight junction proteins, contributing to the reduction of metabolic endotoxemia. Concomitantly, spontaneous PA promoted healthy bacteria in the colon and increased fecal butyrate levels. These adaptations limited the expansion of mesenteric visceral adipose tissue, a typical CD feature. In conclusion, PA, through different exercise modalities, appears as an attractive and innovative « therapy » for these two chronic inflammatory diseases
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Castanho, Juliana Araujo. "Estudo de variabilidade intra e interobservador e expressão imuno-histoquímica das proteínas dos genes de reparo do DNA nos pólipos serrilhados dos hemicólons direito e esquerdo." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/129702.
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INTRODUÇÃO: Estudos que avaliaram a concordância diagnóstica entre patologistas entre pólipos hiperplásicos (PH) e pólipos sésseis serrilhados (PSS) demonstraram uma grande variabilidade interobservador mesmo entre especialistas em patologia gastrointestinal. O protocolo de acompanhamento dos PSS não é modificado conforme a localização da lesão e isto pode ser determinado por eventuais diferenças na expressão das proteínas MLH1 e MSH2. OBJETIVOS: Identificar diferenças na concordância diagnóstica que podem reforçar a necessidade de estratégias específicas para melhorar a uniformidade dos diagnósticos. Avaliar a expressão imuno-histoquímica das proteínas MLH1 e MSH2 entre lesões dos hemicólons direito e esquerdo. MÉTODOS: Foram revisados 132 exames anatomopatológicos com diagnóstico de pólipo séssil serrilhado ou pólipo hiperplásico por dois patologistas com ênfase em gastroenterologia e um terceiro sem ênfase em gastroenterologia. Foram realizados exames imuno-histoquímicos para avaliação da expressão das proteínas MLH1 e MSH2 em 108 lesões. RESULTADOS: Foram realizadas duas avaliações por um dos patologistas com ênfase em gastroenterologia para determinar a concordância intraobservador. Dos 64 PH, 2 (3,1%) foram reclassificadas como mucosa colônica normal e 4 (6,2%) foram rediagnosticados como PSS. Das 60 lesões inicialmente diagnosticadas como PSS, 1 (1,7%) foi reclassificada como PH. O teste de Kappa para concordância resultou no valor de 0,89. Os 117 pólipos que apresentaram concordância foram revisados pelo segundo patologista com ênfase em gastroenterologia. Dos 58 PH, 1 (1,7 %) foi readiagnosticado como mucosa colônica normal e 4 (6,9%), foram readiagnosticados como PSS. Dos 59 PSS, 4 (6,8%) foram rediagnosticadas como PH pelo segundo patologista. A variabilidade interobservador resultou em um valor de Kappa de 0,85. Os 108 pólipos que apresentaram concordância nas avaliações anteriores foram também analisados por um terceiro patologista sem ênfase em gastroenterologia. Dos 55 PSS, 25 (45,4%) foram diagnosticadas como PH pelo patologista geral. Todos os PH diagnosticados pelo patologista geral foram diagnosticados como pólipo hiperplásico pelos dois primeiros patologistas. O valor do teste Kappa para concordância entre os três patologistas foi de 0,54. O estudo imuno-histoquímico mostrou-se positivo em todas as lesões tanto para expressão da proteína MLH1 quanto para MSH2. CONCLUSÃO: O valor de Kappa encontrado de 0,89 para concordância intraobservador e 0,85 para interobservador entre os patologistas com ênfase em gastroenterologia mostra uma concordância classificada como alta. O valor de Kappa de 0,55 resultante da comparação entre os patologistas com e sem interesse especial em gastroenterologia, mostra uma concordância moderada. É importante considerar que nenhum pólipo hiperplásico diagnosticado pelo patologista geral recebeu o diagnóstico de pólipo séssil serrilhado nas avaliações anteriores. Com isso, podemos observar que a dificuldade diagnóstica está relacionada estritamente aos PSS e isso pode ser explicado pela subjetividade no diagnóstico destas lesões.INTRODUCTION: Studies of interobserver agreement among pathologists for the diagnosis of hyperplastic polyps (HPPs) and sessile serrated polyps (SSPs) have demonstrated substantial interobserver variability, even amidst experts in gastrointestinal pathology. There is no difference in the SSP follow-up protocol according to its location however it may change as a consequence of MLH1 and MSH2 protein expression variation. OBJECTIVES: To identify differences in diagnostic concordance that could justify specific strategies to improve diagnostic uniformity. To study the immunohistochemical analysis for the expression of MLH1 and MSH2 proteins in the right and left hemicolons. METHODS: One hundred twenty-four anatomic pathology specimens with a diagnosis of SSP or HPP were examined by two pathologists with a special interest in gastroenterology (specialists) and one general pathologist. Immunohistochemical analysis for the expression of MLH1 and MSH2 protein was conducted in 108 lesions. RESULTS: Two assessments were conducted by one of the specialist pathologists to determine intraobserver agreement. Of the 64 HPP specimens, 2 of the entire sample (3.1%) were reclassified as normal colonic mucosa and 4 (6.2%) were reassessed as SSPs. Of the 60 lesions initially diagnosed as SSPs, 1 (1.7%) was reclassified as HPPs. The kappa statistic for agreement was 0.89. The 117 specimens in which there were no diagnostic disagreements were then reassessed by the second specialist pathologist. Of 58 HPPs, 1 (1.7%) was reclassified as normal colonic mucosa and 4 (6.9%) were reclassified as SSPs. Of 59 the SSPs, 4 (6.8%) were reclassified as HPPs by the second pathologist. This interobserver variability yielded a kappa value of 0.85. Finally, the 108 specimens in which there were no diagnostic disagreements in the preceding assessments were reviewed by a third pathologist with no special interest in gastroenterology. Of 55 SSPs, 25 (45.4%) were diagnosed as HPPs by the general pathologist. All HPPs diagnosed by the general pathologist had been diagnosed as such by the two specialist pathologists. The kappa value for agreement among the three pathologists was 0.54. The immunohistochemical analysis was positive for both MLH1 and MSH2 protein in all the lesions studied. CONCLUSION: The kappa values of 0.89 for intraobserver agreement and 0.85 for interobserver agreement between the gastrointestinal pathologists are indicative of substantial agreement. The kappa value of 0.55 for comparison among pathologists with and without a special interest in gastroenterology indicates moderate agreement. It is worth noting that no hyperplastic polyps diagnosed by the general pathologist had been diagnosed as sessile serrated adenoma on previous assessments. Therefore, we conclude that diagnostic difficulty is strictly associated with SSPs, which may be explained by the subjective nature of diagnosis of these lesions.
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Addou, Samia. "Conséquences de l'adaptation à un régile hyperprotéique sur la structure de l'épithelium intestinal chez le rat Wistar." Paris, AgroParisTech, 2008. http://www.theses.fr/2008AGPT0001.
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Les protéines alimentaires se trouvent principalement dans des aliments traditionnels d’origine animale et végétale. L’évaluation de la qualité nutritionnelle de différents sources de protéines alimentaires consiste à mettre en relation les caractéristiques de l’apport alimentaire et les caractéristiques de la demande métabolique concept relatif à l’état de l’individu. La recommandation de base WHO/UNU est de 0,8g /kg /j de protéine de bonne qualité pour l’homme adulte. L’objet de ce travail est d’évaluer les conséquences d’une adaptation à un régime hyperprotéique sur des modifications fonctionnelles et morphologique chez le rat en croissance. Plus particulièrement, on a analysé les effets d’un régime à 50% en protéines sur l’évolution du poids corporel, le poids de certains organes ainsi que sur la structure intestinale du rat. Dans ce but, 96 rats mâles de souche wistar pesant entre 175 et 185g (180±2,27g), sont répartis en 5 groupes : le 1er groupe (n=30) reçoit un régime normoprotéique à base de protéine totale de lait (14%) et constitue le groupe témoin, le 2ème groupe (n=30) reçoit un régime hyperprotéique (50%) à base de protéine totale de lait, le 3ème groupe (n=12) reçoit un régime normoprotéique (14,5%) à base de protéine végétale onab , le 4ème groupe (n=12) reçoit un régime hyperprotéique (50%) à base de protéine de soja, le 5ème groupe (n=12) reçoit un régime hyperprotéique (50%) à base de gluten. Tous ces régimes sont administrés pendant 60 jours, durée de l’expérimentation. Les résultats montrent qu’une surconsommation de protéines s’accompagne d’une diminution significative du poids corporel et d’une modification de la structure histologique de l’épithélium intestinal qui se traduit par une atrophie villositaire et par une augmentation des lymphocytes intra-épithéliaux. Ces modifications seraient la manifestation de phénomènes induits par l’exposition chronique de l’épithélium intestinal à des teneurs élevés en protéines. Nous avons conclu qu’une surconsommation de protéines n’est pas sans conséquence sur la composition corporelle et la fonction intestinale. Il convient donc d’observer une certaine prudence dans l’utilisation à long terme de formules diététiques enrichies en protéines chez l’hommeDietary proteins are derived from animal and plant food stuff. The evaluation of the nutritional quality of dietary proteins of different sources consists of relating the characteristics of food intake and energy requirement of the organism. The recommendation by WHO/UNU is of 0. 8g/kg/day of high quality protein for the adult man. This work aims to evaluate the consequences of a high-protein diet on the functional and morphological modification in the growing rat. In particular, we measure the effect of a 50% protein diet on body weight, weight of several organs and intestinal structure. For that purpose, 96 male wistar rats weighing between 175 and 185g (180±2,27g) are divided in 5 groups. The 1st group (n=30) receives an averageprotein level diet (14%) and constitutes the control group. The 2nd group (n=12) receives an highprotein diet (50%) The 3rd group (n=12) receives a diet based on plant proteins (14. 5%) the 4th group (n=12) receives a diet based on soya (50%) the 5th group (n=12) receives a diet based on gluten (50%). All diets are administered during a period of 60 days. Our results show that a high intake of dietary proteins results in significant body weight loss and causes modification of the histological structure of the intestinal epithelium, with an atrophy of the villaea accompanied with an important increase of intra-epithelial lymphocytes. 2These modifications could be the consequence of toxic reactions induced by a chronic/regular exposure of the intestinal epithelium to high levels/quantities of proteins. We conclude that an over-consumption of proteins has consequences on the body composition and intestinal function. Therefore, the long-term use of high-protein diets in man should be monitored more closely
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Addou, Benounan Samia. "Conséquences de l'adaptation à un régime hyperprotéique sur la structure de l'épithélium intestinal chez le rat Wistar." Phd thesis, AgroParisTech, 2008. http://pastel.archives-ouvertes.fr/pastel-00004489.
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Les protéines alimentaires se trouvent principalement dans des aliments traditionnels d'origine animale et végétale. L'évaluation de la qualité nutritionnelle de différents sources de protéines alimentaires consiste à mettre en relation les caractéristiques de l'apport alimentaire et les caractéristiques de la demande métabolique concept relatif à l'état de l'individu. La recommandation de base WHO/UNU est de 0,8g /kg /j de protéine de bonne qualité pour l'homme adulte. L'objet de ce travail est d'évaluer les conséquences d'une adaptation à un régime hyperprotéique sur des modifications fonctionnelles et morphologique chez le rat en croissance. Plus particulièrement, on a analysé les effets d'un régime à 50% en protéines sur l'évolution du poids corporel, le poids de certains organes ainsi que sur la structure intestinale du rat. Dans ce but, 96 rats mâles de souche wistar pesant entre 175 et 185g (180±2,27g), sont répartis en 5 groupes : le 1er groupe (n=30) reçoit un régime normoprotéique à base de protéine totale de lait (14%) et constitue le groupe témoin, le 2ème groupe (n=30) reçoit un régime hyperprotéique (50%) à base de protéine totale de lait, le 3ème groupe (n=12) reçoit un régime normoprotéique (14,5%) à base de protéine végétale onab , le 4ème groupe (n=12) reçoit un régime hyperprotéique (50%) à base de protéine de soja, le 5ème groupe (n=12) reçoit un régime hyperprotéique (50%) à base de gluten. Tous ces régimes sont administrés pendant 60 jours, durée de l'expérimentation. Les résultats montrent qu'une surconsommation de protéines s'accompagne d'une diminution significative du poids corporel et d'une modification de la structure histologique de l'épithélium intestinal qui se traduit par une atrophie villositaire et par une augmentation des lymphocytes intra-épithéliaux. Ces modifications seraient la manifestation de phénomènes induits par l'exposition chronique de l'épithélium intestinal à des teneurs élevés en protéines. Nous avons conclu qu'une surconsommation de protéines n'est pas sans conséquence sur la composition corporelle et la fonction intestinale. Il convient donc d'observer une certaine prudence dans l'utilisation à long terme de formules diététiques enrichies en protéines chez l'homme.
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Grigoriadou, Kalliopi. "Sélection du répertoire TCR exprimé par les cellules T gamma delta dans le thymus et l'épithélium intestinal de la souris." Paris 6, 2002. http://www.theses.fr/2002PA066164.
Full textBook chapters on the topic "Intra-intestinal"
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Onderdonk, Andrew B. "The intestinal microflora and intra-abdominal sepsis." In Medical Importance of the Normal Microflora, 164–76. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4757-3021-0_7.
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Schöffel, U., W. Sendt, R. Häring, and E. H. Farthmann. "Indications and Therapeutic Strategy for Intestinal Obstruction Due to Intra-abdominal Adhesions." In Peritoneal Adhesions, 271–77. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60433-1_33.
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"Agents Active Against Intestinal and Intra-Abdominal Protozoa." In Kucers' The Use of Antibiotics Sixth Edition, 2105. CRC Press, 2010. http://dx.doi.org/10.1201/b13787-202.
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Dias de Oliveira Reis, Luciano, Marcos Ricardo da Silva Rodrigues, Celso Augusto Milani Cardoso Filho, Cassiana Franco Dias dos Reis, and Alex Antonio de Paula Costa. "Inflammatory Complication of Diverticular Disease." In Diverticular Disease of the Colon - Recent Knowledge of Physiopathology, Endoscopic Approaches, Clinical and Surgical Treatments. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.100460.
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Diverticular disease is the most common morphological abnormality of the colon. It is increasing in prevalence proportionally to progressive aging and modern alimentary diet. The majority of the diverticular disease affects the sigmoid colon and the segmental inflammatory process can have different outcomes, from self-limited, low-grade inflammation to severe cases evolving to complications such as abscess, fistulas to different organs, free perforation and peritonitis, sepsis, intestinal obstruction, and hemorrhage. In this chapter, we will focus on a few of these complications—focal low-grade inflammation, intra-abdominal abscess, and fistulas.
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Cristina Ferreira, Ana, Marcelo Freire, Vanessa Siqueira, Carolina Ferreira, and Maria Teresa Santos. "Brain Injury and Neuroinflammation of the Gut-Brain Axis in Subjects with Cerebral Palsy." In Advancement and New Understanding in Brain Injury [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95763.
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Cerebral Palsy (CP) is a limiting deficiency, characterized by a permanent neuromotor disorder which affects movements, resulting in non-progressive lesions of the immature brain during the neuro psychomotor stages. Epidemiological studies of premature births correlated with the presence of high levels of inflammation in the umbilical cord, amniotic fluid, and fetal blood, being that one of the most relevant underlying physiopathological mechanisms includes inflammation and intra-amniotic infection, with inflammatory response and damage to the developing brain. Recently attributed to the excessive production of cytokines, CP inflammation is mostly modulated through diet restriction, intestinal dysfunction, and drug intake. The high prevalence of convulsive crises in individuals with CP (77%) on its own does not bring about post inflammatory and post convulsive cytokine synthesis, treated with antiepileptic medication. In these individuals, there is high incidence of intestinal constipation (47%), besides oral dysbiosis, gingival bleeding and even greater increase in chronic inflammation. The dysbiosis causes an increase in mucous permeability (leaky-gut) of the gut-brain axis, and increase in seric endotoxin, demonstrating a persistent inflammatory state, and supporting the emergence of new side effects, which can become the object of future research.
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Bedford, Matthew R., and Sharad Karandikar. "Current concepts in intra-abdominal adhesions." In Abdominal Trauma, Peritoneum, and Retroperitoneum, edited by Aditya J. Nanavati, Sanjay Nagral, Samiran Nundy, and Dirk J. Gouma, 163—C12.P178. Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/med/9780192862433.003.0012.
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Abstract Adhesions remain one of the more challenging issues in surgical practice. This is in part due to the fact that the density of their formation, time interval to subsequent development of symptoms, and severity of clinical presentation are variable. Although the majority of adhesions are clinically silent, the consequences of adhesion formation can represent a life-long problem including chronic abdominal pain, recurrent intestinal obstruction, and infertility. Moreover, adhesive disease can become a chronic medical condition with significant morbidity and without effective therapy. The aim of this chapter is to review the aetiology and pathophysiology behind adhesion formation, with particular emphasis on post-operative adhesions. The spectrum of clinical presentations will also be discussed, along with strategies for their management. Finally, an overview of recent advances in prevention strategies for development of post-operative adhesions will be discussed.
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N. Mohite, Prashant, Kavita Dave, Anna Reed, and André R. Simon. "Lung Transplantation in Patients with Cystic Fibrosis." In Cystic Fibrosis - Facts, Management and Advances. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.94523.
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Cystic fibrosis (CF) is one of the most common indications for lung transplant (LTx) and nearly one-third of the LTx worldwide are performed in people with CF (PwCF). Due to vast developments in diagnostic modalities, antibiotic therapies, and management of associated comorbidities in dedicated and experienced centres, over the past few decades, more PwCF are reaching adulthood than ever before. This has increased the burden on transplant programs particularly in a universal donor shortage scenario. To improve the donor pool a diligent and proactive donor care management, acceptance of marginal organs and utilisation of ex-vivo lung perfusion systems for organ preservation, assessment, and improvement is being advocated widely. LTx is not a readily available therapy and the average waiting time is 18 months in the UK. Therefore, it is essential that PwCF are referred for LTx assessment when their disease is stable, before respiratory deterioration leads to overall deconditioning of the patients. Once listed for LTx, it is crucial to control waiting list mortality by prioritising rapidly deteriorating patients through schemes like the lung allocation score, national urgent and super-urgent waiting lists, and institutional highlighting of deteriorating patients that do not meet other urgent criteria. LTx in PwCF is challenging due to colonisation of the respiratory tract with multi-drug resistant organisms, associated comorbidities such as diabetes, liver disease, gastro-oesophageal reflux, and distal intestinal obstruction syndrome (DIOS) and CF-specific technical difficulties (adhesions due to prior pneumothoraces or pleurodesis, or bronchial collaterals that increase surgical time). Hilar lymphadenopathy and bronchial collaterals may increase surgical time, organ ischemia time, intra and post-operative bleeding, and blood transfusions. Advances in immunosuppression, prophylactic anti-viral and anti-fungal therapies, early ambulation and rigorous physiotherapy, and meticulous postoperative follow up with spirometry, x-rays, and bronchoscopies to detect rejection at the early stage followed by its efficient treatment have helped to improve post-LTx survival in the CF patients. Constant development in the surgical field with adoption of off-pump transplantation, sternal sparing bilateral thoracotomy approach, and utilisation of mechanical circulatory assist as a bridge to transplant and as a support for primary graft failure strives for better outcomes. However, chronic lung allograft dysfunction, chronic refractory infections, malignancies, and CF associated comorbidities remain major determinants of post-LTx long term survival. Despite this, CF patients are often good candidates for re-do LTx with improving survival outcomes. In this chapter, we are compiling the different aspects of LTx in PwCF emphasising the advances in bridge to transplantation, the surgical approach, management of primary graft failure, and immunosuppression as well as complications post-transplant.
Reports on the topic "Intra-intestinal"
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Jangir, Hemlata, Aparna Ningombam, Arulselvi Subramanian, and Subodh Kumar. Traumatic Jejunal Mesenteric Pseudocyst in the Vicinity of Blunt Abdominal Trauma with a Brief Review of Literature. Science Repository, January 2023. http://dx.doi.org/10.31487/j.ajscr.2022.04.04.
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Mesenteric pseudocyst (MP) is a rare heterogeneous group of intra-abdominal benign cystic lesions with different etiopathogenesis and clinically silent behaviours. These lesions are introduced as one of the entities based on the histological features of thick fibrous cyst walls, barren of the epithelial lining. Often, they present as expanding abdominal masses or are diagnosed incidentally in conventional radiological studies, exploratory laparotomies, or with symptoms of complications such as infection, torsion, or rupture. Surgical removal of the cyst, with or without resection of the affected intestinal segment, is the treatment of choice. Depending upon the size and location of the lesion and related complications, it can be managed by open surgical procedures or laparoscopic approach. Only a handful of 7 cases of traumatic mesenteric cysts have been reported yet in the vicinity of blunt abdominal trauma. We report a rare incidentally detected case of mesenteric pseudocyst (traumatic) in a male of early 20s with a history of blunt abdominal trauma 13 months back and for which serial abdominal exploratory laparotomies were performed. A brief review of the literature is provided, conforming to the rarity of the case. This case highlights the role of histomorphology in diagnosing a benign cystic entity with accuracy, that could be misdiagnosed as infectious granulomatous lesion.