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Journal articles on the topic 'Intestinal brain microbiota axis'

Author: Grafiati

Published: 18 May 2024

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1

Zamudio Tiburcio, Alvaro, Héctor Bermudez Ruiz, Silverio Alonso Lopez, and Pedro Antonio Reyes Lopez. "Breast Cancer and Intestinal Microbiota Transplantation." Journal of Clinical Research and Clinical Trials 2, no. 3 (2023): 1–8. http://dx.doi.org/10.59657/2837-7184.brs.23.018.

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Breast cancer has been studied relating it to the intestinal microbiota and its own microbiota. Giving a primary role to the dysbiosis that occurs in both the mammary gland and the intestine. Likewise, metabolic processes and immunological eventualities have been considered as determining factors; By the way, many of them are determined by the intestinal microbiota itself, which is given the deserved name of endocrine gland, because it acts at a distance, and it is not only the super-organ or the new organ, but the multiple studies have generated this honorable new consideration. We break down

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Góralczyk-Bińkowska, Aleksandra, Dagmara Szmajda-Krygier, and Elżbieta Kozłowska. "The Microbiota–Gut–Brain Axis in Psychiatric Disorders." International Journal of Molecular Sciences 23, no. 19 (2022): 11245. http://dx.doi.org/10.3390/ijms231911245.

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Modulating the gut microbiome and its influence on human health is the subject of intense research. The gut microbiota could be associated not only with gastroenterological diseases but also with psychiatric disorders. The importance of factors such as stress, mode of delivery, the role of probiotics, circadian clock system, diet, and occupational and environmental exposure in the relationship between the gut microbiota and brain function through bidirectional communication, described as “the microbiome–gut–brain axis”, is especially underlined. In this review, we discuss the link between the

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Kohl, Hannah M., Andrea R. Castillo, and Javier Ochoa-Repáraz. "The Microbiome as a Therapeutic Target for Multiple Sclerosis: Can Genetically Engineered Probiotics Treat the Disease?" Diseases 8, no. 3 (2020): 33. http://dx.doi.org/10.3390/diseases8030033.

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There is an increasing interest in the intestinal microbiota as a critical regulator of the development and function of the immune, nervous, and endocrine systems. Experimental work in animal models has provided the foundation for clinical studies to investigate associations between microbiota composition and function and human disease, including multiple sclerosis (MS). Initial work done using an animal model of brain inflammation, experimental autoimmune encephalomyelitis (EAE), suggests the existence of a microbiota–gut–brain axis connection in the context of MS, and microbiome sequence ana

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Blagonravova, A. S., E. A. Galova, I. Yu Shirokova, and D. A. Galova. "The gut-brain axis — clinical study results." Experimental and Clinical Gastroenterology, no. 6 (July 25, 2023): 5–13. http://dx.doi.org/10.31146/1682-8658-ecg-214-6-5-13.

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The aim of the study was to investigate the intestinal microbiome in children with autism spectrum disorders (ASD). The study was observational, cohort, comparative. All the patients included in it were divided into 2 groups. The first (comparison group main) group (n=43) consisted of children preschool aged of 1 and 2 health groups; the second (n=38, main group) children with an established diagnosis of ASD. It was stated that children with ASD are characterized by the most frequent (p=0.001) detection of intestinal dysbiosis; the detection of significant disorders in the form of intestinal d

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Obrenovich, Mark, and V. Prakash Reddy. "Special Issue: Microbiota–Gut–Brain Axis." Microorganisms 10, no. 2 (2022): 309. http://dx.doi.org/10.3390/microorganisms10020309.

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Derovs, Aleksejs, Sniedze Laivacuma, and Angelika Krumina. "Targeting Microbiota: What Do We Know about It at Present?" Medicina 55, no. 8 (2019): 459. http://dx.doi.org/10.3390/medicina55080459.

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The human microbiota is a variety of different microorganisms. The composition of microbiota varies from host to host, and it changes during the lifetime. It is known that microbiome may be changed because of a diet, bacteriophages and different processes for example, such as inflammation. Like all other areas of medicine, there is a continuous growth in the area of microbiology. Different microbes can reside in all sites of a human body, even in locations that were previously considered as sterile; for example, liver, pancreas, brain and adipose tissue. Presently one of the etiological factor

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Mohamadkhani, Ashraf. "Gut Microbiota and Fecal Metabolome Perturbation in Children with Autism Spectrum Disorder." Middle East Journal of Digestive Diseases 10, no. 4 (2018): 205–12. http://dx.doi.org/10.15171/mejdd.2018.112.

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The brain-intestinal axis concept describes the communication between the intestinal microbiota as an ecosystem of a number of dynamic microorganisms and the brain. The composition of the microbial community of the human gut is important for human health by influencing the total metabolomic profile. In children with autism spectrum disorder (ASD), the composition of the fecal microbiota and their metabolic products has a different configuration of the healthy child. An imbalance in the metabolite derived from the microbiota in children with ASD affect brain development and social behavior. In

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Kharchenko, Yu V., H. I. Titov, D. H. Kryzhanovskyi, et al. "Stress and the Gut-Brain Axis." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 7, no. 4 (2022): 137–46. http://dx.doi.org/10.26693/jmbs07.04.137.

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The purpose of the review was to study the effects of stress on the gut microbiota. Results and discussion. The gut microbiota forms a complex microbial community that has a significant impact on human health. The composition of the microbiota varies from person to person, and it changes throughout life. It is known that the microbiome can be altered due to diet, various processes, such as inflammation and/or stress. Like all other areas of medicine, microbiology is constantly growing. The gut microbiota lives in a symbiotic relationship with the human host. It is now believed to interact with

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GIURGIU, Gheorghe, and Manole COJOCARU. "Natural Neuroimunomodulation in Coronavirus Infection." Annals of the Academy of Romanian Scientists Series on Biological Sciences 9, no. 2 (2020): 80–87. http://dx.doi.org/10.56082/annalsarscibio.2020.2.80.

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Dysbiosis of the nasopharyngeal microbiome attracts dysbiosis of the intestinal microbiome and activation of the intestinal microbiome-brain axis. If the first sign of the disease is quickly intervened with the modulation of the activity of the microbiome, implicitly of the immune system (neuroimmunomodulation), the appearance of the disease is eliminated. There is the microbiome: buccal, nasal, intestinal, cardiac, cutaneous and even the microbiome in the brain with which Covid-19 interacts. When the evolution is complicated, it is necessary to intervene with drug treatment to support the aff

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Bogdanova, Natalia M., and Kira A. Kravtsova. "INTESTINAL MICROBIOME. EPILEPSY AND THE POSSIBILITY OF EXPANDING ALTERNATIVE THERAPIES." Medical Scientific Bulletin of Central Chernozemye (Naučno-medicinskij vestnik Centralʹnogo Černozemʹâ) 24, no. 3 (2023): 107–21. http://dx.doi.org/10.18499/1990-472x-2023-24-3-107-121.

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The development of sequencing technology indicates a key regulatory role for the gut microbiota in several neurological disorders, including epilepsy. The microbiota-gut-brain axis refers to the bi-directional communication between the gut and the brain and regulates gut and central nervous system homeostasis through neural networks, neuroendocrine, immune and inflammatory pathways. The present review discusses the relationship between the gut microbiota and epilepsy, possible pathogenic mechanisms of epilepsy in terms of the microbiota-gut-brain axis, and alternative therapies targeting the g

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Smith, Carli J., Jacob R. Emge, Katrina Berzins, et al. "Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 307, no. 8 (2014): G793—G802. http://dx.doi.org/10.1152/ajpgi.00238.2014.

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The gut-brain-microbiota axis is increasingly recognized as an important regulator of intestinal physiology. Exposure to psychological stress causes activation of the hypothalamic-pituitary-adrenal (HPA) axis and causes altered intestinal barrier function, intestinal dysbiosis, and behavioral changes. The primary aim of this study was to determine whether the effects of psychological stress on intestinal physiology and behavior, including anxiety and memory, are mediated by the adaptive immune system. Furthermore, we wanted to determine whether treatment with probiotics would normalize these e

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Zhu, Fangyuan, Huaijun Tu, and Tingtao Chen. "The Microbiota–Gut–Brain Axis in Depression: The Potential Pathophysiological Mechanisms and Microbiota Combined Antidepression Effect." Nutrients 14, no. 10 (2022): 2081. http://dx.doi.org/10.3390/nu14102081.

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Depression is a kind of worldwide mental illness with the highest morbidity and disability rate, which is often accompanied by gastrointestinal symptoms. Experiments have demonstrated that the disorder of the intestinal microbial system structure plays a crucial role in depression. The gut–brain axis manifests a potential linkage between the digestion system and the central nervous system (CNS). Nowadays, it has become an emerging trend to treat diseases by targeting intestinal microorganisms (e.g., probiotics) and combining the gut–brain axis mechanism. Combined with the research, we found th

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Pluta, Ryszard, Sławomir Januszewski, and Stanisław J. Czuczwar. "The Role of Gut Microbiota in an Ischemic Stroke." International Journal of Molecular Sciences 22, no. 2 (2021): 915. http://dx.doi.org/10.3390/ijms22020915.

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The intestinal microbiome, the largest reservoir of microorganisms in the human body, plays an important role in neurological development and aging as well as in brain disorders such as an ischemic stroke. Increasing knowledge about mediators and triggered pathways has contributed to a better understanding of the interaction between the gut-brain axis and the brain-gut axis. Intestinal bacteria produce neuroactive compounds and can modulate neuronal function, which affects behavior after an ischemic stroke. In addition, intestinal microorganisms affect host metabolism and immune status, which

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He, Qinghui, Congcong Si, Zhenjiao Sun, Yuhui Chen, and Xin Zhang. "The Intervention of Prebiotics on Depression via the Gut–Brain Axis." Molecules 27, no. 12 (2022): 3671. http://dx.doi.org/10.3390/molecules27123671.

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The imbalance of intestinal microbiota can cause the accumulation of endotoxin in the main circulation system of the human body, which has a great impact on human health. Increased work and life pressure have led to a rise in the number of people falling into depression, which has also reduced their quality of life. The gut–brain axis (GBA) is closely related to the pathological basis of depression, and intestinal microbiota can improve depressive symptoms through GBA. Previous studies have proven that prebiotics can modulate intestinal microbiota and thus participate in human health regulatio

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Marano, Giuseppe, Marianna Mazza, Francesco Maria Lisci, et al. "The Microbiota–Gut–Brain Axis: Psychoneuroimmunological Insights." Nutrients 15, no. 6 (2023): 1496. http://dx.doi.org/10.3390/nu15061496.

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There is growing interest in the role that the intestinal microbiota and the related autoimmune processes may have in the genesis and presentation of some psychiatric diseases. An alteration in the communication of the microbiota–gut–brain axis, which constitutes a communicative model between the central nervous system (CNS) and the gastro-enteric tract, has been identified as one of the possible causes of some psychiatric diseases. The purpose of this narrative review is to describe evidence supporting a role of the gut microbiota in psychiatric diseases and the impact of diet on microbiota a

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Singh, Samradhi, Poonam Sharma, Namrata Pal, et al. "Impact of Environmental Pollutants on Gut Microbiome and Mental Health via the Gut–Brain Axis." Microorganisms 10, no. 7 (2022): 1457. http://dx.doi.org/10.3390/microorganisms10071457.

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Over the last few years, the microbiome has emerged as a high-priority research area to discover missing links between brain health and gut dysbiosis. Emerging evidence suggests that the commensal gut microbiome is an important regulator of the gut–brain axis and plays a critical role in brain physiology. Engaging microbiome-generated metabolites such as short-chain fatty acids, the immune system, the enteric nervous system, the endocrine system (including the HPA axis), tryptophan metabolism or the vagus nerve plays a crucial role in communication between the gut microbes and the brain. Human

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Nikolovska-Trpčevska, Emilija. "The role of the connection between intestinal microbiota and brain in the pathogenesis of functional gastrointestinal disorders." Galenika Medical Journal 2, no. 5 (2023): 75–80. http://dx.doi.org/10.5937/galmed2305075n.

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The relation between the intestinal microbiota and the brain is an important field of research in the pathophysiology of functional gastrointestinal disorders (FGIDs). This group of diseases includes more than 40% of the population and is one of the most common reasons for the need of consulting a gastroenterologist. The interaction between the gut microbiota and the brain is a new terminology for defining functional gastrointestinal disorders, based on certain diagnostic criteria. The ROMA IV classification of diagnostic criteria divides functional gastrointestinal diseases into five anatomic

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Muhammad, Fahim, Bufang Fan, Ruoxi Wang, et al. "The Molecular Gut-Brain Axis in Early Brain Development." International Journal of Molecular Sciences 23, no. 23 (2022): 15389. http://dx.doi.org/10.3390/ijms232315389.

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Millions of nerves, immune factors, and hormones in the circulatory system connect the gut and the brain. In bidirectional communication, the gut microbiota play a crucial role in the gut-brain axis (GBA), wherein microbial metabolites of the gut microbiota regulate intestinal homeostasis, thereby influencing brain activity. Dynamic changes are observed in gut microbiota as well as during brain development. Altering the gut microbiota could serve as a therapeutic target for treating abnormalities associated with brain development. Neurophysiological development and immune regulatory disorders

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Skowron, Krzysztof, Anna Budzyńska, Natalia Wiktorczyk-Kapischke, et al. "The Role of Psychobiotics in Supporting the Treatment of Disturbances in the Functioning of the Nervous System—A Systematic Review." International Journal of Molecular Sciences 23, no. 14 (2022): 7820. http://dx.doi.org/10.3390/ijms23147820.

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Stress and anxiety are common phenomena that contribute to many nervous system dysfunctions. More and more research has been focusing on the importance of the gut–brain axis in the course and treatment of many diseases, including nervous system disorders. This review aims to present current knowledge on the influence of psychobiotics on the gut–brain axis based on selected diseases, i.e., Alzheimer’s disease, Parkinson’s disease, depression, and autism spectrum disorders. Analyses of the available research results have shown that selected probiotic bacteria affect the gut–brain axis in healthy

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Jach, Monika Elżbieta, Anna Serefko, Aleksandra Szopa, et al. "The Role of Probiotics and Their Metabolites in the Treatment of Depression." Molecules 28, no. 7 (2023): 3213. http://dx.doi.org/10.3390/molecules28073213.

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Depression is a common and complex mental and emotional disorder that causes disability, morbidity, and quite often mortality around the world. Depression is closely related to several physical and metabolic conditions causing metabolic depression. Studies have indicated that there is a relationship between the intestinal microbiota and the brain, known as the gut–brain axis. While this microbiota–gut–brain connection is disturbed, dysfunctions of the brain, immune system, endocrine system, and gastrointestinal tract occur. Numerous studies show that intestinal dysbiosis characterized by abnor

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Del Negro, Ilaria, Sara Pez, Salvatore Versace, et al. "Impact of Disease-Modifying Therapies on Gut–Brain Axis in Multiple Sclerosis." Medicina 60, no. 1 (2023): 6. http://dx.doi.org/10.3390/medicina60010006.

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Multiple sclerosis is a chronic, autoimmune-mediated, demyelinating disease whose pathogenesis remains to be defined. In past years, in consideration of a constantly growing number of patients diagnosed with multiple sclerosis, the impacts of different environmental factors in the pathogenesis of the disease have been largely studied. Alterations in gut microbiome composition and intestinal barrier permeability have been suggested to play an essential role in the regulation of autoimmunity. Thus, increased efforts are being conducted to demonstrate the complex interplay between gut homeostasis

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Zhong, Hao, Jie Xu, Mengyu Yang, et al. "Protective Effect of Anthocyanins against Neurodegenerative Diseases through the Microbial-Intestinal-Brain Axis: A Critical Review." Nutrients 15, no. 3 (2023): 496. http://dx.doi.org/10.3390/nu15030496.

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With the increase in human mean age, the prevalence of neurodegenerative diseases (NDs) also rises. This negatively affects mental and physiological health. In recent years, evidence has revealed that anthocyanins could regulate the functioning of the central nervous system (CNS) through the microbiome-gut-brain axis, which provides a new perspective for treating NDs. In this review, the protective effects and mechanisms of anthocyanins against NDs are summarized, especially the interaction between anthocyanins and the intestinal microbiota, and the microbial-intestinal-brain axis system is co

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Cerdó, Tomás, Estefanía Diéguez, and Cristina Campoy. "Early nutrition and gut microbiome: interrelationship between bacterial metabolism, immune system, brain structure, and neurodevelopment." American Journal of Physiology-Endocrinology and Metabolism 317, no. 4 (2019): E617—E630. http://dx.doi.org/10.1152/ajpendo.00188.2019.

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Disturbances of diet during pregnancy and early postnatal life may impact colonization of gut microbiota during early life, which could influence infant health, leading to potential long-lasting consequences later in life. This is a nonsystematic review that explores the recent scientific literature to provide a general perspective of this broad topic. Several studies have shown that gut microbiota composition is related to changes in metabolism, energy balance, and immune system disturbances through interaction between microbiota metabolites and host receptors by the gut-brain axis. Moreover,

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Kulchavenya, Ekaterina V. "Minerals contributing to human health and well-being." Clinical review for general practice 2, no. 1 (2021): 58–64. http://dx.doi.org/10.47407/kr2021.2.1.00033.

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The gut microbiome is vital for normal human body functioning. The etiological and pathogenetic significance of increased intestinal permeability in disorders of various organs and systems seems to be certain. The term “microbiota-gut-brain axis” has been defined; the crucial role of the microbiota-gut-brain axis in neurological disorders has been confirmed. Gut microbiome not only contributes to digestion, metabolism and immunity, but also mediates sleep and mental health of the host via microbiota-gut-brain axis. Such elements as zinc and selenium are essential to maintain the microbial bala

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Mishima, Yoshiyuki, and Shunji Ishihara. "Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome." International Journal of Molecular Sciences 22, no. 19 (2021): 10235. http://dx.doi.org/10.3390/ijms221910235.

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Irritable bowel syndrome (IBS) is a chronic functional disorder that affects the gastrointestinal tract. Details regarding the pathogenesis of IBS remain largely unknown, though the dysfunction of the brain-gut-microbiome (BGM) axis is a major etiological factor, in which neurotransmitters serve as a key communication tool between enteric microbiota and the brain. One of the most important neurotransmitters in the pathology of IBS is serotonin (5-HT), as it influences gastrointestinal motility, pain sensation, mucosal inflammation, immune responses, and brain activity, all of which shape IBS f

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Bercik, P. "The microbiota-gut-brain axis: learning from intestinal bacteria?" Gut 60, no. 3 (2011): 288–89. http://dx.doi.org/10.1136/gut.2010.226779.

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Zhang, Zhicheng, Yuting Zhang, Junmin Li, Chengxin Fu, and Xin Zhang. "The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora." Molecules 26, no. 12 (2021): 3692. http://dx.doi.org/10.3390/molecules26123692.

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Tea polyphenols (TPs) are the general compounds of natural polyhydroxyphenols extracted in tea. Although a large number of studies have shown that TPs have obvious neuroprotective and neuro repair effects, they are limited due to the low bioavailability in vivo. However, TPs can act indirectly on the central nervous system by affecting the “microflora–gut–brain axis”, in which the microbiota and its composition represent a factor that determines brain health. Bidirectional communication between the intestinal microflora and the brain (microbe–gut–brain axis) occurs through a variety of pathway

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Wang, Shumeng, Junyi Luo, Hailong Wang, et al. "Extracellular Vesicles: A Crucial Player in the Intestinal Microenvironment and Beyond." International Journal of Molecular Sciences 25, no. 6 (2024): 3478. http://dx.doi.org/10.3390/ijms25063478.

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The intestinal ecological environment plays a crucial role in nutrient absorption and overall well-being. In recent years, research has focused on the effects of extracellular vesicles (EVs) in both physiological and pathological conditions of the intestine. The intestine does not only consume EVs from exogenous foods, but also those from other endogenous tissues and cells, and even from the gut microbiota. The alteration of conditions in the intestine and the intestinal microbiota subsequently gives rise to changes in other organs and systems, including the central nervous system (CNS), namel

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Zhang, Li, Zhenying Zhang, Lei Xu, and Xin Zhang. "Maintaining the Balance of Intestinal Flora through the Diet: Effective Prevention of Illness." Foods 10, no. 10 (2021): 2312. http://dx.doi.org/10.3390/foods10102312.

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The human body is home to a complex community of dynamic equilibrium microbiota, including bacteria, fungi, parasites, and viruses. It is known that the gut microbiome plays a crucial role in regulating innate and adaptive immune responses, intestinal peristalsis, intestinal barrier homeostasis, nutrient uptake, and fat distribution. The complex relationship between the host and microbiome suggests that when this relationship is out of balance, the microbiome may contribute to disease development. The brain–gut–microbial axis is composed of many signal molecules, gastrointestinal mucosal cells

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Shaikh, Sofia D., Natalie Sun, Andrew Canakis, William Y. Park, and Horst Christian Weber. "Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review." Journal of Clinical Medicine 12, no. 7 (2023): 2558. http://dx.doi.org/10.3390/jcm12072558.

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Irritable Bowel Syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal pain and altered bowel habits. It has a prevalence of 10 to 25% in the United States and has a high disease burden, as evidenced by reduced quality of life, decreased work productivity and increased healthcare utilization and costs. IBS has been associated with several intra-intestinal and extra-intestinal conditions, including psychiatric comorbidities. Although the pathophysiology of IBS has not been fully elucidated, it involves dysregulation of communication between the brain an

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Dziedzic, Angela, Karina Maciak, Katarzyna Bliźniewska-Kowalska, Małgorzata Gałecka, Weronika Kobierecka, and Joanna Saluk. "The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A literature Review." Nutrients 16, no. 7 (2024): 1054. http://dx.doi.org/10.3390/nu16071054.

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The microbiota–gut–brain (MGB) axis is a complex communication network linking the gut, microbiota, and brain, influencing various aspects of health and disease. Dysbiosis, a disturbance in the gut microbiome equilibrium, can significantly impact the MGB axis, leading to alterations in microbial composition and function. Emerging evidence highlights the connection between microbiota alterations and neurological and psychiatric disorders, including depression. This review explores the potential of psychobiotics in managing depressive disorders, emphasizing their role in restoring microbial bala

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Sabit, Hussein, Areej Kassab, Donia Alaa, et al. "The Effect of Probiotic Supplementation on the Gut–Brain Axis in Psychiatric Patients." Current Issues in Molecular Biology 45, no. 5 (2023): 4080–99. http://dx.doi.org/10.3390/cimb45050260.

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The pathophysiology of several psychiatric diseases may entail disturbances in the hypothalamic–pituitary–adrenal (HPA) axis and metabolic pathways. Variations in how these effects present themselves may be connected to individual variances in clinical symptoms and treatment responses, such as the observation that a significant fraction of participants do not respond to current antipsychotic drugs. A bidirectional signaling pathway between the central nervous system and the gastrointestinal tract is known as the microbiota–gut–brain axis. The large and small intestines contain more than 100 tr

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Chen, Keyin, Yuchen Wei, and Tianhao Xing. "The Gut Microbiota Dysbiosis as a Trigger of Inflammation-Driving Pathogensis of Alzheimer’s Disease." Highlights in Science, Engineering and Technology 8 (August 17, 2022): 306–13. http://dx.doi.org/10.54097/hset.v8i.1169.

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Alzheimer's disease (AD) is a degenerative disease of the central nervous system, and its pathogenesis is very complex. Gut microbiota is an immense and complicated microbial community that is regarded as the “second brain “by scientists. These microorganisms exist in the ecosystem of the gastrointestinal tract which is in the human body and form a relatively stable environment within the gastrointestinal tract. As a large number of microorganisms that can survive and coexist harmoniously in the human body, intestinal flora is a very important environmental factor and plays a very important ro

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Doroszkiewicz, Julia, Magdalena Groblewska, and Barbara Mroczko. "The Role of Gut Microbiota and Gut–Brain Interplay in Selected Diseases of the Central Nervous System." International Journal of Molecular Sciences 22, no. 18 (2021): 10028. http://dx.doi.org/10.3390/ijms221810028.

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The gut microbiome has attracted increasing attention from researchers in recent years. The microbiota can have a specific and complex cross-talk with the host, particularly with the central nervous system (CNS), creating the so-called “gut–brain axis”. Communication between the gut, intestinal microbiota, and the brain involves the secretion of various metabolites such as short-chain fatty acids (SCFAs), structural components of bacteria, and signaling molecules. Moreover, an imbalance in the gut microbiota composition modulates the immune system and function of tissue barriers such as the bl

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Zhou, Yingyu, Wanyi Qiu, Yimei Wang та ін. "β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis". Biomedicines 9, № 7 (2021): 704. http://dx.doi.org/10.3390/biomedicines9070704.

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As a kind of metabolically triggered inflammation, obesity influences the interplay between the central nervous system and the enteral environment. The present study showed that β-elemene, which is contained in various plant substances, had effects on recovering the changes in metabolites occurring in high-fat diet (HFD)-induced obese C57BL/6 male mice brains, especially in the prefrontal cortex (PFC) and hippocampus (HIP). β-elemene also partially reversed HFD-induced changes in the composition and contents of mouse gut bacteria. Furthermore, we evaluated the interaction between cerebral meta

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Wang, Shu-Zhi, Yi-Jing Yu, and Khosrow Adeli. "Role of Gut Microbiota in Neuroendocrine Regulation of Carbohydrate and Lipid Metabolism via the Microbiota-Gut-Brain-Liver Axis." Microorganisms 8, no. 4 (2020): 527. http://dx.doi.org/10.3390/microorganisms8040527.

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Gut microbiota play an important role in maintaining intestinal health and are involved in the metabolism of carbohydrates, lipids, and amino acids. Recent studies have shown that the central nervous system (CNS) and enteric nervous system (ENS) can interact with gut microbiota to regulate nutrient metabolism. The vagal nerve system communicates between the CNS and ENS to control gastrointestinal tract functions and feeding behavior. Vagal afferent neurons also express receptors for gut peptides that are secreted from enteroendocrine cells (EECs), such as cholecystokinin (CCK), ghrelin, leptin

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Xu, Fenghua, Yi Cheng, Guangcong Ruan, et al. "New pathway ameliorating ulcerative colitis: focus on Roseburia intestinalis and the gut–brain axis." Therapeutic Advances in Gastroenterology 14 (January 2021): 175628482110044. http://dx.doi.org/10.1177/17562848211004469.

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Background: The community of gut microbes is a key factor controlling the intestinal barrier that communicates with the nervous system through the gut–brain axis. Based on our clinical data showing that populations of Roseburia intestinalis are dramatically decreased in the gut of patients with ulcerative colitis, we studied the efficacy of a strain belonging to this species in the context of colitis and stress using animal models. Methods: Dextran sulfate sodium was used to induce colitis in rats, which then underwent an enema with R. intestinalis as a treatment. The disease activity index, f

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Zhong, Si-Ran, Qi Kuang, Fan Zhang, Ben Chen, and Zhen-Guo Zhong. "Functional roles of the microbiota-gut-brain axis in Alzheimer’s disease: Implications of gut microbiota-targeted therapy." Translational Neuroscience 12, no. 1 (2021): 581–600. http://dx.doi.org/10.1515/tnsci-2020-0206.

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Abstract Increasing scientific evidence demonstrates that the gut microbiota influences normal physiological homeostasis and contributes to pathogenesis, ranging from obesity to neurodegenerative diseases, such as Alzheimer’s disease (AD). Gut microbiota can interact with the central nervous system (CNS) through the microbiota-gut-brain axis. The interaction is mediated by microbial secretions, metabolic interventions, and neural stimulation. Here, we review and summarize the regulatory pathways (immune, neural, neuroendocrine, or metabolic systems) in the microbiota-gut-brain axis in AD patho

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Matsumura, Yoko, Masahiro Kitabatake, Shin-ichi Kayano, and Toshihiro Ito. "Dietary Phenolic Compounds: Their Health Benefits and Association with the Gut Microbiota." Antioxidants 12, no. 4 (2023): 880. http://dx.doi.org/10.3390/antiox12040880.

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Oxidative stress causes various diseases, such as type II diabetes and dyslipidemia, while antioxidants in foods may prevent a number of diseases and delay aging by exerting their effects in vivo. Phenolic compounds are phytochemicals such as flavonoids which consist of flavonols, flavones, flavanonols, flavanones, anthocyanidins, isoflavones, lignans, stilbenoids, curcuminoids, phenolic acids, and tannins. They have phenolic hydroxyl groups in their molecular structures. These compounds are present in most plants, are abundant in nature, and contribute to the bitterness and color of various f

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Lewandowska-Pietruszka, Zuzanna, Magdalena Figlerowicz, and Katarzyna Mazur-Melewska. "The History of the Intestinal Microbiota and the Gut-Brain Axis." Pathogens 11, no. 12 (2022): 1540. http://dx.doi.org/10.3390/pathogens11121540.

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The gut-brain axis and the intestinal microbiota have been an area of an intensive research in the last few years. However, it is not a completely novel area of interest for physicians and scientists. From the earliest centuries, both professionals and patients turned their attention to the gastrointestinal system in order to find the root of physical and mental disturbances. The approach to the gut-brain axis and the therapeutic methods have changed alongside the development of different medical approaches to health and illness. They often reflected the social changes. The authors of this art

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Taniguchi, Kurumi, Yuka Ikeda, Nozomi Nagase, Ai Tsuji, Yasuko Kitagishi, and Satoru Matsuda. "Implications of Gut-Brain axis in the pathogenesis of Psychiatric disorders." AIMS Bioengineering 8, no. 4 (2021): 243–56. http://dx.doi.org/10.3934/bioeng.2021021.

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<abstract> <p>Psychiatric disorders may extremely impair the quality of life with patients and are important reasons of social disability. Several data have shown that psychiatric disorders are associated with an altered composition of gut microbiota. Dietary intake could determine the microbiota, which contribute to produce various metabolites of fermentation such as short chain fatty acids. Some of the metabolites could result in epigenetic alterations leading to the disease susceptibility. Epigenetic dysfunction is in fact implicated in various psychiatric and neurologic disorde

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Andreeva, Irina V., A. V. Tolpygo, V. A. Andreev, et al. "Psychobiotics: a new way in psychopharmacology, or How do bacteria manage our brain?" Clinical Microbiology and Antimicrobial Chemotherapy 24, no. 2 (2022): 108–33. http://dx.doi.org/10.36488/cmac.2022.2.108-133.

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Psychobiotics are a special class of probiotics that have a beneficial effect on human mental health. During the last decade, convincing evidence has emerged that the gut microbiome influences mental health, cognitive abilities (learning and memory), and behavioral processes through neurological, metabolic, hormonal, and immunological signaling pathways. This review provides available information on the mechanisms of regulation of neuroimmune axes by the microbiota, describes the schemes of interaction of the microbiota with the intestinal nervous system and the brain-gut axis, the effect on b

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Marginean, Cristina Maria, Mihaela Popescu, Andrei Ioan Drocas, et al. "Gut–Brain Axis, Microbiota and Probiotics—Current Knowledge on Their Role in Irritable Bowel Syndrome: A Review." Gastrointestinal Disorders 5, no. 4 (2023): 517–35. http://dx.doi.org/10.3390/gidisord5040043.

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Irritable bowel syndrome (IBS) is a common digestive disorder with a significant impact on both individuals and society in terms of quality of life and healthcare costs. A growing body of research has identified various communication pathways between the microbiota and the brain in relation to motility disorders, with the gut–brain axis being key to the pathogenesis of IBS. Multiple factors contribute to the pathogenetic pathways in IBS, including immune mechanisms, psychosocial factors, increased oxidative stress and pro-inflammatory cytokine release, as well as genetic and hormonal factors.

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Murciano-Brea, Julia, Martin Garcia-Montes, Stefano Geuna, and Celia Herrera-Rincon. "Gut Microbiota and Neuroplasticity." Cells 10, no. 8 (2021): 2084. http://dx.doi.org/10.3390/cells10082084.

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The accumulating evidence linking bacteria in the gut and neurons in the brain (the microbiota–gut–brain axis) has led to a paradigm shift in the neurosciences. Understanding the neurobiological mechanisms supporting the relevance of actions mediated by the gut microbiota for brain physiology and neuronal functioning is a key research area. In this review, we discuss the literature showing how the microbiota is emerging as a key regulator of the brain’s function and behavior, as increasing amounts of evidence on the importance of the bidirectional communication between the intestinal bacteria

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Zhang, Yuan, Wanpeng Yu, Lei Zhang, Man Wang, and Wenguang Chang. "The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases." Nutrients 14, no. 24 (2022): 5373. http://dx.doi.org/10.3390/nu14245373.

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Polyphenols are secondary metabolites of plants and play a potential role in the prevention and treatment of neurodegenerative diseases (NND) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to their unique physiological functions such as acting as antioxidants, being anti-inflammatory, being neuroprotective, and promoting intestinal health. Since dietary polyphenols exist in plant foods in the form of glycosylation or esterification or are combined with polymers, they need to undergo extensive metabolism through phase I and phase II biotransformations by various intestinal en

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FAULIN, Tanize do Espirito Santo, and Debora ESTADELLA. "ALZHEIMER’S DISEASE AND ITS RELATIONSHIP WITH THE MICROBIOTA-GUT-BRAIN AXIS." Arquivos de Gastroenterologia 60, no. 1 (2023): 144–54. http://dx.doi.org/10.1590/s0004-2803.202301000-17.

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ABSTRACT Background: Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disease, characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. Several pathways enable bidirectional communication between the central nervous system (CNS), the intestine and its microbiota, constituting the microbiota-gut-brain axis. Objective: Review the pathophysiology of AD, relate it to the microbiota-gut-brain axis and discuss the possibility of using probiotics in the treatment and/or prevention of this disease. Methods: Search of articles from the P

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Vermehren, Cláudia Almeida Alves, and Tayna Ofelia Freitas Suarez. "Symbiosis in the microbiome of people with asd and its effects on the brain-intestine linkage." Research, Society and Development 11, no. 17 (2022): e49111736735. http://dx.doi.org/10.33448/rsd-v11i17.36735.

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Researches show that individuals with Autistic Spectrum Disorder (ASD), present an imbalance in the intestinal microbiota, by the study carried out, there is a possibility of mitigating the characteristic symptoms of Autistic Spectrum Disorder, through the symbiosis in the intestinal microbiome. The objective of this bibliographic review is to analyze the influence of symbiosis on the microbiome in the intestine-brain axis in individuals with ASD and to verify the nutritional needs of this individual, in order to support nutritional strategies. Analyzing the gut-brain axis of children with ASD

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Tunesi, Marta, Luca Izzo, Ilaria Raimondi, Diego Albani, and Carmen Giordano. "A miniaturized hydrogel-based in vitro model for dynamic culturing of human cells overexpressing beta-amyloid precursor protein." Journal of Tissue Engineering 11 (January 2020): 204173142094563. http://dx.doi.org/10.1177/2041731420945633.

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Recent findings have highlighted an interconnection between intestinal microbiota and the brain, referred to as microbiota–gut–brain axis, and suggested that alterations in microbiota composition might affect brain functioning, also in Alzheimer’s disease. To investigate microbiota–gut–brain axis biochemical pathways, in this work we developed an innovative device to be used as modular unit in an engineered multi-organ-on-a-chip platform recapitulating in vitro the main players of the microbiota–gut–brain axis, and an innovative three-dimensional model of brain cells based on collagen/hyaluron

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OPREA, Georgiana, Madalina GHIDERSA, Ioana-Miruna BALMUS, et al. "Methodological Aspects Regarding the Interactions Between Microflora and Neuropsychiatric/Metabolic Disorders." Annals of the Academy of Romanian Scientists Series on Biological Sciences 12, no. 1 (2023): 82–94. http://dx.doi.org/10.56082/annalsarscibio.2023.1.82.

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"Considering that intestinal microbiota a key factor in regulating the brain- intestinal axis and is also involved in the development and proper functioning of the hypothalamic-pituitary-adrenal axis, numerous studies have turned their attention to the composition of digestive microflora in most of the neuropschiatric disorders. Same goes for the metabolic deficits, which could be correlated with some microbiome dysfucntions, as well as with most of the existent neuropschiatric deficiences. In this context, considering also our group recent experience in this area of research, we are describin

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Carter, Jasmine, Jeffery Bettag, Sylvia Morfin, et al. "Gut Microbiota Modulation of Short Bowel Syndrome and the Gut–Brain Axis." Nutrients 15, no. 11 (2023): 2581. http://dx.doi.org/10.3390/nu15112581.

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Short bowel syndrome (SBS) is a condition that results from a reduction in the length of the intestine or its functional capacity. SBS patients can have significant side effects and complications, the etiology of which remains ill-defined. Thus, facilitating intestinal adaptation in SBS remains a major research focus. Emerging data supports the role of the gut microbiome in modulating disease progression. There has been ongoing debate on defining a “healthy” gut microbiome, which has led to many studies analyzing the bacterial composition and shifts that occur in gastrointestinal disease state

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