Relevant bibliographies by topics / Intervertebral disc

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
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Academic literature on the topic 'Intervertebral disc'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 August 2024

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Journal articles on the topic "Intervertebral disc"

1

Noerma Kurniawa, Ceccare, Yeni Cahyati, and Rizki Agung Basuki. "PERBANDINGAN POSISI KNEE JOINT FLEKSI DAN EXTENSI PEMERIKSAAN LUMBOSACRAL ANTERO POSTERIOR (AP) SUPINE DALAM MEMPERLIHATKAN DISCUS INTERVERTEBRALIS." JRI (Jurnal Radiografer Indonesia) 3, no. 1 (June 11, 2021): 13–19. http://dx.doi.org/10.55451/jri.v3i1.55.

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Background : Supine examination of lumbosacral antero posterior projection (AP) is used to obtain a clear lumbosacral radiograph, one of which shows an intervertebral disc. The objective the research was to determine the knee joint flexion position and knee joint extension position on the antero posterior lumbosacral (AP) Supine examination in the appearance of intervertebral discs. Methods : Research of the position of the knee joint flexion and extension on the lumbosacral antero posterior (AP) Supine examination in displaying intervertebral discs, this is a comparative descriptive study, the researchers compared the position of the knee joint flexion and extension on Supine's lumbosacral antero posterior (AP) examination in showing the intervertebral disc so that it can be seen which position is better in performing Supine antero posterior (AP) lumbosacral radiographic examination in showing the intervertebral disc and which radiograph results. the best in establishing the diagnosis Result : From the research data in showing the knee joint flexion and extension position, the mean value of the joint gap on Supine's lumbosacral (AP) examination in showing L-1 intervertebral disc in the knee joint flexion position was 8.8 mm while the knee joint extension position was 8.8 mm. 7 mm intervertebral disc L-2, knee joint flexion is 10.2 mm, while knee joint extension is 9.2 mm, intervertebral disc L-3, knee joint flexion is 9 mm, while knee joint extension is 7.8 mm , intervertebral disc L-4 knee joint flexion position is 11 mm while knee joint extension is 9.8 mm, lumbal sacrum joint knee joint flexion is 9 mm while knee joint extension is 6.6 mm. Conclusion : The position of the knee joint flexion on the lumbosacral antero posterior (AP) examination Supine is better at showing the anatomical structure of the vertebral bodies, intervertebral discs, intervertebral foramen L1-L4, spinous processes, sacrum, and intervertebral disc joint gaps, intervertebral disc. The position of the knee joint extension on the examination of the lumbosacral antero posterior (AP) Supine can reveal the anatomical structures of the vertebral bodies, intervertebral discs, intervertebral foramen L1-L4, spinous processes, sacrum, but in revealing intervertebral disc joints, Intervertebral disc.
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Chabarova, Olga, Jelena Selivonec, and Alicia Menendez Hurtado. "Investigation of the Role of Osteoporotic Vertebra Degeneration on the Stability of the Lumbar Spine: In Silico Modelling under Compressive Loading." Bioengineering 11, no. 5 (May 17, 2024): 507. http://dx.doi.org/10.3390/bioengineering11050507.

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An evaluation of the impact of osteoporosis on loss of spinal stability, with or without intervertebral disc degeneration, using computational analysis is presented. The research also investigates the correlation between osteoporosis and intervertebral disc degeneration. Three-dimensional finite element models of human lumbar spine segments were used to assess the influence of osteoporosis on spinal stability. Five different models of age-related degeneration were created using various material properties for trabecular bone and intervertebral discs. Calculation results indicate that in a spine with osteoporosis, the deformation of the intervertebral discs can increase by more than 30% when compared to a healthy spine. Thus, intervertebral disc deformation depends not only on the degree of degeneration of the discs themselves, but their deformation is also influenced by the degree of osteoporosis of the vertebrae. Additionally, the load-bearing capacity of the spine can decrease by up to 30% with osteoporosis, regardless of the degree of intervertebral disc deformation. In conclusion, osteoporosis can contribute to intervertebral disc degeneration.
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Calleja-Agius, J., Y. Muscat-Baron, and M. P. Brincat. "Estrogens and the intervertebral disc." Menopause International 15, no. 3 (August 31, 2009): 127–30. http://dx.doi.org/10.1258/mi.2009.009016.

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Intervertebral discs are an integral part of the vertebral column. It has been shown that menopause has a negative effect on bone and on intervertebral discs. Estrogen has a beneficial effect of preserving the health of collagen-containing tissues, including the intervertebral disc. The intervertebral disc allows for mobility of the spine, and maintains a uniform stress distribution of the area of the vertebral endplates. Also, the disc influences spinal height. The disc tissue is adapted for this biomechanical function. The function of the spine is impaired if there is a loss of disc tissue. Narrowing of the disc space due to degeneration of intervertebral discs is associated with a significantly increased risk of vertebral fractures. Estrogen should be seen as the first-choice therapy for bones and other collagen-rich tissues, such as intervertebral discs, because it maintains homeostasis of the bone-remodelling unit. Unlike bisphosphonates, estrogen is unique in its ability to regenerate bone collagen after its disintegration, apart from suppressing osteoclastic activity. Besides, there is insufficient data on deterioration in bone qualities and micro-cracks in patients on long-term bisphosphonates.
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Fernandez-Moure, Joseph, Caitlyn A. Moore, Keemberly Kim, Azim Karim, Kevin Smith, Zonia Barbosa, Jeffrey Van Eps, Pranela Rameshwar, and Bradley Weiner. "Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy." SAGE Open Medicine 6 (January 1, 2018): 205031211876167. http://dx.doi.org/10.1177/2050312118761674.

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Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity. Degeneration of the disc can be a normal process of ageing, but can also be precipitated by other factors. Literature has made substantial progress in understanding the biological basis of intervertebral disc, which is reviewed here. Current medical and surgical management strategies have shortcomings that do not lend promise to be effective solutions in the coming years. With advances in understanding the cell biology and characteristics of the intervertebral disc at the molecular and cellular level that have been made, alternative strategies for addressing disc pathology can be discovered. A brief overview of the anatomic, cellular, and molecular structure of the intervertebral disc is provided as well as cellular and molecular pathophysiology surrounding intervertebral disc degeneration. Potential therapeutic strategies involving stem cell, protein, and genetic therapy for intervertebral disc degeneration are further discussed.
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5

Shu, Cindy C., Susan M. Smith, Christopher B. Little, and James Melrose. "Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc." Biochemical Journal 476, no. 2 (January 18, 2019): 225–43. http://dx.doi.org/10.1042/bcj20180695.

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Abstract Heparan sulfate (HS) regulates diverse cell signalling events in intervertebral disc development and homeostasis. The aim of the present study was to investigate the effect of ablation of perlecan HS/CS on murine intervertebral disc development. Genetic models carrying mutations in genes encoding HS biosynthetic enzymes have identified multiple roles for HS in tissue homeostasis. In the present study, we utilised an Hspg2 exon 3 null HS/CS-deficient mouse to assess the role of perlecan HS in disc cell regulation. HS makes many important contributions to growth factor sequestration, stabilisation/delivery, and activation of receptors directing cellular proliferation, differentiation, and assembly of extracellular matrix. Perlecan HS/CS-mediated interactions promote extracellular matrix assembly/stabilisation and tissue functional properties, and thus, removal of perlecan HS/CS should affect extracellular matrix function and homeostasis. Hspg2 exon 3 null intervertebral discs accumulated significantly greater glycosaminoglycan in the nucleus pulposus, annulus fibrosus, and vertebral growth plates than C57BL/6 wild-type (WT) I intervertebral discs. Proliferation of intervertebral disc progenitor cells was significantly higher in Hspg2 exon 3 null intervertebral discs, and these cells became hypertrophic by 12 weeks of age and were prominent in the vertebral growth plates but had a disorganised organisation. C57BL/6 WT vertebral growth plates contained regular columnar growth plate chondrocytes. Exostosis-like, ectopic bone formation occurred in Hspg2 exon 3 null intervertebral discs, and differences were evident in disc cell maturation and in matrix deposition in this genotype, indicating that perlecan HS/CS chains had cell and matrix interactive properties which repressively maintained tissue homeostasis in the adult intervertebral disc.
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Alberts, Russell, Arun-Angelo Patil, and Dongxue Zhou. "Single-unit artificial intervertebral disc." Journal of Neurosurgery: Spine 1, no. 1 (July 2004): 95–100. http://dx.doi.org/10.3171/spi.2004.1.1.0095.

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Object. The authors describe a new type of artificial disc called a single-unit artificial disc (SUAD). It is a single-unit disc without components, and there is no fixation system with which to maintain it in the disc space. It is theorized that its shape, hardness, and surface consistency, together with the compressive force exerted by the body's axial load, should be adequate to maintain the position of the disc in the disc space. In this paper the authors present their results of the kinematic tests in which the stability and integrity of the SUADs was tested. Methods. Panorobot was used for kinematic test fixture for fatigue testing for different types of SUAD. The test was performed after placing the disc between the C-5 and C-6 vertebral bodies (VBs) obtained from a cadaver. Eight pounds of weight was placed on the top of the container housing the C-5 VB to account for the weight of the head. The robot performed the following movements: 1) flexion—extension, 4.7° each; 2) lateral left—right bending, ± 2.1°; and 3) coupled rotation, ± 3.8°. Two flat discs (FDs) of 85 durometer (D), four 30D FD, two recess-edged discs (REDs) of 85D, and four custom-designed discs (CDDs) (custom molded to the disc space) of 30D were tested. None of the discs showed cracks or breakage at the end of the study. After 1 million cycles of excursions all 85D and 30D FD, and both 85D REDs showed weight loss. The 30D CDDs showed minimal weight gain at 1 million cycles. One of the CDDs, tested up to 5 million cycles, did lose weight at 5 million cycles. One 85D FD was extruded after 0.2 million cycles and one 85D RED rotated within the disc space. All other discs maintained their position in the disc space. Dimensional changes were minimal. Scanning electron microscopy of particles collected from one 30D CDD sample after 1 million cycles showed rough irregular granular particles 1 to 600 µm in diameter. Conclusions. These findings show that a 30D SUAD can maintain its position in the disc space without any anchoring device. Furthermore, at 1 million cycles of testing of 30 D SUAD, FDs did as well as the CDDs. This may be because softer discs mold to changes in dimension of the disc space. In addition the softer discs tend to wear less than the harder ones. Further fatigue study of 10 million cycles is needed to determine long-term efficacy, and the effects of wear on particles surrounding the joints need to be studied.
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Pauza, Kevin. "Cadaveric Intervertebral Disc Temperature Mapping During Disc Biacuplasty." October 2008 5;11, no. 10;5 (October 14, 2008): 669–76. http://dx.doi.org/10.36076/ppj.2008/11/669.

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Background: Disc Biacuplasty is a procedure for treating discogenic pain through neuron ablation by heating intervertebral disc tissue using cooled, bipolar radiofrequency (RF) technology. This study demonstrates temperature profiles created by disc biacuplasty in human cadavers. Objective: To assess temperature profiles created by disc biacuplasty in human cadaver discs. Design: The design of the experiment is a cadaver study with temperature monitoring in the intervertebral disc during disc biacuplasty. Method: Seven human cadaver discs were sectioned from 2 cadavers. Each disc was instrumented with 11 temperature sensors and 2 cooled radiofrequency probes. Correct placement was verified with the aid of fluoroscopy. The discs were then immersed in a 37°C thermostatic water bath and the treatment protocol was applied. Temperatures were monitored as the discs were heated. Results: At 13 minutes, with the settings used in this study, the posterior longitudinal ligament (PLL) temperature reached 40±3°C. The anterior disc reached 41±3°C. The outer layer of the posterior annulus fibrosus was heated to 54±6°C and the inner two-thirds of the posterior annulus fibrosus reached temperatures of 60±6°C. Conclusions: The anterior disc and PLL remained at safe temperatures below 45°C while temperatures throughout the center posterior and posterolateral disc were all raised above 45°C, sufficient for neural ablation. Key words: denervation, intervertebral disc, discogenic pain, radiofrequency ablation, transdiscal, disc biacuplasty
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Ylinen, P., R. M. Tulamo, M. Kellomäki, P. Türmälä, P. Rokkanen, and T. Palmgren. "Lumbar intervertebral disc replacement using bioabsorbable self-reinforced poly-L-lactide full-threaded screws, or cylindrical implants of polylactide polymers, bioactive glass and Polyactive™." Veterinary and Comparative Orthopaedics and Traumatology 16, no. 03 (July 2003): 138–44. http://dx.doi.org/10.1055/s-0038-1632777.

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SummaryIntervertebral disc surgery leads to changes in the segmental anatomy and mobility, and subsequently to degenerative changes in the lumbar spine. Artificial intervertebral disc implants sufficient to replace the human lumbar intervertebral disc have been developed and the requirements for these defined. This is to our knowledge the first study on bioabsorbable intervertebral disc replacement implants. SR-PLLA screws, previously used in orthopaedic internal fixations, and cylindrical implants, specifially developed for this experimental preliminary study, were used to replace lumbar intervertebral discs of growing pigs. After a 15-week follow-up period, the radiological and histological changes in the intervertebral spaces were analyzed. The cylindrical implants were able to prevent narrowing of discectomied spaces, and tissue regeneration in the intervertebral space was induced and occured simultaneously with degradation of the implant.
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Zhou, Zhiyu, Manman Gao, Fuxin Wei, Jiabi Liang, Wenbin Deng, Xuejun Dai, Guangqian Zhou, and Xuenong Zou. "Shock Absorbing Function Study on Denucleated Intervertebral Disc with or without Hydrogel Injection through Static and Dynamic Biomechanical Tests In Vitro." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/461724.

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Hydrogel injection has been recently proposed as a novel therapy for disc degenerative diseases, with the potential to restore the spine motion and the intervertebral disc height. However, it remains unknown whether the new technique could also maintain the shock absorbing property of the treated intervertebral disc. In this study, 18 porcine lumbar bone-disc-bone specimens were collected and randomly divided into three groups: the normal with intact intervertebral discs, the mimic for the injection of disulfide cross-linked hyaluronan hydrogels following discectomy, and the control disc with discectomy only. In the static compression test, specimens in the mimic group exhibited displacements similar to those in the normal discs, whereas the control group showed a significantly larger displacement range in the first two steps (P<0.05). With the frequency increasing, all specimens generally displayed an increasing storage modulus, decreasing loss modulus, and tanδ. At any frequency point, the control group exhibited the largest value in all the three parameters among three groups while the normal group was the lowest, with the mimic group being mostly close to the normal group. Therefore, the hydrogel injection into the intervertebral discs greatly restored their shock absorbing function, suggesting that the technique could serve as an effective approach to maintaining biomechanical properties of the degenerative intervertebral disc.
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Danylevych, V. P. "The lumbar intervertebral discs in males and females: measures, correlation, modeling." Reports of Vinnytsia National Medical University 26, no. 1 (March 28, 2022): 17–26. http://dx.doi.org/10.31393/reports-vnmedical-2022-26(1)-03.

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Annotation. The use of math algorithms for calculating the anatomical and functional parameters of the organs and systems based on somatometric parameters and allows to individualize and quantify the indicators of the norm. In order to build mathematical models to calculate the size of the lumbar spine intervertebral discs somatometry of almost healthy 80 girls and women aged 16-26 years and 74 juniors and men aged 17-28 years was performed. As well as magnetic resonance imaging of the lumbar spine was used to obtain the MR-images in the axial, sagittal and frontal planes in the T2-TSE mode and to perform MR-morphometry by using the DICOM image processing program. The correlation analysis and estimation of interrelations of somatometric parameters with partial linear sizes of intervertebral disks, the sum of the disks’ sizes and relative somato-disk rate are carried out. Body weight was found to have strong correlations with relative somato-disc rate (mean correlation coefficients for L1-L5 intervertebral discs were 0.803 and 0.821 in women and men, respectively) and weak and very weak correlations with partial disc sizes. When constructing the regression model, as an intermediate stage of the calculation, the somato-disk rate (the ratio of mass-growth coefficient to the sum of the sizes of the intervertebral disc) was used. The simulation of the three sizes’ sum of intervertebral discs L1-L5 segments was ultimately based on weight and body length (coefficient of determination R2 is from 80.4% for the sum of the intervertebral discs L1-L2 in girls and women and boys and men, up to 89.7% for the sum of the size of the intervertebral disc L4-L5 in girls and women). Verification of the obtained mathematical models showed a discrepancy between the calculated and measured indicators of the sums of intervertebral disc sizes in the presence of disc degeneration. The used mathematical algorithm for calculating individualized indicators of linear dimensions of lumbar intervertebral discs on the base of somatometric parameters allowed to determine the absence of objective quantitative changes in unchanged intervertebral discs and avoid overdiagnosis.
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Dissertations / Theses on the topic "Intervertebral disc"

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Stefanakis, Manos. "Biomechanics of intervertebral disc pain." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556723.

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'Background: Back pain is strongly (but variably) associated with degeneration of intervertebral discs. Mechanical loading has long been considered one of the causes of disc pathology and pain, but its precise role is poorly understood. In particular the spatial relation between load distribution inside the disc, the disc matrix changes as a result of load and their relationship with pain has not been researched. Methods: Distribution of compressive stress inside intervertebral discs from all regions of the spine was studied using stress profilometry in cadaveric motion segments. Matrix pathological changes were studied using simple histology and light microscopy in two groups of surgically removed discs: 'painful' discs from patients undergoing surgery for suspected discogenic pain, and 'control' discs from patients undergoing surgery for scoliosis or spondylolisthesis reduction. Ingrowth of nerves and blood vessels into the annulus was studied by immunohistochemistry with an endothelial and a general neuronal marker. Stress reduction inside annulus fissures were investigated using stress profilometry. Proteoglycan reduction within annulus fissures was studied by means of a novel, semi-quantitative method involving simple histology and image analysis. Although semi-quantitative, the technique had great spatial resolution and allowed integration with the results from the mechanical experiments. Results: High stress concentrations were localised in the middle annulus and increased with disc degeneration. Associated stress gradients appeared early in the degeneration process and were not diminished in late stage degeneration when substantial compressive loading is transferred to the neural arch. Nerve and blood vessel ingrowth increased with degeneration, but were confined to the outermost 4mm of the annulus. Other cellular changes such as apoptosis, cellular infiltration and proliferation were mostly confined to the annulus. Annulus fissures were found to represent focal regions of low proteoglycan content, and also of low compressive stress, especially when the nucleus was also decompressed. Conclusions: Results suggest that high stress gradients play an important role in progressive annulus disruption, and that annulus fissures provide a microenvironment that is mechanically and chemically conducive to the ingrowth of nerves and blood vessels. Co-localisation of nerves, blood vessels and stress concentrations in the middle-outer annulus suggest that this is the most likely site of discogenic pain. Pain is associated with annulus disruption and the attempted healing rather than age-related degenerative changes in the nucleus.
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Lemos, Felipe Fernandes [UNESP]. "Influência da desidratação no comportamento mecânico do disco intervertebral lombar." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/105330.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
A desidratação do núcleo pulposo que, juntamente com o anulus fibroso, compõe o disco intervertebral, participa do processo de degeneração da coluna vertebral. Torna-se importante entender como este processo de desidratação e a consequente alteração das propriedades mecânicas influenciam na biomecânica dessa articulação. O principal objetivo deste estudo é analisar a influência da desidratação no coeficiente de amortecimento viscoso e como esta variação pode alterar o comportamento mecânico do disco intervertebral lombar. Este estudo é composto de duas etapas: na primeira, o coeficiente de amortecimento viscoso foi obtido experimentalmente de unidades funcionais de colunas lombares suínas antes e após o processo de desidratação das mesmas; na segunda, foi simulado em modelo computacional a resposta harmônica, utilizando-se dados da literatura e do coeficiente de amortecimento viscoso, analisando as diferenças entre uma simulação com o disco intervertebral hidratado e desidratado. O coeficiente de amortecimento viscoso hidratado (4,7) e desidratado (2,7) apresentou diferença estatisticamente significante (p<0,001). Na simulação computacional podese evidenciar uma menor influência da variação do coeficiente de amortecimento viscoso quando analisado de forma isolada do que quando analisado em conjunto com variações nos dados referentes à rigidez, principalmente nas frequências de ressonância e nas amplitudes de pressão intradiscal e deformação do disco intervertebral. Concluiu-se que discos intervertebrais desidratados respondem de forma diferente à vibração, o que pode contribuir para os processos lesivos da coluna vertebral
The dehydration of the nucleus pulposus which, with the anulus fibrosus, composes the intervertebral disc, participates in the process of degeneration of the spine. It is important to understand how this process and the consequent alteration of dehydration of the mechanical properties influence the biomechanics of this joint. The aim of this study is to analyze the influence of dehydration in the viscous damping coefficient and how this variation can change the mechanical behavior of lumbar intervertebral disc. This study consists of two stages: first, the viscous damping coefficient was obtained experimentally in functional units of porcine lumbar spine before and after the dehydration process of them; second, an harmonic response was simulated in a computer model, using literature data and the viscous damping coefficient, analyzing the differences between a simulation with the hydrated and dehydrated intervertebral disc. The hydrated (4.7) and dehydrated (2.7) viscous damping coefficient showed a statistically significant difference (p <0.001). In the computer simulation, a lower influence of variation of the viscous damping coefficient can be detected when analyzed separately than when analyzed together with variation on stiffness data, especially in the resonance frequencies and in the amplitudes of the intradiscal pressure and deformation of the intervertebral disc. We conclude that dehydrated intervertebral discs respond differently to vibration, what can contribute to the damaging processes of the spine
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González, Guitiérrez Ramiro Arturo. "Biomechanical study of intervertebral disc degeneration." Doctoral thesis, Universitat Politècnica de Catalunya, 2012. http://hdl.handle.net/10803/76781.

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Degeneration and age affect the biomechanics of the intervertebral disc, by reducing its stiffness, flexibility and shock absorption capacities against daily movement and spinal load. The biomechanical characterization of intervertebral discs is achieved by conducting mechanical testing to vertebra-disc-vertebra segments and applying axial, shear, bend and torsion loads, statically or dynamically, with load magnitudes corresponding to the physiological range. However, traditional testing does not give a view of the load and deformation states of the disc components: nucleus pulposus, annulus fibrosus and endplate. Thus, the internal state of stress and strains of the disc can only be predicted by numerical methods, one of which is the finite element method. The objective of this thesis was, to study the biomechanics of degenerated intervertebral discs to load conditions in compression, bending and torsion, by using mechanical testing and a finite element model of disc degeneration, based on magnetic resonance imaging (MRI). Therefore, lumbar discs obtained from cadavers corresponding to spinal levels L2-L3 and L4-L5 with mild to severe degeneration were used. Intervertebral osteochondrosis and spondylosis deformans were identified, being the disc space collapse, the most striking feature. Next, all discs were tested to static and dynamic load conditions, the results gained corresponded to the disc stiffness (in compression, bending and torsion), stress relaxation and dynamic response. Of these, the stiffness response was used to validate the disc model. The testing results suggest that discs with advanced degeneration over discs with mild degeneration are, less rigid in compression, less stiffer under bending and torsion, showed less radial bulge, and reduce their viscoelastic and damping properties. This study shows that degeneration has an impact on the disc biomechanical properties which can jeopardize normal functionality. Development of one finite element model of disc degeneration started by choosing a MRI of a L2-L3 disc. Segmentation of vertebra bone and disc materials followed, and were based on pixel brightness and radiology fundamentals, then a finite element mesh was created to account for the disc irregular shape. The disc materials were modeled as hyperelastic and the bone materials were modeled as orthotropic and isotropic. Adjustment of material properties was based on integrity of the annulus fibrosus, giving a stiffness value matching that of a mild degeneration disc. Then, validation of the model was performed, and included a study of the distributions of stress and strain under loads of compression, bending and torsion. The results from all load simulations show that the disc undergoes large deformations. In contrast, the vertebrae are subjected to higher stress but with negligible deformations. In compression, the model predicted formation of symmetrical disc bulge which agree with the testing behavior. The nucleus pulposus showed to be the principal load carrier with negative principal stresses and strains. In bending and torsion, the annulus fibrosus showed to be the principal load carrier with large symmetrical principal strains and stresses for the former loading and large shearing for the latter. The study showed the importance of soft tissue deformation, mostly noticed in advanced degeneration. In contrast, the higher stresses in the vertebra over those of the intervertebral disc showed the relevance of bone predisposition to fracture. Such kind of studies, should contribute to the understanding of the biomechanics of the intervertebral disc.
La degeneración y edad afectan la biomecánica del disco intervertebral, reduciendo la capacidad de rigidez, flexibilidad y atenuación de impactos, contra el movimiento y carga del raquis. La caracterización biomecánica del disco se realiza con ensayos mecánicos a segmentos de vértebra-disco-vértebra y aplicando cargas axiales, cortantes, flexión y torsión, estáticas ó dinámicas, con magnitudes de carga según el intervalo fisiológico. Sin embargo, las pruebas tradicionales no dan una visión de los estados de carga y deformación de los componentes del disco: núcleo pulposo, anillo fibroso y placa terminal. Por lo tanto, el estado interno de esfuerzos y deformaciones del disco, solo puede ser predicho con métodos numéricos, uno de los cuales es el método de elemento finito. El objetivo de esta tesis fue, estudiar la biomecánica de discos intervertebrales degenerados a las condiciones de carga en compresión, flexión y torsión, mediante el uso de ensayos mecánicos y de un modelo de elementos finitos de la degeneración de disco, basado en imágenes con resonancia magnética (MRI). Por lo tanto, se usaron discos lumbares L2-L3 y L4-L5 obtenidos de cadáveres, con degeneración leve a severa. Se identificó osteocondrosis intervertebral y espondilosis deformante, siendo el colapso del espacio intervertebral el aspecto más relevante. Luego, todos los discos fueron ensayados a condiciones de carga estática y dinámica, y los resultados correspondieron a la rigidez del disco (a compresión, flexión y torsión), a la relajación de tensiones y a la respuesta dinámica. De éstos, la rigidez fue usada para validar el modelo de disco. Los resultados de los ensayos sugieren que los discos con degeneración avanzada sobre aquellos con degeneración leve son, menos rigidos a compresión, menos rigidos a flexión y torsión, presentan menor protuberancia radial, y reducen sus propiedades viscoelásticas y de amortiguamiento. El estudio muestra que la degeneración impacta las propiedades biomecánicas del disco, poniendo en riesgo la funcionalidad normal. El desarollo de un modelo de elementos finitos de la degeneración de disco inició eligiendo una secuencia de resonancia magnética de un disco L2-L3. La segmentación de los materiales del disco y de las vértebras se realizó basado en intensidad de brillo del pixel y en fundamentos de radiología, y se creó una malla de elementos finitos correspondiente a la forma irregular del disco. Los materiales del disco se modelaron como hiperelásticos y los tejidos óseos se modelaron como materiales ortotrópicos e isotrópicos. El ajuste de propiedades de los materiales fue basado en la integridad del anillo fibroso, y dio una rigidez correspondiente a la de un disco con degeneración leve. Luego, se realizó la validación del modelo, e incluyó un estudio de las distribuciones de esfuerzo y deformación a las condiciones de carga en compresión, flexión y torsión. Los resultados de todas las simulaciones de carga mostraron que el disco es sometido a grandes deformaciones. En contraste, las vértebras fueron sometidas a mayores esfuerzos pero con deformaciones insignificantes. En compresión, el modelo predijo la formación de una protuberancia radial simétrica, en concordancia con la experimentación. El núcleo pulposo mostró ser el portador principal de carga, con tensiones y deformaciones principales negativas. En flexión y torsión, el anillo fibroso mostró ser el portador principal de carga, con grandes deformaciones y tensiones principales simétricas para la primera carga, y con grandes tensiones cortantes para la segunda carga. El estudio mostró la importancia de las deformaciones de los tejidos blandos, principalmente notados en la degeneración avanzada. Por el contrario, las tensiones mayores en los cuerpos vertebrales sobre aquellas del disco intervertebral mostraron la relevancia de la predisposición a las fracturas óseas. Este tipo de estudio debe contribuir a la comprensión de la biomecánica del disco intervertebral.
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Osti, Orso L. "Annular tears and intervertebral disc degeneration /." Title page, contents and abstract only, 1990. http://web4.library.adelaide.edu.au/theses/09PH/09pho85.pdf.

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Liu, Jane J. "Proteoglycans of the human intervertebral disc." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68204.

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The composition and heterogeneity of human intervertebral disc proteoglycans from different aged individuals were investigated. (1) The glycosaminoglycan content in the nucleus pulposus was greater than that in the annulus fibrosus at all ages. Glycosaminoglycan content increased from the infant to the young adult, and then decreased from the young to the mature adult. (2) Disc contained a higher content of hyaluronate than articular cartilage at all ages. (3) Proteolytically modified LP3 was predominant in the disc. (4) Very low link protein concentrations were observed in adult disc proteoglycan preparations and adult disc extracts analysed by SDS/PAGE and immunoblotting suggesting a deficiency in link protein content. In contrast, radioimmunoassay of disc extracts suggests no deficiency in link protein content. (5) The existence of extremely fragmented link protein in adult disc is postulated to reconcile the results of the two analytic methods. (6) Non-proteoglycan forms of biglycan and decorin are present in the disc. The difference between the two non-proteoglycan forms of biglycan appears to be due to different N-linked oligosaccharide substitution rather than proteolysis.
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Naish, Claudia Martha. "Ultrasound imaging of the intervertebral disc." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288301.

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Molinari, Michael B. "Mechanical fractionation of the intervertebral disc." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:7385c54f-a3d0-4467-aca4-c7a9b8686982.

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Chronic lower back pain is a major public health problem, with direct and indirect economic costs comparable to those of heart disease, depression and diabetes. In many cases this pain derives from degeneration of the intervertebral disc (IVD), a fibrous, avascular tissue that sits between the vertebrae in the spinal column. A novel treatment approach for this ‘discogenic’ pain is the injection of a hydrogel that hybridises in situ and restores the normal biomechanical function of the disc. While a number of promising materials are currently under development, existing approaches to removing degenerate material from the disc prior to injection are invasive and compromise the structural integrity of the disc. Mechanical fractionation of the tissue using acoustic cavitation generated by high intensity focussed ultrasound (HIFU) has the potential to be non-invasive, and to enhance the effectiveness of the procedure by preserving the outer regions of the disc. The primary goal of this thesis is to investigate the feasibility of this approach. The acoustic properties of the disc were first measured using a modified scanning acoustic microscope. The outer region of the disc, the annulus fibrosus (AF) was found to be highly attenuative compared to the central nucleus pulposus (NP). These measured properties were then used in a simplified two-dimensional model to simulate the shape of the acoustic pressure field within the disc. A configuration using two confocal spherically focussed 0.5 MHz single-element transducers was able to produce a tightly focused field suitable for use in the IVD. As preliminary experiments suggested that high pressure amplitudes were required to initiate cavitation inside the disc, the use of exogenous nuclei to lower this threshold was investigated. A novel class of solid sonosensitive nanoparticles (SNPs) suitable for use in the IVD were developed and characterised. These SNPs comprise a layer of hydrophobic silica particles deposited onto a polystyrene core, and are thought to trap small gas pockets in surface crevices. Coated particles were found to reduce the cavitation threshold significantly in both water and blood, from some 2.0 - 2.5 MPa at 1.067 MHz to below 1.0 MPa. The particles were also found to provide repeatable initiation of cavitation activity during prolonged or repeated exposures, and to exhibit good storage stability, suggesting that they they may be appropriate for use within the IVD. Finally, a combined therapy and monitoring system was designed, built and validated. The system comprised two confocal 0.5 MHz spherically focussed HIFU transducers with central openings, each co-axially aligned with either a single element passive cavitation detector or a 64-element array that could be used for both active and passive imaging. The system was found to be capable of initiating inertial cavitation in the disc at pressures as low as 2.5MPa in the presence of sonosensitive nanoparticles. Use of the array in active mode enables creation of a B-mode image that provides anatomical information on the boundaries of the IVD, whist the same array could be used for passive mapping of acoustic emissions arising fromthe HIFU focus during therapy. Two different exposure regimes were found to be capable of producing sizeable perforations within the NP without significantly damaging the AF, and preliminary investigations were carried out into themechanism of damage. The location and extent of cavitation as seen on passive maps acquired during treatment was found to coincide with the regions of NP fractionation. This confirms that passive acoustic mapping can provide the real-time treatment monitoring necessary to ensure both safety and efficacy of ultrasonic IVD fractionation. Prior to clinical application, a significant amount of further development is required to further validate non-invasive disc fractionation by HIFU and the subsequent steps for minimally invasive disc replacement using injectable hydrogels. The present work has nonetheless demonstrated for the first time that minimally invasive removal of degenerate disc tissue is feasible trough the combined use of sonosensitive nanoparticles and a relatively low-cost therapeutic ultrasound system that provides simultaneous anatomical imaging and real-time treatment monitoring by passive acoustic mapping.
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Luxmoore, Bethany Jane. "Computational simulation of the intervertebral disc." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/4685/.

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The intervertebral disc is a complex structure unlike any other in the human body. The capability to withstand high loads and deformations in six degrees of freedom is facilitated by the unique soft tissue structures. However, the mechanical behaviour of these tissues is not well understood. The aim of this project was to investigate methods of deriving structural information about the tissues of the intervertebral disc for application in computational simulation, with particular focus on the mechanical function of the annulus fibrosis and how the behaviour of this tissue is governed by its substructures. Magnetic resonance imaging techniques were assessed for potential to inform specimen specific models of the disc. Imaging sequences were developed and validated to image in vitro disc samples in unloaded and compressed states. These images captured the lamellar structure of the annulus in three dimensions to a level of detail not previously published. The image data facilitated the development of a novel method of specimen specific model construction, as well as providing experimental deformation data, against which the models were directly validated. Sensitivity analyses on both generalised and specimen specific models illustrated the influence of interlamellar interaction representation on the gross mechanics of the disc models. The models were adapted to illustrate the effects of tissue degeneration and intervention on disc mechanics Interlamellar interactions and tissue level mechanics were further investigated by developing specimen specific models of disc tissue samples based on microscopy data. Novel methods were developed to implement qualitative histological data into finite element analyses of annulus tissue samples. Interlamellar interactions were shown to provide a strong bond between lamellae. The parameters and variables involved in the mechanical system of the disc pose major challenges for experimental investigation. This study has successfully laid the ground work to negotiate these challenges using a computational approach
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Jim, Jin-to. "Genetics and molecular characterization of degenerative disc disease." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B35720189.

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Chan, Kit-ying, and 陳潔瑩. "Development of whole disc organ culture system and acellular disc scaffold for intervertebral disc engineering." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45600077.

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Books on the topic "Intervertebral disc"

1

Shapiro, Irving M., and Makarand V. Risbud, eds. The Intervertebral Disc. Vienna: Springer Vienna, 2014. http://dx.doi.org/10.1007/978-3-7091-1535-0.

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Thacher, Christopher. Intervertebral disc disease. Edited by Kay William J and Brown Nancy O. Philadelphia, PA: J.B. Lippincott, 1989.

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M, Phillips Frank, and Lauryssen Carl, eds. The lumbar intervertebral disc. New York, NY: Thieme Medical Publishers, 2010.

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4

Colville, Gordon Malcolm Herbert. Enzymes of the intervertebral disc. Manchester: University of Manchester, 1995.

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W, Hardy Russell, ed. Lumbar disc disease. 2nd ed. New York: Raven Press, 1993.

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1940-, Ghosh P., ed. The Biology of the intervertebral disc. Boca Raton, FL: CRC Press, 1988.

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Grad, Sibylle, Mauro Alini, David Eglin, Daisuke Sakai, Joji Mochida, Sunil Mahor, Estelle Collin, Biraja Dash, and Abhay Pandit. Cells and Biomaterials for Intervertebral Disc Regeneration. Cham: Springer International Publishing, 2010. http://dx.doi.org/10.1007/978-3-031-02580-8.

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Postacchini, Franco. Lumbar disc herniation. Wien: Springer, 1999.

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1915-, Brown Joseph E., Nordby Eugene J, and Smith Lyman, eds. Chemonucleolysis. Thorofare, NJ: Slack, 1985.

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G, Watkins Robert, and Collis John S, eds. Lumbar discectomy and laminectomy. Rockville, Md: Aspen Publishers, 1987.

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Book chapters on the topic "Intervertebral disc"

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Cortes, Daniel H., and Dawn M. Elliott. "The Intervertebral Disc: Overview of Disc Mechanics." In The Intervertebral Disc, 17–31. Vienna: Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1535-0_2.

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Lasanianos, Nick G., George K. Triantafyllopoulos, and Spiros G. Pneumaticos. "Intervertebral Disc Herniation." In Trauma and Orthopaedic Classifications, 243–45. London: Springer London, 2014. http://dx.doi.org/10.1007/978-1-4471-6572-9_54.

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Crock, Henry Vernon. "Intervertebral Disc Calcification." In A Short Practice of Spinal Surgery, 147–57. Vienna: Springer Vienna, 1993. http://dx.doi.org/10.1007/978-3-7091-6650-5_4.

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Adams, Michael A. "Intervertebral Disc Tissues." In Engineering Materials and Processes, 7–35. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03970-1_2.

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Eseonu, Kelechi, and Nicolas Beresford-Cleary. "Intervertebral Disc Anatomy." In Spine Surgery Vivas for the FRCS (Tr & Orth), 213–14. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003201304-59.

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Shah, Akansha M., Sarah Yoon Ji Kwon, Wilson C. W. Chan, and Danny Chan. "Intervertebral Disc Degeneration." In Cartilage, 229–61. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-45803-8_10.

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Lavignolle, B. "The Intervertebral Disc." In Spinal Anatomy, 207–16. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-20925-4_14.

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Brisson, Brigitte A. "Intervertebral Disc Fenestration." In Current Techniques in Canine and Feline Neurosurgery, 191–98. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781118711545.ch22.

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Shapiro, Irving M., and Makarand V. Risbud. "Introduction to the Structure, Function, and Comparative Anatomy of the Vertebrae and the Intervertebral Disc." In The Intervertebral Disc, 3–15. Vienna: Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1535-0_1.

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Yee, Anita, and Danny Chan. "Genetic Basis of Intervertebral Disc Degeneration." In The Intervertebral Disc, 157–76. Vienna: Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1535-0_10.

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Conference papers on the topic "Intervertebral disc"

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Maleskian, M., S. S. Park, and C. J. Hunter. "Experimental Modal Analysis of Intervertebral Disc Joint Dynamics." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-191699.

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The intervertebral discs provide mobility and a degree of shock absorbance to the spinal column. It has been shown that the mechanical properties of the intervertebral discs play an important role in their functionality [1, 2]. While static models of the intervertebral disc have significance, dynamic models characterize more accurately the in situ nature of the tissues. Some researchers [3] have studied dynamic disc loading from the perspective of biomedical performance and fatigue failure. Other studies have reported on the viscoelastic properties of discs under high frequency vibration [4]. However, the authors did not find any study which used experimental modal analysis (EMA) and the receptance coupling (RC) method to extract the dynamic characteristics, i.e. stiffness, damping, and natural frequencies, of the intervertebral discs.
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Hwang, David, Miao Yu, and Adam H. Hsieh. "Dependence of Intervertebral Disc Pressure Generation on Load History." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204233.

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It has been thoroughly documented that low back pain is often associated with deregulated biological function and compromised mechanical behavior of the intervertebral disc. Therefore, intervertebral disc mechanics have long been thought of as important factors both in driving cell-mediated processes involved in degeneration and in distinguishing between healthy versus degenerate discs. The nucleus pulposus is an integral part of the mechanics of the disc, the key property being its ability to pressurize to resist and distribute compressive stress to the annulus fibrosus and the endplates. There has been a history of intradiscal pressure measurements in cadaveric as well as large animal studies; however, these studies have focused on the consequences of degeneration or the change in stress distribution by varying spinal orientations. In order to be able to relate local stresses induced in discs to changes in cellular function, such pressure measurements must be obtained from an animal model amenable to chronic disc loading. Rat tail discs have been one widely used laboratory model, but the discs are too small for measuring load-induced nucleus pressures using current sensor technology.
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Kim, Jesse G., Tae-Hong Lim, Susan M. Renner, Atsushi Fujiwara, Cahn Nuyen, Taekhoon Yoon, and Howard S. An. "Experimental Intervertebral Disc Degeneration: Compressive Behavior Changes Over Time." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2611.

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Abstract Changes in axial compressive behavior of the intervertebral disc resulting from annulus stab wound were investigated using rabbit discs. Results of this study clearly showed that stabbing incision could cause disc degeneration with losses in disc height, elastic modulus, and energy dissipation capacity in 8 weeks after injury. Disc specimens obtained at 12 weeks after stab incision showed no further changes in disc height and axial compressive behavior from those found in 8 week specimens.
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Wiltsey, Craig, Thomas Christiani, Jesse Williams, Jamie Coulter, Dana Demiduke, Katelynn Toomer, Sherri English, et al. "Tissue Engineering of the Intervertebral Disc." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80349.

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Tissue engineering is a rapidly growing field of research that aims to repair damaged tissues within the body. Among tissue engineering approaches is the use of scaffolds to help regenerate lost tissues. Scaffolds provide structural support for specific areas within the body, namely load bearing regions, and allow for cells to be seeded within the scaffold for tissue regeneration. Scaffolds that specifically replicate the properties and/or composition of native tissues are referred to as biomimetic scaffolds.
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Lee, Cynthia R., Mauro Alini, and James C. Iatridis. "Organ Culture System for Mechanobiology Studies of the Intervertebral Disc." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61248.

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The development of in vitro models is critical for furthering understanding of the intervertebral disc and the development of disc regeneration/tissue engineering. An in vitro culture system targeted towards mechano-biology studies of the intervertebral disc (IVD) was built and validated using bovine coccygeal discs. Discs were maintained in culture for up to one week with and without vertebral endplates. Water content and glycosaminoglycan content were found to be stable and cells were metabolically active when cultured under a 5kg static load.
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Kumaresan, Srirangam, Frank A. Pintar, Narayan Yoganandan, Phaladone J. Khouphongsy, and Joseph F. Cusick. "Intervertebral Disc Morphology in Cervical Spine Biomechanics." In ASME 1999 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/imece1999-0464.

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Abstract Although qualitative descriptions of degenerative changes in the intervertebral disc components have been reported, methods to quantify these changes are lacking. A methodology was developed in this study to quantify the three-dimensional geometrical variations of the annulus fibrosus and nucleus pulposus. Fresh isolated intervertebral discs with adjacent vertebral bodies of skeletally mature young and old adult primates were sectioned sequentially, and different staining methods were used to distinguish the annulus and nucleus. Histological images were examined using light microscopy and exported to a computer to trace the boundaries of the annulus fibrosus and nucleus pulposus. Dorsal to ventral depth, medial to lateral width, and caudal to cranial height measurements of the nucleus pulposus and its relative location to the annulus pulposus were obtained. In the young adult, the nucleus was translucent with scattered notochordal cells. In the older adult, the nucleus appeared as a dense region of amorphous, irregular collagen material. A higher geometrical variation of nucleus due to degeneration was noted in the sagittal plane compared to coronal plane. Determination of the three-dimensional geometrical variations and histology analyses will assist mathematical modelers to better define the disc to study the biomechanics of the cervical spine.
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Colliou, Olivier K., Ellen Liebenberg, Neil A. Duncan, and Jeffrey C. Lotz. "Compression-Induced Intervertebral Disc Degeneration in a Mouse Model." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-0279.

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Abstract While the cause of low-back pain is unknown in many patients, a significant percentage is thought to be due to degeneration of the intervertebral disc1. Because of the severe structural demands placed on the spine, and the epidemiological association between physical activity and disc degeneration, mechanical forces are thought to be a central etiologic factor. Therefore, precise knowledge of the cascade of biologic events associated with disc degeneration, and the means by which they are coupled to physical loading, would be invaluable for developing improved guidelines for maintaining disc health and for directing tissue repair. The aim of this study was to develop an in vivo mouse model in which disc degeneration is induced through the application of a precisely controlled and quantified mechanical load.
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8

Natarajan, Raghu N., Mohammed Qasim, Howard An, and Gunnar B. J. Andersson. "Effect of Annular Micro Tear on Lumbar Intervertebral Disc Biomechanics." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19025.

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Structural alterations of the disc are accompanied by changes in disc tissue structure and composition during degeneration processes. Human cadaver studies have shown that the probability of presence of annular tear is 0.6 in the age group 30 to 34 which increases to 0.85 in the 60 year age group. Among different phenomena that occur during disc degeneration, annular radial tears are commonly associated with disc herniations. The effect of increase in size of radial micro tear in the lumbar discs on the change in biomechanics of the disc is an area where there is very little information currently in the literature.
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9

Marini, Giacomo, Gerd Huber, and Stephen J. Ferguson. "Nonlinear Dynamic Behaviour of the Intervertebral Disc." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14641.

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The intervertebral disc, like many collagen-based tissues, has a mechanical response which is highly nonlinear (1). This characteristic is due to both the arrangement and composition of the tissue constituents of the disc (2). Over the past decades several studies have reported the nonlinear response of the disc for different loading scenarios. In particular, past studies were focused on the quasi-static and low frequency (< 10Hz) response to pure and combined cyclic loading, such as axial compression, shear, flexion/extension moment (3–6). The information provided by these studies has been applied in several fields, from the validation of numerical models to the development of disc prostheses. However, such loading conditions are only partially representative of the in-situ load that the intervertebral disc normally experiences. High frequency dynamics stimuli, such as that experienced while driving a car on a rough surface or driving heavy industrial machinery, are also important. It is well known that long-term exposure to vibrational loading is detrimental to normal disc metabolism (7,8). Despite its relevance only a few studies have investigated the dynamic response of the disc to high frequency vibration (9,10) with sometimes different outcomes. In particular, no study has shown an asymmetric, nonlinear dynamic behavior of the system, even though it is evident in quasi-static testing — the well-known tension / compression asymmetry. This aspect is somehow neglected when building rigid body models of the upper body for impact simulation where a Kelvin-Voigt model with linear stiffness is normally used. The aim of this experimental study was therefore to investigate the nonlinear dynamic response of the intervertebral disc to high frequency loadings, taking different pre-loads and displacement amplitude into account.
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10

Terbetas, G., A. Kozlovskaja, D. Varanius, V. Graziene, J. Vaitkus, and A. Vaitkuviene. "Spectroscopic Parameters of Lumbar Intervertebral Disc Material." In LASER FLORENCE 2008: Selected Presentations at the International Laser Medicine Congress. American Institute of Physics, 2009. http://dx.doi.org/10.1063/1.3175623.

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Reports on the topic "Intervertebral disc"

1

Smith, Paul N., David R. J. Gill, Michael J. McAuliffe, Catherine McDougall, James D. Stoney, Christopher J. Vertullo, Christopher J. Wall, et al. Demographics of Spinal Disc Arthroplasty: Supplementary Report. Australian Orthopaedic Association, October 2023. http://dx.doi.org/10.25310/yjor3105.

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The 2023 Demographics of Spinal Disc Arthroplasty Supplementary Report is based on the analysis of 11,343 spinal disc procedures recorded by the Registry with a procedure date up to and including 31 December 2022. This supplementary report provides summary data and demographic information on spinal disc replacement surgery. Data are broken down into the five classes of spinal disc replacement: spinal segment, spinal ball trough, insert and endplate, cervical intervertebral disc and lumbar intervertebral disc. Revision rates are not provided for spinal disc replacement. The Spinal Disc Arthroplasty Report is one of 16 supplementary reports to complete the AOANJRR Annual Report for 2023. Information on the background, purpose, aims, benefits and governance of the Registry can be found in the Introductory chapter of the 2023 Hip, Knee and Shoulder Arthroplasty Annual Report. The Registry data quality processes including data collection, validation and outcome assessment, are provided in detail in the Data Quality chapter of the 2023 Hip, Knee and Shoulder Arthroplasty Annual Report: https://aoanjrr.sahmri.com/annual-reports-2023.
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2

Snyder, Brian. Development of Ultrasound to Measure In-vivo Dynamic Cervical Spine Intervertebral Disc Mechanics. Fort Belvoir, VA: Defense Technical Information Center, January 2014. http://dx.doi.org/10.21236/ada600493.

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3

Duan, Jiahao, Shaofeng Yang, Zhaoyong LI, Long Chen, and Ran Teng. Treatment of lumbar intervertebral disc herniation by invigorating kidney and promoting blood Circulation：A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0080.

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4

Guo, Tianci, Huichuan Feng, Aifeng Liu, Jixin Chen, and Weijie Yu. Efficacy and safety of percutaneous endoscopic lumbar discectomy via intervertebral approach for L5/S1 lumbar disc herniation: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2021. http://dx.doi.org/10.37766/inplasy2021.7.0073.

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5

Li, Wenhao, He Zhao, Zhencheng Xiong, Chuanhong Li, Jianbin Guan, Tao Liu, Yongdong Yang, and Xing Yu. Evaluation of the efficacy of stem cell therapy in animal models of intervertebral disc degeneration based on imaging indicators: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0148.

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6

Li, Jiaqi, PWH Kwong, MYL Chan, and M. Kawabata. Comparison of in vivo intradiscal pressure between sitting and standing in human lumbar spine: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0043.

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Review question / Objective: The primary objective of this systematic review is to compare the differences in vivo IDP between sitting and standing postures. The secondary objective of this review is to compare effect size estimates between 1) dated and more recent studies and 2) healthy and degenerated intervertebral discs. Condition being studied: Healthy adults, patients with low back pain. Eligibility criteria: Studies were included in the review if they 1) involved in vivo IDP measurement in both sitting and standing postures, 2) involved measurements with intervertebral body replacement and 3) included spinal loading data of healthy adults. Studies were excluded if they 1) investigated in vitro measurement of IDP, 2) did not report the central tendency and/or variability of the outcome of interest and 3) were letters to the editor, case studies, case series or review articles. For the relevant papers that did not provide sufficient data, we contacted the corresponding author to acquire the data.
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7

A GLP Chronic Study to Evaluate the Biological Effects and Systemic Toxicity of Rejuve (IDSD) Implantation in an Ovine Intervertebral Disc Model. Spinal Simplicity LLC, October 2018. http://dx.doi.org/10.57212/emyn8297.

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