Journal articles on the topic 'Intermittent mouth'

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1

Lobprise, Heidi B., and Robert B. Wiggs. "Modified Surgical Treatment of Intermittent Open-Mouth Mandibular Locking in a Cat." Journal of Veterinary Dentistry 9, no. 1 (March 1992): 8–12. http://dx.doi.org/10.1177/089875649200900102.

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Intermittent open-mouth locking related to disorders of the temporomandibular joint are not uncommon. As a result of joint laxity, the mandible shifts to one side. The coronoid process then becomes locked lateral to the zygomatic arch. These patients present with the mouth opened and an inability to close the mouth. This article describes a case of intermittent open-mouth mandibular locking in a cat and a modified surgical treatment combining zygomatic arch and coronoid process reduction.
2

Arwyn-Jones, James, and Ashwin Kerai. "Recurrent mouth ulcers." InnovAiT: Education and inspiration for general practice 12, no. 3 (January 17, 2019): 137–43. http://dx.doi.org/10.1177/1755738018794719.

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Mouth ulcers are common and produce a variety of symptoms, ranging from intermittent discomfort to debilitating pain with effects on speech, chewing and swallowing. Clinically, mouth ulcers can be challenging, as a wide range of diagnoses can give rise to lesions of similar appearance. Although the majority of lesions are benign and require little clinical input, others may signify undiagnosed systemic disease or malignancy, warranting prompt investigation and treatment. Separation of differential diagnoses is driven largely by a thorough history and identification of malignant features on examination. We provide an overview of mouth ulcers and a guide to management.
3

Nehme, Rafaela, Flávia M. S. de Branco, Públio F. Vieira, Ana Vitória C. Guimarães, Gederson K. Gomes, Gabriela P. Teixeira, Pedro H. Rodrigues, et al. "Single and Serial Carbohydrate Mouth Rinsing Do Not Improve Yo-Yo Intermittent Recovery Test Performance in Soccer Players." International Journal of Sport Nutrition and Exercise Metabolism 32, no. 1 (January 1, 2022): 22–29. http://dx.doi.org/10.1123/ijsnem.2021-0174.

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Carbohydrate (CHO) mouth rinsing seems to improve performance in exercises lasting 30–60 min. However, its effects on intermittent exercise are unclear. It is also unknown whether serial CHO mouth rinses can promote additional ergogenic effects when compared with a single mouth rinse. The aim of this study was to evaluate the effect of single and serial CHO mouth rinses on Yo-Yo Intermittent Recovery Test Level 1 (Yo-Yo IR1) performance in soccer players. In a randomized, crossover, double-blind, placebo-controlled design, 12 male (18.9 ± 0.5 years) soccer players performed eight serial mouth rinses under three different conditions: placebo solution only (noncaloric juice), seven placebo mouth rinses plus a single CHO mouth rinse (8% maltodextrin), or eight CHO mouth rinses (8-CHO). Following the final mouth rinse, individuals performed the Yo-Yo IR1 test to evaluate the maximal aerobic endurance performance measured via total distance covered. There were no differences in Yo-Yo IR1 performance between sessions (p = .32; single CHO mouth rinse (8% maltodextrin): 1,198 ± 289 m, eight CHO mouth rinses: 1,256 ± 253 m, placebo: 1,086 ± 284 m). In conclusion, single and serial CHO mouth rinsing did not improve performance during the Yo-Yo IR1 for soccer players. These data suggest that CHO mouth rinsing is not an effective ergogenic strategy for intermittent exercise performance irrespective of the number of rinses.
4

Lewis, D. D., R. D. Pechman, and M. G. Oakes. "Intermittent Open Mouth Locking in a Persian Cat." Veterinary and Comparative Orthopaedics and Traumatology 3, no. 03 (1990): 97–99. http://dx.doi.org/10.1055/s-0038-1633236.

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Intermittent open mouth locking occurred in a Persian cat as the result of impingement of the left coronoid process of the mandible on the ipsilateral zygomatic arch. The condition was treated successfully by partial zygomatic arch ostectomy.
5

Orescanin, Mara M., Liliana Velasquez Montoya, John Plant, Cynthia Williamson, and Collin Brennan. "MORPHODYNAMICS AT THE MOUTH OF A BAR-BUILT ESTUARY: CARMEL RIVER, CA, USA." Coastal Engineering Proceedings, no. 37 (September 1, 2023): 43. http://dx.doi.org/10.9753/icce.v37.sediment.43.

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Bar-built estuaries (BBEs), also known as Intermittently Closed Estuaries (ICEs), are common to coastal climates with a strong seasonal precipitation pattern and waves including the US West Coast, Australia, South Africa, and Western Europe (McSweeney et al, 2017). In California, USA, these BBEs typically go through seasonal morphological transitions from a closed state to open state as precipitation increases during the winter months. However, timing of these events is challenging owing to variable behavior for given environmental forcing conditions, and as a result often lead to intermittent flooding of the surrounding areas that is difficult to predict (Behrens et al., 2013; Orescanin and Scooler, 2018). This study uses a compilation of observations using in-situ moorings, topographic beach surveys, and remote sensing from unmanned aerial systems (UAS) to assess rates of morphological change at the Carmel River, CA, USA.
6

Rollo, Ian, George Homewood, Clyde Williams, James Carter, and Vicky L. Goosey-Tolfrey. "The Influence of Carbohydrate Mouth Rinse on Self-Selected Intermittent Running Performance." International Journal of Sport Nutrition and Exercise Metabolism 25, no. 6 (December 2015): 550–58. http://dx.doi.org/10.1123/ijsnem.2015-0001.

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This study investigated the influence of mouth rinsing a carbohydrate solution on self-selected intermittent variable-speed running performance. Eleven male amateur soccer players completed a modified version of the Loughborough Intermittent Shuttle Test (LIST) on 2 occasions separated by 1 wk. The modified LIST allowed the self-selection of running speeds during Block 6 of the protocol (75–90 min). Players rinsed and expectorated 25 ml of noncaloric placebo (PLA) or 10% maltodextrin solution (CHO) for 10 s, routinely during Block 6 of the LIST. Self-selected speeds during the walk and cruise phases of the LIST were similar between trials. Jogging speed was significantly faster during the CHO (11.3 ± 0.7 km·h−1) than during the PLA trial (10.5 ± 1.3 km · h−1) (p = .010); 15-m sprint speeds were not different between trials (PLA: 2.69 ± 0.18 s: CHO: 2.65 ± 0.13 s) (F(2, 10), p = .157), but significant benefits were observed for sprint distance covered (p = .024). The threshold for the smallest worthwhile change in sprint performance was set at 0.2 s. Inferential statistical analysis showed the chance that CHO mouth rinse was beneficial, negligible, or detrimental to repeated sprint performance was 86%, 10%, and 4%, respectively. In conclusion, mouth rinsing and expectorating a 10% maltodextrin solution was associated with a significant increase in self-selected jogging speed. Repeated 15-m sprint performance was also 86% likely to benefit from routinely mouth rinsing a carbohydrate solution in comparison with a taste-matched placebo.
7

Seeman, Kristyn, and Jamie Caso. "Clinical Issues — July 2024." AORN Journal 120, no. 1 (June 25, 2024): 50–55. http://dx.doi.org/10.1002/aorn.14168.

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THIS MONTH Cleaning surgical instruments after use in a procedure involving chemotherapeutic medications Key words: deactivation, decontamination, cleaning, disinfection, chemotherapeutic medication. Paper count sheets sterilized inside instrument sets Key words: count sheets, instrument sets, printer ink, toner, toxicity. Off‐label use of dental devices during direct laryngoscopy Key words: mouth guard, dental injury, direct laryngoscopy, anesthesia, intubation. Using intermittent pneumatic compression devices on patients in lithotomy position Key words: mechanical compression devices, compartment syndrome, lithotomy, venous thromboembolism, thromboprophylaxis.
8

Bach, John R., Augusta S. Alba, George Bohatiuk, Lou Saporito, and Mathew Lee. "Mouth Intermittent Positive Pressure Ventilation in the Management of Postpolio Respiratory Insufficiency." Chest 91, no. 6 (June 1987): 859–64. http://dx.doi.org/10.1378/chest.91.6.859.

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9

Ye, Juan, Hong Chen, and Hong-Gang Zhang. "Continuous versus intermittent bolus milk feeding in preterm infants: a meta-analysis." Journal of International Medical Research 48, no. 9 (September 2020): 030006052095098. http://dx.doi.org/10.1177/0300060520950981.

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Objectives To analyze the evidence comparing the benefits and risks of continuous versus intermittent milk feeding in low birth weight (LBW) infants. Methods Three electronic databases were searched and screened to identify randomized controlled trials of continuous and intermittent milk feeding of LBW infants up to October 2016. Results Eight trials were included in this meta-analysis. Continuous feeding had no effect on days to full feeds and time to regain birth weight. There were no significant differences in the number of apneas, invasive ventilation, changes in body length, occipitofrontal circumference, skinfold thickness, and total protein, and in the number of stools between the two feeding strategies. Continuous feeding was associated with higher gastric residual volume, noninvasive ventilation, weight gain, increase in bilirubin, and longer nil by mouth. There were no significant differences in adverse events and confounders between the two feeding strategies. Conclusions Continuous milk feeding was superior to intermittent feeding in LBW infants in terms of weight gain. However, continuous feeding was also associated with increased nil by mouth duration, increased bilirubin, increased noninvasive support, and increased gastric residuals. Continuous feeding thus confers advantages in terms of weight gain, but also has disadvantages compared with bolus feeding.
10

Paravicini, D., U. Hartenauer, and P. Lawin. "Ventilation in Emergency Situations and During Transport." Journal of the World Association for Emergency and Disaster Medicine 3, no. 1 (1987): 33–36. http://dx.doi.org/10.1017/s1049023x00028685.

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In acute respiratory failure, an immediate restoration of respiratory functions is imperative. Depending upon the available equipment and the qualifications of the physician and nursing staff, the most suitable ventilation procedure should be selected. In every case, accurate ventilation is accomplished by Intermittent Positive Pressure Ventilation (IPPV). If emergency equipment is not available, the simplest method of achieving this is mouth-to-mouth or mouth-to-nose breathing. The efficacy of this method is limited by the low FiO2 (about 17%) and by the physical condition of the first aider; after 30 minutes of resuscitation, even an experienced and well conditioned emergency rescuer will be exhausted.
11

Karayiğit, Raci, Hakan Karabıyık, Burak C. Yaslı, Mitat Koz, and Gulfem Ersoz. "The effect of carbohydrate mouth rinse on intermittent sprint performance in soccer players." Ortadoğu Tıp Dergisi 9, no. 4 (December 15, 2017): 183–90. http://dx.doi.org/10.21601/ortadogutipdergisi.359888.

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Garg, Aayush Kumar, Tripti Tikku, Kamna Srivastava, Rohit Khanna, Rana Pratap Maurya, and Sneh Lata Verma. "Intermittent vibratory stimulation to accelerate tooth movement: A clinical study." IP Indian Journal of Orthodontics and Dentofacial Research 7, no. 3 (October 15, 2021): 237–44. http://dx.doi.org/10.18231/j.ijodr.2021.038.

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Vibratory stimulus is non-invasive and non-pharmacologic method for acceleration of Orthodontic tooth movement in adult patients. As powered toothbrush can provide cheaper alternative to Acceledent (a patent and expensive device) it was decided to evaluate the effectiveness of vibratory stimulation from powered toothbrush as a method of accelerating individual canine retraction. Sample consisted of 24 patients undergoing fixed Orthodontic treatment, in whom separate canine retraction was planned after extraction of all first premolars using NiTi closed coil spring. Force was standardized as 150 grams and checked at each appointment using Dontrix gauge. Following split mouth study design, right side was the experimental side where patients were asked to apply the vibratory stimulus through powered tooth brush (133Hz frequency) for 6 minutes (3 minutes labially and 3 minutes palatally) three times daily at regular intervals for a period of 3 months. Study models were taken at T0 (start of canine retraction), T1 (after 1st month), T2 (after 2nd month) and T3 (after 3rd month). Mean amount of canine movement and molar movement with respect to 3rd palatine rugae was measured on Digimizer software on both the sides for different time intervals. Statistically significant increase in canine movement was seen for total canine movement (T0-T3), movement from T0-T1 and from T2-T3. There was statistically insignificant difference in mesial movement of molars for different time intervals. There was an increased rate of canine movement on the side of vibratory stimulation (right side) in comparison to the control side (left side) for all time intervals and can be used to decrease treatment time in adults.
13

Sharma, Vineet, Supriya Nambiar, Poornima Manjrekar, Asavari Desai, and Pramod Philip. "Assessment of Myeloperoxidase Levels In Relation to the Nature and Duration of Orthodontic Forces – An In vivo, Split Mouth Study." Biomedical and Pharmacology Journal 11, no. 4 (November 28, 2018): 2061–67. http://dx.doi.org/10.13005/bpj/1583.

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To assess the change in the myeloperoxidase levels(MPO)in the gingival crevicular fluid(GCF) at different time intervals during the course of orthodontic treatment with the application of intermittent and continuous forces. It was an interventional, split mouth study done on twenty patients scheduled to undergo fixed orthodontic treatment with therapeutic extractions of the first premolars.Mini implant assisted enmasse retraction was done after leveling and aligning of the arch.Continuous force with the help of Niti coil spring was used in the first quadrant and intermittent force with an elastomeric chain was used in the second quadrant. MPO was collected from the GCF using What man’s paper at baseline,1 week and 2 weeks after the application of retraction forces.The levels were assessed using a commercially available ELISA kit. Mean MPO activity was increased in the GCF of all the patients at 1 and 2 weeks after retraction,in both quadrants.At 2 weeks, MPO levels at the intermittent force application site were found to be significantly higher than those at the site of continuous force application. Myeloperoxidase is a useful marker to assess inflammation associated with orthodontic tooth movement.Intermittent forces cause a higher degree of inflammation as compared to continuous forces.
14

Jarvis, S. J., and P. D. Bull. "Hairy polyps of the nasopharynx." Journal of Laryngology & Otology 116, no. 6 (June 2002): 467–69. http://dx.doi.org/10.1258/0022215021911095.

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Hairy polyps are rare tumours that can occur anywhere in the body. They are especially rare in the pharynx. We report two cases of hairy polyps which originated from the nasopharynx. One presentedwith intermittent obstruction of the airway and the second presented as a visible pedunculated mass protruding from the mouth of a neonate.
15

Jagtap, Sneha B., Veera I. Bhosale, and Amol S. Patil. "Comparative evaluation of interrupted and intermittent forces on canine retraction: an in vivo study." Folia Medica 63, no. 5 (October 31, 2021): 686–91. http://dx.doi.org/10.3897/folmed.63.e54247.

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Introduction: Various force systems are used in orthodontics to move teeth, such as continuous, intermittent and interrupted. Teeth responds differently to these orthodontic forces. Aims: The aim of the study is to compare the rate of canine retraction with intermittent and interrupted forces. Materials and Methods: A split mouth study was carried among eighteen participants. One side of maxillary arch randomly received interrupted force with elastomeric powerchain while other received intermittent force with elastics with magnitude of 150-170g for canine retraction on each side. For 15 weeks, participants were asked to wear the elastics 8 hours a day whereas the elastomeric powerchains were replaced by operator every 5 weeks. The outcomes were assessed using scanned images of study models collected at the beginning (T0) and 15 weeks later (T3) as well on OPG. Linear and angular measurements were used to measure the distal movement, rotation as well tipping of canines and the results were statistically analysed using Independent t-test. Results: The distal movement of canine on the interrupted force side was 0.98mm/5weeks and on the intermittent force side was 1.06mm/5weeks. The distopalatal rotation on interrupted and intermittent force side was 8.38° and 5.72°. Tipping measured on OPG was 5.72° and 5.27° for interrupted and intermittent force. No statistically significant differences were found. Conclusion: The rate of canine retraction with interrupted force and intermittent force showed no statistically significant differences. Less canine rotation and tipping with intermittent force compared to interrupted force though not statistically significant.
16

Janović, Aleksa, Đurđa Bracanović, Svetlana Antić, and Biljana Marković-Vasiljković. "Submandibular swelling, pulsations and otalgia due to sublingual gland and blood vessels herniation through mylohyoid boutonnière: Case report." Balkan Journal of Dental Medicine 26, no. 1 (2022): 58–62. http://dx.doi.org/10.5937/bjdm2201058j.

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Background/Aim: Mylohyoid boutonnière is a common anatomical variant with extremely rare clinical manifestations. We report two cases of symptomatic unilateral mylohyoid boutonnière with sublingual gland herniation. Case report: The first was a 34-year-old female with a two months history of a left submandibular swelling, intermittent pulsations, and otalgia. The second 67-year-old female presented with a left submandibular pain six months after total thyroidectomy due to papillary carcinoma. After detailed clinical and radiological evaluation by ultrasonography (US) and computed tomography (CT), the mylohyoid gap with sublingual gland herniation was diagnosed in both patients. The dynamic US with a tongue pressed down on the mouth floor revealed blood vessel compression by a herniated sublingual gland in the first patient. Conclusions: This is the first case of a mylohyoid boutonnière related intermittent vascular compression. Dynamic US and CT may help to differentiate intermittent and persistent sublingual gland herniation through the mylohyoid boutonnière from other pathological lesions in the submandibular region.
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Bazzucchi, Ilenia, Federica Patrizio, Francesco Felici, Andrea Nicolò, and Massimo Sacchetti. "Carbohydrate Mouth Rinsing: Improved Neuromuscular Performance During Isokinetic Fatiguing Exercise." International Journal of Sports Physiology and Performance 12, no. 8 (September 2017): 1031–38. http://dx.doi.org/10.1123/ijspp.2016-0583.

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Purpose:To determine whether repeated carbohydrate (CHO) mouth rinsing would improve neuromuscular performance during high-intensity fatiguing contractions.Methods:Eighteen young men (age 26.1 ± 5.0 y, BMI 22.9 ± 1.9) performed 3 maximal voluntary isometric contractions (MVICPRE). Immediately after, they completed 10-second mouth rinse with 6.4% maltodextrin solution (MAL), 7.1% glucose solution (GLU), water (W), artificially sweetened solution (PLA), or a control trial with no rinse (CON) in a crossover protocol. Subjects performed 5 sets of 30 isokinetic fatiguing contractions at 180°/s, and an MVICPOST with their elbow flexors was performed after each mouth rinse. Mechanical and electromyographic (EMG) signals were recorded from the biceps brachii and parameters of interest analyzed.Results:When rinsing the mouth with a solution containing CHO, independently of the sweetness, isokinetic performance was enhanced as shown by the greater total work achieved in comparison with CON. The decay of torque and mean fiber-conduction velocity (MFCV) recorded at the end of the fatiguing task was lower when rinsing the mouth with GLU than with CON. The torque recorded during the MVICPOST was greater with CHO with respect to CON, and this was associated to a lower decay of MFCV.Conclusions:CHO mouth rinse counteracts fatigue-induced decline in neuromuscular performance, supporting the notion that CHO rinse may activate positive afferent signals able to modify motor output. Repeated mouth rinsing with sweet and nonsweet CHO-containing solutions can improve neuromuscular performance during an isokinetic intermittent fatiguing task.
18

Bhardwaj, Viny, Vimmi Gautam, Hitesh Verma, and Mayank Dilip Bhutada. "Lost and found: foreign body in submandibular gland." BMJ Case Reports 16, no. 11 (November 2023): e257564. http://dx.doi.org/10.1136/bcr-2023-257564.

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A young adult male patient presented with the history of a retained foreign body in the oral cavity. The object in question was a stapler pin that got accidentally lodged while the patient tried removing food particles from his mouth 28 days earlier. Aside from intermittent pain upon digital palpation on the right side of the floor of his mouth, he was asymptomatic. Clinical examination was unremarkable. Plain radiography and a computed tomogram revealed a linear foreign body in the right submandibular gland. The patient underwent a submandibular gland excision, during which a 2 cm long stapler pin was retrieved. This case highlights that not all foreign bodies cause inflammatory reactions as a telltale sign of their presence.
19

Beaven, C. Martyn, Peter Maulder, Adrian Pooley, Liam Kilduff, and Christian Cook. "Effects of caffeine and carbohydrate mouth rinses on repeated sprint performance." Applied Physiology, Nutrition, and Metabolism 38, no. 6 (June 2013): 633–37. http://dx.doi.org/10.1139/apnm-2012-0333.

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Our purpose was to examine the effectiveness of carbohydrate and caffeine mouth rinses in enhancing repeated sprint ability. Previously, studies have shown that a carbohydrate mouth rinse (without ingestion) has beneficial effects on endurance performance that are related to changes in brain activity. Caffeine ingestion has also demonstrated positive effects on sprint performance. However, the effects of carbohydrate or caffeine mouth rinses on intermittent sprints have not been examined previously. Twelve males performed 5 × 6-s sprints interspersed with 24 s of active recovery on a cycle ergometer. Twenty-five milliliters of either a noncaloric placebo, a 6% glucose, or a 1.2% caffeine solution was rinsed in the mouth for 5 s prior to each sprint in a double-blinded and balanced cross-over design. Postexercise maximal heart rate and perceived exertion were recorded, along with power measures. A second experiment compared a combined caffeine-carbohydrate rinse with carbohydrate only. Compared with the placebo mouth rinse, carbohydrate substantially increased peak power in sprint 1 (22.1 ± 19.5 W; Cohen's effect size (ES), 0.81), and both caffeine (26.9 ± 26.9 W; ES, 0.71) and carbohydrate (39.1 ± 25.8 W; ES, 1.08) improved mean power in sprint 1. Experiment 2 demonstrated that a combination of caffeine and carbohydrate improved sprint 1 power production compared with carbohydrate alone (36.0 ± 37.3 W; ES, 0.81). We conclude that carbohydrate and (or) caffeine mouth rinses may rapidly enhance power production, which could have benefits for specific short sprint exercise performance. The ability of a mouth-rinse intervention to rapidly improve maximal exercise performance in the absence of fatigue suggests a central mechanism.
20

Bach, John R., Augusta S. Alba, and Louis R. Saporito. "Intermittent Positive Pressure Ventilation via the Mouth as an Alternative to Tracheostomy for 257 Ventilator Users." Chest 103, no. 1 (January 1993): 174–82. http://dx.doi.org/10.1378/chest.103.1.174.

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Shirai, Asako, Tsuyoshi Wadazumi, Yoko Hirata, Naomi Hamada, and Nobuko Hongu. "Carbohydrate Mouth Rinse and Spray Improve Prolonged Exercise Performance in Recreationally Trained Male College Students." Sports 10, no. 4 (March 29, 2022): 51. http://dx.doi.org/10.3390/sports10040051.

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Mouth rinsing with a carbohydrate (CHO) solution has emerged as a sports nutrition strategy to increase endurance performance. This study aimed to clarify the effects of two forms of CHO sensing in the mouth (i.e., CHO mouth rinse (CMR) and CHO mouth spray (CMS)) on exercise performance during prolonged exercise, including ultra-high intensity intermittent exercise over time. We conducted the following experimental trials: (1) 6% glucose solution (G), (2) 6% CMR, (3) 6% CMS, and (4) water (WAT). These trials were conducted at least 1 week apart in a randomized crossover design. Eight male college students performed constant-load exercise for 60 min (intensity 40% VO2peak), four sets of the Wingate test (three 30 s Wingate tests with a 4 min recovery between each test), and a constant-load exercise for 30 min (intensity 40% VO2peak). The mean exercise power output (Watt), ratings of perceived exertion, and blood glucose levels were measured. We found that the mean power values of the CMR and CMS in the third and fourth sets was significantly higher than that of WAT (p < 0.05), and that the G trial did not show a significant difference from any other trial. Thus, when compared to G or WAT, CMR and CMS can help improve endurance exercise performance.
22

ALIAH, NUR FILZAH. "Energy Dense Feeding in Premature Infants and Its’ Associated Outcomes." Jurnal Sains Kesihatan Malaysia 22, no. 1 (January 1, 2024): 59–62. http://dx.doi.org/10.17576/jskm-2024-2201-06.

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COVID-19 infection in pregnant mothers is associated with higher risk of intrauterine growth retardation and premature births. Very low birth weight infants are more susceptible to neurodevelopmental and chronic respiratory problems. An infant delivered at 33 weeks via caesarean section to a COVID-19 Stage 5A positive mother, weighing 1.43kg at birth. She was kept nil by mouth with parenteral nutrition (PN) support since day five of life until referred to dietitian on day 22 of life for enteral nutrition (EN) establishment. Feeding was administered intermittently via oro-gastric Ryle’s Tube. She was kept under non-invasive ventilation (NIV) mode and had difficulty in weaning from ventilation, leading to slow feeding progress. Initially, enteral trophic feeding was administered using premature infant formula fortified with modular products. In the later stage of feeding, modular products were tapered off and the formula was concentrated. Frequency of bowel output when using fortified formula is lesser compared to when using concentrated and supplemented formula. There is no significant difference in renal profile observed in both stages of feeding. Increasing energy intake using easily digestible sources is preferable as opposed to concentrating feeds even further due to concerns about osmolality and excess administration of other solutes. Intermittent bolus feeding mode may have an effect on dependency on oxygen since intermittent feeds can decrease tidal volume, minute ventilation and dynamic compliance. Additional research is necessary to establish optimal caloric density and nutritional compositions of feedings, feeding mechanisms and its’ effect on feeding tolerance.
23

Mitchell, T. E., and A. C. Girling. "Hairy polyp of the tonsil." Journal of Laryngology & Otology 110, no. 1 (January 1996): 101–3. http://dx.doi.org/10.1017/s0022215100132852.

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AbstractHairy polyps or dermoids of the oro- and naso-pharynx are benign lesions containing elements of both ectodermal and mesodermal origin. We report a case of a hairy polyp arising from the tonsil in a three-week-old infant. This presented as an intermittent swelling in the mouth, which was successfully removed under general anaesthesia. To our knowledge this is only the third case of a hairy polyp arising at this site to be reported. We discuss the terminology applied to these lesions and review the literature.
24

Singh, Suyash Pratap, Anish Kr Maity, Rahul Pandey, Nirma Bharati, and Manoj Kumar Hans. "Root to recovery: Successfully healing a large periapical lesion in the mandibular first molar: A case report." IP Indian Journal of Conservative and Endodontics 9, no. 1 (March 15, 2024): 49–52. http://dx.doi.org/10.18231/j.ijce.2024.011.

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This case report presents the diagnosis, successful management, and healing of a large periapical lesion associated with the mandibular first molar teeth The patient's chief complaint was severe, intermittent pain in the lower right posterior region of the mouth, and radiographic examination revealed a substantial periapical radiolucency around the apices of the mandibular first molar. The treatment involved root canal therapy along with adjunctive procedures to promote healing of the periapical lesion. Follow-up radiographs demonstrated a significant reduction of the periapical lesion with complete resolution of symptoms.
25

Pervez, Hira. "Triple Lumen Esophagus; A Rare Congenital Anomaly Presenting with Dysphagia." Research International Journal of Surgery and Medicine 01, no. 01 (October 16, 2020): 004–6. http://dx.doi.org/10.37179/rijsm.000002.

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Alimentary tract duplications are rare congenital malformations that can occur at any level of the gastrointestinal (GI) tract from mouth to anus. Triple lumen esophagus is even rarer occurrence and has not been reported previously according to our literature search. The diagnosis is often confused with esophageal tract duplication secondary to perforation or surgeries leading to Gastroesophageal 􀏐istula formation. A middle-aged female presented to us with an intermittent history of dysphagia and gastroesophageal re􀏐lux disease (GERD) and was diagnosed with a triple lumen esophagus radiographically, endoscopically which was con􀏐irmed and managed surgically.
26

Mowafy, Mohamed I., and Abbas R. Zaher. "Anchorage loss during canine retraction using intermittent versus continuous force distractions; a split mouth randomized clinical trial." Progress in Orthodontics 13, no. 2 (September 2012): 117–25. http://dx.doi.org/10.1016/j.pio.2011.12.005.

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Bellando-Randone, Silvia, Edda Russo, Vincenzo Venerito, Marco Matucci-Cerinic, Florenzo Iannone, Sabina Tangaro, and Amedeo Amedei. "Exploring the Oral Microbiome in Rheumatic Diseases, State of Art and Future Prospective in Personalized Medicine with an AI Approach." Journal of Personalized Medicine 11, no. 7 (June 30, 2021): 625. http://dx.doi.org/10.3390/jpm11070625.

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The oral microbiome is receiving growing interest from the scientific community, as the mouth is the gateway for numerous potential etiopathogenetic factors in different diseases. In addition, the progression of niches from the mouth to the gut, defined as “oral–gut microbiome axis”, affects several pathologies, as rheumatic diseases. Notably, rheumatic disorders (RDs) are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. In this review, we examine evidence which supports a role for the oral microbiome in the etiology and progression of various RDs, including rheumatoid arthritis (RA), Sjogren’s syndrome (SS), and systemic lupus erythematosus (SLE). In addition, we address the most recent studies endorsing the oral microbiome as promising diagnostic biomarkers for RDs. Lastly, we introduce the concepts of artificial intelligence (AI), in particular, machine learning (ML) and their general application for understanding the link between oral microbiota and rheumatic diseases, speculating the application of a possible AI approach-based that can be applied to personalized medicine in the future.
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Warn, Peter, Pia Thommes, Andrew Sharp, Abdul Sattar, Nasrullah Undre, Jose Alejandro Palacios-Fabrega, and Andreas Karas. "Intermittent micafungin for prophylaxis in a rat model of chronic Candida albicans gut colonization." Journal of Antimicrobial Chemotherapy 75, no. 10 (July 28, 2020): 2919–24. http://dx.doi.org/10.1093/jac/dkaa243.

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Abstract Background During antifungal prophylaxis, micafungin is generally infused IV once daily over 1 h. In practice, less-frequent dosing could improve the quality of life in patients requiring long-term treatment or prophylaxis. The feasibility of this approach was assessed using humanized doses of daily or infrequent micafungin regimens. Objectives To evaluate the effectiveness of intermittent high-dose micafungin, simulating human exposure, for prophylaxis of invasive candidiasis in a rat model of chronic Candida albicans gastrointestinal colonization and systemic dissemination. Methods Two weeks post-infection with an oral challenge of C. albicans, Sprague–Dawley rats were immunocompromised with a cytotoxic drug and a steroid. Rats received IV infusions of: daily vehicle control; daily subcutaneous micafungin (20 mg/kg SC); high-dose micafungin (20 mg/kg bolus SC + 80 mg/kg infusion/72 h, to simulate intermittent human dosing of 300 mg/72 h); or daily fluconazole by mouth (10 mg/kg PO). The effects of antifungal prophylaxis on faecal fungal burden and systemic C. albicans dissemination were evaluated. Results A rat model of chronic C. albicans gastrointestinal colonization and systemic dissemination was established, characterized by a sustained microbiological burden over 29 days and fungal recovery from normally sterile tissues. Using this model, intermittent high-dose micafungin (delivered via iPrecio pumps) to simulate humanized doses of 300 mg/72 h was significantly more effective than vehicle control, as effective as once-daily micafungin and similar to daily fluconazole at reducing faecal burden and preventing systemic dissemination. Conclusions These data indicate that intermittent high-dose micafungin can be as effective as daily therapy, supporting clinical assessment in high-risk patients requiring long-term antifungal prophylaxis.
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Fleming, Padraic, Sinead O'Neill, Miriam Owens, Therese Mooney, and Patricia Fitzpatrick. "Intermittent attendance at breast cancer screening." Journal of Public Health Research 2, no. 2 (September 5, 2013): 14. http://dx.doi.org/10.4081/jphr.2013.e14.

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<em>Background</em>. To determine why women skip rounds and factors influencing return of previous non attenders (PNAs) to breast screening. <em></em><br /><em>Design and methods</em>. Retrospective, quantitative, structured questionnaire posted to 2500 women. First PNAs did not attend their first screening appointment in 2007/2008 but then attended in 2010; First Controls first attended in 2010 without missed previous appointments. Women who attended screening in 2006 or earlier then skipped a round but returned in 2010 were Subsequent PNAs; Subsequent Controls attended all appointments.<br /><em>Results</em>. More First Controls than First PNAs had family history of cancer (72.7% <em>vs</em> 63.2%; P=0.003); breast cancer (31.3% <em>vs</em> 24.8%; P=0.04). More PNAs lived rurally; more First PNAs had 3rd level education (33.2% <em>vs</em> 23.6%; P=0.002) and fewer had private insurance than First Controls (57.7% <em>vs</em> 64.8%; P=0.04). Excellent/good health was reported in First PNAs and First Controls (82.9% <em>vs</em> 83.2%), but fewer Subsequent PNAs than Subsequent Controls (72.7% <em>vs</em> 84.9%; P=0.000). Common considerations at time of missed appointment were<em> had mammogram elsewhere</em> (33% First PNA) and <em>postponed to next round</em> (16% First PNA, 18.8% Subsequent PNA). Considerations when returning to screening were similar for First PNAs and Subsequent PNAs: <em>I am older </em>(35.4%, 29.6%), <em>I made sure I remembered</em> (29%, 23.6%), <em>could reschedule</em> (17.6%, 20.6%), <em>illness of more concern</em> (16.5%, 19%). More First PNAs stated <em>my family/friends advised</em> (22.3% <em>vs</em> 15.2%) or<em> my GP</em> (12.6% <em>vs</em> 4.6%) <em>advised me to attend</em>, h<em>eard good things about BreastCheck</em> (28.8% <em>vs</em> 13.6%).<br /><em>Conclusions</em>. Intermittent attenders do not fit socio-demographic patterns of non-attenders; GP recommendation and word of mouth were important in women’s return to screening. Fear and anxiety seem to act as a screening facilitator rather than an inhibitor.<br />
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Nayati, Jasir T., and Alan R. Hirsch. "137 Menstrual Synchrony of Burning Mouth Syndrome." CNS Spectrums 23, no. 1 (February 2018): 86. http://dx.doi.org/10.1017/s1092852918000330.

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AbstractStudy ObjectiveBurning mouth syndrome (BMS) is characterized by oral mucosal burning sensations, with normal clinical and laboratory results. Menstrual synchrony of migraines and epilepsy have been discussed; however, menstrual synchrony of BMS has not heretofore been described.MethodsCase Study: A 29 year old right-handed female exhibited intermittent BMS symptoms, one month after suffering a left parietal infarction. She describes the pain as a burningsensation, localized to the bilateral and anterior aspects of her tongue. It lasts for four days, starts three days prior to her menses, and occurs twice a month. She is unable to correlate any patterns or triggers that may cause to exacerbate her BMS. She denies any taste disturbances, hot-flashes, night sweats, and perspiration.ResultsAbnormalities during neurological examination were noted. Cranial nerves (CN) III, IV, and VI showed bilateral lateral first degree end-gaze unsustained nystagmus. CN IX and X showed decreased bilateral gag reflex. A right pronator drift with a right abductor digiti minimi sign was seen in the motor examination. The cerebellar examination was positive for bilateral dysmetria during the Finger-To-Nose examination, and exhibited Holmes rebound phenomena, right more than left. Sensory examination showed decreased light touch in the lower extremities, right more than left. Hoffman reflex was bilaterally positive. Mental status examinations demonstrated poor similarity interpretation and calculation ability. Her neuropsychiatric testing was normal, and included the Go-No-Go and Animal Fluency Testing. MRI of the brain exhibited gliosis/laminar necrosis in the left inferior parietal lobe, and an 8mm descent of cerebellar tonsils below the foramen magnum.ConclusionThe potential mechanism for catamenial BMS is manyfold. Estrogen and progesterone both have nociceptive properties. Premenstrual drop or reduction of estrogen and progesterone may act to disinhibit pain [Vincent 2008], with pain modulation being more effective during the ovulatory phase (high estrogen and low progesterone) [Rezaii 2012]. Depression in the presence of Late Luteal Phase Dysphoric Disorder may function to exacerbate the perception of underlying pain throughout the body, including the mouth and tongue. Decrease in estrogen and progesterone levels may also alter salivary output and composition. This may allow baseline reduction of proprioceptive input on the tongue, thus acting through Melzack and Wall’s Gate Control Theory of Pain to disinhibit small C fibers, which is perceived as burning pain [Melzack 1978]. Along with menses, olfactory ability drops, and food preferences are often reported to change [Keller 2013]. A decrease in estrogen and progesterone can also enhance trigeminal nerve sensitivity [Martin 2007], which exacerbates pain. This may indirectly influence or be associated with her BMS. Such observations justifies a trial of hormonal agents for therapy of BMS.Funding AcknowledgementsSmell and Taste Treatment and Research Foundation
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Mears, Stephen A., and Susan M. Shirreffs. "The Effects of High-Intensity Intermittent Exercise Compared With Continuous Exercise on Voluntary Water Ingestion." International Journal of Sport Nutrition and Exercise Metabolism 23, no. 5 (October 2013): 488–97. http://dx.doi.org/10.1123/ijsnem.23.5.488.

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Water intake occurs following a period of high-intensity intermittent exercise (HIIE) due to sensations of thirst yet this does not always appear to be caused by body water losses. Thus, the aim was to assess voluntary water intake following HIIE. Ten healthy males (22 ± 2 y, 75.6 ± 6.9 kg, VO2peak 57.3 ± 11.4 m·kg−1·min−1; mean± SD) completed two trials (7–14 d apart). Subjects sat for 30 min then completed an exercise period involving 2 min of rest followed by 1 min at 100% VO2peak repeated for 60 min (HIIE) or 60 min continuously at 33% VO2peak (LO). Subjects then sat for 60 min and were allowed ad libitum water intake. Body mass was measured at start and end of trials. Serum osmolality, blood lactate, and sodium concentrations, sensations of thirst and mouth dryness were measured at baseline, postexercise and after 5, 15, 30, and 60 min of recovery. Vasopressin concentration was measured at baseline, postexercise, 5 min, and 30 min. Body mass loss over the whole trial was similar (HIIE: 0.77 ± 0.50; LO: 0.85 ± 0.55%; p = .124). Sweat lost during exercise (0.78 ± 0.22 vs. 0.66 ± 0.26 L) and voluntary water intake during recovery (0.416 ± 0.299 vs. 0.294 ± 0.295 L; p < .05) were greater in HIIE. Serum osmolality (297 ± 3 vs. 288 ± 4mOsmol·kg−1), blood lactate (8.5 ± 2.7 vs. 0.7 ± 0.4 mmol·L−1), serum sodium (146 ± 1 vs. 143 ± 1 mmol·L−1) and vasopressin (9.91 ± 3.36 vs. 4.43 ± 0.86 pg·ml−1) concentrations were higher after HIIE (p < .05) and thirst (84 ± 7 vs. 60 ± 21) and mouth dryness (87 ± 7 vs. 64 ± 23) also tended to be higher (p = .060). Greater voluntary water intake after HIIE was mainly caused by increased sweat loss and the consequences of increased serum osmolality mainly resulting from higher blood lactate concentrations.
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Knoche, Luke W., Colton E. Belitz, and Brian S. Snyder. "Effects Of Carbohydrate Mouth Rinsing On Depleted-State Wrestlers Using A Yo-yo Ir Level 2 Intermittent Test." Medicine & Science in Sports & Exercise 48 (May 2016): 61. http://dx.doi.org/10.1249/01.mss.0000485193.97398.8a.

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Dolan, Patrick, Kyle E. Witherbee, Kimi M. Peterson, and Chad M. Kerksick. "Effect of Carbohydrate, Caffeine, and Carbohydrate + Caffeine Mouth Rinsing on Intermittent Running Performance in Collegiate Male Lacrosse Athletes." Journal of Strength and Conditioning Research 31, no. 9 (September 2017): 2473–79. http://dx.doi.org/10.1519/jsc.0000000000001819.

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Joumar, Nada, Soumaya Nabih, Antonis Chatzipavlis, Adonis Velegrakis, Thomas Hasiotis, Ourania Tzoraki, Jamal Eddine Stitou El Messari, and Lahcen Benaabidate. "A Qualitative Assessment of River Plumes Coupling SWAT Model Simulations and a Beach Optical Monitoring System." Hydrology 10, no. 2 (January 30, 2023): 38. http://dx.doi.org/10.3390/hydrology10020038.

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The study of plumes occurring at the mouth of small rivers of temporal flow is a challenging task due to the lack of sedimentological and flow data of appropriate spatiotemporal scales. The present contribution examined the case of a typical un-gauged intermittent Mediterranean stream located in Northern Crete (Xiropotamos river). The SWAT (soil and water assessment tool) model was used to simulate and reproduce the hydrological behavior of the adjacent intermittent (Giofyros) river discharging at the same beach, the basin of which has the same geomorphological and hydrological characteristics. The output of the calibrated SWAT model was used to simulate daily flow data for the year 2014. The results were then considered together with the results of the RGB analysis of optical datasets of high spatio-temporal resolution for the same period, derived from a beach optical monitoring system (BOMS). The RGB analysis of the optical (TIMEX) imagery was shown to be a useful technique to identify and classify coastal plumes by using the spatio-temporal variability of pixel properties. The technique was also shown to be useful for the (qualitative) validation of the SWAT output and could be further improved by the collection of ‘ground truth’ data.
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Soria, Jean-Charles, John H. Strickler, Ramaswamy Govindan, Seungjean Chai, Nancy Chan, Vanesa Quiroga-Garcia, Rastislav Bahleda, et al. "Safety and activity of the pan-fibroblast growth factor receptor (FGFR) inhibitor erdafitinib in phase 1 study patients (Pts) with molecularly selected advanced cholangiocarcinoma (CCA)." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 4074. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.4074.

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4074 Background: Erdafitinib (JNJ-42756493) is a potent, oral pan-FGFR tyrosine kinase inhibitor that demonstrated encouraging preliminary clinical activity and manageable adverse events (AEs) in its first-in-human phase 1 study in advanced solid tumors (NCT01703481). Here we report results from pts with CCA from this study. Methods: This 4-part study enrolled pts age ≥ 18 years (y) with advanced solid tumors. Dose escalation (part 1) followed a 3+3 design, with pts receiving ascending doses of erdafitinib continuously or intermittently (7 days on/7 days off). Subsequent parts required FGFR gene alterations in the tumor, including activating mutations and translocations or other FGFR-activating aberrations. Part 2 was a pharmacodynamics cohort. Parts 3 and 4 were dose-expansion cohorts for recommended phase 2 doses of 9 mg once daily (QD) and 10 mg intermittently, respectively. Results: Eleven pts with FGFR-aberrant CCA were treated at 9 mg QD (n = 1) or 10 mg intermittent (n = 10). Median age was 60 y; 7 of 11 pts were female (64%). 73% of pts had ECOG performance status 1. All had prior systemic therapy. Median treatment duration with erdafitinib was 5.3 months (mo). Systemic erdafitinib exposure, per Cmax and AUC, in CCA pts was similar to other indications. The most common AEs were stomatitis (82%), hyperphosphatemia (64%), dry mouth (55%), dysgeusia (45%), dry skin (45%), and asthenia (45%), mostly grade 1/2 severity. No drug-related grade ≥3 AEs were reported in > 1 pt except grade 3 stomatitis (n = 2; 18%). The objective response rate, all confirmed partial responses (PRs) per RECIST 1.1, was 27.3% (3/11; 95% CI 6, 61); an additional 27.3% (3/11) had stable disease as their best response. Overall disease control rate was 55%. All 3 PRs were at the 10 mg intermittent dosage, and the median duration of response was 12.9 mo. With a median follow-up of 5.1 mo, median progression-free survival was 5.1 mo (95% CI 1.6, 16.4). As of the cutoff date, 2 pts continue on study treatment. Conclusions: Erdafitinib showed encouraging clinical activity and minimal toxicity in pts with advanced CCA and FGFR alterations. These results warrant further study. Clinical trial information: NCT01703481.
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Kuna, S. T., and J. Smickley. "Response of genioglossus muscle activity to nasal airway occlusion in normal sleeping adults." Journal of Applied Physiology 64, no. 1 (January 1, 1988): 347–53. http://dx.doi.org/10.1152/jappl.1988.64.1.347.

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To determine the combined effect of increased subatmospheric upper airway pressure and withdrawal of phasic volume feedback from the lung on genioglossus muscle activity, the response of this muscle to intermittent nasal airway occlusion was studied in 12 normal adult males during sleep. Nasal occlusion at end expiration was achieved by inflating balloon-tipped catheters located within the portals of a nose mask. No seal was placed over the mouth. During nose breathing in non-rapid-eye-movement (NREM) sleep, nasal airway occlusion resulted in multiple respiratory efforts before arousal. Mouth breathing was not initiated until arousal. Phasic inspiratory genioglossus activity was present in eight subjects during NREM sleep. In these subjects, comparison of peak genioglossus inspiratory activity on the first three occluded efforts to the value just before occlusion showed an increase of 4.7, 16.1, and 28.0%, respectively. The relative increases in peak genioglossus activity were very similar to respective increases in peak diaphragm activity. Arousal was associated with a large burst in genioglossus activity. During airway occlusion in rapid-eye-movement (REM) sleep, mouth breathing could occur without a change in sleep state. In general, genioglossus responses to airway occlusion in REM sleep were similar in pattern to those in NREM sleep. A relatively small reflex activation of upper airway muscles associated with a sudden increase in subatmospheric pressure in the potentially collapsible segment of the upper airway may help compromise upper airway patency during sleep.
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Acharya, Sudeep, Amita Pradhan, Rajib Chaulagain, and Ankur Shah. "Temporomandibular Joint Disorders and its Relationship with Parafunctional Habits among Undergraduate Medical and Dental Students." Journal of College of Medical Sciences-Nepal 14, no. 3 (September 30, 2018): 154–59. http://dx.doi.org/10.3126/jcmsn.v14i3.20289.

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Background: Temporomandibular disorder is a term used to describe problems involving temporomandibular joint, muscles of mastication, occlusion characterized by symptoms such as pain, restricted movements and intermittent joint sound. The present study was conducted to determine prevalence of TMD and to describe its association with parafunctional habits. Materials and Methods: A cross-sectional study was carried out among 345 undergraduate students of KIST Medical College and Hospital. Study population was selected by simple random sampling and the Fonseca Anamnestic Questionnaires were distributed. Data analysis was done in SPSS version 16 . Results: The prevalence of TMD was 47.4% with mild and moderate type of TMD present. The most common habit was chewing gums followed by biting of lips and biting of objects. Statistically significant difference in TMD groups was observed in clenching and grinding of teeth, biting of lips and biting of objects (p<0.001). There was statistically significant association between TMD and the signs and symptoms such as headaches, difficult to open mouth, muscular pain while chewing (p<0.001). Conclusions: A statistically significant association was found between biting of lips, grinding of teeth and mouth breathing with TMD.Keywords: parafunctional habits; prevalence; TMD .
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Gibson, O. R., J. G. Wrightson, and M. Hayes. "Intermittent sprint performance in the heat is not altered by augmenting thermal perception via L-menthol or capsaicin mouth rinses." European Journal of Applied Physiology 119, no. 3 (December 22, 2018): 653–64. http://dx.doi.org/10.1007/s00421-018-4055-0.

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39

Foster, Stephen P., and Karin G. Anderson. "Sex pheromone biosynthesis, storage and release in a female moth: making a little go a long way." Proceedings of the Royal Society B: Biological Sciences 287, no. 1941 (December 16, 2020): 20202775. http://dx.doi.org/10.1098/rspb.2020.2775.

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Moth pheromone research has pioneered much of our understanding of long-distance chemical communication. Two important characteristics of this communication have, however, remained largely unaddressed: the release of small quantities of pheromone by most moth species, despite potential advantages of releasing greater amounts, and the intermittency of release in some species, limiting the time of mate attraction. We addressed the proximate mechanisms underlying these characteristics by manipulating biosynthesis, storage and release of pheromone in females of the noctuid moth Chloridea virescens . We found that (i) mass release is determined by pheromone mass on the gland surface; (ii) amounts synthesized are limited by pheromone biosynthesis activating neuropeptide concentration, not precursor availability; (iii) some gland structural feature limits mass release rate; (iv) intermittent calling enables release at a mass rate greater than biosynthetic rate; and (v) at typical mass release rates, the periodicity of pheromone availability on the gland surface roughly matches the periodicity (intermittency) of calling. We conclude that mass release in C . virescens and possibly many other species is low because of constraints on biosynthesis, storage and gland structure. Further, it appears the behaviour of intermittent calling in C. virescens may have evolved as a co-adaptation with pheromone availability, allowing females to release pheromone intermittently at higher mass rates than the biosynthesis rate.
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Saputra, Egon Ilman, and Bambang Suprayogi Resi Utomo. "Association between obstructive sleep apnea and sleep quality." Oto Rhino Laryngologica Indonesiana 53, no. 2 (January 3, 2024): 162–8. http://dx.doi.org/10.32637/orli.v53i2.575.

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Background: Obstructive sleep apnea (OSA) is described as a disturbance of sleep presentingrepetitive (either total or partial) closure of the upper airway. Studies have demonstrated that OSA inthe middle-aged induces excessive daytime sleepiness; mood problems and poor quality of life. OSAis characterized by repetitive narrowing or obstruction of the upper airway during sleep, resultingin apnea or hypopnea. Patients with OSA have shown poor sleep quality. Purpose: To evaluate thepossible association between OSA and patients’ sleep quality. Literature review: OSA is a commonsleep disturbance classified by intermittent partial or total upper airway obstruction during sleep, causing intermittent hypoxemia, recurrent arousals, sleep fragmentation, and poor sleep quality. OSA is related to the quality of life, depression, and anxiety, but there were associations with acute stress which were reported by a few studies. Most of studies on OSA had collected data from moderate to severe sleep apnea in elderly patients and clinical settings. Continuous positive airway pressure (CPAP) therapy, which provides a mechanical pneumatic stent for the upper airway, is an effective treatment for OSA. As a rule, it is given via a nasal mask, and therefore patients should ideally keep their mouth closed during sleep. Conclusion: The literature review showed that there was a significant association between obstructive sleep apnea risk and sleep quality. The risk of increasing OSA among young people is associated with acute stress, and the relationship is mediated by sleep quality.Keywords: sleep apnea, continuous positive airway pressure, upper airway obstruction
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Trosch, Richard M., Cynthia L. Comella, Stanley N. Caroff, William G. Ondo, Alicia C. Shillington, Brandon J. LaChappelle, Robert A. Hauser, Christof U. Correll, and Joseph H. Friedman. "Reliability of the Clinician’s Tardive Inventory (CTI)." CNS Spectrums 28, no. 2 (April 2023): 219. http://dx.doi.org/10.1017/s1092852923001347.

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AbstractObjectivesCurrently utilized clinician-rated symptom scales for tardive dyskinesia (TD) have not kept up with the expanding spectrum of TD phenomenology. The objective of this study was to develop and test the reliability of a new instrument, the CTI.MethodsA movement disorder neurologist devised the outline of the scale. A steering committee (four neurologists and two psychiatrists) provided revisions until consensus was reached. The resulting instrument assesses frequency of abnormal movements of the eye/eyelid/face, tongue/mouth, jaw, limb/trunk, complex movements (e.g., handwringing, self-caressing), and vocalizations. The CTI rates symptoms from 0–3 with 0 = absent, 1 = infrequent/intermittent or only present with activating maneuvers, 2 = frequent intermittent, brief periods without movements, 3 = constant or nearly constant. Functional impairments including activities of daily living (ADL), social impairment, symptom bother, and harm are rated 0–3 with 0 = patient is unaware or unaffected, 1 = symptoms mildly impact patient, 2 = symptoms moderately impact patient, 3 = symptoms severely impact patient. Following institutional review board approval, the CTI underwent inter-rater and test-retest reliability testing. Videos of patient TD examinations were obtained and reviewed by two movement disorder specialists to confirm the diagnosis of TD by consensus and the adequacy to demonstrate a TD-consistent movement. Vignettes were created to include patients’ symptom descriptions and functional, social, or occupational impairments/limitations. Four clinicians rated each video/vignette. Selected videos/vignettes were also subject to an intra-rater retest. Interrater agreement was analyzed via 2-way random-effects interclass correlation (ICC) and test-retest agreement assessment utilizing Kendall’s tau-b.Results45 video/vignettes were assessed for interrater reliability, and 16 for test-retest reliability. ICCs for movement frequency were as follows: abnormal eye movement .89; abnormal tongue/mouth movement .91; abnormal jaw movement .89; abnormal limb movement .76; complex movement .87; abnormal vocalization .77; and functional impairments including harm .82; social embarrassment .88; ADLs .83; and symptom bother .92. Retests were conducted on mean (SD) 15 (3) days later with scores ranging from .66–.87.ConclusionsThe CTI is a new instrument with good reliability in assessing TD symptoms and functional impacts. Future validation study is warranted.FundingNeurocrine Biosciences
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Fries, Matthew R., Rene L. Galindo, Paul W. Flint, and Susan C. Abraham. "Giant Fibrovascular Polyp of the Esophagus." Archives of Pathology & Laboratory Medicine 127, no. 4 (April 1, 2003): 485–87. http://dx.doi.org/10.5858/2003-127-0485-gfpote.

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Abstract Giant fibrovascular polyp of the esophagus is a rare but dramatic entity. These large polyps arise in the proximal esophagus and can cause airway obstruction secondary to mechanical pressure on the larynx, or they can present as a mass that is regurgitated into the oral cavity. We present a 66-year-old man who complained of nausea and vomiting that were associated with a fibrovascular polyp protruding into the mouth. He had also experienced several episodes of syncope resulting from intermittent airway obstruction. He underwent an open resection of an 11.8-cm fibrovascular polyp and an endoscopic resection of a second fibrovascular polyp 2 days later. Histopathologically, both masses were composed of a mixture of mature adipose tissue lobules and fibrovascular tissue, lined by reactive squamous epithelium. Despite their large size, giant fibrovascular polyps should be recognized radiologically and pathologically as benign lesions. However, they can result in significant morbidity.
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Sánchez Terán, Alfonso Iván, Anyely Nataly Fuertes-Muñoz, Martha Elena Gutiérrez-Brambila, Juan Carlos Luna-García, Luis Anibal Cervantes-Ruíz, Luis Abraham Zúñiga-Vázquez, and Gerardo Chávez-Pérez. "Radial Forearm Free Flap for Tongue Reconstruction." International Journal of Innovative Research in Medical Science 8, no. 08 (August 1, 2023): 340–45. http://dx.doi.org/10.23958/ijirms/vol08-i08/1727.

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A woman in his mid-50s presented with an ulcer on the right side of her tongue associated with sore throat. The lesion progressively grew until it became exophytic. An incisional biopsy showed a well-differentiated squamous cell carcinoma, invasive, ulcerated, p16 positive, with lymphovascular permeation and muscle infiltration so she was referred to a surgical oncologist. There was history of oral sex habits and poor dental hygiene. At physical examination there was a 2.5 x 2 cm neoformation on the right lateral side of the tongue associated with pain, which was mild, intermittent, and localized, the base of the tongue and floor of the mouth were apparently free. The team decided to perform a right hemiglossectomy plus radical neck dissection. Given the anatomical and functional needs of the area, a microvascular reconstruction with a Radial Forearm Free Flap was chosen due to its thinness, flexibility, ease of harvest, and reliability.
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Chong, S. K. F., V. M. Wright, T. Nishigame, F. Raafat, D. Isaacs, B. C. Morson, and J. A. Walker‐Smith. "Infantile Colitis." Journal of Pediatric Gastroenterology and Nutrition 7, no. 4 (July 1988): 622–27. http://dx.doi.org/10.1002/j.1536-4801.1988.tb09601.x.

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Summary:A brother and sister of first cousin Pakistani parents presented with recurrent mouth ulcers and chronic diarrhoea in the neonatal period. Diarrhoea persisted in spite of treatment with oral prednisolone and sulphasalazine. Both children required subtotal colectomy with ileostomy. Histopathology of the resected colons was virtually identical and showed multiple deep “flask”‐shaped ulcers, often penetrating to the serosa, in the presence of chronic inflammation, but without any of the characteristic histological features of Crohn's disease. The appearance closely resembled the colitis of Behcet's syndrome. Both children (aged 6 and 3.5 years, respectively) have continued to have recurrent perianal disease with intermittent bloody diarrhoea since the operation. Apart from the initial symptoms of oral aphthous ulcerations in both children, no other major criteria have developed so far. Intestinal Behcet's syndrome should be considered in the differential diagnosis of chronic inflammatory bowel disease in childhood.
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Go, Jamie Olivia C., Olivia C. Go, and Clara R. Rivera. "The Association of Sleep-Related Breathing Disorders Among Pediatric Patients with Allergic Rhinitis: A Cross-Sectional Study in a University Hospital." Journal of Medicine, University of Santo Tomas 5, no. 2 (December 31, 2021): 783–90. http://dx.doi.org/10.35460/2546-1621.2020-0017.

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Introduction: Allergic rhinitis is a common condition in children linked to sleep-related breathing disorders (SRBD). Because of nasal congestion, it can cause obstructive sleep apnea, sleep fragmentation, and excessive fatigue. Studies regarding its association with SRBD is limited. Objectives: To determine the association of allergic rhinitis with sleep-related breathing disorders. Methodology: A cross-sectional analytical study involving pediatric patients diagnosed with allergic rhinitis was conducted. Allergic rhinitis severity was evaluated with the ARIA classification. SRBD was identified using the validated Filipino version of the pediatric sleep questionnaire. Potential association between allergic rhinitis and SRBD were assessed using the student’s t-test, Fisher’s exact test and odds ratio. Results: A total of 66 children with mean age 8.2 years were included in the study. The mean age, weight, height, and BMI were comparable among participants who were positive or negative for obstructive sleep apnea (OSA). Among the perceived problems related to sleeping disorders, snoring loudly, heavy breathing, dry mouth of awakening, not listening, and difficulty organizing showed different responses (p<0.05) among the subgroups of allergic rhinitis. The odds ratio of snoring loudly, not listening, difficulty organizing, heavy breathing, and unfreshened in the morning were more likely among patients with mild persistent allergic rhinitis compared to patients with mild intermittent allergic rhinitis. Conclusion: There was sufficient evidence to prove the association of SRBD with severity of allergic rhinitis using the validated Filipino version of the Pediatric Sleep Questionnaire. OSA shows a greater likelihood among patients with mild persistent allergic rhinitis compared to those with mild intermittent allergic rhinitis.
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Puddy, A., W. Patrick, K. Webster, and M. Younes. "Respiratory control during volume-cycled ventilation in normal humans." Journal of Applied Physiology 80, no. 5 (May 1, 1996): 1749–58. http://dx.doi.org/10.1152/jappl.1996.80.5.1749.

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The purpose of this study was to evaluate the extent of inhibition to respiratory rhythm associated with high volumes of ventilation during volume-cycled mechanical ventilation (neuromechanical inhibition). Two approaches were used. 1) In 18 normal awake subjects, ventilator tidal volume (VT) in the assist/control mode (A/C) was increased in steps from the minimum tolerable level up to 80% of the subject's inspiratory capacity or ventilator's maximum VT. We looked for appearance of intermittent apnea or a reduction in spontaneous rate (f). 2) Another 18 normal awake subjects were placed on controlled mechanical ventilation (CMV). When apnea was established, we abruptly terminated CMV and measured the time before the appearance of the next spontaneous effort. In the assist mode (protocol 1), we did not observe intermittent apnea because VT was increased from [from 944 +/- 198 to 1,867 +/- 277 (SD) ml], and there was only a modest reduction in f (14.1 +/- 3.9 to 12.4 +/- 4.0 breaths/min). End-tidal PCO2 (PETCO2) decreased precipitously as VT was increased. In protocol 2, we did not observe apnea after discontinuation of CMV in any subject. Total breath duration of the first breath after discontinuation did not differ significantly from total breath duration during A/C in the same subjects (4.84 +/- 2.2 vs. 5.2 +/- 2.0 s). This similarly applied regardless of route of breathing (nose vs. mouth) or PETCO2 level at time of discontinuation. We conclude that neuromechanical inhibition is quite weak and provides very little negative feedback that may help control PCO2 in the face of excessive VT and f demands of the subject.
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Kim, Dong Hyun, Hee Kyung Yang, Sang Beom Han, and Jeong-Min Hwang. "Effect of Topical Brimonidine 0.15% on Conjunctival Injection after Strabismus Surgery in Children." Journal of Ophthalmology 2021 (May 4, 2021): 1–5. http://dx.doi.org/10.1155/2021/5574194.

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Purpose. To investigate the effects of topical brimonidine 0.15% instillation on conjunctival injection after strabismus surgery in children. Methods. We retrospectively analyzed 63 Korean children who underwent strabismus surgery for intermittent exotropia. Patients received topical brimonidine 0.15% after surgery for up to 4 weeks. Conjunctival injection was objectively assessed using a software that automatically scored the region of interest from the image of the bulbar conjunctiva. Conjunctival injection scores were compared with those of the control group who were not prescribed topical brimonidine. Results. The mean scores of conjunctival injection after rectus muscle recession and resection were significantly lower in the brimonidine group than the controls at 4 weeks after surgery ( P = 0.008 and 0.046 , respectively). There was no significant difference in intraocular pressure between the two groups. No adverse effects, such as dry mouth, fatigue/drowsiness, headache, sedation, hypotension, or bradycardia, were reported. Conclusions. Administration of topical brimonidine 0.15% after strabismus surgery is efficacious and safe in reducing postoperative conjunctival injection.
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Majid, Aisha, Qurat Ul Ain Sameed, Saima Asim, Nauman Shirazi, Syed Muhammad Abdullah Salman, Syeda Munazza Gillani, and Sajid Ali. "Antibacterial efficacy of aloevera peel extract against streptococcus mutans and P. gingivalis." International journal of health sciences 7, S1 (June 27, 2023): 2035–43. http://dx.doi.org/10.53730/ijhs.v7ns1.14450.

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Background: The anti-inflammatory, antioxidant, antiviral, antibacterial, antitumor, antiarthritic, and anti-diabetic properties of aloe vera has been well documented in the literature. Considering its antibacterial properties evaluating its benefits as mouth rinse in the oral diseases may facilitate the patients in getting cheaper and safer herbal remedy to clean their oral cavities. Objective: To evaluate the Antibacterial efficacy of aloevera peel extract against Streptococcus mutans and P. gingivalis. Methodology: It was a preclinical experimental study conducted at Baqai Medical and Dental College Karachi, from February to March 2023. Calculated sample size was n =60. The participants were given an envelope for group randomization. S. mutant samples and P. gingivalis were incubated on appropriate media. The Aloe Vera leaves were washed and gel was removed the peels were shed dried and lastly was grinded to powder form. Ethanol (70%) were used for soaking for 15 days with intermittent shaking. The extract was diluted in distilled water in 1:4 (Extract: Distilled water) concentration.
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Rizvi, Omar, Tyson Nielsen, and Shethal Bearelly. "Mucosa-Associated Lymphoid Tissue Lymphoma of the Larynx." Case Reports in Otolaryngology 2020 (August 18, 2020): 1–4. http://dx.doi.org/10.1155/2020/8703921.

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Background. Mucosa-associated lymphoid tissue (MALT) lymphomas are a subtype of non-Hodgkin lymphoma stemming from marginal zone B-cells. In this case report, we present two patients with an extremely rare localization of MALT lymphoma to the larynx. Methods. Case 1 is of a 78-year-old male presenting with a six-month history of progressive hoarseness with a past medical history significant for marginal zone lymphoma of the right orbit. Diagnosis was confirmed with a biopsy for extranodal marginal zone B-cell lymphoma of MALT type. An FDG-PET scan was done but did not show any sign of FDG avid malignancy, including at the primary site. Case 2 is a 60-year-old female presenting with one year of worsening throat discomfort, intermittent cough, and dyspnea with exertion. Pathology confirmed a diagnosis of extranodal marginal zone B-cell lymphoma of MALT type. Results. Case 1 was treated with low-dose radiation at 4 Gy delivered over two fractions of 2 Gy each. Upon completion of radiation treatment, he reported a resolution of his hoarseness and normalization of his voice. A four-month follow-up in May 2018 with flexible nasolaryngoscopy revealed a normal exam with fully mobile vocal folds bilaterally and no evidence of left false vocal fold submucosal mass. At seven months following treatment, the patient died unexpectedly of unknown causes. Case 2 was treated with radiation at 30 Gy in 15 fractions over the course of one month. Following completion of radiation therapy, she had improvement of her sore throat, nausea, dysphagia, dysgeusia, and dry mouth. At 21-month follow-up, she had no evidence of disease. Conclusion. This case report demonstrates that MALT lymphoma can present with much more benign and subtle symptoms. This highlights the importance of clinicians to keep broad differentials and consider MALT lymphomas in the setting of laryngeal masses.
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Tong, Xin, and Bao-Zhen Hua. "Nuptial feeding and genital coupling of Neopanorpa scorpionflies (Insecta: Mecoptera: Panorpidae) with notal organs of various lengths." Contributions to Zoology 88, no. 4 (October 3, 2019): 498–512. http://dx.doi.org/10.1163/18759866-20191409.

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Neopanorpa, the second largest genus in Panorpidae, is mainly characterized by the well-developed notal organ on male tergum III. However, it remains largely unknown how the length of the notal organ influences the nuptial feeding behaviour of Neopanorpa. Here, we investigated the nuptial feeding by comparing the morphology of mating-related structures and the genital coupling of a) Neopanorpa lui Chou & Ran, 1981 with a weakly-developed notal organ, b) N. carpenteri Cheng, 1957 with a medium-sized notal organ, and c) N. longiprocessa Hua & Chou, 1997 with an extremely elongated notal organ. The couples of N. lui and N. carpenteri maintain an intermittent mouth-to-mouth mode but do not exchange any edible food. After that the males secrete a salivary mass onto the surface as a nuptial gift, which is distinctly larger in N. carpenteri than in N. lui. Correspondingly, the male salivary glands are more developed in N. carpenteri than in N. lui. Males of N. longiprocessa bear very short salivary glands corresponding to a coercive mating tactic. The genital couplings are similar among the three species of Neopanorpa. The paired hypovalves of males are used to control the cerci of females. The prominent basal processes of male gonostyli grasp the posterior portion of the female medigynium across the intersegmental membrane. The male aedeagus physically couples with the female medigynium to ensure the male phallotreme to connect to the female copulatory pore. The influence of the notal organ length on the nuptial feeding behaviour of Neopanorpa is briefly discussed.

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