Relevant bibliographies by topics / Intermediolateral cell column of spinal cord

Academic literature on the topic 'Intermediolateral cell column of spinal cord'

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Published: 4 June 2021
Last updated: 2 February 2022

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Journal articles on the topic "Intermediolateral cell column of spinal cord"

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Kirby, Michael A., Mary M. Groves, and Steven M. Yellon. "Retrograde tracing of spinal cord connections to the cervix with pregnancy in mice." REPRODUCTION 139, no. 3 (March 2010): 645–53. http://dx.doi.org/10.1530/rep-09-0361.

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In contrast to the uterus, the cervix is well innervated during pregnancy and the density of nerve fibers increases before birth. To assess neural connections between the cervix and the spinal cord, the cervix of pregnant mice was injected with the trans-synaptic retrograde neural tract tracer pseudorabies virus (PRV). After 5 days, the virus was present in nerve cells and fibers in specific areas of the sensory, autonomic, and motor subdivisions of the thoracolumbar spinal cord. In nonpregnant controls, the virus was predominantly distributed in laminae I–III in the dorsal gray sensory areas with the heaviest label in the substantia gelatinosa compared with the autonomic or motor areas. Labeled cells and processes were sparse in other regions, except for a prominent cluster in the intermediolateral column (lamina VII). Photomicrographs of spinal cord sections were digitized, and the total area with the virus was estimated. Compared with nonpregnant controls, the area with PRV was significantly decreased in all the spinal cord subdivisions in pregnant mice except in the intermediolateral column. However, areas with the virus were equivalent in mice injected with PRV at 4 days or 1 day before birth. These findings suggest that the predominant innervation of the murine cervix is from the sensory regions of the thoracolumbar spinal cord, and that these connections diminish with pregnancy. The results raise the possibility that the remaining connections from sensory and autonomic subdivisions, particularly the intermediolateral column, of the thoracolumbar spinal cord may be important for increased density of nerve fibers in the cervix as pregnancy nears term.
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Xu, Zemin, Ping Li, Chuanyao Tong, Jorge Figueroa, Joseph R. Tobin, and James C. Eisenach. "Location and Characteristics of Nitric Oxide Synthase in Sheep Spinal Cord and Its Interaction with α2-Adrenergic and Cholinergic Antinociception." Anesthesiology 84, no. 4 (April 1, 1996): 890–99. http://dx.doi.org/10.1097/00000542-199604000-00017.

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Background Nitric oxide synthase is located in the spinal cord dorsal horn and intermediolateral cell column, where it may modulate sensory and sympathetic neuronal activity. However, the biochemical characteristics of this enzyme have not been examined in these different areas in the spinal cord. Although alpha(2)-adrenergic agonists, muscarinic agonists, and nitric oxide may interact in the spinal cord to produce antinociception, these interactions have not been characterized. Methods Sheep spinal cord tissue was homogenized ad centrifuged at high sped to separate soluble and membrane-bound fractions. Nitric oxide synthase activity was determined by conversion of [(14)C]-L-arginine to [(14)C]-L-citrulline and its kinetic characteristics, dependency on cofactors, and sensitivity to inhibitors determined. Sheep spinal cord was stained for nicotinamide adenine dinucleotide phosphate diaphorase as a marker for nitric oxide synthase. Antinociception to a mechanical stimulus from intrathecal clonidine alone and with neostigmine was determined and the effects of L-arginine and n-methyl-L-arginine were determined. Results More than 85% of nitric oxide synthase activity was present in the soluble form and its kinetic, cofactor, and antagonist properties were similar to those of the neuronal isoform of nitric oxide synthase. Biochemical and histochemical studies localized nitric oxide synthase to the superficial dorsal horn and the intermediolateral cell column. Clonidine antinociception was enhanced by L-arginine and neostigmine, but not by D-arginine. Neostigmine's enhancement of clonidine antinociception was blocked by n-methyl-L-arginine. Conclusions These results confirm those of previous studies demonstrating localization of nitric oxide synthase to superficial dorsal horn and intermediolateral cell column of mammalian spinal cord, and suggesting its identity as the neuronal isoform. Spinal alpha(2)-adrenergic agonist antinociception may be partly dependent on cholinergic and nitric oxide mechanisms.
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McCartney, Annemarie M., Vanessa L. Abejuela, and Lori G. Isaacson. "Characterization of trkB immunoreactive cells in the intermediolateral cell column of the rat spinal cord." Neuroscience Letters 440, no. 2 (August 2008): 103–8. http://dx.doi.org/10.1016/j.neulet.2008.05.057.

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Llewellyn-Smith, I. J., J. B. Minson, D. A. Morilak, J. R. Oliver, and J. P. Chalmers. "Neuropeptide Y-immunoreactive synapses in the intermediolateral cell column of rat and rabbit thoracic spinal cord." Neuroscience Letters 108, no. 3 (January 1990): 243–48. http://dx.doi.org/10.1016/0304-3940(90)90648-s.

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Iigaya, Kamon, Hiroo Kumagai, Hiroshi Onimaru, Akira Kawai, Naoki Oshima, Toshiko Onami, Chie Takimoto, et al. "Novel axonal projection from the caudal end of the ventrolateral medulla to the intermediolateral cell column." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 292, no. 2 (February 2007): R927—R936. http://dx.doi.org/10.1152/ajpregu.00254.2006.

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We used an optical imaging technique to investigate whether axons of neurons in the caudal end of the ventrolateral medulla (CeVLM), as well as axons of neurons in the rostral ventrolateral medulla (RVLM), project to neurons in the intermediolateral cell column (IML) of the spinal cord. Brain stem-spinal cord preparations from neonatal normotensive Wistar-Kyoto and spontaneously hypertensive rats were stained with a voltage-sensitive dye, and responses to electrical stimulation of the IML at the Th2 level were detected as changes in fluorescence intensity with an optical imaging apparatus (MiCAM-01). The results were as follows: 1) depolarizing responses to IML stimulation during low-Ca high-Mg superfusion were detected on the ventral surface of the medulla at the level of the CeVLM, as well as at the level of the RVLM, 2) depolarizing responses were also detected on cross sections at the level of the CeVLM, and they had a latency of 24.0 ± 5.5 (SD) ms, 3) antidromic action potentials in response to IML stimulation were demonstrated in the CeVLM neurons where optical images were detected, and 4) glutamate application to the CeVLM increased the frequency of excitatory postsynaptic potentials (EPSPs) and induced depolarization of the IML neurons. The optical imaging findings suggested a novel axonal and functional projection from neurons in the CeVLM to the IML. The increase in EPSPs of the IML neurons in response to glutamate application suggests that the CeVLM participates in the regulation of sympathetic nerve activity and blood pressure and may correspond to the caudal pressor area.
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Jansen, A. S. P., and A. D. Loewy. "Neurons lying in the white matter of the upper cervical spinal cord project to the intermediolateral cell column." Neuroscience 77, no. 3 (February 1997): 889–98. http://dx.doi.org/10.1016/s0306-4522(96)00506-4.

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Ding, XiaoHui, Jeffrey L. Ardell, Fang Hua, Ryan J. McAuley, Kristopher Sutherly, Jala J. Daniel, and Carole A. Williams. "Modulation of cardiac ischemia-sensitive afferent neuron signaling by preemptive C2 spinal cord stimulation: effect on substance P release from rat spinal cord." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 294, no. 1 (January 2008): R93—R101. http://dx.doi.org/10.1152/ajpregu.00544.2007.

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The upper cervical spinal region functions as an intraspinal controller of thoracic spinal reflexes and contributes to neuronal regulation of the ischemic myocardium. Our objective was to determine whether stimulation of the C2 cervical spinal cord (SCS) of rats modified the input signal at the thoracic spinal cord when cardiac ischemia-sensitive (sympathetic) afferents were activated by transient occlusion of the left anterior descending coronary artery (CoAO). Changes in c-Fos expression were used as an index of neuronal activation within the spinal cord and brain stem. The pattern of substance P (SP) release, a putative nociceptive transmitter, was measured using antibody-coated microprobes. Two SCS protocols were used: reactive SCS, applied concurrently with intermittent CoAO and preemptive, sustained SCS starting 15 min before and continuing during the repeated intermittent CoAO. CoAO increased SP release from laminae I and II in the T4 spinal cord above resting levels. Intermittent SCS with CoAO resulted in greater levels of SP release from deeper laminae IV–VII in T4 than CoAO alone. In contrast, SP release from laminae I and II was inhibited when CoAO was applied during preemptive, sustained SCS. Preemptive SCS likewise reduced c-Fos expression in the T4 spinal cord (laminae I–V) and nucleus tractus solitarius but increased expression in the intermediolateral cell column of T4 compared with CoAO alone. These results suggest that preemptive SCS from the high cervical region modulates sensory afferent signaling from the ischemic myocardium.
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Llewellyn-Smith, Ida J., Jane B. Minson, Paul M. Pilowsky, and John P. Chalmers. "THERE ARE FEW CATECHOLAMINE- OR NEUROPEPTIDE Y-CONTAINING SYNAPSES IN THE INTERMEDIOLATERAL CELL COLUMN OF RAT THORACIC SPINAL CORD." Clinical and Experimental Pharmacology and Physiology 18, no. 2 (February 1991): 111–15. http://dx.doi.org/10.1111/j.1440-1681.1991.tb01418.x.

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Sundaram, Kalyana, Jaya Murugaian, and Hreday Sapru. "Cardiac responses to the microinjections of excitatory amino acids into the intermediolateral cell column of the rat spinal cord." Brain Research 482, no. 1 (March 1989): 12–22. http://dx.doi.org/10.1016/0006-8993(89)90537-4.

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Rosas-Arellano, M. Patricia, L. Pastor Solano-Flores, and John Ciriello. "c-Fos induction in spinal cord neurons after renal arterial or venous occlusion." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276, no. 1 (January 1, 1999): R120—R127. http://dx.doi.org/10.1152/ajpregu.1999.276.1.r120.

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Experiments were done in the anesthetized rat to identify the dorsal root ganglia (DRG) and the spinal cord segments that contain neurons activated by either renal venous occlusion (RVO) or by renal arterial occlusion (RAO). Fos induction, detected immunohistochemically in DRG and the spinal cord neurons, was used as a marker for neuronal activation. RVO induced Fos immunoreactivity in neurons in the DRG of spinal segments T8-L2on the side ipsilateral to that of occlusion. The largest number of Fos-labeled neurons was found in the T11 DRG. In the spinal cord the largest number of Fos-labeled neurons was found in the ipsilateral dorsal horn of spinal segments T11-T12, predominantly in a cluster near the dorsomedial edge of laminae I-II. A few additional Fos-labeled neurons were observed in laminae IV and V. After RAO Fos-labeled neurons were found in the ipsilateral DRG of spinal segments similar to those observed to contain neurons after RVO. However, most of the Fos-labeled neurons were observed within the T12-L1DRG. In the spinal cord Fos-labeled neurons were scattered throughout lamina I-II of the ipsilateral dorsal horn of spinal segments T8-L2, although the largest number was observed at the T13 level. Additionally, a distinct cluster of Fos-labeled neurons was observed predominantly in the region of the ipsilateral intermediolateral cell column, although a few neurons were found scattered throughout the nucleus intercalatus, central autonomic areas, and laminae IV and V of the cord bilaterally. No Fos labeling was observed in the complementary contralateral DRG or dorsal horns after either RVO or RAO. In addition, renal nerve transection prevented Fos labeling in the ipsilateral DRG and dorsal horns after RVO or RAO. Taken together, these data suggest that functionally different renal afferent fibers activate DRG neurons that may have distinct projections in the spinal cord.
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Dissertations / Theses on the topic "Intermediolateral cell column of spinal cord"

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Gannon, Sean Michael. "Plasticity in the intermediolateral cell column of the spinal cord following injury to sympathetic postganglionic axons." Miami University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1407112137.

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Cham, Joo Lee, and julie cham@rmit edu au. "The role of the hypothalamic paraventricular nucleus in the cardiovascular responses to elevations in body temperature." RMIT University. Medical Sciences, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080805.114529.

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The hypothalamic paraventricular nucleus (PVN) is known to be a major integrative region within the forebrain. It is composed of functionally different subgroups of neurons, including the parvocellular neurons that project to important autonomic targets in the brainstem e.g. the rostral ventrolateral medulla (RVLM) and the intermediolateral cell column (IML) of the spinal cord, where the sympathetic preganglionic motor-neurons are located. These regions are critical in cardiovascular regulation; hence, these projections are likely to mediate the effects of the PVN on sympathetic nerve activity and hence may contribute to the cardiovascular changes induced by physiological stimuli such as elevations in body temperature. The neurotransmitter such as nitric oxide (NO) is important in cardiovascular regulation and it is now emerging as a major focus of investigation in thermoregulation. One of the most striking accumulations of NO containing-neurons is in the PVN where it appears to be playing an important role in cardiovascular regulation and body fluid homeostasis. The results of the work show; 1. That spinally-projecting and nitrergic neurons in the PVN may contribute to the central pathways activated by exposure to a hot environment. 2. Suggests that nitrergic neurons and spinally- projecting neurons in the brainstem may make a small contribution to the central pathways mediating the reflex responses initiated by hyperthermia. 3. The present study also illustrates that these PVN neurons projecting to the RVLM may make a smaller contribution than the spinal-projecting neurons in the PVN to the cardiovascular responses initiated by heat. 4. The results of my studies showed that the microinjection of muscimol to inhibit the neuronal activity in the PVN abolished the reflex decrease in renal blood flow following an elevation of core body temperature. In addition, this effect was specific to the PVN, since microinjections of muscimol into areas outside the PVN were not effective. These findings demonstrate that the PVN is critical for this reflex cardiovascular response initiated by hyperthermia. In conclusion, PVN is critical for the reflex decrease in renal blood flow during elevations in core body temperature. We hypothesise that projections from the PVN to the spinal cord and the RVLM contribute to the reflex cardiovascular responses. Additionally, nitrergic neurons in the PVN may contribute but the physiological role of those neurons in the reflex responses elicited by hyperthermia needs to be investigated.
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Coulibaly, Aminata P. "Changes in Sympathetic Preganglionic Neurons and Associated Glial Cells following Injury." Miami University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=miami1281032308.

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EN-YUAN, PAN, and 潘恩源. "Contribution of Glutamate Receptors in Intermediolateral Cell Column of Thoracic Spinal Cord to Sympathetic Vasomotor Tone Under Physiological Conditions and During Experimental Endotoxemia." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/42873783919293325733.

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博士
長庚大學
臨床醫學研究所
94
The management of septic patients posts a professional challenge because of the reduction in systemic vascular resistance and the progressively diminished response to sympathomimetic pressor agents. The refractory hypotension remains a significant cause of morbidity and mortality in septic patients. Under physiological conditions, neurogenic vasomotor tone plays an important role in the maintenance of normal blood pressure. A better understanding of the regulatory machinery on neurogenic vasomotor tone during sepsis is therefore of vital importance. The integrity of rostral ventrolateral medulla (RVLM), bulbospinal tract, and intermediolateral cell column (IML) plays an important role in maintaining resting vasomotor tone. The vasomotor components of the systemic arterial pressure (SAP) spectrum reflect the activities of the sympathetic premotor neurons in RVLM, and the vasomotor signals are transmitted through activation of glutamate receptors on sympathetic preganglionic neurons (SPN) in IML. However, the relative contribution of the two major subtypes of glutamate receptors, NMDA and non-NMDA receptors, to the generation of neurogenic vasomotor tone under physiological conditions or during experimental endotoxemia is basically unknown. We addressed this issue by using a combination of physiological, pharmacological and double immunofluorescence approaches to delineate the relative contribution of NMDA and non-NMDA receptors on SPN to the generation of neurogenic vasomotor tone under physiological conditions and during experimental endotoxemia. For more accurate distribution of drugs over the specific IML region, a pre-implanted catheter in the thoracic subarachnoid space is mandatory. The currently available methods for catheterization of the thoracic spinal subarachnoid space in rats have been associated with relatively high postoperative mortality and morbidity. In our study, we developed a better method of catheterization. An intrathecal catheter was fabricated with a small silicon bead at one end of a PE-10 catheter, which was cannulated with a 4/0 suture that served as a guide. Using the L-shape hook of the suture guide as an anchorage, the catheter was advanced into the subarachnoid space until the silicon bead was lodged on a drilled hole (2 x 2 mm) over the lamina proper on the T13 vertebrae. The applicability of the implanted catheter was demonstrated by myelogram and pharmacological studies. Adult male Sprague-Dawley rats maintained under propofol anesthesia were used. Intrathecal administration of equimolar concentrations (75, 150 or 300 nmol) of a NMDA antagonist, dizocilpine (MK801) or a non-NMDA antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) into T10-T12 spinal cord elicited a reduction in resting vasomotor tone that was comparable in time-course and in magnitude. At the same time, both glutamate receptor antagonists exacerbated mortality and potentiated the elicited hypotension, bradycardia or reduction in vasomotor tone during experimental endotoxemia induced by intravenous administration of Escherichia coli lipopolysaccharide (30 mg/kg). Results comparable to CNQX at 150 nmol were obtained only when MK801 was given at 300 nmol. Confocal microscopy further showed that augmented immunoreactivity of NR1 subunit of the NMDA receptor on IML neurons coincided with the phase of endotoxemia when vasomotor tone was augmented; the immunoreactivity GluR1 subunit of the non-NMDA receptor remained stable throughout experimental endotoxemia. Correct localization and identification of SPN was crucial to the interpretation of our results. We thus have to be familiar with the location, morphology, and distribution of SPN in IML for accurate location of glutamate receptor expression on SPN. c-fos protein was induced in SPN through electrical stimulation to RVLM and visualized by immunohistochemical method. It was found that c-fos positive cells were not present in the spinal cord except within the IML region. We concluded that NMDA and non-NMDA receptors on IML neurons contribute equally to the generation of resting sympathetic vasomotor tone. However, upregulation of NMDA receptors on IML neurons plays a crucial role in the maintenance of vasomotor tone during endotoxemia.
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Book chapters on the topic "Intermediolateral cell column of spinal cord"

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Chiba, T., and S. Masuko. "Synaptic Organization of the Intermediolateral Nucleus of the Thoracic Spinal Cord: Monoamine Histochemistry and Peptide Immunohistochemistry." In Histochemistry and Cell Biology of Autonomic Neurons and Paraganglia, 157–62. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72749-8_28.

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McCarty, Richard. "Stress-Sensitive Brain Circuits." In Stress and Mental Disorders: Insights from Animal Models, 121–66. Oxford University Press, 2020. http://dx.doi.org/10.1093/med-psych/9780190697266.003.0005.

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A series of forebrain, midbrain, and brainstem nuclei exert stimulatory or inhibitory effects on sympathetic outflow from the intermediolateral cell column in thoracic and lumbar areas of the spinal cord. Some of these brain areas contain cell bodies that serve as command neurons that can simultaneously activate sympathetic outflow to multiple target tissues. CRF-containing cell bodies in the paraventricular nuclei receive multiple direct and indirect inputs from various brain areas that participate in the regulation of the HPA axis. Hormones of the adrenal cortex have been shown to exert damaging structural effects on the structure of neurons in the hippocampus and amygdala. The immune system is stress-responsive, and circulating immune cells and proinflammatory cytokines are able to penetrate the blood-brain barrier during exposure to stressors. Brain microglia appear to serve as neuroimmune sensors of stress. Optogenetic and chemogenetic techniques have been essential tools in probing the functions of stress-responsive brain circuits and their impact on behavior.
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Atkinson, Martin E. "The autonomic nervous system." In Anatomy for Dental Students. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199234462.003.0025.

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A large part of the nervous system is dedicated to the control of the internal viscera and their functions. Much of the activity of these organs is controlled reflexly at the brainstem level, e.g. the cardiovascular and respiratory centres (the vital centres) in the reticular formation of the medulla controlling cardiac and respiratory activity. There are also centres in the cerebrum, notably the hypothalamus in the diencephalon. Somatic and visceral functions are closely integrated at these higher levels; think of the effect that emotional factors or somatic stimulation can have on heart rate, blood pressure, and gastrointestinal activity when we are nervous or are in pain. The nerves involved in these activities are described as visceral sensory or visceral motor nerves because they control visceral function; this distinguishes them from somatic sensory nerves from peripheral receptors and somatic motor nerves controlling voluntary function. Visceral motor neurons innervate smooth muscle and secretory cells of the gastrointestinal and respiratory systems, the smooth and cardiac muscle of the cardiovascular system, the sweat glands and arrector pili muscles of the skin, and the muscles of the ciliary body and iris of the eyeball. In many cases, there is a dual supply from the sympathetic and parasympathetic divisions of the autonomic nervous system. In both divisions of the autonomic nervous system, there is a sequence of two neurons between the CNS and the effector organ which synapse in peripheral autonomic ganglia. The neurons from the CNS to the synapse in the ganglion are the preganglionic neurons and those from the ganglia to the effector organs are the postganglionic neurons. The enteric plexus is a third set of neurons interposed between the post-ganglionic neurons and the effector cells in the gastrointestinal tract. Figure 17.1 compares the general arrangement of the sympathetic and parasympathetic nervous system. The cell bodies of sympathetic visceral preganglionic motor neurons are located in the intermediolateral horns of the thoracic and upper lumbar segments of the spinal cord while those of the parasympathetic visceral preganglionic (secretomotor) neurons are in the nuclei of four of the cranial nerves and the sacral segments of the spinal cord.
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